WO2006078229A1 - Serie de microsondes auto-detectrices encastrees destinee a une detection chimique - Google Patents

Serie de microsondes auto-detectrices encastrees destinee a une detection chimique Download PDF

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Publication number
WO2006078229A1
WO2006078229A1 PCT/US2004/034354 US2004034354W WO2006078229A1 WO 2006078229 A1 WO2006078229 A1 WO 2006078229A1 US 2004034354 W US2004034354 W US 2004034354W WO 2006078229 A1 WO2006078229 A1 WO 2006078229A1
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WO
WIPO (PCT)
Prior art keywords
cantilevered probe
cantilevered
probe array
chemical
array
Prior art date
Application number
PCT/US2004/034354
Other languages
English (en)
Inventor
Jesse D. Adams
Original Assignee
Board Of Regents Of The University And Community College System Of Nevada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Board Of Regents Of The University And Community College System Of Nevada filed Critical Board Of Regents Of The University And Community College System Of Nevada
Priority to GB0609690A priority Critical patent/GB2432001B8/en
Publication of WO2006078229A1 publication Critical patent/WO2006078229A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/44—Processing the detected response signal, e.g. electronic circuits specially adapted therefor
    • G01N29/4409—Processing the detected response signal, e.g. electronic circuits specially adapted therefor by comparison
    • G01N29/4418—Processing the detected response signal, e.g. electronic circuits specially adapted therefor by comparison with a model, e.g. best-fit, regression analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/44—Processing the detected response signal, e.g. electronic circuits specially adapted therefor
    • G01N29/46—Processing the detected response signal, e.g. electronic circuits specially adapted therefor by spectral analysis, e.g. Fourier analysis or wavelet analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/01—Indexing codes associated with the measuring variable
    • G01N2291/014—Resonance or resonant frequency
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/01—Indexing codes associated with the measuring variable
    • G01N2291/018—Impedance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0255—(Bio)chemical reactions, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
    • G01N2291/0257—Adsorption, desorption, surface mass change, e.g. on biosensors with a layer containing at least one organic compound
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0427—Flexural waves, plate waves, e.g. Lamb waves, tuning fork, cantilever
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/10—Number of transducers
    • G01N2291/106—Number of transducers one or more transducer arrays

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Signal Processing (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Acoustics & Sound (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Mathematical Physics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

L'invention fournit un système de détection chimique (10) destiné à détecter au moins une espèce chimique cible (12), comprenant une série de sondes auto-détectrices encastrées (20) ayant une pluralité de sondes auto-détectrices encastrées (30), au moins un matériau de revêtement sensible aux produits chimiques (34) appliqué sur au moins une sonde encastrée (30) dans la série de sondes encastrées (20), et un circuit d’interface (40) couplé à la série de sondes encastrées (20). Au moins une sonde encastrée (30) dans la série de sondes encastrées (20) présente une réponse décalée lorsque la série de sondes encastrées (20) est exposée à l'espèce chimique cible (12) et le circuit d'interface (40) actionne la sonde encastrée (30). Un système de détection chimique portable et un procédé de fonctionnement sont également décrits.
PCT/US2004/034354 2003-10-17 2004-10-18 Serie de microsondes auto-detectrices encastrees destinee a une detection chimique WO2006078229A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0609690A GB2432001B8 (en) 2003-10-17 2004-10-18 Self-sensing array of microcantilevers for chemical detection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51250404P 2004-10-17 2004-10-17
US60/512,504 2004-10-17

Publications (1)

Publication Number Publication Date
WO2006078229A1 true WO2006078229A1 (fr) 2006-07-27

Family

ID=36692530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/034354 WO2006078229A1 (fr) 2003-10-17 2004-10-18 Serie de microsondes auto-detectrices encastrees destinee a une detection chimique

Country Status (1)

Country Link
WO (1) WO2006078229A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009060002A1 (fr) * 2007-11-06 2009-05-14 Endress+Hauser Gmbh+Co.Kg Procédé de détermination et/ou de surveillance de la croissance d'une substance biologique dans un milieu au moyen d'un système oscillatoire mécanique
CN109374732A (zh) * 2018-08-14 2019-02-22 杭州超钜科技有限公司 断层逸出气便携式快速测氢装置及其监测方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719324A (en) * 1995-06-16 1998-02-17 Lockheed Martin Energy Systems, Inc. Microcantilever sensor
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
WO2000020850A1 (fr) * 1998-10-07 2000-04-13 Universitá Degli Studi Di Brescia Dispositif a capteurs multiples pour mesures gravimetriques en chimie fonctionnant par le biais de couches piezoelectriques resonnantes selon la technologie des couches epaisses
US6455319B1 (en) * 1999-05-10 2002-09-24 California Institute Of Technology Use of spatiotemporal response behavior in sensor arrays to detect analytes in fluids
US6469293B1 (en) * 1999-03-16 2002-10-22 Seiko Instruments Inc. Multiprobe and scanning probe microscope
US20050016276A1 (en) * 2003-06-06 2005-01-27 Palo Alto Sensor Technology Innovation Frequency encoding of resonant mass sensors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719324A (en) * 1995-06-16 1998-02-17 Lockheed Martin Energy Systems, Inc. Microcantilever sensor
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
WO2000020850A1 (fr) * 1998-10-07 2000-04-13 Universitá Degli Studi Di Brescia Dispositif a capteurs multiples pour mesures gravimetriques en chimie fonctionnant par le biais de couches piezoelectriques resonnantes selon la technologie des couches epaisses
US6469293B1 (en) * 1999-03-16 2002-10-22 Seiko Instruments Inc. Multiprobe and scanning probe microscope
US6455319B1 (en) * 1999-05-10 2002-09-24 California Institute Of Technology Use of spatiotemporal response behavior in sensor arrays to detect analytes in fluids
US20050016276A1 (en) * 2003-06-06 2005-01-27 Palo Alto Sensor Technology Innovation Frequency encoding of resonant mass sensors

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BATTISTON F.M ET AL: "A chemical sensor based on a microfabricated cantilever array with simultaneous resonance-frequency and bending readout", SENSORS AND ACTUATORS, vol. 91, 2000, pages 122 - 131, XP004246538 *
GUAN S. ET AL: "Frequency Encoding of Resonant Mass Sensors for Chemical Vapor Detection", ANALYTICAL CHEMISTRY, vol. 75, 1 September 2003 (2003-09-01), pages 4551 - 4557, XP002985276 *
LANG H.P. ET AL: "Nanomechanics from atomic resolution to molecular recognition based on atomic force microscopy technology", NANOTECHNOLOGY, vol. 13, 2002, pages R29 - R36, XP002985274 *
LANGE D. ET AL: "Complementary metal Oxide Semiconductor Cantilever Arrays on a Single Chip: Mass-Sensitive Detection of Volatile Organic Compounds", ANALYTICAL CHEMISTRY, vol. 74, no. 13, 18 May 2002 (2002-05-18), pages 3084 - 3095, XP001132181 *
LEE C. ET AL: "Smart Force Sensors for Scanning Force Microscopes Using the Micromachined Pieyoelectric PZT Cantilevers", TECHNICAL DIGEST-INTERNATIONAL ELECTRON DEVICES MEETING DECEMBER 1996, December 1996 (1996-12-01), pages 545 - 548, XP010207603 *
MARIE R. ET AL: "Adsorption kinetics and mechanical properties of thiol-modified DNA-oligos on gold investigated by microcantilever sensors", ULTRAMICROSCOPY, vol. 91, 2002, pages 29 - 36, XP002985275 *
ZHOU J.: "Self-excited pieyoelectric microcantilever for gas detection", MICROELECTRONIC ENGINEERING, vol. 69, 2003, pages 37 - 46, XP004440615 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009060002A1 (fr) * 2007-11-06 2009-05-14 Endress+Hauser Gmbh+Co.Kg Procédé de détermination et/ou de surveillance de la croissance d'une substance biologique dans un milieu au moyen d'un système oscillatoire mécanique
DE102007053221B4 (de) * 2007-11-06 2015-08-20 Endress + Hauser Gmbh + Co. Kg Verfahren zur Bestimmung und/oder Überwachung des Wachstums einer biologischen Substanz in einem Medium
CN109374732A (zh) * 2018-08-14 2019-02-22 杭州超钜科技有限公司 断层逸出气便携式快速测氢装置及其监测方法
CN109374732B (zh) * 2018-08-14 2022-01-04 杭州超钜科技有限公司 断层逸出气便携式快速测氢装置及其监测方法

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