WO2006086609A3 - Inhibitors of tryptase - Google Patents

Inhibitors of tryptase Download PDF

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Publication number
WO2006086609A3
WO2006086609A3 PCT/US2006/004680 US2006004680W WO2006086609A3 WO 2006086609 A3 WO2006086609 A3 WO 2006086609A3 US 2006004680 W US2006004680 W US 2006004680W WO 2006086609 A3 WO2006086609 A3 WO 2006086609A3
Authority
WO
WIPO (PCT)
Prior art keywords
tryptase
inhibitors
compounds
pharmaceutical composition
pulmonary disease
Prior art date
Application number
PCT/US2006/004680
Other languages
French (fr)
Other versions
WO2006086609A2 (en
Inventor
Bernard Hirschbein
Chang Sun Lee
Joane Litvak
Weili Liu
Martin Sendzik
Emma J Shelton
Jeffrey R Spencer
David Sperandio
Vincent W-F Tai
Julia Winslow-Lohman
Robert Yee
Original Assignee
Axys Pharm Inc
Bernard Hirschbein
Chang Sun Lee
Joane Litvak
Weili Liu
Martin Sendzik
Emma J Shelton
Jeffrey R Spencer
David Sperandio
Vincent W-F Tai
Julia Winslow-Lohman
Robert Yee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axys Pharm Inc, Bernard Hirschbein, Chang Sun Lee, Joane Litvak, Weili Liu, Martin Sendzik, Emma J Shelton, Jeffrey R Spencer, David Sperandio, Vincent W-F Tai, Julia Winslow-Lohman, Robert Yee filed Critical Axys Pharm Inc
Publication of WO2006086609A2 publication Critical patent/WO2006086609A2/en
Publication of WO2006086609A3 publication Critical patent/WO2006086609A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

The present invention related to certain inhibitors of tryptase that are inhibitors of tryptase, pharmaceutical composition comprising these compounds and method of treating asthma, allergic rhinitis, and/or Chronic Obstructive Pulmonary Disease utilizing these compounds.
PCT/US2006/004680 2005-02-10 2006-02-09 Inhibitors of tryptase WO2006086609A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65187005P 2005-02-10 2005-02-10
US60/651,870 2005-02-10

Publications (2)

Publication Number Publication Date
WO2006086609A2 WO2006086609A2 (en) 2006-08-17
WO2006086609A3 true WO2006086609A3 (en) 2007-02-01

Family

ID=36793742

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/004680 WO2006086609A2 (en) 2005-02-10 2006-02-09 Inhibitors of tryptase

Country Status (1)

Country Link
WO (1) WO2006086609A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9512135B2 (en) 2007-03-12 2016-12-06 Nektar Therapeutics Oligomer-opioid agonist conjugates

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2354124E (en) 2006-12-19 2013-04-09 Hoffmann La Roche Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
PL2807153T3 (en) * 2012-01-25 2020-09-07 Novartis Ag Heterocyclic compounds and methods for their use
EP4083029A1 (en) * 2013-08-20 2022-11-02 University of Washington through its Center for Commercialization Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydroxylase
JP2017528461A (en) * 2014-09-10 2017-09-28 エピザイム インコーポレイテッド Substituted pyrrolidine carboxamide compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942532A (en) * 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942532A (en) * 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9512135B2 (en) 2007-03-12 2016-12-06 Nektar Therapeutics Oligomer-opioid agonist conjugates

Also Published As

Publication number Publication date
WO2006086609A2 (en) 2006-08-17

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