WO2006067063A3 - Screening methods for identification of modulators of cytokine class i - Google Patents

Screening methods for identification of modulators of cytokine class i Download PDF

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Publication number
WO2006067063A3
WO2006067063A3 PCT/EP2005/056694 EP2005056694W WO2006067063A3 WO 2006067063 A3 WO2006067063 A3 WO 2006067063A3 EP 2005056694 W EP2005056694 W EP 2005056694W WO 2006067063 A3 WO2006067063 A3 WO 2006067063A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
identification
cytokine class
cytokine
screening methods
Prior art date
Application number
PCT/EP2005/056694
Other languages
French (fr)
Other versions
WO2006067063A2 (en
Inventor
Vendela Parrow
Lars Olof Bergquist
Catrine Dreifeldt
Christine Flodin
Original Assignee
Biovitrum Ab
Vendela Parrow
Lars Olof Bergquist
Catrine Dreifeldt
Christine Flodin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum Ab, Vendela Parrow, Lars Olof Bergquist, Catrine Dreifeldt, Christine Flodin filed Critical Biovitrum Ab
Publication of WO2006067063A2 publication Critical patent/WO2006067063A2/en
Publication of WO2006067063A3 publication Critical patent/WO2006067063A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to methods for the identification of modulators of cytokine class I receptors by determining whether a compound that binds to a cytokine class I receptor at a site different from the binding site of the naturally-occurring cytokine ligand is effective at modulating the amount of the cytokine class I receptor on the surface of the cell.
PCT/EP2005/056694 2004-12-23 2005-12-12 Screening methods for identification of modulators of cytokine class i WO2006067063A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63869404P 2004-12-23 2004-12-23
US60/638,694 2004-12-23
SE0500078 2005-01-11
SE0500078-1 2005-01-11

Publications (2)

Publication Number Publication Date
WO2006067063A2 WO2006067063A2 (en) 2006-06-29
WO2006067063A3 true WO2006067063A3 (en) 2007-01-25

Family

ID=35929723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/056694 WO2006067063A2 (en) 2004-12-23 2005-12-12 Screening methods for identification of modulators of cytokine class i

Country Status (1)

Country Link
WO (1) WO2006067063A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005001478A1 (en) * 2003-06-30 2005-01-06 Biovitrum Ab Methods for identifying agents, which regulate cytokines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005001478A1 (en) * 2003-06-30 2005-01-06 Biovitrum Ab Methods for identifying agents, which regulate cytokines

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GOVERS, R., ET AL: "Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor", THE EMBO JOURNAL, vol. 18, no. 1, 1999, pages 28 - 36, XP002112904 *
LANDSMAN TANYA, WAXMAN DAVID J.: "Role of CIS in growth hormone receptor internalization and degradation", FASEB JOURNAL, vol. 18, no. 8, 14 May 2004 (2004-05-14), pages C273, XP009063003 *
LOBIE, P.E., ET AL: "Nuclear Translocation and Anchorage of the Growth Hormone Receptor", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 50, 1994, pages 31735 - 31746, XP002371335 *
SAITO Y., ET AL: "Ligand-induced internalization and phosphorylation-dependent degradation of growth hormone receptor in human IM-9 cells", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 106, 1996, pages 67 - 74, XP002371334 *
STROUS, G.J. AND VAN KERKHOF, P.: "The ubiquitin-proteasome pathway and the regulation of growth hormone receptor availability", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 197, 2002, pages 143 - 151, XP002371357 *

Also Published As

Publication number Publication date
WO2006067063A2 (en) 2006-06-29

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