WO2006082110A3 - Salt taste receptor and its use in an assay for salt taste - Google Patents

Salt taste receptor and its use in an assay for salt taste Download PDF

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Publication number
WO2006082110A3
WO2006082110A3 PCT/EP2006/001075 EP2006001075W WO2006082110A3 WO 2006082110 A3 WO2006082110 A3 WO 2006082110A3 EP 2006001075 W EP2006001075 W EP 2006001075W WO 2006082110 A3 WO2006082110 A3 WO 2006082110A3
Authority
WO
WIPO (PCT)
Prior art keywords
salt taste
disclosed
salt
assay
food products
Prior art date
Application number
PCT/EP2006/001075
Other languages
French (fr)
Other versions
WO2006082110A2 (en
Inventor
Coutre Johannes Le
Christopher Marc Parry
Original Assignee
Nestec Sa
Coutre Johannes Le
Christopher Marc Parry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nestec Sa, Coutre Johannes Le, Christopher Marc Parry filed Critical Nestec Sa
Priority to US11/815,596 priority Critical patent/US20080153120A1/en
Priority to EP06706719A priority patent/EP1848736A2/en
Priority to JP2007553566A priority patent/JP2008529987A/en
Priority to AU2006210156A priority patent/AU2006210156A1/en
Priority to CA002596913A priority patent/CA2596913A1/en
Publication of WO2006082110A2 publication Critical patent/WO2006082110A2/en
Publication of WO2006082110A3 publication Critical patent/WO2006082110A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Seasonings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A functional human salt taste receptor and a cell based assay that simulates human salt taste stimulation is disclosed. A method for the identification of enhancers or modulators of salt taste and food products that contain them is also disclosed. The method for the production of food products with desirable flavor properties having greatly reduced salt concentrations are disclosed. Such foods can provide substantial health benefits in many circumstances thereby providing substantial health benefit.
PCT/EP2006/001075 2005-02-07 2006-02-07 Salt taste receptor and its use in an assay for salt taste WO2006082110A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US11/815,596 US20080153120A1 (en) 2005-02-07 2006-02-07 Salt Taste Receptor and its Use in an Assay for Salt Taste
EP06706719A EP1848736A2 (en) 2005-02-07 2006-02-07 Salt taste receptor and its use in an assay for salt taste
JP2007553566A JP2008529987A (en) 2005-02-07 2006-02-07 Salty taste receptors and their use in salty taste assays
AU2006210156A AU2006210156A1 (en) 2005-02-07 2006-02-07 Salt taste receptor and its use in an assay for salt taste
CA002596913A CA2596913A1 (en) 2005-02-07 2006-02-07 Salt taste receptor and its use in an assay for salt taste

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65094005P 2005-02-07 2005-02-07
US60/650,940 2005-02-07

Publications (2)

Publication Number Publication Date
WO2006082110A2 WO2006082110A2 (en) 2006-08-10
WO2006082110A3 true WO2006082110A3 (en) 2006-11-16

Family

ID=36649823

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/001075 WO2006082110A2 (en) 2005-02-07 2006-02-07 Salt taste receptor and its use in an assay for salt taste

Country Status (6)

Country Link
US (1) US20080153120A1 (en)
EP (1) EP1848736A2 (en)
JP (1) JP2008529987A (en)
AU (1) AU2006210156A1 (en)
CA (1) CA2596913A1 (en)
WO (1) WO2006082110A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008051447A2 (en) 2006-10-19 2008-05-02 Monell Chemical Senses Center Human salty taste receptor and methods of modulating salty taste perception
EP2245057B1 (en) * 2008-01-25 2019-09-04 Chromocell Corporation Novel cell lines expressing enac and methods using them
AU2009215106B2 (en) * 2008-02-01 2015-07-23 Chromocell Corporation Cell lines and methods for making and using them
CN102575279B (en) 2009-09-29 2018-03-20 味之素株式会社 The screening technique of salty taste control substance
RU2662770C2 (en) 2013-01-22 2018-07-30 Марс, Инкорпорейтед Flavour composition and edible compositions containing same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693756A (en) * 1994-02-28 1997-12-02 The Johns Hopkins University Amiloride-sensitive sodium channel and method of identifying substances which stimulate or block salty taste perception
WO2002087306A2 (en) * 2001-05-01 2002-11-07 Senomyx, Inc. High throughput cell-based assay for monitoring sodium channel activity and discovery of salty taste modulating compounds
GB2396414A (en) * 2002-12-20 2004-06-23 Unilever Plc Modulators of human epithelial sodium channels(hENaC)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693756A (en) * 1994-02-28 1997-12-02 The Johns Hopkins University Amiloride-sensitive sodium channel and method of identifying substances which stimulate or block salty taste perception
WO2002087306A2 (en) * 2001-05-01 2002-11-07 Senomyx, Inc. High throughput cell-based assay for monitoring sodium channel activity and discovery of salty taste modulating compounds
GB2396414A (en) * 2002-12-20 2004-06-23 Unilever Plc Modulators of human epithelial sodium channels(hENaC)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
SUZUKI MIKA ET AL: "Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 15, April 2004 (2004-04-01), pages 14899 - 14908, XP002391200, ISSN: 0021-9258 *
TONG ZHENYUE ET AL: "Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 287, no. 5, November 2004 (2004-11-01), pages L928 - L935, XP002391198, ISSN: 1040-0605 *
VUAGNIAUX G ET AL: "SYNERGISTIC ACTIVATION OF ENAC BY THREE MEMBRANE-BOUND CHANNEL-ACTIVATING SERINE PROTEASES (MCAP1, MCAP2, AND MCAP3) AND SERUM- AND GLUCOCORTICOID-REGULATED KINASE (SGK1) IN XENOPUS OOCYTES", JOURNAL OF GENERAL PHYSIOLOGY, ROCKEFELLER INSTITUTE FOR MEDICAL RESEARCH,, US, vol. 120, no. 2, August 2002 (2002-08-01), pages 191 - 201, XP001183248, ISSN: 0022-1295 *
VUAGNIAUX GREGOIRE ET AL: "Activation of the amiloride-sensitive epithelial sodium channel by the serine protease mCAP1 expressed in a mouse cortical collecting duct cell line", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 11, no. 5, May 2000 (2000-05-01), pages 828 - 834, XP002391197, ISSN: 1046-6673 *
WALLRAPP CHRISTINE ET AL: "A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer", CANCER RESEARCH, vol. 60, no. 10, 15 May 2000 (2000-05-15), pages 2602 - 2606, XP002391199, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
US20080153120A1 (en) 2008-06-26
JP2008529987A (en) 2008-08-07
CA2596913A1 (en) 2006-08-10
WO2006082110A2 (en) 2006-08-10
EP1848736A2 (en) 2007-10-31
AU2006210156A1 (en) 2006-08-10

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