WO2006097694A3 - Peptide synthesis supported by a soluble polymer - Google Patents

Peptide synthesis supported by a soluble polymer Download PDF

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Publication number
WO2006097694A3
WO2006097694A3 PCT/GB2006/000864 GB2006000864W WO2006097694A3 WO 2006097694 A3 WO2006097694 A3 WO 2006097694A3 GB 2006000864 W GB2006000864 W GB 2006000864W WO 2006097694 A3 WO2006097694 A3 WO 2006097694A3
Authority
WO
WIPO (PCT)
Prior art keywords
soluble polymer
peptide synthesis
unprotected
terminal
synthesis supported
Prior art date
Application number
PCT/GB2006/000864
Other languages
French (fr)
Other versions
WO2006097694A2 (en
Inventor
Ram Prakash Sharma
Patrick Kanda
Original Assignee
Activotec Spp Ltd
Ram Prakash Sharma
Patrick Kanda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Activotec Spp Ltd, Ram Prakash Sharma, Patrick Kanda filed Critical Activotec Spp Ltd
Publication of WO2006097694A2 publication Critical patent/WO2006097694A2/en
Publication of WO2006097694A3 publication Critical patent/WO2006097694A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Abstract

A process for preparing a peptide or protein by solid phase synthesis comprising combining a sequence including one or more amino acids linked to a first resin via the C terminal, with an amino acid sequence including one or more amino acids linked to a soluble polymer via the N terminal so as to create a native peptide link between unprotected N and unprotected C terminals of said amino acid sequences.
PCT/GB2006/000864 2005-03-14 2006-03-13 Peptide synthesis supported by a soluble polymer WO2006097694A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0505199.0 2005-03-14
GBGB0505199.0A GB0505199D0 (en) 2005-03-14 2005-03-14 Process

Publications (2)

Publication Number Publication Date
WO2006097694A2 WO2006097694A2 (en) 2006-09-21
WO2006097694A3 true WO2006097694A3 (en) 2007-02-22

Family

ID=34509026

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/000864 WO2006097694A2 (en) 2005-03-14 2006-03-13 Peptide synthesis supported by a soluble polymer

Country Status (2)

Country Link
GB (1) GB0505199D0 (en)
WO (1) WO2006097694A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569993B1 (en) * 1998-04-15 2003-05-27 Aventis Pharma S.A. Process for the preparation of resin-bound cyclic peptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569993B1 (en) * 1998-04-15 2003-05-27 Aventis Pharma S.A. Process for the preparation of resin-bound cyclic peptides

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BENZ H: "THE ROLE OF SOLID-PHASE FRAGMENT CONDENSATION (SPFC) IN PEPTIDE SYNTHESIS", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE, no. 4, 1994, pages 337 - 358, XP002314852, ISSN: 0039-7881 *
LU Y-A ET AL: "PEGYLATED PEPTIDES I: SOLID-PHASE SYNTHESIS OF NALPHA-PEGYLATED PEPTIDES USING FMOC STRATEGY", PEPTIDE RESEARCH, NATICK, MA, US, vol. 6, no. 3, 1993, pages 140 - 146, XP001012727, ISSN: 1040-5704 *
MUTTER M, OPPLIGER H, ZIER A: "SOLUBILIZING PROTECTING GROUPS IN PEPTIDE-SYNTHESIS - EFFECT OF SIDE-CHAIN-ATTACHED POLY(ETHYLENE GLYCOL) DERIVATIVES UPON BETA-SHEET FORMATION OF MODEL PEPTIDES", MAKROMOLEKULARE CHEMIE-RAPID COMMUNICATIONS, vol. 13, no. 3, March 1992 (1992-03-01), pages 151 - 157, XP002381395 *
OPPLIGER H: "ENTWICKLUNG SOLUBILISIERENDER SCHUTZGRUPPEN FUER DIE PEPTIDSYNTHESE UND DEREN EINFLUSS AUF DIE SEKUNDAERSTRUKTURBILDING VON MODELLPEPTIDEN / L'INTRODUCTION DES GROUPES PROTECTEURS SOLUBLES DANS LA CHIMIE PEPTIDIQUE ET LEUR INFLUENCE POUR LA FORMATION D'UNE STRUCTURE SECONDAIRE D'UN PEPTIDE MODELE", DISSERTATION, XX, XX, 1991, pages 182pages, XP007901223 *
ZIER A ET AL: "POLYETHYLENE GLYCOL BOUND BENZYL- AND FLUORENYL DERIVATIVES AS SOLUBILIZING SIDE-CHAIN PROTECTING GROUPS IN PEPTIDE SYNTHESIS", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 7, 1994, pages 1039 - 1042, XP002950143, ISSN: 0040-4039 *
ZIER A: "DERIVES DE POLYETHYLENE GLYCOL EN TANT QUE GROUPES PROTECTEURS D'AMINO ACIDES SOLUBLES ET LEUR APPLICATION DANS LES STRATEGIES CONVERGENTES DE LA SYNTHESE PEPTIDIQUE POLYETHYLENGLYKOLDERIVATE ALS SOLUBILISIERENDE ANIMOSAEURE-SEITENSCHUTZGRUPPEN UND DEREN ANWENDUNG IN DER KONVERGENTEN SYNTHESESTRATEG", THESIS, XX, XX, 1992, pages 142pages, XP007901222 *

Also Published As

Publication number Publication date
WO2006097694A2 (en) 2006-09-21
GB0505199D0 (en) 2005-04-20

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