WO2006094120A3 - Treatment for embolic stroke - Google Patents

Treatment for embolic stroke Download PDF

Info

Publication number
WO2006094120A3
WO2006094120A3 PCT/US2006/007412 US2006007412W WO2006094120A3 WO 2006094120 A3 WO2006094120 A3 WO 2006094120A3 US 2006007412 W US2006007412 W US 2006007412W WO 2006094120 A3 WO2006094120 A3 WO 2006094120A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
stroke
agent
amount sufficient
embolic stroke
Prior art date
Application number
PCT/US2006/007412
Other languages
French (fr)
Other versions
WO2006094120A2 (en
Inventor
Paul A Lapchak
Dalia Araujo
Justin A Zivin
Original Assignee
Univ California
Paul A Lapchak
Dalia Araujo
Justin A Zivin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Paul A Lapchak, Dalia Araujo, Justin A Zivin filed Critical Univ California
Publication of WO2006094120A2 publication Critical patent/WO2006094120A2/en
Priority to US11/693,125 priority Critical patent/US20070167419A1/en
Priority to US11/693,418 priority patent/US20070166299A1/en
Publication of WO2006094120A3 publication Critical patent/WO2006094120A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided herein are methods of treating stroke that include contacting a subject suffering from a stroke with an agent that increases reperfusion of an affected area in an amount sufficient to allow for the penetration of a spin trap agent; and further contacting the subject with a spin trap agent in an amount sufficient to reduce cell and/or tissue damage. The method further includes optionally administering an NMDA receptor antagonist and a polyphenolic antioxidant.
PCT/US2006/007412 2005-03-02 2006-03-01 Treatment for embolic stroke WO2006094120A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/693,125 US20070167419A1 (en) 2005-03-02 2007-03-29 Treatment for embolic stroke
US11/693,418 US20070166299A1 (en) 2005-03-02 2007-03-29 Treatment for embolic stroke

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65827405P 2005-03-02 2005-03-02
US60/658,274 2005-03-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/693,418 Continuation-In-Part US20070166299A1 (en) 2005-03-02 2007-03-29 Treatment for embolic stroke
US11/693,125 Continuation-In-Part US20070167419A1 (en) 2005-03-02 2007-03-29 Treatment for embolic stroke

Publications (2)

Publication Number Publication Date
WO2006094120A2 WO2006094120A2 (en) 2006-09-08
WO2006094120A3 true WO2006094120A3 (en) 2009-04-23

Family

ID=36941818

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/007412 WO2006094120A2 (en) 2005-03-02 2006-03-01 Treatment for embolic stroke

Country Status (1)

Country Link
WO (1) WO2006094120A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080107641A1 (en) 2006-08-29 2008-05-08 Genentech, Inc. Method of treating stroke with thrombolytic agent
GB0819958D0 (en) * 2008-10-31 2008-12-10 Provexis Natural Products Ltd Therapeutic compositions
GB0819959D0 (en) 2008-10-31 2008-12-10 Provexis Natural Products Ltd Fruit extracts
MY171723A (en) * 2010-12-23 2019-10-24 Gennova Biopharmaceuticals Ltd Pharmaceutical compositions of tenecteplase
TR201815457T4 (en) 2012-04-23 2018-11-21 Univ Oslo Use of tomato extract as antihypertensive agent and process for producing water-soluble sugar-free tomato extract.
GB201223365D0 (en) 2012-12-24 2013-02-06 Provexis Natural Products Ltd Compositions
JP7104032B2 (en) 2016-11-02 2022-07-20 プロヴェクシス ナチュラル プロダクツ リミテッド Protection of water-soluble tomato extract against adverse effects of air pollution
CN106668865B (en) * 2017-01-23 2019-07-23 牡丹江医学院 For treating pharmaceutical composition, preparation and its application of cerebral ischemia
WO2022178423A1 (en) * 2021-02-22 2022-08-25 Oklahoma Medical Research Foundation Okn-007 as an agent to improve longevity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020098179A1 (en) * 2000-10-17 2002-07-25 Brearley Christopher John Pharmaceutical combinations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020098179A1 (en) * 2000-10-17 2002-07-25 Brearley Christopher John Pharmaceutical combinations

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FOLEY ET AL., FREE RADICAL BIOLOGY & MEDICINE, vol. 26, no. 9/10, 1999, pages 1202 - 1208 *
LAPCHAK ET AL., STROKE, vol. 33, 2002, pages 1411 - 1415 *
LAPCHAK, P. A, BRAIN RESEARCH, vol. 997, February 2004 (2004-02-01), pages 152 - 158 *
LAPCHAK, P. A., EXPERT OPIN. INVESTIG. DRUGS, vol. 11, no. 11, 2002, pages 1623 - 1632 *

Also Published As

Publication number Publication date
WO2006094120A2 (en) 2006-09-08

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