WO2006091767A3 - Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors - Google Patents

Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors Download PDF

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Publication number
WO2006091767A3
WO2006091767A3 PCT/US2006/006513 US2006006513W WO2006091767A3 WO 2006091767 A3 WO2006091767 A3 WO 2006091767A3 US 2006006513 W US2006006513 W US 2006006513W WO 2006091767 A3 WO2006091767 A3 WO 2006091767A3
Authority
WO
WIPO (PCT)
Prior art keywords
articles
compositions
manufacture
methods
contributing
Prior art date
Application number
PCT/US2006/006513
Other languages
French (fr)
Other versions
WO2006091767A2 (en
Inventor
Anil Gulati
Original Assignee
Spectrum Pharmaceuticals Inc
Univ Illinois
Anil Gulati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrum Pharmaceuticals Inc, Univ Illinois, Anil Gulati filed Critical Spectrum Pharmaceuticals Inc
Priority to CA002598439A priority Critical patent/CA2598439A1/en
Priority to JP2007557176A priority patent/JP2008531589A/en
Priority to EP06748250A priority patent/EP1858539A2/en
Publication of WO2006091767A2 publication Critical patent/WO2006091767A2/en
Publication of WO2006091767A3 publication Critical patent/WO2006091767A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2285—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Methods, compositions and articles of manufacture for contributing to the treatment of a solid cancerous tumor are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery of a chemotherapeutic agent to a solid tumor in mammals, including humans.
PCT/US2006/006513 2005-02-22 2006-02-22 Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors WO2006091767A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002598439A CA2598439A1 (en) 2005-02-22 2006-02-22 Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors
JP2007557176A JP2008531589A (en) 2005-02-22 2006-02-22 Methods, compositions and products for contributing to the treatment of solid tumors
EP06748250A EP1858539A2 (en) 2005-02-22 2006-02-22 Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US65565605P 2005-02-22 2005-02-22
US65564305P 2005-02-22 2005-02-22
US65565405P 2005-02-22 2005-02-22
US60/655,654 2005-02-22
US60/655,643 2005-02-22
US60/655,656 2005-02-22

Publications (2)

Publication Number Publication Date
WO2006091767A2 WO2006091767A2 (en) 2006-08-31
WO2006091767A3 true WO2006091767A3 (en) 2006-12-28

Family

ID=36617185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/006513 WO2006091767A2 (en) 2005-02-22 2006-02-22 Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors

Country Status (4)

Country Link
EP (1) EP1858539A2 (en)
JP (2) JP2008531589A (en)
CA (1) CA2598439A1 (en)
WO (1) WO2006091767A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8026216B2 (en) 2002-10-24 2011-09-27 Spectrum Pharmaceuticals, Inc. Methods and compositions for contributing to the treatment of cancers
US8217010B2 (en) 2002-10-24 2012-07-10 The Board Of Trustees Of The University Of Illinois Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors
US20070032422A1 (en) * 2002-10-24 2007-02-08 Spectrum Pharmaceuticals, Inc. Methods, compositions and articles of manufacture for contributing to the treatment of cancers
CN101534852B (en) 2006-08-31 2013-02-13 光谱医药公司 Sensitization of tumor cells to radiation therapy through the administration of endothelin agonists
WO2008127996A1 (en) * 2007-04-13 2008-10-23 Spectrum Pahrmaceuticals, Inc. Methods and compositions for contributing to the treatment of cancers
US9308235B2 (en) 2012-05-09 2016-04-12 Spectrum Pharmaceuticals, Inc. Treatment of primary and metastatic carcinoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040138121A1 (en) * 2002-10-24 2004-07-15 Anil Gulati Method and composition for preventing and treating solid tumors

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BATTISTINI, B. AND BOTTING, R.: "Endothelins: a quantum leap forward", DRUG NEWS & PERSPECTIVES, vol. 8, no. 6, August 1995 (1995-08-01), pages 365 - 391, XP009029183 *
BELL, K.M. ET AL.: "Effect of endothelin-1 and sarafotoxin S6c on blood flow in a rat tumor", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 26, no. s3, 1995, pages s222 - s225, XP009029149 *
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1983, TAKITA H: "Effect of vasodilators in experimental solid tumor chemotherapy", XP002403130, Database accession no. EMB-1983229301 *
DAVENPORT A P ET AL: "Classification of endothelin receptors and antagonists in clinical development", CLINICAL SCIENCE, BIOCHEMICAL SOCIETY AND THE MEDICAL RESEARCH SOCIETY, LONDON,, GB, vol. 103, no. S48, August 2002 (2002-08-01), pages 1S - 3, XP002277110, ISSN: 0143-5221 *
JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH 1983 ITALY, vol. 2, no. 1, 1983, pages 47 - 48 *
RAI AARATI ET AL: "ETB receptor agonist, IRL 1620, does not affect paclitaxel plasma pharmacokinetics in breast tumour bearing rats", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 57, no. 7, July 2005 (2005-07-01), pages 869 - 876, XP008066451, ISSN: 0022-3573 *
RAI, A. AND GULATI, A.: "Evidence for the involvement of ETB receptors in ET-1-induced changes in blood flow to the rat breast tumor", CANCER CHEMOTHER PHARMACOL, vol. 51, 8 November 2002 (2002-11-08), pages 21 - 28, XP001180771 *
RAJESHKUMAR N V ET AL: "Endothelin B receptor agonist, IRL 1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats", BREAST CANCER RESEARCH AND TREATMENT, vol. 94, no. 3, December 2005 (2005-12-01), pages 237 - 247, XP002403127, ISSN: 0167-6806 *
RAJESHKUMAR N V: "ENDOTELIN B RECEPTOR AGONIST, IRL 1260, INCREASES BLOOD PERFUSION AND ENHANCES PACLITAXEL DELIVERY TO TUMOR", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, vol. 96, April 2005 (2005-04-01), pages 1349, XP008066444, ISSN: 0197-016X *
UNIVERSITY OF ILLINOIS AT CHICAGO: "List of Posters Presentations in 2004 AAPS Annual Meeting (Baltimore)", pages 1 - 4, XP002403128, Retrieved from the Internet <URL:http://www2.uic.edu/stud_orgs/prof/aaps/posters.htm> [retrieved on 20061016] *

Also Published As

Publication number Publication date
JP2008531589A (en) 2008-08-14
EP1858539A2 (en) 2007-11-28
JP2012214519A (en) 2012-11-08
CA2598439A1 (en) 2006-08-31
WO2006091767A2 (en) 2006-08-31

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