WO2006089406A8 - Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents - Google Patents

Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents

Info

Publication number
WO2006089406A8
WO2006089406A8 PCT/CA2006/000248 CA2006000248W WO2006089406A8 WO 2006089406 A8 WO2006089406 A8 WO 2006089406A8 CA 2006000248 W CA2006000248 W CA 2006000248W WO 2006089406 A8 WO2006089406 A8 WO 2006089406A8
Authority
WO
WIPO (PCT)
Prior art keywords
anti
cancer
compositions
useful
compounds
Prior art date
Application number
PCT/CA2006/000248
Other languages
French (fr)
Other versions
WO2006089406A1 (en
Inventor
Giorgio Attardo
Pierre Beauparlant
Laurent Belec
Lionel Dumas
Samuel Fortin
Gerson Gonzalez
Daniel Rabouin
Sasmita Tripathy
Original Assignee
Giorgio Attardo
Pierre Beauparlant
Laurent Belec
Lionel Dumas
Samuel Fortin
Galileo Pharmaceuticals Inc
Gemin X Biotechnologies Inc
Gerson Gonzalez
Daniel Rabouin
Sasmita Tripathy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US65561305P priority Critical
Priority to US60/655,613 priority
Application filed by Giorgio Attardo, Pierre Beauparlant, Laurent Belec, Lionel Dumas, Samuel Fortin, Galileo Pharmaceuticals Inc, Gemin X Biotechnologies Inc, Gerson Gonzalez, Daniel Rabouin, Sasmita Tripathy filed Critical Giorgio Attardo
Publication of WO2006089406A1 publication Critical patent/WO2006089406A1/en
Publication of WO2006089406A8 publication Critical patent/WO2006089406A8/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring heteroatom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals substituted by singly or doubly bound oxygen atoms
    • C07D303/32Compounds containing oxirane rings with hydrocarbon radicals substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals

Abstract

The present invention relates to diterpenoid compounds of formula (I) and compositions comprising an effective amount of a diterpenoid compound according to formula (I), compounds of formula (I) wherein A, B, D or E can either represent a nitrogen atom or a carbon atom which is optionally subsituted. There are also disclosed methods useful for treating or preventing cancer or neoplastic disorders comprising administering an effective amount of a diterpenoid compound. The present compounds, compositions, and methods thereof are further useful for treating or preventing fungal infections. They are also useful for inhibiting the growth of a cancer cell or neoplastic cell, for inducing apoptosis in a cancer or neoplastic cell or useful for inhibiting the growth of a fungus.
PCT/CA2006/000248 2005-02-22 2006-02-20 Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents WO2006089406A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US65561305P true 2005-02-22 2005-02-22
US60/655,613 2005-02-22

Publications (2)

Publication Number Publication Date
WO2006089406A1 WO2006089406A1 (en) 2006-08-31
WO2006089406A8 true WO2006089406A8 (en) 2007-04-05

Family

ID=36926992

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2006/000248 WO2006089406A1 (en) 2005-02-22 2006-02-20 Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents

Country Status (1)

Country Link
WO (1) WO2006089406A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9000188B2 (en) 2008-07-22 2015-04-07 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US9174941B2 (en) 2010-12-17 2015-11-03 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5530686B2 (en) * 1974-01-11 1980-08-13
BR0214520A (en) * 2001-11-29 2006-05-30 Taro Pharmaceuticals Usa Inc Method for the preparation of corticosteroid-fluoro 6alpha
US20060167086A1 (en) * 2003-02-14 2006-07-27 Kazuo Umezawa Medicinal composition

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9000188B2 (en) 2008-07-22 2015-04-07 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US9174941B2 (en) 2010-12-17 2015-11-03 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof

Also Published As

Publication number Publication date
WO2006089406A1 (en) 2006-08-31

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