WO2006088976A3 - Fiber-optic biosensor and biosensing methods - Google Patents

Fiber-optic biosensor and biosensing methods Download PDF

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Publication number
WO2006088976A3
WO2006088976A3 PCT/US2006/005376 US2006005376W WO2006088976A3 WO 2006088976 A3 WO2006088976 A3 WO 2006088976A3 US 2006005376 W US2006005376 W US 2006005376W WO 2006088976 A3 WO2006088976 A3 WO 2006088976A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical waveguide
target
wavelength
fiber
bind
Prior art date
Application number
PCT/US2006/005376
Other languages
French (fr)
Other versions
WO2006088976A2 (en
WO2006088976A8 (en
Inventor
Kyung Aih Kang
Chong H Ahn
Original Assignee
Univ Louisville Res Found
Kyung Aih Kang
Chong H Ahn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/190,199 external-priority patent/US7871573B2/en
Application filed by Univ Louisville Res Found, Kyung Aih Kang, Chong H Ahn filed Critical Univ Louisville Res Found
Publication of WO2006088976A2 publication Critical patent/WO2006088976A2/en
Publication of WO2006088976A8 publication Critical patent/WO2006088976A8/en
Publication of WO2006088976A3 publication Critical patent/WO2006088976A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

A method for biosensing that includes passing, via convective flow, a sample believed to contain one or more target biomarkers through a micro fluidic channel and over the surface of an optical waveguide that has been prepared to bind the one or more target biomarkers, and sensing for an emission output from the optical waveguide at a wavelength that is characteristic of the binding of the target biomarker. A biosensor device that includes a module defining at least one microfluidic channel, an optical waveguide exposed along at least a portion of its length to fluid flow within the microfluidic channel, where a surface of the optical waveguide being prepared to bind a target biomarker, and an excitation source to couple an excitation wavelength of light into the optical waveguide. The device also includes a sensor for detecting emission light from the optical waveguide at an emission wavelength characteristic of binding of the target biomarker.
PCT/US2006/005376 2005-02-16 2006-02-16 Fiber-optic biosensor and biosensing methods WO2006088976A2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US65354305P 2005-02-16 2005-02-16
US60/653,543 2005-02-16
US11/190,199 2005-07-26
US11/190,199 US7871573B2 (en) 2004-07-26 2005-07-26 Enhancement of sensitivity of fluorophore mediated biosensing and bioimaging
US11/355,467 2006-02-16

Publications (3)

Publication Number Publication Date
WO2006088976A2 WO2006088976A2 (en) 2006-08-24
WO2006088976A8 WO2006088976A8 (en) 2006-10-19
WO2006088976A3 true WO2006088976A3 (en) 2009-08-20

Family

ID=36917028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/005376 WO2006088976A2 (en) 2005-02-16 2006-02-16 Fiber-optic biosensor and biosensing methods

Country Status (1)

Country Link
WO (1) WO2006088976A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022279968A1 (en) * 2021-05-27 2023-12-14 Advanced Instrument Pte. Ltd Microfluidics system, instrument, and cartridge including self-aligning optical fiber system and method

Citations (13)

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US5327225A (en) * 1993-01-28 1994-07-05 The Center For Innovative Technology Surface plasmon resonance sensor
US5527686A (en) * 1991-07-29 1996-06-18 Serex, Inc. Differential binding affinities and dissociation assays based thereon
US5601991A (en) * 1993-02-17 1997-02-11 Cardiovascular Diagnostics, Inc. Dry chemistry cascade immunoassay and affinity assay
US5811250A (en) * 1993-03-24 1998-09-22 Nycomed Pharma A/S Method of diagnosing haemastatic disorders
US6048722A (en) * 1995-11-08 2000-04-11 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
US6124138A (en) * 1996-04-03 2000-09-26 The Perkin-Elmer Corporation Method for multiple analyte detection
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US6200762B1 (en) * 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
US20020160400A1 (en) * 2001-02-14 2002-10-31 Lakowicz Joseph R. Radiative decay engineering
US20020179448A1 (en) * 2001-06-04 2002-12-05 Lauks Imants R. Integrated electrokinetic devices and methods of manufacture
US20020197631A1 (en) * 2001-04-26 2002-12-26 Lawrence Nathan P. Multichamber device and uses thereof for processing of biological samples
US20030148401A1 (en) * 2001-11-09 2003-08-07 Anoop Agrawal High surface area substrates for microarrays and methods to make same
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527686A (en) * 1991-07-29 1996-06-18 Serex, Inc. Differential binding affinities and dissociation assays based thereon
US5327225A (en) * 1993-01-28 1994-07-05 The Center For Innovative Technology Surface plasmon resonance sensor
US5601991A (en) * 1993-02-17 1997-02-11 Cardiovascular Diagnostics, Inc. Dry chemistry cascade immunoassay and affinity assay
US5811250A (en) * 1993-03-24 1998-09-22 Nycomed Pharma A/S Method of diagnosing haemastatic disorders
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US6048722A (en) * 1995-11-08 2000-04-11 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
US6124138A (en) * 1996-04-03 2000-09-26 The Perkin-Elmer Corporation Method for multiple analyte detection
US6200762B1 (en) * 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
US20020160400A1 (en) * 2001-02-14 2002-10-31 Lakowicz Joseph R. Radiative decay engineering
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20020197631A1 (en) * 2001-04-26 2002-12-26 Lawrence Nathan P. Multichamber device and uses thereof for processing of biological samples
US20020179448A1 (en) * 2001-06-04 2002-12-05 Lauks Imants R. Integrated electrokinetic devices and methods of manufacture
US20030148401A1 (en) * 2001-11-09 2003-08-07 Anoop Agrawal High surface area substrates for microarrays and methods to make same

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DAVIES: "The Immunoassay Handbook", 2001, NATURE PUBLISHING GROUP, NEW YORK, NY, article "introduction to immunoassay principles", pages: 3 - 40 *
KANG: "A rapid, multi-analyte immuno biosensor with passive microfluidics: A model system - four cardiac marker monitoring device", THE FIRST ANNUAL REPORT, 1 January 2004 (2004-01-01) *
KANG: "Rapid, multi-analyte immuno biosensor with passive microfluidics: A model system - four cardiac marker monitoring device", PROPOSAL TO NATIONAL SCIENCE FOUNDATION, 6 March 2003 (2003-03-06) *
SPIKER ET AL.: "Preliminary study of real-time fiber optic based protein C biosensor", BIOTECHNOLOGY & BIOENGINEERING., vol. 66, 1999, pages 158 - 163 *
ULMAN: "Formation and structure of self-assembled monolayers", CHEM. REV., vol. 96, 1996, pages 1533 - 1554 *

Also Published As

Publication number Publication date
WO2006088976A2 (en) 2006-08-24
WO2006088976A8 (en) 2006-10-19

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