WO2006069262A3 - Compositions of influenza viral proteins and methods of use thereof - Google Patents

Compositions of influenza viral proteins and methods of use thereof Download PDF

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Publication number
WO2006069262A3
WO2006069262A3 PCT/US2005/046662 US2005046662W WO2006069262A3 WO 2006069262 A3 WO2006069262 A3 WO 2006069262A3 US 2005046662 W US2005046662 W US 2005046662W WO 2006069262 A3 WO2006069262 A3 WO 2006069262A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
influenza viral
methods
viral proteins
fusion proteins
Prior art date
Application number
PCT/US2005/046662
Other languages
French (fr)
Other versions
WO2006069262A2 (en
Inventor
Thomas J Powell
Valerian Nakaar
Langzhou Song
William F Mcdonald
Duane D Hewitt
Original Assignee
Vaxinnate Corp
Thomas J Powell
Valerian Nakaar
Langzhou Song
William F Mcdonald
Duane D Hewitt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaxinnate Corp, Thomas J Powell, Valerian Nakaar, Langzhou Song, William F Mcdonald, Duane D Hewitt filed Critical Vaxinnate Corp
Priority to AU2005319141A priority Critical patent/AU2005319141B8/en
Priority to NZ556004A priority patent/NZ556004A/en
Priority to JP2007547054A priority patent/JP2008524261A/en
Priority to EP05855253A priority patent/EP1831259A2/en
Priority to CA002593746A priority patent/CA2593746A1/en
Priority to BRPI0519705-8A priority patent/BRPI0519705A2/en
Priority to MX2007007586A priority patent/MX2007007586A/en
Publication of WO2006069262A2 publication Critical patent/WO2006069262A2/en
Publication of WO2006069262A3 publication Critical patent/WO2006069262A3/en
Priority to US11/820,148 priority patent/US20090162400A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compositions, fusion proteins and polypeptides comprise at least one pathogen-associated molecular pattern and at least a portion of at least one integral membrane protein of an influenza viral antigen. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject.
PCT/US2005/046662 2004-12-21 2005-12-21 Compositions of influenza viral proteins and methods of use thereof WO2006069262A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2005319141A AU2005319141B8 (en) 2004-12-21 2005-12-21 Compositions of influenza viral proteins and methods of use thereof
NZ556004A NZ556004A (en) 2004-12-21 2005-12-21 Compositions of influenza viral proteins comprising at least one flagellin and at least one influenza M2 protein
JP2007547054A JP2008524261A (en) 2004-12-21 2005-12-21 Composition of influenza virus proteins and methods of use thereof
EP05855253A EP1831259A2 (en) 2004-12-21 2005-12-21 Compositions of influenza viral proteins and methods of use thereof
CA002593746A CA2593746A1 (en) 2004-12-21 2005-12-21 Compositions of influenza viral proteins and methods of use thereof
BRPI0519705-8A BRPI0519705A2 (en) 2004-12-21 2005-12-21 compositions, fusion proteins and methods of stimulating an immune response in an individual
MX2007007586A MX2007007586A (en) 2004-12-21 2005-12-21 Compositions of influenza viral proteins and methods of use thereof.
US11/820,148 US20090162400A1 (en) 2004-12-21 2007-06-18 Compositions of influenza viral proteins and methods of use thereof

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US63825404P 2004-12-21 2004-12-21
US63835004P 2004-12-21 2004-12-21
US60/638,254 2004-12-21
US60/638,350 2004-12-21
US64506705P 2005-01-19 2005-01-19
US60/645,067 2005-01-19
US65320705P 2005-02-15 2005-02-15
US60/653,207 2005-02-15
US66687805P 2005-03-31 2005-03-31
US60/666,878 2005-03-31
US68207705P 2005-05-18 2005-05-18
US60/682,077 2005-05-18
US74120205P 2005-11-30 2005-11-30
US60/741,202 2005-11-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/714,873 Continuation-In-Part US8420102B2 (en) 2004-12-21 2007-03-06 Compositions that include hemagglutinin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/820,148 Continuation-In-Part US20090162400A1 (en) 2004-12-21 2007-06-18 Compositions of influenza viral proteins and methods of use thereof

Publications (2)

Publication Number Publication Date
WO2006069262A2 WO2006069262A2 (en) 2006-06-29
WO2006069262A3 true WO2006069262A3 (en) 2007-02-01

Family

ID=36272492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/046662 WO2006069262A2 (en) 2004-12-21 2005-12-21 Compositions of influenza viral proteins and methods of use thereof

Country Status (9)

Country Link
EP (1) EP1831259A2 (en)
JP (1) JP2008524261A (en)
AU (2) AU2005319141B8 (en)
BR (1) BRPI0519705A2 (en)
CA (1) CA2593746A1 (en)
MX (1) MX2007007586A (en)
NZ (1) NZ556004A (en)
SG (1) SG160424A1 (en)
WO (1) WO2006069262A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY157941A (en) 2005-01-19 2016-08-15 Vaxinnate Corp Compositions of pathogen-associated molecular patterns and methods of use
ES2534332T3 (en) 2006-03-07 2015-04-21 Vaxinnate Corporation Compositions that include hemagglutinin, preparation methods and methods of use thereof
EP2012829A4 (en) * 2006-04-24 2010-04-21 Protelix Inc Method for producing viral vaccine and therapeutic peptide antigens
CN101522210B (en) * 2006-09-18 2017-03-22 阿肯色大学评议会 Compositions and methods for enhancing immune responses
EP1925318A1 (en) * 2006-11-20 2008-05-28 Paul-Ehrlich-Institut Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu
US8778847B2 (en) * 2007-06-13 2014-07-15 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Immunogenic peptides of influenza virus
HUE025149T2 (en) 2007-08-02 2016-01-28 Biondvax Pharmaceuticals Ltd Multimeric multiepitope influenza vaccines
GB0720250D0 (en) * 2007-10-17 2007-11-28 Univ Edinburgh Immunogenic compositions containing escherichia coli h7 flagella and methods of use thereof
EP2223934B1 (en) * 2007-11-14 2012-10-03 Institute Of Microbiology, Chinese Academy Of Sciences Polypeptides for inhibiting influenza virus infection
WO2009128950A2 (en) 2008-04-18 2009-10-22 Vaxinnate Corporation Deletion mutants of flagellin and methods of use
WO2010115229A1 (en) 2009-04-09 2010-10-14 The University Of Melbourne Immunogenic composition and uses thereof
MX348663B (en) * 2009-09-08 2017-05-26 Inst Tecnologico Estudios Superiores Monterrey Recombinant proteins expressed in escherichia coli as active ingredients in vaccines against influenza a h1n1 outbreak 2009 and process for producing the same.
SG182305A1 (en) * 2010-01-06 2012-08-30 Vaxinnate Corp Methods and compositions for providing protective immunity in the elderly
UA110024C2 (en) 2010-01-21 2015-11-10 VACCINE VECTOR AND METHOD OF IMMUNE IMPROVEMENT
EP2552490A4 (en) * 2010-03-26 2013-12-18 Emergent Product Dev Gaithersburg Inc Ectodomains of influenza matrix 2 protein, expression system, and uses thereof
GB201009273D0 (en) * 2010-06-03 2010-07-21 Glaxosmithkline Biolog Sa Novel vaccine
EP3520814A1 (en) * 2010-09-22 2019-08-07 Ena Therapeutics Pty Ltd Immunostimulating composition
WO2012114323A1 (en) 2011-02-22 2012-08-30 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
US8932598B2 (en) 2012-08-28 2015-01-13 Vaxinnate Corporation Fusion proteins and methods of use
WO2014070848A1 (en) 2012-11-05 2014-05-08 Georgia State University Research Foundation Universal influenza vaccine based on heterologous multiple m2e proteins
RU2571944C1 (en) * 2014-10-17 2015-12-27 Общество с ограниченной ответственностью "НТфарма" Broad-spectrum m2 protein ectodomain avian influenza type a vaccine
US20220388950A1 (en) 2019-06-26 2022-12-08 Axelia Oncology Pty Ltd Novel molecules
AU2022338350A1 (en) * 2021-09-02 2024-02-29 Ena Respiratory Pty Ltd Formulation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014956A1 (en) * 2002-08-12 2004-02-19 The Council Of The Queensland Institute Of Medical Research Novel immunogenic lipopeptides comprising t-helper and b-cell epitopes
WO2004080403A2 (en) * 2003-03-07 2004-09-23 Merck & Co. Inc. Influenza virus vaccine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014956A1 (en) * 2002-08-12 2004-02-19 The Council Of The Queensland Institute Of Medical Research Novel immunogenic lipopeptides comprising t-helper and b-cell epitopes
WO2004080403A2 (en) * 2003-03-07 2004-09-23 Merck & Co. Inc. Influenza virus vaccine

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
APPLEQUIST STEVEN E ET AL: "Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin", JOURNAL OF IMMUNOLOGY, vol. 175, no. 6, September 2005 (2005-09-01), pages 3882 - 3891, XP002397612, ISSN: 0022-1767 *
ARNON R ET AL: "Peptide-based synthetic recombinant vaccines with anti-viral efficacy", BIOLOGICALS, ACADEMIC PRESS LTD., LONDON, GB, vol. 29, no. 3-4, September 2001 (2001-09-01), pages 237 - 242, XP002371258, ISSN: 1045-1056 *
BEN-YEDIDIA T ET AL: "INTRANASAL ADMINISTRATION OF PEPTIDE VACCINE PROTECTS HUMAN/MOUSE RADIATION CHIMERA FROM INFLUENZA INFECTION", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 11, no. 7, 1999, pages 1043 - 1051, XP000914818, ISSN: 0953-8178 *
FAN J ET AL: "Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 22, no. 23-24, 13 August 2004 (2004-08-13), pages 2993 - 3003, XP004525579, ISSN: 0264-410X *
HEINEN P P ET AL: "Vaccination of pigs with a DNA construct expressing an influenza virus M2-nucleoprotein fusion protein exacerbates disease after challenge with influenza virus", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD, GB, vol. 83, August 2002 (2002-08-01), pages 1851 - 1859, XP002990584, ISSN: 0022-1317 *
MCSORLEY S J ET AL: "Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 169, no. 7, 1 October 2002 (2002-10-01), pages 3914 - 3919, XP002271611, ISSN: 0022-1767 *
ZENG WEIGUANG ET AL: "Totally synthetic lipid-containing polyoxime peptide constructs are potent immunogens", VACCINE, vol. 18, no. 11-12, January 2000 (2000-01-01), pages 1031 - 1039, XP002382251, ISSN: 0264-410X *

Also Published As

Publication number Publication date
WO2006069262A2 (en) 2006-06-29
NZ556004A (en) 2010-05-28
AU2005319141B2 (en) 2010-02-18
BRPI0519705A2 (en) 2009-03-10
JP2008524261A (en) 2008-07-10
SG160424A1 (en) 2010-04-29
EP1831259A2 (en) 2007-09-12
AU2010200048A1 (en) 2010-01-28
MX2007007586A (en) 2007-12-10
CA2593746A1 (en) 2006-06-29
AU2005319141B8 (en) 2010-03-18
AU2005319141A1 (en) 2006-06-29

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