WO2006099351A3 - Hydrocodone polymorphs - Google Patents

Hydrocodone polymorphs Download PDF

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Publication number
WO2006099351A3
WO2006099351A3 PCT/US2006/008990 US2006008990W WO2006099351A3 WO 2006099351 A3 WO2006099351 A3 WO 2006099351A3 US 2006008990 W US2006008990 W US 2006008990W WO 2006099351 A3 WO2006099351 A3 WO 2006099351A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrocodone
polymorphs
hydrocodone bitartrate
replacements
useful
Prior art date
Application number
PCT/US2006/008990
Other languages
French (fr)
Other versions
WO2006099351A2 (en
Inventor
Eric J Hagen
Aeri Park
Original Assignee
Noramco Inc
Eric J Hagen
Aeri Park
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noramco Inc, Eric J Hagen, Aeri Park filed Critical Noramco Inc
Priority to EP06738095A priority Critical patent/EP1861406A2/en
Priority to CA002621943A priority patent/CA2621943A1/en
Priority to AU2006223129A priority patent/AU2006223129A1/en
Priority to JP2008501047A priority patent/JP2008533049A/en
Priority to MX2007011192A priority patent/MX2007011192A/en
Publication of WO2006099351A2 publication Critical patent/WO2006099351A2/en
Publication of WO2006099351A3 publication Critical patent/WO2006099351A3/en
Priority to IL185801A priority patent/IL185801A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Hydrocodone bitartrate forms are disclosed which are useful as analgesic agents either in combination with or as replacements for hydrocodone bitartrate.
PCT/US2006/008990 2005-03-11 2006-03-08 Hydrocodone polymorphs WO2006099351A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06738095A EP1861406A2 (en) 2005-03-11 2006-03-08 Hydrocodone polymorphs
CA002621943A CA2621943A1 (en) 2005-03-11 2006-03-08 Hydrocodone polymorphs
AU2006223129A AU2006223129A1 (en) 2005-03-11 2006-03-08 Hydrocodone polymorphs
JP2008501047A JP2008533049A (en) 2005-03-11 2006-03-08 Hydrocodone polymorph
MX2007011192A MX2007011192A (en) 2005-03-11 2006-03-08 Hydrocodone polymorphs.
IL185801A IL185801A0 (en) 2005-03-11 2007-09-06 Hydrocodone polymorphs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66064505P 2005-03-11 2005-03-11
US60/660,645 2005-03-11

Publications (2)

Publication Number Publication Date
WO2006099351A2 WO2006099351A2 (en) 2006-09-21
WO2006099351A3 true WO2006099351A3 (en) 2007-02-22

Family

ID=36685874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/008990 WO2006099351A2 (en) 2005-03-11 2006-03-08 Hydrocodone polymorphs

Country Status (9)

Country Link
EP (1) EP1861406A2 (en)
JP (1) JP2008533049A (en)
KR (1) KR20070119672A (en)
CN (1) CN101171253A (en)
AU (1) AU2006223129A1 (en)
CA (1) CA2621943A1 (en)
IL (1) IL185801A0 (en)
MX (1) MX2007011192A (en)
WO (1) WO2006099351A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201419454D0 (en) * 2014-10-31 2014-12-17 Cambrex Charles City Inc New process

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2544291A (en) * 1949-04-05 1951-03-06 New York Quinine And Chemical Alkaloid manufacture
US2577947A (en) * 1951-12-11 Manufacture of dihydrocodeinone
EP0900582A1 (en) * 1997-08-21 1999-03-10 Johnson Matthey Public Limited Company Method for removal of residual organic solvents from a crystalline bulk substance and use thereof in manufacturing pharmaceuticals
WO2005100361A1 (en) * 2004-04-13 2005-10-27 Zentiva, A.S. A METHOD OF PREPARATION OF 4,5α-EPOXY-6-OXOMORPHINAN DERIVATIVES
WO2006052456A1 (en) * 2004-10-27 2006-05-18 Mallinckrodt Inc. Method for separation and purification of hydrocodone by preparative chromatography

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2577947A (en) * 1951-12-11 Manufacture of dihydrocodeinone
US2544291A (en) * 1949-04-05 1951-03-06 New York Quinine And Chemical Alkaloid manufacture
EP0900582A1 (en) * 1997-08-21 1999-03-10 Johnson Matthey Public Limited Company Method for removal of residual organic solvents from a crystalline bulk substance and use thereof in manufacturing pharmaceuticals
WO2005100361A1 (en) * 2004-04-13 2005-10-27 Zentiva, A.S. A METHOD OF PREPARATION OF 4,5α-EPOXY-6-OXOMORPHINAN DERIVATIVES
WO2006052456A1 (en) * 2004-10-27 2006-05-18 Mallinckrodt Inc. Method for separation and purification of hydrocodone by preparative chromatography

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BRITAIN ET AL: "Polymorphism in Pharmaceutical Solids passage", POLYMORPHISM IN PHARMACEUTICAL SOLIDS, 1999, pages 235 - 238, XP002278123 *
BUDAVARI S ET AL (ED): "4806. Hydrocodone", MERCK INDEX. ENCYCLOPEDIA OF CHEMICALS, DRUGS, AND BIOLOGICALS. 13TH. EDITION 2001, WHITEHOUSE STATION, MERCK & CO, US, vol. ED. 13, 2001, pages 854 - 855, XP002394988, ISBN: 0-911910-12-3 *
CAIRA M R: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1998, pages 163 - 208, XP001156954, ISSN: 0340-1022 *
PARFITT K (ED): "Hydrocodone Tartrate", MARTINDALE : THE COMPLETE DRUG REFERENCE. (FORMERLY MARTINDALE THE EXTRA PHARMACOPOEIA), LONDON : PHARMACEUTICAL PRESS, GB, 1999, pages 43, XP002394987, ISBN: 0-85369-429-X *
W.H. BARNES, H.M. SHEPPARD: "PHYSICAL METHODS FOR THE IDENTIFICATION OF NARCOTICS (CONT.). Part IIB. X-Ray Diffraction Powder Data for Eighty-Three Narcotics", BULLETIN ON NARCOTICS, 1954, pages 27 - 68, XP009070139 *

Also Published As

Publication number Publication date
AU2006223129A2 (en) 2006-09-21
KR20070119672A (en) 2007-12-20
EP1861406A2 (en) 2007-12-05
IL185801A0 (en) 2008-01-06
JP2008533049A (en) 2008-08-21
MX2007011192A (en) 2007-11-21
AU2006223129A1 (en) 2006-09-21
WO2006099351A2 (en) 2006-09-21
CA2621943A1 (en) 2006-09-21
CN101171253A (en) 2008-04-30

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