WO2006084913A3 - Device for treatment of rectal disorders, and manufacturing process for the same, involving nitric oxide - Google Patents

Device for treatment of rectal disorders, and manufacturing process for the same, involving nitric oxide Download PDF

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Publication number
WO2006084913A3
WO2006084913A3 PCT/EP2006/050892 EP2006050892W WO2006084913A3 WO 2006084913 A3 WO2006084913 A3 WO 2006084913A3 EP 2006050892 W EP2006050892 W EP 2006050892W WO 2006084913 A3 WO2006084913 A3 WO 2006084913A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitric oxide
treatment
rectal
manufacturing process
same
Prior art date
Application number
PCT/EP2006/050892
Other languages
French (fr)
Other versions
WO2006084913A2 (en
Inventor
Tor Peters
Original Assignee
Nolabs Ab
Tor Peters
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05002934A external-priority patent/EP1690557A1/en
Application filed by Nolabs Ab, Tor Peters filed Critical Nolabs Ab
Publication of WO2006084913A2 publication Critical patent/WO2006084913A2/en
Publication of WO2006084913A3 publication Critical patent/WO2006084913A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114—Nitric oxide, i.e. NO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules

Abstract

A device for therapeutic treatment of rectal disorders, including fissures, ulcers, haemorrhoids, and levator spasm, is disclosed. The device comprises a nitric oxide (NO) eluting polymer configured for eluting a therapeutic dosage of nitrogen oxide (NO) when used for the treatment. Furthermore, the device is configured for exposing a rectal treatment site of said rectal disorder in or on a rectal region of a body to said nitric oxide when said polymer elutes nitrogen oxide (NO). The nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of said therapeutic dosage of nitric oxide (NO). Moreover a method of manufacturing such a rectal treatment device is disclosed.
PCT/EP2006/050892 2005-02-11 2006-02-13 Device for treatment of rectal disorders, and manufacturing process for the same, involving nitric oxide WO2006084913A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05002934.7 2005-02-11
EP05002934A EP1690557A1 (en) 2005-02-11 2005-02-11 Device for treatment of rectal disorders, and manufacturing process for the same
US65276205P 2005-02-14 2005-02-14
US60/652,762 2005-02-14

Publications (2)

Publication Number Publication Date
WO2006084913A2 WO2006084913A2 (en) 2006-08-17
WO2006084913A3 true WO2006084913A3 (en) 2006-11-16

Family

ID=36677284

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/050892 WO2006084913A2 (en) 2005-02-11 2006-02-13 Device for treatment of rectal disorders, and manufacturing process for the same, involving nitric oxide

Country Status (1)

Country Link
WO (1) WO2006084913A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005215970A1 (en) 2004-02-09 2005-09-09 Noxilizer, Inc. Nitric oxide-releasing molecules
US20090214618A1 (en) 2005-05-27 2009-08-27 Schoenfisch Mark H Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
KR100904207B1 (en) * 2007-06-01 2009-06-25 (주) 태웅메디칼 Coating agent for drug releasing stent, manufacturing method thereof and drug releasing stent coated with the coating agent
GB0821345D0 (en) 2008-11-21 2008-12-31 P Q Silicas Uk Ltd Composition and dressing with nitric oxide
WO2011022680A2 (en) 2009-08-21 2011-02-24 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
WO2012118819A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same
CN107802951A (en) * 2017-11-28 2018-03-16 苏州合利美电子科技有限公司 A kind of storage formula Iodophor cotton swab certainly based on automatic illuminating

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032715A1 (en) * 1994-05-27 1995-12-07 Neptune Pharmaceutical Corporation Nitric oxide donor composition and method for treatment of anal disorders
WO1996035416A1 (en) * 1995-05-10 1996-11-14 Nitromed, Inc. Localized use of nitric oxideadducts to prevent internal tissue damage
US5770645A (en) * 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
WO1999016436A1 (en) * 1997-09-30 1999-04-08 John Rhodes Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome
WO2000035434A2 (en) * 1998-12-14 2000-06-22 Cellegy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
EP1300424A1 (en) * 2001-10-04 2003-04-09 Medtronic AVE Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032715A1 (en) * 1994-05-27 1995-12-07 Neptune Pharmaceutical Corporation Nitric oxide donor composition and method for treatment of anal disorders
WO1996035416A1 (en) * 1995-05-10 1996-11-14 Nitromed, Inc. Localized use of nitric oxideadducts to prevent internal tissue damage
US5770645A (en) * 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
WO1999016436A1 (en) * 1997-09-30 1999-04-08 John Rhodes Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome
WO2000035434A2 (en) * 1998-12-14 2000-06-22 Cellegy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
EP1300424A1 (en) * 2001-10-04 2003-04-09 Medtronic AVE Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REYNOLDS M M ET AL: "Nitric Oxide-Releasing Hydrophobic Polymers: Preparation, Characterization, and Potential Biomedical Applications", FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE, vol. 37, no. 7, 1 October 2004 (2004-10-01), pages 926 - 936, XP004551420, ISSN: 0891-5849 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same

Also Published As

Publication number Publication date
WO2006084913A2 (en) 2006-08-17

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