WO2006085228A3 - 9a-carbamoyl-y-aminopropyl and 9a-thiocarbamoyl-y-aminopropyl-azalides with antimalarial activity - Google Patents

9a-carbamoyl-y-aminopropyl and 9a-thiocarbamoyl-y-aminopropyl-azalides with antimalarial activity Download PDF

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Publication number
WO2006085228A3
WO2006085228A3 PCT/IB2006/001227 IB2006001227W WO2006085228A3 WO 2006085228 A3 WO2006085228 A3 WO 2006085228A3 IB 2006001227 W IB2006001227 W IB 2006001227W WO 2006085228 A3 WO2006085228 A3 WO 2006085228A3
Authority
WO
WIPO (PCT)
Prior art keywords
aminopropyl
carbamoyl
thiocarbamoyl
antimalarial activity
azalides
Prior art date
Application number
PCT/IB2006/001227
Other languages
French (fr)
Other versions
WO2006085228A2 (en
Inventor
Krajacic Mirjana Bukvic
Nedjeljko Kujundzic
Zrinka Ivezic
Sulejman Alihodzic
Antun Hutinec
Andrea Fajdetic
Original Assignee
Glaxosmithkline Zagreb
Krajacic Mirjana Bukvic
Nedjeljko Kujundzic
Zrinka Ivezic
Sulejman Alihodzic
Antun Hutinec
Andrea Fajdetic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Zagreb, Krajacic Mirjana Bukvic, Nedjeljko Kujundzic, Zrinka Ivezic, Sulejman Alihodzic, Antun Hutinec, Andrea Fajdetic filed Critical Glaxosmithkline Zagreb
Priority to DE602006013953T priority Critical patent/DE602006013953D1/en
Priority to AT06727593T priority patent/ATE465741T1/en
Priority to EP06727593A priority patent/EP1855696B1/en
Priority to JP2007550878A priority patent/JP2008526949A/en
Priority to US11/813,875 priority patent/US20080200404A1/en
Publication of WO2006085228A2 publication Critical patent/WO2006085228A2/en
Publication of WO2006085228A3 publication Critical patent/WO2006085228A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Novel 9a-N'-substituted-carbamoyl- and tMocarbamoyl-aminoalkyl-9a-aza-9-deoxo- 9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro- 9a-homoerythromycin A compounds having antimalarial activity are claimed. More particularly, the invention relates to 9a-N'-substituted-carbamoyl- and thiocarbamoyl- ß-aminoethyl- or -Ϝ-aminopropyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds and to pharmaceutically acceptable derivatives thereof having antimalarial activity.
PCT/IB2006/001227 2005-01-14 2006-01-13 9a-carbamoyl-y-aminopropyl and 9a-thiocarbamoyl-y-aminopropyl-azalides with antimalarial activity WO2006085228A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE602006013953T DE602006013953D1 (en) 2005-01-14 2006-01-13 9A-CARBAMOYL-Y-AMINOPROPYL AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL AZALIDES WITH ANTIMALARIA ACTIVITY
AT06727593T ATE465741T1 (en) 2005-01-14 2006-01-13 9A-CARBAMOYL-Y-AMINOPROPYL AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL AZALIDES WITH ANTIMALARIA ACTIVITY
EP06727593A EP1855696B1 (en) 2005-01-14 2006-01-13 9a-carbamoyl-y-aminopropyl- and 9a-thiocarbamoyl-y-aminopropyl-azalides with antimalarial activity
JP2007550878A JP2008526949A (en) 2005-01-14 2006-01-13 Novel antimalarial drugs 9a-carbamoyl-aminoalkyl and 9a-thiocarbamoyl-aminoalkyl azalide
US11/813,875 US20080200404A1 (en) 2005-01-14 2006-01-13 Novel Antimalarial 9A-Carbamoyl-Aminoalkyl and 9A-Thiocarbamoyl-Aminoalkyl Azalides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64436005P 2005-01-14 2005-01-14
US60/644,360 2005-01-14

Publications (2)

Publication Number Publication Date
WO2006085228A2 WO2006085228A2 (en) 2006-08-17
WO2006085228A3 true WO2006085228A3 (en) 2007-01-04

Family

ID=36793417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/001227 WO2006085228A2 (en) 2005-01-14 2006-01-13 9a-carbamoyl-y-aminopropyl and 9a-thiocarbamoyl-y-aminopropyl-azalides with antimalarial activity

Country Status (7)

Country Link
US (1) US20080200404A1 (en)
EP (1) EP1855696B1 (en)
JP (1) JP2008526949A (en)
AT (1) ATE465741T1 (en)
DE (1) DE602006013953D1 (en)
ES (1) ES2344518T3 (en)
WO (1) WO2006085228A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE477805T1 (en) * 2005-01-14 2010-09-15 Glaxosmithkline Zagreb 9A-CARBAMOYL-Y-AMINOPROPYL AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL AZALIDES WITH ANTIMALARIA ACTIVITY
US20090105301A1 (en) * 2006-05-03 2009-04-23 Sulejman Alihodzic 9a-substituted azalides for the treatment of malaria
PE20090879A1 (en) * 2007-07-30 2009-07-25 Glaxosmithkline Zagreb 9-DEOXO-9a-METHYL-9a-AZA-9a-HOMOERITHROMYCIN A DERIVATIVES AS ANTIMALARIC AGENTS
TWI486451B (en) * 2013-12-11 2015-06-01 Ind Tech Res Inst Isolated human liver tumor cell line and method of agent screening
TWI461535B (en) * 2013-12-11 2014-11-21 Ind Tech Res Inst Isolated human liver tumor cell line and method of agent screening

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052904A2 (en) * 2002-12-12 2004-06-24 Pliva - Istrazivacki Institut D.O.O. Novel semisynthetic macrolide antibiotics of the azalide series
WO2006075256A2 (en) * 2005-01-14 2006-07-20 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9a-carbamoyl-ϝ-aminopropyl- and 9a-thiocarbamoyl-ϝ-aminopropyl-azalides with antimalarial activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052904A2 (en) * 2002-12-12 2004-06-24 Pliva - Istrazivacki Institut D.O.O. Novel semisynthetic macrolide antibiotics of the azalide series
WO2006075256A2 (en) * 2005-01-14 2006-07-20 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9a-carbamoyl-ϝ-aminopropyl- and 9a-thiocarbamoyl-ϝ-aminopropyl-azalides with antimalarial activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANDERSON S L ET AL: "PROPHYLAXIS OF PLASMODIUM FALCIPARUM MALARIA WITH AZITHROMYCIN ADMINISTERED TO VOLUNTEERS", ANNALS OF INTERNAL MEDICINE, NEW YORK, NY, US, vol. 123, no. 10, 15 November 1995 (1995-11-15), pages 771 - 773, XP008069262, ISSN: 0003-4819 *

Also Published As

Publication number Publication date
ATE465741T1 (en) 2010-05-15
DE602006013953D1 (en) 2010-06-10
EP1855696A2 (en) 2007-11-21
ES2344518T3 (en) 2010-08-30
US20080200404A1 (en) 2008-08-21
JP2008526949A (en) 2008-07-24
EP1855696B1 (en) 2010-04-28
WO2006085228A2 (en) 2006-08-17

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