WO2006063085A3 - Process for purifying target compounds from plant sources using ceramic filtration - Google Patents

Process for purifying target compounds from plant sources using ceramic filtration Download PDF

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Publication number
WO2006063085A3
WO2006063085A3 PCT/US2005/044325 US2005044325W WO2006063085A3 WO 2006063085 A3 WO2006063085 A3 WO 2006063085A3 US 2005044325 W US2005044325 W US 2005044325W WO 2006063085 A3 WO2006063085 A3 WO 2006063085A3
Authority
WO
WIPO (PCT)
Prior art keywords
target compounds
plant sources
ceramic filtration
purifying target
plant
Prior art date
Application number
PCT/US2005/044325
Other languages
French (fr)
Other versions
WO2006063085A2 (en
Inventor
Stephen J Garger
Barry Bratcher
Fakhrieh Vojdani
Original Assignee
Large Scale Biology Corp
Stephen J Garger
Barry Bratcher
Fakhrieh Vojdani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Large Scale Biology Corp, Stephen J Garger, Barry Bratcher, Fakhrieh Vojdani filed Critical Large Scale Biology Corp
Publication of WO2006063085A2 publication Critical patent/WO2006063085A2/en
Publication of WO2006063085A3 publication Critical patent/WO2006063085A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis

Abstract

The present invention describes a method for isolating a target compound from a plant, the method comprising obtaining a plant extract, passing such plant extract through a ceramic filter to obtain a permeate, and purifying the target compound from such permeate. This method, among other things, allows ultrafiltration of crude plant extracts, such as green juice homogenates.
PCT/US2005/044325 2004-12-10 2005-12-10 Process for purifying target compounds from plant sources using ceramic filtration WO2006063085A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63521404P 2004-12-10 2004-12-10
US60/635,214 2004-12-10
US11/249,685 US20060218667A1 (en) 2004-10-12 2005-10-12 Plant-produced recombinant aprotinin and aprotinin variants
US11/249,685 2005-10-12

Publications (2)

Publication Number Publication Date
WO2006063085A2 WO2006063085A2 (en) 2006-06-15
WO2006063085A3 true WO2006063085A3 (en) 2009-04-02

Family

ID=36578540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/044325 WO2006063085A2 (en) 2004-12-10 2005-12-10 Process for purifying target compounds from plant sources using ceramic filtration

Country Status (2)

Country Link
US (1) US20060218667A1 (en)
WO (1) WO2006063085A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100447530B1 (en) * 2001-08-14 2004-09-08 한국과학기술원 A Method for Extracellular Production of Target Proteins Employing OmpF in E. coli

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000048703A1 (en) * 1999-02-22 2000-08-24 Henry Kopf Purification of biological substances

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
US5032573A (en) * 1987-03-23 1991-07-16 Bayer Aktiengesellschaft Homologs of aprotinin produced from a recombinant host, process, expression vector and recombinant host therefor and pharmaceutical use thereof
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
DK225488D0 (en) * 1988-04-26 1988-04-26 Novo Industri As POLYPEPTIDE
US5231010A (en) * 1989-09-13 1993-07-27 Bayer Aktiengesellschaft Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
DE3930522A1 (en) * 1989-09-13 1991-03-21 Bayer Ag RECOMBINANT APROTININ VARIANTS - GENETIC METHOD FOR MICROBIAL PRODUCTION OF HOMOGENEOUS APROTININ VARIANTS, AND THE THERAPEUTIC APPLICATION THEREOF
US5258302A (en) * 1990-07-03 1993-11-02 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA for expression of aprotinin in methylotrophic yeast cells
DE4417353A1 (en) * 1994-05-18 1996-01-25 Bayer Ag Process for the preparation of recombinant aprotinin and recombinant aprotinin variants with the natural N-terminal sequence
DE19629982A1 (en) * 1996-07-25 1998-01-29 Bayer Ag Aprotinin variants with improved properties

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000048703A1 (en) * 1999-02-22 2000-08-24 Henry Kopf Purification of biological substances

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GIDDING, G.: "Transgenic plants as protein factoeris", CURRENT OPINION IN BIOTECHNOLOGY, vol. 12, pages 450 - 454 *

Also Published As

Publication number Publication date
WO2006063085A2 (en) 2006-06-15
US20060218667A1 (en) 2006-09-28

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