WO2006064530A3 - Analogues de la dermorphine a activite analgesique - Google Patents

Analogues de la dermorphine a activite analgesique Download PDF

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Publication number
WO2006064530A3
WO2006064530A3 PCT/IT2005/000733 IT2005000733W WO2006064530A3 WO 2006064530 A3 WO2006064530 A3 WO 2006064530A3 IT 2005000733 W IT2005000733 W IT 2005000733W WO 2006064530 A3 WO2006064530 A3 WO 2006064530A3
Authority
WO
WIPO (PCT)
Prior art keywords
dermorphin
analgesic activity
aminoacid
fact
analogs
Prior art date
Application number
PCT/IT2005/000733
Other languages
English (en)
Other versions
WO2006064530A2 (fr
Inventor
Pietro Melchiorri
Lucia Negri
Raniero Rocchi
Luigi Ciocca
Original Assignee
Biogen S R L
Pietro Melchiorri
Lucia Negri
Raniero Rocchi
Luigi Ciocca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen S R L, Pietro Melchiorri, Lucia Negri, Raniero Rocchi, Luigi Ciocca filed Critical Biogen S R L
Priority to EP05823581A priority Critical patent/EP1831244A2/fr
Publication of WO2006064530A2 publication Critical patent/WO2006064530A2/fr
Publication of WO2006064530A3 publication Critical patent/WO2006064530A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des nouveaux analogues heptapeptides opioïdes de la dermorphine, qui se caractérisent en ce que, comme la dermorphine, ils conservent un reste de tyrosine en position 1 et un Dα-aminoacide, de préférence D-Ala, en position 2, et en ce qu'en position 7, ils possèdent l'aminoacide de basicité maximum, à savoir l'arginine. Le peptide préféré de l'invention, l'Arg7-dermorphine, appelé arginorphine, possède une activité analgésique puissante. Cette activité se produit largement au niveau du nocicepteur à opioïde périphérique, sans les effets secondaires centraux graves typiques des opiacés.
PCT/IT2005/000733 2004-12-15 2005-12-14 Analogues de la dermorphine a activite analgesique WO2006064530A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05823581A EP1831244A2 (fr) 2004-12-15 2005-12-14 Analogues de la dermorphine a activite analgesique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2004A000607 2004-12-15
ITRM20040607 ITRM20040607A1 (it) 2004-12-15 2004-12-15 Analoghi della dermorfina ad attivita' analgesica.

Publications (2)

Publication Number Publication Date
WO2006064530A2 WO2006064530A2 (fr) 2006-06-22
WO2006064530A3 true WO2006064530A3 (fr) 2007-02-08

Family

ID=36358951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2005/000733 WO2006064530A2 (fr) 2004-12-15 2005-12-14 Analogues de la dermorphine a activite analgesique

Country Status (3)

Country Link
EP (1) EP1831244A2 (fr)
IT (1) ITRM20040607A1 (fr)
WO (1) WO2006064530A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012158964A2 (fr) 2011-05-18 2012-11-22 Eumederis Pharmaceuticals, Inc. Substances pharmaceutiques peptidiques améliorées servant à lutter contre l'ostéoporose
CA3134906A1 (fr) 2011-05-18 2012-11-22 Mederis Diabetes, Llc Substances pharmaceutiques peptidiques ameliorees pour la resistance a l'insuline
EP3653649A1 (fr) 2012-11-20 2020-05-20 Mederis Diabetes, LLC Produits pharmaceutiques peptidiques améliorés pour la résistance à l'insuline
DK2922877T3 (da) 2012-11-20 2019-01-02 Eumederis Pharmaceuticals Inc Forbedrede peptidlægemidler
AU2015266854B2 (en) 2014-05-28 2020-03-26 Mederis Diabetes, Llc Improved peptide pharmaceuticals for insulin resistance
CA3086918A1 (fr) 2018-01-03 2019-07-11 Mederis Diabetes, Llc Composes pharmaceutiques peptidiques ameliores utilises pour le traitement d'une steatohepatite non alcoolique et d'autres troubles
PL439243A1 (pl) * 2021-10-18 2023-04-24 Instytut Medycyny Doświadczalnej I Klinicznej Im. Mirosława Mossakowskiego Polskiej Akademii Nauk Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEGRI, LUCIA ET AL: "Dermorphin-related peptides from the skin of Phyllomedusa bicolor and their amidated analogs activate two .mu. opioid receptor subtypes that modulate antinociception and catalepsy in the rat", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 89(15), 7203-7 CODEN: PNASA6; ISSN: 0027-8424, 1992, XP002382460 *

Also Published As

Publication number Publication date
ITRM20040607A1 (it) 2005-03-15
EP1831244A2 (fr) 2007-09-12
WO2006064530A2 (fr) 2006-06-22

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