WO2006081372A3 - Use of parasitic biological agents for prevention and control of allergic and other ige-mediated disorders - Google Patents

Use of parasitic biological agents for prevention and control of allergic and other ige-mediated disorders Download PDF

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Publication number
WO2006081372A3
WO2006081372A3 PCT/US2006/002822 US2006002822W WO2006081372A3 WO 2006081372 A3 WO2006081372 A3 WO 2006081372A3 US 2006002822 W US2006002822 W US 2006002822W WO 2006081372 A3 WO2006081372 A3 WO 2006081372A3
Authority
WO
WIPO (PCT)
Prior art keywords
ige
immune response
mediated disorders
allergic
prevention
Prior art date
Application number
PCT/US2006/002822
Other languages
French (fr)
Other versions
WO2006081372A2 (en
Inventor
Daniel O'connor
Original Assignee
Milestone Res Inc
Daniel O'connor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Milestone Res Inc, Daniel O'connor filed Critical Milestone Res Inc
Priority to EP06733937A priority Critical patent/EP1853311A2/en
Publication of WO2006081372A2 publication Critical patent/WO2006081372A2/en
Publication of WO2006081372A3 publication Critical patent/WO2006081372A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia

Abstract

The present invention describes using, on a repetitive basis, a non human colonizing helminth compound, in an amount sufficient to establish a transitory parasitic helminth infection and or to simulate in a parasitic helminth infection, thereby having immunosuppressive effect against benign antigens and or stimulating a regulatory immune response characterized by the production of helper cells 2 (Th2), T regulatory helper cells (TREG) and certain cytokines, including, but not limited to interleukin 10 (IL-10), as a therapy or prophylaxis of allergy and other IgE-mediated disorders, which are marked by an inappropriate IgE immune response including, but not limited to an aberrant and or enhanced IgE antibody production to benign antigens. The invention presents using helminth compound by administering it in a frequency and amount sufficient to eliminate or ameliorate the inappropriate immune response in an asthmatic and or allergic individual.
PCT/US2006/002822 2005-01-27 2006-01-27 Use of parasitic biological agents for prevention and control of allergic and other ige-mediated disorders WO2006081372A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06733937A EP1853311A2 (en) 2005-01-27 2006-01-27 Use of parasitic biological agents for prevention and control of allergic and other ige-mediated disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64703205P 2005-01-27 2005-01-27
US60/647,032 2005-01-27

Publications (2)

Publication Number Publication Date
WO2006081372A2 WO2006081372A2 (en) 2006-08-03
WO2006081372A3 true WO2006081372A3 (en) 2007-06-28

Family

ID=36741055

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/002822 WO2006081372A2 (en) 2005-01-27 2006-01-27 Use of parasitic biological agents for prevention and control of allergic and other ige-mediated disorders

Country Status (2)

Country Link
EP (1) EP1853311A2 (en)
WO (1) WO2006081372A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040115223A1 (en) * 2001-05-23 2004-06-17 David Follansbee Prevention and treatment of allergies by helminthic regulation of IgE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040115223A1 (en) * 2001-05-23 2004-06-17 David Follansbee Prevention and treatment of allergies by helminthic regulation of IgE

Also Published As

Publication number Publication date
WO2006081372A2 (en) 2006-08-03
EP1853311A2 (en) 2007-11-14

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