WO2006062973A3 - Use of organic compounds - Google Patents

Use of organic compounds Download PDF

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Publication number
WO2006062973A3
WO2006062973A3 PCT/US2005/044119 US2005044119W WO2006062973A3 WO 2006062973 A3 WO2006062973 A3 WO 2006062973A3 US 2005044119 W US2005044119 W US 2005044119W WO 2006062973 A3 WO2006062973 A3 WO 2006062973A3
Authority
WO
WIPO (PCT)
Prior art keywords
organic compounds
iron
defesin
polypeptides
medicament
Prior art date
Application number
PCT/US2005/044119
Other languages
French (fr)
Other versions
WO2006062973A2 (en
Inventor
Ruben Papoian
Andreas Scherer
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Ruben Papoian
Andreas Scherer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Ruben Papoian, Andreas Scherer filed Critical Novartis Ag
Priority to JP2007545565A priority Critical patent/JP2008523068A/en
Priority to EP05853129A priority patent/EP1824506A2/en
Publication of WO2006062973A2 publication Critical patent/WO2006062973A2/en
Publication of WO2006062973A3 publication Critical patent/WO2006062973A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Abstract

The invention relates to DEFESIN 5 polypeptides for the manufacture of a medicament for use in the treatment of a disease or condition associated with iron imbalance or iron transport.
PCT/US2005/044119 2004-12-08 2005-12-07 Use of organic compounds WO2006062973A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2007545565A JP2008523068A (en) 2004-12-08 2005-12-07 Use of organic compounds
EP05853129A EP1824506A2 (en) 2004-12-08 2005-12-07 Use of organic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63434904P 2004-12-08 2004-12-08
US60/634,349 2004-12-08

Publications (2)

Publication Number Publication Date
WO2006062973A2 WO2006062973A2 (en) 2006-06-15
WO2006062973A3 true WO2006062973A3 (en) 2007-01-04

Family

ID=36405976

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/044119 WO2006062973A2 (en) 2004-12-08 2005-12-07 Use of organic compounds

Country Status (3)

Country Link
EP (1) EP1824506A2 (en)
JP (1) JP2008523068A (en)
WO (1) WO2006062973A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641497A (en) * 1992-05-22 1997-06-24 Children's Hospital Of Philadelphia Gastrointestinal defensins, cDNA sequences and method for the production and use thereof
WO2003025583A2 (en) * 2001-09-14 2003-03-27 F. Hoffmann-La Roche Ag Differential diagnosis of disorders of iron metabolism
WO2003070176A2 (en) * 2002-02-19 2003-08-28 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Modified defensins and their use
WO2003101394A2 (en) * 2002-05-31 2003-12-11 Ciphergen Biosystems, Inc. Defensins: use as antiviral agents
WO2004003195A1 (en) * 2002-06-28 2004-01-08 The Government Of The United States Of America,As Represented By The Secretary Of The Department Of Health And Human Services Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641497A (en) * 1992-05-22 1997-06-24 Children's Hospital Of Philadelphia Gastrointestinal defensins, cDNA sequences and method for the production and use thereof
WO2003025583A2 (en) * 2001-09-14 2003-03-27 F. Hoffmann-La Roche Ag Differential diagnosis of disorders of iron metabolism
WO2003070176A2 (en) * 2002-02-19 2003-08-28 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Modified defensins and their use
WO2003101394A2 (en) * 2002-05-31 2003-12-11 Ciphergen Biosystems, Inc. Defensins: use as antiviral agents
WO2004003195A1 (en) * 2002-06-28 2004-01-08 The Government Of The United States Of America,As Represented By The Secretary Of The Department Of Health And Human Services Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PIETRANGELO ANTONELLO ET AL: "Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disorders.", NATURE CLINICAL PRACTICE. GASTROENTEROLOGY & HEPATOLOGY. NOV 2004, vol. 1, no. 1, November 2004 (2004-11-01), pages 39 - 45, XP009077362, ISSN: 1743-4378 *
SELSTED M E ET AL: "ENTERIC DEFENSINS: ANTIBIOTIC PEPTIDE COMPONENTS OF INTESTINAL HOSTDEFENSE", 1 August 1992, JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, NEW YORK, US, US, PAGE(S) 929-936, ISSN: 0021-9525, XP000613234 *
YAMAMOTO K ET AL: "Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, AMSTERDAM, NL, vol. 1588, no. 3, 12 December 2002 (2002-12-12), pages 195 - 202, XP004389110, ISSN: 0925-4439 *

Also Published As

Publication number Publication date
EP1824506A2 (en) 2007-08-29
JP2008523068A (en) 2008-07-03
WO2006062973A2 (en) 2006-06-15

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