WO2006090114A3 - Imaging of particles using evanescent radiation - Google Patents

Imaging of particles using evanescent radiation Download PDF

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Publication number
WO2006090114A3
WO2006090114A3 PCT/GB2006/000497 GB2006000497W WO2006090114A3 WO 2006090114 A3 WO2006090114 A3 WO 2006090114A3 GB 2006000497 W GB2006000497 W GB 2006000497W WO 2006090114 A3 WO2006090114 A3 WO 2006090114A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
radiation
different
areas
bound
Prior art date
Application number
PCT/GB2006/000497
Other languages
French (fr)
Other versions
WO2006090114A2 (en
Inventor
Sean Anthony Gillespie
Original Assignee
Smiths Group Plc
Sean Anthony Gillespie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smiths Group Plc, Sean Anthony Gillespie filed Critical Smiths Group Plc
Publication of WO2006090114A2 publication Critical patent/WO2006090114A2/en
Publication of WO2006090114A3 publication Critical patent/WO2006090114A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

An optical detector for particles, such as biological particles, has a transparent prism (1) with an upper surface (10) treated differently, such as with different antibodies, in several areas (17, 18, 19) so that different particles bind to different ones of the areas. A source (30) of monochromatic radiation directs a beam through a second face (11) so that it is incident on the underside of the upper surface (10) at an angle close to the angle of total internal reflection. Most of the radiation is reflected away from the upper surface and is absorbed in a radiation sink (32) on the third face (12) of the prism (1). Some of the radiation, however, is scattered by any particles bound to the antibody-treated areas. A magnifying viewer (40) mounted above the upper surface (10) enables identification of particles because of the different appearance of the area (17) to which the particles are bound.
PCT/GB2006/000497 2005-02-24 2006-02-13 Imaging of particles using evanescent radiation WO2006090114A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0503767.6 2005-02-24
GBGB0503767.6A GB0503767D0 (en) 2005-02-24 2005-02-24 Particle detection

Publications (2)

Publication Number Publication Date
WO2006090114A2 WO2006090114A2 (en) 2006-08-31
WO2006090114A3 true WO2006090114A3 (en) 2006-12-07

Family

ID=34401202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/000497 WO2006090114A2 (en) 2005-02-24 2006-02-13 Imaging of particles using evanescent radiation

Country Status (2)

Country Link
GB (1) GB0503767D0 (en)
WO (1) WO2006090114A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110749A (en) * 1996-03-01 2000-08-29 Beckman Coulter, Inc. System for simultaneously conducting multiple ligand binding assays
WO2001042768A1 (en) * 1999-12-07 2001-06-14 The Secretary Of State For Defence Surface plasmon resonance
US6280960B1 (en) * 1997-06-13 2001-08-28 Robert Carr Optical detection and analysis of sub-micron particles
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110749A (en) * 1996-03-01 2000-08-29 Beckman Coulter, Inc. System for simultaneously conducting multiple ligand binding assays
US6280960B1 (en) * 1997-06-13 2001-08-28 Robert Carr Optical detection and analysis of sub-micron particles
WO2001042768A1 (en) * 1999-12-07 2001-06-14 The Secretary Of State For Defence Surface plasmon resonance
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry

Also Published As

Publication number Publication date
GB0503767D0 (en) 2005-03-30
WO2006090114A2 (en) 2006-08-31

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