WO2006074379A3 - Methods and compositions involving esters of azelaic acid and other dicarboxylic acids - Google Patents

Methods and compositions involving esters of azelaic acid and other dicarboxylic acids Download PDF

Info

Publication number
WO2006074379A3
WO2006074379A3 PCT/US2006/000476 US2006000476W WO2006074379A3 WO 2006074379 A3 WO2006074379 A3 WO 2006074379A3 US 2006000476 W US2006000476 W US 2006000476W WO 2006074379 A3 WO2006074379 A3 WO 2006074379A3
Authority
WO
WIPO (PCT)
Prior art keywords
azelaic acid
carbon atoms
alkyl
esters
derivatives
Prior art date
Application number
PCT/US2006/000476
Other languages
French (fr)
Other versions
WO2006074379A2 (en
Inventor
Robert T Streeper
Chandra U Singh
Original Assignee
Azaya Therapeutics Inc
Robert T Streeper
Chandra U Singh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Azaya Therapeutics Inc, Robert T Streeper, Chandra U Singh filed Critical Azaya Therapeutics Inc
Publication of WO2006074379A2 publication Critical patent/WO2006074379A2/en
Publication of WO2006074379A3 publication Critical patent/WO2006074379A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to formulations of azelaic acid esters and other dicarboxylic acid esters, and their derivatives. In preferred embodiments, the esters have the general Formula (I) wherein R1 and R2 are selected from hydrogen, alkyl groups of up to about 18 carbon atoms and aryl groups of up to about 18 carbon atoms and alkylene group of up to about 18 carbon atoms and an arylene group of up to about 18 carbon atoms. The alkyl, aryl, alkylene and aryl groups may be substituted or unsubstituted, branched or straight chains. In addition, R1 and R2 may contain heteroatoms and may be straight chained or branched, n is an integer from 1-16, and R1 and R2 are not simultaneously hydrogen. R2OOC-(CH2)n-COOR1 (I). The azelaic acid derivatives of Formula (I) of this invention are certain derivatives of azelaic acid and other alkyl geminal diacids which possess a desirable high lipophilicity and biphasic solubility in comparison to the parent compound, azelaic acid, and which are cleaved enzymatically to azelaic acid. Compounds produced from the compounds of Formula (I) by the enzymatic hydrolysis of the R1 and R2 groups are useful as anti-bacterial agents in mammals in vivo and have been contemplated to be used in the treatment of skin disease.
PCT/US2006/000476 2005-01-07 2006-01-06 Methods and compositions involving esters of azelaic acid and other dicarboxylic acids WO2006074379A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64207505P 2005-01-07 2005-01-07
US60/642,075 2005-01-07

Publications (2)

Publication Number Publication Date
WO2006074379A2 WO2006074379A2 (en) 2006-07-13
WO2006074379A3 true WO2006074379A3 (en) 2007-04-12

Family

ID=36648220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/000476 WO2006074379A2 (en) 2005-01-07 2006-01-06 Methods and compositions involving esters of azelaic acid and other dicarboxylic acids

Country Status (1)

Country Link
WO (1) WO2006074379A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090326069A1 (en) * 2008-06-30 2009-12-31 Bltn, Llc Azelaic acid ester compositions and methods for diagnosing and treating tissue conditions using azelaic acid ester compositions and proteinaceous biomarkers
SI3445354T1 (en) 2016-04-20 2022-10-28 New Frontier Labs, Llc Azelaic acid esters in the treatment of insulin resistance
US20210269412A1 (en) * 2018-06-23 2021-09-02 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory skin diseases and cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661519A (en) * 1983-04-12 1987-04-28 Pola Chemical Industries Inc. Method for dermatological application
FR2616430A1 (en) * 1987-06-12 1988-12-16 Oreal New diesters of azelaic acid, process for preparing them, topical compositions containing them and their use in the treatment of acne
US5637305A (en) * 1994-09-08 1997-06-10 Avantgarde S.P.A. L-carnitine salt and cosmetic and pharmaceutical compositions containing same for treating dermatoses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661519A (en) * 1983-04-12 1987-04-28 Pola Chemical Industries Inc. Method for dermatological application
FR2616430A1 (en) * 1987-06-12 1988-12-16 Oreal New diesters of azelaic acid, process for preparing them, topical compositions containing them and their use in the treatment of acne
US5637305A (en) * 1994-09-08 1997-06-10 Avantgarde S.P.A. L-carnitine salt and cosmetic and pharmaceutical compositions containing same for treating dermatoses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 198906, Derwent World Patents Index; AN 1989-041097, XP003009974 *

Also Published As

Publication number Publication date
WO2006074379A2 (en) 2006-07-13

Similar Documents

Publication Publication Date Title
CA2565660A1 (en) Ortho substituted aryl or heteroaryl amide compounds
DE60322889D1 (en) FLUORATED PHOSPHONIC ACIDS
EA201190099A1 (en) (1-PHENYL-2-PYRIDIN-4-IL) ETHYL ESTERS OF BENZOIC ACID AS PHYSHODESTERES INHIBITORS
RU2001102614A (en) New acylated pseudodipeptides, method for their preparation and pharmaceutical compositions containing them
ATE506352T1 (en) METHOD FOR PRODUCING OPTIONAL 2-SUBSTITUTED 1,6-DIHYDRO-6-OXO-4-PYRIMIDINCARBOXYLIC ACIDS
JP2006514610A (en) Furanone derivative and method for producing the same
KR20150129004A (en) Activity-based probe compounds, compositions, and methods of use
WO2009081152A3 (en) Antimicrobial compounds
EP2088140B1 (en) Dihydrazide compounds, preparation and uses thereof
ATE420847T1 (en) SUBSTITUTED PHENYLALKANIC ACID DERIVATIVE AND USE THEREOF
FR2683223A1 (en) (JP) AMPHIPHILE COMPOUNDS WITH DOUBLE HEAD SUGAR SURFACTANT AGENT AND VESICULAR AGENT COMPRISING SUCH A COMPOUND AND PROCESS FOR PREPARING THE SAME.
TN2009000276A1 (en) PROCESS FOR THE MANUFACTURE OF 3-AMINO-TETRAHYDROFURANE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS
WO2006074379A3 (en) Methods and compositions involving esters of azelaic acid and other dicarboxylic acids
ATE422200T1 (en) METHOD FOR PRODUCING SUBSTITUTED NICOTINIC ACID ESTERS
WO2010007363A3 (en) Preparation of fluorine-labelled compounds
EA201170057A1 (en) METHOD FOR PRODUCING SUBSTITUTED 2-AMINOTHIAZOLONES
DE50212728D1 (en) PROCESS FOR THE PREPARATION OF 2-AZETIDINONE DERIVATIVES
WO2003089577A3 (en) Antihelminthic anthraquinones and method of use thereof
KR890014514A (en) Compounds that inhibit the biosynthesis of lipoxygenase-induced metabolites of arachidonic acid
TW200628985A (en) A chemically amplified positive resist composition
FR2900405B1 (en) NOVEL MONOFLUORINE C-GLYCOSIDE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR APPLICATIONS
ES2222822B1 (en) DIAMIDES OF AMINO ACIDS IN NON-ALFA POSITION USEFUL AS ASSISTANTS FOR THE ADMINISTRATION OF ACTIVE BIOLOGICAL AGENTS.
US6602832B2 (en) Oil-soluble additive compositions for lubricating oils
WO2003029228A1 (en) Novel method of preparing nitrogen macrocycles
RU2012109572A (en) N-SULPHATED OLIGOSACCHARIDES, ACTIVATING FGF RECEPTORS, THEIR PRODUCTION AND APPLICATION IN THERAPY

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO COMMUNICATION FORM 1205A HAS BEEN SENT ON16-10-2007)

122 Ep: pct application non-entry in european phase

Ref document number: 06717649

Country of ref document: EP

Kind code of ref document: A2