WO2006102068A3 - Methods and compositions for derepression of iap-inhibited caspase - Google Patents

Methods and compositions for derepression of iap-inhibited caspase Download PDF

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Publication number
WO2006102068A3
WO2006102068A3 PCT/US2006/009695 US2006009695W WO2006102068A3 WO 2006102068 A3 WO2006102068 A3 WO 2006102068A3 US 2006009695 W US2006009695 W US 2006009695W WO 2006102068 A3 WO2006102068 A3 WO 2006102068A3
Authority
WO
WIPO (PCT)
Prior art keywords
iap
inhibited caspase
derepression
compositions
methods
Prior art date
Application number
PCT/US2006/009695
Other languages
French (fr)
Other versions
WO2006102068A2 (en
Inventor
John C Reed
Rihcard A Houghten
Adel Nefzi
John M Ostresh
Clemencia Pinilla
Kate Welsh
Original Assignee
Burnham Inst
Torrey Pines Inst
John C Reed
Rihcard A Houghten
Adel Nefzi
John M Ostresh
Clemencia Pinilla
Kate Welsh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/084,714 external-priority patent/US20070003535A1/en
Application filed by Burnham Inst, Torrey Pines Inst, John C Reed, Rihcard A Houghten, Adel Nefzi, John M Ostresh, Clemencia Pinilla, Kate Welsh filed Critical Burnham Inst
Priority to EP06738724A priority Critical patent/EP1865977A2/en
Priority to CA002601653A priority patent/CA2601653A1/en
Priority to US11/886,385 priority patent/US20110183358A1/en
Priority to JP2008502089A priority patent/JP2008537735A/en
Priority to US11/910,606 priority patent/US8299041B2/en
Publication of WO2006102068A2 publication Critical patent/WO2006102068A2/en
Priority to US11/982,317 priority patent/US20090043099A1/en
Publication of WO2006102068A3 publication Critical patent/WO2006102068A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides

Abstract

The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
PCT/US2006/009695 2005-03-17 2006-03-17 Methods and compositions for derepression of iap-inhibited caspase WO2006102068A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06738724A EP1865977A2 (en) 2005-03-17 2006-03-17 Methods and compositions for derepression of iap-inhibited caspase
CA002601653A CA2601653A1 (en) 2005-03-17 2006-03-17 Methods and compositions for derepression of iap-inhibited caspase
US11/886,385 US20110183358A1 (en) 2005-03-17 2006-03-17 Methods and compositions for derepression of iap-inhibited caspase
JP2008502089A JP2008537735A (en) 2005-03-17 2006-03-17 Methods and compositions for derepression of IAP-inhibited caspases
US11/910,606 US8299041B2 (en) 2005-04-08 2006-04-10 Compositions and their uses directed to acetyl-CoA carboxylases
US11/982,317 US20090043099A1 (en) 2006-03-17 2007-10-31 Methods and compositions for derepression of IAP-inhibited caspase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/084,714 2005-03-17
US11/084,714 US20070003535A1 (en) 2005-03-17 2005-03-17 Methods and compositions for derepression of IAP-inhibited caspase
US11/186,629 2005-07-19
US11/186,629 US7217688B2 (en) 2005-03-17 2005-07-19 Methods and compositions for derepression of IAP-inhibited caspase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/982,317 Continuation-In-Part US20090043099A1 (en) 2006-03-17 2007-10-31 Methods and compositions for derepression of IAP-inhibited caspase

Publications (2)

Publication Number Publication Date
WO2006102068A2 WO2006102068A2 (en) 2006-09-28
WO2006102068A3 true WO2006102068A3 (en) 2009-06-11

Family

ID=37024414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/009695 WO2006102068A2 (en) 2005-03-17 2006-03-17 Methods and compositions for derepression of iap-inhibited caspase

Country Status (3)

Country Link
EP (1) EP1865977A2 (en)
CA (1) CA2601653A1 (en)
WO (1) WO2006102068A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060258581A1 (en) * 2001-11-21 2006-11-16 Reed John C Methods and composition for derepressions of IAP-inhibited caspase
WO2020047361A1 (en) * 2018-08-30 2020-03-05 University Of Central Florida Research Foundation, Inc. Amino acid depletion agents as antiproliferative agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006180A (en) * 1973-10-12 1977-02-01 Merck & Co., Inc. [1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids
US20050119176A1 (en) * 2001-11-21 2005-06-02 The Burnham Institute Methods and compositions for derepression of IAP-inhibited caspase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006180A (en) * 1973-10-12 1977-02-01 Merck & Co., Inc. [1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids
US20050119176A1 (en) * 2001-11-21 2005-06-02 The Burnham Institute Methods and compositions for derepression of IAP-inhibited caspase

Also Published As

Publication number Publication date
WO2006102068A2 (en) 2006-09-28
EP1865977A2 (en) 2007-12-19
CA2601653A1 (en) 2006-09-28

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