WO2006107963A3 - Process for preparing dipeptide amides - Google Patents

Process for preparing dipeptide amides Download PDF

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Publication number
WO2006107963A3
WO2006107963A3 PCT/US2006/012497 US2006012497W WO2006107963A3 WO 2006107963 A3 WO2006107963 A3 WO 2006107963A3 US 2006012497 W US2006012497 W US 2006012497W WO 2006107963 A3 WO2006107963 A3 WO 2006107963A3
Authority
WO
WIPO (PCT)
Prior art keywords
dipeptide amides
preparing
preparing dipeptide
amides
octahydro
Prior art date
Application number
PCT/US2006/012497
Other languages
French (fr)
Other versions
WO2006107963A2 (en
Inventor
Prasad Koteswara Kapa
Joseph Mckenna
Wen-Chung Shieh
Song Xue
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Prasad Koteswara Kapa
Joseph Mckenna
Wen-Chung Shieh
Song Xue
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Prasad Koteswara Kapa, Joseph Mckenna, Wen-Chung Shieh, Song Xue filed Critical Novartis Ag
Publication of WO2006107963A2 publication Critical patent/WO2006107963A2/en
Publication of WO2006107963A3 publication Critical patent/WO2006107963A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Abstract

The present invention provides a new method of making compounds of the formula (I) with anticancer activity, particularly N-[1-cyclohexyl-2-oxo-2-(6-phenethyl-octahydro-pyrrolo[2,3-c]pyridin-1-yl)-ethyl]-2-methylamino-propionamide and related compounds.
PCT/US2006/012497 2005-04-06 2006-04-04 Process for preparing dipeptide amides WO2006107963A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66865905P 2005-04-06 2005-04-06
US60/668,659 2005-04-06

Publications (2)

Publication Number Publication Date
WO2006107963A2 WO2006107963A2 (en) 2006-10-12
WO2006107963A3 true WO2006107963A3 (en) 2007-05-18

Family

ID=36956141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/012497 WO2006107963A2 (en) 2005-04-06 2006-04-04 Process for preparing dipeptide amides

Country Status (1)

Country Link
WO (1) WO2006107963A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610259B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 The FXa inhibitor of amide containing and nitrogen heterocyclic structure, preparation method and its usage
CN104610257B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 The FXa inhibitor of one class amide containing structure, preparation method and its usage

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052850A2 (en) * 2002-12-09 2004-06-24 Bristol-Myers Squibb Company Methods and compounds producing dipeptidyl peptidase iv inhibitors and intermediates thereof
EP1586566A1 (en) * 2004-03-29 2005-10-19 Politechnika Lodzka P-toluenosulfonate salt of N-Methyl-N-(3,5-dimathoxy-2,4,6-triazinyl-1-)-morpholine and related compounds for use as condensing reagent in peptide synthesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052850A2 (en) * 2002-12-09 2004-06-24 Bristol-Myers Squibb Company Methods and compounds producing dipeptidyl peptidase iv inhibitors and intermediates thereof
EP1586566A1 (en) * 2004-03-29 2005-10-19 Politechnika Lodzka P-toluenosulfonate salt of N-Methyl-N-(3,5-dimathoxy-2,4,6-triazinyl-1-)-morpholine and related compounds for use as condensing reagent in peptide synthesis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DEMARCUS M ET AL: "Small ring constrained peptidomimetics. Synthesis of epoxy peptidomimetics, inhibitors of cysteine proteases.", THE JOURNAL OF ORGANIC CHEMISTRY 9 FEB 2001, vol. 66, no. 3, 9 February 2001 (2001-02-09), pages 697 - 706, XP002422337, ISSN: 0022-3263 *
FALCHI A ET AL: "4-(4,6-DIMETHOXY1,3,5,TRIAZIN-2-YL)-4-METHYL-MORPHOLINIUM CHLORIDE (DMTMM): A VALUABLE ALTERNATIVE TO PYBOP FOR SOLID PHASE PEPTIDE SYNTHESIS", SYNLETT, THIEME INTERNATIONAL, STUTTGART, DE, no. 2, 2000, pages 275 - 277, XP001050305, ISSN: 0936-5214 *
MELONI M M ET AL: "Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach.", ORGANIC LETTERS 8 FEB 2001, vol. 3, no. 3, 8 February 2001 (2001-02-08), pages 337 - 340, XP002422336, ISSN: 1523-7060 *

Also Published As

Publication number Publication date
WO2006107963A2 (en) 2006-10-12

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