WO2006102533A3 - Pharmaceutically active lipid-based formulation of nucleoside-lipid conjugates - Google Patents
Pharmaceutically active lipid-based formulation of nucleoside-lipid conjugates Download PDFInfo
- Publication number
- WO2006102533A3 WO2006102533A3 PCT/US2006/010638 US2006010638W WO2006102533A3 WO 2006102533 A3 WO2006102533 A3 WO 2006102533A3 US 2006010638 W US2006010638 W US 2006010638W WO 2006102533 A3 WO2006102533 A3 WO 2006102533A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleoside
- lipid
- methods
- pharmaceutically active
- based formulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel formulations of nucleoside-lipid conjugates, the methods of preparing them and the methods for administering them are provided. More particularly, methods for making liposomal formulations of nucleoside-cardiolipin and analogues thereof are provided. By encapsulating nucleoside prodrugs, drugs are protected from degradation, thereby extending the drugs' plasma half-life and intracellular release. In addition, compositions that demonstrate greater efficacy and higher cytotoxicity are produced. Accordingly, nucleoside-lipid conjugates that demonstrate greater in-vitro and in-vivo activity are produced.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66460105P | 2005-03-23 | 2005-03-23 | |
US60/664,601 | 2005-03-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006102533A2 WO2006102533A2 (en) | 2006-09-28 |
WO2006102533A3 true WO2006102533A3 (en) | 2007-12-13 |
Family
ID=37024639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/010638 WO2006102533A2 (en) | 2005-03-23 | 2006-03-23 | Pharmaceutically active lipid-based formulation of nucleoside-lipid conjugates |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006102533A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO20053519L (en) * | 2005-07-18 | 2007-01-19 | Thia Medica As | Use of compounds comprising fatty acids |
WO2011084610A1 (en) * | 2009-12-16 | 2011-07-14 | Children Medical Center Corporation | Liposomes for preventing the spread of hiv |
CN102144981B (en) * | 2011-04-07 | 2013-02-27 | 海南锦瑞制药股份有限公司 | Gemcitabine hydrochloride lyophilized powder injection and preparation method thereof |
EP2815241A2 (en) * | 2012-02-15 | 2014-12-24 | Basf Se | Means and methods for assessing bone disorders |
KR102363946B1 (en) | 2015-03-06 | 2022-02-17 | 아테아 파마슈티컬즈, 인크. | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for the treatment of HCV |
EP4088725A1 (en) | 2016-09-07 | 2022-11-16 | ATEA Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for the treatment of a virus from the picornaviridae family |
UA127407C2 (en) | 2017-02-01 | 2023-08-16 | Атеа Фармасеутікалс, Інк. | Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus |
JP2021521118A (en) | 2018-04-10 | 2021-08-26 | アテア ファーマシューティカルズ, インコーポレイテッド | Treatment of HCV-infected patients with cirrhosis |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004017944A1 (en) * | 2002-08-23 | 2004-03-04 | Neopharm, Inc. | Liposomal gemcitabine compositions for better drug delivery |
-
2006
- 2006-03-23 WO PCT/US2006/010638 patent/WO2006102533A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004017944A1 (en) * | 2002-08-23 | 2004-03-04 | Neopharm, Inc. | Liposomal gemcitabine compositions for better drug delivery |
Non-Patent Citations (2)
Title |
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ALI ET AL.: "Synthesis and biological evaluation of gemicitabine-lipid conjugate (NEO6002)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, 2005, pages 2571 - 2574, XP004866838 * |
IMMORDINO ET AL.: "Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing liposomes containing lipophilic gemicitabine prodrugs", JOURNAL OF CONTROLLED RELEASE, vol. 100, no. 3, 2004, pages 331 - 346, XP004656456 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006102533A2 (en) | 2006-09-28 |
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