WO2006106558A3 - Use of nothobranchius furzeri as a model system for the characterisation of genes that control ageing - Google Patents

Use of nothobranchius furzeri as a model system for the characterisation of genes that control ageing Download PDF

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Publication number
WO2006106558A3
WO2006106558A3 PCT/IT2006/000238 IT2006000238W WO2006106558A3 WO 2006106558 A3 WO2006106558 A3 WO 2006106558A3 IT 2006000238 W IT2006000238 W IT 2006000238W WO 2006106558 A3 WO2006106558 A3 WO 2006106558A3
Authority
WO
WIPO (PCT)
Prior art keywords
characterisation
genes
model system
control ageing
nothobranchius furzeri
Prior art date
Application number
PCT/IT2006/000238
Other languages
French (fr)
Other versions
WO2006106558A2 (en
Inventor
Alessandro Cellerino
Original Assignee
Lay Line Genomics Spa
Alessandro Cellerino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lay Line Genomics Spa, Alessandro Cellerino filed Critical Lay Line Genomics Spa
Publication of WO2006106558A2 publication Critical patent/WO2006106558A2/en
Publication of WO2006106558A3 publication Critical patent/WO2006106558A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

The present invention relates to a method for the characterisation and identification of genes or gene products which can modulate the onset of pathologies linked with ageing based on the comparison of various populations of the fish belonging to the family of Cyprinodontids (common name: killifish).
PCT/IT2006/000238 2005-04-07 2006-04-07 Use of nothobranchius furzeri as a model system for the characterisation of genes that control ageing WO2006106558A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000169A ITRM20050169A1 (en) 2005-04-07 2005-04-07 USE OF NOTHOBRANCHIUS FURZERI AS A MODEL SYSTEM FOR THE CHARACTERIZATION OF GENES AND MEDICINES THAT CONTROL AGING.
ITRM2005A000169 2005-04-07

Publications (2)

Publication Number Publication Date
WO2006106558A2 WO2006106558A2 (en) 2006-10-12
WO2006106558A3 true WO2006106558A3 (en) 2007-03-15

Family

ID=36579492

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/IT2005/000753 WO2006106544A2 (en) 2005-04-07 2005-12-22 Use of nothobranchius furzeri as a model system for the characterization of drugs that control ageing
PCT/IT2006/000238 WO2006106558A2 (en) 2005-04-07 2006-04-07 Use of nothobranchius furzeri as a model system for the characterisation of genes that control ageing

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/IT2005/000753 WO2006106544A2 (en) 2005-04-07 2005-12-22 Use of nothobranchius furzeri as a model system for the characterization of drugs that control ageing

Country Status (3)

Country Link
EP (1) EP1871427A2 (en)
IT (1) ITRM20050169A1 (en)
WO (2) WO2006106544A2 (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009509A2 (en) * 2000-07-31 2002-02-07 Regents Of The University Of Minnesota Inhibition of gene expression using polynucleotide analogues
WO2002055666A2 (en) * 2001-01-10 2002-07-18 Childrens Medical Center Method for identifying genes involved in cell proliferation
US20020174447A1 (en) * 2001-01-23 2002-11-21 Greenspan Ralph J. Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease
WO2003052106A1 (en) * 2001-12-17 2003-06-26 Children's Medical Center Corporation Method of screening compounds
WO2004023867A2 (en) * 2002-09-11 2004-03-25 Dana-Farber Cancer Institute Transgenic cancer models in fish
WO2004066723A1 (en) * 2003-01-28 2004-08-12 Daniolabs Limited A model of bone disease amenable to high-throughput screening
WO2004082374A1 (en) * 2003-03-19 2004-09-30 Victor Chang Cardiac Research Institute Limited Model for muscular dystrophy and cardiomyopathy
WO2005075668A1 (en) * 2004-02-03 2005-08-18 Hybrid Biosciences Pty Ltd Method of identifying genes which promote hybrid vigour and hybrid debility and uses thereof
WO2005103694A2 (en) * 2004-04-26 2005-11-03 Daniolabs Limited Methods and fish models for identifying agents for treating bone and joint disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH692837A5 (en) * 1997-07-02 2002-11-29 Lisapharma Spa A pharmaceutical composition for use in foodstuffs, dietetic or medicinal product suitable to improve the oral absorption of the polyphenols and particularly of resveratrol present in grapes and in its p
JP4383533B2 (en) * 1998-02-23 2009-12-16 フィロニクス ファーマシューティカルズ， インコーポレイテッド Methods for screening drugs for activity using pearl fish
WO2002013598A2 (en) * 2000-08-17 2002-02-21 U.S. Army Medical Research And Materiel Command Fish hatching method and apparatus
US20060018833A1 (en) * 2004-04-07 2006-01-26 Randall Murphy Method and system for screening compounds for muscular and/or neurological activity in animals

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009509A2 (en) * 2000-07-31 2002-02-07 Regents Of The University Of Minnesota Inhibition of gene expression using polynucleotide analogues
WO2002055666A2 (en) * 2001-01-10 2002-07-18 Childrens Medical Center Method for identifying genes involved in cell proliferation
US20020174447A1 (en) * 2001-01-23 2002-11-21 Greenspan Ralph J. Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease
WO2003052106A1 (en) * 2001-12-17 2003-06-26 Children's Medical Center Corporation Method of screening compounds
WO2004023867A2 (en) * 2002-09-11 2004-03-25 Dana-Farber Cancer Institute Transgenic cancer models in fish
WO2004066723A1 (en) * 2003-01-28 2004-08-12 Daniolabs Limited A model of bone disease amenable to high-throughput screening
WO2004082374A1 (en) * 2003-03-19 2004-09-30 Victor Chang Cardiac Research Institute Limited Model for muscular dystrophy and cardiomyopathy
WO2005075668A1 (en) * 2004-02-03 2005-08-18 Hybrid Biosciences Pty Ltd Method of identifying genes which promote hybrid vigour and hybrid debility and uses thereof
WO2005103694A2 (en) * 2004-04-26 2005-11-03 Daniolabs Limited Methods and fish models for identifying agents for treating bone and joint disease

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
COOPER ET AL: "Progress towards understanding disease mechanisms in small vertebrate models of neuronal ceroid lipofuscinosis", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, AMSTERDAM, NL, vol. 1762, no. 10, October 2006 (2006-10-01), pages 873 - 889, XP005717617, ISSN: 0925-4439 *
GENADE T. ET AL: "Annual fishes of the genus Nothobranchius as a model system for aging research", AGING CELL, vol. 4, July 2005 (2005-07-01), pages 223 - 233, XP008072177, ISSN: 1474-9718 *
KISHI S.: "Functional aging and gradual senescence in zebrafish", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1019, 2004, pages 521 - 526, XP008072168, ISSN: 0077-8923 *
TERZIBASI E. ET AL: "The short-lived fish Nothobranchius furzeri as a new model system for aging studies", EXPERIMENTAL GERONTOLOGY, 2006, pages 1 - 9, XP002410022 *
VALDESALICI S. ET AL: "Extremely short lifespan in the annual fish Nothobranchius furzeri", PROC R SOC LOND B, vol. 270, no. Suppl, 2003, pages S189 - S191, XP008072214 *

Also Published As

Publication number Publication date
ITRM20050169A1 (en) 2006-10-08
WO2006106544A2 (en) 2006-10-12
WO2006106544A3 (en) 2007-05-18
WO2006106558A2 (en) 2006-10-12
EP1871427A2 (en) 2008-01-02

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