WO2006108586A3 - Polymyxin b analogs for lps detoxification - Google Patents
Polymyxin b analogs for lps detoxification Download PDFInfo
- Publication number
- WO2006108586A3 WO2006108586A3 PCT/EP2006/003237 EP2006003237W WO2006108586A3 WO 2006108586 A3 WO2006108586 A3 WO 2006108586A3 EP 2006003237 W EP2006003237 W EP 2006003237W WO 2006108586 A3 WO2006108586 A3 WO 2006108586A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lps
- dimers
- peptide
- saep
- leu
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0610701-0A BRPI0610701A2 (en) | 2005-04-11 | 2006-04-10 | saep ii peptide dimer, composition containing it, its use, lps-peptide complex, its use, pharmaceutical composition and process for its preparation, process for detoxifying one lps of gram-negative bacteria and process for the preparation of a parallel and antiparallel peptide dimer saep ii |
CA002603850A CA2603850A1 (en) | 2005-04-11 | 2006-04-10 | Polymyxin b analogs for lps detoxification |
AU2006233634A AU2006233634A1 (en) | 2005-04-11 | 2006-04-10 | Polymyxin B analogs for LPS detoxification |
MX2007012457A MX2007012457A (en) | 2005-04-11 | 2006-04-10 | Polymyxin b analogs for lps detoxification. |
JP2008505786A JP2008537749A (en) | 2005-04-11 | 2006-04-10 | Polymyxin B analog for LPS detoxification |
NZ561374A NZ561374A (en) | 2005-04-11 | 2006-04-10 | Polymyxin B analogs for LPS detoxification |
EP06724173A EP1871787A2 (en) | 2005-04-11 | 2006-04-10 | Polymyxin b analogs for lps detoxification |
IL186322A IL186322A0 (en) | 2005-04-11 | 2007-09-25 | Polymyxin b analogs for lps detoxification |
NO20075753A NO20075753L (en) | 2005-04-11 | 2007-11-09 | Polymyxin B analogs for LPS detoxification |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05300270.5 | 2005-04-11 | ||
EP05300270A EP1712559A1 (en) | 2005-04-11 | 2005-04-11 | Polymyxin B analogs for LPS detoxification |
EP05300319 | 2005-04-26 | ||
EP05300319.0 | 2005-04-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006108586A2 WO2006108586A2 (en) | 2006-10-19 |
WO2006108586A3 true WO2006108586A3 (en) | 2006-12-14 |
Family
ID=36968822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/003237 WO2006108586A2 (en) | 2005-04-11 | 2006-04-10 | Polymyxin b analogs for lps detoxification |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1871787A2 (en) |
JP (1) | JP2008537749A (en) |
KR (1) | KR20070118646A (en) |
AU (1) | AU2006233634A1 (en) |
BR (1) | BRPI0610701A2 (en) |
CA (1) | CA2603850A1 (en) |
IL (1) | IL186322A0 (en) |
MX (1) | MX2007012457A (en) |
NO (1) | NO20075753L (en) |
NZ (1) | NZ561374A (en) |
WO (1) | WO2006108586A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5275982B2 (en) | 2006-06-12 | 2013-08-28 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | vaccine |
EP2429658B1 (en) | 2009-05-14 | 2016-04-20 | Sanofi Pasteur | Method for adjuvating the lipopolysaccharide (LPS) of gram-negative bacteria |
EP2430151B1 (en) | 2009-05-14 | 2014-06-18 | Sanofi Pasteur | Meningococcal vaccine constituted of lipooligosaccharides from modified immunotype l6 neisseria meninigitidis |
TWI548746B (en) * | 2009-08-06 | 2016-09-11 | 英特威特國際股份有限公司 | A vaccine directed against porcine pleuropneumonia and a method to obtain such a vaccine |
AR113430A1 (en) * | 2017-12-22 | 2020-04-29 | Hanmi Pharm Ind Co Ltd | THERAPEUTIC ENZYMATIC FUSION PROTEIN THAT HAS A NEW STRUCTURE AND ITS USE |
WO2021187928A1 (en) * | 2020-03-20 | 2021-09-23 | 단디바이오사이언스 주식회사 | Composition and kit for removing lipopolysaccharide |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993014115A1 (en) * | 1992-01-16 | 1993-07-22 | Massimo Porro | Synthetic peptides for detoxification of bacterial endotoxins and treatment of septic shock |
WO2004052394A1 (en) * | 2002-12-06 | 2004-06-24 | Biosynth S.R.L. | Broad-spectrum lps based vaccines of unencapsulated strains of haemophilus influenzae and other pathogenic species of gram-negative bacteria |
-
2006
- 2006-04-10 BR BRPI0610701-0A patent/BRPI0610701A2/en not_active IP Right Cessation
- 2006-04-10 MX MX2007012457A patent/MX2007012457A/en not_active Application Discontinuation
- 2006-04-10 KR KR1020077023738A patent/KR20070118646A/en not_active Application Discontinuation
- 2006-04-10 CA CA002603850A patent/CA2603850A1/en not_active Abandoned
- 2006-04-10 AU AU2006233634A patent/AU2006233634A1/en not_active Abandoned
- 2006-04-10 JP JP2008505786A patent/JP2008537749A/en active Pending
- 2006-04-10 WO PCT/EP2006/003237 patent/WO2006108586A2/en not_active Application Discontinuation
- 2006-04-10 EP EP06724173A patent/EP1871787A2/en not_active Withdrawn
- 2006-04-10 NZ NZ561374A patent/NZ561374A/en not_active IP Right Cessation
-
2007
- 2007-09-25 IL IL186322A patent/IL186322A0/en unknown
- 2007-11-09 NO NO20075753A patent/NO20075753L/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993014115A1 (en) * | 1992-01-16 | 1993-07-22 | Massimo Porro | Synthetic peptides for detoxification of bacterial endotoxins and treatment of septic shock |
WO2004052394A1 (en) * | 2002-12-06 | 2004-06-24 | Biosynth S.R.L. | Broad-spectrum lps based vaccines of unencapsulated strains of haemophilus influenzae and other pathogenic species of gram-negative bacteria |
Non-Patent Citations (2)
Title |
---|
DEMITRI M T ET AL: "INHIBITION OF LPS-INDUCED SYSTEMIC AND LOCAL TNF PRODUCTION BY A SYNTHETIC ANTI-ENDOTOXIN PEPTIDE (SAEP-2)", JOURNAL OF ENDOTOXIN RESEARCH, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 3, no. 6, December 1996 (1996-12-01), pages 445 - 454, XP009001817, ISSN: 0968-0519 * |
RUSTICI A ET AL: "MOLECULAR MAPPING AND DETOXIFICATION OF THE LIPID A BINDING SITE BYSYNTHETIC PEPTIDES", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 259, no. 5093, 15 January 1993 (1993-01-15), pages 361 - 365, XP000608499, ISSN: 0036-8075 * |
Also Published As
Publication number | Publication date |
---|---|
KR20070118646A (en) | 2007-12-17 |
CA2603850A1 (en) | 2006-10-19 |
BRPI0610701A2 (en) | 2010-07-20 |
AU2006233634A1 (en) | 2006-10-19 |
WO2006108586A2 (en) | 2006-10-19 |
NO20075753L (en) | 2007-11-09 |
IL186322A0 (en) | 2008-01-20 |
MX2007012457A (en) | 2007-12-10 |
NZ561374A (en) | 2009-02-28 |
EP1871787A2 (en) | 2008-01-02 |
JP2008537749A (en) | 2008-09-25 |
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