WO2006089406A8 - Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents - Google Patents
Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agentsInfo
- Publication number
- WO2006089406A8 WO2006089406A8 PCT/CA2006/000248 CA2006000248W WO2006089406A8 WO 2006089406 A8 WO2006089406 A8 WO 2006089406A8 CA 2006000248 W CA2006000248 W CA 2006000248W WO 2006089406 A8 WO2006089406 A8 WO 2006089406A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cancer
- compositions
- useful
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
The present invention relates to diterpenoid compounds of formula (I) and compositions comprising an effective amount of a diterpenoid compound according to formula (I), compounds of formula (I) wherein A, B, D or E can either represent a nitrogen atom or a carbon atom which is optionally subsituted. There are also disclosed methods useful for treating or preventing cancer or neoplastic disorders comprising administering an effective amount of a diterpenoid compound. The present compounds, compositions, and methods thereof are further useful for treating or preventing fungal infections. They are also useful for inhibiting the growth of a cancer cell or neoplastic cell, for inducing apoptosis in a cancer or neoplastic cell or useful for inhibiting the growth of a fungus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65561305P | 2005-02-22 | 2005-02-22 | |
US60/655,613 | 2005-02-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006089406A1 WO2006089406A1 (en) | 2006-08-31 |
WO2006089406A8 true WO2006089406A8 (en) | 2007-04-05 |
Family
ID=36926992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2006/000248 WO2006089406A1 (en) | 2005-02-22 | 2006-02-20 | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006089406A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9000188B2 (en) | 2008-07-22 | 2015-04-07 | Trustees Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
US9174941B2 (en) | 2010-12-17 | 2015-11-03 | Reata Pharmaceuticals, Inc. | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2974726C (en) | 2015-02-12 | 2023-09-19 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant inflammation modulators |
JP7177059B2 (en) | 2016-12-16 | 2022-11-22 | リアタ ファーマシューティカルズ インコーポレイテッド | Pyrimidine tricyclic enone derivatives for inhibition of RORγ and other uses |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5530686B2 (en) * | 1974-01-11 | 1980-08-13 | ||
CA2473471A1 (en) * | 2001-11-29 | 2003-06-12 | Taro Pharmaceuticals U.S.A., Inc. | Method for the preparation of 6-alpha-fluoro corticosteroids |
EP1600445A4 (en) * | 2003-02-14 | 2008-06-11 | Signal Creation Inc | Medicinal composition |
-
2006
- 2006-02-20 WO PCT/CA2006/000248 patent/WO2006089406A1/en not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9000188B2 (en) | 2008-07-22 | 2015-04-07 | Trustees Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
US9174941B2 (en) | 2010-12-17 | 2015-11-03 | Reata Pharmaceuticals, Inc. | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2006089406A1 (en) | 2006-08-31 |
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