WO2006094201A3 - Semicarbazide-sensitive amide oxidase inhibitors - Google Patents

Semicarbazide-sensitive amide oxidase inhibitors Download PDF

Info

Publication number
WO2006094201A3
WO2006094201A3 PCT/US2006/007626 US2006007626W WO2006094201A3 WO 2006094201 A3 WO2006094201 A3 WO 2006094201A3 US 2006007626 W US2006007626 W US 2006007626W WO 2006094201 A3 WO2006094201 A3 WO 2006094201A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
semicarbazide
oxidase inhibitors
compositions
treatment
Prior art date
Application number
PCT/US2006/007626
Other languages
French (fr)
Other versions
WO2006094201A2 (en
Inventor
Luisa Maria Salter-Cid
Eric Y Wang
Keith Cockerill
Matthew D Linnik
Edward J Victoria
Original Assignee
Jolla Pharma
Luisa Maria Salter-Cid
Eric Y Wang
Keith Cockerill
Matthew D Linnik
Edward J Victoria
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jolla Pharma, Luisa Maria Salter-Cid, Eric Y Wang, Keith Cockerill, Matthew D Linnik, Edward J Victoria filed Critical Jolla Pharma
Publication of WO2006094201A2 publication Critical patent/WO2006094201A2/en
Publication of WO2006094201A3 publication Critical patent/WO2006094201A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylhydrazine compounds, hydroxylamine (aminooxy) compounds, and other compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis.
PCT/US2006/007626 2005-03-02 2006-03-02 Semicarbazide-sensitive amide oxidase inhibitors WO2006094201A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65811005P 2005-03-02 2005-03-02
US60/658,110 2005-03-02

Publications (2)

Publication Number Publication Date
WO2006094201A2 WO2006094201A2 (en) 2006-09-08
WO2006094201A3 true WO2006094201A3 (en) 2006-12-21

Family

ID=36941863

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/007626 WO2006094201A2 (en) 2005-03-02 2006-03-02 Semicarbazide-sensitive amide oxidase inhibitors

Country Status (1)

Country Link
WO (1) WO2006094201A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011504485A (en) 2007-11-21 2011-02-10 ファーマクシス リミテッド SSAO / VAP-1 haloallylamine inhibitors and uses thereof
UA112154C2 (en) 2009-09-08 2016-08-10 Біоті Терапіс Корп. Use of vap-1 inhibitors for treating fibrotic conditions
CA2776480A1 (en) 2009-10-20 2011-04-28 Pfizer Inc. Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators
FI20115234A0 (en) 2011-03-08 2011-03-08 Biotie Therapies Corp New pyridazinone and pyridone compounds
GB201304526D0 (en) 2013-03-13 2013-04-24 Proximagen Ltd New compounds
WO2014199171A1 (en) 2013-06-12 2014-12-18 Proximagen Limited New therapeutic uses of enzyme inhibitors
EP3131539B1 (en) 2014-04-15 2018-12-05 Pécsi Tudományegyetem Semicarbazide-sensitive amine oxidase inhibitors for use as analgesics in traumatic neuropathy and neurogenic inflammation
WO2015189534A1 (en) 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
AU2016366635A1 (en) 2015-12-07 2018-06-21 Benevolentai Cambridge Limited VAP-1 inhibitors for treating pain
CN110366547B (en) 2017-03-01 2023-02-17 勃林格殷格翰国际有限公司 Transition metal catalyzed photodecarboxylation of alpha-haloacrylic acid derivatives
GB201709136D0 (en) * 2017-06-08 2017-07-26 Proximagen Ltd New therapeutic uses of enzyme inhibitors
CN111233782A (en) * 2019-11-27 2020-06-05 重庆大学 Asymmetric synthesis method for preparing 1, 2-azaoxetane compound

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3952008A (en) * 1973-04-17 1976-04-20 Bayer Aktiengesellschaft Pyrazol-5-ones
US4107326A (en) * 1977-05-06 1978-08-15 American Cyanamid Company Novel benzylideneaminoguanidines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3952008A (en) * 1973-04-17 1976-04-20 Bayer Aktiengesellschaft Pyrazol-5-ones
US4107326A (en) * 1977-05-06 1978-08-15 American Cyanamid Company Novel benzylideneaminoguanidines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZIRKLE C.L. ET AL.: "2-substituted cyclopropylamines", J. OF MEDICINAL & PHARMACEUTICAL CHEMISTRY, vol. 5, 1962, pages 1265 - 1284, XP009038812 *

Also Published As

Publication number Publication date
WO2006094201A2 (en) 2006-09-08

Similar Documents

Publication Publication Date Title
WO2007120528A3 (en) Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
WO2005014530A3 (en) Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment of diseases
WO2006094201A3 (en) Semicarbazide-sensitive amide oxidase inhibitors
WO2005082343A3 (en) Amines and amides for the treatment of diseases
WO2007061661A3 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
WO2007087068A3 (en) Inhibitors of tyrosine kinases and uses thereof
WO2005028475A3 (en) Compositions useful as inhibitors of protein kinases
EP1485381B8 (en) Azolylaminoazine as inhibitors of protein kinases
WO2005034998A3 (en) Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
AU2003220299A1 (en) Azinylaminoazoles as inhibitors of protein kinases
AU2003218215A1 (en) Azolylaminoazines as inhibitors of protein kinases
AU2003220300A1 (en) Compositions useful as inhibitors of protein kinases
WO2005103050A3 (en) Azaindoles useful as inhibitors of rock and other protein kinases
EP1712239A3 (en) Interleukin-1 inhibitors in the treatment of diseases
EP2537849A3 (en) Azaindoles useful as inhibitors of janus kinases
WO2006055871A3 (en) Treatment for multiple sclerosis
WO2006003388A8 (en) Compositions and methods for treating inflammatory disorders
WO2006042150A8 (en) Diaminoalkane aspartic protease inhibitors
WO2003072035A8 (en) Compositions and methods for the treatment of immune related diseases
WO2004041170A9 (en) Compositions and methods for the treatment of immune related diseases
TW200633980A (en) Pyridones useful as inhibitors of kinases
WO2007061862A3 (en) 2-keto-oxazoles as modulators of fatty acid amide hydrolase
WO2004024097A9 (en) Compositions and methods for the treatment of immune related diseases
WO2006030439A3 (en) Compositions and methods for inducing hair growth
UA84929C2 (en) Prodrugs of pyrrolylpyrimidine erk protein kinase inhibitors

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06736876

Country of ref document: EP

Kind code of ref document: A2