WO2006063285A3 - Methods for identifying risk of breast cancer or prostate cancer and treatments thereof - Google Patents

Methods for identifying risk of breast cancer or prostate cancer and treatments thereof Download PDF

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Publication number
WO2006063285A3
WO2006063285A3 PCT/US2005/044718 US2005044718W WO2006063285A3 WO 2006063285 A3 WO2006063285 A3 WO 2006063285A3 US 2005044718 W US2005044718 W US 2005044718W WO 2006063285 A3 WO2006063285 A3 WO 2006063285A3
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WO
WIPO (PCT)
Prior art keywords
methods
breast cancer
cancer
prostate cancer
treatments
Prior art date
Application number
PCT/US2005/044718
Other languages
French (fr)
Other versions
WO2006063285A2 (en
Inventor
Richard B Roth
Matthew R Nelson
Stefan Kammerer
Andreas Braun
Rikard H Reneland
Carolyn R Hoyal-Wrightson
Mikhail F Denissenko
Caridad Rosette
Original Assignee
Sequenom Inc
Richard B Roth
Matthew R Nelson
Stefan Kammerer
Andreas Braun
Rikard H Reneland
Carolyn R Hoyal-Wrightson
Mikhail F Denissenko
Caridad Rosette
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequenom Inc, Richard B Roth, Matthew R Nelson, Stefan Kammerer, Andreas Braun, Rikard H Reneland, Carolyn R Hoyal-Wrightson, Mikhail F Denissenko, Caridad Rosette filed Critical Sequenom Inc
Publication of WO2006063285A2 publication Critical patent/WO2006063285A2/en
Publication of WO2006063285A3 publication Critical patent/WO2006063285A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Provided herein are methods for identifying a subject at risk of breast cancer or prostate cancer, methods for providing a prognosis to a subject at risk of breast cancer or suffering from breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer or prostate cancer, and therapeutic methods for treating breast cancer or prostate cancer in a subject. These embodiments are based upon and analysis of polymorphic variations in nucleotide sequences within the human genome.
PCT/US2005/044718 2004-12-10 2005-12-09 Methods for identifying risk of breast cancer or prostate cancer and treatments thereof WO2006063285A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63483904P 2004-12-10 2004-12-10
US60/634,839 2004-12-10
US68325705P 2005-05-20 2005-05-20
US60/683,257 2005-05-20

Publications (2)

Publication Number Publication Date
WO2006063285A2 WO2006063285A2 (en) 2006-06-15
WO2006063285A3 true WO2006063285A3 (en) 2008-01-17

Family

ID=36578637

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/044718 WO2006063285A2 (en) 2004-12-10 2005-12-09 Methods for identifying risk of breast cancer or prostate cancer and treatments thereof

Country Status (1)

Country Link
WO (1) WO2006063285A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102317470A (en) * 2007-02-07 2012-01-11 解码遗传学私营有限责任公司 Genetic variants contributing to risk of prostate cancer
AU2009269542A1 (en) 2008-07-07 2010-01-14 Decode Genetics Ehf Genetic variants for breast cancer risk assessment

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COX ET AL.: "A common coding variant in CASP8 is associated with breast cancer risk", NATURE GENETICS, vol. 39, no. 3, March 2007 (2007-03-01), pages 352 - 358 *
COX ET AL.: "Polymorphisms in the ICAm gene locus are not associated with breast cancer risk", CANCER EPIDEMIOL. BIOMARKERS PREV., vol. 15, no. 1, January 2006 (2006-01-01), pages 178 - 179 *
DATABASE NCBI [online] accession no. SNP Database accession no. (rs1056538) *
KAMMERER ET AL.: "Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus", CANCER RESEARCH, vol. 64, December 2004 (2004-12-01), pages 8906 - 8910 *

Also Published As

Publication number Publication date
WO2006063285A2 (en) 2006-06-15

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