WO2006062240A1 - 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators - Google Patents

3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators Download PDF

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WO2006062240A1
WO2006062240A1 PCT/JP2005/022907 JP2005022907W WO2006062240A1 WO 2006062240 A1 WO2006062240 A1 WO 2006062240A1 JP 2005022907 W JP2005022907 W JP 2005022907W WO 2006062240 A1 WO2006062240 A1 WO 2006062240A1
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groups
group
alkyl
halogen atoms
aryl
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PCT/JP2005/022907
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French (fr)
Inventor
Katsuaki Miyaji
Yukihiro Shigeta
Satoshi Nakano
Shunsuke Iwamoto
Yutaka Hirokawa
Hirofumi Ota
Kazufumi Yanagihara
Shingo Owada
Norihisa Ishiwata
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Nissan Chemical Industries, Ltd.
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Priority to CN2005800415992A priority Critical patent/CN101072766B/en
Priority to NZ555466A priority patent/NZ555466A/en
Priority to CA2588979A priority patent/CA2588979C/en
Priority to AU2005312585A priority patent/AU2005312585B2/en
Priority to EP05816744A priority patent/EP1819692A1/en
Priority to MX2007006819A priority patent/MX2007006819A/en
Application filed by Nissan Chemical Industries, Ltd. filed Critical Nissan Chemical Industries, Ltd.
Priority to US11/721,252 priority patent/US8552031B2/en
Priority to JP2007526867A priority patent/JP4985402B2/en
Publication of WO2006062240A1 publication Critical patent/WO2006062240A1/en
Priority to NO20072753A priority patent/NO20072753L/en
Priority to IL183647A priority patent/IL183647A/en
Priority to HK08105161.4A priority patent/HK1115125A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Definitions

  • the present invention relates to preventive, therapeutic and improving agents having affinity for and io agonistic action on the thrombopoietin receptor for diseases against which activation of the thrombopoietin receptor is effective. Specifically, it relates to pharmaceutical compositions comprising compounds which increase platelets through stimulation of differentiation
  • Thrombopoietin is a cytokine consisting of 332 amino acids that increases platelet production by stimulating 25 differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes mediated by its receptor and therefore is promising as a drug for hematological disorders.
  • Recent reports that it stimulates differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells have raised expectations of therapeutic angiogenesis, anti- arteriosclerosis and prevention of cardiovascular events (for example, non-patent document 1, non-patent document 2 and non-patent document 3) .
  • Biologically active substances which have been known so far to regulate platelet production through the thrombopoietin receptor include, in addition to thrombopoietin itself, low molecular weight peptides having affinity for the thrombopoietin receptor (for example, patent document 1, patent document 2, patent document 3 and patent document 4) .
  • low molecular weight compounds having affinity for the thrombopoietin receptor have been reported (for example, patent document 5 to patent document 26) .
  • Patent document 24 Japanese Laid-open Patent Application filed by Japan Tabacco Inc.
  • Patent document 25 and 26 Japanese Laid-open Patent Applications filed by Nissan Chemical Industries, Ltd.
  • Patent document 5 JP-A-11-1477 Patent document 6 JP-A-11-152276 Patent document 7 WOOl/07423 Patent document 8 WO01/53267 Patent document 9 WO02/059099 Patent document 10 WO02/059100 Patent document 11 WO00/35446 Patent document 12 WOO0/66112 Patent document 13 WO01/34585 Patent document 14 WOOl/17349 Patent document 15 WOOl/39773 Patent document 16 WOO1/21180 Patent document 17 WO01/89457 Patent document 18 WO02/49413 Patent document 19 WO02/085343 Patent document 20 JP-A-2001-97948 Patent document 21 WO99/11262 Patent document 22 WO02/062775 Patent document 23 WO03/062233 Patent document 24 JP-A-2003-238565 Patent document 25 WO04/033433 Patent document 26 WO04/108683
  • Non-patent document 1 Microvasc. Res., 1999: 58, p.108-113
  • Thrombopoietin and low molecular weight peptides having affinity for the thrombopoietin receptor are likely to be easily degraded in the gastrointestinal tract and are usually difficult to orally administer.
  • thrombopoietin itself the appearance of anti- thrombopoietin antibodies have been reported.
  • low molecular weight compounds having excellent affinity for and agonistic action on the thrombopoietin receptor as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective have been demanded.
  • low molecular weight compounds which can serve as platelet increasing agents or increasing agents for other blood cells by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or low molecular weight compounds which can be used for therapeutic angiogenesis or as preventive and therapeutic agents for arteriosclerosis by stimulating endothelial cells and endothelial progenitor cells have been demanded.
  • the present inventors conducted extensive research to find low molecular weight compounds having affinity for and agonistic action on the thrombopoietin receptor, and as a result, found that the compounds of the present invention have high affinity and agonistic action which enable them to show potent platelet increasing action by stimulating differentiation and proliferation of megakaryocytic progenitor cells and megakaryocytes.
  • the present invention was accomplished on the basis of this discovery. Namely, the present invention relates to: 1.
  • A is a nitrogen atom or CR 4 (wherein R 4 is a hydrogen atom, a hydroxy1 group (the hydroxyl group may be substituted with a C 2 - ⁇ alkenyl group or a C 2 . 6 alkynyl group) , a thiol group (the thiol group may be substituted with a C 1 - I0 alkyl group, a C 2 - 6 alkenyl group, a C 2 .
  • the C 2 - 14 aryl groups and the C 2 _ 14 aryloxy groups may be substituted with one or more C 1 - S alkyl groups (the Ci_ 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) )
  • a C 2 - 14 aryl group (the C 2 -i 4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci- I0 alkyl groups (the Ci- I0 alkyl groups may be substituted with, one or more halogen atoms) , C 2 -s alkenyl groups, C 2 - 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci- I0 alkoxy groups, Ci- I0 alkylcarbonyl groups, Ci_i 0 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups,
  • 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C 2-14 aryl group (the C 2 . 14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_ 10 alkyl groups (the C 1 - J-0 alkyl groups may be substituted with one or more halogen atoms) , C 2-6 alkenyl groups, C 2 .
  • the C x - I0 alkoxy group, the Ci-io alkylcarbonyloxy group, the C x-10 alkoxycarbonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C x -I 0 alkoxy groups, Ci_i o alkylcarbonyl groups, C x - I0 alkylcarbonyloxy groups, Ci-i 0 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di-Ci-I 0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -i4 aryl groups and C 2 - X4 aryloxy groups (the C 2 _ X4 aryl groups and the C 2 - X4 aryloxy groups may be substitute
  • Ci- I0 alkyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci -10 alkoxy groups, Ci- I0 alkylcarbonyl groups, Ci- I0 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups, Ci- I0 alkylcarbonylamino groups, amino groups, mono- or di
  • L 1 is a bond, CR 10 R 11 (wherein each of R 10 and R 11 is independently a hydrogen atom or a C 1-6 alkyl group (the Ci- 6 alkyl group may be substituted with one or more halogen atoms) ) , an oxygen atom, a sulfur atom or NR 12 (wherein R 12 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci- I0 alkyl group, a C 2-6 alkenyl group, a C 2 _e alkynyl group, a Ci -I0 alkoxy group, a Ci -I0 alkylcarbonyloxy group, a Ci -I0 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-I0 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the Ci- I0 alkoxy group, the C 1-10 alkylcarbonyloxy group, the
  • 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C 2 - 14 aryl group (the C 2 - I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C 1 -I 0 alkyl groups (the C 1-10 alkyl groups may be substituted with one or more halogen atoms) , C 2-6 alkenyl groups, C 2 _ 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1-10 alkoxy groups, C 1-10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups, amino groups, mono- or di-C 1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2-14 aryl groups and C 2-14 aryl
  • R 2 is a hydrogen atom, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1-10 alkoxy groups, C 1-10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, C 1 I 10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups, amino groups, mono- or di-C 1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 - 14
  • L 2 is a bond, CR 34 R 35 (wherein each of R 34 and R 35 is independently a hydrogen atom or a C 1-6 alkyl group (the C 1-6 alkyl group may be substituted with one or more halogen atoms) ) , an oxygen atom, a sulfur atom or NR 16 (wherein R 16 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and
  • L 3 is a bond
  • CR 17 R 18 (wherein each of R 17 and R 18 is independently a hydrogen atom, a C 1 - J-0 alkyl group, a C 2 - 6 alkenyl group, a C 2 - 6 alkynyl group, a C 1 -O -0 alkoxy group, a Ci-io alkylcarbonyl group (the Ci_ 10 alkyl group, the C 2 - 6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1-10 alkoxy groups, C 1-10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups,
  • Y is an oxygen atom, a sulfur atom or NR 23 (wherein R 23 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci- 10 alkyl group, a C 2 . 5 alkenyl group, a C 2 - 6 alkynyl group, a Ci-10 alkoxy group, a Ci -10 alkylcarbonyloxy group, a Ci- I0 alkoxycarbonyl group, a Ci -I0 alkylcarbonyl group (the Ci- I0 alkyl group, the C 2 -6 alkenyl group, the C 2 - 6 alkynyl group, the Ci -I0 alkoxy group, the Ci_i 0 alkylcarbonyloxy group, the Ci- I0 alkoxycarbonyl group and the Ci- I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen
  • Ci- I0 alkoxy groups Ci-I 0 alkylcarbonyl groups, Ci- I0 alkylcarbonyloxy groups, Q L - IO alkoxycarbonyl groups, Ci- I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i 0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -i 4 aryl groups and C 2 -14 aryloxy groups) )
  • Ci- I0 alkoxy groups Ci-I 0 alkylcarbonyl groups, Ci- I0 alkylcarbonyloxy groups, Q L - IO alkoxycarbonyl groups, Ci- I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i 0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -i 4 aryl groups and C 2 -14 aryloxy groups) )
  • L 4 is a bond, CR 20 R 21 (wherein each of R 20 and R 21 is independently a hydrogen atom, a C 1 -I 0 alkyl group, a C 2 -6 alkenyl group, a C 2 - 6 alkynyl group, a C I - I Q alkoxy group, a Ci-io alkylcarbonyl group (the Ci_i 0 alkyl group, the C 2 . 6 alkenyl group, the C 2 .
  • the C ⁇ -i 0 alkoxy group and the Ci_i 0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C I - I Q alkoxy groups, Ci_i 0 alkylcarbonyl groups, C x - I0 alkylcarbonyloxy groups, C x - I0 alkoxycarbonyl groups, C 1 -I 0 alkylcarbonylamino groups, amino groups, mono- or di-Ci- I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 - 14 aryl groups and C 2 -i 4 aryloxy groups (the C 2 -I 4 aryl groups and the C 2 - I4 aryloxy groups may be substituted with one or more Ci_ 6 alkyl groups (the Ci- 6 alkyl groups may be substituted with one or more Ci_ 6 alky
  • R 3 is a methyl group (the methyl group may be optionally substituted with one or more substituents selected from the group consisting of C 1 -I 0 alkyl groups, C 2 _ 10 alkenyl groups, C 2-10 alkynyl groups, C 2 - S heterocyclic groups, C 1-10 alkoxy groups, C 1-10 thioalkyl groups, Ci- 10 alkylcarbonyl groups, mono- or di- C 1 - I0 alkylamino groups, Ci -10 alkylcarbonyloxy groups, C x _ 10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups (the Ci-io alkyl groups, the C 2 -I 0 alkenyl groups, the C 2 -io alkynyl groups, the C 2 -g heterocyclic groups, the C x - 10 alkoxy groups, the C 1 - K3 thioalkyl groups, the Ci- I0 alkyl
  • 3 alkyl group may be substituted with one or more halogen atoms) , m is 0, 1, 2 or 3, and W 4 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a Ci- I0 alkyl group, a C 2 .
  • the C 2 - I4 aryl groups and the C 2 - I4 aryloxy groups may be substituted with one or more Q L _ 6 alkyl groups (the Ci- 5 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) or a C 2 - I4 aryl group (the C 2 - I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i 0 alkyl groups (the Ci- I0 alkyl groups may be substituted with one or more halogen atoms) , C 2 -6 alkenyl groups, C 2 - 6 alkynyl groups, carboxyl group, nitro groups, cyano groups, halogen atoms, C 1 - X0 alkoxy groups,
  • the C ⁇ - 10 alkoxy group, the C 1 - X-0 alkylcarbonyloxy group, the C 1 - X0 alkoxycarbonyl group and the Ci_ 10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci- I0 alkoxy groups, C 1 - X0 alkylcarbonyl groups, C 1 - X0 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups, C 1 -I 0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -i 4 aryl groups and C 2 -14 aryloxy groups (the C 2 -I 4 aryl groups and the C 2 - I4 aryloxy groups may be substituted with one
  • heterocyclic group may be optionally substituted with one or more substituents selected from the group consisting of C 1 - I0 alkyl groups, C 2 - 10 alkenyl groups, C 2 - 10 alkynyl groups, C 2 -g heterocyclic groups, C 1 -Ho alkoxy groups, C 1 - H0 thioalkyl groups, C 1 -Io alkylcarbonyl groups, mono- or di-Ci- ⁇ o alkylamino groups, C 1 -H 0 alkylcarbonyloxy groups, C 1 - H0 alkoxycarbonyl groups, C 1 -H 0 alkylsulfonyl groups, C 1-10 alkylaminocarbonyl groups, C 1 -Ho alkylaminosulfonyl groups, C 1 - H o dialkylaminocarbonyl groups, C 1 -Ho alkylcarbonylamino groups (the C 1 -Ho alkyl groups, the C 2-1 O alkenyl groups
  • lo alkynyl groups, the C 2-9 heterocyclic groups, the C 1 -Ho alkoxy groups, the C 1 - H o thioalkyl groups, the C 1 - H o alkylcarbonyl groups, the mono- or di-C ⁇ - ⁇ o alkylamino groups, the C 1 -H 0 alkylcarbonyloxy groups, the C 1 -Ho alkoxycarbonyl groups, the C 1 -H 0 alkylsulfonyl groups, the C 1 -Ho alkylaminocarbonyl groups, the C 1 - H0 alkylaminosulfonyl groups, the C 1 -Ho dialkylaminocarbonyl groups and the C 1 -Ho alkylcarbonylamino groups may be optionally substituted with one or more C 2 - H4 aryl groups (the C 2 - H4 aryl groups may be optionally substituted with one or more substituents independently represented by -W 1 (CW 2 W 3 )
  • Ci-io alkoxy group a Ci-io alkoxy group
  • Ci-io alkylcarbonyl group the Ci_i 0 alkyl group, the C 2 _ 6 alkenyl group, the C 2 - 6 alkynyl group, the Ci -I0 alkoxy group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C x - I0 alkoxy groups, Ci- I0 alkylcarbonyl groups, Ci- I0 alkylcarbonyloxy groups, C x - I0 alkoxycarbonyl groups, Ci- I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i 0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 _i 4 aryl groups and C 2 - I4 aryloxy groups (the Ci
  • the C 1 - X0 alkoxy group, the C 1 - X0 alkylcarbonyloxy group, the C 1 - I0 alkoxycarbonyl group and the Ci- I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_ 10 alkoxy groups, Ci-io alkylcarbonyl groups, Ci_i 0 alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or CU-C 1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -14 aryl groups and C 2 -I 4 aryloxy groups (the C 2 - I4 aryl groups and the C 2-14 aryloxy groups may be substituted with one or more C 1-6 alkyl groups (the C
  • the C 2 . 14 aryl groups may be optionally substituted with one or more substituents independently represented by -W 1 (CW 2 W 3 ) m W 4 (wherein W 1 , W 2 , W 3 , W 4 and m are the same as defined above) ) or one or more substituents independently represented by -W 5 (CW 6 W 7 ) ml0 W 8 (wherein W 5 , W 6 , W 7 , W 8 and mlO are the same as defined above) ) , substituents independently represented by -W 9 (CW 10 W 11 J 11111 W 12 (wherein W 9 , W 10 , W 11 , W 12 and mil are the same as defined above) and C 2 -i4 aryl groups (the C 2 -i4 aryl groups may be optionally substituted with one or more substituents independently represented by -W 13 (CW 14 W 15 ) ml2 W 16 (wherein W 13 , W 14 , W 15 ,
  • R 3 is a methyl group (the methyl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I 0 alkyl groups, C 2 -io alkenyl groups, C 2- io alkynyl groups, C 2 - 9 heterocyclic groups, C 1 - 10 alkoxy groups, Ci- 10 thioalkyl groups, Ci_i 0 alkylcarbonyl groups, mono- or di-Ci_ 10 alkylamino groups, C 1 - I0 alkylcarbonyloxy groups, C ⁇ 10 alkoxycarbonyl groups, C 1 - I0 alkylcarbonylamino groups (the C 1 -I 0 alkyl groups, the C 2 -: LO alkenyl groups, the C 2 _ 10 alkynyl groups, the C 2 _ 9 heterocyclic groups, the Ci_i 0 alkoxy groups, the C ⁇ .
  • the C 2 - 14 aryl groups and the C 2 _ 14 aryloxy groups may be substituted with one or more C ⁇ - 6 alkyl groups (the C 1 ⁇ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C 2 - 14 aryl group, a C 2 - 14 aryloxy group (the C 2 .
  • C 14 aryl group and the C 2 - 14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C 1 - IL0 alkyl groups (the C 1 - X0 alkyl groups may be substituted with one or more halogen atoms) , C 2 - ⁇ alkenyl groups, C 2 - 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1 - X0 alkoxy groups, C 1 - IL0 alkylcarbonyl groups, C ⁇ - 10 alkylcarbonyloxy groups, C; L - 10 alkoxycarbonyl groups, C ⁇ .
  • substituents selected from the group consisting of C 1 - IL0 alkyl groups (the C 1 - X0 alkyl groups may be substituted with one or more halogen atoms) , C 2 - ⁇ alkenyl groups, C 2 - 6 alkynyl
  • Ci-I 0 alkoxycarbonyl group a Ci_i 0 alkoxycarbonyl group, a C 1 -I 0 alkylsulfonyl group, a Ci-I 0 alkylcarbonyl group
  • the Ci- I0 alkyl group the C 2 - 6 alkenyl group, the C 2 - 6 alkynyl group, the Ci-I 0 alkoxy group, the Ci- ⁇ o alkylcarbonyloxy group, the Ci- I0 alkoxycarbonyl group, the Ci- I0 alkylsulfonyl group and the Ci- I0 alkylcarbonyl group
  • R 33 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1 - I0 alkyl group, a C 2-6 alkenyl group, C 2 -6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups,
  • the Ci-io alkoxy group, the Ci- I0 alkylcarbonyloxy group, the Ci-io alkylcarbonylamino group and the mono- or di- C x - IO alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci- I0 alkoxy groups, Ci- I0 alkylcarbonyl groups, C x - I0 alkylcarbonyloxy groups, Ci_i 0 alkoxycarbonyl groups, Ci_i 0 alkylcarbonylamino groups, amino groups, mono- or di-Ci -I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 - I4 aryl groups and C 2 -i 4 aryloxy groups (the C 2 -14 aryl groups and the C 2 - I4 aryloxy groups (the C 2 -14 aryl groups and the C
  • the C 2 - I0 alkyl group, the C 2 - I0 alkenyl group, the C 2 - I0 alkynyl group and the C 2 - g heterocyclic group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I 0 alkyl groups, C 2 -I 0 alkenyl groups, C 2 -I 0 alkynyl groups, C 2 - 9 heterocyclic groups, Ci_i 0 alkoxy groups, C 1 -I 0 thioalkyl groups, Ci.
  • L 4 is CR 20 R 21 (wherein each of R 20 and R 21 is independently a hydrogen atom, a Ci- I0 alkyl group, a C 2-6 alkenyl group, a C 2 -6 alkynyl group, a Ci_i 0 alkoxy group, a Ci_i 0 alkylcarbonyl group (the C 1-10 alkyl group, the C 2 -6 alkenyl group, the C 2 - 6 alkynyl group, the C 1-10 alkoxy group and the C 1-10 alkylcarbonyl group may be optionally .substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1-10 alkoxy groups, Ci -10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, Ci -10 alkoxycarbonyl groups, Ci -10 alkylcarbonylamino groups, amino groups, mono-
  • Ci- 10 alkoxy groups Ci- I0 alkylcarbonyl groups, C x -I 0 alkylcarbonyloxy groups, C x - I0 alkoxycarbonyl groups, Ci-I 0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i 0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -i 4 aryl groups and C 2 -i 4 aryloxy groups (the C 2 -I 4 aryl groups and the C 2 _i 4 aryloxy groups may be substituted with one or more Ci- 6 alkyl groups (the Ci_ 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) ) , and R 3 is a Ci-I 0 alkyl groups (the Ci_ 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)
  • the Ci-I 0 alkoxy group, the Ci_i 0 thioalkyl group, the Ci- I0 alkylcarbonyl group, the mono- or di-Ci- I0 alkylamino group, the Ci-io alkylcarbonyloxy group, the Ci_ 10 alkoxycarbonyl group and the C 1 - I0 alkylcarbonylamino group may be optionally substituted with one or more substituents selected from the group consisting of C 1 -I 0 alkyl groups, C 2 - 10 alkenyl groups, C 2 - 10 alkynyl groups, C 2 - 9 heterocyclic groups, Ci-io alkoxy groups, Ci_i 0 thioalkyl groups, C 1 - I0 alkylcarbonyl groups, mono- or di- Ci-io alkylamino groups, C 1 - H0 alkylcarbonyloxy groups, C 1 ⁇ 0 alkoxycarbonyl groups, Ci_i 0
  • alkynyl groups, the C 2 _ 9 heterocyclic groups, the Ci-I 0 alkoxy groups, the C 1 - X0 thioalkyl groups, the Ci_io alkylcarbonyl groups, the mono- or di-Ci-i 0 alkylamino groups, the Ci-I 0 . alkylcarbonyloxy groups, the Ci_i 0 alkoxycarbonyl groups and the Ci- I0 alkylcarbonylamino groups may be optionally substituted with one or more C 2 - 14 aryl groups (the C 2 .
  • aryloxy groups may be substituted with one or more Ci_ 6 alkyl groups (the Ci_ 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C 2 - 14 aryl group, a C 2 - 14 aryloxy group (the C 2 - I4 aryl group and the C 2 -I 4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci- 10 alkyl groups (the C x - I0 alkyl groups may be substituted with one or more halogen atoms) , C 2 _ 6 alkenyl groups, C 2 - 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i 0 alkoxy groups, C x -I 0 alkylcarbonyl groups, C x - I0 alkylcarbonyloxy groups, C x
  • R 30 is independently a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a C x - xo alkyl group, a C 2 - 6 alkenyl group, a C 2 . 6 alkynyl group, a C x - X0 alkoxy group, a C 1 . xo alkylcarbonyloxy group, a C x _ xo alkoxycarbonyl group, a C x .
  • xo alkylsulfonyl group a C 1 -I 0 alkylcarbonyl group (the C x _ xo alkyl group, the C 2 _ 6 alkenyl group, the C 2 - 6 alkynyl group, the C x _ xo alkoxy group, the Ci-io alkylcarbonyloxy group, the C 1 - X0 alkoxycarbonyl group, the C 1 -I 0 alkylsulfonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or- more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, C 1 -I 0 alkylcarbonyl groups, C 1 -O -0 alkylcarbonyloxy groups, C ⁇ - 10 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino
  • 14 aryl groups may be optionally substituted with one or more substituents independently represented by -W 13 (CW 14 W 15 ) ml2 W 16 (wherein W 13 , W 14 , W 15 , W 16 and ml2 are the same as W 1 , W 2' , W 3 , W 4 and m, respectively, and W 1 , W 2 , W 3 , W 4 and m are the same as defined above) ) ) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • substituents independently represented by -W 13 (CW 14 W 15 ) ml2 W 16 (wherein W 13 , W 14 , W 15 , W 16 and ml2 are the same as W 1 , W 2' , W 3 , W 4 and m, respectively, and W 1 , W 2 , W 3 , W 4 and m are the same as defined above) )
  • A is a nitrogen atom
  • B is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • A is a nitrogen atom
  • B is NR 9 other than NH
  • R 9 is a hydrogen, atom, a hydroxyl group, a formyl group, a C 1 - I0 alkyl group, a C 2 - ⁇ alkenyl group, a C 2 -6 alkynyl group, a C 1 - X0 alkoxy group, a C 1 -I 0 alkylcarbonyloxy group, a C 1 - IL o alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1 -I 0 alkyl group, the C 2 - ⁇ alkenyl group, the C 2 - ⁇ alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituent
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl group or a C 2 _ 6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-I 0 alkyl group, a C 2 -6 alkenyl group, a C 2 - 6 alkynyl group or a C 1 - X0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2 - 6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci- I0 alkyl group, a C 2 - 6 alkenyl group, a C 2 - 6 alkynyl
  • X4 aryloxy groups (the C 2 - X4 aryl groups and the C 2 - I4 aryloxy groups may be substituted with one or more C X - 6 alkyl groups (the C x - 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C 2 -I 4 aryl group (the C 2 - I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C x .10 alkyl groups (the C x - xo alkyl groups may be substituted with one.
  • halogen atoms C 2 -6 alkenyl groups, C 2 . 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C x - I0 alkoxy groups, C x . xo alkylcarbonyl groups, C X - X0 alkylcarbonyloxy groups, C x - X0 alkoxycarbonyl groups, C x - X0 alkylcarbonylamino groups, amino groups, mono- or di-C X - X0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 .
  • a C 2 - X4 aryloxy group (the C 2 -i 4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C 1-10 alkyl groups (the C 1 - I0 alkyl groups may be substituted with one or more halogen atoms) , C 2 - 6 alkenyl groups, C 2 -6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1-10 alkoxy groups, C 1 - I10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups, amino groups, mono- or di-C 1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -i 4 aryl groups and C 2-14 aryloxy groups) or
  • Ci_i 0 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1 - I0 alkoxy groups, Ci- I0 alkylcarbonyl groups, Ci- I0 alkylcarbonyloxy groups, Ci_i 0 alkoxycarbonyl groups, Ci-
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C z - ⁇ alkenyl group or a C 2 _ 6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci- 10 alkyl group, a C 2 - ⁇ alkenyl group, a C 2 - 6 alkynyl group or a Ci-I 0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2 - 6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I 0 alkyl group, a C 2 - 6 alkenyl group, a C 2 _ 6 alkyny
  • C 14 aryl groups and the C 2 - X4 aryloxy groups may be substituted with one or more C x _ 6 alkyl groups (the C x - 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C 2 - 14 aryl group (the C 2 - I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C 1 - I0 alkyl groups (the Ci- I0 alkyl groups may be substituted with one or more halogen atoms) , C 2-6 alkenyl groups, C 2 - 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i 0 alkoxy groups, Ci-I 0 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, C I _ I Q alkoxycarbonyl groups, C 1-10
  • the C 2 - 9 heterocyclic group and the C 1- I 0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci- 10 alkoxy groups, Ci- I0 alkylcarbonyl groups, C 1 - X0 alkylcarbonyloxy groups, C !
  • aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I 0 alkyl groups (the C 1-10 alkyl groups may be substituted with one or more halogen atoms) , C 2 - 6 alkenyl groups, C 2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1-10 alkoxy groups, C 1-10 alkylcarbonyl groups, Ci_ lo alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups, amino groups, mono- or di-C 1-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2-14 aryl groups and C 2-14 aryloxy groups) or NR 6 R 7 (wherein each of R 6 and R 7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a
  • aryloxy groups may be substituted with one or more C 1 - S alkyl groups (the C 1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C 2 - I4 aryl group (the C 2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C ⁇ - 10 alkyl groups (the C 1-10 alkyl groups may be substituted with one or more halogen atoms) , C 2 - 6 alkenyl groups, C 2 .
  • the hydroxyl group may be substituted with a C 2 . 6 alkenyl group or a C 2 - 6 alkynyl group
  • a thiol group (the thiol group may be substituted with a Ci-io alkyl group, a C 2 - ⁇ alkenyl group, a C 2 - 6 alkynyl group or a Ci -10 alkylcarbonyl group)
  • an amino group (the amino group may be substituted with one or two C 2 - 6 alkenyl groups or one or two C 2 - 6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci_i 0 alkyl group, a C 2 - 6 alkenyl group, a C 2 - 6 alkynyl group, a Ci- lo alkylcarbonylamino group, a mono- or di-Ci -I0 alkylamino
  • R 5 is a hydroxyl group, a C ⁇ _i 0 alkyl group, a C 2 _ 6 alkenyl group, a C 2 _ 6 alkynyl group, a C 2 - 9 heterocyclic group, a Ci- I0 alkoxy group (the Ci-io alkyl group, the C 2 - 6 alkenyl group, the C 2 - 6 alkynyl group, the C 2 _ 9 heterocyclic group and the Ci_i 0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I 0 alkoxy groups, Ci -I0 alkylcarbonyl
  • 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C 2 . 14 aryl group (the C 2 - I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci- I0 alkyl groups (the Ci- I0 alkyl groups may be substituted with one or more halogen atoms) , C 2 - 6 alkenyl groups, C 2 _ s alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I 0 alkoxy groups, C 1 - I0 alkylcarbonyl groups, Ci- I0 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups, C X - I0 alkylcarbonylamino groups, amino groups, mono- or di-C x -I 0 alkylamino groups, hydroxyl groups, protected
  • a C 2 -I 4 aryloxy group (the C 2 - I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C x - I0 alkyl groups (the C X - X0 alkyl groups may be substituted with one or more halogen atoms) , C 2 - 6 alkenyl groups, C 2 - 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I 0 alkoxy groups, C 1 - I0 alkylcarbonyl groups, C 1 - I0 alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups, amino groups, mono- or di-C 1 - 0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -i 4
  • the C 2 - 14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-io alkyl groups (the C 1 -I 0 alkyl groups may be substituted with one or more halogen atoms), C 2 - 6 alkenyl groups, C 2 .
  • the Ci_i 0 alkoxy group, the Ci_i 0 alkylcarbonyloxy group, the Ci_io alkoxycarbonyl group and the C X - I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i 0 alkoxy groups, C 1-10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups, amino groups, mono- or di-C 1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 - 14 aryl groups and C 2 ⁇ 14 aryloxy groups (the C 2 -i4 aryl groups and the C 2-14 aryloxy groups may be substituted with one or more C 1-6 alkyl groups (the C 1-6 alkyl groups
  • L 3 is NR 19 (wherein R 19 is a hydrogen atom, a hydroxyl group, a formyl group, .a Ci-I 0 alkyl group, a C 2 .
  • L 3 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-io alkyl group, a C 2 -6 alkenyl group, a C 2 -6 alkynyl group, a Ci- I0 alkoxy group, a Ci_ 10 alkylcarbonyloxy group, a Ci-io alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the C 1 - I0 alkyl group, the C 2 - ⁇ alkenyl group, the C 2 -e alkynyl group, the C x - I0 alkoxy group, the Ci-I 0 alkylcarbonyloxy group, the
  • L 3 is the same as defined in 13, and L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C ⁇ - 10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C ⁇ .
  • R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C ⁇ - 10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C ⁇ .
  • lo alkylcarbonyl group (the C 1 - XO alkyl group, the C 2- 6 alkenyl group, the C 2 -6 alkynyl group, the C 1-10 alkoxy group, the C ⁇ - 10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of .carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1 - 10 alkoxy groups, C 1 - 10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups, amino groups, mono- or di-C 1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2-14 aryl groups and C 2-14 aryloxy groups (the C 2-14 aryl groups and the C 2 -
  • R 3 is a C 2-9 heterocyclic group (the C 2 - 9 heterocyclic group may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups, tetrazole groups, Ci- 10 alkoxycarbonyl groups, Ci-io alkoxy groups, Ci_i 0 thioalkyl groups, Ci_i 0 alkylcarbonyl groups, C 1 - I0 alkylcarbonyloxy groups, Ci-io alkylcarbonylamino groups and mono- or di- C 1-10 alkylamino groups) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • substituents selected from the group consisting of hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbam
  • R 3 is a C 2-9 heterocyclic group (the C 2 -g heterocyclic group is substituted with a substituent selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a sulfamoyl group, a tetrazole group and a Ci- I0 alkoxycarbonyl group and with a substituent selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a sulfamoyl group, a tetrazole group, a Ci- I0 alkoxycarbonyl group, a nitro group, a cyano group, a halogen atom, a Ci- I0 alky
  • R 3 is a Ci_i o alkyl group or a C 2 - I0 alkenyl group (the Ci-io alkyl group and the C 2 -io alkenyl group may be optionally substituted with one or more substituents selected from the group consisting of Ci- I0 alkyl groups, C 2 - I0 alkenyl groups, Ci-io alkoxy groups, Ci-io thioalkyl groups, Ci- I0 alkylcarbonyl groups, mono- or di-Ci-i 0 alkylamino groups, C x - I0 alkylcarbonyloxy groups, Ci_i 0 alkoxycarbonyl groups, Ci- I0 alkylcarbonylamino groups (the Ci-io alkyl groups, the C 2 -I 0 alkenyl groups, the Ci-io alkoxy groups, the C 1 -I 0 thioalkyl groups, the C 1-10 al
  • R 3 is a C 1-10 alkyl group or a C 2-10 alkenyl group
  • the Ci-io alkyl group and the C 2-10 alkenyl group may be optionally substituted with one or more substituents selected from the group consisting of C 1-10 alkyl groups, C 2 - 6 alkenyl groups, C 1-10 alkoxy groups, C 1-10 thioalkyl groups, C 1-10 alkylcarbonyl groups, mono- or di-C 1-10 alkylamino groups, C 1-10 alkylcarbonyloxyl groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups (the Ci-io alkyl groups, the C 2 -e alkenyl groups, the Ci_i 0 alkoxy groups, the Ci_i 0 thioalkyl groups, the C 1 -X 0 alkylcarbonyl groups, the mono- or di-Ci-I 0 alky
  • a preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective which contains the thrombopoietin receptor activator according to 27, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
  • the present invention provides pharmaceutical compositions comprising compounds which increase platelets through stimulation of differentiation and proliferation of hematopoietic stem cells , megakaryocytic progenitor cells and megakaryocytes or compounds for therapeut ic angiogenesis or with anti -arteriosclerosis action that stimulate dif ferentiation and prol iferation of vascular endothelial cells and endothel ial progenitor cells .
  • Fig . 1 shows the proliferation of UT7/EPO-mpl cells when stimulated by the compound of the present invention (Synthetic Example 4 ) .
  • Fig . 2 shows the proliferation of UT7/EPO cells when stimulated by the compound of the present invention ( Synthetic Example 4 ) . .
  • n denotes normal
  • i denotes iso
  • s denotes secondary
  • t denotes tertiary
  • c denotes cyclo
  • o denotes ortho
  • m denotes meta
  • p denotes para
  • Ph denotes phenyl
  • Py denotes pyridyl
  • Naphthyl denotes naphthyl
  • Me denotes methyl
  • Et denotes ethyl
  • Pr denotes propyl
  • Bu denotes butyl
  • Ac denotes acetyl .
  • a halogen atom a fluorine atom, a chlorine atom, a bromine atom or an iodine atom may be mentioned.
  • a C ⁇ - 3 alkyl group may be linear, branched or a C 3 cycloalkyl group, and methyl, ethyl, n-propyl, i-propyl and c-propyl and the like may be mentioned.
  • a C 1S alkyl group may be linear, branched or a C 3-5 cycloalkyl group, and in addition to those mentioned above, n-butyl, i-butyl, s-butyl, t-butyl, c-butyl, 1- methyl-c-propyl, 2-methyl-c-propyl, n-pentyl, 1-methyl-n- butyl, 2-methyl-n-butyl, 3-methyl-n-butyl, 1, 1-dimethyl- n-propyl, 1, 2-dimethyl-n-propyl, 2, 2-dimethyl-n-propyl, 1-ethyl-n-propyl, c-pentyl, 1-methyl-c-butyl, 2-methyl-c- butyl, 3-methyl-c-butyl, 1, 2-dimethyl-c-propyl, 2,3- dimethyl-c-propyl, 1-ethyl-c-propyl, 2-ethyl-c-
  • Ci-io alkyl group may be linear, branched or a C 3 -I 0 cycloalkyl group, and in addition to those mentioned above, 1-methyl-l-ethyl-n-pentyl, 1-heptyl, 2-heptyl, 1- ethyl-1, 2-dimethyl-n-propyl, l-ethyl-2, 2-dimethyl-n- propyl, 1-octyl, 3-octyl, 4-methyl-3-n-heptyl, 6-methyl- 2-n-heptyl, 2-propyl-1-n-heptyl, 2,4,4-trimethyl-l-n- pentyl, 1-nonyl, 2-nonyl, 2, 6-dimethyl-4-n-heptyl, 3- ethyl-2, 2-dimethyl-3-n-pentyl, 3,5, 5-trimethyl-l-n-hexyl, 1-decyl, 2-decyl, 4-decyl,
  • a C 2 - I0 alkyl group may be linear, branched or a C 3 - I0 cycloalkyl group, and those mentioned above as Ci-io alkyl groups except for a methyl group may be mentioned.
  • a C 2-6 alkynyl group ethynyl, 1-propynyl, 2- propynyl, 1-butynyl, 2-butynyl, 3-butynyl, l-methyl-2- propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3- butynyl, 3-methyl-1-butynyl, 1, 1-dimethyl-2-propynyl, 2- ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4- hex
  • a C 2 - I o alkynyl group may be linear or branched, and in addition to those mentioned above, 1-methyl-n-hexynyl, 1, 2-dimethyl-n-hexynyl, 1-ethyl-n-hexynyl, 1-n-heptynyl, 2-n-heptynyl, 3-n-heptynyl, 4-n-heptynyl, 1-n-octynyl, 2- n-octynyl, 3-n-octynyl and the like may be mentioned.
  • a C 2 - 6 alkenyl group may be linear, branched or a C 3 - 6 cycloalkenyl group, and ethenyl, 1-propenyl, 2-propenyl, 1-methyl-1-ethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2- methyl-1-propenyl, 2-methyl-2-propenyl, 1-ethylethenyl, 1-methyl-1-propenyl, 1-methyl-2-propenyl, 1-pentenyl, 2- pentenyl, 3-pentenyl, 4-pentenyl, 1-n-propylethenyl, 1- methyl-1-butenyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 2-ethyl-2-propenyl, 2-methyl-1-butenyl, 2-methyl-2- butenyl, 2-methyl-3-butenyl, 3-methyl-1-butenyl, 3- methyl-2-butenyl, 3-methyl-2-but
  • a C 2 - I o alkenyl group may be linear, branched or a C 3 - io cycloalkenyl group, and in addition to those mentioned above, 1-methyl-n-hexenyl, 1, 2-dimethyl-n-hexenyl, 1- ethyl-n-hexenyl, 1-n-heptenyl, 2-n-heptenyl, 3-n- heptenyl, 4-n-heptenyl, 1-n-octenyl, 2-n-octenyl, 3-n- octenyl, 1-methyl-c-hexenyl, 1, 2-dimethyl-c-hexenyl, 1- ethyl-c-hexenyl, 1-c-heptenyl, 2-c-heptenyl, 3-c- heptenyl, 4-c-heptenyl, 1-c-octenyl, 2-c-octenyl, 3-c- octen
  • a C 2 - 9 hetercyclic group may be a heteromonocyclic or fused heterobicyclic " group consisting of at least one atom optionally selected from nitrogen atoms, oxygen atoms and sulfur atoms and from 2 to 9 carbon atoms, and specifically, the following structures may be mentioned.
  • -* « -a -Q -Q -Q
  • a C 2 - I4 aryl group may be a C 6 _i 4 aryl group containing no hetero atoms as ring constituting atoms or a C 2 - 9 aromatic heterocyclic group, and a C 2 -g aromatic heterocyclic group may be a 5 to 7-membered C 2 - 6 heteromonocyclic group or 8 to 10-membered C 5-9 fused heterobicyclic group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.
  • a phenyl group As a C 6 - I4 aryl group containing no hetero atoms, a phenyl group, a 1-indenyl group, a 2-indenyl group, a 3- indenyl group, a 4-indenyl group, a 5-indenyl group, a 6- indenyl group, a 7-indenyl group, an ⁇ -naphthyl group, a ⁇ -naphthyl group, a 1-tetrahydronaphthyl group, a 2- tetrahydronaphthyl group, a 5-tetrahydronaphthyl group, a 6-tetrahydronaphthyl group, an o-biphenylyl group, a m- biphenylyl group, a p-biphenylyl group, a 1-anthryl group, a 2-anthryl group, a 9-anthryl group,
  • a 5 to 7-membered C 2 _ 6 heteromonocyclic group may be a 2-thienyl group, a 3-thienyl group, a 2-furyl group, a 3- furyl group, a 2-pyranyl group, a 3-pyranyl group, a 4- pyranyl group, a 1-pyrrolyl group, a 2-pyrrolyl group, a 3-pyrrolyl group, a 1-imidazolyl group, a 2-imidazolyl group, a 4-imidazolyl group, a 1-pyrazolyl group, a 3- pyrazolyl group, a 4-pyrazolyl group, a 2-thiazolyl group, a 4-thiazolyl group, a 5-thiazolyl group, a 3- isothiazolyl group, a 4-isothiazolyl group, a 5- isothiazolyl group, a 2-oxazolyl group, a 4-oxazolyl group, a 5-oxazolyl group,
  • a 8 to 10-membered C 5 - 9 fused heterocyclic group may be a 2-benzofuranyl group, a 3-benzofuranyl group, a 4- benzofuranyl group, a 5-benzofuranyl group, a 6- benzofuranyl group, a 7-benzofuranyl group, a 1- isobenzofuranyl group, a 4-isobenzofuranyl group, a 5- isobenzofuranyl group, a 2-benzothienyl group, a 3- benzothienyl group, a 4-benzothienyl group, a 5- benzothienyl group, a 6-benzothienyl group, a 7- benzothienyl group, a 1-isobenzothienyl group, a 4- isobenzothienyl group, a 5-isobenzothienyl group, a 2- chromenyl group, a 3-chromenyl group, a 4-chromenyl group, a 5-chro
  • a C 2 -i 4 aryloxy group may be a C 6 -i 4 aryloxy group containing no hetero atoms as ring constituting atoms or a C 2 - 9 aromatic heterocyclic oxy group, and a C 2 - 9 aromatic heterocyclic oxy group may be a 5 to 7-membered C 2 - 6 heteromonocyclic oxy group or 8 to 10-membered C 5 - 9 fused heterobicyclic oxy group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.
  • a C 6 .i 4 aryloxy group containing no hetero atoms a phenyloxy group, a 1-indenyloxy group, a 2-indenyloxy group, a 3-indenyloxy group, a 4-indenyloxy group, a 5- indenyloxy group, a 6-indenyloxy group, a 7-indenyloxy group, an ⁇ -naphthyloxy group, a ⁇ -naphthyloxy group, a 1-tetrahydronaphthyloxy group, a 2-tetrahydronaphthyloxy group, a 5-tetrahydronaphthyloxy group, a 6- tetrahydronaphthyloxy group, an o-biphenylyloxy group, a m-biphenylyloxy group, a p-biphenylyloxy group, a 1- anthryloxy group, a 2-anth
  • a 5 to 7-membered C 2 - ⁇ heteromonocyclic oxy group may be a 2-thienyloxy group, a 3-thienyloxy group, a 2- furyloxy group, a 3-furyloxy group, a 2-pyranyloxy group, a 3-pyranyloxy group, a 4-pyranyloxy group, a 1- pyrrolyloxy group, a 2-pyrrolyloxy group, a 3-pyrrolyloxy group, a 1-imidazolyloxy group, a 2-i ⁇ nidazolyloxy group, a 4-imidazolyloxy group, a 1-pyrazolyloxy group, a 3- pyrazolyloxy group, a 4-pyrazolyloxy group, a 2- thiazolyloxy group, a 4-thiazolyloxy group, a 5- thiazolyloxy group, a 3-isothiazolyloxy group, a 4- isothiazolyloxy group, a 5-isothiazolyloxy group,
  • a 8 to 10-membered C 5-9 fused heterobicyclic oxy group may be a 2-benzofuranyloxy group, a 3- benzofuranyloxy group, a 4-benzofuranyloxy group, a 5- benzofuranyloxy group, a 6-benzofuranyloxy group, a 7- benzofuranyloxy group, a 1-isobenzofuranyloxy group, a 4- isobenzofuranyloxy group, a 5-isobenzofuranyloxy group, a 2-benzothienyloxy group, a 3-benzothienyloxy group, a 4- benzothienyloxy group, a 5-benzothienyloxy group, a 6- benzothienyloxy group, a 7-benzothienyloxy group, a 1- isobenzothienyloxy group, a 4-isobenzothienyloxy group, a 5-isobenzothienyloxy group, a 2-chromenyloxy group,
  • Ci- 6 alkylcarbonyl group may linear, branched or a C 3 - 6 cycloalkylcarbonyl group, and be methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, i-propylcarbonyl, c- propylcarbonyl, n-butylcarbonyl, i-butylcarbonyl, s- butylcarbonyl, t-butylcarbonyl, c-butylcarbonyl, 1- methyl-c-propylcarbonyl, 2-methyl-c-propylcarbonyl, n- pentylcarbonyl, 1-methyl-n-butylcarbonyl, 2-methyl ⁇ n ⁇ butylcarbonyl, 3-methyl-n-butylcarbonyl, 1, 1-dimethyl-n- propylcarbonyl, 1, 2-dimethyl-n-propylcarbonyl, 2,2- dimethyl-n-propylcarbonyl, 1-ethyl-
  • C 3 - 10 cycloalkylcarbonyl group and in addition to those mentioned above, 1-methyl-l-ethyl-n-pentylcarbonyl, 1- heptylcarbonyl, 2-heptylcarbonyl, 1-ethyl-1, 2-dimethyl-n- propylcarbonyl, 1-ethyl-2,2-dimethyl-n-propylcarbonyl, 1- octylcarbonyl, 3-octylcarbonyl, 4-methyl-3-n- heptylcarbonyl, 6-methyl-2-n-heptylcarbonyl, 2-propyl-1- n-heptylcarbonyl, 2,4, 4-trimethyl-l-n-pentylcarbonyl, 1- nonylcarbonyl, 2-nonylcarbonyl, 2, 6-dimethyl-4-n- heptylcarbonyl, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonyl, 3, 5, 5-trimethyl-l
  • Ci- 6 alkylaminosulfonyl group may be linear, branched or a C 3 - 6 cycloalkylaminosulfonyl group, and methylaminosulfonyl, ethylaminosulfonyl, n- propylaminosulfonyl, i-propylaminosulfonyl, c- propylaminosulfonyl, n-butylaminosulfonyl, i- butylaminosulfonyl, s-butylaminosulfonyl, t- butylaminosulfonyl, c-butylaminosulfonyl, 1-methyl-c- propylaminosulfonyl, 2-methyl-c-propylaminosulfonyl, n- pentylaminosulfonyl, 1-methyl-n-butylaminosulfonyl, 2- methyl-n-butylaminos
  • Ci-io alkylaminosulfonyl group may be linear, branched or a C 3 - I0 cycloalkylsulfonylamino group, and in addition to those mentioned above, 1-methyl-1-ethyl-n- pentylaminosulfonyl, 1-heptylaminosulfonyl, 2- heptylaminosulfonyl, 1-ethyl-1, 2-dimethyl-n- propylaminosulfonyl, l-ethyl-2, 2-dimethyl-n- propylaminosulfonyl, 1-octylaminosulfonyl, 3- octylaminosulfonyl, 4-methyl-3-n-heptylaminosulfonyl, 6- methyl-2-n-heptylaminosulfonyl, 2-propyl-1-n- heptylaminosulfonyl, 2,4,4-trimethyl-l-n
  • Ci- 6 alkylsulfonyl group may be linear, branched or a C 3 - 6 cycloalkylsulfonyl group, and methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, i-propylsulfonyl, c- propylsulfonyl, n-butylsulfonyl, i-butylsulfonyl, s- butylsulfonyl, t-butylsulfonyl, c-butylsulfonyl, 1- methyl-c-propylsulfonyl, 2-methyl-c-propylsulfonyl, n- pentylsulfonyl, 1-methyl-n-butylsulfonyl, 2-methyl-n-butylsulfonyl, 3-methyl.-n-butylsul
  • a C 1 - X0 alkylsulfonyl group may be linear, branched or a C 3 - 10 cycloalkylsulfonyl group, and in addition to those mentioned above, 1-methyl-l-ethyl-n-pentylsulfonyl, 1- heptylsulfonyl, 2-heptylsulfonyl, 1-ethyl-l,2-dimethyl-n- propylsulfonyl, l-ethyl-2,2-dimethyl-n-propylsulfonyl, 1- octylsulfonyl, 3-octylsulfonyl, 4-methyl-3-n- heptylsulfonyl, 6-methyl-2-n-heptylsulfonyl, 2-propyl-l- n-n-heptylsulfonyl, 2, 4,4-trimethyl-l-n-pentyl
  • Ci-io alkoxy group may be linear, branched or a C 3 - I0 cycloalkoxy group, and methoxy, ethoxy, n-propoxy, i- propoxy, c-propoxy, n-butoxy, i-butoxy, s-butoxy, t- butoxy, c-butoxy, 1-methyl-c-propoxy, 2-methyl-c-propoxy, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy, 3- methyl-n-butoxy, 1, 1-dimethyl-n-propoxy, 1,2-dimethyl-n- propoxy, 2,2-dimethyl-n-propoxy, 1-ethyl-n-propoxy, c- pentyloxy, 1-methyl-c-butoxy, 2-methyl-c-butoxy, 3- methyl-c-butoxy, 1, 2-dimethyl-c-propoxy, 2,3-dimethyl-c-propoxy, 1-ethyl-c-propoxy, 2-e
  • Ci-xo thioalkyl group may linear, branched or a C 3 -I 0 cyclothioalkyl group, and be methylthio, ethylthio, n- propylthio, i-propylthio, c-propylthio, n-butylthio, i- butylthio, s-butylthio, t-butylthio, c-butylthio, 1- methyl-c-propylthio, 2-methyl-c-propylthio, n-pentylthio, 1-methyl-n-butylthio, 2-methyl-n-butylthio, 3-methyl-n- butylthio, 1, 1-dimethyl-n-propylthio, 1,2-dimethyl-n- propylthio, 2, 2-dimethyl-n-propylthio, 1-ethyl-n- propylthio, c-pentylthi
  • a Ci- 6 alkoxycarbonyl group may be linear, branched or a C 3 -( S cycloalkoxycarbonyl group, and methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, c- propoxylcarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, s- butoxycarbonyl, t-butoxycarbonyl, c-butoxycarbonyl, 1- methyl-c-propoxycarbonyl, 2-methyl-c-propoxycarbonyl, n- pentyloxycarbonyl, 1-methyl-n-butoxycarbonyl, 2-methyl-n- butoxycarbonyl, 3-methyl-n-butoxycarbonyl, 1, 1-dimethyl- n-propoxycarbonyl, 1, 2-dimethyl-n-propoxycarbonyl, 2,2- dimethyl-n-propoxycarbonyl, 1-ethyl-n-propoxycarbonyl, c-
  • Ci-io alkoxycarbonyl group may be linear, branched or a C 3 - 10 cycloalkoxycarbonyl group, and in addition to those mentioned above, 1-methyl-l-ethyl-n- pentyloxycarbonyl, 1-heptyloxycarbonyl, 2- heptyloxycarbonyl, 1-ethyl-l,2-dimethyl-n- propyloxycarbonyl, l-ethyl-2,2-dimethyl-n- propyloxycarbonyl, 1-octyloxycarbonyl, 3- octyloxycarbonyl, 4-methyl-3-n-heptyloxycarbonyl, 6- methyl-2-n-heptyloxycarbonyl, 2-propyl-1-n- heptyloxycarbonyl, 2,4,4-trimethyl-l-n-pentyloxycarbonyl, 1-nonyloxycarbonyl, 2-nonyloxycarbonyl, 2, 6-dimethyl-4-n
  • Ci-io alkylcarbonyloxy group may be linear, branched or a C 3 - 10 cycloalkylcarbonyloxy group, and methylcarbonyloxy, ethylcarbonyloxy, n-propylcarbonyloxy, i-propylcarbonyloxy, c-propylcarbonyloxy, n- butylcarbonyloxy, i-butylcarbonyl ' oxy, s-butylcarbonyloxy, t-butylcarbonyloxy, c-butylcarbonyloxy, 1-methyl-c- propylcarbonyloxy, 2-methyl-c-propylcarbonyloxy, n- pentylcarbonyloxy, 1-methyl-n-butylcarbonyloxy, 2-methyl- n-butylcarbonyloxy, 3-methyl-n-butylcarbonyloxy, 1,1- dimethyl-n-propylcarbonyloxy, 1, 2-dimethyl-n- propylcarbon
  • Ci-io alkylcarbonylamino group may be linear, branched or a C 3 - 10 cycloalkylcarbonylamino group, and methylcarbonylamino, ethylcarbonylamino, n- propylcarbonylamino, i-propylcarbonylamino, c- propylcarbonylamino, n-butylcarbonylamino, i- butylcarbonylamino, s-butylcarbonylamino, t- butylcarbonylamino, c-butylcarbonylamino, 1-methyl-c- propylcarbonylamino, 2-methyl-c-propylcarbonylamino, n- pentylcarbonylamino, 1-methyl-n-butylcarbonylamino, 2- methyl-n-butylcarbonylamino, 3-methyl-n- butylcarbonylamino, 1, 1-dimethyl-n-propylcarbony
  • Ci-io alkylaminocarbonyl group may be a Ci-I 0 monoalkylaminocarbonyl group or a Ci-io dialkylaminocarbonyl group.
  • a C 1-10 monoalkylaminocarbonyl group may be linear, branched or a C 3 - 10 cycloalkylaminocarbonyl group, and methylaminocarbonyl, ethylaminocarbonyl, n- propylaminocarbonyl, i-propylaminocarbonyl, c- propylaminocarbonyl, n-butylaminocarbonyl, i- butylaminocarbonyl, s-butylaminocarbonyl, t- butylaminocarbonyl, c-butylaminocarbonyl, 1-methyl-c- propylaminocarbonyl, 2-methyl-c-propylaminocarbonyl, n- pentylaminocarbonyl, 1-methyl-n-butylaminocarbonyl, 2- methyl-n-butylaminocarbonyl, 3-methyl-n- butylaminocarbonyl, 1, 1-dimethyl-n-propyla
  • a C 1 - I0 dialkylaminocarbonyl group may be symmetric or asymmetric.
  • a symmetric C 1 - X0 dialkylaminocarbonyl group may be linear, branched or a C 3 - I0 cycloalkylaminocarbonyl group, and dimethylaminocarbonyl, diethylaminocarbonyl, di-n-propylaminocarbonyl, di-i-propylaminocarbonyl, di-c- propylaminocarbonyl, di-n-butylaminocarbonyl, di-i- butylaminocarbonyl, di-s-butylaminocarbonyl, di-t- butylaminocarbonyl, di-c-butylaminocarbonyl, di- (1- methyl-c-propyl) aminocarbonyl, di- (2-methyl-c- propyl) aminocarbonyl, di-n-pentylaminocarbonyl, di- (1- methyl
  • An asymmetric C 1- I 0 dialkylaminocarbonyl group may be linear, branched or a C 3 _ 10 cycloalkylaminocarbonyl group, and (methyl, ethyl) aminocarbonyl, (methyl, n- propyl) aminocarbonyl, (methyl, i-propyl) aminocarbonyl, (methyl, c-propyl) aminocarbonyl, (methyl, n- butyl) aminocarbonyl, (methyl, i-butyl) aminocarbonyl, (methyl, s-butyl) aminocarbonyl, (methyl, t- butyl) aminocarbonyl, (methyl, n-pentyl) aminocarbonyl, (methyl, c-pentyl) aminocarbonyl, (methyl, n- hexyl) aminocarbonyl, (methyl, c-hexyl) aminocarbonyl, (ethyl, n-propyl) aminocarbonyl, (ethyl
  • Ci-io monoalkylamino group may be linear, branched or a C 3 - 10 cycloalkylamino group, and methylamino, ethylamino, n-propylamino, i-propylamino, c-propylamino, n-butylamino, i-butylamino, s-butylamino, t-butylamino, c-butylamino, 1-methyl-c-propylamino, 2-methyl-c- propylamino, n-pentylamino, 1-methyl-n-butylamino, 2- methyl-n-butylamino, 3-methyl-n-butylamino, 1, 1-dimethyl- n-propylamino, 1, 2-dimethyl-n-propylamino, 2, 2-dimethyl- n-propylamino, 1-ethyl-n-propylamino, c-pentyla
  • a C 1 - I0 dialkylamino group may be symmetric or asymmetric.
  • a symmetric C 1 -I 0 dialkylamino group may be linear, branched or a C 3 . 10 cycloalkylamino group, and dimethylamino, diethylamino, di-n-propylamino, di-i- propylamino, di-c-propylamino, di-n-butylamino, di-i- butylamino, di-s-butylamino, di-t-butylamino, di-c- butylamino, di- (1-methyl-c-propyl) amino, di- (2-methyl-c- propyl) amino, di-n-pentylamino, di- (1-methyl-n- butyl) amino, di- (2-methyl-n-butyl) amino, di- (3-methyl-n- butyl) amino, di- (1, 1-dimethyl-n-propyl
  • An asymmetric C 1-10 dialkylamino group may be linear, branched or a C 3-10 cycloalkylamino group, and (methyl, ethyl) amino, (methyl, n-propyl) amino, (methyl, i- propyl) amino, (methyl, c-propyl) amino, (methyl, n- butyl) amino, (methyl, i-butyl) amino, (methyl, s- butyl) amino, (methyl, t-butyl) amino, (methyl, n- pentyl) amino, (methyl, c-pentyl) amino, (methyl, n- hexyl) amino, (methyl, c-hexyl) amino, (ethyl, n- propyl) amino, (ethyl, i-propyl) amino, (ethyl, c- propyl) amino, (ethyl, n-butyl) amino, (ethyl, i-
  • the protecting group in a protected hydroxyl group may be a Ci -4 alkoxymethyl group (such as MOM: methoxymethyl, MEM: 2-methoxyethoxymethyl, ethoxymethyl, n-propoxymethyl, i-propoxymethyl, n-butoxymethyl, iBM: isobutyloxyraethyl, BUM: t-butoxymethyl, POM: pivaloyloxymethyl, SEM: trimethylsilylethoxymethyl and the like, preferably a Ci_ 2 alkoxymethyl or the like) , an aryloxymethyl (such as BOM: benzyloxymethyl, PMBM: p- methoxybenzyloxymethyl, p-AOM: p-anisyloxymethyl and the like) , a C 1-4 alkylaminomethyl group (such as dimethylaminomethyl) , a substituted acetamidomethyl group (such as Acm: acetamidomethyl, Tacm: trimethyl
  • acyl group (such as formyl, acetyl, fluoroacetyl, difluoroacetyl, trifluoroacetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, propionyl, Pv: pivaloyl, tigloyl and the like) , an arylcarbonyl group (such as benzoyl, benzoylformyl, benzoylpropionyl, phenylpropionyl and the like) , a C x - 4 alkoxycarbonyl group (such as methoxycarbonyl, ethoxycarbonyl, n- propoxycarbonyl, i-propoxycarbonyl, n-butoxycarbonyl, i- butoxycarbonyl, BOC: t-butoxycarbonyl, AOC: t- amyloxycarbonyl, VOC: vinyloxycarbonyl, AOC: allyloxycarbony
  • substituent R 1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group) , furyl groups (a 2-furyl group and a 3- furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group) , quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4- quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6- isoquinolyl group,
  • Ci_i 0 alkyl group a halogen atom, a Ci-io alkyl group substituted with one or more halogen atoms, a Ci_i 0 alkoxy group substituted with one or more halogen atoms, a nitro group, an amino group, an amino group substituted with one or two Ci -I0 alkyl groups, an amino group substituted with a Ci_io alkylcarbonyl group, a thiol group substituted with a Ci-io alkyl group, a thiol group substituted with a Ci-io alkylcarbonyl group, a hydroxyl group, a C 1-6 alkoxy group, a Ci-io alkylcarbonyloxy group, a C 1 - I0 alkoxycarbonyl group and a Ci-io alkylcarbonyl group.
  • substituent R 1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group) , furyl groups (a 2-fury1 group and a 3-furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group) , quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4- quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl.
  • Substituents a methyl group, a t-butyl group, a trifluoromethyl group, a trifluoromethoxy group, a chlorine atom, a bromine atom, a fluorine atom, a methoxy group, a methylamino group, a dimethylamino group, a t- butyloxy group and a t-butylamino group.
  • substituents are a 3-methyl-phenyl group, a 4-methyl- phenyl group, a 3,4-dimethyl-phenyl group, a 3-t-butyl- phenyl group, a 4-t-butyl-phenyl group, a 3- trifluoromethyl-phenyl group, a 4-trifluoromethoxy-phenyl group, a 4-trifluoromethyl-phenyl group, a 3,4- ditrifluoromethyl-phenyl group, a 3-chloro-phenyl group, a 4-chloro-phenyl group, a 4-bromo-phenyl group, a 3- fluoro-phenyl group, a 4-fluoro-phenyl group, a 3,4- dichloro-phenyl group, a 4-methoxy-phenyl group, a 4- methylamino-phenyl group, a 3-methyl-thienyl group, a 4- methyl-thienyl
  • L 1 are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, N-Me, N-CHO, CHMe, CMe 2 , N-CH 2 Ph and the like, and particularly preferable examples are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, NMe and the like.
  • substituent R 2 are a hydrogen atom, a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a t-butyl group, and a phenyl group (the methyl group, the ethyl group, the n- propyl group, the i-propyl group, the t-butyl group and the phenyl group may be optionally substituted with an amino group, a monomethylamino group, a dimethylamino group, a monoethylamino group, a diethylamino group, a methoxy group, an ethoxy group, a methoxycarbonyl group, an ethoxycarbonyl group, a methylcarbonyloxy group, an ethylcarbonyloxy group, a methylcarbonylamino group or an ethylcarbonylamino group and the like) , and particularly preferable examples
  • L 2 are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, N-Me, N-CHO, CHMe, CMe 2 , N-CH 2 Ph and the like, and particularly preferable examples are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, NMe and the like.
  • L 3 are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, NH-OH, N-Me, N-CHO, CHMe, CMe 2 , N-CH 2 PH and the like, and particularly preferred examples are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, NMe and the like.
  • Y are an oxygen atom, a sulfur atom, NH, N-OH, N-CHO, N-Me, N-CH 2 Ph, N- OMe, N-OCH 2 Ph an the like, and particularly preferred examples are an oxygen atom, a sulfur atom, NH, N-OH and the like.
  • L 4 are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, N-Me, N-CHO, CHMe, CMe 2 , N-CH 2 Ph and the like, and particularly preferred examples are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, NMe and the like.
  • substituent R 3 are a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a s-butyl group, a t- butyl group, a c-propyl group, a c-butyl group, a c- pentyl group, a c-hexyl group, an ethynyl group, a 1- propynyl group, a 2-propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a l-methyl-2- butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3- butynyl group, a 3-methyl-1
  • Substituents a hydrogen atom, a hydroxyl group, an amino group, a halogen atom, a nitro group, a thiol group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a hydroxylcarbamoyl group, a cyanocarbamoyl group, a sulfamoyl group, a hydroxysulfamoyl group, a cyanosulfamoyl group, a tetrazole group, a phenyl group, a thienyl group, a pyridyl group, a furyl group, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H,
  • 10 alkyl group may be substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, the following aryl groups, the following heterocyclic groups and C 1-I0 alkylamino groups (the C 1-10 alkylamino groups may be substituted with one or more of the following aryl groups • or one or more of the heterocyclic groups) ) , a C 2-10 alkenyl group, a C 2 . 10 alkynyl group, a C 2 .
  • Aryl groups a phenyl group, thienyl groups (a 2- thienyl group and a 3-thienyl group) , furyl groups (a 2- furyl group and a 3-furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and 4- pyridyl group) , pyrimidinyl groups (a 2-pyrimidinyl group, a 4-pyrimidinyl group and a 5-pyrimidinyl group) , quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3- isoquino
  • Heterocyclic groups a 1,3,4-oxadiazole group, a 1, 3,4-thiadiazole group, a 1, 2,4-oxadiazole group, a 1, 2,4-thiadiazole group, a 1, 2, 5-oxadiazole group, a 1,2, 5-thiadiazole group, a 1,2-oxazole group and a 1,2- thiazole group.
  • substituent R 3 are a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a n-butyl group, a s- butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1- butynyl group, a 2-butynyl group, a 3-butynyl group, a 1- pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a 1-methyl-2-butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3-butynyl group, a 3-methyl-1
  • Substituent set A a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a hydroxycarbamoyl group, a cyanocarbamoyl group, a sulfamoyl group, a hydroxysulfamoyl group, a cyanosulfamoyl group, a tetrazole group, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H and an alkoxycarbonyl group.
  • Substituent set B a hydroxy1 group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a hydroxycarbamoyl group, a cyanocarbamoyl group, a sulfamoyl group, a nitro group, a cyano group, a halogen atom, a C 1 - I0 alkyl group, a Ci_ 10 alkyl group substituted with one or more fluorine atoms, a sulfamoyl group substituted with a Ci_i 0 alkyl group, a carbamoyl group substituted with a Ci-io alkyl group, a C 1 - io alkylcarbonylamino group and a Ci- 10 alkylaminocarbonyl group (the C 1-10 alkylcarbonylamino group and the C x -I 0 alkylamin
  • thrombopoietin receptor activator the preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective and the platelet increasing agent of the present invention are as follows. 1) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 2) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl or a C 2-6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-I 0 alkyl group, a C 2 -6 alkenyl group, a C 2 - 6 alkynyl group or a C 1 -I 0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2 - 6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2 .
  • R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alken
  • aryl group may be optionally substituted with one or more substituents selected from the group consisting of C 1-10 alkyl groups (the Ci_i 0 alkyl groups may be substituted with one or more halogen atoms) , C 2-6 alkenyl groups, C 2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci- 10 alkoxy groups, C 1-10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups, amino groups, mono- or CU-C 1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -i4 aryl groups and C 2-14 aryloxy groups) , a C 2-14 aryloxy group (the C 2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C 1-10 alkyl groups (
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2 _ 6 alkenyl or a C 2 _ 6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci -I0 alkyl group, a C 2 - 6 alkenyl group, a C 2 - 6 alkynyl group or a C x - I0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C 2 - ⁇ alkenyl groups or one or two C 2 - 6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a C 1 - I0 alkyl group, a C 2 - 6 alkenyl group, a C 2 _ 6
  • the C 2 - I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C 1 - X0 alkyl groups (the Ci- I0 alkyl groups may be substituted with one or more halogen atoms) , C 2 -e alkenyl groups, C 2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci- 10 alkoxy groups, Ci_ 10 alkylcarbonyl groups, Ci- 10 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups, Ci- I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci- 10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 _ 14 aryl groups and C 2 - I4 aryloxy groups) , a C 2 - I4 aryloxy group (the C 2 - I4 aryloxy group may
  • the Ci -I0 alkoxy group, the Ci_i 0 alkylcarbonyloxy group, the Ci -I0 alkoxycarbonyl group and the C x-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1-10 alkoxy groups, C 1- I 0 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylcarbonylamino groups, amino groups, mono- or di-C 1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 .
  • the C 2-14 aryl groups and the C 2-I4 aryloxy groups may be substituted with one or more Ci_ 6 alkyl groups (the Ci_ 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C 2 - 1 4 aryl group (the C 2 - 14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C 1 -I 0 alkyl groups (the Ci-I 0 alkyl groups may be substituted with one or more halogen atoms) , C 2 - ⁇ alkenyl groups, C 2 - 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci- 10 alkoxy groups, Ci_ 10 alkylcarbonyl groups, Ci- I0 alkylcarbonyloxy groups, Ci_ 10 alkoxycarbonyl groups
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2 - 6 alkenyl or a C 2 - 6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci- I0 alkyl group, a C 2 - 6 alkenyl group, a C 2 _ 6 alkynyl group or a Ci- I0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C 2 - 6 alkenyl groups or one or two C 2 - 6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci- I0 alkyl group, a C 2 -6 alkenyl group, a C 2 - ⁇ alkynyl group,
  • a C 2 - I4 aryloxy group (the C 2 - I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci -I0 alkyl groups (the Ci_i 0 alkyl groups may be substituted with one or more halogen atoms) , C 2 - 6 alkenyl groups, C 2 .
  • R 5 is a hydroxyl group, a Ci- 10 alkyl group, a C 2 - 6 alkenyl group, a C 2 - 6 alkynyl group, a Ci_i 0 alkoxy group (the Ci- I0 alkyl group, the C 2-6 alkenyl group, the C 2 - 6 alkynyl group and the C 1 - I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci- I0 alkoxy groups, Ci_i 0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci_io alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups,an amino groups, mono- or di- Ci_io alkylamino
  • the Ci- I0 alkoxy group, the Ci- I0 alkylcarbonyloxy group, the Ci-I 0 alkoxycarbonyl group and the Ci_i 0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i 0 alkoxy groups, Ci- I0 alkylcarbonyl groups, Ci- 10 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups, C 1 - I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 - I4 aryl groups and C 2 - I4 aryloxy groups (the C 2 - I4 aryl groups and the C 2 - I4 aryloxy groups may be substituted with one or more Ci_ 6 alkyl groups (the C 2 - I4
  • 10 alkyl groups may be substituted with one or more halogen atoms) , C 2 - 6 alkenyl groups, C 2 - 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i 0 alkoxy groups, C 1 - I0 alkylcarbonyl groups, C 1-I0 alkylcarbonyloxy groups, C ⁇ .
  • R 9 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-io alkyl group, a C 2 -6 alkenyl group, a C 2 - 6 alkynyl group, a C 1 -X 0 alkoxy group, a C 1 -I 0 alkylcarbonyloxy group, a C 1 - I0 alkoxycarbonyl group, a C 1 - HO alkylcarbon
  • A is CR 37 (wherein R 37 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl or a C 2 _ 6 alkynyl group) , a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2 - ⁇ alkynyl group or a C 1-10 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C 2-5 alkenyl groups or one or two C 2 - 6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2 - 6 alkynyl group
  • R 38 is a hydroxyl group, a C 1 - X0 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group (the C 1 .
  • the C 2-6 alkenyl group, the C 2-6 alkynyl group and the C 1 - O-0 alkoxy group may be substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups and cyano groups) , a C 2 - 14 aryl group or a C 2 - I4 aryloxy group (the C 2 - I4 aryl group and the C 2 - I4 aryloxy group may be substituted with one or more Ci- 6 alkyl groups (the Ci- 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • the terms in the respective substituents R 37 and R 38 are the same as those in the respective substituents R 1 to R 36 .
  • Ci- 6 alkyl groups may be substituted with one or more halogen atoms
  • C 2 - 6 alkenyl groups C 2 - 6 alkynyl groups, carboxyl groups, nitro groups, cyano groups and halogen atoms
  • tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof are the same as those in the respective substituents R 1 to R 36 .
  • L 3 is NR 19 (wherein R 19 is a hydrogen atom, a hydroxy1 group, a formyl group, a C 2 - I0 alkyl group, a C 2 - 6 alkenyl group, a C 2 -6 alkynyl group, a C 1-10 alkoxy group, a C 1 - I0 alkylcarbonyloxy group, a Ci- 10 alkoxycarbonyl group, a Ci- 10 alkylcarbonyl group (the C 1 - I0 alkyl group, the C 2 _ 6 alkenyl group, the C 2 _ e alkynyl group, the C 1-10 alkoxy group, the Ci- 10 alkylcarbonyloxy group, the C 1 - X0 alkoxycarbonyl group and the Ci- I0 alkylcarbony
  • the Ci_ 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C 2 - 14 aryl group (the C 2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C 3.
  • Ci- 10 alkyl groups (the Ci- 10 alkyl groups may be substituted with one or more halogen atoms) , C 2 -6 alkenyl groups, C 2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1 - I0 alkoxy groups, C 1-I0 alkylcarbonyl groups, C 1 - X0 alkylcarbonyloxy groups, C 1-10 alkoxycarbonyl groups, Ci- 10 alkylcarbonylamino groups, amino groups, mono- or di-Ci- 10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2-14 aryl groups and C 2-14 aryloxy groups)) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 2 is a hydrogen atom, a C 1 - I0 alkyl group, a C 2 _ 6 alkenyl group, a C 2 - 6 alkynyl group, a Ci-io alkoxy group
  • the Ci- I0 alkyl group, the C 2 -e alkenyl group, the C 2 - 6 alkynyl group and the Ci-io alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci -10 alkoxy groups, Ci- I0 alkylcarbonyl groups, C x - I0 alkylcarbonyloxy groups, Ci_i 0 alkoxycarbonyl groups, Ci_i 0 alkylcarbonylamino groups, amino groups, mono- or di-C x - I0 alkylamino groups, hydroxyl groups, protected
  • aryloxy group may be substituted with one or more Ci_ 6 alkyl groups (the C X - 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 2 is a hydrogen atom, a Ci -I0 alkyl group, a C 2-6 alkenyl group, a C 2 - 6 alkynyl group, a Ci_ 3 alkoxy group
  • the Ci-io alkyl group, the C 2 -e alkenyl group, the C 2 _ 6 alkynyl group and the Ci_ 3 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci_i 0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci-I 0 alkoxycarbonyl groups, Ci- I0 alkylcarbonylamino groups, amino groups, mono- or di-C 1 - I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, phenyl
  • 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , a phenyl group or a phenyloxy group (the phenyl group and the phenyloxy group may be substituted with one or more Ci- 6 alkyl groups (the Ci- 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 2 is a hydrogen atom, a Ci-io alkyl group, a C 2 - ⁇ alkenyl group or a C 2 . 6 alkynyl group (the C 1 - I0 alkyl group, the C 2 - 6 alkenyl group and the C 2 . 6 alkynyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci_i 0 alkylcarbonyl groups, Ci_ 10 alkylcarbonyloxy groups, C 1 .
  • Ci_ 6 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1 - I0 alkoxy groups, C 1-10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, Ci_i 0 alkoxycarbonyl groups, Ci_i 0 alkylcarbonylamino groups, amino groups, mono- or di-C 1 - X0 alkylamino groups, hydroxyl groups and protected hydroxyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1 - I0 alkoxy groups, C 1-10 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, Ci_i 0 alkoxycarbonyl groups, Ci_i 0 al
  • R 2 is a hydrogen atom or a C 3. - 3 alkyl group
  • the C 1-3 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, Ci_i 0 alkoxy groups, Ci- I0 alkylcarbonyl groups, Ci_i 0 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups, C 1 - I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups and protected hydroxyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof .
  • R 1 is a C 2 - 14 aryl group
  • the C 2 . 14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci-10 alkyl groups, C 2 -6 alkenyl groups, C 2 -6 alkynyl groups, C 1 -I 0 alkoxy groups, Ci_ 10 alkylcarbonyl groups, Ci- 10 alkoxycarbonyl groups, Ci- I0 alkylcarbonyloxy groups (the Ci_i 0 alkyl groups, the C 2 - 6 alkenyl groups, the C 2 - S alkynyl groups and the Ci_i 0 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups
  • aryl groups and the C 2 - I4 aryloxy groups may be substituted with one or more Ci_ 6 alkyl groups (the Ci_ 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) , C 2 - I4 aryl groups, C 2 - I4 aryloxy groups (the C 2 -I 4 aryl groups and the C 2 - I4 aryloxy groups may be substituted with one or more Ci- ⁇ alkyl groups (the Ci_ 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of formyl groups, Ci-io alkyl groups, C 2 - ⁇ alkenyl groups, C 2 - ⁇ alkynyl groups and Ci-io alkylcarbony
  • R 1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C 1 - I0 alkyl groups, C 2-6 alkenyl groups, C 2-6 alkynyl groups, Ci_i 0 alkoxy groups, Ci -10 alkylcarbonyl groups, C 1 -
  • R 1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci_i 0 alkyl groups, C 2 - 6 alkenyl groups, C 2 .
  • Ci- I0 alkylcarbonyl groups Ci- I0 alkoxycarbonyl groups, Ci- lo alkylcarbonyloxy groups (the Ci- I0 alkyl groups, the C 2 - 6 alkenyl groups, the C 2 - 6 alkynyl groups, the Ci- lo alkoxy groups, the Ci -10 alkylcarbonyl groups, the Ci_i 0 alkoxycarbonyl groups and the Ci-io alkylcarbonyloxy groups may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups and cyano groups) , C 2-I4 aryl groups, C 2 -i 4 aryloxy groups (the C 2 -I 4 aryl groups and the C 2 - I4 aryloxy groups may be substituted with one or more Ci- 6 alkyl groups (the Ci -6 alkyl groups may be substituted with one
  • Ci- I0 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, cyano groups, hydroxyl groups and protected hydroxyl groups) ) ) ) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci_i 0 alkyl groups, C 2 - ⁇ alkenyl groups, C 2 - ⁇ alkynyl groups, Ci-io alkoxy groups, Ci-io alkylcarbonyl groups, Ci-I 0 alkoxycarbonyl groups, Ci- I0 alkylcarbonyloxy groups (the Ci- I0 alkyl groups, the C 2 - 6 alkenyl groups, the C 2 -6 alkynyl groups, the C x - I0 alkoxy groups, the Ci- I0 alkylcarbonyl groups, the Ci- I0 alkoxycarbonyl groups and the Ci-
  • R 1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci-io alkyl groups, C 2-6 alkenyl groups, C 2-6 alkynyl groups, C 1 - X0 alkoxy groups, C 1 - X0 alkylcarbonyl groups, Ci- 10 alkoxycarbonyl groups, Ci- I0 alkylcarbonyloxy groups (the C 1 - I0 alkyl groups, the C 2 -6 alkenyl groups, the C 2 -6 alkynyl groups, the Ci-io alkoxy groups, the C 1 -I 0 alkylcarbonyl groups, the C 1 - I0 alkoxycarbonyl groups and the
  • aryl groups and the C 2-14 aryloxy groups may be substituted with one or more C 1 - S alkyl groups (the C 1-6 .alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of formyl groups, C 1-10 alkyl groups, C 2-6 alkenyl groups, C 2-6 alkynyl groups and C 1-10 alkylcarbonyl groups (the C 1-10 alkyl groups, the C 2-6 alkenyl groups, the C 2-6 alkynyl groups and the C 1 - I0 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, cyano groups, hydroxyl groups and protected hydroxyl groups))), tautomers
  • the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of
  • Heterocyclic groups a 1, 3,4-oxadiazole group, a 1, 3,4-thiadiazole group, a 1, 2, 4-oxadiazole group, a 1, 2,4-thiadiazole group, a 1, 2, 5-oxadiazole group, a 1, 2, 5-thiadiazole group, a 1,2-oxazole group, a 1,2- thiazole group, a 1,3-oxazole group, a 1,3-thiazole group, a pyrrole group, an imidazole group and a pyrazole group) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • L 4 is a bond
  • R 3 is a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a n-butyl group, a s- butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1- butynyl group, a 2-butynyl group, a 3-butynyl group, a 1- pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a 1-methyl-2-butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3
  • the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the
  • Ci-I 0 alkyl groups Ci-I 0 alkyl groups, C 2-I0 alkenyl groups, C 2-10 alkynyl groups, C 2 _ 9 heterocyclic groups, Ci-I 0 alkoxy groups, Ci_i 0 thioalkyl groups, Ci_i 0 alkylcarbonyl groups, mono- or di- Ci- I0 alkylamino groups, Ci- I0 alkylcarbonyloxy groups, Ci_i 0 alkoxycarbonyl groups and Ci-io alkylcarbonylamino groups (the Ci-io alkyl groups, the C 2 - I0 alkenyl groups, the C 2 -io alkynyl groups, the C 2 - 9 heterocyclic groups, the Ci-io alkoxy groups, the Ci- I0 thioalkyl groups, the Ci_i 0 alkylcarbonyl groups, the mono- or di-Ci_i 0 alkylamino groups, the Ci- I0 alkoxy groups
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulf amoyl groups, cyano sulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH, -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH, d_ 10 alkoxycarbonyl groups, Ci-io alkyl groups, C 1-10 alkylcarbonyl groups, C 1 - I0 alkylsulfonyl groups, C 1 - 0 alkyl groups
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH, -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH, C 1 -I 0 alkoxycarbonyl groups, Ci- I0 alkyl groups, C 2 - I0 alkenyl groups, C 2 - I0 alkynyl groups, C 2 - 9 heterocyclic groups, Ci
  • heterocyclic groups are optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH,
  • -OCH 2 OH -NHCH 2 OH, -CH 2 CH 2 OH, C 1-10 alkoxycarbonyl groups, methyl groups, ethyl groups, n-propyl groups, i-propyl groups, methylcarbonyl groups, ethylcarbonyl groups, n- propylcarbonyl groups, methylsulfonyl groups, ethylsulfonyl groups, n-propylsulfonyl groups, i- propylsulfonyl groups, methylaminosulfonyl groups, ethylaminosulfonyl groups, n-propylaminosulfonyl groups, i-propylaminosulfonyl groups, methylaminocarbonyl groups, ethylaminocarbonyl groups, n-propylaminocarbonyl groups, i-propylaminocarobnyl groups, c-propylaminoc
  • L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I 0 alkyl group, a C 2 - ⁇ alkenyl group, a C 2 - 6 alkynyl group, a Ci- I0 alkoxy group, a C 1-10 alkylcarbonyloxy group, a Ci -10 alkoxycarbonyl group, a C 1 - I0 alkylcarbonyl group (the Ci-I 0 alkyl group, the C 2 - ⁇ alkenyl group, the C 2 - ⁇ alkynyl group, the Ci_i 0 alkoxy group, the Ci_i 0 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups
  • 6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C 2 - I4 aryl group (the C 2 - 14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C 1 - I0 alkyl groups (the C 1-10 alkyl groups may be substituted with one or more halogen atoms) , C 2-6 alkenyl groups, C 2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Q L - IO alkoxy groups, Ci_i 0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci- 10 alkoxycarbonyl groups, Ci- 10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I 0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 _i 4 aryl groups
  • the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group,, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the 1-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxy
  • L 4 is NR 22
  • R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-io alkyl group, a C 2-6 alkenyl group, a C 2 - 6 alkynyl group, a Ci-io alkoxy group, a Ci-I 0 alkylcarbonyloxy group, a Ci -10 alkoxycarbonyl group, a Ci-iQ alkylcarbonyl group (the Ci-I 0 alkyl group, the C 2 -6 alkenyl group, the C 2 - 6 alkynyl group, the Ci- I0 alkoxy group, the Ci_ 10 alkylcarbonyloxy group, the C 1-I0 alkoxycarbonyl group and the C x - I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups,
  • Ci- I0 alkyl groups the Ci -6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)
  • C 2 - I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci- I0 alkyl groups (the Ci- 10 alkyl groups may be substituted with one or more halogen atoms) , C 2 ⁇ alkenyl groups, C 2 - ⁇ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1 - I0 alkoxy groups, C 1 -I 0 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, C 1 - I0 alkoxycarbonyl groups, Ci- 10 alkylcarbonylamino groups, amino groups, mono- or di-Ci- 10 alkylamino groups, hydroxyl groups, protected hydroxy
  • the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the
  • L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci -I0 alkyl group, a C 2 - 6 alkenyl group, a C 2 _ 6 alkynyl group, a Ci- I0 alkoxy group, a Ci- I0 alkylcarbonyloxy group, a Ci- I0 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci-io alkyl group, the C 2 - 6 alkenyl group, the C 2-6 alkynyl group, the Ci -I0 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups
  • L 4 is NR 22
  • R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1 - IL0 alkylcarbonyl group
  • the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2 -6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1-10 alkylcarbonyl group
  • C 1-6 alkyl groups (the C 1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C 2-14 aryl group (the C 2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C 1-10 alkyl groups (the C 1-10 alkyl groups may be substituted with one or more halogen atoms) , C 2-6 alkenyl groups, C 2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C 1-10 alkoxy groups, Ci_i 0 alkylcarbonyl groups, C 1-10 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups, C 1 - X0 alkylcarbonyl amino groups, amino groups, mono- or di-Ci_i 0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C 2 -i
  • L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1 - I0 alkyl group, a C 2-6 alkenyl group, a C 2 - 6 alkynyl group, a Ci-io alkoxy group, a Ci -I0 alkylcarbonyloxy group, a Ci_i 0 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci_i 0 alkyl group, the C 2 - 6 alkenyl group, the C 2 - 6 alkynyl group, the C 1 - I0 alkoxy group, the C 1-10 alkylcarbonyloxy group, the Ci-io alkoxycarbonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl . groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H,
  • the Ci -I0 alkyl groups, the C 2 -Io alkenyl groups, the C2-10 alkynyl groups, the C 2-9 heterocyclic groups, the C 1-10 alkoxy groups, the C 1-10 thioalkyl groups, the C 1-10 alkylcarbonyl groups, the mono- or (U-C 1-10 alkylamino groups, the C 1-10 alkylcarbonyloxy groups, the C 1-10 alkoxycarbonyl groups and the C 1-10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of
  • L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci -I0 alkyl group, a C 2 - 6 alkenyl group, a C 2 _e alkynyl group, a Ci -I0 alkoxy group, a Ci -10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C x-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2 _ 6 alkynyl group, the Ci-io alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, hal
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH, -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH and C ⁇ 10 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol
  • L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1 - I0 alkyl group, a C 2 .
  • R 3 is any one of the following heterocyclic groups :
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H 7 -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH, -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH, C 1 - I0 alkoxycarbonyl groups, C 1 -X 0 alkyl groups, C 2 - 10 alkenyl groups, C 2 -I 0 alkynyl groups, C 2 - 9 heterocycl
  • L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci- I0 alkyl group, a C 2 .
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH, -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH and Ci_ 10 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol
  • the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the 1-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl
  • the Ci- I0 alkoxy groups, the C 1-10 thioalkyl groups, the C 1-10 alkylcarbonyl groups, the mono- or di-C 1-10 alkylamino groups, the C 1-10 alkylcarbonyloxy groups,- the C 1-10 alkoxycarbonyl groups, the C 1 -I 0 alkylcarbonylamino groups and the following aryl groups and heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) :
  • Aryl groups a phenyl group, thienyl groups (a 2- thienyl group and a 3-thienyl group) , furyl groups (a 2- furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4- pyridyl group) , quinolyl groups (a 2-quinolyl group, a 3- quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5- isoquinolyl group, a 6-isoquinolyl group, a
  • Heterocyclic groups a 1, 3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1, 2,4-oxadiazole group, a 1, 2, 4-thiadiazole group, a 1, 2, 5-oxadiazole group, a 1,2, 5-thiadiazole group, a 1,2-oxazole group and a 1,2- thiazole group) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof .
  • the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the 1-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consist
  • Ci_i 0 alkoxycarbonyl groups Ci-io alkyl groups, C 2-10 alkenyl groups, C 2 _i 0 alkynyl groups, C 2 - 9 heterocyclic groups, Ci-I 0 alkoxy groups, Ci_i 0 thioalkyl groups, C 1-10 alkylcarbonyl groups, mono- or di- Ci-io alkylamino groups, C 1-10 alkylcarbonyloxy groups, C 1 - K3 alkoxycarbonyl groups and Ci_i 0 alkylcarbonylamino groups (the Ci-io alkyl groups, the C 2 .
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H,
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH, -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH and C 1-10 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • substituents selected from the group consisting of hydroxyl groups, amino groups, thiol
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH, -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH, Ci-I 0 alkoxycarbonyl groups, Ci- I0 alkyl groups, C 2 -io alkenyl groups, C 2-10 alkynyl groups, C 2 -g heterocyclic groups, C 1-10 alkyl
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH, -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH and Ci -I0 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • substituents selected from the group consisting of hydroxyl groups, amino groups, thi
  • L 4 is an oxygen atom or a sulfur atom
  • R 3 is an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a s-butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 4- pentynyl group, a 1-methyl-2-butynyl group, a l-methyl-3- butynyl group,
  • the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of
  • Aryl groups a phenyl group, thienyl groups (a 2- thienyl group and a 3-thienyl group) , furyl groups (a 2- furyl group and a 3-furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4- pyridyl group), quinolyl groups (a 2-quinolyl group, a 3- quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5- isoquinolyl group, a 6-isoquinolyl group, a
  • Heterocyclic groups a 1,3,4-oxadiazole group, a 1, 3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1, 2,4-thiadiazole group, a 1,2, 5-oxadiazole group, a
  • L 4 is an oxygen atom or a sulfur atom
  • R 3 is a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a s-butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c- hexyl group, an ethynyl group, a 1-propynyl group, a 2- propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a
  • the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected '
  • L 4 is an oxygen atom or a sulfur atom
  • R 3 is a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a c-propyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n- butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of
  • L 4 is an oxygen atom or a sulfur atom
  • R 3 is a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a c-propyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the ir-propyl group, the n- butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H,
  • Ci -10 alkoxycarbonyl groups C 1 -K 3 alkyl groups, C2-10 alkenyl groups, C 2 -].o alkynyl groups, C 2 - 9 heterocyclic groups, Ci- 10 alkoxy groups, Ci_i 0 thioalkyl groups, C 1 - K ) alkylcarbonyl groups, mono- or di-Ci_io alkylamino groups, C 1-10 alkylcarbonyloxy groups, Ci- I0 alkoxycarbonyl groups and Ci- I0 alkylcarbonylamino groups (the C 1 - I0 alkyl groups, the C2- 10 alkenyl groups, the C 2 _ 10 alkynyl groups, the C 2 .
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups , cyanocarbamoyl groups , sulfamoyl groups , hydroxysulf amoyl groups , cyanosulf amoyl groups , tetrazole groups , -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H 7 -CH 2 CH 2 CO 2 H, -CH 2 OH , -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH and Ci_i 0 alkoxycarbonyl groups ) , tautomers , prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof .
  • substituents selected from the groups consisting of
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H,
  • lo alkylcarbonylamino groups (the C 1 - X0 alkyl groups, the C 2 -; LO alkenyl groups, the C 2 - 10 alkynyl groups, the C 2 -g heterocyclic groups, the C 1 - I0 alkoxy groups, the C ⁇ . lo thioalkyl groups, the C 1 - X0 alkyLcarbonyl groups, the mono- or di-Ci-io alkylamino groups, the C ⁇ .
  • lo alkylcarbonyloxy groups, the C 1 - X0 alkoxycarbonyl groups and the C 1 - I0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH 2 CO 2 H, -OCH 2 CO 2 H, -NHCH 2 CO 2 H, -CH 2 CH 2 CO 2 H, -CH 2 OH, -OCH 2 OH, -NHCH 2 OH, -CH 2 CH 2 OH and Ci -10 alkoxycarbonyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups,

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Abstract

A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

Description

DESCRIPTION
3-ETHYLIDENΞHYDRAZIN0 SUBSTITUTED HETEROCYCLIC COMPOUNDS AS THROMBOPOIΞTIN RECEPTOR ACTIVATORS
BACKGROUND OF THE INVENTION TECHNICAL FIELD
The present invention relates to preventive, therapeutic and improving agents having affinity for and io agonistic action on the thrombopoietin receptor for diseases against which activation of the thrombopoietin receptor is effective. Specifically, it relates to pharmaceutical compositions comprising compounds which increase platelets through stimulation of differentiation
15 and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or compounds for therapeutic angiogenesis or with anti- arteriosclerosis action that stimulate differentiation and proliferation of vascular endothelial cells and
20 endothelial progenitor cells.
BACKGROUND ART
Thrombopoietin is a cytokine consisting of 332 amino acids that increases platelet production by stimulating 25 differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes mediated by its receptor and therefore is promising as a drug for hematological disorders. Recent reports that it stimulates differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells have raised expectations of therapeutic angiogenesis, anti- arteriosclerosis and prevention of cardiovascular events (for example, non-patent document 1, non-patent document 2 and non-patent document 3) .
Biologically active substances which have been known so far to regulate platelet production through the thrombopoietin receptor include, in addition to thrombopoietin itself, low molecular weight peptides having affinity for the thrombopoietin receptor (for example, patent document 1, patent document 2, patent document 3 and patent document 4) . As a result of search for nonpeptidic low molecular weight compounds that increase platelet production mediated by the thrombopoietin receptor, low molecular weight compounds having affinity for the thrombopoietin receptor have been reported (for example, patent document 5 to patent document 26) .
1) Applications filed by Hokuriku Seiyaku Co. , Ltd. relating to 1,4-benzodiazepine derivatives (patent documents 5 and 6)
2) International Laid-open Patent Applications filed by Shionogi & Co., Ltd. (patent documents 7-10)
3) International Laid-open Patent Applications filed by• SmithKline Beecham Corp (patent documents 11-19) 4) Japanese Laid-open Patent Application filed by Torii Pharmaceutical Co., Ltd. (patent document 20)
5) International Laid-open Patent Application filed by Roche Diagnostics GMBH (patent document 21) 6) International Laid-open Patent Application filed by Yamanouchi Pharmaceutical Co., Ltd. (patent document 22 and 23)
7) Japanese Laid-open Patent Application filed by Japan Tabacco Inc. (patent document 24) 8) Japanese Laid-open Patent Applications filed by Nissan Chemical Industries, Ltd. (patent documents 25 and 26) Patent document 1 JP-A-10-72492 Patent document 2 W096/40750 Patent document 3 WO96/40189 Patent document 4 W098/25965
Patent document 5 JP-A-11-1477 Patent document 6 JP-A-11-152276 Patent document 7 WOOl/07423 Patent document 8 WO01/53267 Patent document 9 WO02/059099 Patent document 10 WO02/059100 Patent document 11 WO00/35446 Patent document 12 WOO0/66112 Patent document 13 WO01/34585 Patent document 14 WOOl/17349 Patent document 15 WOOl/39773 Patent document 16 WOO1/21180 Patent document 17 WO01/89457 Patent document 18 WO02/49413 Patent document 19 WO02/085343 Patent document 20 JP-A-2001-97948 Patent document 21 WO99/11262 Patent document 22 WO02/062775 Patent document 23 WO03/062233 Patent document 24 JP-A-2003-238565 Patent document 25 WO04/033433 Patent document 26 WO04/108683
Non-patent document 1 Microvasc. Res., 1999: 58, p.108-113
Non-patent document 2 Circ. Res., 1999: 84, p.785- 796 Non-patent document 3 Blood 2001:98, p.71a-72a
DISCLOSURE OF THE INVENTION
Thrombopoietin and low molecular weight peptides having affinity for the thrombopoietin receptor are likely to be easily degraded in the gastrointestinal tract and are usually difficult to orally administer. As to thrombopoietin itself, the appearance of anti- thrombopoietin antibodies have been reported.
Besides, though it is probably possible to orally administer nonpeptidic low molecular weight compounds, no practical drugs have been put on the market.
Therefore, orally administrable low molecular weight compounds having excellent affinity for and agonistic action on the thrombopoietin receptor as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective have been demanded. Specifically, low molecular weight compounds which can serve as platelet increasing agents or increasing agents for other blood cells by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or low molecular weight compounds which can be used for therapeutic angiogenesis or as preventive and therapeutic agents for arteriosclerosis by stimulating endothelial cells and endothelial progenitor cells have been demanded. The present inventors conducted extensive research to find low molecular weight compounds having affinity for and agonistic action on the thrombopoietin receptor, and as a result, found that the compounds of the present invention have high affinity and agonistic action which enable them to show potent platelet increasing action by stimulating differentiation and proliferation of megakaryocytic progenitor cells and megakaryocytes. The present invention was accomplished on the basis of this discovery. Namely, the present invention relates to: 1. A compound represented by the formula (1)
Figure imgf000007_0001
wherein A is a nitrogen atom or CR4 (wherein R4 is a hydrogen atom, a hydroxy1 group (the hydroxyl group may be substituted with a C2-β alkenyl group or a C2.6 alkynyl group) , a thiol group (the thiol group may be substituted with a C1-I0 alkyl group, a C2-6 alkenyl group, a C2.6 alkynyl group or a Ci-I0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2_6 alkynyl groups) , a formyl group, a .halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2~6 alkenyl group, a C2_s alkynyl group, a C1-X0 alkylcarbonylamino group, a mono- or di-Ci-io alkylamino group, a Ci-I0 alkoxy group (the C1-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-io alkylcarbonylamino group, the mono- or di-C1-I0 alkylamino group and the Cx-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, Cx-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Cx-I0 alkylcarbonylamino groups, amino groups, mono- or di-Cx-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-3.4 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) , a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) , SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-g heterocyclic group, a Ci-I0 alkoxy group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group and the C1-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci_lo alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2.14 aryloxy groups (the C2-14 aryl groups and the C2_14 aryloxy groups may be substituted with one or more C1-S alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with, one or more halogen atoms) , C2-s alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-K3 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups), a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, Ci-10 alkylcarbonyl' groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups (the C2.14 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the C1.6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2.14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_10 alkyl groups (the C1-J-0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-H-0 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)ml-E- (CH2)m2- (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2.6 alkenyl group, a C2.6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the C^10 alkoxycarbonyl group and the C1-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1-K) alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-Hj alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the C1-I5 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkeήyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, QL_IQ alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups)), and each of ml and m2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5) ) ) ) , B is an oxygen atom, a sulfur atom or NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-io alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-io alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the C1-I0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the Cx-I0 alkoxy group, the Ci-io alkylcarbonyloxy group, the Cx-10 alkoxycarbonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Cx-I0 alkoxy groups, Ci_io alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Ci-i0 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-X4 aryloxy groups (the C2_X4 aryl groups and the C2-X4 aryloxy groups may be substituted with one or more Cx-6 alkyl groups (the Cx-6 alkyl groups may be substituted with one or more halogen atoms), or one or more halogen atoms) ) , a C2-X4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-X0 alkyl groups (the Cx_lo alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Cx-10 alkoxy groups, Cx-I0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups) or a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups)) (provided that when A is a nitrogen atom, B is not NH) , R1 is a C2-I4 aryl group (the C2-14 aryl group may be substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci_i0 alkyl groups, C2.6 alkenyl groups, C2-6 alkynyl groups, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups (the Ci-I0 alkyl groups, the C2-6 alkenyl groups, the C2-6 alkynyl groups, the Ci_i0 alkoxy groups, the Ci_i0 alkylcarbonyl groups, the Ci-I0 alkylcarbonyloxy groups and the Ci-I0 alkoxycarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the CX-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , C2-I4 aryl groups (the C2-I4 aryl groups may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) , thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or two substituents selected from the group consisting of formyl groups, Ci-I0 alkyl groups, C2-6 alkenyl groups, C2-6 alkynyl groups and C1-10 alkylcarbonyl groups (the C1-10 alkyl groups, the C2-6 alkenyl groups, the C2-6 alkynyl groups and the Ci-10 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1^0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2_14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) ) ,
L1 is a bond, CR10R11 (wherein each of R10 and R11 is independently a hydrogen atom or a C1-6 alkyl group (the Ci-6 alkyl group may be substituted with one or more halogen atoms) ) , an oxygen atom, a sulfur atom or NR12 (wherein R12 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2_e alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups)) , X is OR13, SR13 or NR14R15 (wherein R13 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group (the Ci-I0 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group and the C1-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, C1-O-0 alkylcarbonyl groups, C1-X0 alkylcarbonyloxy groups, Cx-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-1.4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-S alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , and each of R14 and R15 is independently a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Ci-.6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) ) ,
R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1I10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-i4 aryl groups and the C2.14 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1^0 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) ,
L2 is a bond, CR34R35 (wherein each of R34 and R35 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms) ) , an oxygen atom, a sulfur atom or NR16 (wherein R16 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci-io alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2.14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2_14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1^10 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1-10 alkylcarbonyl groups, Cχ-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.14 aryl groups and C2-14 aryloxy groups)) , L3 is a bond, CR17R18 (wherein each of R17 and R18 is independently a hydrogen atom, a C1-J-0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-O-0 alkoxy group, a Ci-io alkylcarbonyl group (the Ci_10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) ) , an oxygen atom, a sulfur atom or NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a Ci-io alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-s alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-24 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups)),
Y is an oxygen atom, a sulfur atom or NR23 (wherein R23 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-10 alkyl group, a C2.5 alkenyl group, a C2-6 alkynyl group, a Ci-10 alkoxy group, a Ci-10 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the Ci_i0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_i4 aryl groups and C2-I4 aryloxy groups (the C2_i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-S alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the C1-K) alkyl groups may be substituted with one or more halogen atoms), C2.6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, QL-IO alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups) ) ,
L4 is a bond, CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a C1-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a CI-IQ alkoxy group, a Ci-io alkylcarbonyl group (the Ci_i0 alkyl group, the C2.6 alkenyl group, the C2.6 alkynyl group, the Cα-i0 alkoxy group and the Ci_i0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, CI-IQ alkoxy groups, Ci_i0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Cx-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-1.4 aryl groups and C2.14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2_6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting- of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-i4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-K) alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and
When L4 is a bond, R3 is a methyl group (the methyl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups, C2_10 alkenyl groups, C2-10 alkynyl groups, C2-S heterocyclic groups, C1-10 alkoxy groups, C1-10 thioalkyl groups, Ci-10 alkylcarbonyl groups, mono- or di- C1-I0 alkylamino groups, Ci-10 alkylcarbonyloxy groups, Cx_10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups (the Ci-io alkyl groups, the C2-I0 alkenyl groups, the C2-io alkynyl groups, the C2-g heterocyclic groups, the Cx-10 alkoxy groups, the C1-K3 thioalkyl groups, the Ci-I0 alkylcarbonyl groups, the mono- or di-Ci_i0 alkylamino groups, the C1^0 alkylcarbonyloxy groups, the Ci-I0 alkoxycarbonyl groups and the Ci-I0 alkylcarbonylamino groups may be optionally substituted with one or more
C2-i4 aryl groups (the C2-i4 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4 (wherein W1 is (CR24R25)n (wherein each of R24 and R25 is independently a hydrogen atom or a C1-6 alkyl group (the Ci_6 alkyl group may be substituted with one or more halogen atoms) , or R24 and R25 mean, together with each other, O= or S=, and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36 (wherein R36 is a hydrogen atom, a Ci-6 alkyl group, a formyl group or a Ci-6 alkylcarbonyl group) , each of W2 and W3 is independently a hydrogen atom or a Ci_3 alkyl group (the C1.3 alkyl group may be substituted with one or more halogen atoms) , m is 0, 1, 2 or 3, and W4 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a Ci-io alkoxy group, a C1-I0 alkylcarbonyloxy group, a Ci-io alkylcarbonylamino group, a mono- or (U-C1-I0 alkylamino group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group, the C1-H0 alkoxy group, the C1-X0 alkylcarbonyloxy group, the C1-X0 alkylcarbonylamino group and the mono- or di-C1-H0 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-J-0 alkoxy groups, C1-J-0 alkylcarbonyl groups, C1-H0 alkylcarbonyloxy groups, C1-H0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-H0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-H4 aryl groups and C2-H4 aryloxy groups (the C2-14 aryl groups and the C2_14 aryloxy groups may be substituted with one or more C1-S alkyl groups (the Cπ-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-I-4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-lo alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-H0 alkoxy groups, C1-H0 alkylcarbonyl groups, C1-H-0 alkylcarbonyloxy groups, C1-H0 alkoxycarbonyl groups, C1-Ho alkylcarbonylamino groups, amino groups, mono- or di-Ci-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, thiol groups, phosphonic acid groups, sulfonic acid groups, tetrazole groups, C2-i4 aryl groups and C2-I4 aryloxy groups (the C2-i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-10 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28, SOR28, COR28 (wherein R28 is a hydroxyl group, a protected hydroxyl group, a Ci-10 alkyl group, a C2_6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a Ci_i0 alkoxy group (the Ci_i0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group and the Ci_i0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_s alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group, a C2-I4 aryloxy group (the C2-I4 aryl group and the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-i4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or NR29R30 (wherein each of R29 and R30 is independently a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a Cx-I0 alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group, a Ci_i0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a C1-I0 alkylsulfonyl group, a Ci_i0 alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-io alkoxycarbonyl group, the Cx-I0 alkylsulfonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, CV10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl group, sulfonyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups (the Ci-I0 alkoxy groups may be substituted with one or more halogen atoms), Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2.14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more QL_6 alkyl groups (the Ci-5 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl group, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups,
Ci-io alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-io alkoxycarbonyl groups, CX-I0 alkylcarbonylamino groups, amino groups, mono- or CU-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Cα-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), or R29 and R30, together with each other means - (CH2)m3-G- (CH2)m4- (wherein G is an oxygen atom, a sulfur atom, CR31R32 (wherein each of R31 and R32 is independently a hydrogen atom, a C1-X0 alkyl group, a C2-I4 aryl group, a Ci-I0 alkoxy group, a C2-I4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a Ci_i0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the Cχ-10 alkoxy group, the C1-X-0 alkylcarbonyloxy group, the C1-X0 alkoxycarbonyl group and the Ci_10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-X0 alkylcarbonyl groups, C1-X0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Cα_io alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, QL-I0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-π.4 aryl groups and the C2_14 aryloxy groups may be substituted with one or more C1-5 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))) , a tetrazole group or a phosphonic acid group) ) or one or more substituents independently represented by -W5(CW6W7)ml0W8 (wherein W5, W6, W7 and mlO are the same as W1, W2, W3 and m, respectively, W1, W2, W3 and m are the same as defined above, and W8 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-io alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group, a C2-B heterocyclic group, a Ci-I0 alkoxy group, a C1-X0 alkylcarbonyloxy group, a Ci-I0 alkylcarbonylamino group, a mono- or di-Cx-I0 alkylamino group (the Ci_xo alkyl group, the C2-6 alkenyl group, the C2-e alkynyl group, the C2-9 heterocyclic group, the Ci-10 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkylcarbonylamino group and the mono- or di- Ci_i0 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, CI-IQ alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the C1S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28a, SOR28a, COR28a (wherein R28a is the same as R28, and R28 is the same as defined above) , a tetrazole group or a phosphonic acid group) ) and substituents independently represented by -W9 (CW10W11)mllW12 (wherein W9, W10, W11, W12 and mil are the same as W1, W2, W3, W8 and m, respectively, and W1, W2, W3, W8 and m are the same as defined above) ) , a C2-Io alkyl group, a C2-io alkenyl group, a C2-io alkynyl group or a C2-9 heterocyclic group (the C2-10 alkyl group, the C2-I0 alkenyl group, the C2-I0 alkynyl group and the C2. 9 heterocyclic group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups, C2-10 alkenyl groups, C2-10 alkynyl groups, C2-g heterocyclic groups, C1-Ho alkoxy groups, C1-H0 thioalkyl groups, C1-Io alkylcarbonyl groups, mono- or di-Ci-πo alkylamino groups, C1-H0 alkylcarbonyloxy groups, C1-H0 alkoxycarbonyl groups, C1-H0 alkylsulfonyl groups, C1-10 alkylaminocarbonyl groups, C1-Ho alkylaminosulfonyl groups, C1-Ho dialkylaminocarbonyl groups, C1-Ho alkylcarbonylamino groups (the C1-Ho alkyl groups, the C2-1O alkenyl groups, the C2.lo alkynyl groups, the C2-9 heterocyclic groups, the C1-Ho alkoxy groups, the C1-Ho thioalkyl groups, the C1-Ho alkylcarbonyl groups, the mono- or di-Cπ-πo alkylamino groups, the C1-H0 alkylcarbonyloxy groups, the C1-Ho alkoxycarbonyl groups, the C1-H0 alkylsulfonyl groups, the C1-Ho alkylaminocarbonyl groups, the C1-H0 alkylaminosulfonyl groups, the C1-Ho dialkylaminocarbonyl groups and the C1-Ho alkylcarbonylamino groups may be optionally substituted with one or more C2-H4 aryl groups (the C2-H4 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4
(wherein W1, W2, W3, W4 and m are the same as defined above) ) or one or more substituents independently represented by -W5 (CW6W7)ml0W8 (wherein W5, W6, W7, W8 and mlO are the same as defined above) ) , substituents independently represented by W9 (CW10W11)mnW12 (wherein W9, W10, W11, W12 and mil are the same as defined above) and C2-i4 aryl groups (the C2-i4 aryl groups may be optionally substituted with one or more substituents independently represented by -W13 (CW14W15)ml2W16 (wherein W13, W14, W15, W16 and ml2 are the same as W1, W2, W3, W4 and m, respectively, and W1, W2, W3, W4 and m are the same as defined above) ) ) , or when L4 is CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2.6 alkynyl group, a Ci-io alkoxy group, a Ci-io alkylcarbonyl group (the Ci_i0 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Cx-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Cx-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_i4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-i4 aryl group (the C2-i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2_i4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2.6 alkenyl group, a C2.6 alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci_i0 alkoxycarbonyl group, a C1-I0 alkylcarbonyl group (the C1-JL0 alkyl group, the C2.6 alkenyl group, the C2.6 alkynyl group, the C1-X0 alkoxy group, the C1-X0 alkylcarbonyloxy group, the C1-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_10 alkoxy groups, Ci-io alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or CU-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , R3 is a C1-10 alkyl group, a C2-lo alkenyl group, a C2-10 alkynyl group, a C2-S heterocyclic group, a Cx-I0 alkoxy group, a Ci-I0 thioalkyl group, a C1-I0 alkylcarbonyl group, a mono- or di-Ci-ao alkylamino group, a Ci-io alkylcarbonyloxy group, a C1-X0 alkoxycarbonyl group or a Ci-10 alkylcarbonylamino group (the C1-I0 alkyl group, the C2-10 alkenyl group, the C2-Io alkynyl group, the C2.9 heterocyclic group, the Ci-io alkoxy group, the Ci-10 thioalkyl group, the Ci-I0 alkylcarbonyl group, the mono- or di-Ci_i0 alkylamino group, the Ci-I0 alkylcarbonyloxy group, the C1-K3 alkoxycarbonyl group and the Ci_i0 alkylcarbonylamino group may be optionally substituted with one or more substituents selected from the group consisting of Ci-io alkyl groups, C2-I0 alkenyl groups, C2-I0 alkynyl groups, C2-g heterocyclic groups, Ci-I0 alkoxy groups, Ci-I0 thioalkyl groups, C1-I0 alkylcarbonyl groups, mono- or di- Ci-I0 alkylamino groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups (the Ci-I0 alkyl groups, the C2-I0 alkenyl groups, the C2-I0 alkynyl groups, the C2-9 heterocyclic groups, the C1-K) alkoxy groups, the Ci-I0 thioalkyl groups, the Ci-I0 alkylcarbonyl groups, the mono- or di-Ci-io alkylamino groups, the Ci-I0 alkylcarbonyloxy groups, the Ci_i0 alkoxycarbonyl groups and the Ci-io alkylcarbonylamino groups may be optionally substituted with one or more C2. i4 aryl groups (the C2.14 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4 (wherein W1, W2, W3, W4 and m are the same as defined above) ) or one or more substituents independently represented by -W5 (CW6W7)ml0W8 (wherein W5, W6, W7, W8 and mlO are the same as defined above) ) , substituents independently represented by -W9 (CW10W11J11111W12 (wherein W9, W10, W11, W12 and mil are the same as defined above) and C2-i4 aryl groups (the C2-i4 aryl groups may be optionally substituted with one or more substituents independently represented by -W13(CW14W15)ml2W16 (wherein W13, W14, W15, W16 and ml2 are the same as defined above) ) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
2. The compound according to 1, wherein L4 is a bond, R3 is a methyl group (the methyl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups, C2-io alkenyl groups, C2-io alkynyl groups, C2-9 heterocyclic groups, C1- 10 alkoxy groups, Ci-10 thioalkyl groups, Ci_i0 alkylcarbonyl groups, mono- or di-Ci_10 alkylamino groups, C1-I0 alkylcarbonyloxy groups, C^10 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups (the C1-I0 alkyl groups, the C2-:LO alkenyl groups, the C2_10 alkynyl groups, the C2_9 heterocyclic groups, the Ci_i0 alkoxy groups, the Cχ.lo thioalkyl groups, the Ci-10 alkylcarbonyl groups, the mono- or di-C1-I0 alkylamino groups, the C1-X0 alkylcarbonyloxy groups, the Ci-10 alkoxycarbonyl groups and the Ci_i0 alkylcarbonylamino groups may be optionally substituted with one or more C2-i4 aryl groups (the C2-I4 aryl groups may be optionally substituted with one or more substituents independently represented by -W1ICW2W3)mW4 (wherein W1 is (CR24R25)n (wherein each of R24 and R25 is independently a hydrogen atom or a Ci-6 alkyl group (the Ci-6 alkyl group may be substituted with one or more halogen atoms) , or R24 and R25 mean, together with each other, 0= or S=, and n is 0, 1, 2 or 3) , an oxygen atom, a sulfur atom or NR36 (wherein R36 is a hydrogen atom, a Ci_6 alkyl group, a formyl group or a Ci_6 alkylcarbonyl group) , each of W2 and W3 is independently a hydrogen atom or a Ci-3 alkyl group (the Ci-3 alkyl group may be substituted with one or more halogen atoms) , m is 0, 1, 2 or 3, and W4 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-io alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a Ci-io alkoxy group, a C1-X0 alkylcarbonyloxy group, a Ci-io alkylcarbonylamino group, a mono- or di-Ci_i0 alkylamino group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group, the Ci-10 alkoxy group, the Ci-io alkylcarbonyloxy group, the Ci-I0 alkylcarbonylamino group and the mono- or di-Ci-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, C1-I0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-CX-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-i4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Cx-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_s alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Cx-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, thiol groups, phosphonic acid groups, sulfonic acid groups, tetrazole groups, C2-i4 aryl groups and C2-I4 aryloxy groups (the C2_i4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci_i0 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28, SOR28, COR28 (wherein R28 is a hydroxyl group, a protected hydroxyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a C1-I0 alkoxy group (the C1-X0 alkyl group, the C2-β alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group and the Cχ-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, C1^0 alkylcarbonyl groups, C1-X0 alkylcarbonyloxy groups, C1-X0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2.14 aryloxy groups (the C2-14 aryl groups and the C2_14 aryloxy groups may be substituted with one or more Cχ-6 alkyl groups (the C1^ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group, a C2-14 aryloxy group (the C2.14 aryl group and the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-IL0 alkyl groups (the C1-X0 alkyl groups may be substituted with one or more halogen atoms) , C2-β alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, C1-IL0 alkylcarbonyl groups, Cχ-10 alkylcarbonyloxy groups, C;L-10 alkoxycarbonyl groups, Cχ.10 alkylcarbonylamino groups, amino groups, mono- or di-C;L_10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the d-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or NR29R30 (wherein each of R29 and R30 is independently a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a Ci_10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci_10 alkoxy group, a C1.1Q alkylcarbonyloxy group, a Ci_i0 alkoxycarbonyl group, a C1-I0 alkylsulfonyl group, a Ci-I0 alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the Ci-αo alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group, the Ci-I0 alkylsulfonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-io alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl group, sulfonyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups (the C1-X0 alkoxy groups may be substituted with one or more halogen atoms) , Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Ci-S alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) or a C2_i4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2_6 alkynyl groups, carboxyl group, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Ci-io alkylcarbonyl groups, Ci_10 alkylcarbonyloxy groups, Ci-io alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2.14 aryloxy groups (the C2.14 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) , or R29 and R30, together with each other means - (CH2)m3-G- (CH2)m4- (wherein G is an oxygen atom, a sulfur atom, CR31R32 (wherein each of R31 and R32 is independently a hydrogen atom, a C1-10 alkyl group, a C2-I4 aryl group, a C1.10 alkoxy group, a C2-I4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-I0 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the C1^ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))), a tetrazole group or a phosphonic acid group) ) or one or more substituents independently represented by -W5 (CW6W7)ml0W8 (wherein W5, W6, W7 and mlO are the same as W1, W2, W3 and m, respectively, W1, W2, W3 and m are the same as defined above, and W8 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a Ci_io alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a C2.9 heterocyclic group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-io alkylcarbonylamino group, a mono- or (U-C1-I0 alkylamino group (the C1-J-0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the C2-9 heterocyclic group, the Ci-io alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-io alkylcarbonylamino group and the mono- or di- Cx-IO alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ,
SO2R28a, SOR28a, COR28a (wherein R28a is the same as R28, and R28 is the same as defined above) , a tetrazole group or a phosphonic acid group) ) and substituents independently represented by -W9 (CW10W11)mnW12 (wherein W9, W10, W11, W12 and mil are the same as W1, W2, W3, W8 and m, respectively, and W1, W2, W3, W8 and m are the same as defined above) ) , a C2-I0 alkyl group, a C2-I0 alkenyl group, a C2-I0 alkynyl group or a C2.9 heterocyclic group (the C2-I0 alkyl group, the C2-I0 alkenyl group, the C2-I0 alkynyl group and the C2- g heterocyclic group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups, C2-I0 alkenyl groups, C2-I0 alkynyl groups, C2-9 heterocyclic groups, Ci_i0 alkoxy groups, C1-I0 thioalkyl groups, Ci.10 alkylcarbonyl groups, mono- or (U-C1-10 alkylamino groups, C1-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, Ci_io alkylaminocarbonyl groups, C1-10 dialkylaminocarbonyl groups, C1-H0 alkylcarbonylamino groups (the C1-I0 alkyl groups, the C2-io alkenyl groups, the C2-10 alkynyl groups, the C2-9 heterocyclic groups, the Ci_i0 alkoxy groups, the Ci-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or CIi-C1-I0 alkylamino groups, the C1-I0 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups, the C1-10 alkylaminocarbonyl groups, the C1-10 dialkylaminocarbonyl groups and the C1-10 alkylcarbonylamino groups may be optionally substituted with one or more C2-14 aryl groups (the C2-14 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4 (wherein W1, W2, W3, W4 and m are the same as defined above) ) or one or more substituents independently represented by -W5 (CW6W7)ml0W8 (wherein W5, W6, W7, W8 and mlO are the same as defined above) ) , substituents independently represented by W9 (CW10W11)mllW12 (wherein W9, W10, W11, W12 and mil are the same as defined above) and C2-14 aryl groups (the C2_14 aryl groups may be optionally substituted with one or more substituents independently represented by -W13 (CW14W15)ml2W16 (wherein W13, W14, W15, W16 and ml2 are the same as W1, W2, W3, W4 and m, respectively, and W1, W2, W3, W4 and m are the same as defined above) ) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
3. The compound according to 1, wherein L4 is CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci_i0 alkoxy group, a Ci_i0 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally .substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, Ci-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) .or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, Ci.10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a Ci_i0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-i4 aryl group (the C2-i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the Cx-I0 alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Cx-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2_i4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and R3 is a Ci-I0 alkyl group, a C2-I0 alkenyl group, a C2-I0 alkynyl group, a C2-9 heterocyclic group, a Ci-I0 alkoxy group, a Ci-I0 thioalkyl group, a Ci_i0 alkylcarbonyl group, a mono- or di-Ci-I0 alkylamino group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group or a Ci-I0 alkylcarbonylamino group (the Ci-I0 alkyl group, the C2-I0 alkenyl group, the C2-I0 alkynyl group, the C2.9 heterocyclic group, the Ci-I0 alkoxy group, the Ci_i0 thioalkyl group, the Ci-I0 alkylcarbonyl group, the mono- or di-Ci-I0 alkylamino group, the Ci-io alkylcarbonyloxy group, the Ci_10 alkoxycarbonyl group and the C1-I0 alkylcarbonylamino group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups, C2-10 alkenyl groups, C2-10 alkynyl groups, C2-9 heterocyclic groups, Ci-io alkoxy groups, Ci_i0 thioalkyl groups, C1-I0 alkylcarbonyl groups, mono- or di- Ci-io alkylamino groups, C1-H0 alkylcarbonyloxy groups, C1^0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups (the C1-I0 alkyl groups, the C2-10 alkenyl groups, the C2.10 alkynyl groups, the C2_9 heterocyclic groups, the Ci-I0 alkoxy groups, the C1-X0 thioalkyl groups, the Ci_io alkylcarbonyl groups, the mono- or di-Ci-i0 alkylamino groups, the Ci-I0. alkylcarbonyloxy groups, the Ci_i0 alkoxycarbonyl groups and the Ci-I0 alkylcarbonylamino groups may be optionally substituted with one or more C2- 14 aryl groups (the C2.14 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4 (wherein W1 is (CR24R25)n (wherein each of R24 and R25 is independently a hydrogen atom or a C1-^ alkyl group (the Cx-6 alkyl group may be substituted with one or more halogen atoms) , or R24 and R25 mean, together with each other, 0= or S=, and n is 0, 1, 2 or 3) , an oxygen atom, a sulfur atom or NR36 (wherein R36 is a hydrogen atom, a C1-S alkyl group, a formyl group or a C1-S alkylcarbonyl group) , each of W2 and W3 is independently a hydrogen atom or a Ci-3 alkyl group (the C1-3 alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W4 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a C1-I0 alkoxy group, a C1-10 alkylcarbonyloxy group, a Ci-10 alkylcarbonylamino group, a mono- or di-Ci-I0 alkylamino group (the C1-Q-0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-H0 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-IL0 alkylcarbonyloxy groups, Ci-io alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or CU-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, thiol groups, phosphonic acid groups, sulfonic acid groups, tetrazole groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-10 alkyl groups (the C1-J-0 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28, SOR28, COR28 (wherein R28 is a hydroxyl group, a protected hydroxyl group, a Cx-I0 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, Cx.10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2.14 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group, a C2-14 aryloxy group (the C2-I4 aryl group and the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the Cx-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Cx-I0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Cx-xo alkoxycarbonyl groups, Cx-X0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-X4 aryloxy groups (the C2_X4 aryl groups and the C2_X4 aryloxy groups may be substituted with one or more CX-6 alkyl groups (the Cx_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or NR29R30 (wherein each of R29 and
R30 is independently a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a Cx-xo alkyl group, a C2-6 alkenyl group, a C2.6 alkynyl group, a Cx-X0 alkoxy group, a C1.xo alkylcarbonyloxy group, a Cx_xo alkoxycarbonyl group, a Cx.xo alkylsulfonyl group, a C1-I0 alkylcarbonyl group (the Cx_xo alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the Cx_xo alkoxy group, the Ci-io alkylcarbonyloxy group, the C1-X0 alkoxycarbonyl group, the C1-I0 alkylsulfonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or- more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, C1-I0 alkylcarbonyl groups, C1-O-0 alkylcarbonyloxy groups, Cχ-10 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di-C1-X0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-K3 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl group, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, Ci_i0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_i4 aryl groups and C2-I4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , or R29 and R30, together with each other means - (CH2)m3-G- (CH2)m4- (wherein G is an oxygen atom, a sulfur atom, CR31R32 (wherein each of R31 and R32 is independently a hydrogen atom, a C1-I0 alkyl group, a C2-i4 aryl group, a Ci-io alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-I0 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a Ci-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-i4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2_14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-S alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and each of m.3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5) ) ) , a tetrazole group or a phosphonic acid group) ) or one or more substituents independently represented by -W5 (CW6W7)mloW8 (wherein W5, W6, W7 and mlO are the same as W1, W2, W3 and m, respectively, W1, W2, W3 and m are the same as defined above, and W8 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a C1-JL0 alkyl group, a C2_6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a Ci_i0 alkoxy group, a C1-I0 alkylcarbonyloxy group, a Ci-xo alkylcarbonylamino group, a mono- or di-Cα-i0 alkylamino group (the C1-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-g heterocyclic group, the Ci-io alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-io alkylcarbonylamino group and the mono- or di- C1-I0 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_10 alkoxy groups, Ci-10 alkylcarbonyl groups, C1-[L0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-K5 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2_14 aryloxy groups (the C2-U aryl groups and the C2-i4 aryloxy groups may be substituted with one or more C1-S alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28a, SOR28a, COR28a (wherein R28a is the same as R28, and R28 is the same as defined above) , a tetrazole group or a phosphonic acid group) ) , substituents independently represented by -W9 (CW10W11)mllW12 (wherein W9, W10, W11, W12 and mil are the same as W1, W2, W3, W8 and m, respectively, and W1, W2, W3, W8 and m are the same as defined above) and C2_14 aryl groups (the C2.14 aryl groups may be optionally substituted with one or more substituents independently represented by -W13 (CW14W15)ml2W16 (wherein W13, W14, W15, W16 and ml2 are the same as W1, W2', W3, W4 and m, respectively, and W1, W2, W3, W4 and m are the same as defined above) ) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
4. The compound according to any one of 1 to 3, wherein A is a nitrogen atom, and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
5. The compound according to any one of 1 to 3, wherein
A is a nitrogen atom, and B is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
6. The compound according to any one of 1 to 3, wherein A is a nitrogen atom, and B is NR9 other than NH (wherein R9 is a hydrogen, atom, a hydroxyl group, a formyl group, a C1-I0 alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group, a C1-X0 alkoxy group, a C1-I0 alkylcarbonyloxy group, a C1-ILo alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-I0 alkyl group, the C2-β alkenyl group, the C2-β alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_10 alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups) or a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Cx-10 alkoxy groups, Ci_i0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci_10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
7. The compound according to any one of 1 to 3, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl group or a C2_6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-X0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-X0 alkylcarbonylamino group, a mono- or di-Ci-10 alkylamino group, a Ci-I0 alkoxy group (the Cx-I0 alkyl group, the C2-6 alkenyl .group, the C2_6 alkynyl group, the Ci_i0 alkylcarbonylamino group, the mono- or di-Ci-10 alkylamino group and the Ci-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms), C2-6 alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) , a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci_io alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-10 alkylcarbonyl groups, QL-I0 alkylcarbonyloxy groups, QL_I0 alkoxycarbonyl groups, QL_I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) , SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a QL-IO alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a Ci-10 alkoxy group (the Cx-I0 alkyl group, the C2-β alkenyl group, the C2-β alkynyl group, the C2-9 heterocyclic group and the Ci-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Cx-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2.X4 aryloxy groups (the C2-X4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more CX-6 alkyl groups (the Cx-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Cx.10 alkyl groups (the Cx-xo alkyl groups may be substituted with one. or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Cx-I0 alkoxy groups, Cx.xo alkylcarbonyl groups, CX-X0 alkylcarbonyloxy groups, Cx-X0 alkoxycarbonyl groups, Cx-X0 alkylcarbonylamino groups, amino groups, mono- or di-CX-X0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.X4 aryl groups and C2_X4 aryloxy groups), a C2-X4 aryloxy group (the C2-i4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-I10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of. carboxyl groups, nitro'groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-14- aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms), C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)mi-E- (CH2)m2- (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a Ci-I0 alkyl group, a C2-I4 aryl group, a Ci-I0 alkoxy group, a C2_i4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci_i0 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci_i0 alkylcarbonyloxy group, a Ci_i0 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci_i0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-I0 alkoxy group, the C1-I0 alkylcarbonyloxy group, the C^10 alkoxycarbonyl group and the Ci_io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-i4 aryloxy groups (the C2-i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the CX-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-io alkoxycarbonyl groups, CI_IQ alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups)) , and each of ml and m2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5)))), and B is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 8. The compound according to any one of 1 to 3, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a Cz-β alkenyl group or a C2_6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-10 alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group or a Ci-I0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2_6 alkynyl group, a C1-10 alkylcarbonylamino group, a mono- or di-Ci-I0 alkylamino group, a Ci-I0 alkoxy group (the Ci_i0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkylcarbonylamino group, the mono- or di-Ci-io alkylamino group and the Cx-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-K3 alkylcarbonyl groups, C1-J-0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Cx-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2.14 aryl groups and the C2-X4 aryloxy groups may be substituted with one or more Cx_6 alkyl groups (the Cx-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, CI_IQ alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups) , a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups) , SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-G alkenyl group, the C2.6 alkynyl group, the C2-9 heterocyclic group and the C1-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, C1-X0 alkylcarbonyloxy groups, C!-10 alkoxycarbonyl groups, C1-H0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-xo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups (the C2-i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Cχ-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2_i4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-io alkyl groups (the Cχ-10 alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Cχ-10 alkoxy groups, C1-X0 alkylcarbonyl groups, Cχ-10 alkylcarbonyloxy groups, Cχ-10 alkoxycarbonyl groups, C1-I10 alkylcarbonylamino groups, amino groups, mono- or di-Cχ-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.14 aryl groups and C2.14 aryloxy groups) , a C2.14 aryloxy group (the C2.14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, Ci_lo alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the C1-X0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci_αo alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)mi-E- (CH2)m2- (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a Ci_lo alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, Ci_i0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-H0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-i4 aryl groups and the C2.14 aryloxy groups may be substituted with one or more C1-S alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Cλ-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) ) , and each of ml and m2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5)))), and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 9. The compound according to any one of 1 to 3, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group
(the hydroxyl group may be substituted with a C2.6 alkenyl group or a C2-6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-io alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group or a Ci-10 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci_i0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-lo alkylcarbonylamino group, a mono- or di-Ci-I0 alkylamino group, a Ci-I0 alkoxy group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-io alkylcarbonylamino group, the mono- or di-Ci-io alkylamino group and the Ci-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci_lo alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-S alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2_i4 aryl group (the C2_i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups) , a C2-i4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, C^10 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, C1-X0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-C!-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) , SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a Cα_i0 alkyl group, a C2_6 alkenyl group, a C2_6 alkynyl group, a C2-9 heterocyclic group, a Ci-I0 alkoxy group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2_9 heterocyclic group and the Ci_i0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-X4 aryl groups and C2-I4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the C1.6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2.14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_s alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, CX-I0 alkylcarbonylamino groups, amino groups, mono- or di-Cx-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.X4 aryl groups and C2-I4 aryloxy groups) , a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Cx-I0 alkyl groups (the CX-X0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1- 0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2_s alkynyl group, the C1-X0 alkylcarbonyloxy group, the C1-X0 alkoxycarbonyl group and the C1-X0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, Cχ-10 alkylcarbonyl groups, Cχ-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Cχ-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2.14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-io alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms), C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-i4 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)πn-E- (CH2)m2- (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a Cx-I0 alkyl group, a C2-i4 aryl group, a Ci-I0 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci_i0 alkoxy group, a C1-K3 alkylcarbonyloxy group, a Ci-10 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci_i0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the Ci_i0 alkoxy group, the Ci_i0 alkylcarbonyloxy group, the Ci_io alkoxycarbonyl group and the CX-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2~14 aryloxy groups (the C2-i4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, Cλ-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) ) , and each of ml and m.2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5)))), and B is NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2_6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-10 alkoxy group, the C1-X0 alkylcarbonyloxy group, the Ci-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-io alkyl groups may be substituted with one or more halogen atoms), C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-m alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-αo alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
10. The compound according to any one of 1 to 9, wherein L1' is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
11. The compound according to any one of 1 to 10, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
12. The compound according to any one of 1 to 11, wherein L3 is NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, .a Ci-I0 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci_i0 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Cx-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group, the Ci-I0 alkoxy group and the Ci-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, C1-I0 alkylcarbonyl groups, Ci_10 alkylcarbonyloxy groups, Cx-10 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-X0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1- 0 alkylcarbonyl groups, C1-I10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I10 alkylcarbonylamino groups, amino groups, mono- or
Figure imgf000084_0001
alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.14 aryl groups and C2-I4 aryloxy groups)) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
13. The compound according to any one of 1 to 11, wherein L3 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 14. The compound according to any one of 3 to 11, wherein L3 is the same as defined in 12, and L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-io alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci_10 alkylcarbonyloxy group, a Ci-io alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the C1-I0 alkyl group, the C2-β alkenyl group, the C2-e alkynyl group, the Cx-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-io alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-e alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-io alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-K5 alkoxy groups, C1-X0 alkylcarbonyl groups, C1-X0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-X0 alkylcarbonylamino groups, amino groups, mono- or di-Cχ-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-χ4 aryloxy groups) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 15. The compound according to any one of 3 to 11, wherein L3 is the same as defined in 13, and L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Cχ-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a Cχ.lo alkylcarbonyl group (the C1-XO alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the Cχ-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of .carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-S alkyl groups (the Cx-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-i4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, C1^10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof .
16. The compound according to 14 or 15, wherein L4 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
17. The compound according to any one of 2 and 4 to 11, wherein L3 is the same as defined in 12, and L4 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 18. The compound according to any one of 2 and 4 to 11, wherein L3 is the same as defined in 13, and L4 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
19. The compound according to any one of 14 to 18, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
20. The compound according to any one of 14 to 18, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 21. The compound according to 19 or 20, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
22. The compound according to any one of 19 to 21, wherein R3 is a C2-9 heterocyclic group (the C2-9 heterocyclic group may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups, tetrazole groups, Ci-10 alkoxycarbonyl groups, Ci-io alkoxy groups, Ci_i0 thioalkyl groups, Ci_i0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, Ci-io alkylcarbonylamino groups and mono- or di- C1-10 alkylamino groups) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
23. The compound according to any one of 19 to 21, wherein R3 is a C2-9 heterocyclic group (the C2-g heterocyclic group is substituted with a substituent selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a sulfamoyl group, a tetrazole group and a Ci-I0 alkoxycarbonyl group and with a substituent selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a sulfamoyl group, a tetrazole group, a Ci-I0 alkoxycarbonyl group, a nitro group, a cyano group, a halogen atom, a Ci-I0 alkyl group, a Ci-I0 alkyl group substituted with one or more fluorine atoms, a sulfamoyl group substituted with a Ci-io alkyl group, a carbamoyl group substituted with a Ci-io alkyl group and a Ci_i0 alkylcarbonylamino group) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
24. The compound according to any one of 19 to 21, wherein R3 is a Ci_io alkyl group or a C2-I0 alkenyl group (the Ci-io alkyl group and the C2-io alkenyl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups, C2-I0 alkenyl groups, Ci-io alkoxy groups, Ci-io thioalkyl groups, Ci-I0 alkylcarbonyl groups, mono- or di-Ci-i0 alkylamino groups, Cx-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups (the Ci-io alkyl groups, the C2-I0 alkenyl groups, the Ci-io alkoxy groups, the C1-I0 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-Ci-10 alkylamino groups, the C1-10 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups and the C1-10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups, tetrazole groups, C1-10 alkoxycarbonyl groups, C1-10 alkoxy groups, C1-10 thioalkyl groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkylcarbonylamino groups and mono- or di- C1-10 alkylamino groups) , nitro group, halogen atoms, hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups and tetrazole groups), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 25. The compound according to any one of 19 to 21, wherein R3 is a C1-10 alkyl group or a C2-10 alkenyl group (the Ci-io alkyl group and the C2-10 alkenyl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups, C2-6 alkenyl groups, C1-10 alkoxy groups, C1-10 thioalkyl groups, C1-10 alkylcarbonyl groups, mono- or di-C1-10 alkylamino groups, C1-10 alkylcarbonyloxyl groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups (the Ci-io alkyl groups, the C2-e alkenyl groups, the Ci_i0 alkoxy groups, the Ci_i0 thioalkyl groups, the C1-X0 alkylcarbonyl groups, the mono- or di-Ci-I0 alkylamino groups, the Ci-I0 alkylcarbonyloxyl groups, the Ci-I0 alkoxycarbonyl groups and the Ci_i0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups and tetrazole groups) , halogen atoms, nitro groups, hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups and tetrazole groups) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 26. The compound according to any one of 19 to 21, wherein R3 is a C2-g heterocyclic group (the C2-9 heterocyclic group is substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, halogen atoms, carboxyl groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, thiocarbamoyl groups, -CH2COOH, -OCH2COOH, -NHCH2COOH, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, -(C=O)COOH,
- CH2 ( C=O) COOH , -NH ( C=O) COOH, -NHSO2NH2 , Ci-10 alkyl groups , Ci-I0 alkyl sulfonyl groups , Ci-I0 alkyl aminosulf onyl groups , Ci-io alkylcarbonyl groups, Ci_i0 alkylaminocarbonyl groups and Ci-io dialkylaminocarbonyl groups (the C1-X0 alkyl groups, the Ci-I0 alkylsulforty1 groups, the C1-K3 alkylaminosulfonyl groups, the Ci-I0 alkylcarbonyl groups, the Ci-io alkylaminocarbonyl groups and the C1-X0 dialkylaminocarbonyl groups may be substituted with one or more substituents selected from the group consisting of phenyl groups, thienyl groups, furyl groups, pyridyl groups, nitro groups, cyano groups, hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups and tetrazole groups) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 27. The thrombopoietin receptor activator according to any one of 1 to 26.
28. A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective, which contains the thrombopoietin receptor activator according to 27, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
29. A platelet increasing agent containing the thrombopoietin receptor activator according to 27, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient. 30 . Medicament containing the compound according to any one of 1 to 26 , a tautomer , prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof , as an active ingredient . The present invention provides pharmaceutical compositions comprising compounds which increase platelets through stimulation of differentiation and proliferation of hematopoietic stem cells , megakaryocytic progenitor cells and megakaryocytes or compounds for therapeut ic angiogenesis or with anti -arteriosclerosis action that stimulate dif ferentiation and prol iferation of vascular endothelial cells and endothel ial progenitor cells .
BRIEF DESCRIPTION OF THE DRAWINGS
Fig . 1 shows the proliferation of UT7/EPO-mpl cells when stimulated by the compound of the present invention (Synthetic Example 4 ) .
Fig . 2 shows the proliferation of UT7/EPO cells when stimulated by the compound of the present invention ( Synthetic Example 4 ) . .
BEST MODE FOR CARRYING OUT THE INVENTION
Now, the present invention will be described in detail .
In the present invention, "n" denotes normal , " i" denotes iso , "s" denotes secondary, "t" denotes tertiary, "c" denotes cyclo, "o" denotes ortho, "m" denotes meta, "p" denotes para, "Ph" denotes phenyl, "Py" denotes pyridyl, "Naphthyl" denotes naphthyl, "Me" denotes methyl, "Et" denotes ethyl, "Pr" denotes propyl, "Bu" denotes butyl and "Ac" denotes acetyl .
First, the terms in the respective substituents R1 to R36 will be explained.
As a halogen atom, a fluorine atom, a chlorine atom, a bromine atom or an iodine atom may be mentioned. A Cχ-3 alkyl group may be linear, branched or a C3 cycloalkyl group, and methyl, ethyl, n-propyl, i-propyl and c-propyl and the like may be mentioned.
A C1S alkyl group may be linear, branched or a C3-5 cycloalkyl group, and in addition to those mentioned above, n-butyl, i-butyl, s-butyl, t-butyl, c-butyl, 1- methyl-c-propyl, 2-methyl-c-propyl, n-pentyl, 1-methyl-n- butyl, 2-methyl-n-butyl, 3-methyl-n-butyl, 1, 1-dimethyl- n-propyl, 1, 2-dimethyl-n-propyl, 2, 2-dimethyl-n-propyl, 1-ethyl-n-propyl, c-pentyl, 1-methyl-c-butyl, 2-methyl-c- butyl, 3-methyl-c-butyl, 1, 2-dimethyl-c-propyl, 2,3- dimethyl-c-propyl, 1-ethyl-c-propyl, 2-ethyl-c-propyl, n- hexyl, 1-methyl-n-pentyl, 2-methyl-n-pentyl, 3-methyl-n- pentyl, 4-methyl-n-pentyl, 1, 1-dimethyl-n-butyl, 1,2- dimethyl-n-butyl, 1,3-dimethyl-n-butyl, 2, 2-dimethyl-n- butyl, 2, 3-dimethyl-n-butyl, 3, 3-dimethyl-n-butyl, 1- ethyl-n-butyl, 2-ethyl-n-butyl, 1,1,2-trimethyl-n-propyl, 1,2, 2-trimethyl-n-propyl, 1-ethyl-1-methyl-n-propyl, 1- ethyl-2-methyl-n-propyl, c-hexyl, 1-methyl-c-pentyl, 2- methyl-c-pentyl, 3-methyl-c-pentyl, 1-ethyl-c-butyl, 2- ethyl-c-butyl, 3-ethyl-c-butyl, 1, 2-dimethyl-c-butyl, 1,3-dimethyl-c-butyl, 2, 2-dimethyl-c-butyl, 2,3-dimethyl- c-butyl, 2,4-dimethyl-c-butyl, 3, 3-dimethyl-c-butyl, 1-n- propyl-c-propyl, 2-n-propyl-c-propyl, 1-i-propyl-c- propyl, 2-i-propyl-c-propyl, 1,2,2-trimethyl-c-propyl, 1, 2, 3-trimethyl-c-propyl, 2,2,3-trimethyl-c-propyl, 1- ethyl-2-methyl-c-propyl, 2-ethyl-1-methyl-c-propyl, 2- ethyl-2-methyl-c-propyl, 2-ethyl-3-methyl-c-propyl and the like may be mentioned.
A Ci-io alkyl group may be linear, branched or a C3-I0 cycloalkyl group, and in addition to those mentioned above, 1-methyl-l-ethyl-n-pentyl, 1-heptyl, 2-heptyl, 1- ethyl-1, 2-dimethyl-n-propyl, l-ethyl-2, 2-dimethyl-n- propyl, 1-octyl, 3-octyl, 4-methyl-3-n-heptyl, 6-methyl- 2-n-heptyl, 2-propyl-1-n-heptyl, 2,4,4-trimethyl-l-n- pentyl, 1-nonyl, 2-nonyl, 2, 6-dimethyl-4-n-heptyl, 3- ethyl-2, 2-dimethyl-3-n-pentyl, 3,5, 5-trimethyl-l-n-hexyl, 1-decyl, 2-decyl, 4-decyl, 3, 7-dimethyl-1-n-octyl, 3,7- dimethyl-3-n-octyl, c-heptyl, c-octyl, 1-methyl-c-hexyl, 2-methyl-c-hexyl, 3-methyl-c-hexyl, 1, 2-dimethyl-c-hexyl, 1-ethyl-c-hexyl, 1-methyl-c-pentyl, 2-methyl-c-pentyl, 3- methyl-c-pentyl and the like may be mentioned. A C2-I0 alkyl group may be linear, branched or a C3-I0 cycloalkyl group, and those mentioned above as Ci-io alkyl groups except for a methyl group may be mentioned. As a C2-6 alkynyl group, ethynyl, 1-propynyl, 2- propynyl, 1-butynyl, 2-butynyl, 3-butynyl, l-methyl-2- propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3- butynyl, 3-methyl-1-butynyl, 1, 1-dimethyl-2-propynyl, 2- ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4- hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, l-methyl-3- pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2- methyl-4-pentynyl, 3-methyl-1-pentynyl, 3-methyl-4- pentynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1,1- dimethyl-2-butynyl, 1, 1-dimethyl-3-butynyl, 1, 2-dimethyl- 3-butynyl, 2,2-dimethyl-3-butynyl, 3, 3-dimethyl-1- butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 1-n- propyl-2-propynyl, 2-ethyl-3-butynyl, l-methyl-l-ethyl-2- propynyl, 1-i-propyl-2-propynyl and the like may be mentioned.
A C2-Io alkynyl group may be linear or branched, and in addition to those mentioned above, 1-methyl-n-hexynyl, 1, 2-dimethyl-n-hexynyl, 1-ethyl-n-hexynyl, 1-n-heptynyl, 2-n-heptynyl, 3-n-heptynyl, 4-n-heptynyl, 1-n-octynyl, 2- n-octynyl, 3-n-octynyl and the like may be mentioned.
A C2-6 alkenyl group may be linear, branched or a C3-6 cycloalkenyl group, and ethenyl, 1-propenyl, 2-propenyl, 1-methyl-1-ethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2- methyl-1-propenyl, 2-methyl-2-propenyl, 1-ethylethenyl, 1-methyl-1-propenyl, 1-methyl-2-propenyl, 1-pentenyl, 2- pentenyl, 3-pentenyl, 4-pentenyl, 1-n-propylethenyl, 1- methyl-1-butenyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 2-ethyl-2-propenyl, 2-methyl-1-butenyl, 2-methyl-2- butenyl, 2-methyl-3-butenyl, 3-methyl-1-butenyl, 3- methyl-2-butenyl, 3-methyl-3-butenyl, 1, 1-dimethyl-2- propenyl, 1-i-propylethenyl, 1,2-dimethyl-1-propenyl,
1, 2-dimethyl-2-propenyl, 1-c-pentenyl, 2-c-pentenyl, 3-c- pentenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5- hexenyl, 1-methyl-1-pentenyl, 1-methyl-2-pentenyl, 1- methyl-3-pentenyl, 1-methyl-4-pentenyl, 1-n-butylethenyl, 2-methyl-1-pentenyl, 2-methyl-2-pentenyl, 2-methyl-3- pentenyl, 2-methyl-4-pentenyl, 2-n-propyl-2-propenyl, 3- methyl-1-pentenyl, 3-methyl-2-pentenyl, 3-methyl-3- pentenyl, 3-methyl-4-pentenyl, 3-ethyl-3-butenyl, 4- methyl-1-pentenyl, 4-methyl-2-pentenyl, 4-methyl-3- pentenyl, 4-methyl-4-pentenyl, 1, 1-dimethyl-2-butenyl, 1, 1-dimethyl-3-butenyl, 1, 2-dimethyl-1-butenyl, 1,2- dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, l-methyl-2- ethyl-2-propenyl, 1-s-butylethenyl, 1, 3-dimethyl-1- butenyl, 1,3-dimethyl-2-butenyl, 1, 3-dimethyl-3-butenyl, 1-i-butylethenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-l- butenyl, 2, 3-dimethyl-2-butenyl, 2, 3-dimethyl-3-butenyl, 2-i-propyl-2-propenyl, 3, 3-dimethyl-1-butenyl, 1-ethyl-l- butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 1-n- propyl-1-propenyl, 1-n-propyl-2-propenyl, 2-ethyl-1- butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2- trimethyl-2-propenyl, 1-t-butylethenyl, 1-methyl-1-ethyl- 2-propenyl, 1-ethyl-2-methyl-1-propenyl, 1-ethyl-2- methyl-2-propenyl, 1-i-propyl-l-propenyl, 1-i-propyl-2- propenyl, l-methyl-2-c-pentenyl, 1-methyl-3-c-pentenyl, 2-methyl-1-c-pentenyl, 2-methyl-2-c-pentenyl, 2-methyl-3- c-pentenyl, 2-methyl-4-c-pentenyl, 2-methyl-5-c-pentenyl, 2-methylene-c-pentyl, 3-methyl-1-c-pentenyl, 3-methyl-2- c-pentenyl, 3-methyl-3-c-pentenyl, 3-methyl-4-c-pentenyl, 3-methyl-5-c-pentenyl, 3-methylene-c-pentyl, 1-c-hexenyl, 2-c-hexenyl, 3-c-hexenyl and the like may be mentioned. A C2-Io alkenyl group may be linear, branched or a C3- io cycloalkenyl group, and in addition to those mentioned above, 1-methyl-n-hexenyl, 1, 2-dimethyl-n-hexenyl, 1- ethyl-n-hexenyl, 1-n-heptenyl, 2-n-heptenyl, 3-n- heptenyl, 4-n-heptenyl, 1-n-octenyl, 2-n-octenyl, 3-n- octenyl, 1-methyl-c-hexenyl, 1, 2-dimethyl-c-hexenyl, 1- ethyl-c-hexenyl, 1-c-heptenyl, 2-c-heptenyl, 3-c- heptenyl, 4-c-heptenyl, 1-c-octenyl, 2-c-octenyl, 3-c- octenyl,4-c-octenyl and the like may be mentioned.
A C2-9 hetercyclic group may be a heteromonocyclic or fused heterobicyclic" group consisting of at least one atom optionally selected from nitrogen atoms, oxygen atoms and sulfur atoms and from 2 to 9 carbon atoms, and specifically, the following structures may be mentioned. -*« -a -Q -Q -Q
Figure imgf000099_0001
Figure imgf000099_0002
A C2-I4 aryl group may be a C6_i4 aryl group containing no hetero atoms as ring constituting atoms or a C2-9 aromatic heterocyclic group, and a C2-g aromatic heterocyclic group may be a 5 to 7-membered C2-6 heteromonocyclic group or 8 to 10-membered C5-9 fused heterobicyclic group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination. As a C6-I4 aryl group containing no hetero atoms, a phenyl group, a 1-indenyl group, a 2-indenyl group, a 3- indenyl group, a 4-indenyl group, a 5-indenyl group, a 6- indenyl group, a 7-indenyl group, an α-naphthyl group, a β-naphthyl group, a 1-tetrahydronaphthyl group, a 2- tetrahydronaphthyl group, a 5-tetrahydronaphthyl group, a 6-tetrahydronaphthyl group, an o-biphenylyl group, a m- biphenylyl group, a p-biphenylyl group, a 1-anthryl group, a 2-anthryl group, a 9-anthryl group, a 1- phenanthryl group, a 2-phenanthryl group, a 3-phenanthryl group, a 4-phenanthryl group, a 9-phenanthryl group or the like may be mentioned.
A 5 to 7-membered C2_6 heteromonocyclic group may be a 2-thienyl group, a 3-thienyl group, a 2-furyl group, a 3- furyl group, a 2-pyranyl group, a 3-pyranyl group, a 4- pyranyl group, a 1-pyrrolyl group, a 2-pyrrolyl group, a 3-pyrrolyl group, a 1-imidazolyl group, a 2-imidazolyl group, a 4-imidazolyl group, a 1-pyrazolyl group, a 3- pyrazolyl group, a 4-pyrazolyl group, a 2-thiazolyl group, a 4-thiazolyl group, a 5-thiazolyl group, a 3- isothiazolyl group, a 4-isothiazolyl group, a 5- isothiazolyl group, a 2-oxazolyl group, a 4-oxazolyl group, a 5-oxazolyl group, a 3-isoxazolyl group, a 4- isoxazolyl group, a 5-isoxazolyl group, a 2-pyridyl group, a 3-pyridyl group, a 4-pyridyl group, a 2- pyrazinyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group, a 5-pyrimidinyl group, a 3-pyridazinyl group, a 4- pyridazinyl group, a 2-1, 3,4-oxadiazolyl group, a 2- 1,3,4-thiadiazolyl group, a 3-1, 2,4-oxadiazolyl group, a 5-1, 2,4-oxadiazolyl group, a 3-1, 2,4-thiadiazolyl group, a 5-1,2,4-thiadiazolyl group, a 3-1, 2, 5-oxadiazolyl group, a 3-1, 2, 5-thiadiazolyl group or the like.
A 8 to 10-membered C5-9 fused heterocyclic group may be a 2-benzofuranyl group, a 3-benzofuranyl group, a 4- benzofuranyl group, a 5-benzofuranyl group, a 6- benzofuranyl group, a 7-benzofuranyl group, a 1- isobenzofuranyl group, a 4-isobenzofuranyl group, a 5- isobenzofuranyl group, a 2-benzothienyl group, a 3- benzothienyl group, a 4-benzothienyl group, a 5- benzothienyl group, a 6-benzothienyl group, a 7- benzothienyl group, a 1-isobenzothienyl group, a 4- isobenzothienyl group, a 5-isobenzothienyl group, a 2- chromenyl group, a 3-chromenyl group, a 4-chromenyl group, a 5-chromenyl group, a 6-chromenyl group, a 7- chromenyl group, a 8-chromenyl group, a 1-indolizinyl group, a 2-indolizinyl group, a 3-indolizinyl group, a 5- indolizinyl group, a 6-indolizinyl group, a 7-indolizinyl group, a 8-indolizinyl group, a 1-isoindolyl group, a 2- isoindolyl group, a 4-isoindolyl group, a 5-isoindolyl group, a 1-indolyl group, a 2-indolyl group, a 3-indolyl group, a 4-indolyl group, a 5-indolyl group, a 6-indolyl group, a 7-indolyl group, 1-indazolyl group, a 2- indazolyl group, a 3-indazolyl group, a 4-indazolyl group, a 5-indazolyl group, a 6-indazolyl group, a 7- indazolyl group, a 1-purinyl group, a 2-purinyl group, a 3-purinyl group, a 6-purinyl group, a 7-purinyl group, a 8-purinyl group, a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group, a 8-quinolyl group, a 1- isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 1- isoquinolyl group, a 8-isoquinolyl group, a 1- phthalazinyl group, a 5-phthalazinyl group, a 6- phthalazinyl group, a 1-2, 7-naphthyridinyl group, a 3- 2, 7-naphthyridinyl group, a 4-2, 7-naphthyridinyl group, a 1-2, 6-naphthyridinyl group, a 3-2, 6-naphthyridinyl group, a 4-2, 6-naphthyridinyl group, a 2-1, 8-naphthyridinyl group, a 3-1, 8-naphthyridinyl group, a 4-1,8- naphthyridinyl group, a 2-1, 7-naphthyridinyl group, a 3- 1, 7-naphthyridinyl group, a 4-1, 7-naphthyridinyl group, a 5-1, 7-naphthyridinyl group, a 6-1, 7-naphthyridinyl group, a 8-1, 7-naphthyridinyl group, 2-1,6-naphthyridinyl group, a 3-1, 6-naphthyridinyl group, a 4-1, 6-naphthyridinyl group, a 5-1,6-naphthyridinyl group, a 7-1,6- naphthyridinyl group, a 8-1, 6-naphthyridinyl group, a 2- 1, 5-naphthyridinyl group, a 3-1, 5-naphthyridinyl group, a 4-1, 5-naphthyridinyl group, a 6-1, 5-naphthyridinyl group, a 7-1, 5-naphthyridinyl group, a 8-1, 5-naphthyridinyl group, a 2-quinoxalinyl group, a 5-quinoxalinyl group, a 6-quinoxalinyl group, a 2-quinazolinyl group, a 4- quinazolinyl group, a 5-quinazolinyl group, a 6- quinazolinyl group, a 7-quinazolinyl group, a 8- quinazolinyl group, a 3-cinnolinyl group, a 4-cinnolinyl group, a 5-cinnolinyl group, a 6-cinnolinyl group, a 7- cinnolinyl group, a 8-cinnolinyl group, a 2-pterdinyl group, a 4-pterdinyl group, a 6-pterdinyl group, a 7- pterdinyl group or the like.
A C2-i4 aryloxy group may be a C6-i4 aryloxy group containing no hetero atoms as ring constituting atoms or a C2-9 aromatic heterocyclic oxy group, and a C2-9 aromatic heterocyclic oxy group may be a 5 to 7-membered C2-6 heteromonocyclic oxy group or 8 to 10-membered C5-9 fused heterobicyclic oxy group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.
As a C6.i4 aryloxy group containing no hetero atoms, a phenyloxy group, a 1-indenyloxy group, a 2-indenyloxy group, a 3-indenyloxy group, a 4-indenyloxy group, a 5- indenyloxy group, a 6-indenyloxy group, a 7-indenyloxy group, an α-naphthyloxy group, a β-naphthyloxy group, a 1-tetrahydronaphthyloxy group, a 2-tetrahydronaphthyloxy group, a 5-tetrahydronaphthyloxy group, a 6- tetrahydronaphthyloxy group, an o-biphenylyloxy group, a m-biphenylyloxy group, a p-biphenylyloxy group, a 1- anthryloxy group, a 2-anthryloxy group, a 9-anthryloxy group, a 1-phenanthryloxy group, a 2-phenanthryloxy group, a 3-phenanthryloxy group, a 4-phenanthryloxy group, a 9-phenanthryloxy group or the like may be mentioned.
A 5 to 7-membered C2-β heteromonocyclic oxy group may be a 2-thienyloxy group, a 3-thienyloxy group, a 2- furyloxy group, a 3-furyloxy group, a 2-pyranyloxy group, a 3-pyranyloxy group, a 4-pyranyloxy group, a 1- pyrrolyloxy group, a 2-pyrrolyloxy group, a 3-pyrrolyloxy group, a 1-imidazolyloxy group, a 2-iτnidazolyloxy group, a 4-imidazolyloxy group, a 1-pyrazolyloxy group, a 3- pyrazolyloxy group, a 4-pyrazolyloxy group, a 2- thiazolyloxy group, a 4-thiazolyloxy group, a 5- thiazolyloxy group, a 3-isothiazolyloxy group, a 4- isothiazolyloxy group, a 5-isothiazolyloxy group, a 2- oxazolyloxy group, a 4-oxazolyloxy group, a 5-oxazolyloxy group, a 3-isoxazolyloxy group, a 4-isoxazolyloxy group, a 5-isoxazolyloxy group, a 2-pyridyloxy group, a 3- pyridyloxy group, a 4-pyridyloxy group, a 2-pyrazinyloxy group, a 2-pyrimidinyloxy group, a 4-pyrimidinyloxy group, a 5-pyrimidinyloxy group, a 3-pyridazinyloxy group, a 4-pyridazinyloxy group, a 2-1,3,4-oxadiazolyloxy group, a 2-1, 3,4-thiadiazolyloxy group, a 3-1,2,4- oxadiazolyloxy group, a 5-1, 2,4-oxadiazolyloxy group, a 3-1, 2,4-thiadiazolyloxy group, a 5-1, 2,4-thiadiazolyloxy group, a 3-1, 2, 5-oxadiazolyloxy group, a 3-1,2,5- thiadiazolyloxy group or the like.
A 8 to 10-membered C5-9 fused heterobicyclic oxy group may be a 2-benzofuranyloxy group, a 3- benzofuranyloxy group, a 4-benzofuranyloxy group, a 5- benzofuranyloxy group, a 6-benzofuranyloxy group, a 7- benzofuranyloxy group, a 1-isobenzofuranyloxy group, a 4- isobenzofuranyloxy group, a 5-isobenzofuranyloxy group, a 2-benzothienyloxy group, a 3-benzothienyloxy group, a 4- benzothienyloxy group, a 5-benzothienyloxy group, a 6- benzothienyloxy group, a 7-benzothienyloxy group, a 1- isobenzothienyloxy group, a 4-isobenzothienyloxy group, a 5-isobenzothienyloxy group, a 2-chromenyloxy group, a 3- chromenyloxy group, a 4-chromenyloxy group, a 5- chromenyloxy group, a β-chromenyloxy group, a 7- chromenyloxy group, a 8-chromenyloxy group, a 1- indolizinyloxy group, a 2-indolizinyloxy group, a 3- indolizinyloxy group, a 5-indolizinyloxy group, a 6- indolizinyloxy group, a 7-indolizinyloxy group, a 8- indolizinyloxy group, a 1-isoindolyloxy group, a 2- isoindolyloxy group, a 4-isoindolyloxy group, a 5- isoindolyloxy group, a 1-indolyloxy group, a 2-indolyloxy group, a 3-indolyloxy group, a 4-indolyloxy group, a 5- indolyloxy group, a 6-indolyloxy group, a 7-indolyloxy group, 1-indazolyloxy group, a 2-indazolyloxy group, a 3- indazolyloxy group, a 4-indazolyloxy group, a 5- indazolyloxy group, a 6-indazolyloxy group, a 7- indazolyloxy group, a 1-purinyloxy group, a 2-purinyloxy group, a 3-purinyloxy group, a 6-purinylόxy group, a 7- purinyloxy group, a 8-purinyloxy group, a 2-quinolyloxy group, a 3-quinolyloxy group, a 4-quinolyloxy group, a 5- quinolyloxy group, a 6-quinolyloxy group, a 7-quinolyloxy group, a 8-quinolyloxy group, a 1-isoquinolyloxy group, a 3-isoquinolyloxy group, a 4-isoquinolyloxy group, a 5- isoquinolyloxy group, a 6-isoquinolyloxy group, a 7- isoquinolyloxy group, a 8-isoquinolyloxy group, a 1- phthalazinyloxy group, a 5-phthalazinyloxy group, a 6- phthalazinyloxy group, a 1-2, 7-naphthyridinyloxy group, a 3-2, 7-naphthyridinyloxy group, a 4-2, 7-naphthyridinyloxy group, a 1-2, 6-naphthyridinyloxy group, a 3-2,6- naphthyridinyloxy group, a 4-2, 6-naphthyridinyloxy group, a 2-1, 8-naphthyridinyloxy group, a 3-1,8- naphthyridinyloxy group, a 4-1, 8-naphthyridinyloxy group, a 2-1, 7-naphthyridinyloxy group, a 3-1,7- naphthyridinyloxy group, a 4-1, 7-naphthyridinyloxy group, a 5-1, 7-naphthyridinyloxy group, a 6-1,7- naphthyridinyloxy group, a 8-1, 7-naphthyridinyloxy group, 2-1, 6-naphthyridinyloxy group, a 3-1, 6-naphthyridinyloxy group, a 4-1, 6-naphthyridinyloxy group, a 5-1,6- naphthyridinyloxy group, a 7-1, 6-naphthyridinyloxy group, a 8-1, 6-naphthyridinyloxy group, a 2-1,5- naphthyridinyloxy group, a 3-1, 5-naphthyridinyloxy group, a 4-1, 5-naphthyridinyloxy group, a 6-1,5- naphthyridinyloxy group, a 7-1, 5-naphthyridinyloxy group, a 8-1, 5-naphthyridinyloxy group, a 2-quinoxalinyloxy group, a 5-quinoxalinyloxy group, a 6-quinoxalinyloxy group, a 2-quinazolinyloxy group, a 4-quinazolinyloxy group, a 5-quinazolinyloxy group, a 6-quinazolinyloxy group, a 7-quinazolinyloxy group, a 8-quinazolinyloxy group, a 3-cinnolinyloxy group, a 4-cinnolinyloxy group, a 5-cinnolinyloxy group, a 6-cinnolinyloxy group, a 7- cinnolinyloxy group, a 8-cinnolinyloxy group, a 2- pterdinyloxy group, a 4-pterdinyloxy group, a 6- pterdinyloxy group, a 7-pterdinyloxy group or the like. A Ci-6 alkylcarbonyl group may linear, branched or a C3-6 cycloalkylcarbonyl group, and be methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, i-propylcarbonyl, c- propylcarbonyl, n-butylcarbonyl, i-butylcarbonyl, s- butylcarbonyl, t-butylcarbonyl, c-butylcarbonyl, 1- methyl-c-propylcarbonyl, 2-methyl-c-propylcarbonyl, n- pentylcarbonyl, 1-methyl-n-butylcarbonyl, 2-methyl~n~ butylcarbonyl, 3-methyl-n-butylcarbonyl, 1, 1-dimethyl-n- propylcarbonyl, 1, 2-dimethyl-n-propylcarbonyl, 2,2- dimethyl-n-propylcarbonyl, 1-ethyl-n-propylcarbonyl, c- pentylcarbonyl, 1-methyl-c-butylcarbonyl, 2-methyl-c- butylcarbonyl, 3-methyl-c-butylcarbonyl, 1, 2-dimethyl-c- propylcarbonyl, 2, 3-dimethyl-c-propylcarbonyl, 1-ethyl-c- propylcarbonyl, 2-ethyl-c-propylcarbonyl, n- hexylcarbonyl, 1-methyl-n-pentylcarbonyl, 2-methyl-n- pentylcarbonyl, .3-methyl-n-pentylcarbonyl, 4-methyl-n- pentylcarbonyl, 1, 1-dimethyl-n-butylcarbonyl, 1,2- dimethyl-n-butylcarbonyl, 1, 3-dimethyl-n-butylcarbonyl, 2, 2-dimethyl-n-butylcarbonyl, 2,3-dimethyl-n- butylcarbonyl, 3, 3-dimethyl-n-butylcarbonyl, 1-ethyl-n- butylcarbonyl, 2-ethyl-n-butylcarbonyl, 1, 1,2-trimethyl- n-propylcarbonyl, 1, 2, 2-trimethyl-n-propylcarbonyl, 1- ethyl-1-methyl-n-propylcarbonyl, 1-ethyl-2-methyl-n- propylcarbonyl, c-hexylcarbonyl, 1-methyl-c- pentylcarbonyl, 2-methyl-c-pentylcarbonyl, 3-methyl-c- pentylcarbonyl, 1-ethyl-c-butylcarbonyl, 2-ethyl-c- butylcarbonyl, 3-ethyl-c-butylcarbonyl, 1, 2-dimethyl-c- butylcarbonyl, 1,3-dimethyl-c-butylcarbonyl, 2,2- dimethyl-c-butylcarbonyl, 2, 3-dimethyl-c-butylcarbonyl, 2,4-dimethyl-c-butylcarbonyl, 3, 3-dimethyl-c- butylcarbonyl, 1-n-propyl-c-propylcarbonyl, 2-n-propyl-c- propylcarbonyl, 1-i-propyl-c-propylcarbonyl, 2-i-propyl- c-propylcarbonyl, 1,2, 2-trimethyl-c-propylcarbonyl, 1, 2, 3-trimethyl-c-propylcarbonyl, 2, 2, 3-trimethyl-c- propylcarbonyl, l-ethyl-2-methyl-c-propylcarbonyl, 2- ethyl-1-methyl-c-propylcarbonyl, 2-ethyl-2-methyl-c- propylcarbonyl, 2-ethyl-3-methyl-c-propylcarbonyl or the like may be mentioned. A C1-I0 alkylcarbonyl may be linear, branched or a
C3-10 cycloalkylcarbonyl group, and in addition to those mentioned above, 1-methyl-l-ethyl-n-pentylcarbonyl, 1- heptylcarbonyl, 2-heptylcarbonyl, 1-ethyl-1, 2-dimethyl-n- propylcarbonyl, 1-ethyl-2,2-dimethyl-n-propylcarbonyl, 1- octylcarbonyl, 3-octylcarbonyl, 4-methyl-3-n- heptylcarbonyl, 6-methyl-2-n-heptylcarbonyl, 2-propyl-1- n-heptylcarbonyl, 2,4, 4-trimethyl-l-n-pentylcarbonyl, 1- nonylcarbonyl, 2-nonylcarbonyl, 2, 6-dimethyl-4-n- heptylcarbonyl, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonyl, 3, 5, 5-trimethyl-l-n-hexylcarbonyl, 1-decylcarbonyl, 2- decylcarbonyl, 4-decylcarbonyl, 3, 7-dimethyl-1-n- octylcarbonyl, 3, 7-dimethyl-3-n-octylcarbonyl or the like may be mentioned.
A Ci-6 alkylaminosulfonyl group may be linear, branched or a C3-6 cycloalkylaminosulfonyl group, and methylaminosulfonyl, ethylaminosulfonyl, n- propylaminosulfonyl, i-propylaminosulfonyl, c- propylaminosulfonyl, n-butylaminosulfonyl, i- butylaminosulfonyl, s-butylaminosulfonyl, t- butylaminosulfonyl, c-butylaminosulfonyl, 1-methyl-c- propylaminosulfonyl, 2-methyl-c-propylaminosulfonyl, n- pentylaminosulfonyl, 1-methyl-n-butylaminosulfonyl, 2- methyl-n-butylaminosulfonyl, 3-methyl-n- butylaminosulfonyl, 1,1-dimethyl-n-propylaminosulfonyl, 1, 2-dimethyln-propylaminosulfonyl, 2, 2-dimethyln- propylaminosulfonyl, 1-ethyl-n-propylaminosulfonyl, c- pentylaminosulfonyl, 1-methyl-c-butylaminosulfonyl, 2- methyl-c-butylaminosulfonyl, 3-methyl-c- butylaminosulfonyl, 1,2-dimethyl-c-propylaminosulfonyl, 2, 3-dimethyl-c-propylaminosulfonyl, 1-ethyl-c- propylaminosulfonyl, 2-ethyl-c-propylaminosulfonyl, n- hexylaminosulfonyl, 1-methyl-n-pentylaminosulfonyl, 2- methyl-n-pentylaminosulfonyl, 3-methyl-n- pentylaminosulfonyl, 4-methyl-n-pentylaminosulfonyl, 1,1- dimethyl-n-butylaminosufonyl, 1,2-dimethyl-n- butylaminosufonyl, 1, 3-dimethyl-n-butylaminosufonyl, 2,2- dimethyl-n-butylamiriosufonyl, 2, 3-dimethyl-n- butylaminosufonyl, 3, 3-dimethyl-n-butylaminosufonyl, 1- ethyl-n-butylaminosufonyl, 2-ethyl-n-butylaminosufonyl, 1,1, 2-trimethyl-n-propylaminosulfonyl, 1,2,2-trimethyl-n- propylaminosulfonyl, 1-ethyl-1-methyl-n- propylaminosulfonyl, 1-ethyl-2-methyl-n- propylaminosulfonyl, c-hexylaminosulfonyl, 1-methyl-c- pentylaminosulfonyl, 2-methyl-c-pentylaminosulfonyl, 3- methyl-c-pentylaminosulfonyl, 1-ethyl-c- butylaminosulfonyl, 2-ethyl-c-butylaminosulfonyl, 3- ethyl-c-butylaminosulfonyl, 1, 2-dimethyl-c- butylaminosulfonyl, 1, 3-dimethyl-c-butylaminosulfonyl, 2, 2-dimethyl-c-butylaminosulfonyl, 2, 3-dimethyl-c- butylaminosulfonyl, 2,4-dimethyl-c-butylaminosulfonyl, 3, 3-dimethyl-c-butylaminosulfonyl, 1-n-propyl-c- propylaminosulfonyl, 2-n-propyl-c-propylaminosulfonyl, 1- i-propyl-c-propylaminosulfonyl, 2-i-propyl-c- propylaminosulfonyl, 1, 2, 2-trimethyl-c- propylaminosulfonyl, 1,2, 3-trimethyl-c- propylaminosulfonyl, 2,2, 3-trimethyl-c- propylaminosulfonyl, 1-ethyl-2-methyl-c- propylaminosulfonyl, 2-ethyl-1-methyl-c- propylaminosulfonyl, 2-ethyl-2-methyl-c- propylaminosulfonyl, 2-ethyl-3-methyl-c- propylaminosulfonyl or the like may be mentioned. A Ci-io alkylaminosulfonyl group may be linear, branched or a C3-I0 cycloalkylsulfonylamino group, and in addition to those mentioned above, 1-methyl-1-ethyl-n- pentylaminosulfonyl, 1-heptylaminosulfonyl, 2- heptylaminosulfonyl, 1-ethyl-1, 2-dimethyl-n- propylaminosulfonyl, l-ethyl-2, 2-dimethyl-n- propylaminosulfonyl, 1-octylaminosulfonyl, 3- octylaminosulfonyl, 4-methyl-3-n-heptylaminosulfonyl, 6- methyl-2-n-heptylaminosulfonyl, 2-propyl-1-n- heptylaminosulfonyl, 2,4,4-trimethyl-l-n- pentylaminosulfonyl, 1-nonylaminosulfonyl, 2- nonylaminosulfonyl, 2, 6-dimethyl-4-n-heptylaminosulfonyl, 3-ethyl-2, 2-dimethyl-3-n-pentylaminosulfonyl, 3,5,5- trimethl-1-n-hexylaminosulfonyl, 1-decylaminosulfonyl, 2- decylaminosulfonyl, 4-decylaminosulfonyl, 3, 7-dimetyl-l- n-octylaminosulfonyl, 3, 7-dimetyl-3-n-octylaminosulfonyl, c-heptylaminosulfonyl, c-octylaminosulfonyl, 1-methyl-c- hexylaminosulfonyl, 2-methyl-c-hexylaminosulfonyl, 3- methyl-c-hexylaminosulfonyl, 1,2-dimethyl-c- hexylaminosulfonyl, 1-ethyl-c-hexylaminosulfonyl, 1- methyl-c-pentylaminosulfonyl, 2-methyl-c- pentylaminosulfonyl, 3-methyl-c-pentylaminosulfonyl or the like may be mentioned.
A Ci-6 alkylsulfonyl group may be linear, branched or a C3-6 cycloalkylsulfonyl group, and methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, i-propylsulfonyl, c- propylsulfonyl, n-butylsulfonyl, i-butylsulfonyl, s- butylsulfonyl, t-butylsulfonyl, c-butylsulfonyl, 1- methyl-c-propylsulfonyl, 2-methyl-c-propylsulfonyl, n- pentylsulfonyl, 1-methyl-n-butylsulfonyl, 2-methyl-n- butylsulfonyl, 3-methyl.-n-butylsulfonyl, 1, 1-dimethyl-n- propylsulfonyl, 1,2-dimethyl-n-propylsulfonyl, 2,2- dimethyl-n-propylsulfonyl, 1-ethyl-n-propylsulfonyl, c- pentylsulfonyl, 1-methyl-c-butylsulfonyl, 2-methyl-c- butylsulfonyl, 3-methyl-c-butylsulfonyl, 1, 2-dimethyl-c- propylsulfonyl, 2, 3-dimethyl-c-propylsulfonyl, 1-ethyl-c- propylsulfonyl, 2-ethyl-c-propylsulfonyl,n-hexylsulfonyl, 1-methyl-n-pentylsulfonyl, 2-methyl-n-pentylsulfonyl, 3- methyl-n-pentylsulfonyl, 4-methyl-n-pentylsulfonyl, 1,1- dimethyl-n-butylsulfonyl, 1, 2-dimethyl-n-butylsulfonyl, 1, 3-dimethyl-n-butylsulfonyl, 2, 2-dimethyl-n- butylsulfonyl, 2, 3-dimethyl-n-butylsulfonyl, 3,3- dimethyl-n-butylsulfonyl, 1-ethyl-n-butylsulfonyl, 2- ethyl-n-butylsulfonyl, 1,1, 2-trimethyl-n-propylsulfonyl, 1,2, 2-trimethyl-n-propylsulfonyl, 1-ethyl-l-methyl-n- propylsulfonyl, 1-ethyl-2-methyl-n-propylsulfonyl, c- hexylsulfonyl, 1-methyl-c-pentylsulfonyl, 2-methyl-c- pentylsulfonyl, 3-methyl-c-pentylsulfonyl, 1-ethyl-c- butylsulfonyl, 2-ethyl-c-butylsulfonyl, 3-ethyl-c- butylsulfonyl, 1, 2-dimethyl-c-butylsulfonyl, 1,3- dimethyl-c-butylsulfonyl, 2,2-dimethyl-c-butylsulfonyl, 2, 3-dimethyl-c-butylsulfonyl, 2,4-dimethyl~c- butylsulfonyl, 3, 3-dimethyl-c-butylsulfonyl, 1-n-propyl- c-propylsulfonyl, 2-n-propyl-c-propylsulfonyl, 1-i- propyl-c-propylsulfonyl, 2-i-propyl-c-propylsulfonyl, 1,2, 2-trimethyl-c-propylsulfonyl, 1,2, 3-trimethyl-c- propylsulfonyl, 2, 2, 3,-trimethyl-c-propylsulfonyl, 1- ethyl-2-methyl-c-propylsulfonyl, 2-ethyl-1-methyl-c- propylsulfonyl, 2-ethyl-2-methyl-c-propylsulfonyl, 2- ethyl-3-methyl-c-propylsulfonyl or the like may be mentioned. A C1-X0 alkylsulfonyl group may be linear, branched or a C3-10 cycloalkylsulfonyl group, and in addition to those mentioned above, 1-methyl-l-ethyl-n-pentylsulfonyl, 1- heptylsulfonyl, 2-heptylsulfonyl, 1-ethyl-l,2-dimethyl-n- propylsulfonyl, l-ethyl-2,2-dimethyl-n-propylsulfonyl, 1- octylsulfonyl, 3-octylsulfonyl, 4-methyl-3-n- heptylsulfonyl, 6-methyl-2-n-heptylsulfonyl, 2-propyl-l- n-n-heptylsulfonyl, 2, 4,4-trimethyl-l-n-pentylsulfonyl, 1-nonylsulfonyl, 2-nonylsulfonyl, 2, 6-dimetyl-4~n- heptylsulfonyl, 3-ethyl-2,2-dimethyl-3-n-pentylsulfonyl, 3, 5, 5-trimethyl-l-n-hexylsulfonyl, 1-decylsulfonyl, 2- decylsulfonyl, 4-decylsulfonyl, 3, 7-dimethyl-1-n- octylsulfonyl, 3 , 7-dimethyl-3-n-octylsulfonyl, c- heptylsulfonyl, c-octylsulfonyl, 1-methyl-c- hexylsulfonyl, 2-methyl-c-hexylsulfonyl, 3-methyl-c- hexylsulfonyl, 1, 2-dimetyl-c-hexylsulfonyl, 1-ethyl-c- hexylsulfonyl, 1-methyl-c-pentylsulfonyl, 2-methyl-c- pentylsulfonyl, 3-methyl-c-pentylsulfonyl or the like may be mentioned.
A Ci-io alkoxy group may be linear, branched or a C3-I0 cycloalkoxy group, and methoxy, ethoxy, n-propoxy, i- propoxy, c-propoxy, n-butoxy, i-butoxy, s-butoxy, t- butoxy, c-butoxy, 1-methyl-c-propoxy, 2-methyl-c-propoxy, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy, 3- methyl-n-butoxy, 1, 1-dimethyl-n-propoxy, 1,2-dimethyl-n- propoxy, 2,2-dimethyl-n-propoxy, 1-ethyl-n-propoxy, c- pentyloxy, 1-methyl-c-butoxy, 2-methyl-c-butoxy, 3- methyl-c-butoxy, 1, 2-dimethyl-c-propoxy, 2,3-dimethyl-c- propoxy, 1-ethyl-c-propoxy, 2-ethyl-c-propoxy, n- hexyloxy, 1-methyl-n-pentyloxy, 2-methyl-n-pentyloxy, 3- methyl-n-pentyloxy, 4-methyl-n-pentyloxy, 1, 1-dimethyl-n- butoxy, 1, 2-dimethyl-n-butoxy, 1, 3-dimethyl-n-butoxy, 2, 2-dimethyl-n-butoxy, 2,3-dimethyl-n-butoxy, 3,3- dimethyl-n-butoxy, 1-ethyl-n-butoxy, 2-ethyl-n-butoxy, 1, 1, 2-trimethyl-n-propoxy, 1, 2, 2-trimethyl-n-propoxy, 1- ethyl-1-methyl-n-propoxy, 1-ethyl-2-methyl-n-propoxy, c- hexyloxy, 1-methyl-c-pentyloxy, 2-methyl-c-pentyloxy, 3- methyl-c-pentyloxy, 1-ethyl-c-butoxy, 2-ethyl-c-butoxy, 3-ethyl-c-butoxy, 1, 2-dimethyl-c-butoxy, 1, 3-dimethyl-c- butoxy, 2, 2-dimethyl-c-butoxy, 2, 3-dimethyl-c-butoxy,
2,4-dimethyl-c-butoxy, 3,3-dimethyl-c-butoxy, 1-n-propyl- c-propoxy, 2-n-propyl-c-propoxy, 1-i-propyl-c-propoxy, 2- i-propyl-c-propoxy, 1, 2, 2-trimethyl-c-propoxy, 1,2,3- trimethyl-c-propoxy, 2, 2,3-trimethyl-c-propoxy, 1-ethyl- 2-methyl-c-propoxy, 2-ethyl-1-methyl-c-propoxy, 2-ethyl- 2-methyl-c-propoxy, 2-ethyl-3-methyl-c-propoxy, 1-methyl- 1-ethyl-n-pentyloxy, 1-heptyloxy, 2-heptyloxy, 1-ethyl- 1, 2-dimethyl-n-propyloxy, 1-ethyl-2, 2-dimethyl-n- propyloxy, 1-octyloxy, 3-octyloxy, 4-methyl-3-n~ heptyloxy, 6-methyl-2-n-heptyloxy, 2-propyl-l-n- heptyloxy, 2, 4,4-trimethyl-l-n-pentyloxy, 1-nonyloxy, 2- nonyloxy, 2, 6-dimethyl-4-n-heptyloxy, 3-ethyl-2,2- dimethyl-3-n-pentyloxy, 3, 5, 5-trimethyl-l-n-hexyloxy, 1- decyloxy, 2-decyloxy, 4-decyloxy, 3, 7-dimethyl-1-n- octyloxy, 3, 7-dimethyl-3-n-octyloxy or the like may be mentioned.
A Ci-xo thioalkyl group may linear, branched or a C3-I0 cyclothioalkyl group, and be methylthio, ethylthio, n- propylthio, i-propylthio, c-propylthio, n-butylthio, i- butylthio, s-butylthio, t-butylthio, c-butylthio, 1- methyl-c-propylthio, 2-methyl-c-propylthio, n-pentylthio, 1-methyl-n-butylthio, 2-methyl-n-butylthio, 3-methyl-n- butylthio, 1, 1-dimethyl-n-propylthio, 1,2-dimethyl-n- propylthio, 2, 2-dimethyl-n-propylthio, 1-ethyl-n- propylthio, c-pentylthio, 1-methyl-c-butylthio, 2-methyl- c-butylthio, 3-methyl-c-butylthio, 1, 2-dimethyl-c- propylthio, 2, 3-dimethyl-c-propylthio, 1-ethyl-c- propylthio, 2-ethyl-c-propylthio, n-hexylthio, 1-methyl- n-pentylthio, 2-methyl-n-pentylthio, 3-methyl-n- pentylthio, 4-methyl-n-pentylthio, 1, 1-dimethyl-n- butylthio, 1, 2-dimethyl-n-butylthio, 1,3-dimethyl-n- butylthio, 2, 2-dimethyl-n-butylthio, 2,3-dimethyl-n- butylthio, 3, 3-dimethyl-n-butylthio, 1-ethyl-n-butylthio, 2-ethyl-n-butylthio, 1, 1, 2-trimethyl-n-propylthio, 1,2,2- trimethyl-n-propylthio, 1-ethyl-l-methyl-n-propylthio, 1- ethyl-2-methyl-n-propylthio, c-hexylthio, 1-methyl-c- pentylthio, 2-methyl-c-pentylthio, 3-methyl-c-pentylthio, 1-ethyl-c-butylthio, 2-ethyl-c-butylthio, 3-ethyl-c- butylthio, 1, 2-dimethyl-c-butylthio, 1,3-dimethyl-c- butylthio, 2, 2-dimethyl-c-butylthio, 2,3-dimethyl-c- butylthio, 2,4-dimethyl-c-butylthio, 3,3-dimethyl-c- butylthio, 1-n-propyl-c-propylthio, 2-n-propyl-c- propylthio, 1-i-propyl-c-propylthio, 2-i-propyl-c- propylthio, 1, 2, 2-trimethyl-c-propylthio, 1,2,3- trimethyl-c-propylthio, 2, 2, 3-trimethyl-c-propylthio, 1- ethyl-2-methyl-c-propylthio, 2-ethyl-1-methyl-c- propylthio, 2-ethyl-2-methyl-c-propylthio, 2-ethyl-3- methyl-c-propylthio, 1-methyl-1-ethyl-n-pentylthio, 1- heptylthio, 2-heptylthio, 1-ethyl-1,2-dimethyl-n- propylthio, l-ethyl-2,2-dimethyl-n-propylthio, 1- octylthio, 3-octylthio, 4-methyl-3-n-heptylthio, 6- methyl-2-n-heptylthio, 2-propyl-1-n-heptylthio, 2,4,4- trimethyl-1-n-pentylthio, 1-nonylthio, 2-nonylthio, 2,6- dimethyl-4-n-heptylthio, 3-ethyl-2, 2-dimethyl-3-n- pentylthio, 3, 5, 5-trimethyl-l-n-hexylthio, 1-decylthio, 2-decylthio, 4-decylthio, 3, 7-dimethyl-l-n-octylthio, 3, 7-dimethyl-3-n-octylthio or the like may be mentioned. A Ci-6 alkoxycarbonyl group may be linear, branched or a C3-(S cycloalkoxycarbonyl group, and methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, c- propoxylcarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, s- butoxycarbonyl, t-butoxycarbonyl, c-butoxycarbonyl, 1- methyl-c-propoxycarbonyl, 2-methyl-c-propoxycarbonyl, n- pentyloxycarbonyl, 1-methyl-n-butoxycarbonyl, 2-methyl-n- butoxycarbonyl, 3-methyl-n-butoxycarbonyl, 1, 1-dimethyl- n-propoxycarbonyl, 1, 2-dimethyl-n-propoxycarbonyl, 2,2- dimethyl-n-propoxycarbonyl, 1-ethyl-n-propoxycarbonyl, c- pentyloxycarbonyl, 1-methyl-c-butoxycarbonyl, 2-methyl-c- butoxycarbonyl, 3-methyl-c-butoxycarbonyl, 1, 2-dimethyl- c-propoxycarbonyl, 2, 3-dimethyl-c-propoxycarbonyl, 1- ethyl-c-propoxycarbonyl, 2-ethyl-c-propoxycarbonyl, n- hexyloxycarbonyl, 1-methyl-n-pentyloxycarbonyl, 2-methyl- n-pentyloxycarbonyl, 3-methyl-n-pentyloxycarbonyl, 4- methyl-n-pentyloxycarbonyl, 1, 1-dimethyl-n- butoxycarbonyl, 1,2-dimethyl-n-butoxycarbonyl, 1,3- dimethyl-n-butoxycarbonyl, 2, 2-dimethyl-n-butoxycarbonyl, 2, 3-dimethyl-n-butoxycarbonyl, 3,3-dimethyl-n- butoxycarbonyl, 1-ethyl-n-butoxycarbonyl, 2-ethyl-n- butoxycarbonyl, 1, 1, 2-trimethyl-n-propoxycarbonyl, 1,2,2- trimethyl-n-propoxycarbonyl, 1-ethyl-1-methyl-n- propoxycarbonyl, 1-ethyl-2-methyl-n-propoxycarbonyl, c- hexyloxycarbonyl, 1-methyl-c-pentyloxycarbonyl, 2-methyl- c-pentyloxycarbonyl, 3-methyl-c-pentyloxycarbonyl, 1- ethyl-c-butoxycarbonyl, 2-ethyl-c-butoxycarbonyl, 3- ethyl-c-butoxycarbonyl, 1, 2-dimethyl-c-butoxycarbonyl, 1,3-dimethyl-c-butoxycarbonyl, 2,2-dimethyl-c- butoxycarbonyl, 2,3-dimethyl-c-butoxycarbonyl, 2,4- dimethyl-c-butoxycarbonyl, 3, 3-dimethyl-c-butoxycarbonyl, 1-n-propyl-c-propoxycarbonyl, 2-n-propyl-c- propoxycarbonyl, 1-i-propyl-c-propoxycarbonyl, 2-i- propyl-c-propoxycarbonyl, 1, 2, 2-trimethyl-c- propoxycarbonyl, 1,2,3-trimethyl-c-propoxycarbonyl, 2,2,3-trimethyl-c-propoxycarbonyl, 1-ethyl-2-methyl-c- propoxycarbonyl, 2-ethyl-1-methyl-c-propoxycarbonyl, 2- ethyl-2-methyl-c-propoxycarbonyl, 2-ethyl-3-methyl-c- propoxycarbonyl or the like may be mentioned.
A Ci-io alkoxycarbonyl group may be linear, branched or a C3-10 cycloalkoxycarbonyl group, and in addition to those mentioned above, 1-methyl-l-ethyl-n- pentyloxycarbonyl, 1-heptyloxycarbonyl, 2- heptyloxycarbonyl, 1-ethyl-l,2-dimethyl-n- propyloxycarbonyl, l-ethyl-2,2-dimethyl-n- propyloxycarbonyl, 1-octyloxycarbonyl, 3- octyloxycarbonyl, 4-methyl-3-n-heptyloxycarbonyl, 6- methyl-2-n-heptyloxycarbonyl, 2-propyl-1-n- heptyloxycarbonyl, 2,4,4-trimethyl-l-n-pentyloxycarbonyl, 1-nonyloxycarbonyl, 2-nonyloxycarbonyl, 2, 6-dimethyl-4-n- heptyloxycarbonyl, 3-ethyl-2,2-dimethyl-3-n- pentyloxycarbonyl, 3,5, 5-trimethyl-l-n-hexyloxycarbonyl, 1-decyloxycarbonyl, 2-decyloxycarbonyl, 4- decyloxycarbonyl, 3, 7-dimethyl-l-n-octyloxycarbonyl, 3,7- dimethyl-3-n-octyloxycarbonyl or the like may be mentioned.
A Ci-io alkylcarbonyloxy group may be linear, branched or a C3-10 cycloalkylcarbonyloxy group, and methylcarbonyloxy, ethylcarbonyloxy, n-propylcarbonyloxy, i-propylcarbonyloxy, c-propylcarbonyloxy, n- butylcarbonyloxy, i-butylcarbonyl'oxy, s-butylcarbonyloxy, t-butylcarbonyloxy, c-butylcarbonyloxy, 1-methyl-c- propylcarbonyloxy, 2-methyl-c-propylcarbonyloxy, n- pentylcarbonyloxy, 1-methyl-n-butylcarbonyloxy, 2-methyl- n-butylcarbonyloxy, 3-methyl-n-butylcarbonyloxy, 1,1- dimethyl-n-propylcarbonyloxy, 1, 2-dimethyl-n- propylcarbonyloxy, 2, 2-dimethyl-n-propylcarbonyloxy, 1- ethyl-n-propylcarbonyloxy, c-pentylcarbonyloxy, 1-methyl- c-butylcarbonyloxy, 2-methyl-c-butylcarbonyloxy, 3- methyl-c-butylcarbonyloxy, 1, 2-dimethyl-c- propylcarbonyloxy, 2, 3-dimethyl-c-propylcarbonyloxy, 1- ethyl-c-propylcarbonyloxy, 2-ethyl-c-propylcarbonyloxy, n-hexylcarbonyloxy, 1-methyl-n-pentylcarbonyloxy, 2- methyl-n-pentylcarbonyloxy, 3-methyl-n-pentylcarbonyloxy, 4-methyl-n-pentylcarbonyloxy, 1, 1-dimethyl-n- butylcarbonyloxy, 1, 2-dimethyl-n-butylcarbonyloxy, 1,3- dimethyl-n-butylcarbonyloxy, 2, 2-dimethyl-n- butylcarbonyloxy, 2, 3-dimethyl-n-butylcarbonyloxy, 3,3- dimethyl-n-butylcarbonyloxy, 1-ethyl-n-butylcarbonyloxy, 2-ethyl-n-butylcarbonyloxy, 1,1, 2-trimethyl-n- propylcarbonyloxy, 1,2, 2-trimethyl-n-propylcarbonyloxy, 1-ethyl-1-methyl-n-propylcarbonyloxy, 1-ethyl-2-methyl-n- propylcarbonyloxy, c-hexylcarbonyloxy, 1-methyl-c- pentylcarbonyloxy, 2-methyl-c-pentylcarbonyloxy, 3- methyl-c-pentylcarbonyloxy, 1-ethyl-c-butylcarbonyloxy, 2-ethyl-c-butylcarbonyloxy, 3-ethyl-c-butylcarbonyloxy, 1, 2-dimethyl-c-butylcarbonyloxy, 1, 3-dimethyl-c- butylcarbonyloxy, 2, 2-dimethyl-c-butylcarbonylxoy, 2,3- dimethyl-c-butylcarbonyloxy, 2,4-dimethyl-c- butylcarbonyloxy, 3, 3-dimethyl-c-butylcarbonyloxy, 1-n- propyl-c-propylcarbonyloxy, 2-n-propyl-c- propylcarbonyloxy, 1-i-propyl-c-propycarbonyloxy, 2-i- propyl-c-propylcarbonyloxy, 1, 2, 2-trimethyl-c- propylcarbonyloxy, 1,2, 3-trimethyl-c-propylcarbonyloxy, 2,2, 3-trimethyl-c-propylcarbonyloxy, 1-ethyl-2-methyl-c- propylcarbonyloxy, 2-ethyl-1-methyl-c-propylcarbonyloxy, 2-ethyl-2-methyl-c-propylcarbonyloxy, 2-ethyl-3-methyl-c- propylcarbonyloxy, 1-methyl-1-ethyl-n-pentylcarbonyloxy, 1-heptylcarbonyloxy, 2-heptylcarbonyloxy, l-ethyl-1,2- dimethyl-n-propylcarbonyloxy, l-ethyl-2, 2-dimethyl-n- propylcarbonyloxy, 1-octylcarbonyloxy, 3- octylcarbonyloxy, 4-methyl-3-n-heptylcarbonyloxy, 6- methyl-2-n-heptylcarbonyloxy, 2-propyl-1-n- heptylcarbonyloxy, 2,4,4-trimethyl-l-n-pentylcarbonyloxy, 1-nonylcarbonyloxy, 2-nonylcarbonyloxy, 2, 6-dimethyl-4-n- heptylcarbonyloxy, 3-ethyl-2, 2-dimethyl-3-n- pentylcarbonyloxy, 3, 5,5-trimethyl-l-n-hexylcarbonyloxy, 1-decylcarbonyloxy, 2-decylcarbonyloxy, 4- decylcarbonyloxy, 3, 7-dimethyl-1-n-octylcarbonyloxy, 3,7- dimethyl-3-n-octylcarbonyloxy or the like may be mentioned.
A Ci-io alkylcarbonylamino group may be linear, branched or a C3-10 cycloalkylcarbonylamino group, and methylcarbonylamino, ethylcarbonylamino, n- propylcarbonylamino, i-propylcarbonylamino, c- propylcarbonylamino, n-butylcarbonylamino, i- butylcarbonylamino, s-butylcarbonylamino, t- butylcarbonylamino, c-butylcarbonylamino, 1-methyl-c- propylcarbonylamino, 2-methyl-c-propylcarbonylamino, n- pentylcarbonylamino, 1-methyl-n-butylcarbonylamino, 2- methyl-n-butylcarbonylamino, 3-methyl-n- butylcarbonylamino, 1, 1-dimethyl-n-propylcarbonylamino, 1, 2-dimethyl-n-propylcarbonylamino, 2,2-dimethyl-n- propylcarbonylamino, 1-ethyl-n-propylcarbonylamino, c- pentylcarbonylamino, 1-methyl-c-butylcarbonylamino, 2- methyl-c-butylcarbonylamino, 3-methyl-c- butylcarbonylamino, 1,2-dimethyl-c-propylcarbonylamino, 2,3-dimethyl-c-propylcarbonylamino, 1-ethyl-c- propylcarbonylamino, 2-ethyl-c-propylcarbonylamino, n- hexylcarbonylamino, 1-methyl-n-pentylcarbonylamino, 2- methyl-n-pentylcarbonylamino, 3-methyl-n- pentylcarbonylamino, 4-methyl-n-pentylcarbonylamino, 1,1- dimethyl-n-butylcarbonylamino, 1, 2-dimethyl-n- butylcarbonylamino, 1,3-dimethyl-n-butylcarbonylamino, 2, 2-dimethyl-n-butylcarbonylamino, 2, 3-dimethyl-n- butylcarbonylamino, 3,3-dimethyl-n-butylcarbonylamino, 1- ethyl-n-butylcarbonylamino, 2-ethyl-n-butylcarbonylamino, 1,1,2-trimethyl-n-propylcarbonylamino, 1,2, 2-trimethyl-n- propylcarbonylamino, 1-ethyl-1-methyl-n- propylcarbonylamino, 1-ethyl-2-methyl-n- propylcarbonylamino, c-hexylcarbonylamino, 1-methyl-c- pentylcarbonylamino, 2-methyl-c-pentylcarbonylamino, 3- methyl-c-pentylcarbonylamino, 1-ethyl-c- butylcarbonylamino, 2-ethyl-c-butylcarbonylamino, 3- ethyl-c-butylcarbonylamino, 1, 2-dimethyl-c- butylcarbonylamino, 1,3-dimethyl-c-butylcarbonylamino, 2,2-dimethyl-c-butylcarbonylamino, 2, 3-dimethyl-c- butylcarbonylamino, 2,4-dimethyl-c-butylcarbonylamino, 3, 3-dimethyl-c-butylcarbonylamino, 1-n-propyl-c- propylcarbonylamino, 2-n-propyl-c-propylcarbonylamino, 1- i-propyl-c-propylcarbonylamino, 2-i-propyl-c- propylcarbonylamino, 1,2,2-trimethyl-c-propylcarbonylamino, 1,2,3-trimethyl-c-propylcarbonylamino, 2,2,3-trimethyl-c-propylcarbonylamino, 1-ethyl-2-methyl- c-propylcarbonylamino, 2-ethyl-1-methyl-c- propylcarbonylamino, 2-ethyl-2-methyl-c- propylcarbonylamino, 2-ethyl-3-methyl-c- propylcarbonylamino, 1-methyl-1-ethyl-n- pentylcarbonylamino, 1-heptylcarbonylamino, 2- heptylcarbonylamino, 1-ethyl-l, 2-dimethyl-n- propylcarbonylamino, l-ethyl-2,2-dimethyl-n- propylcarbonylamino, 1-octylcarbonylamino, 3- octylcarbonylamino, 4-methyl-3-n-heptylcarbonylamino, 6- methyl-2-n-heptylcarbonylamino, 2-propyl-1-n- s heptylcarbonylamino, 2,4,4-trimethyl-l-n- pentylcarbonylamino, 1-nonylcarbonylamino, 2- nonylcarbonylamino, 2, 6-dimethyl-4-n-heptylcarbonylamino, 3-ethyl-2, 2-dimethyl-3-n-pentylcarbonylamino, 3,5,5- trimethyl-1-n-hexylcarbonylamino, 1-decylcarbonylamino,
2-decylcarbonylamino, 4-decylcarbonylamino, 3, 7-dimethyl- 1-n-octylcarbonylamino, 3, 7-dimethyl-3-n- octylcarbonylamino or the like may be mentioned. A Ci-io alkylaminocarbonyl group may be a Ci-I0 monoalkylaminocarbonyl group or a Ci-io dialkylaminocarbonyl group. A C1-10 monoalkylaminocarbonyl group may be linear, branched or a C3-10 cycloalkylaminocarbonyl group, and methylaminocarbonyl, ethylaminocarbonyl, n- propylaminocarbonyl, i-propylaminocarbonyl, c- propylaminocarbonyl, n-butylaminocarbonyl, i- butylaminocarbonyl, s-butylaminocarbonyl, t- butylaminocarbonyl, c-butylaminocarbonyl, 1-methyl-c- propylaminocarbonyl, 2-methyl-c-propylaminocarbonyl, n- pentylaminocarbonyl, 1-methyl-n-butylaminocarbonyl, 2- methyl-n-butylaminocarbonyl, 3-methyl-n- butylaminocarbonyl, 1, 1-dimethyl-n-propylaminocarbonyl, 1,2-dimethyl-n-propylaminocarbonyl, 2,2-dimethyl-n- propylaminocarbonyl, 1-ethyl-n-propylaminocarbonyl, c- pentylaminocarbonyl, 1-methyl-c-butylaminocarbonyl, 2- methyl-c-butylaminocarbonyl, 3-methyl-c- butylaminocarbonyl, 1, 2-dimethyl-c-propylaminocarbonyl, 2,3-dimethyl-c-propylaminocarbonyl, 1-ethyl-c- propylaminocarbonyl, 2-ethyl-c-propylaminocarbonyl, n- hexylaminocarbonyl, 1-methyl-n-pentylaminocarbonyl, 2- methyl-n-pentylaminocarbonyl, 3-methyl-n- pentylaminocarbonyl, 4-methyl-n-pentylaminocarbonyl, 1,1- dimethyl-n-butylaminocarbonyl, 1,2-dimethyl-n- butylaminocarbonyl, 1, 3-dimethyl-n-butylaminocarbonyl, 2, 2-dimethyl-n-butylaminocarbonyl, 2, 3-dimethyl-n- butylaminocarbonyl, 3, 3-dimethyl-n-butylaminocarbonyl, 1- ethyl-n-butylaminocarbonyl, 2-ethyl-n-butylaminocarbonyl, 1,1, 2-trimethyl-n-propylaminocarbonyl, 1,2, 2-trimethyl-n- propylaminocarbonyl, 1-ethyl-1-methyl-n- propylaminocarbonyl, 1-ethyl-2-methyl-n- propylaminocarbonyl, c-hexylaminocarbonyl, 1-methyl-c- pentylaminocarbonyl, 2-methyl-c-pentylaminocarbonyl, 3- methyl-c-pentylaminocarbonyl, 1-ethyl-c- butylaminocarbonyl, 2-ethyl-c-butylaminocarbonyl, 3- ethyl-c-butylaminocarbonyl, 1, 2-dimethyl-c- butylaminocarbonyl, 1, 3-dimethyl-c-butylaminocarbonyl, 2, 2-dimethyl-c-butylaminocarbonyl, 2,3-dimethyl-c- butylaminocarbonyl, 2,4-dimethyl-c-butylaminocarbonyl, 3, 3-dimethyl-c-butylaminocarbonyl, 1-n-propyl-c- propylaminocarbonyl, 2-n-propyl-c-propylaminocarbonyl, 1- i-propyl-c-propylaminocarbonyl, 2-i-propyl-c- propylaminocarbonyl, 1,2, 2-trimethyl-c- propylaminocarbonyl, 1,2, 3-trimethyl-c- propylaminocarbonyl, 2, 2, 3-trimethyl-c- propylaminocarbonyl, 1-ethyl-2-methyl-c- propylaminocarbonyl, 2-ethyl-l-methyl-c- propylaminocarbonyl, 2-ethyl-2-methyl-c- propylaminocarbonyl, 2-ethyl-3-methyl-c- propylaminocarbonyl, 1-methyl-1-ethyl-n- pentylaminocarbonyl, 1-heptylaminocarbonyl, 2- heptylaminocarbonyl, 1-ethyl-l, 2-dimethyl-n- propylaminocarbonyl, l-ethyl-2,2-dimethyl-n- propylaminocarbonyl, 1-octylaminocarbonyl, 3- octylaminocarbonyl, 4-methyl-3-n-heptylaminocarbonyl, 6- methyl-2-n-heptylaminocarbonyl, 2-propyl-1-n- heptylaminocarbonyl, 2,4,4-trimethyl-l-n- pentylaminocarbonyl, 1-nonylaminocarbonyl, 2- nonylaminocarbonyl, 2, 6-dimethyl-4-n-heptylaminocarbonyl, 3-ethyl-2,2-dimethyl-3-n-pentylaminocarbonyl, 3,5,5- trimethyl-1-n-hexylaminocarbonyl, 1-decylaminocarbonyl, 2-decylaminocarbonyl, 4-decylaminocarbonyl, 3, 7-dimethyl- 1-n-octylaminocarbonyl, 3, 7-dimethyl-3-n- octylaminocarbonyl or the like may be mentioned.
A C1-I0 dialkylaminocarbonyl group may be symmetric or asymmetric. A symmetric C1-X0 dialkylaminocarbonyl group may be linear, branched or a C3-I0 cycloalkylaminocarbonyl group, and dimethylaminocarbonyl, diethylaminocarbonyl, di-n-propylaminocarbonyl, di-i-propylaminocarbonyl, di-c- propylaminocarbonyl, di-n-butylaminocarbonyl, di-i- butylaminocarbonyl, di-s-butylaminocarbonyl, di-t- butylaminocarbonyl, di-c-butylaminocarbonyl, di- (1- methyl-c-propyl) aminocarbonyl, di- (2-methyl-c- propyl) aminocarbonyl, di-n-pentylaminocarbonyl, di- (1- methyl-n-butyl) aminocarbonyl, di- (2-methyl-n- butyl) aminocarbonyl, di- (3-methyl-n-butyl)aminocarbonyl, di- (1, 1-dimethyl-n-propyl) aminocarbonyl, di-(l,2- dimethyl-n-propyl) aminocarbonyl, di- (2, 2-dimethyl-n- propyl) aminocarbonyl, di- (1-ethyl-n-propyl) aminocarbonyl, di-c-pentylaminocarbonyl, di- (1-methyl-c- butyl) aminocarbonyl, di- (2-methyl-c-butyl)aminocarbonyl, di- (3-methyl-c-butyl) aminocarbonyl, di- (1,2-dimethyl-c- propyl) aminocarbonyl, di- (2,3-dimethyl-c- propyl) aminocarbonyl, di- (1-ethyl-c-propyl) aminocarbonyl, di- (2-ethyl-c-propyl) aminocarbonyl, di-n- hexylaminocarbonyl, di- (1-methyl-n-pentyl) aminocarbonyl, di- (2-methyl-n-pentyl) aminocarbonyl, di- (3-methyl-n- pentyl) aminocarbonyl, di- (4-methyl-n- pentyl) aminocarbonyl, di- (1, 1-dimethyl-n- butyl) aminocarbonyl, di- (1,2-dimethyl-n- butyl)aminocarbonyl, di- (1,3-dimethyl-n- butyl) aminocarbonyl, di- (2,2-dimethyl-n- butyl) aminocarbonyl, di- (2, 3-dimethyl-n- butyl) aminocarbonyl, di- (3, 3-dimethyl-n- butyl)aminocarbonyl, di- (1-ethyl-n-butyl) aminocarbonyl, di- (2-ethyl-n-butyl) aminocarbonyl, di- (1,1, 2-trimethyl-n- propyl) aminocarbonyl, di- (1,2, 2-1rimethyl-n- propyl)aminocarbonyl, di- (1-ethyl-1-methyl-n- propyl) aminocarbonyl, di- (1-ethyl-2-methyl-n- propyl) aminocarbonyl, di-c-hexylaminocarbonyl, di- (1- methyl-c-pentyl) aminocarbonyl, di- (2-methyl-c- pentyl) aminocarbonyl, di- (3-methyl-c- pentyl) aminocarbonyl, di- (1-ethyl-c-butyl) aminocarbonyl, di- (2-ethyl-c-butyl) aminocarbonyl, di- (3-ethyl-c- butyl) aminocarbonyl, di- (1, 2-dimethyl-c- butyl) aminocarbonyl, di- (1, 3-dimethyl-c- butyl) aminocarbonyl, di- (2,2-dimethyl-c- butyl) aminocarbonyl, di- (2, 3-dimethyl-c- butyl) aminocarbonyl, di- (2,4-dimethyl-c- butyl)aminocarbonyl, di- (3,3-dimethyl-c- butyl) aminocarbonyl, di- (1-n-propyl-c- propyl) aminocarbonyl, di- (2-n-propyl-c- propyl) aminocarbonyl, di- (1-i-propyl-c- propyl) aminocarbonyl, di- (2-i-propyl-c- propyl) aminocarbonyl, di- (1,2, 2-trimethyl-c- propyl) aminocarbonyl, di- (1,2, 3-trimethyl-c- propyl) aminocarbonyl, di- (2,2, 3-trimethyl-c- propyl) aminocarbonyl, di- (1-ethyl-2-methyl-c- propyl) aminocarbonyl, di- (2-ethyl-l-methyl-c- propyl) aminocarbonyl, di- (2-ethyl-2-methyl-c- propyl) aminocarbonyl, di- (2-ethyl-3-methyl-c- propyl) aminocarbonyl, di- (1-methyl-l-ethyl-n- pentyl) aminocarbonyl, di- (1-heptyl) aminocarbonyl, di- (2■ heptyl) aminocarbonyl, di- (1-ethyl-l,2-dimethyl-n- propyl) aminocarbonyl, di- (l-ethyl-2,2-dimethyl-n- propyl) aminocarbonyl, di- (1-octyl) aminocarbonyl, di- (3- octyl) aminocarbonyl, di- (4-methyl-3-n- heptyl) aminocarbonyl, di- (6-methyl-2-n- heptyl) aminocarbonyl, di- (2-propyl-1-n- heptyl) aminocarbonyl, di- (2,4,4-trimethyl-l-n- pentyl) aminocarbonyl, di- (1-nonyl) aminocarbonyl, di-(2-- nonyl) aminocarbonyl, di- (2, 6-dimethyl-4-n- heptyl) aminocarbonyl, di- (3-ethyl-2,2-dimethyl-3-n- pentyl) aminocarbonyl, di- (3, 5, 5-trimethyl-1-n- hexyl) aminocarbonyl, di- (1-decyl) aminocarbonyl, di- (2- decyl) aminocarbonyl, di- (4-decyl) aminocarbonyl, di-(3,7- dimethyl-1-n-octyl)aminocarbonyl, di- (3, 7-dimethyl-3-n- octyl) aminocarbonyl or the like may be mentioned. An asymmetric C1-I0 dialkylaminocarbonyl group may be linear, branched or a C3_10 cycloalkylaminocarbonyl group, and (methyl, ethyl) aminocarbonyl, (methyl, n- propyl) aminocarbonyl, (methyl, i-propyl) aminocarbonyl, (methyl, c-propyl) aminocarbonyl, (methyl, n- butyl) aminocarbonyl, (methyl, i-butyl) aminocarbonyl, (methyl, s-butyl) aminocarbonyl, (methyl, t- butyl) aminocarbonyl, (methyl, n-pentyl) aminocarbonyl, (methyl, c-pentyl) aminocarbonyl, (methyl, n- hexyl) aminocarbonyl, (methyl, c-hexyl) aminocarbonyl, (ethyl, n-propyl) aminocarbonyl, (ethyl, i- propyl) aminocarbonyl, (ethyl, c-propyl) aminocarbonyl, (ethyl, n-butyl) aminocarbonyl, (ethyl, i- butyl) aminocarbonyl, (ethyl, s-butyl) aminocarbonyl, (ethyl, t-butyl) aminocarbonyl, (ethyl, n- pentyl) aminocarbonyl, (ethyl, c-pentyl) aminocarbonyl, (ethyl, n-hexyl) aminocarbonyl, (ethyl, c- hexyl) aminocarbonyl, (n-propyl, i-propyl) aminocarbonyl, (n-propyl, c-propyl) aminocarbonyl, (n-propyl, n- butyl) aminocarbonyl, (n-propyl, i-butyl) aminocarbonyl, (n-propyl, s-butyl)aminocarbonyl, (n-propyl, t- butyl) aminocarbonyl, (n-propyl, n-pentyl) aminocarbonyl, (n-propyl, c-pentyl) aminocarbonyl, (n-propyl, n- hexyl) aminocarbonyl, (n-propyl, c-hexyl) aminocarbonyl, (i-propyl, c-propyl) aminocarbonyl, (i-propyl, n- butyl) aminocarbonyl, (i-propyl, i-butyl) aminocarbonyl, (i-propyl, s-butyl) aminocarbonyl, (i-propyl, t- butyl) aminocarbonyl, (i-propyl, n-pentyl) aminocarbonyl, (i-propyl, c-pentyl) aminocarbonyl, (i-propyl, n- hexyl) aminocarbonyl, (i-propyl, c-hexyl) aminocarbonyl, (c-propyl, n-butyl) aminocarbonyl, (c-propyl, i- butyl) aminocarbonyl, (c-propyl, s-butyl) aminocarbonyl, (c-propyl, t-butyl) aminocarbonyl, (c-propyl, n- pentyl) aminocarbonyl, (c-propyl, c-pentyl) aminocarbonyl, (c-propyl, n-hexyl) aminocarbonyl, (c-propyl, c- hexyl) aminocarbonyl, (n-butyl, i-butyl) aminocarbonyl, (n- butyl, s-butyl) aminocarbonyl, (n-butyl, t- butyl) aminocarbonyl, (n-butyl, n-pentyl) aminocarbonyl, (n-butyl, c-pentyl) aminocarbonyl, (n-butyl, n- hexyl) aminocarbonyl, (n-butyl, c-hexyl) aminocarbonyl, (i- butyl, s-butyl) aminocarbonyl, (i-butyl, t- butyl) aminocarbonyl, (i-butyl, n-pentyl) aminocarbonyl, (i-butyl, c-pentyl) aminocarbonyl, (i-butyl, n- hexyl) aminocarbonyl, (i-butyl, c-hexyl) aminocarbonyl, (s- butyl, t-butyl) aminocarbonyl, (s-butyl, n- pentyl) aminocarbonyl, (s-butyl, c-pentyl) aminocarbonyl, (s-butyl, n-hexyl) aminocarbonyl, (s-butyl, c- hexyl) aminocarbonyl, (t-butyl, n-pentyl) aminocarbonyl, (t-butyl, c-pentyl) aminocarbonyl, (t-butyl, n- hexyl) aminocarbonyl, (t-butyl, c-hexyl) aminocarbonyl, (n- pentyl, c-pentyl)aminocarbonyl, (n-pentyl, n- •hexyl) aminocarbonyl, (n-pentyl, c-hexyl) aminocarbonyl, (c-pentyl, n-hexyl) aminocarbonyl, (c-pentyl, c- hexyl) aminocarbonyl, (n-hexyl, c-hexyl) aminocarbonyl, (methyl, n-heptyl) aminocarbonyl, (methyl, n- octyl) aminocarbonyl, (methyl, n-nonyl) aminocarbonyl, (methyl, n-decyl) aminocarbonyl, (methyl, n- heptyl) aminocarbonyl, (ethyl, n-octyl) aminocarbonyl, (ethyl, n-nonyl) aminocarbonyl, (ethyl, n- decyl) aminocarbonyl or the like may be mentioned.
A Ci-io monoalkylamino group may be linear, branched or a C3-10 cycloalkylamino group, and methylamino, ethylamino, n-propylamino, i-propylamino, c-propylamino, n-butylamino, i-butylamino, s-butylamino, t-butylamino, c-butylamino, 1-methyl-c-propylamino, 2-methyl-c- propylamino, n-pentylamino, 1-methyl-n-butylamino, 2- methyl-n-butylamino, 3-methyl-n-butylamino, 1, 1-dimethyl- n-propylamino, 1, 2-dimethyl-n-propylamino, 2, 2-dimethyl- n-propylamino, 1-ethyl-n-propylamino, c-pentylamino, 1- methyl-c-butylamino, 2-methyl-c-butylamino, 3-methyl-c- butylamino, 1,2-dimethyl-c-propylamino, 2, 3-dimethyl-c- propylamino, 1-ethyl-c-propylamino, 2-ethyl-c- propylamino, n-hexylamino, 1-methyl-n-pentylamino, 2- methyl-n-pentylamino, 3-methyl-n-pentylamino, 4-methyl-n- pentylamino, 1, 1-dimethyl-n-butylamino, 1,2-dimethyl-n- butylamino, 1,3-dimethyl-n-butylamino, 2, 2-dimethyl-n- butylamino, 2,3-dimethyl-n-butylamino, 3, 3-dimethyl-n- butylamino, 1-ethyl-n-butylamino, 2-ethyl-n-butylamino, 1, 1, 2-trimethyl-n-propylamino, 1, 2, 2-trimethyl-n- propylamino, 1-ethyl-1-methyl-n-propylamino, l-ethyl-2- methyl-n-propylamino, c-hexylamino, 1-methyl-c- pentylamino, 2-methyl-c-pentylamino, 3-methyl-c- pentylamino, 1-ethyl-c-butylamino, 2-ethyl-c-butylamino, 3-ethyl-c-butylamino, 1,2-dimethyl-c-butylamino, 1,3- dimethyl-c-butylamino, 2,2-dimethyl-c-butylamino, 2,3- dimethyl-c-butylamino, 2,4-dimethyl-c-butylamino, 3,3- dimethyl-c-butylamino, 1-n-propyl-c-propylamino, 2-n- propyl-c-propylamino, 1-i-propyl-c-propylamino, 2-i- propyl-c-propylamine, 1,2,2-trimethyl-c-propylamine, 1,2, 3-trimethyl-c-propylamino, 2,2, 3-trimethyl-c- propylamino, 1-ethyl-2-methyl-c-propylamino, 2-ethyl-l- methyl-c-propylamino, 2-ethyl-2-methyl-c-propylamino, 2- ethyl-3-methyl-c-propylamino, 1-methyl-1-ethyl-n- pentylamino, 1-heptylamino, 2-heptylamino, l-ethyl-1,2- dimethyl-n-propylamino, l-ethyl-2, 2-dimethyl-n- propylamino, 1-octylamino, 3-octylamino, 4-methyl-3-n- heptylamino, 6~methyl-2-n-heptylamino, 2-propyl-1-n- heptylamino, 2,4,4-trimethyl-l-n-pentylamino, 1- nonylamino, 2-nonylamino, 2, 6-dimethyl-4-n-heptylamino, 3-ethyl-2,2-dimethyl-3-n-pentylamino, 3,5, 5-trimethyl-l- n-hexylamino, 1-decylamino, 2-decylamino, 4-decylamino, 3, 7-dimethyl-1-n-octylamino, 3, 7-dimethyl-3-n-octylamino or the like may be mentioned.
A C1-I0 dialkylamino group may be symmetric or asymmetric. A symmetric C1-I0 dialkylamino group may be linear, branched or a C3.10 cycloalkylamino group, and dimethylamino, diethylamino, di-n-propylamino, di-i- propylamino, di-c-propylamino, di-n-butylamino, di-i- butylamino, di-s-butylamino, di-t-butylamino, di-c- butylamino, di- (1-methyl-c-propyl) amino, di- (2-methyl-c- propyl) amino, di-n-pentylamino, di- (1-methyl-n- butyl) amino, di- (2-methyl-n-butyl) amino, di- (3-methyl-n- butyl) amino, di- (1, 1-dimethyl-n-propyl) amino, di-(l,2- dimethyl-n-propyl) amino, di- (2, 2-dimethyl-n-propyl) amino, di- (1-ethyl-n-propyl) amino, di-c-pentylamino, di- (1- methyl-c-butyl) amino, di- (2-methyl-c-butyl) amino, di- (3- methyl-c-butyl) amino, di- (1, 2-dimethyl-c-propyl) amino, di- (2, 3-dimethyl-c-propyl) amino, di- (1-ethyl-c- propyl)amino, di- (2-ethyl-c-propyl) amino, di-n- hexylamino, di- (1-methyl-n-pentyl) amino, di- (2-methyl-n- pentyl) amino, di- (3-methyl-n-pentyl) amino, di- (4-methyl- n-pentyl) amino, di- (1, 1-dimethyl-n-butyl) amino, di-(l,2- dimethyl-n-butyl) amino, di- (1, 3-dimethyl-n-butyl) amino, di- (2, 2-dimethyl-n-butyl) amino, di- (2,3-dimethyl-n- butyl) amino, di- (3, 3-dimethyl-n-butyl) amino, di- (1-ethyl- n-butyl) amino, di- (2-ethyl-n-butyl) amino, di- (1,1,2- trimethyl-n-propyl) amino, di- (1,2, 2-trimethyl-n- propyl) amino, di- (1-ethyl-1-methyl-n-propyl) amino, di- (1- ethyl-2-methyl-n-propyl)amino, di-c-hexylamino, di- (1- methyl-c-pentyl) amino, di- (2-methyl-c-pentyl) amino, di- (3-methyl-c-pentyl) amino, di- (1-ethyl-c-butyl) amino, di- (2-ethyl-c-butyl) amino, di- (3-ethyl-c-butyl) amino, di- (1, 2-dimethyl-c-butyl)amino, di- (1, 3-dimethyl-c- butyl) amino, di- (2, 2-dimethyl-c-butyl) amino, di-(2,3- dimethyl-c-butyl) amino, di- (2,4-dimethyl-c-butyl) amino, di- (3, 3-dimethyl-c-butyl) amino, di- (1-n-propyl-c- propyl) amino, di- (2-n-propyl-c-propyl) amino, di- (1-i- propyl-c-propyl) amino, di- (2-i-propyl-c-propyl) amino, di- (1,2,2-trimethyl-c-propyl) amino, di- (1,2, 3-trimethyl-c- propyl) amino, di- (2, 2, 3-trimethyl-c-propyl) amino, di- (1- ethyl-2-methyl-c-propyl) amino, di- (2-ethyl-l-methyl-c- propyl) amino, di- (2-ethyl-2-methyl-c-propyl) amino, di- (2■ ethyl-3-methyl-c-propyl) amino, di- (1-methyl-1-ethyl-n- pentyl) amino, di- (1-heptyl) amino, di- (2-heptyl) amino, di- (1-ethyl-1, 2-dimethyl-n-propyl) amino, di- (l-ethyl-2, 2- dimethyl-n-propyl) amino, di- (1-octyl) amino, di-(3- octyl)amino, di- (4-methyl-3-n-heptyl) amino, di- (6-methyl- 2-n-heptyl) amino, di- (2-propyl-1-n-heptyl) amino, di- (2,4,4-trimethyl-l-n-pentyl) amino, di- (1-nonyl) amino, di- (2-nonyl) amino, di- (2, 6-dimethyl-4-n-heptyl) amino, di-(3- ethyl-2,2-dimethyl-3-n-pentyl) amino, di- (3,5, 5-trimethyl- 1-n-hexyl) amino, di- (1-decyl) amino, di- (2-decyl) amino, di- (4-decyl) amino, di- (3, 7-dimethyl-1-n-octyl) amino, di- (3, 7-dimethyl-3-n-octyl) amino or the like may be mentioned.
An asymmetric C1-10 dialkylamino group may be linear, branched or a C3-10 cycloalkylamino group, and (methyl, ethyl) amino, (methyl, n-propyl) amino, (methyl, i- propyl) amino, (methyl, c-propyl) amino, (methyl, n- butyl) amino, (methyl, i-butyl) amino, (methyl, s- butyl) amino, (methyl, t-butyl) amino, (methyl, n- pentyl) amino, (methyl, c-pentyl) amino, (methyl, n- hexyl) amino, (methyl, c-hexyl) amino, (ethyl, n- propyl) amino, (ethyl, i-propyl) amino, (ethyl, c- propyl) amino, (ethyl, n-butyl) amino, (ethyl, i- butyl) amino, (ethyl, s-butyl) amino, (ethyl, t- butyl) amino, (ethyl, n-pentyl) amino, (ethyl, c- pentyl) amino, (ethyl, n-hexyl) amino, (ethyl, c- hexyl) amino, (n-propyl, i-propyl) amino, (n-propyl, c- propyl) amino, (n-propyl, n-butyl) amino, (n-propyl, i- butyl) amino, (n-propyl, s-butyl) amino, (n-propyl, t- butyl) amino, (n-propyl, n-pentyl) amino, (n-propyl, c- pentyl) amino, (n-propyl, n-hexyl) amino, (n-propyl, c- hexyl) amino, (i-propyl, c-propyl) amino, (i-propyl, n- butyl) amino, (i-propyl, i-butyl) amino, (i-propyl, s- butyl) amino, (i-propyl, t-butyl) amino, (i-propyl, n- pentyl) amino, (i-propyl, c-pentyl) amino, (i-propyl, n- hexyl) amino, (i-propyl, c-hexyl) amino, (c-propyl, n- butyl) amino, (c-propyl, i-butyl) amino, (c-propyl, s- butyl) amino, (c-propyl, t-butyl) amino, (c-propyl, n- pentyl) amino, -(c-propyl, c-pentyl) amino, (c-propyl, n- hexyl) amino, (c-propyl, c-hexyl) amino, (n-butyl, i- butyl) amino, (n-butyl, s-butyl) amino, (n-butyl, t- butyl) amino, (n-butyl, n-pentyl) amino, (n-butyl, c- pentyl) amino, (n-butyl, n-hexyl) amino, (n-butyl, c- hexyl) amino, (i-butyl, s-butyl) amino, (i-butyl, t- butyl) amino, (i-butyl, n-pentyl) amino, (i-butyl, c- pentyl) amino, (i-butyl, n-hexyl) amino, (i-butyl, c- hexyl) amino, (s-butyl, t-butyl) amino, (s-butyl, n- pentyl) amino, (s-butyl, c-pentyl) amino, (s-butyl, n- hexyl) amino, (s-butyl, c-hexyl) amino, (t-butyl, n- pentyl) amino, (t-butyl, c-pentyl) amino, (t-butyl, n- hexyl) amino, (t-butyl, c-hexyl) amino, (n-pentyl, c- pentyl) amino, (n-pentyl, n-hexyl) amino, (n-pentyl, c- hexyl) amino, (c-pentyl, n-hexyl) amino, (c-pentyl, c- hexyl) amino, (n-hexyl, c-hexyl) amino, (methyl, n- heptyl) amino, (methyl, n-octyl) amino, (methyl, n- nonyl) amino, (methyl, n-decyl) amino, (methyl, n- heptyl) amino, (ethyl, n-octyl) amino, (ethyl, n- nonyl) amino, (ethyl, n-decyl) amino or the like may be mentioned.
The protecting group in a protected hydroxyl group may be a Ci-4 alkoxymethyl group (such as MOM: methoxymethyl, MEM: 2-methoxyethoxymethyl, ethoxymethyl, n-propoxymethyl, i-propoxymethyl, n-butoxymethyl, iBM: isobutyloxyraethyl, BUM: t-butoxymethyl, POM: pivaloyloxymethyl, SEM: trimethylsilylethoxymethyl and the like, preferably a Ci_2 alkoxymethyl or the like) , an aryloxymethyl (such as BOM: benzyloxymethyl, PMBM: p- methoxybenzyloxymethyl, p-AOM: p-anisyloxymethyl and the like) , a C1-4 alkylaminomethyl group (such as dimethylaminomethyl) , a substituted acetamidomethyl group (such as Acm: acetamidomethyl, Tacm: trimethylacetamidomethyl and the like) , a substituted thiomethyl group (such as MTM: methylthiomethyl, PTM: phenylthiomethyl, Btm: benzylthiomethyl and the like) , a carboxyl group, a Ci-? acyl group (such as formyl, acetyl, fluoroacetyl, difluoroacetyl, trifluoroacetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, propionyl, Pv: pivaloyl, tigloyl and the like) , an arylcarbonyl group (such as benzoyl, benzoylformyl, benzoylpropionyl, phenylpropionyl and the like) , a Cx-4 alkoxycarbonyl group (such as methoxycarbonyl, ethoxycarbonyl, n- propoxycarbonyl, i-propoxycarbonyl, n-butoxycarbonyl, i- butoxycarbonyl, BOC: t-butoxycarbonyl, AOC: t- amyloxycarbonyl, VOC: vinyloxycarbonyl, AOC: allyloxycarbonyl, Teoc: 2- (trimethylsilyl)ethoxycarbonyl, Troc : 2,2,2-trichloroethoxycarbonyl and the like, preferably BOC and the like) , an aryloxycarbonyl group (such as Z: benzyloxycarbonyl, p-nitrobenzyloxycarbonyl, MOZ: p-methoxybenzyloxycarbonyl and the like) , a Ci_4 alkylaminocarbonyl group (such as methylcarbamoyl, Ec: ethylcarbamoyl, n-propylcarbamoyl, and the like), an arylaminocarbonyl group (such as phenylcarbamoyl and the like) , a trialkylsilyl group (such as TMS: trimethylsilyl, TES: triethylsilyl, TIPS: triisopropylsilyl, DEIPS: diethylisopropylsiIyI, DMIPS: dimethylisopropylsilyl, DTBMS: di-t-butylmethylsilyl, IPDMS: isopropyldimethylsilyl, TBDMS: t- butyldimethylsilyl, TDS: thexyldimethylsilyl and the like, preferably t-butyldimethylsilyl and the like) , a trialkylarylsilyl group (such as DPMS: diphenylmethylsilyl, TBDPS: t-butyldiphenylsilyl, TBMPS: t-butyldimethoxyphenylsilyl, TPS: triphenylsilyl and the like), an alkylsulfonyl group, (such as Ms: methanesulfonyl, ethanesulfonyl and the like) or an arylsulfonyl group (such as benzenesulfonyl, Ts: p- toluenesulfonyl, p-chlorobenzenesulfonyl, MBS: p- methoxybenzenesulfonyl, m-nitrobenzenesulfonyl, iMds: 2, 6-dimethoxy-4-methylbenzenesulfonyl, Mds : 2, 6-dimethyl- 4-methoxybenzenesulfonyl, Mtb: 2,4,6- trimethoxybenzenesulfonyl, Mte : 2, 3, 5, 6-tetramethyl-4- methoxybenzenesulfonyl, Mtr: 2, 3, 6-trimethyl-4- methoxybenzenesulfonyl, Mts : 2,4,6- trimethylbenzenesulfonyl, Pme: pentamethylbenzenesulfonyl and the like) .
Specific preferred examples of the substituent R1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group) , furyl groups (a 2-furyl group and a 3- furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group) , quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4- quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6- isoquinolyl group, a 7-isoquinolyl group and a 8- isoquinolyl group) optionally substituted with one or more of the following substituents . Substituents: a Ci_i0 alkyl group, a halogen atom, a Ci-io alkyl group substituted with one or more halogen atoms, a Ci_i0 alkoxy group substituted with one or more halogen atoms, a nitro group, an amino group, an amino group substituted with one or two Ci-I0 alkyl groups, an amino group substituted with a Ci_io alkylcarbonyl group, a thiol group substituted with a Ci-io alkyl group, a thiol group substituted with a Ci-io alkylcarbonyl group, a hydroxyl group, a C1-6 alkoxy group, a Ci-io alkylcarbonyloxy group, a C1-I0 alkoxycarbonyl group and a Ci-io alkylcarbonyl group.
Particularly preferred examples of the substituent R1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group) , furyl groups (a 2-fury1 group and a 3-furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group) , quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4- quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl. group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6- isoquinolyl group, a 7-isoquinolyl group and a 8- isoquinolyl group) optionally substituted with one or more of the following substituents.
Substituents: a methyl group, a t-butyl group, a trifluoromethyl group, a trifluoromethoxy group, a chlorine atom, a bromine atom, a fluorine atom, a methoxy group, a methylamino group, a dimethylamino group, a t- butyloxy group and a t-butylamino group.
Still further preferred specific examples of the substituent are a 3-methyl-phenyl group, a 4-methyl- phenyl group, a 3,4-dimethyl-phenyl group, a 3-t-butyl- phenyl group, a 4-t-butyl-phenyl group, a 3- trifluoromethyl-phenyl group, a 4-trifluoromethoxy-phenyl group, a 4-trifluoromethyl-phenyl group, a 3,4- ditrifluoromethyl-phenyl group, a 3-chloro-phenyl group, a 4-chloro-phenyl group, a 4-bromo-phenyl group, a 3- fluoro-phenyl group, a 4-fluoro-phenyl group, a 3,4- dichloro-phenyl group, a 4-methoxy-phenyl group, a 4- methylamino-phenyl group, a 3-methyl-thienyl group, a 4- methyl-thienyl group, a 3,4-dimethyl-thienyl group, a 3- t-butyl-thienyl group, a 4-t-butyl-thienyl group, a 3- trifluoromethyl-thienyl group, a 4-trifluoromethyl- thienyl group, a 3,4-ditrifluoromethyl-thienyl group, a 3-chloro-thienyl group, a 4-chloro-thienyl group, a 3- fluoro-thienyl group, a 4-fluoro-thienyl group, a 3,4- dichloro-thienyl group, a 4-methoxy-thienyl group, a 4- methylamino-thienyl group, a 3-methyl-furyl group, a 4- methyl-furyl group, a 3,4-dimethyl-furyl group, a 3-t- butyl-furyl group, a 4-t-butyl-furyl group, a 3- trifluoromethyl-furyl group, a 4-trifluoromethyl-furyl group, a 3,4-ditrifluoromethyl-furyl group, a 3-chloro- furyl group, a 4-chloro-furyl group, a 3-fluoro-furyl group, a 4-fluoro-furyl group, a 3 ,4-dichloro-furyl group, a 4-methoxy-furyl group, a 4-methyl-furyl group, a 5-chloro-pyridazinyl group, a 5-methyl-pyridazinyl group, a 5-methoxy-pyridazinyl group, a 4-chloro-pyridazinyl group, a 4-methylpyridazinyl group, a 4-methoxy- pyridazinyl group, a 4-t-butoxy-pyridazinyl group and the like.
Specific preferable examples of L1 are a bond, CH2, an oxygen atom, a sulfur atom, NH, N-Me, N-CHO, CHMe, CMe2, N-CH2Ph and the like, and particularly preferable examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
Specific preferable examples of the substituent R2 are a hydrogen atom, a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a t-butyl group, and a phenyl group (the methyl group, the ethyl group, the n- propyl group, the i-propyl group, the t-butyl group and the phenyl group may be optionally substituted with an amino group, a monomethylamino group, a dimethylamino group, a monoethylamino group, a diethylamino group, a methoxy group, an ethoxy group, a methoxycarbonyl group, an ethoxycarbonyl group, a methylcarbonyloxy group, an ethylcarbonyloxy group, a methylcarbonylamino group or an ethylcarbonylamino group and the like) , and particularly preferable examples are a hydrogen atom, a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a t- butyl group, a phenyl group and the like. Specific preferable examples of L2 are a bond, CH2, an oxygen atom, a sulfur atom, NH, N-Me, N-CHO, CHMe, CMe2, N-CH2Ph and the like, and particularly preferable examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
Specific preferable examples of L3 are a bond, CH2, an oxygen atom, a sulfur atom, NH, NH-OH, N-Me, N-CHO, CHMe, CMe2, N-CH2PH and the like, and particularly preferred examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
Specific preferable examples of X are OH, SH, NH2, OMe, SMe, NHMe, NHEt, NH-CHO, NH-CH2Ph, OCH2Ph, SCH2Ph, OC (=0) CH3, SC(=0) CH3, NHC(=0) CH3 and the like, and particularly preferable examples are OH, SH, NH2 and the like.
Specific preferable examples of Y are an oxygen atom, a sulfur atom, NH, N-OH, N-CHO, N-Me, N-CH2Ph, N- OMe, N-OCH2Ph an the like, and particularly preferred examples are an oxygen atom, a sulfur atom, NH, N-OH and the like.
Specific preferable examples of L4 are a bond, CH2, an oxygen atom, a sulfur atom, NH, N-Me, N-CHO, CHMe, CMe2, N-CH2Ph and the like, and particularly preferred examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
Specific preferable examples of the substituent R3 are a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a s-butyl group, a t- butyl group, a c-propyl group, a c-butyl group, a c- pentyl group, a c-hexyl group, an ethynyl group, a 1- propynyl group, a 2-propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a l-methyl-2- butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3- butynyl group, a 3-methyl-1-butynyl group and the following heterocyclic groups optionally substituted with one or more of the following substituents. Heterocyclic groups
Figure imgf000142_0001
Substituents : a hydrogen atom, a hydroxyl group, an amino group, a halogen atom, a nitro group, a thiol group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a hydroxylcarbamoyl group, a cyanocarbamoyl group, a sulfamoyl group, a hydroxysulfamoyl group, a cyanosulfamoyl group, a tetrazole group, a phenyl group, a thienyl group, a pyridyl group, a furyl group, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H,
-CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, -(C=O)CO2 H, -CH2(C=O)CO2H, -NH(C=O)CO2H, -NHS (=0) 2NH2, a Ci-10 alkyl group (the C1.10 alkyl group may be substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, the following aryl groups, the following heterocyclic groups and C1-I0 alkylamino groups (the C1-10 alkylamino groups may be substituted with one or more of the following aryl groups • or one or more of the heterocyclic groups) ) , a C2-10 alkenyl group, a C2.10 alkynyl group, a C2.9 heterocyclic group, a C1-10 thioalkyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a Ci-I0 alkylaminocarbonyl group, a C1-10 dialkylaminocarbonyl group, a mono- or di-Ci-io alkylamino group, a Ci_io alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, an aminocarbonyl group, a C1-10 alkylcarbonylamino group (the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkylaminocarbonyl group, the C1-10 dialkylaminocarbonyl group, the mono- or di-C1-:Lo alkylamino group, the C1-10 alkylcarbonyloxy group, the C1- 10 alkoxycarbonyl group, the aminocarbonyl group and the Ci-io alkylcarbonylamino group may be substituted with one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, amino groups, the following aryl groups and the following heterocyclic groups) , the following aryl groups and the following heterocyclic groups.
Aryl groups: a phenyl group, thienyl groups (a 2- thienyl group and a 3-thienyl group) , furyl groups (a 2- furyl group and a 3-furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and 4- pyridyl group) , pyrimidinyl groups (a 2-pyrimidinyl group, a 4-pyrimidinyl group and a 5-pyrimidinyl group) , quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3- isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) .
Heterocyclic groups: a 1,3,4-oxadiazole group, a 1, 3,4-thiadiazole group, a 1, 2,4-oxadiazole group, a 1, 2,4-thiadiazole group, a 1, 2, 5-oxadiazole group, a 1,2, 5-thiadiazole group, a 1,2-oxazole group and a 1,2- thiazole group.
Still further specific preferable examples of the substituent R3 are a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a n-butyl group, a s- butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1- butynyl group, a 2-butynyl group, a 3-butynyl group, a 1- pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a 1-methyl-2-butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3-butynyl group, a 3-methyl-1-butynyl group and the following heterocyclic groups optionally substituted with one or more substituents optionally selected from substituent set A and with one or more substituents optionally selected from substituent set B. Heterocyclic groups
Figure imgf000145_0001
Substituent set A: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a hydroxycarbamoyl group, a cyanocarbamoyl group, a sulfamoyl group, a hydroxysulfamoyl group, a cyanosulfamoyl group, a tetrazole group, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H and an alkoxycarbonyl group. Substituent set B: a hydroxy1 group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a hydroxycarbamoyl group, a cyanocarbamoyl group, a sulfamoyl group, a nitro group, a cyano group, a halogen atom, a C1-I0 alkyl group, a Ci_10 alkyl group substituted with one or more fluorine atoms, a sulfamoyl group substituted with a Ci_i0 alkyl group, a carbamoyl group substituted with a Ci-io alkyl group, a C1- io alkylcarbonylamino group and a Ci-10 alkylaminocarbonyl group (the C1-10 alkylcarbonylamino group and the Cx-I0 alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of phenyl groups, pyridyl groups, thienyl groups and furyl groups) .
Favorable compounds as the thrombopoietin receptor activator, the preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective and the platelet increasing agent of the present invention are as follows. 1) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 2) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 3) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is NR9 other than NH (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-io alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-io alkoxycarbonyl group, a Ci_i0 alkylcarbonyl group (the Ci_i0 alkyl group, the C2-β alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-io alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2_14 aryloxy groups) or a C2_i4 aryloxy group (the C2-i4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-H0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
4) Compounds represented by the formula (1) wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-I0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a Ci-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-I0 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2.14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or CU-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups) , a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyls group, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) , SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or CU-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2_i4 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-S alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) , a C2_14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms), C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-I0 alkyl group, a C2-β alkenyl group, a C2-β alkynyl group, a Ci-I0 alkylcarbonyloxy group, a Ci_i0 alkoxycarbonyl group, a C1-I0 alkylcarbonyl group (the Ci-10 alkyl group, the C2-s alkenyl group, the C2-β alkynyl group, the Ci-I0 alkylcarbonyloxy group, the C1-I0 alkoxycarbonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-X0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms), C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-H-0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Cα_10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-I4 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)mi~E- (CH2)m2~ (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-O-0 alkyl group, a C2-i4 aryl group, a C1-I0 alkoxy group, a C2-I4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-I0 alkoxy group, a C1-10 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci-no alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-I0 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Cx-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups)) , and each of ml and m2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5) ) ) ) , and B is a oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
5) Compounds represented by the formula (1) wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2_6 alkenyl or a C2_6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a Cx-I0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-β alkenyl groups or one or two C2-6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a C1-I0 alkyl group, a C2-6 alkenyl group, a C2_6 alkynyl group, a Ci-10 alkylcarbonylamino group, a mono- or (U-C1-I0 alkylamino group, a Ci-10 alkoxy group (the C1.10 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the C1-H0 alkylcarbonylamino group, the mono- or di-Ci_i0 alkylamino group and the Ci_i0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_io alkoxy groups, Ci-10 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2_14 aryloxy groups (the C2-I4 aryl group and the C2--.4 aryloxy group may be substituted with one or more C1-S alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2_14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-H0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Cχ.lo alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-^0 alkylcarbonylamino groups, amino groups, mono- or (U-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2-i4 aryloxy groups) , a C2-14 aryloxy group (the C2-i4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2_14 aryloxy groups) , SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1^10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2_s alkenyl group, the C2_6 alkynyl group and the C1-O-0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-J-0 alkoxy groups, Ci_i0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2.14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-X0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-e alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci_10 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2-I4 aryloxy groups) , a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-S alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, C1-H-0 alkylcarbonylamino groups, amino groups, mono- or di-C1-^-0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2-I4 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a Ci_10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-I0 alkylcarbonyloxy group, a Ci-10 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the Ci-io alkoxycarbonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-X0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2_14 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2_14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-I4 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)mi-E- (CH2)m2~ (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a Ci-io alkyl group, a C2_14 aryl group, a C1-10 alkoxy group, a C2-i4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-10 alkoxy group, a Ci_i0 alkylcarbonyloxy group, a Ci-10 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Ci-10 alkyl group, the C2_6 alkenyl group, the C2.6 alkynyl group, the Ci-I0 alkoxy group, the Ci_i0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Cx-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-β alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci_10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci_10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups)), and each of ml and m2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5) ) ) ) , and B is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
6) Compounds represented by the formula (1) wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2_6 alkynyl group or a Ci-I0 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-β alkynyl group, a Ci-io alkylcarbonylamino group, a mono- or CU-C1-X0 alkylamino group, a Ci-I0 alkoxy group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkylcarbonylamino group, the mono- or di-Ci-I0 alkylamino group and the Ci_i0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci_i0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Ci-io alkoxycarbonyl groups, CX-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2.14 aryloxy groups) , a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-i0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.14 aryl groups and C2-I4 aryloxy groups) , SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a Ci-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci_i0 alkoxy group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci_io alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups,an amino groups, mono- or di- Ci_io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2_14 aryloxy groups may be substituted with one or more Cx-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-β alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-I4 aryloxy groups), a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Cx-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Ci-lo alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups., Cx-I0 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a Ci_io alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Cx-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci_io alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-β alkynyl group, the Ci-io alkylcarbonyloxy group, the Cx-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Ci-10 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_i4 aryl groups and C2-14 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)mi-E- (CH2)m2- (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a Ci-m alkyl group, a C2-14 aryl group, a Cx-I0 alkoxy group, a C2-I4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci-10 alkylcarbonyloxy group, a Ci-10 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the Ci-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci_i0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2_i4 aryl group (the C2_i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci.10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, Cχ.lo alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-H0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups)) , and each of ml and m2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5) ) ) ) , and B is NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-io alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-X0 alkoxy group, a C1-I0 alkylcarbonyloxy group, a C1-I0 alkoxycarbonyl group, a C1-HO alkylcarbonyl group (the C1.10 alkyl group, the C2-5 alkenyl group, the C2-6 alkynyl group, the Ci-10 alkoxy group, the Ci-10 alkylcarbonyloxy group, the Ci_10 alkoxycarbonyl group and the C1-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-Io alkoxy groups, C1-X0 alkylcarbonyl groups, C1-Io alkylcarbonyloxy groups, Ci_10 alkoxycarbonyl groups, C1-J-0 alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Cχ-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_10 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-e alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-10 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups) or a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-IL0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Ci-10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2_14 aryloxy groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
7) Compounds represented by the formula (1) according to 4) , 5) or 6) wherein A is CR37 (wherein R37 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2_6 alkynyl group) , a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-β alkynyl group or a C1-10 alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-5 alkenyl groups or one or two C2-6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-H0 alkoxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl . groups, nitro groups and cyano groups) , SO2R38, SOR38 or COR38 (wherein R38 is a hydroxyl group, a C1-X0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1.10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-O-0 alkoxy group may be substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups and cyano groups) , a C2-14 aryl group or a C2-I4 aryloxy group (the C2-I4 aryl group and the C2-I4 aryloxy group may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The terms in the respective substituents R37 and R38 are the same as those in the respective substituents R1 to R36.
8) Compounds represented by the formula (1) according to 3) or 6) wherein B is NR39 (wherein R39 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci_i0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-io alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci_i0 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-io alkoxy group, the Cx-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci_i0 alkylcarbonyl group may be substituted with one or more substituents selected from the group consisting of carboxyl groups, halogen atoms, nitro groups and cyano groups) , a C2-I4 aryl group or a C2-I4 aryloxy group (the C2-I4 aryl group and the C2-I4 aryloxy group may be substituted with one or more substituents selected from the group consisting of C1.6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups and halogen atoms)), tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The terms in the substituent R39 are the same as those in the respective substituents R1 to R36.
9) Compounds represented by the formula (1) according to 1) , 2) , 3) , 4) , 5) , 6) , 7) or 8) wherein L1 is a bond, tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
10) Compounds represented by the formula (1) according to l) , 2) , 3) , 4), 5) , 6) , I) 1 8) or 9) wherein L2 is a bond, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 11) Compounds represented by the formula (1) according to 1) , 2) , 3), 4) , 5) , 6) , 7) , 8), 9) or 10) wherein L3 is NR19 (wherein R19 is a hydrogen atom, a hydroxy1 group, a formyl group, a C2-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-I0 alkylcarbonyloxy group, a Ci-10 alkoxycarbonyl group, a Ci-10 alkylcarbonyl group (the C1-I0 alkyl group, the C2_6 alkenyl group, the C2_e alkynyl group, the C1-10 alkoxy group, the Ci-10 alkylcarbonyloxy group, the C1-X0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Cx-10 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C3._6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C3.-10 alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-X0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups)) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
12) The compounds according to 1) , 2), 3), 4) , 5), 6), 7) , 8), 9) or 10) wherein L3 is NH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
13) The compounds according to 1) , 2), 3), 4) , 5) , 6) , 7) , 8) , 9) or 10) wherein L3 is CH2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
14) The compounds according to 11) , 12) or 13) wherein R2 is a hydrogen atom, a C1-I0 alkyl group, a C2_6 alkenyl group, a C2-6 alkynyl group, a Ci-io alkoxy group (the Ci-I0 alkyl group, the C2-e alkenyl group, the C2-6 alkynyl group and the Ci-io alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Cx-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group or a C2-I4 aryloxy group (the C2-I4 aryl group and the C2.14 aryloxy group may be substituted with one or more Ci_6 alkyl groups (the CX-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
15) The compounds according to 11) , 12) or 13) wherein R2 is a hydrogen atom, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci_3 alkoxy group (the Ci-io alkyl group, the C2-e alkenyl group, the C2_6 alkynyl group and the Ci_3 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, phenyl groups and phenyloxyl groups (the phenyl groups and the phenyloxyl groups may be substituted with one or more Ci_s alkyl groups (the Ci.6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , a phenyl group or a phenyloxy group (the phenyl group and the phenyloxy group may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
16) The compounds according to 11), 12) or 13) wherein R2 is a hydrogen atom, a Ci-io alkyl group, a C2-β alkenyl group or a C2.6 alkynyl group (the C1-I0 alkyl group, the C2-6 alkenyl group and the C2.6 alkynyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci_10 alkylcarbonyloxy groups, C1.10 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups and protected hydroxyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 17) The compounds according to 11), 12) or 13) wherein R2 is a hydrogen atom or a Cx-5 alkyl group (the
Ci_6 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-C1-X0 alkylamino groups, hydroxyl groups and protected hydroxyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 18) The compounds according to 11) , 12) or 13) wherein R2 is a hydrogen atom or a C3.-3 alkyl group (the C1-3 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups and protected hydroxyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof .
19) The compounds according to 14) , 15) , 16) , 17) or 18) wherein R1 is a C2-14 aryl group (the C2.14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci-10 alkyl groups, C2-6 alkenyl groups, C2-6 alkynyl groups, C1-I0 alkoxy groups, Ci_10 alkylcarbonyl groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonyloxy groups (the Ci_i0 alkyl groups, the C2-6 alkenyl groups, the C2-S alkynyl groups and the Ci_i0 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-iQ alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci_10 alkylcarbonylamino groups, amino groups, mono- or di-Cx-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-I4 aryloxy groups (the C2.14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) , C2-I4 aryl groups, C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-έ alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of formyl groups, Ci-io alkyl groups, C2-β alkenyl groups, C2-β alkynyl groups and Ci-io alkylcarbonyl groups (the Cx-I0 alkyl groups, the C2-β alkenyl groups, the C2-6 alkynyl groups and the Ci-I0 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci_io alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 20) The compounds according to 14) , 15) , 16) , 17) or 18) wherein R1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C1-I0 alkyl groups, C2-6 alkenyl groups, C2-6 alkynyl groups, Ci_i0 alkoxy groups, Ci-10 alkylcarbonyl groups, C1-Xo alkoxycarbonyl groups, Ci-io alkylcarbonyloxy groups (the Ci-I0 alkyl groups, the C2-6 alkenyl groups, the C2-6 alkynyl groups, the C1-I0 alkoxy groups, the Ci_10 alkylcarbonyl groups, the C1-10 alkylcarbonyloxy groups and the Ci_i0 alkoxycarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-K5 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of formyl groups, C1-I0 alkyl groups, C2-6 alkenyl groups, C2-6 alkynyl groups and C1-I0 alkylcarbonyl groups (the C1-Io alkyl groups, the C2-6 alkenyl groups, the C2-6 alkynyl groups and the C1-10 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-H0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-I14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)))) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
21) The compounds according to 14) , 15) , 16) , 17) or 18) wherein R1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci_i0 alkyl groups, C2-6 alkenyl groups, C2.6 alkynyl groups, C1^10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkoxycarbonyl groups, Ci-lo alkylcarbonyloxy groups (the Ci-I0 alkyl groups, the C2-6 alkenyl groups, the C2-6 alkynyl groups, the Ci-lo alkoxy groups, the Ci-10 alkylcarbonyl groups, the Ci_i0 alkoxycarbonyl groups and the Ci-io alkylcarbonyloxy groups may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups and cyano groups) , C2-I4 aryl groups, C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of formyl groups, Ci-I0 alkyl groups, C2_6 alkenyl groups, C2-6 alkynyl groups and Ci-I0 alkylcarbonyl groups (the C1-I0 alkyl groups, the C2-6 alkenyl groups, the C2.6 alkynyl groups and the Ci-I0 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, cyano groups, hydroxyl groups and protected hydroxyl groups) ) ) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
22) The compounds according to 14) , 15) , 16) , 17) or 18) wherein R1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci_i0 alkyl groups, C2-β alkenyl groups, C2-β alkynyl groups, Ci-io alkoxy groups, Ci-io alkylcarbonyl groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonyloxy groups (the Ci-I0 alkyl groups, the C2-6 alkenyl groups, the C2-6 alkynyl groups, the Cx-I0 alkoxy groups, the Ci-I0 alkylcarbonyl groups, the Ci-I0 alkoxycarbonyl groups and the Ci-I0 alkylcarbonyloxy groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , thiol groups and amino groups (the thiol groups and the amino groups may be optionally- substituted with one or more substituents selected from the group consisting of formyl groups, Ci_i0 alkyl groups, C2-6 alkenyl groups, C2-6 alkynyl groups and Ci-I0 alkylcarbonyl groups (the Ci-I0 alkyl groups, the C2_6 alkenyl groups, the C2-6 alkynyl groups and the Ci-I0 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-X0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl group and the C2-I4 aryloxy group may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) ) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
23) The compounds according to 14) , 15) , 16) , 17) or 18) wherein R1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci-io alkyl groups, C2-6 alkenyl groups, C2-6 alkynyl groups, C1-X0 alkoxy groups, C1-X0 alkylcarbonyl groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonyloxy groups (the C1-I0 alkyl groups, the C2-6 alkenyl groups, the C2-6 alkynyl groups, the Ci-io alkoxy groups, the C1-I0 alkylcarbonyl groups, the C1-I0 alkoxycarbonyl groups and the C1-O-O alkylcarbonyloxy groups may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups and cyano groups) , C2-14 aryl groups, C2-14 aryloxy groups (the C2-.14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-S alkyl groups (the C1-6.alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) , thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of formyl groups, C1-10 alkyl groups, C2-6 alkenyl groups, C2-6 alkynyl groups and C1-10 alkylcarbonyl groups (the C1-10 alkyl groups, the C2-6 alkenyl groups, the C2-6 alkynyl groups and the C1-I0 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, cyano groups, hydroxyl groups and protected hydroxyl groups))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
24) The compounds according to 19) , 20) , 21), 22) or 23) wherein Y is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
25) The compounds according to 19), 20) , 21), 22) or 23) wherein Y is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 26) The compounds according to 24) or 25) wherein X is a hydroxyl group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 27) The compounds according to 24) , 25) or 26) wherein L4 is a bond, and R3 is an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a s-butyl group, a t- butyl group, a c-propyl group, a c-butyl group, a c- pentyl group, a c-hexyl group, an ethynyl group, a 1- propynyl group, a 2-propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a 1-methyl-2- butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3- butynyl group, a 3-methyl-1-butynyl group or any one of the following heterocyclic groups: N
V V ~V V" V" X> -U -Q d
Figure imgf000184_0001
(the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, Ci-10 alkoxycarbonyl groups, C1-10 alkyl groups, C2_10 alkenyl groups, C2-10 alkynyl groups, C2-S heterocyclic groups, C1-10 alkoxy groups, C1-X0 thioalkyl groups, C1-IL0 alkylcarbonyl groups, mono- or di- C1-10 alkylamino groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups and the following aryl groups and heterocyclic groups (the C1-10 alkyl groups, the C2-I0 alkenyl groups, the C2_10 alkynyl groups, the C2-9 heterocyclic groups, the C1-10 alkoxy groups, the C1-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-C1-10 alkylamino groups, the C1-10 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups, the C1-10 alkylcarbonylamino groups and the following aryl groups and heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) : Aryl groups: a phenyl group, thienyl groups (a thienyl groups (a 2-thienyl group and a 3-thienyl group) , furyl groups (a 2-furyl group and a 3-furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4- pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group) , a pyrazinyl group, pyrimidinyl group (a 2-pyrimidinyl group, a 4- pyrimidinyl group and a 5-pyrimidinyl group) , quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4- quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6- isoquinolyl group, a 7-isoquinolyl group and a 8- isoquinolyl group) ;
Heterocyclic groups: a 1, 3,4-oxadiazole group, a 1, 3,4-thiadiazole group, a 1, 2, 4-oxadiazole group, a 1, 2,4-thiadiazole group, a 1, 2, 5-oxadiazole group, a 1, 2, 5-thiadiazole group, a 1,2-oxazole group, a 1,2- thiazole group, a 1,3-oxazole group, a 1,3-thiazole group, a pyrrole group, an imidazole group and a pyrazole group) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
28) The compounds according to 24), 25) or 26) wherein L4 is a bond, and R3 is a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a n-butyl group, a s- butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1- butynyl group, a 2-butynyl group, a 3-butynyl group, a 1- pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a 1-methyl-2-butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3-butynyl group, a 3-methyl-1-butynyl group or any one of the following heterocyclic groups:
Figure imgf000187_0001
-^V JTv JiA ^ΓΛ XΓΛ NΓΛ VΓΛ
S^0 ~<N^O o^-N^O C> N N N 7- N O \
Figure imgf000187_0002
(the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups,- hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, C1-I0 alkoxycarbonyl groups, C1-I0 alkyl groups, C2-10 alkenyl groups, C2-10 alkynyl groups, C2-9 heterocyclic groups, C1-10 alkoxy groups, C1-10 thioalkyl groups, Ci-io alkylcarbonyl groups, mono- or di- Ci-io alkylamino groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylaminocarbonyl groups and C1-10 alkylcarbonylamino groups (the C1-10 alkyl groups, the C2-Io alkenyl groups, the C2_10 alkynyl groups, the C2-9 heterocyclic groups, the C1-10 alkoxy groups, the C1-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-C1-O-0 alkylamino groups, the Ci-io alkylcarbonyloxy groups, the Ci-io alkoxycarbonyl groups, the C1-10 alkylaminocarbonyl groups and the C1-10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of C2-14 aryl groups, hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
29) The compounds according to 24) , 25) or 26) wherein L4 is a bond, and R3 is a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a n-butyl group, a c- propyl group, a c-hexyl group, an ethynyl group, a 1- propynyl group, a 2-propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, C3..αo alkoxycarbonyl groups, Ci-I0 alkyl groups, C2-I0 alkenyl groups, C2-10 alkynyl groups, C2_9 heterocyclic groups, Ci-I0 alkoxy groups, Ci_i0 thioalkyl groups, Ci_i0 alkylcarbonyl groups, mono- or di- Ci-I0 alkylamino groups, Ci-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups and Ci-io alkylcarbonylamino groups (the Ci-io alkyl groups, the C2-I0 alkenyl groups, the C2-io alkynyl groups, the C2-9 heterocyclic groups, the Ci-io alkoxy groups, the Ci-I0 thioalkyl groups, the Ci_i0 alkylcarbonyl groups, the mono- or di-Ci_i0 alkylamino groups, the Ci-I0 alkylcarbonyloxy groups, the Ci-io alkoxycarbonyl groups and the Ci_i0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
30) The compounds according to 24) , 25) or 26) wherein L4 is a bond, and R3 is a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a n-butyl group, a c- propyl group, a c-hexyl group, an ethynyl group, a 1- propynyl group, a 2-propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH and Ci-io alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
31) The compounds according to 24) , 25) or 26) wherein L4 is a bond, and R3 is any one of the following heterocyclic groups: V V V V" V" X)N -Q -Q ^d
Figure imgf000191_0001
Figure imgf000191_0002
Figure imgf000191_0003
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, halogen atoms, nitro groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, phenyl groups, thienyl groups, pyridyl groups, furyl groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, - (C=O)CO2H, -CH2 (C=O) CO2H, -NH(C=O)CO2H, -NHS (=0)2NH2/ Ci_10 alkoxycarbonyl groups, Ci-io alkyl groups (the <-V10 alkyl groups may be substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, phenyl groups, 2-thienyl groups, 3-thienyl groups, 2- furyl groups, 3-furyl groups, 3-pyridazinyl groups, 4- pyridazinyl groups, 2-pyridyl groups, 3-pyridyl groups, 4-pyridyl groups, pyrazinyl groups, 2-pyrimidinyl groups, 4-pyrimidinyl groups, 5-pyrimidinyl groups, 1,3-oxazolyl groups, 1, 3-thiazolyl groups, pyrrolyl groups, imidazolyl groups, pyrazolyl groups, 2-quinolyl groups, 3-quinolyl groups, 4-quinolyl groups, 5-quinolyl groups, 6-quinolyl groups, 7-quinolyl groups, 8-quinolyl groups, 1- isoquinolyly groups, 3-isoquinolyly groups, 4- isoquinolyly groups, 5-isoquinolyly groups, 6- isoquinolyly groups, 7-isoquinolyly groups, 8- isoquinolyly groups, 1, 3,4-oxadiazole groups, 1,3,4- thiadiazole groups, 1,2,4-oxadiazole groups, 1,2,4- thiadiazole groups, 1,2, 5-oxadiazole groups, 1,2,5- thiadiazole groups, 1,2-oxazole groups, 1,2-thiazole groups and Ci-io alkylaminocarbonyl groups (the Ci-10 alkylaminocarbonyl groups may be substituted with one or more substituents selected from the group consisting of phenyl groups, 2-thienyl groups, 3-thienyl groups, 2- furyl groups, 3-furyl groups, 3-pyridazinyl groups, 4- pyridazinyl groups, 2-pyridyl groups, 3-pyridyl groups, 4-pyridyl groups, 2-quinolyl groups, 3-quinolyl groups, 4-quinolyl groups, 5-quinolyl groups, 6-quinolyl groups, 7-quinolyl groups, 8-quinolyl groups, 1-isoquinolyly groups, 3-isoquinolyly groups, 4-isoquinolyly groups, 5- isoquinolyly groups, 6-isoquinolyly groups, 7- isoquinolyly groups, 8-isoquinolyly groups, 1,3,4- oxadiazole groups, 1, 3, 4-thiadiazole groups, 1,2,4- oxadiazole groups, 1,2,4-thiadiazole groups, 1,2,5- oxadiazole groups, I72, 5-thiadiazole groups, 1,2-oxazole groups, 1, 2-thiazole groups, 1,3-oxazole groups, 1,3- thiazole groups, pyrrole groups, imidazole groups and pyrazole groups)), C2-io alkenyl groups, C2-I0 alkynyl groups, C2-9 heterocyclic groups, Ci-10 thioalkyl groups, Ci-io alkoxy groups, Ci-i0 alkylcarbonyl groups, Ci-i0 alkylaminocarbonyl groups, Ci_io dialkylaminocarbonyl groups, mono- or di-Ci-i0 alkylamino groups, Ci-io alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Cx-I0 alkylcarbonylamino groups (the Ci-i0 alkoxy groups, the Ci-I0 alkylcarbonyl groups, the Ci-I0 alkylaminocarbonyl groups, the Ci-io dialkylaminocarbonyl groups, the mono- or di-Ci-I0 alkylamino groups, the Ci_10 alkylcarbonyloxy groups, the Ci-I0 alkoxycarbonyl groups and the C1-I0 alkylcarbonylamino groups may be substituted with one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, phenyl groups, 2-thienyl groups, 3-thienyl groups, 2-furyl groups, 3-furyl groups, 3-pyridazinyl groups, 4-pyridazinyl groups, 2-pyridyl groups, 3-pyridyl groups, 4-pyridyl groups, 2-quinolyl groups, 3-quinolyl groups, 4-quinolyl groups, 5-quinolyl groups, 6-quinolyl groups, 7-quinolyl groups, 8-quinolyl groups, 1- isoquinolyly groups, 3-isoquinolyly groups, 4- isoquinolyly groups, 5-isoquinolyly groups, 6- isoquinolyly groups, 7-isoquinolyly groups, 8- isoquinolyly groups, 1,3,4-oxadiazole groups, 1,3,4- thiadiazole groups, 1, 2,4-oxadiazole groups, 1,2,4- thiadiazole groups, 1, 2, 5-oxadiazole groups, 1,2,5- thiadiazole groups, 1,2-oxazole groups, 1,2-thiazole groups, 1,3-oxazole groups, 1,3-thiazole groups, pyrrole groups, imidazole groups and pyrazole groups) , pyridylaminocarbonyl groups, phenyl groups, 2-thienyl groups, 3-thienyl groups, 2-furyl groups, 3-furyl groups, 3-pyridazinyl groups, 4-pyridazinyl groups, 2-pyridyl groups, 3-pyridyl groups; 4-pyridyl groups, 2-quinolyl groups, 3-quinolyl groups, 4-quinolyl groups, 5-quinolyl groups, 6-quinolyl groups, 7-quinolyl groups, 8-quinolyl groups, 1-isoquinolyly groups, 3-isoquinolyly groups, 4- isoquinolyly groups, 5-isoquinolyly groups, 6- isoquinolyly groups, 7-isoquinolyly groups, 8- isoquinolyly groups, 1,3,4-oxadiazole groups, 1,3,4- thiadiazole groups, 1,2,4-oxadiazole groups, 1,2,4- thiadiazole groups, 1,2,5-oxadiazole groups, 1,2,5- thiadiazole groups, 1,2-oxazole groups, 1,2-thiazole groups, 1,3-oxazole groups, 1,3-thiazole groups, pyrrole groups, imidazole groups and pyrazole groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
32) The compounds according to 24) , 25) or 26) wherein L4 is a bond, and R3 is any one of the following heterocyclic groups:
"Q ^) -Q s> x> -ώ 4N> -Cr
Figure imgf000195_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulf amoyl groups, cyano sulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, d_10 alkoxycarbonyl groups, Ci-io alkyl groups, C1-10 alkylcarbonyl groups, C1-I0 alkylsulfonyl groups, C1- 0 alkylaminosulfonyl groups, Ci-io alkylaminocarbonyl groups and Ci_i0 dialkylaminocarbonyl groups (the Ci-lo alkyl groups, the Ci-io alkylcarbonyl groups, the C1-Io alkylsulfonyl groups, the Ci-io alkylaminosulfonyl groups, the Ci-I0 alkylaminocarbonyl groups and the Ci-I0 dialkylaminocarbonyl groups may be substituted with one or more substituents selected from the group consisting of phenyl groups, thienyl groups, furyl groups, pyridyl groups, nitro groups, cyano groups, hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups and tetrazole groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
33) The compounds according to 24) , 25) or 26) wherein L4 is a bond, and R3 is any one of the following heterocyclic groups:
Figure imgf000196_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, C1-I0 alkoxycarbonyl groups, Ci-I0 alkyl groups, C2-I0 alkenyl groups, C2-I0 alkynyl groups, C2-9 heterocyclic groups, Ci-io alkoxy groups, C1-X0 thioalkyl groups, Ci-I0 alkylcarbonyl groups, mono- or di-Ci-xo alkylamino groups, Ci-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups and Ci_10 alkylcarbonylamino groups (the Ci-I0 alkyl groups, the C2-I0 alkenyl groups, the C2-I0 alkynyl groups, the C2_9 heterocyclic groups, the Ci-I0 alkoxy groups, the Ci-io thioalkyl groups, the Ci-io alkylcarbonyl groups, the mono- or di-Ci-I0 alkylamino groups, the Ci-I0 alkylcarbonyloxy groups, the Ci-I0 alkoxycarbonyl groups and the C1-I0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxy1 groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
34) The compounds according to 24) , 25) or 26) wherein L4 is a bond, and R3 is any one of the following heterocyclic groups:
Figure imgf000198_0001
(the above heterocyclic groups are optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH,
-OCH2OH, -NHCH2OH, -CH2CH2OH, C1-10 alkoxycarbonyl groups, methyl groups, ethyl groups, n-propyl groups, i-propyl groups, methylcarbonyl groups, ethylcarbonyl groups, n- propylcarbonyl groups, methylsulfonyl groups, ethylsulfonyl groups, n-propylsulfonyl groups, i- propylsulfonyl groups, methylaminosulfonyl groups, ethylaminosulfonyl groups, n-propylaminosulfonyl groups, i-propylaminosulfonyl groups, methylaminocarbonyl groups, ethylaminocarbonyl groups, n-propylaminocarbonyl groups, i-propylaminocarobnyl groups, c-propylaminocarobnyl groups and n-butylaminocarbonyl groups (the methyl groups, the ethyl groups, the n-propyl groups, the i- propyl groups, the methylcarbonyl groups, the ethylcarbonyl groups, the n-propylcarbonyl groups, the methylsulfonyl groups, the ethylsulfonyl groups, the n- propylsulfonyl groups, the i-propylsulfonyl groups, the methylaminosulfonyl groups, the ethylaminosulfonyl groups, the n-propylaminosulfonyl groups, the i- propylaminosulfonyl groups, the methylaminocarbonyl groups, the ethylaminocarbonyl groups, the n- propylaminocarbonyl groups, the i-propylaminocarobnyl groups, the c-propylaminocarobnyl groups and the n- butylaminocarbonyl groups may be substituted with one or more substituents selected from the group consisting of phenyl groups, thienyl groups, pyridyl groups and furyl groups)) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof . 35) The compounds according to 24) , 25) or 26) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a C1-10 alkylcarbonyloxy group, a Ci-10 alkoxycarbonyl group, a C1-I0 alkylcarbonyl group (the Ci-I0 alkyl group, the C2-β alkenyl group, the C2-β alkynyl group, the Ci_i0 alkoxy group, the Ci_i0 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Cx.6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, QL-IO alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_i4 aryl groups and C2_i4 aryloxy groups) ) , and R3 is an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a s-butyl group, a t-butyl group, a c- propyl group, a c-butyl group, a c-pentyl group, a c- hexyl group, an ethynyl group, a 1-propynyl group, a 2- propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a 1-methyl-2-butynyl group, a 1- methyl-3-butynyl group, a 2-methyl-3-butynyl group, a 3- methyl-1-butynyl group or any one of the following heterocyclic groups:
Figure imgf000201_0001
(the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group,, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the 1-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, C1-I0 alkoxycarbonyl groups, C1-I0 alkyl groups, C2-I0 alkenyl groups, C2_10 alkynyl groups, C2-9 heterocyclic groups, Ci-I0 alkoxy groups, Ci-I0 thioalkyl groups, Ci_i0 alkylcarbonyl groups, mono- or di- Ci-I0 alkylamino groups, C1-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups and C1-I0 alkylcarbonylamino groups (the Ci-I0 alkyl groups, the C2-I0 alkenyl groups, the C2-io alkynyl groups, the C2-9 heterocyclic groups, the Ci_i0 alkoxy groups, the C1-K) thioalkyl groups, the Ci-I0 alkylcarbonyl groups, the mono- or di-C1-O-0 alkylamino groups, the Ci-io alkylcarbonyloxy groups, the Ci-I0 alkoxycarbonyl groups and the Ci-I0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) : Aryl groups: a phenyl group, thienyl groups (a 2- thienyl group and a 3-thienyl group) , furyl groups (a 2- furyl group and a 3-furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4- pyridyl group) , quinolyl groups (a 2-quinolyl group, a 3- quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5- isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) ; Heterocyclic groups: a 1,3,4-oxadiazole group, a 1, 3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1, 2,4-thiadiazole group, a 1,2, 5-oxadiazole group, a 1, 2, 5-thiadiazole group, a 1,2-oxazole group and a 1,2- thiazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
36) The compounds according to 24) , 25) or 26) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-io alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-io alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-10 alkoxycarbonyl group, a Ci-iQ alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the Ci_10 alkylcarbonyloxy group, the C1-I0 alkoxycarbonyl group and the Cx-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Cx-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2_i4 aryloxy groups (the C2-i4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more C1.6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen atoms) , C2~β alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups)) , and R3 is a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a s-butyl group, a t- butyl group, a c-propyl group, a c-butyl group, a c- pentyl group, a c-hexyl group, an ethynyl group, a 1- propynyl group, a 2-propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a l-methyl-2- butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3- butynyl group, a 3-methyl-1-butynyl group or any one of the following heterocyclic groups: XJ O N
Figure imgf000205_0001
Figure imgf000205_0002
N=
"^ :N^° "^i^0
Figure imgf000205_0003
(the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, C1-I0 alkoxycarbonyl groups, Ci-I0 alkyl groups, C2-I0 alkenyl groups, C2-io alkynyl groups, C2_9 heterocyclic groups, C1-X0 alkoxy groups, Ci-io thioalkyl groups, Cχ-10 alkylcarbonyl groups, mono- or di- Ci-io alkylamino groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups and Ci-I0 alkylcarbonylami.no groups (the Ci-10 alkyl groups, the C2-10 alkenyl groups, the C2_10 alkynyl groups, the C2-9 heterocyclic groups, the C1-I0 alkoxy groups, the Ci-I0 thioalkyl groups, the Ci-I0 alkylcarbonyl groups, the mono- or di-C1-X0 alkylamino groups, the Ci-I0 alkylcarbonyloxy groups, the Ci-io alkoxycarbonyl groups and the C1-I0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) ) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 37) The compounds according to 24) , 25) or 26) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2_6 alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-β alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) ) , and R3 is a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a c-propyl group, a c- hexyl group, an ethynyl group, a 1-propynyl group, a 2- propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, Ci_10 alkoxycarbonyl groups, Ci-io alkyl groups, C2-I0 alkenyl groups, C2-I0 alkynyl groups, C2-9 heterocyclic groups, Ci-I0 alkoxy groups, Ci-io thioalkyl groups, Ci-io alkylcarbonyl groups, mono- or di-Ci-10 alkylamino groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups and Ci_i0 alkylcarbonylamino groups (the Ci-I0 alkyl groups, the C2-I0 alkenyl groups, the C2-I0 alkynyl groups, the C2-9 heterocyclic groups, the Ci-I0 alkoxy groups, the Ci-I0 thioalkyl groups, the Ci_i0 alkylcarbonyl groups, the mono- or di-C1-I0 alkylamino groups, the Ci_i0 alkylcarbonyloxy groups, the C1-I0 alkoxycarbonyl groups and the Ci-I0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 38) The compounds according to 24) , 25) or 26) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-IL0 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or. more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, Ci_i0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-X0 alkylcarbonyl amino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups)) , and R3 is a methyl group, an ethyl group, a n-propyl group, an i -propyl group, a n-butyl group, a c -propyl group, a c- hexyl group, an ethynyl group, a 1-propynyl group, a 2- propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the i -propyl group, the n-butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulf amoyl groups-, cyanosulf amoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH and C1-10 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 39.) The compounds according to 24), 25) or 26) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-io alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci_i0 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci_i0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-I0 alkoxy group, the C1-10 alkylcarbonyloxy group, the Ci-io alkoxycarbonyl group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Cχ_io alkoxycarbonyl groups, C1-X0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups)), and R3 is any one of the following heterocyclic groups:
^> ^} -Q -Q> -Q. *> l2
Figure imgf000212_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl . groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H,
-CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, Cα-10 alkoxycarbonyl groups, Ci-10 alkyl groups, C2.10 alkenyl groups, C2-Io alkynyl groups, C2.9 heterocyclic groups, Ci-I0 alkoxy groups, C1-I0 thioalkyl groups, C1-K3 alkylcarbonyl groups, mono- or di-C1-10 alkylamino groups, C1-I0 alkylcarbonylbxy groups, Ci-I0 alkoxycarbonyl groups and Ci-10 alkylcarbonylamino groups (the Ci-I0 alkyl groups, the C2-Io alkenyl groups, the C2-10 alkynyl groups, the C2-9 heterocyclic groups, the C1-10 alkoxy groups, the C1-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or (U-C1-10 alkylamino groups, the C1-10 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups and the C1-10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) ) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 40) The compounds according to 24) , 25) or 26) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2_e alkynyl group, a Ci-I0 alkoxy group, a Ci-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a Cx-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2_6 alkynyl group, the Ci-io alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Cx-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci_10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2_14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) ) , and R3 is any one of the following heterocyclic groups:
Figure imgf000215_0001
Figure imgf000215_0002
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH and C^10 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 41) The compounds according to 24) , 25) or 26) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-I0 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a C1-X0 alkylcarbonyl group (the Cx-I0 alkyl group, the C2-β alkenyl group, the C2-β alkynyl group, the Ci-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Cx-I0 alkoxycarbonyl group and the Cx-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2_i4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Cx-I0 alkyl groups (the Cx-X0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Cx_xo alkoxy groups, Cx-X0 alkylcarbonyl groups, Cx.xo alkylcarbonyloxy groups, Cx-X0 alkoxycarbonyl groups, Cx_xo alkylcarbonylamino groups, amino groups, mono- or di-Cx-X0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_X4 aryl groups and C2_X4 aryloxy groups) ) , and R3 is any one of the following heterocyclic groups :
Figure imgf000217_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H7 -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, C1-I0 alkoxycarbonyl groups, C1-X0 alkyl groups, C2-10 alkenyl groups, C2-I0 alkynyl groups, C2-9 heterocyclic groups, C1-I0 alkoxy groups, Ci_10 thioalkyl groups, C1-Ho alkylcarbonyl groups, mono- or di-C1-I0 alkylamino groups, C1-X0 alkylcarbonyloxy groups, C1-X0 alkoxycarbonyl groups and Ci_10 alkylcarbonylamino groups (the C1-I0 alkyl groups, the C2-10 alkenyl groups, the C2.10 alkynyl groups, the C2.9 heterocyclic groups, the C1-J-0 alkoxy groups, the Cχ-10 thioalkyl groups, the C1-I0 alkylcarbonyl groups, the mono- or di-Cχ-10 alkylamino groups, the C1-H-0 alkylcarbonyloxy groups, the C1-X0 alkoxycarbonyl groups and the Ci_10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 42) The compounds according to 24), 25) or 26) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a C1-I0 alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2_6 alkynyl group, the Ci-I0 alkoxy group, the Cx-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups (the C2-i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1-I0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-^0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2_i4 aryloxy groups) ) , and R3 is any one of the following heterocyclic groups:
Figure imgf000219_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH and Ci_10 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
43) The compounds according to 24) , 25) or 26) wherein L4 is NH, and R3 is an ethyl group, a n-propyl group, an i- propyl group, a n-butyl group, a s-butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a 1-pentynyl group, a 2- pentynyl group, a 4-pentynyl group, a 1-methyl-2-butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3-butynyl group, a 3-methyl-1-butynyl group or any one of the following heterocyclic groups:
Figure imgf000220_0001
Figure imgf000220_0002
(the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the 1-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH,
-NHCH2OH, -CH2CH2OH, C1-10 alkoxycarbonyl groups, Cx-I0 alkyl groups, C2-10 alkenyl groups, C2-10 alkynyl groups, C2_9 heterocyclic groups, C1-10 alkoxy groups, C1-10 thioalkyl groups, C1-10 alkylcarbonyl groups, mono- or di- C1-10 alkylamino groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups and the following aryl groups and heterocyclic groups (the C1-10 alkyl groups, the C2_lo alkenyl groups, the C2_10 alkynyl groups, the C2.9 heterocyclic groups, the Ci-I0 alkoxy groups, the C1-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-C1-10 alkylamino groups, the C1-10 alkylcarbonyloxy groups,- the C1-10 alkoxycarbonyl groups, the C1-I0 alkylcarbonylamino groups and the following aryl groups and heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) :
Aryl groups: a phenyl group, thienyl groups (a 2- thienyl group and a 3-thienyl group) , furyl groups (a 2- furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4- pyridyl group) , quinolyl groups (a 2-quinolyl group, a 3- quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5- isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) ;
Heterocyclic groups: a 1, 3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1, 2,4-oxadiazole group, a 1, 2, 4-thiadiazole group, a 1, 2, 5-oxadiazole group, a 1,2, 5-thiadiazole group, a 1,2-oxazole group and a 1,2- thiazole group) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof .
44) The compounds according to 24) , 25) or 26) wherein L4 is NH, and R3 is a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a n-butyl group, a s- butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1- butynyl group., a 2-butynyl group, a 3-butynyl group, a 1- pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a 1-methyl-2-butynyl group, a 1-methyl-3-butynyl group, a 2-methyl-3-butynyl group, a 3-methyl-1-butynyl group or any one of the following heterocyclic groups:
Figure imgf000223_0001
Figure imgf000223_0002
(the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the 1-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH,
-NHCH2OH, -CH2CH2OH, Ci_i0 alkoxycarbonyl groups, Ci-io alkyl groups, C2-10 alkenyl groups, C2_i0 alkynyl groups, C2-9 heterocyclic groups, Ci-I0 alkoxy groups, Ci_i0 thioalkyl groups, C1-10 alkylcarbonyl groups, mono- or di- Ci-io alkylamino groups, C1-10 alkylcarbonyloxy groups, C1-K3 alkoxycarbonyl groups and Ci_i0 alkylcarbonylamino groups (the Ci-io alkyl groups, the C2.10 alkenyl groups, the C2-10 alkynyl groups, the C2-9 heterocyclic groups, the Ci-I0 alkoxy groups, the C1-H-0 thioalkyl groups, the Ci-I0 alkylcarbonyl groups, the mono- or di-Ci_i0 alkylamino groups, the C1-O-0 alkylcarbonyloxy groups, the Ci-I0 alkoxycarbonyl groups and the Ci-I0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
45) The compounds according to 24) , 25) or 26) wherein L4 is NH, and R3 is a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a n-butyl group, a c- propyl group, a c-hexyl group, an ethynyl group, a 1- propynyl group, a 2-propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkyl groups, C2-I0 alkenyl groups, C2-I0 alkynyl groups, C2-9 heterocyclic groups, Ci_i0 alkoxy groups, Ci-m thioalkyl groups, Ci_i0 alkylcarbonyl groups, mono- or di- Ci-I0 alkylamino groups, Ci_i0 alkylcarbonyloxy groups, Ci-io alkoxycarbonyl groups and Ci-I0 alkylcarbonylamino groups (the Cx-I0 alkyl groups, the C2-I0 alkenyl groups, the C2-I0 alkynyl groups, the C2-9 heterocyclic groups, the Ci-I0 alkoxy groups, the Ci_i0 thioalkyl groups, the Ci-I0 alkylcarbonyl groups, the mono- or di-Ci-10 alkylamino groups, the C1-I0 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups and the C1-10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 46) The compounds according to 24) , 25) or 26) wherein L4 is NH, and R3 is a methyl group, an ethyl group, a n- propyl group, an i-propyl group, a n-butyl group, a c- propyl group, a c-hexyl group, an ethynyl group, a 1- propynyl group, a 2-propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH and C1^0 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
47) The compounds according to 24) , 25) or 26) wherein L' is NH, and R3 is any one of the following heterocyclic groups:
Figure imgf000227_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H,
-CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, C1-10 alkoxycarbonyl groups, C1.lo alkyl groups, C2-10 alkenyl groups, C2-I0 alkynyl groups, C2.9 heterocyclic groups, Cπ..^ alkoxy groups, Ci_i0 thioalkyl groups, C1-IL0 alkylcarbonyl groups, mono- or di-Ci-io alkylamino groups, C1-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups and C1-I0 alkylcarbonylamino groups (the C1-I0 alkyl groups, the C2-1Q alkenyl groups, the C2-io alkynyl groups, the C2-g heterocyclic groups, the Ci-10 alkoxy groups, the C1-I0 thioalkyl groups, the Ci_10 alkylcarbonyl groups, the mono- or di-C1-I0 alkylamino groups, the Ci-lo alkylcarbonyloxy groups, the C1.^ alkoxycarbonyl groups and the C1^10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) ) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 48) The compounds according to 24) , 25) or 26) wherein L4 is NH, and R3 is any one of the following heterocyclic groups:
Figure imgf000228_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH and C1-10 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
49) The compounds according to 24) , 25) or 26) wherein L4 is NH, and R3 is any one of the following heterocyclic groups:
Figure imgf000229_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkyl groups, C2-io alkenyl groups, C2-10 alkynyl groups, C2-g heterocyclic groups, C1-10 alkoxy groups, Ci_i0 thioalkyl groups, Ci-10 alkylcarbonyl groups, mono- or CU-C1-10 alkylamino groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups and C1-10 alkylcarbonylamino groups (the Ci_10 alkyl groups, the C2-Io alkenyl groups, the C2-I0 alkynyl groups, the C2_9 heterocyclic groups, the C1-10 alkoxy groups, the C1-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-C1-10 alkylamino groups, the Cx-10 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups and the C1-10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
50) The compounds according to 24) , 25) or 26) wherein L4 is NH, and R3 is any one of the following heterocyclic groups :
Figure imgf000231_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH and Ci-I0 alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 51) The compounds according to 24) , 25) or 26) wherein L4 is an oxygen atom or a sulfur atom, and R3 is an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a s-butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 4- pentynyl group, a 1-methyl-2-butynyl group, a l-methyl-3- butynyl group, a 2-methyl-3-butynyl group, a 3-methyl-1- butynyl group or any one of the following heterocyclic groups:
Figure imgf000232_0001
(the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1- propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxy1 groups; amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxy-carbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, C1-X0 alkoxycarbonyl groups, C1-10 alkyl groups, C2-10 alkenyl groups, C2-10 alkynyl groups, C2-9 heterocyclic groups, C1-10 alkoxy groups, C1-10 thioalkyl groups, C1-10 alkylcarbonyl groups, mono- or di- C1-10 alkylamino groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups and the following aryl groups and heterocyclic groups (the C1-10 alkyl groups, the C2-10 alkenyl groups, the C2-10 alkynyl groups, the C2-9 heterocyclic groups, the C1-10 alkoxy groups, the C1-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-C1-10 alkylamino groups, the C1-10 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups, the C1-10 alkylcarbonylamino groups and the following aryl groups and heterocyclic groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) :
Aryl groups: a phenyl group, thienyl groups (a 2- thienyl group and a 3-thienyl group) , furyl groups (a 2- furyl group and a 3-furyl group) , pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group) , pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4- pyridyl group), quinolyl groups (a 2-quinolyl group, a 3- quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5- isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) ;
Heterocyclic groups: a 1,3,4-oxadiazole group, a 1, 3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1, 2,4-thiadiazole group, a 1,2, 5-oxadiazole group, a
1, 2, 5-thiadiazole group, a 1,2-oxazole group and a 1,2- thiazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 52) The compounds according to 24) , 25) or 26) wherein L4 is an oxygen atom or a sulfur atom, and R3 is a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a s-butyl group, a t-butyl group, a c-propyl group, a c-butyl group, a c-pentyl group, a c- hexyl group, an ethynyl group, a 1-propynyl group, a 2- propynyl group, a 1-butynyl group, a 2-butynyl group, a 3-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 4-pentynyl group, a 1-methyl-2-butynyl group, a 1- methyl-3-butynyl group, a 2-methyl-3-butynyl group, a 3- methyl-1-butynyl group or any one of the following heterocyclic groups:
Figure imgf000235_0001
Figure imgf000235_0002
(the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n-butyl group, the s-butyl group, the t-butyl group, the c-propyl group, the c-butyl group, the c-pentyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group, the 1-butynyl group, the 2-butynyl group, the 3-butynyl group, the 1- pentynyl group, the 2-pentynyl group, the 4-pentynyl group, the 1-methyl-2-butynyl group, the l-methyl-3- butynyl group, the 2-methyl-3-butynyl group, the 3- methyl-1-butynyl group and the above heterocyclic groups may be optionally substituted with one or more substituents selected' from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, C1-X0 alkoxycarbonyl groups, C1-10 alkyl groups, C2-10 alkenyl groups, C2-10 alkynyl groups, C2-9 heterocyclic groups, C1.10 alkoxy groups, C1-10 thioalkyl groups, C1-10 alkylcarbonyl groups, mono- or di- C1.io alkylamino groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups and C1-10 alkylcarbonylamino groups (the C1-10 alkyl groups, the C2-io alkenyl groups, the C2-10 alkynyl groups, the C2_9 heterocyclic groups, the C1-10 alkoxy groups, the C1-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-C1-10 alkylamino groups, the C1-10 alkylcarbonyloxy groups, the C1-I0 alkoxycarbonyl groups and the C1-10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 53) The compounds according to 24) , 25) or 26) wherein L4 is an oxygen atom or a sulfur atom, and R3 is a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a c-propyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the n- butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, Ci-io alkoxycarbonyl groups, Ci-io alkyl groups, C2-I0 alkenyl groups, C2-io alkynyl groups, C2_9 heterocyclic groups, Ci_i0 alkoxy groups, C1-I0 thioalkyl groups, Ci-I0 alkylcarbonyl groups, mono- or di- Ci-I0 alkylamino groups, Ci-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups and Ci_io alkylcarbonylamino groups (the Ci-I0 alkyl groups, the C2_i0 alkenyl groups, the C2-I0 alkynyl groups, the C2_9 heterocyclic groups, the Ci-I0 alkoxy groups, the Ci-io thioalkyl groups, the Ci-io alkylcarbonyl groups, the mono- or di-Ci-lo alkylamino groups, the Ci-10 alkylcarbonyloxy groups, the Ci-io alkoxycarbonyl groups and the Ci-io alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) ) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 54) The compounds according to 24) , 25) or 26) wherein L4 is an oxygen atom or a sulfur atom, and R3 is a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a n-butyl group, a c-propyl group, a c-hexyl group, an ethynyl group, a 1-propynyl group, a 2-propynyl group or a 1-butynyl group (the methyl group, the ethyl group, the n-propyl group, the ir-propyl group, the n- butyl group, the c-propyl group, the c-hexyl group, the ethynyl group, the 1-propynyl group, the 2-propynyl group and the 1-butynyl group may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH and Ci-io alkoxycarbonyl groups) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
55) The compounds according to 24) , 25) or 26) wherein L4 is an oxygen atom or a sulfur atom, and R3 is any one of the' following heterocyclic groups:
Figure imgf000239_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H,
-CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, Ci-10 alkoxycarbonyl groups, C1-K3 alkyl groups, C2-10 alkenyl groups, C2-].o alkynyl groups, C2-9 heterocyclic groups, Ci-10 alkoxy groups, Ci_i0 thioalkyl groups, C1-K) alkylcarbonyl groups, mono- or di-Ci_io alkylamino groups, C1-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups and Ci-I0 alkylcarbonylamino groups (the C1-I0 alkyl groups, the C2-10 alkenyl groups, the C2_10 alkynyl groups, the C2.9 heterocyclic groups, the C1-K5 alkoxy groups, the Ci_i0 thioalkyl groups, the C1-I0 alkylcarbonyl groups, the mono- or di-C1-I0 alkylamino groups, the Ci_i0 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups and the Cx-10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups) ) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof, 56) The compounds according to 24) , 25) or 26) wherein L4 is an oxygen atom or a sulfur atom, and R3 is any one of the following heterocyclic groups:
Figure imgf000240_0001
Figure imgf000240_0002
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups , cyanocarbamoyl groups , sulfamoyl groups , hydroxysulf amoyl groups , cyanosulf amoyl groups , tetrazole groups , -CH2CO2H, -OCH2CO2H, -NHCH2CO2H7 -CH2CH2CO2H, -CH2OH , -OCH2OH, -NHCH2OH, -CH2CH2OH and Ci_i0 alkoxycarbonyl groups ) , tautomers , prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof .
57 ) The compounds according to 24 ) , 25 ) or 26 ) wherein L4 is an oxygen atom or a sulfur atom, and R3 is any one of the following heterocyclic groups :
Figure imgf000241_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H,
-CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, Cx-I0 alkoxycarbonyl groups, C1-X0 alkyl groups, C2.10 alkenyl groups, C2.10 alkynyl groups, C2.9 heterocyclic groups, C1.10 alkoxy groups, Ci_i0 thioalkyl groups, Cx.10 alkylcarbonyl groups, mono- or di-Ci_i0 alkylamino groups, C1-X0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups and Cχ.lo alkylcarbonylamino groups (the C1-X0 alkyl groups, the C2-;LO alkenyl groups, the C2-10 alkynyl groups, the C2-g heterocyclic groups, the C1-I0 alkoxy groups, the Cχ.lo thioalkyl groups, the C1-X0 alkyLcarbonyl groups, the mono- or di-Ci-io alkylamino groups, the Cχ.lo alkylcarbonyloxy groups, the C1-X0 alkoxycarbonyl groups and the C1-I0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, carboxyl groups, carbamoyl groups, sulfonic acid groups and sulfamoyl groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
58) The compounds according to 24) , 25) or 26) wherein L4 is an oxygen atom or a sulfur atom, and R3 is any one of the following heterocyclic groups :
Figure imgf000242_0001
(the above heterocyclic groups may be optionally substituted with one or more substituents selected from the groups consisting of hydroxyl groups, amino groups, thiol groups, carboxyl group, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, tetrazole groups, -CH2CO2H, -OCH2CO2H, -NHCH2CO2H, -CH2CH2CO2H, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH and Ci-10 alkoxycarbonyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. 59) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 1 denote the flowing substituents.
Figure imgf000244_0001
TABLE 1
No A B R1 L1 R2 L3 Y L4 R3 X
1 N NMe QIa a bond Me a bond NH S NH Q3a OH
2 N NMe QIa a bond Me a bond NH S NH Q3b OH
3 N NMe QIa a bond Me a bond NH S NH Q3c OH
4 N NMe QIa a bond Me a bond NH S a bond Q3a OH
5 N NMe QIa a bond Me a bond NH S a bond Q3b OH
6 N NMe QIa a bond Me a bond NH S a bond Q3c OH 7 N NMe QIa a bond Me a bond NH 0 NH Q3a OH
8 N NMe QIa a bond Me a bond NH 0 NH Q3b OH
9 N NMe QIa a bond Me a bond NH 0 NH Q3c OH 10 N NMe QIa a bond Me a bond NH 0 a bond Q3a OH 11 N NMe QIa a bond Me a bond 'NH 0 a bond Q3b OH
12 N NMe QIa a bond Me a bond NH 0 a bond Q3c OH
13 N NMe QIa a bond H a bond NH S NH Q3a OH
14 N NMe QIa a bond H a bond NH S NH Q3b OH
15 N NMe QIa a bond H a bond NH S NH Q3c OH 16 N NMe QIa a bond H a bond NH S a bond Q3a OH
17 N NMe QIa a bond H a bond NH S a bond Q3b OH
18 N NMe QIa a bond H a bond NH S a bond Q3c OH
19 N NMe QIa a bond H a bond NH 0 NH Q3a OH
20 N NMe QIa a bond H a bond NH 0 NH Q3b OH 21 N NMe QIa a bond H a bond NH 0 NH Q3c OH
22 N NMe QIa a bond H a bond NH 0 a bond Q3a OH
23 N NMe QIa a bond H a bond NH 0 a bond Q3b OH
24 N NMe QIa a bond H a bond NH 0 a bond Q3c OH
25 N NMe QIb a bond Me a bond NH S NH Q3a OH 26 N NMe QIb a bond Me a bond NH S NH Q3b OH
27 N NMe QIb a bond Me a bond NH S NH Q3c OH
28 N NMe QIb a bond Me a bond NH S a bond Q3a OH
29 N NMe QIb a bond Me a bond NH S a bond Q3b OH
30 N NMe QIb a bond Me a bond NH S a bond Q3c OH 31 N NMe QIb a bond Me a bond NH 0 NH Q3a OH
32 N NMe QIb a bond Me a bond NH 0 NH Q3b OH
33 N NMe QIb a bond Me a bond NH 0 NH Q3c OH
34 N NMe QIb a bond Me a bond NH 0 a bond Q3a OH
35 N NMe QIb a bond Me a bond NH 0 a bond Q3b OH 36 N NMe QIb a bond Me a bond NH 0 a bond Q3c OH
37 N NMe QIb a bond H a bond NH S NH Q3a OH
38 N NMe QIb a bond H a bond NH S NH Q3b OH
39 N NMe QIb a bond H a bond NH S NH Q3c OH
40 N NMe QIb a bond H a bond NH S a bond Q3a OH 41 N NMe QIb a bond H a bond NH S a bond Q3b OH
42 N NMe QIb a bond H a bond NH S a bond Q3c OH 43 N NMe QIb a bond H a bond NH 0 NH Q3a OH
44 N NMe QIb a bond H a bond NH 0 NH Q3b OH
45 N NMe QIb a bond H a bond NH 0 NH Q3c OH
46 N NMe QIb a bond H a bond NH 0 a bond Q3a OH 47 N NMe QIb a bond H a bond NH 0 a bond Q3b OH
48 N NMe QIb a bond H a bond NH 0 a bond Q3c OH
49 N NMe QIc a bond Me a bond NH S NH Q3a OH
50 N NMe QIc a bond Me a bond NH S NH Q3b OH
51 N NMe QIc a bond Me a bond NH S NH Q3c OH 52 N NMe QIc a bond Me a bond NH S a bond Q3a OH
53 N NMe QIc a bond Me a bond NH S a bond Q3b OH
54 N NMe QIc a bond Me a bond NH S a bond Q3c OH
55 N NMe QIc a bond Me a bond NH 0 NH Q3a OH
56 N NMe QIc a bond Me a bond NH 0 NH Q3b OH 57 N NMe QIc a bond Me a bond NH 0 NH Q3c OH
58 N NMe QIc a bond Me a bond NH 0 a bond Q3a OH
59 N NMe QIc a bond Me a bond NH 0 a bond Q3b OH
60 N NMe QIc a bond Me a bond NH 0 a bond Q3c OH
61 N NMe QIc a bond H a bond NH S NH Q3a OH 62 N NMe QIc a bond H a bond NH S NH Q3b OH
63 N NMe QIc a bond H a bond NH S NH Q3c OH
64 N NMe QIc a bond H a bond NH S a bond Q3a OH
65 N NMe QIc a bond H a bond NH S a bond Q3b OH
66 N NMe QIc a bond H a bond NH S a bond Q3c OH 67 N NMe QIc a bond H a bond NH 0 NH Q3a OH
68 N NMe QIc a bond H a bond NH 0 NH Q3b OH
69 N NMe QIc a bond H a bond NH 0 NH Q3c OH
70 N NMe QIc a bond H a bond NH 0 a bond Q3a OH
71 N NMe QIc a bond H a bond NH 0 a bond Q3b OH 72 N NMe QIc a bond H a bond NH 0 a bond Q3c OH
73 N NMe QId a bond Me a bond NH S NH Q3a OH
74 N NMe QId a bond Me a bond NH S NH Q3b OH
75 N NMe QId a bond Me a bond NH S NH Q3c OH
76 N NMe QId a bond Me a bond NH S a bond Q3a OH 77 N NMe QId a bond Me a bond NH S a bond Q3b OH
78 N NMe QId a bond Me a bond NH S a bond Q3c OH 79 N NMe QId a bond Me a bond NH 0 NH Q3a OH
80 N NMe QId a bond Me a bond NH 0 NH Q3b OH
81 N NMe QId a bond Me a bond NH 0 NH Q3c OH
82 N NMe QId a bond Me a bond NH 0 a bond Q3∑i OH
83 N NMe QId a bond Me a bond 'NH 0 a bond Q3t ) OH
84 N NMe QId a bond Me a bond NH 0 a bond Q3c : OH
85 N NMe QId a bond H a bond NH S NH Q3a OH
86 N NMe QId a bond H a bond NH S NH Q3b OH
87 N NMe QId a bond H a bond NH S NH Q3c OH
88 N NMe QId a bond H a bond NH S a bond Q3a OH
89 N NMe QId a bond H a bond NH S a bond Q3b OH
90 N NMe QId a bond H a bond NH S a bond Q3c OH
91 N NMe QId a bond H a bond NH 0 NH Q3a OH
92 N NMe QId a bond H a bond NH 0 NH Q3b OH
93 N NMe QId a bond H a bond NH 0 NH Q3c OH
94 N NMe QId a bond H a bond NH 0 a bond Q3a OH
95 N Me QId a bond H a bond NH 0 a bond Q3b OH
96 N NMe QId a bond H a bond NH 0 a bond Q3c OH
97 N NMe QIe a bond Me a bond NH S NH Q3a OH
98 N NMe QIe a bond Me a bond NH S NH Q3b OH
99 N NMe QIe a bond Me a bond NH S NH Q3c OH
100 N NMe QIe a bond Me a bond NH S a bond Q3a OH
101 N NMe QIe a bond Me a bond NH S a bond Q3b OH
102 N NMe QIe a bond Me a bond NH S a bond Q3c OH
103 N NMe QIe a bond Me a bond NH 0 NH Q3a OH
104 N NMe QIe a bond Me a bond NH 0 NH Q3b OH
105 N NMe QIe a bond Me a bond NH 0 NH Q3c OH
106 N NMe QIe a bond Me a bond NH 0 a bond Q3a OH
107 N NMe QIe a bond Me a bond NH 0 a bond Q3b OH
108 N NMe QIe a bond Me a bond NH 0 a bond Q3c OH
109 N NMe QIe a bond H a bond NH S NH Q3a OH
110 N NMe QIe a bond H a bond NH S NH Q3b OH
111 N NMe QIe a bond H a bond NH S NH Q3c OH
112 N NMe QIe a bond H a bond NH S a bond Q3a OH
113 N NMe QIe a bond H a bond NH S a bond Q3b OH
114 N NMe QIe a bond H a bond NH S a bond Q3c OH 115 N Me QIe a bond H a bond NH 0 NH Q3a OH
116 N NMe QIe a bond H a bond NH 0 NH Q3b OH
117 N NMe QIe a bond H a bond NH 0 NH Q3c OH
118 N NMe QIe a bond H a bond NH 0 a bond Q3a OH 119 N NMe QIe a bond H a bond ' NH 0 a bond Q3b OH
120 N NMe QIe a bond H a bond NH 0 a bond Q3c OH
121 N NMe QIf a bond Me a bond NH S NH Q3a OH
122 N NMe QIf a bond Me a bond NH S NH Q3b OH
123 N NMe QIf a bond Me a bond NH S NH Q3c OH 124 N NMe QIf a bond Me a bond NH S a bond Q3a OH
125 N NMe QIf a bond Me a bond NH S a bond Q3b OH
126 N NMe QIf a bond Me a bond NH S a bond Q3c OH
127 N NMe QIf a bond Me a bond NH 0 NH Q3a OH
128 N NMe QIf a bond Me a bond NH 0 NH Q3b OH 129 N NMe QIf a bond Me a bond NH 0 NH Q3c OH
130 N NMe QIf a bond Me a bond NH 0 a bond Q3a OH
131 N NMe QIf a bond Me a bond NH 0 a bond Q3b OH
132 N NMe QIf a bond Me a bond NH 0 a bond Q3c OH
133 N NMe QIf a bond H a bond NH S NH Q3a OH 134 N NMe QIf a bond H a bond NH S NH Q3b OH
135 N NMe QIf a bond H a bond NH S NH Q3c OH
136 N NMe QIf a bond H a bond NH S a bond Q3a OH
137 N NMe QIf a bond H a bond NH S a bond Q3b OH
138 N NMe QIf a bond H a bond NH S a bond Q3c OH 139 N NMe QIf a bond H a bond NH 0 NH Q3a OH
140 N NMe QIf a bond H a bond NH 0 NH Q3b OH
141 N NMe QIf a bond H a bond NH 0 NH Q3c OH
142 N NMe QIf a bond H .a bond NH 0 a bond Q3a OH
143 N NMe QIf a bond H a bond NH 0 a bond Q3b OH 144 N NMe QIf a bond H a bond NH 0 a bond Q3c OH
145 N NMe QIg a bond Me a bond NH S NH Q3a OH
146 N NMe QIg a bond Me a bond NH S NH Q3b OH
147 N NMe QIg a bond Me a bond NH S NH Q3c OH
148 N NMe QIg a bond Me a bond NH S a bond Q3a OH 149 N NMe QIg a bond Me a bond NH S a bond Q3b OH
150 N NMe QIg a bond Me a bond NH S a bond Q3c OH 151 N NMe QIg a bond Me a bond NH 0 NH Q3a OH
152 N NMe Qig a bond Me a bond NH 0 NH Q3b OH
153 N NMe QIg a bond Me a bond NH 0 NH Q3c OH
154 N NMe Qig a bond Me a bond NH 0 a bond Q3a . OH
155 N NMe Qig a bond Me a bond NH 0 a bond Q3b OH
156 N NMe Qig a bond Me a bond NH 0 a bond Q3c OH
157 N NMe Qig a bond H a bond NH S NH Q3a OH
158 N NMe Qig a bond H a bond NH S NH Q3b OH
159 N NMe Qig a bond H a bond NH S NH Q3c OH
160 N NMe QIg a bond H a bond NH S a bond Q3a OH
161 N NMe Qig a bond H a bond NH S a bond Q3b OH
162 N NMe Qig a bond H a bond NH S a bond Q3c OH
163 N NMe Qig a bond H a bond NH 0 NH Q3a OH
164 N NMe Qig a bond H a bond NH 0 NH Q3b OH
165 N NMe Qig a bond H a bond NH 0 NH Q3c OH
166 N NMe Qig a bond H a bond NH 0 a bond Q3a OH
167 N NMe Qig a bond H a bond NH 0 a bond Q3b OH
168 N NMe QIg a bond H a bond NH 0 a bond Q3c OH
169 N NMe QIh a bond Me a bond NH S NH Q3a OH
170 N NMe QIh a bond Me a bond NH S NH Q3b OH
171 N NMe QIh a bond Me a bond NH S NH Q3c OH
172 N NMe QIh a bond Me a bond NH S a bond Q3a OH
173 N NMe QIh a bond Me a bond NH S a bond Q3b OH
174 N NMe QIh a bond Me a bond NH S a bond Q3c OH
175 N NMe QIh a bond Me a bond NH 0 NH Q3a OH
176 N NMe QIh a bond Me a bond NH 0 NH Q3b OH
177 N NMe QIh a bond Me a bond NH 0 NH Q3c OH
178 N NMe QIh a bond Me. a bond NH 0 a bond Q3a OH
179 N NMe QIh a bond Me a bond NH 0 a bond Q3b OH
180 N NMe QIh a bond Me a bond NH 0 a bond Q3c OH
181 N NMe QIh a bond H a bond NH S NH Q3a i OH
182 N NMe QIh a bond H a bond NH S NH Q3b i OH
183 ' N NMe QIh a bond H a bond NH S NH Q3c i OH
184 N NMe QIh a bond H a bond NH S a bond Q3a OH
185 N NMe QIh a bond H a bond NH S a bond Q3b OH
186 N NMe QIh a bond H a bond NH S a bond 03c OH 187 N NMe QIh a bond H a bond NH 0 NH Q3a OH
188 N NMe QIh a bond H a bond NH 0 NH Q3b OH
189 N NMe QIh a bond H a bond NH 0 NH Q3c OH
190 N NMe QIh a bond H a bond NH 0 a bond Q3a OH
191 N NMe QIh a bond H a bond NH 0 a bond Q3b OH
192 N NMe QIh a bond H a bond NH 0 a bond Q3c OH
193 N N NMMee Q QIIii a bond Me a bond NH S NH Q3a OH
194 N N NMMee Q QIIii a bond Me a bond NH S NH Q3b OH
195 N N NMMee Q QIIii a bond Me a bond NH S NH Q3c OH 1 19966 N N N NMMee Q QIIii a bond Me a bond NH S a bond I Q3a OH
197 N N NMMee Q QIIii a bond Me a bond NH S a bond [ Q3b OH
198 N N NMMee Q QIIii a bond Me a bond NH S a bond 1 Q3c OH
199 N N NMMee Q QIIii a bond Me a bond NH 0 NH Q3a OH
200 N N NMMee Q QIIii a bond Me a bond NH 0 NH Q3b OH 2 20011 N N N NMMee Q QIIii a bond Me a bond NH 0 NH Q3c OH
202 N N NMMee Q QIIii a bond Me a bond NH 0 a bond . Q3a OH
203 N N NMMee Q QIIii a bond Me a bond NH 0 a bondi Q3b OH
204 N N NMMee Q QIIii a bond Me a bond NH 0 a bond ! Q3c OH
205 N N NMMee Q QIIii a ' bond H a bond NH S NH Q3a ( DH 2 20066 N N N NMMee Q QIIii a bond H a bond NH S NH Q3b ( DH
207 N N NMMee Q QIIii a bond H a bond NH S NH Q3c ( DH
208 N N NMMee Q QIIii a bond H a bond NH S a bond Q3a OH
209 N N NMMee Q QIIii a bond H a bond NH S a bond Q3b OH
210 N N NMMee Q QIIii a bond H a bond NH S a bond Q3c OH 2 21111 N N N NMMee Q QIIii a bond H a bond NH 0 NH Q3a ( DH
212 N N NMMee Q QIIii a bond H a bond NH 0 NH Q3b ( DH
213 N N NMMee Q QIIii a bond H a bond NH 0 NH Q3c ( DH
214 N N NMMee Q QIIii a bond H .a bond NH 0 a bond Q3a OH
215 N N NMMee Q QIIii a bond H a bond NH 0 a bond Q3b OH 2 21166 N N N NMMee Q QIIii a bond H a bond NH 0 a bond Q3c OH
217 N N NMMee Q QIIjj a bond Me a bond NH S NH Q3a OH
218 N N NMMee Q QIIjj a bond Me a bond NH S NH Q3b OH
219 N N NMMee Q QIIjj a bond Me a bond NH S NH Q3c OH
220 N N NMMee Q QIIjj a bond Me a bond NH S a bond Q3a OH 2 22211 N N N NMMee Q QIIjj a bond Me a bond NH S a bond Q3b OH
222 N N NMMee Q QIIjj a bond Me a bond NH S a bond Q3c OH 223 N NMe QIj a bond Me a bond NH 0 ' NH Q3a OH
224 N NMe QIj a bond Me a bond NH 0 NH Q3b OH
225 N NMe QIj a bond Me a bond NH 0 NH Q3c OH
226 N NMe QIj a bond Me a bond NH 0 a bond Q3a OH 227 N NMe QIj a bond Me a bond NH 0 a bond Q3b OH
228 N NMe QIj a bond Me a bond NH 0 a bond Q3c OH
229 N NMe QIj a bond H a bond NH S NH Q3a OH
230 N NMe QIj a bond H a bond NH S NH Q3b OH
231 N NMe QIj a bond H a bond NH S NH Q3c OH 232 N NMe QIj a bond H a bond NH S a bond Q3a OH
233 N NMe QIj a bond H a bond NH S a bond Q3b OH
234 N NMe QIj a bond H a bond NH S a bond Q3c OH
235 N NMe QIj a bond H a bond NH 0 NH Q3a OH
236 N NMe QIj a bond H a bond NH 0 NH Q3b OH 237 N NMe QIj a bond H a bond NH 0 NH Q3c OH
238 N NMe QIj a bond H a bond NH 0 a bond Q3a OH
239 N NMe QIj a bond H a bond NH 0 a bond Q3b OH
240 N NMe QIj a bond H a bond NH 0 a bond Q3c OH
241 N NEt QIa a bond Me a bond NH S NH Q3a OH 242 N NEt QIa a bond Me a bond NH S NH Q3b OH
243 N NEt QIa a bond Me a bond NH S NH Q3c OH
244 N NEt QIa a bond Me a bond NH S a bond Q3a OH
245 N NEt QIa a bond Me a bond NH S a bond Q3b OH
246 N NEt QIa a bond Me a bond NH S a bond Q3c OH 247 N NEt QIa a bond Me a bond NH 0 NH Q3a OH
248 N NEt QIa a bond Me a bond NH 0 NH Q3b OH
249 N NEt QIa a bond Me a bond NH 0 NH Q3c OH
250 N NEt QIa a bond Me. a bond NH 0 a bond Q3a OH
251 N NEt QIa a bond Me a bond NH 0 a bond Q3b OH 252 N NEt QIa a bond Me a bond NH 0 a bond Q3c OH
253 N NEt QIa a bond H a bond NH S NH Q3a OH
254 N NEt QIa a bond H a bond NH S NH Q3b OH
255 'N NEt QIa a bond H a bond NH S NH Q3c OH
256 N NEt QIa a bond H a bond NH S a bond Q3a OH 257 N NEt QIa a bond H a bond NH S a bond Q3b OH
258 N NEt QIa a bond H a bond NH S a bond Q3c OH 259 N NEt QIa a bond H a bond NH 0 NH Q3a OH
260 N NEt QIa a bond H a bond NH 0 NH Q3b OH
261 N NEt QIa a bond H a bond NH 0 NH Q3c OH
262 N NEt QIa a bond H a bond NH 0 a bond Q3a OH 263 N NEt QIa a bond H a bond NH 0 a bond Q3b OH
264 N NEt QIa a bond H a bond NH 0 a bond Q3c OH
265 N NEt QIb a bond Me a bond NH S NH Q3a OH
266 N NEt QIb a bond Me a bond NH S NH Q3b OH
267 N NEt QIb a bond Me a bond NH S NH Q3c OH 268 N NEt QIb a bond Me a bond NH S a bond Q3a OH
269 N NEt QIb a bond Me a bond NH S a bond Q3b OH
270 N NEt QIb a bond Me a bond NH S a bond Q3c OH
271 N NEt QIb a bond Me a bond NH 0 NH Q3a OH
272 N NEt QIb a bond Me a bond NH 0 NH Q3b OH 273 N NEt QIb a bond Me a bond NH 0 NH Q3c OH
274 N NEt QIb a bond Me a bond NH 0 a bond Q3a OH
275 N NEt QIb a bond Me a bond NH 0 a bond Q3b OH
276 N NEt QIb a bond Me a bond NH 0 a bond Q3c OH
277 N NEt QIb a bond H a bond NH S NH Q3a OH 278 N NEt QIb a bond H a bond NH S -NH Q3b OH
279 N NEt QIb a bond H a bond NH S NH Q3c OH
280 N NEt QIb a bond H a bond NH S a bond Q3a OH
281 N NEt QIb a bond H a bond NH S a bond Q3b OH
282 N NEt QIb a bond H a bond NH S a bond Q3c OH 283 N NEt QIb a bond H a bond NH 0 NH Q3a OH
284 N NEt QIb a bond H a bond NH 0 NH Q3b OH
285 N NEt QIb a bond H a bond NH 0 NH Q3c OH
286 N NEt QIb a bond H ,a bond NH 0 a bond Q3a OH
287 N NEt QIb a bond H a bond NH 0 a bond Q3b OH 288 N NEt QIb a bond H a bond NH 0 a bond Q3c OH
289 N NEt QIc a bond Me a bond NH S NH Q3a OH
290 N NEt QIc a bond Me a bond NH S NH Q3b OH
291 N NEt QIc a bond Me a bond NH S NH Q3c OH 292 N NEt QIc a bond Me a bond NH S a bond Q3a OH 293 N NEt QIc a bond Me a bond NH S a bond Q3b OH
294 N NEt QIc a bond Me a bond NH S a bond Q3c OH 295 N NEt QIc a bond Me a bond NH 0 NH Q3a OH
296 N NEt QIc a bond Me a bond NH 0 NH Q3b OH
297 N NEt QIc a bond Me a bond NH 0 NH Q3c OH
298 N NEt QIc a bond Me a bond NH 0 a bond Q3a OH 299 N NEt QIc a bond Me a bond NH 0 a bond Q3b OH
300 N NEt QIc a bond Me a bond NH 0 a bond Q3c OH
301 N NEt QIc a bond H a bond NH S NH Q3a OH
302 N NEt QIc a bond H a bond NH S NH Q3b OH
303 N NEt QIc a bond H a bond NH S NH Q3c OH 304 N NEt QIc a bond H a bond NH S a bond Q3a OH
305 N NEt QIc a bond H a bond NH S a bond Q3b OH
306 N NEt QIc a bond H a bond NH S a bond Q3c OH
307 N NEt QIc a bond H a bond NH 0 NH Q3a OH
308 N NEt QIc a bond H a bond NH 0 NH Q3b OH 309 N NEt QIc a bond H a bond NH 0 NH Q3c OH
310 N NEt QIc a bond H a bond NH 0 a bond Q3a OH
311 N NEt QIc a bond H a bond NH 0 a bond Q3b OH
312 N NEt QIc a bond H a bond NH 0 a bond Q3c OH
313 N NEt QId a bond Me a bond NH S NH Q3a OH 314 N NEt QId a bond Me a bond NH S NH Q3b OH
315 N NEt QId a bond Me a bond NH S NH Q3c OH
316 N NEt QId a bond Me a bond NH S a bond Q3a OH
317 N NEt QId a bond Me a bond NH S a bond Q3b OH
318 N NEt QId a bond Me a bond NH S a bond Q3c OH 319 N NEt QId a bond Me a bond NH 0 NH Q3a OH
320 N NEt QId a bond Me a bond NH 0 NH Q3b OH
321 N NEt QId a bond Me a bond NH 0 NH Q3c OH
322 N NEt QId a bond Me. a bond NH 0 a bond Q3a OH
323 N NEt QId a bond Me a bond NH 0 a bond Q3b OH 324 N NEt QId a bond Me a bond NH 0 a bond Q3c OH
325 N NEt QId a bond H a bond NH S NH Q3a OH
326 N NEt QId a bond H a bond NH S NH Q3b OH
327 N NEt QId a bond H a bond NH S NH Q3c OH
328 N NEt QId a bond H a bond NH S a bond Q3a OH 329 N NEt QId a bond H a bond NH S a bond Q3b OH
330 N NEt QId a bond H a bond NH S a bond Q3c OH 331 N NEt QId a bond H a bond NH 0 NH Q3a OH
332 N NEt QId a bond H a bond NH 0 NH Q3b OH
333 N NEt QId a bond H a bond NH 0 NH Q3c OH
334 N NEt QId a bond H a bond NH 0 a bond Q3a OH 335 N NEt QId a bond H a bond' NH 0 a bond Q3b OH
336 N NEt QId a bond H a bond NH 0 a bond Q3c OH
337 N NEt QIe a bond Me a bond NH S NH Q3a OH
338 N NEt QIe a bond Me a bond NH S NH Q3b OH
339 N NEt QIe a bond Me a bond NH S NH Q3c OH 340 N NEt QIe a bond Me a bond NH S a bond Q3a OH
341 N NEt QIe a bond Me a bond NH S a bond Q3b OH
342 N NEt QIe a bond Me a bond NH S a bond Q3c OH
343 N NEt QIe a bond Me a bond NH 0 NH Q3a OH
344 N NEt QIe a bond Me a bond NH 0 NH Q3b OH 345 N NEt QIe a bond Me a bond NH 0 NH Q3c OH
346 N NEt QIe a bond Me a bond NH 0 a bond Q3a OH
347 N NEt QIe a bond Me a bond NH 0 a bond Q3b OH
348 N NEt QIe a bond Me a bond NH 0 a bond Q3c OH
349 N NEt QIe a bond H a bond NH S NH Q3a OH 350 N NEt QIe a bond H a bond NH S NH Q3b OH
351 N NEt QIe a bond H a bond NH S NH Q3c OH
352 N NEt QIe a bond H a bond NH S a bond Q3a OH
353 N NEt QIe a bond H a bond NH S a bond Q3b OH
354 N NEt QIe a bond H a bond NH S a bond Q3c OH 355 N NEt QIe a bond H a bond NH 0 NH Q3a OH
356 N NEt QIe a bond H a bond NH 0 NH Q3b OH
357 N NEt QIe a bond H a bond NH 0 NH Q3c OH
358 N NEt QIe a bond H a bond NH 0 a bond Q3a OH
359 N NEt QIe a bond H a bond NH 0 a bond Q3b OH 360 N NEt QIe a bond H a bond NH 0 a bond Q3c OH
361 N NEt QIf a bond Me a bond NH S NH Q3a OH
362 N NEt QIf a bond Me a bond NH S NH Q3b OH
363 N NEt QIf a bond Me a bond NH S NH Q3c OH
364 N NEt QIf a bond Me a bond NH S a bond Q3a OH 365 N NEt QIf a bond Me a bond NH S a bond Q3b OH
366 N NEt QIf a bond Me a bond NH S a bond Q3c OH 367 N NEt QIf a bond Me a bond NH 0 NH Q3a OH
368 N NEt QIf a bond Me a bond NH 0 NH Q3b OH
369 N NEt QIf a bond Me a bond NH 0 NH Q3c OH
370 N NEt QIf a bond Me a bond NH 0 a bond Q3a OH 371 N NEt QIf a bond Me a bond' NH 0 a bond Q3b OH
372 N NEt QIf a bond Me a bond NH 0 a bond Q3c OH
373 N NEt QIf a bond H a bond NH S NH Q3a OH
374 N NEt QIf a bond H a bond NH S NH Q3b OH
375 N NEt QIf a bond H a bond NH S NH Q3c OH 376 N NEt QIf a bond H a bond NH S a bond Q3a OH
377 N NEt QIf a bond H a bond NH S a bond Q3b OH
378 N NEt QIf a bond H a bond NH S a bond Q3c OH
379 N NEt QIf a bond H a bond NH 0 NH Q3a OH
380 N NEt QIf a bond H a bond NH 0 NH Q3b OH 381 N NEt QIf a bond H a bond NH 0 NH Q3c OH
382 N NEt QIf a bond H a bond NH 0 a bond Q3a OH
383 N NEt QIf a bond H a bond NH 0 a bond Q3b OH
384 N NEt QIf a bond H a bond NH 0 a bond Q3c OH
385 N NEt QIg a bond Me a bond NH S NH Q3a OH 386 N NEt QIg a bond Me a bond NH S NH Q3b OH
387 N NEt QIg a bond Me a bond NH S NH Q3c OH
388 N NEt QIg a bond Me a bond NH S a bond Q3a OH
389 N NEt QIg a bond Me a bond NH S a bond Q3b OH
390 N NEt QIg a bond Me a bond NH S a bond Q3c OH 391 N NEt QIg a bond Me a bond NH 0 NH Q3a OH
392 N NEt QIg a bond Me a bond NH 0 NH Q3b OH
393 N NEt QIg a bond Me a bond NH 0 NH Q3c OH
394 N NEt QIg a bond Me a bond NH 0 a bond Q3a OH
395 N NEt QIg a bond Me a bond NH 0 a bond Q3b OH 396 N NEt QIg a bond Me a bond NH 0 a bond Q3c OH
397 N NEt QIg a bond H a bond NH S NH Q3a OH
398 N NEt QIg a bond H a bond NH S NH Q3b OH
399 N NEt QIg a bond H a bond NH S NH Q3c OH
400 N NEt QIg a bond H a bond NH S a bond Q3a OH 401 N NEt QIg a bond H a bond NH S a bond Q3b OH
402 N NEt QIg a bond H a bond NH S a bond Q3c OH 403 N NEt QIg a bond H a bond NH 0 NH Q3a OH
404 N NEt QIg a bond H a bond NH 0 NH Q3b OH
405 N NEt QIg a bond H a bond NH 0 NH Q3c OH
406 N NEt Qig a bond H a bond NH 0 a bond Q3a OH
407 N NEt QIg a bond H a bond NH 0 a bond Q3b OH
408 N NEt Qig a bond H a bond NH 0 a bond Q3c OH
409 N NEt QIh a bond Me a bond NH S NH Q3a OH
410 N NEt QIh a bond Me a bond NH S NH Q3b OH
411 N NEt QIh a bond Me a bond NH S NH Q3c OH
412 N NEt QIh a bond Me a bond NH S a bond Q3a . OH
413 N NEt QIh a bond Me a bond NH S a bond Q3b OH
414 N NEt QIh a bond Me a bond NH S a bone 1 Q3c OH
415 N NEt QIh a bond Me a bond NH 0 NH Q3a OH
416 N NEt QIh a bond Me a bond NH 0 NH Q3b OH
417 N NEt QIh a bond Me a bond NH 0 NH Q3c OH
418 N NEt QIh a bond Me a bond NH 0 a bone 1 Q3a OH
419 N NEt QIh a bond Me a bond NH 0 a bond Q3b OH
420 N NEt QIh a bond Me a bond NH 0 a bone 1 Q3c OH
421 N NEt QIh a' bond H a bond NH S NH Q3a OH
422 N NEt QIh a bond H a bond NH S NH Q3b OH
423 N NEt QIh a bond H a bond NH S NH Q3c OH
424 N NEt QIh a bond H a bond NH S a bond Q3a OH
425 N NEt QIh a bond H a bond NH S a bond Q3b OH
426 N NEt QIh a bond H a bond NH S a bond Q3c OH
427 N NEt QIh a bond H a bond NH 0 NH Q3a OH
428 N NEt QIh a bond H a bond NH 0 NH Q3b OH
429 N NEt QIh a bond H a bond NH 0 NH Q3c OH
430 N NEt QIh a bond H .a bond NH 0 a bond Q3a OH
431 N NEt QIh a bond H a bond NH 0 a bond Q3b OH
432 N NEt QIh a bond H a bond NH 0 a bond Q3c OH
433 N NEt QIi a bond Me a bond NH S NH Q3a OH
434 N NEt QIi a bond Me a bond NH S NH Q3b OH
435 N NEt QIi a bond Me a bond NH S NH Q3c OH
436 N NEt QIi a bond Me a bond NH S a bone 1 Q3a OH
437 N NEt QIi a bond Me a bond NH S a bone 1 Q3b OH
438 N NEt QIi a bond Me a bond NH S a bone 1 Q3c OH 439 N NEt QIi a bond Me a bond NH 0 NH Q3a OH
440 N NEt QIi a bond Me a bond NH 0 NH Q3b OH
441 N NEt QIi a bond Me a bond NH 0 NH Q3c OH
442 N NEt QIi a bond Me a bond NH 0 a bond Q3a OH 443 N NEt QIi a bond Me a bond NH 0 a bond Q3b OH
444 N NEt QIi a bond Me a bond NH 0 a bond Q3c OH
445 N NEt QIi a bond H a bond NH S NH Q3a OH
446 N NEt QIi a bond H a bond NH S NH Q3b OH
447 N NEt QIi a bond H a bond NH S NH Q3c OH 448 N NEt QIi a bond H a bond NH S a bond Q3a OH
449 N NEt QIi a bond H a bond NH S a bond Q3b OH
450 N NEt QIi a bond H a bond NH S a bond Q3c OH
451 N NEt QIi a bond H a bond NH 0 NH Q3a OH
452 N NEt QIi a bond H a bond NH 0 NH Q3b OH 453 N NEt QIi a bond H a bond NH 0 NH Q3c OH
454 N NEt QIi a bond H a bond NH 0 a bond Q3a OH
455 N NEt QIi a bond H a bond NH 0 a bond Q3b OH
456 N NEt QIi a bond H a bond NH 0 a bond Q3c OH
457 N NEt QIj a bond Me a bond NH S NH Q3a OH 458 N NEt QIj a bond Me a bond NH S NH Q3b OH
459 N NEt QIj a bond Me a bond NH S NH Q3c OH
460 N NEt QIj a bond Me a bond NH S a bond Q3a OH
461 N NEt QIj a bond Me a bond NH S a bond Q3b OH
462 N NEt QIj a bond Me a bond NH S a bond Q3c OH 463 N NEt QIj a bond Me a bond NH 0 NH Q3a OH
464 N NEt QIj a bond Me a bond NH 0 NH Q3b OH
465 N NEt QIj a bond Me a bond NH 0 NH Q3c OH
466 N NEt QIj a bond Me a bond NH 0 a bond Q3a OH
467 N NEt QIj a bond Me a bond NH 0 a bond Q3b OH 468 N NEt QIj a bond Me a bond NH 0 a bond Q3c OH
469 N NEt QIj a bond H a bond NH S NH Q3a OH
470 N NEt QIj a bond H a bond NH S NH Q3b OH
471 N NEt QIj a bond H a bond NH S NH Q3c OH
472 N NEt QIj a bond H a bond NH S a bond Q3a OH 473 N NEt QIj a bond H a bond NH S a bond Q3b OH
474 N NEt QIj a bond H a bond NH S a bond Q3c OH 475 N NEt QIj a bond H a bond NH 0 NH Q3a OH
476 N NEt QIj a bond H a bond NH 0 NH Q3b OH
477 N NEt QIj a bond H a bond NH 0 NH Q3c OH
478 N NEt QIj a bond H a bond NH 0 a bond Q3a OH
479 N NEt QIj a bond H a bond NH 0 a bond Q3b OH
480 N NEt QIj a bond H a bond NH 0 a bond Q3c OH
481 N S QIa a bond Me a bond NH S NH Q3a OH
482 N S QIa a bond Me a bond NH S NH Q3b OH
483 N S QIa a bond Me a bond NH S NH Q3c OH
484 N S QIa a bond Me a bond NH S a bond Q3a OH
485 N S QIa a bond Me a bond NH S a bond Q3b OH
486 N S QIa a bond Me a bond NH S a bond Q3c OH
487 N S QIa a bond Me a bond NH 0 NH Q3a OH
488 N S QIa a bond Me a bond NH 0 NH Q3b OH
489 N S QIa a bond Me a bond NH 0 NH Q3c OH
490 N S QIa a bond Me a bond NH 0 a bond Q3a OH
491 N S QIa a bond Me a bond NH 0 a bond Q3b OH
492 N S QIa a bond Me a bond NH 0 a bond Q3c OH
493 N S QIa a bond H a bond NH S NH Q3a OH
494 N S QIa a bond H a bond NH S NH Q3b OH
495 N S QIa a bond H a bond NH S NH Q3c OH
496 N S QIa a bond H a bond NH S a bond Q3a OH
497 N S QIa a bond H a bond NH S a bond Q3b OH
498 N S QIa a bond H a bond NH S a bond Q3c OH
499 N S QIa a bond H a bond NH 0 NH Q3a OH
500 N S QIa a bond H a bond NH 0 NH Q3b OH
501 N S QIa a bond H a bond NH 0 NH Q3c OH
502 N S QIa a bond H a bond NH 0 a bond Q3a OH
503 N S QIa a bond H a bond NH 0 a bond Q3b OH
504 N S QIa a bond H a bond NH 0 a bond Q3c OH
505 N S QIb a bond Me a bond NH S NH Q3a OH
506 N S QIb a bond Me a bond NH S NH Q3b OH
507 N S QIb a bond Me a bond NH S NH Q3c OH
508 N S QIb a bond Me a bond NH S a bond Q3a OH
509 N S QIb a bond Me a bond NH S a bond Q3b OH
510 N S QIb a bond Me a bond NH S a bond Q3c OH 25J
511 N S QIb a bond Me a bond NH 0 NH Q3a OH
512 N S QIb a bond Me a bond NH 0 NH Q3b OH
513 N S QIb a bond Me a bond NH 0 NH Q3c OH
514 N S QIb a bond Me a bond NH 0 a bond Q3a OH
515 N S QIb a bond Me a bond NH 0 a bond Q3b OH
516 N S QIb a bond Me a bond NH 0 a bond Q3c OH
517 N S QIb a bond H a bond NH S NH Q3a OH
518 N S QIb a bond H a bond NH S NH Q3b OH
519 N S QIb a bond H a bond NH S NH Q3c OH
520 N S QIb a bond H a bond NH S a bond Q3a OH
521 N S QIb a bond H a bond NH S a bond Q3b OH
522 N S QIb a bond H a bond NH S a bond Q3c OH
523 N S QIb a bond H a bond NH 0 NH Q3a OH
524 N S QIb a bond H a bond NH 0 NH Q3b OH
525 N S QIb a bond H a bond NH 0 NH Q3c OH
526 N S QIb a bond H a bond NH 0 a bond Q3a OH
527 N S QIb a bond H a bond NH 0 a bond Q3b OH
528 N S QIb a bond H a bond NH 0 a bond Q3c OH
529 N S QIc a bond Me a bond NH S NH Q3a OH
530 N S QIc a bond Me a bond NH S NH Q3b OH
531 N S QIc a bond Me a bond NH S NH Q3c OH
532 N S QIc a bond Me a bond NH S a bond Q3a OH
533 N S QIc a bond Me a bond NH S a bond Q3b OH
534 N S QIc a bond Me a bond NH S a bond Q3c OH
535 N S QIc a bond Me a bond NH 0 NH Q3a OH
536 N S QIc a bond Me a bond NH 0 -NH Q3b OH
537 N S QIc a bond Me a bond NH 0 NH Q3c OH
538 N S QIc a bond Me a bond NH 0 a bond Q3a OH
539 N S QIc a bond Me a bond NH 0 a bond Q3b OH
540 N S QIc a bond Me a bond NH 0 a bond Q3c OH
541 N S QIc a bond H a bond NH S NH Q3a OH
542 N S QIc a bond H a bond NH S NH Q3b OH
543 N S QIc a bond H a bond NH S NH Q3c OH
544 N S QIc a bond H a bond NH S a bond Q3a OH
545 N S QIc a bond H a bond NH S a bond Q3b OH
546 N S QIc a bond H a bond NH S a bond Q3c OH 547 N S QIc a bond H a bond NH 0 NH Q3a OH
548 N S QIc a bond H a bond NH 0 NH Q3b OH
549 N S QIc a bond H a bond NH 0 NH Q3c OH
550 N S QIc a bond H a bond NH 0 a bond Q3a OH
551 N S QIc a bond H a bond NH 0 a bond Q3b OH
552 N S QIc a bond H a bond NH 0 a bond Q3c OH
553 N S QId a bond Me a bond NH S NH Q3a OH
554 N S QId a bond Me a bond NH S NH Q3b OH
555 N S QId a bond Me a bond NH S NH Q3c OH
556 N S QId a bond Me a bond NH S a bond Q3a . OH
557 N S QId a bond Me a bond NH S a bond Q3b OH
558 N S QId a bond Me a bond NH S a bond Q3c OH
559 N S QId a bond Me a bond NH 0 NH Q3a OH
560 N S QId a bond Me a bond NH 0 NH Q3b OH
561 N S QId a bond Me a bond NH 0 NH Q3c OH
562 N S QId a bond Me a bond NH 0 a bond Q3a . OH
563 N S QId a bond Me a bond NH 0 a bond Q3b OH
564 N S QId a bond Me a bond NH 0 a bond Q3c OH
565 N S QId a bond H a bond NH S NH Q3a OH
566 N S QId a bond H a bond NH S NH Q3b OH
567 N S QId a bond H a bond NH S NH Q3c OH
568 N S QId a bond H a bond NH S a bond Q3a OH
569 N S QId a bond H a bond NH S a bond Q3b OH
570 N S QId a bond H a bond NH S a bond Q3c OH
571 N S QId a bond H a bond NH 0 NH Q3a OH
572 N S QId a bond H a bond NH 0 NH Q3b OH
573 N S QId a bond H a bond NH 0 NH Q3c OH
574 N S QId a bond H a bond NH 0 a bond Q3a OH
575 N S QId a bond H a bond NH 0 a bond Q3b OH
576 N S QId a bond H a bond NH 0 a bond Q3c OH
577 N S QIe a bond Me a bond NH S NH Q3a OH
578 N S QIe a bond Me a bond NH S NH Q3b OH
579 N S QIe a bond Me a bond NH S NH Q3c OH
580 N S QIe a bond Me a bond NH S a bond Q3a OH
581 N S QIe a bond Me a bond NH S a bond Q3b OH
582 N S QIe a bond Me a bond NH S a bond Q3c OH 583 N S QIe a bond Me a bond NH 0 NH Q3a OH
584 N S QIe a bond Me a bond NH 0 NH Q3b OH
585 N S QIe a bond Me a bond NH 0 NH Q3c OH
586 N S QIe a bond Me a bond NH 0 a bond Q3a OH 587 N S QIe a bond Me a bond' NH 0 a bond Q3b OH
588 N S QIe a bond Me a bond NH 0 a bond Q3c OH
589 N S QIe a bond H a bond NH S NH Q3a OH
590 N S QIe a bond H a bond NH S NH Q3b OH
591 N S QIe a bond H a bond NH S NH Q3c OH 592 N S QIe a bond H a bond NH S a bond Q3a OH
593 N S QIe a bond H a bond NH S a bond Q3b OH
594 N S QIe a bond H a bond NH S a bond Q3c OH
595 N S QIe a bond H a bond NH 0 NH Q3a OH
596 N S QIe a bond H a bond NH 0 NH Q3b OH 597 N S QIe a bond H a bond NH 0 NH Q3c OH
598 N S QIe a bond H a bond NH 0 a bond Q3a OH
599 N S QIe a bond H a bond NH 0 a bond Q3b OH
600 N S QIe a bond H a bond NH 0 a bond Q3c OH
601 N S QIf a bond Me a bond NH S NH Q3a OH 602 N S QIf a bond Me a bond NH S NH Q3b OH
603 N S QIf a bond Me a bond NH S NH Q3c OH
604 N S QIf a bond Me a bond NH S a bond Q3a OH
605 N S QIf a bond Me a bond NH S a bond Q3b OH
606 N S QIf a bond Me a bond NH S a bond Q3c OH 607 N S QIf a bond Me a bond NH 0 NH Q3a OH
608 N S QIf a bond Me a bond NH 0 NH Q3b OH
609 N S QIf a bond Me a bond NH 0 NH Q3c OH
610 N S QIf a bond Me a bond NH 0 a bond Q3a OH
611 N S QIf a bond Me a bond NH 0 a bond Q3b OH 612 N S QIf a bond Me a bond NH 0 a bond Q3c OH
613 N S QIf a bond H a bond NH S NH Q3a OH
614 N S QIf a bond H a bond NH S NH Q3b OH
615 N S QIf a bond H a bond NH S NH Q3c OH
616 N S QIf a bond H a bond NH S a bond Q3a OH 617 N S QIf a bond H a bond NH S a bond Q3b OH
618 N S QIf a bond H a bond NH S a bond Q3c OH 619 N S QIf a bond H a bond NH 0 NH Q3a OH
620 N S QIf a bond H a bond NH 0 NH Q3b OH
621 N S QIf a bond H a bond NH 0 NH Q3c OH
622 N S QIf a bond H a bond NH 0 a bond Q3a OH 623 N . S QIf a bond H a bond ' NH 0 a bond Q3b OH
624 N S QIf a bond H a bond NH 0 a bond Q3c OH
625 N S QIg a bond Me a bond NH S NH Q3a OH
626 N S QIg a bond Me a bond NH S NH Q3b OH
627 N S QIg a bond Me a bond NH S NH Q3c OH 628 N S QIg a bond Me a bond NH S a bond Q3a OH
629 N S QIg a bond Me a bond NH S a bond Q3b OH
630 N S QIg a bond Me a bond NH S a bond Q3c OH
631 N S QIg a bond Me a bond NH 0 NH Q3a OH
632 N S QIg a bond Me a bond NH 0 NH Q3b OH 633 N S QIg a bond Me a bond NH 0 NH Q3c OH
634 N S QIg a bond Me a bond NH 0 a bond Q3a OH
635 N S QIg a bond Me a bond NH 0 a bond Q3b OH
636 N S QIg a bond Me a bond NH a bond Q3c OH
637 N S QIg a bond H a bond NH NH Q3a OH 638 N S QIg a bond H a bond NH S NH Q3b OH
639 N S QIg a bond H a bond NH S NH Q3c OH
640 N S QIg a bond H a bond NH S a bond Q3a OH
641 N S QIg a bond H a bond NH S a bond Q3b OH
642 N S QIg a bond H a bond NH S a bond Q3c OH 643 N S QIg a bond H a bond NH 0 NH Q3a OH
644 N S QIg a bond H a bond NH 0 NH Q3b OH
645 N S QIg a bond H a bond NH 0 NH Q3c OH
646 N S QIg a bond H .a bond NH 0 a bond Q3a OH
647 N S QIg a bond H a bond NH 0 a bond Q3b OH 648 N S QIg a bond H a bond NH 0 a bond Q3c OH
649 N S QIh a bond Me a bond NH S NH Q3a OH
650 N S QIh a bond Me a bond NH S NH Q3b OH
651 N S QIh a bond Me a bond NH S NH Q3c OH
652 N S QIh a bond Me a bond NH S a bond Q3a OH 653 N S QIh a bond Me a bond NH S a bond Q3b OH
654 N S QIh a bond Me a bond NH S a bond Q3c OH 655 N S QIh a bond Me a bond NH 0 NH Q3a OH
656 N S QIh a bond Me a bond NH 0 NH Q3b OH
657 N S QIh a bond Me a bond NH 0 NH Q3c OH
658 N S QIh a bond Me a bond NH 0 a bond Q3a OH 659 N S QIh a bond Me a bond NH 0 a bond Q3b OH
660 N S QIh a bond Me a bond NH 0 a bond Q3c OH
661 N S QIh a bond H a bond NH S NH Q3a OH
662 N S QIh a bond H a bond NH S NH Q3b OH
663 N S QIh a bond H a bond NH S NH Q3c OH 664 N S QIh a bond H a bond NH S a bond Q3a OH
665 N S QIh a bond H a bond NH S a bond Q3b OH
666 N S QIh a bond H a bond NH S a bond Q3c OH
667 N S QIh a bond H a bond NH 0 NH Q3a OH
668 N S QIh a bond H a bond NH 0 NH Q3b OH 669 N S QIh a bond H a bond NH 0 NH Q3c OH
670 N S QIh a bond H a bond NH 0 a bond Q3a OH
671 N S QIh a bond H a bond NH 0 a bond Q3b OH
672 N S QIh a bond H a bond NH 0 a bond Q3c OH
673 N S QIi a bond Me a bond NH S NH Q3a OH 674 N S QIi a bond Me a bond NH S NH Q3b OH
675 N S QIi a bond Me a bond NH S NH Q3c OH
676 N S QIi a bond Me a bond NH S a bond Q3a OH
677 N S QIi a bond Me a bond NH S a bond Q3b OH
678 N S QIi a bond Me a bond NH S a bond Q3c OH 679 N S QIi a bond Me a bond NH 0 NH Q3a OH
680 N S QIi a bond Me a bond NH 0 NH Q3b OH
681 N S QIi a bond Me a bond NH 0 NH Q3c OH
682 N S QIi a bond Me a bond NH 0 a bond Q3a OH
683 N S QIi a bond Me a bond NH 0 a bond Q3b OH 684 N S QIi a bond Me a bond NH 0 a bond Q3c OH
685 N S QIi a bond H a bond NH S NH Q3a OH
686 N S QIi a bond H a bond NH S NH Q3b OH
687 N S QIi a bond H a bond NH S NH Q3c OH
688 N S QIi a bond H a bond NH S a bond Q3a OH 689 N S QIi a bond H a bond NH S a bond Q3b OH
690 N S QIi a bond H a bond NH S a bond Q3c OH 691 N S QIi a bond H a bond NH 0 NH Q3a OH
692 N S QIi a bond H a bond NH 0 NH Q3b OH
693 N S QIi a bond H a bond NH 0 NH Q3c OH
694 N S QIi a bond H a bond NH 0 a bond Q3a OH
695 N S QIi a bond H a bond 'NH 0 a bond Q3b OH
696 N S QIi a bond H a bond NH 0 a bond Q3c OH
697 N S QIj a bond Me a bond NH S NH Q3a OH
698 N S QIj a bond Me a bond NH S NH Q3b OH
699 N S QIj a bond Me a bond NH S NH Q3c OH
700 N S QIj a bond Me a bond NH S a bond . Q3a OH
701 N S QIj a bond Me a bond NH S a bond . Q3b OH
702 N S QIj a bond Me a bond NH S a bond . Q3c OH
703 N S QIj a bond Me a bond NH 0 NH Q3a OH
704 N S Qij a bond Me a bond NH 0 NH Q3b OH
705 N S QIj a bond Me a bond NH 0 NH Q3c OH
706 N S Qij a bond Me a bond NH 0 a bond . Q3a OH
707 N S Qij a bond Me a bond NH 0 a bond . Q3b OH
708 N S Qij a bond Me a bond NH 0 a bond . Q3c OH
709 N S Qij a bond H a bond NH S NH Q3a OH
710 N S Qij a bond H a bond NH S NH Q3b OH
711 N S Qij a bond H a bond NH S NH Q3c OH
712 N S Qij a bond H a bond NH S a bond Q3a OH
713 N S Qij a bond H a bond NH S a bond Q3b OH
714 N S Qij a bond., H a bond NH S a bond Q3c OH
715 N S Qij a bond H a bond NH 0 NH Q3a OH
716 N S Qij a bond H a bond NH 0 NH Q3b OH
717 N S Qij a bond H a bond NH 0 NH Q3c OH
718 N S Qij a bond H a bond NH 0 a bond Q3a OH
719 N S Qij a bond H a bond NH 0 a bond Q3b OH
720 N S Qij a bond H a bond NH 0 a bond Q3c OH
721 N 0 QIa a bond Me a bond NH S NH Q3a OH
722 N 0 QIa a bond Me a bond NH S NH Q3b OH
723 N 0 QIa a bond Me a bond NH S NH Q3c OH
724 N 0 QIa a bond Me a bond NH S a bond Q3a OH
725 N 0 QIa a bond Me a bond NH S a bond Q3b OH
726 N 0 QIa a bond Me a bond NH S a bond Q3c OH 727 N 0 QIa a bond Me a bond NH 0 NH Q3a OH
728 N 0 QIa a bond Me a bond NH 0 NH Q3b OH
729 N 0 QIa a bond Me a bond NH 0 NH Q3c OH
730 N 0 QIa a bond Me a bond NH 0 a bond Q3a OH 731 N 0 QIa a bond Me a bond' NH 0 a bond Q3b OH
732 N 0 QIa a bond Me a bond NH 0 a bond Q3c OH
733 N 0 QIa a bond H a bond NH S NH Q3a OH
734 N 0 QIa a bond H a bond NH S NH Q3b OH
735 N 0 QIa a bond H a bond NH S NH Q3c OH 736 N 0 QIa a bond H a bond NH S a bond Q3a OH
737 N 0 QIa a bond H a bond NH S a bond Q3b OH
738 N 0 QIa a bond H a bond NH S a bond Q3c OH
739 N 0 QIa a bond H a bond NH 0 NH Q3a OH
740 N 0 QIa a bond H a bond NH 0 NH Q3b OH 741 N 0 QIa a bond H a bond NH 0 NH Q3c OH
742 N 0 QIa a bond H a bond NH 0 a bond Q3a OH
743 N 0 QIa a bond H a bond NH 0 a bond Q3b OH
744 N 0 QIa a bond H a bond NH 0 a bond Q3c OH
745 N 0 QIb a bond Me a bond NH S NH Q3a OH 746 N 0 QIb a bond Me a bond NH S NH Q3b OH
747 N 0 QIb a bond Me a bond NH S NH Q3c OH
748 N 0 QIb a bond Me a bond NH S a bond Q3a OH
749 N 0 QIb a bond Me a bond NH S a bond Q3b OH
750 N 0 QIb a bond Me a bond NH S a bond Q3c OH 751 N 0 QIb a bond Me a bond NH 0 NH Q3a OH
752 N 0 QIb a bond Me a bond NH 0 NH " Q3b OH
753 N 0 QIb a bond Me a bond NH 0 NH Q3c OH
754 N 0 QIb a bond Me . a bond NH 0 a bond Q3a OH
755 N 0 QIb a bond Me a bond NH 0 a bond Q3b OH 756 N 0 QIb a bond Me a bond NH 0 a bond Q3c OH
757 N 0 QIb a bond H a bond NH S NH Q3a OH
758 N 0 QIb a bond H a bond NH S NH Q3b OH
759 N 0 QIb a bond H a bond NH S NH Q3c OH
760 N 0 QIb a bond H a bond NH S a bond Q3a OH 761 N 0 QIb a bond H a bond NH S a bond Q3b OH
762 N 0 QIb a bond H a bond NH S a bond Q3c OH 763 N 0 QIb a bond H a bond NH 0 NH Q3a OH
764 N 0 QIb a bond H a bond NH 0 NH Q3b OH
765 N 0 QIb a bond H a bond NH 0 NH Q3c OH
766 N 0 QIb a bond H a bond NH 0 a bond Q3a OH 767 N 0 QIb a bond H a bond 'NH 0 a bond Q3b OH
768 N 0 QIb a bond H a bond NH 0 a bond Q3c OH
769 N 0 QIc a bond Me a bond NH S NH Q3a OH
770 N 0 QIc a bond Me a bond NH S NH Q3b OH
771 N 0 QIc a bond Me a bond NH S NH Q3c OH 772 N 0 QIc a bond Me a bond NH S a bond Q3a OH
773 N 0 QIc a bond Me a bond NH S a bond Q3b OH
774 N 0 QIc a bond Me a bond NH S a bond Q3c OH
775 N 0 QIc a bond Me a bond NH 0 NH Q3a OH
776 N 0 QIc a bond Me a bond NH 0 NH Q3b OH 777 N 0 QIc a bond Me a bond NH 0 NH Q3c OH
778 N 0 QIc a bond Me a bond NH 0 a bond Q3a OH
779 N 0 QIc a bond Me a bond NH 0 a bond Q3b OH
780 N 0 QIc a bond Me a bond NH 0 a bond Q3c OH
781 N 0 QIc a bond H a bond NH S NH Q3a OH 782 N 0 QIc a bond H a bond NH S NH Q3b OH
783 N 0 QIc a bond H a bond NH S NH Q3c OH
784 N 0 QIc a bond H a bond NH S a bond Q3a OH
785 N 0 QIc a bond H a bond NH S a bond Q3b OH
786 N 0 QIc a bond H a bond NH S a bond Q3c OH 787 N 0 QIc a bond H a bond NH 0 NH Q3a OH
788 N 0 QIc a bond H a bond NH 0 NH Q3b OH
789 N 0 QIc a bond H a bond NH 0 NH Q3c OH
790 N 0 QIc a bond H a bond NH 0 a bond Q3a OH
791 N 0 QIc a bond H a bond NH 0 a bond Q3b OH 792 N 0 QIc a bond H a bond NH 0 a bond Q3c OH
793 N 0 QId a bond Me a bond NH S NH Q3a OH
794 N 0 QId a bond Me a bond NH S NH Q3b OH
795 N 0 QId a bond Me a bond NH S NH Q3c OH
796 N 0 QId a bond Me a bond NH S a bond Q3a OH 797 N 0 QId a bond Me a bond NH S a bond Q3b OH
798 N 0 QId a bond Me a bond NH S a bond Q3c OH 799 N 0 QId a bond Me a bond NH 0 NH Q3a OH
800 N 0 QId a bond Me a bond NH 0 NH Q3b OH
801 N 0 QId a bond Me a bond NH 0 NH Q3c OH
802 N 0 QId a bond Me a bond NH 0 a bond Q3a OH
803 N 0 QId a bond Me a bond NH 0 a bond Q3b OH
804 N 0 QId a bond Me a bond NH 0 a bond Q3c OH
805 N 0 QId a bond H a bond NH S NH Q3a OH
806 N 0 QId a bond H a bond NH S NH Q3b OH
807 N 0 QId a bond H a bond NH S NH Q3c OH
808 N 0 QId a bond H a bond NH S a bond Q3a OH
809 N 0 QId a bond H a bond NH S a bond Q3b OH
810 N 0 QId a bond H a bond NH S a bond Q3c OH
811 N 0 QId a bond H a bond NH 0 NH Q3a OH
812 N 0 QId a bond H a bond NH 0 NH Q3b OH
813 N 0 QId a bond H a bond NH 0 NH Q3c OH
814 N 0 QId a bond H a bond NH 0 a bond Q3a OH
815 N 0 QId a bond H a bond NH 0 a bond Q3b OH
816 N 0 QId a bond H a bond NH 0 a bond Q3c OH
817 N 0 QIe a' bond Me a bond NH S NH Q3a OH
818 N 0 QIe a bond Me a bond NH S NH Q3b OH
819 N 0 QIe a bond Me a bond NH S NH Q3c OH
820 N 0 QIe a bond Me a bond NH S a bond Q3a OH
821 N 0 QIe a bond Me a bond NH S a bond Q3b OH
822 N 0 QIe a bond Me a bond NH S a bond Q3c OH
823 N 0 QIe a bond Me a bond NH 0 NH Q3a OH
824 N 0 QIe a bond Me a bond NH 0 NH Q3b OH
825 N 0 QIe a bond Me a bond NH 0 NH Q3c OH
826 N 0 QIe a bond Me a bond NH 0 a bond Q3a OH
827 N 0 QIe a bond Me a bond NH 0 a bond Q3b OH
828 N 0 QIe a bond Me a bond NH 0 a bond Q3c OH
829 N 0 QIe a bond H a bond NH S NH Q3a OH
830 N 0 QIe a bond H a bond NH S NH Q3b OH
831 N 0 QIe a bond H a bond NH S NH Q3c OH
832 N 0 QIe a bond H a bond NH S a bond Q3a OH
833 N 0 QIe a bond H a bond NH S a bond Q3b OH
834 N 0 QIe a bond H a bond NH S a bond Q3c OH 835 N 0 QIe a bond H a bond NH 0 NH Q3a OH
836 N 0 QIe a bond H a bond NH 0 NH Q3b OH
837 N 0 QIe a bond H a bond NH 0 NH Q3c OH
838 N 0 QIe a bond H a bond NH 0 a bond Q3a OH 839 N 0 QIe a bond H a bond "NH 0 a bond Q3b OH
840 N 0 QIe a bond H a bond NH 0 a bond Q3c OH
841 N 0 QIf a bond Me a bond NH S NH Q3a OH
842 N 0 QIf a bond Me a bond NH S NH Q3b OH
843 N 0 QIf a bond Me a bond NH S NH Q3c OH 844 N 0 QIf a bond Me a bond NH S a bond Q3a OH
845 N 0 QIf a bond Me a bond NH S a bond Q3b OH
846 N 0 QIf a bond Me a bond NH S a bond Q3c OH
847 N 0 QIf a bond Me a bond NH 0 NH Q3a OH
848 N 0 QIf a bond Me a bond NH 0 NH Q3b OH 849 N 0 QIf a bond Me a bond NH 0 NH Q3c OH
850 N 0 QIf a bond Me a bond NH 0 a bond Q3a OH
851 N 0 QIf a bond Me a bond NH 0 a bond Q3b OH
852 N 0 QIf a bond Me a bond NH 0 a bond Q3c OH
853 N 0 QIf a bond H a bond NH S H Q3a OH 854 N 0 QIf a bond H a bond NH S H Q3b OH
855 N 0 QIf a bond H a bond NH S H Q3c OH
856 N 0 QIf a bond H a bond NH S a bond Q3a OH
857 N 0 QIf a bond H a bond NH S a bond Q3b OH
858 N 0 QIf a bond H a bond NH S a bond Q3c OH 859 N 0 QIf a bond H a bond NH 0 NH Q3a OH
860 N 0 QIf a bond H a bond NH 0 NH Q3b OH
861 N 0 QIf a bond H a bond NH 0 NH Q3c OH
862 N 0 QIf a bond H a bond NH 0 a bond Q3a OH
863 N 0 QIf a bond H a bond NH 0 a bond Q3b OH 864 N 0 QIf a bond H a bond NH 0 a bond Q3c OH
865 N 0 QIg a bond Me a bond NH S NH Q3a OH
866 N 0 QIg a bond Me a bond NH S NH Q3b OH
867 N 0 QIg a bond Me a bond NH S NH Q3c OH
868 N 0 QIg a bond Me a bond NH S a bond Q3a OH 869 N 0 QIg a bond Me a bond NH S a bond Q3b OH
870 N 0 QIg a bond Me a bond NH S a bond Q3c OH 871 N 0 QIg a bond Me a bond NH 0 NH Q3a OH
872 N 0 QIg a bond Me a bond NH 0 NH Q3b OH
873 N 0 QIg a bond Me a bond NH 0 NH Q3c OH
874 N 0 QIg a bond Me a bond NH 0 a bond Q3a OH
875 N 0 QIg a bond Me a bond NH 0 a bond Q3b OH
876 N 0 QIg a bond Me a bond NH 0 a bond Q3c OH
877 N 0 QIg a bond H a bond NH S NH Q3a OH
878 N 0 QIg a bond H a bond NH S NH Q3b OH
879 N 0 QIg a bond H a bond NH S NH Q3c OH
880 N 0 QIg a bond H a bond NH S a bond Q3a OH
881 N 0 QIg a bond H a bond NH S a bond Q3b OH
882 N 0 QIg a bond H a bond NH S a bond Q3c OH
883 N 0 QIg a bond H a bond NH 0 NH Q3a OH
884 N 0 QIg a bond H a bond NH 0 NH Q3b OH
885 N 0 QIg a bond H a bond NH 0 NH Q3c OH
886 N 0 QIg a bond H a bond NH 0 a bond Q3a OH
887 N 0 QIg a bond H a bond NH 0 a bond Q3b OH
888 N 0 QIg a bond H a bond NH 0 a bond Q3c OH
889 N 0 QIh a bond Me a bond NH S NH Q3a OH
890 N 0 QIh a bond Me a bond NH S NH Q3b OH
891 N 0 QIh a bond Me a bond NH S NH Q3c OH
892 N 0 QIh a bond Me a bond NH S a bond Q3a OH
893 N 0 QIh a bond Me a bond NH S a bond Q3b OH
894 N 0 QIh a bond Me a bond NH S a bond Q3c OH
895 N 0 QIh a bond Me a bond NH 0 NH Q3a OH
896 N 0 QIh a bond Me a bond NH 0 NH Q3b OH
897 N 0 QIh a bond Me a bond NH 0 NH Q3c OH
898 N 0 QIh a bond Me . a bond NH 0 a bond Q3a OH
899 N 0 QIh a bond Me a bond NH 0 a bond Q3b OH
900 N 0 QIh a bond Me a bond NH 0 a bond Q3c OH
901 N 0 QIh a bond H a bond NH S NH Q3a OH
902 N 0 QIh a bond H a bond NH S NH Q3b OH
903 'N 0 QIh a bond H a bond NH S NH Q3c OH
904 N 0 QIh a bond H a bond NH S a bond Q3a OH
905 N 0 QIh a bond H a bond NH S a bond Q3b OH
906 N 0 QIh a bond H a bond NH S a bond Q3c OH 907 N 0 QIh a bond H a bond NH 0 Im Q3a OH
908 N 0 QIh a bond H a bond NH 0 Im Q3b OH
909 N 0 QIh a bond H a bond NH 0 Im Q3c OH
910 N 0 QIh a bond H a bond NH 0 a bond Q3a OH
911 N 0 QIh a bond H a bond NH 0 a bond Q3b OH
912 N 0 QIh a bond H a bond NH 0 a bond Q3c OH
913 N 0 QIi a bond Me a bond NH S N NHH Q Q33aa O OHH
914 N 0 QIi a bond Me a bond NH S N NHH Q Q33bb O OHH
915 N 0 QIi a bond Me a bond NH S N NHH Q Q33cc O OHH
916 N 0 QIi a bond Me a bond NH S aa bboonndd 1 QQ33aa . OOHH
917 N 0 QIi a bond Me a bond NH S a bond : Q3b OH
918 N 0 QIi a bond Me a bond NH S a bond . Q3c OH
919 N 0 QIi a bond Me a bond NH 0 NH Q3a OH
920 N 0 QIi a bond Me a bond NH 0 NH Q3b OH
921 N 0 QIi a bond Me a bond NH 0 NH Q3c OH
922 N 0 QIi a bond Me a bond NH 0 a bond . Q3a . OH
923 N 0 QIi a bond Me a bond NH 0 a bond . Q3b OH
924 N 0 QIi a bond Me a bond NH 0 a bond . Q3c OH
925 N 0 QIi a bond H a bond NH S I Q3a OH
926 N 0 QIi a bond H a bond NH S I Q3b OH
927 N 0 QIi a bond H a bond NH S I Q3c OH
928 N 0 QIi a bond H a bond NH S a bond Q3a OH
929 N 0 QIi a bond H a bond NH S a bond Q3b OH
930 N 0 QIi a bond H a bond NH S a bond Q3c OH
931 N 0 QIi a bond H a bond NH 0 I Q3a OH
932 N 0 QIi a bond H a bond NH 0 I Q3b OH
933 N 0 QIi a bond H a bond NH 0 I Q3c OH
934 N 0 QIi a bond H a bond NH 0 a bond Q3a OH
935 N 0 QIi a bond H a bond NH 0 a bond Q3b OH
936 N 0 QIi a bond H a bond NH 0 a bond Q3c OH
937 N 0 QIj a bond Me a bond NH S NH Q3a OH
938 N 0 Qij a bond Me a bond NH S NH Q3b OH
939 N 0 QIj a bond Me a bond NH S NH Q3c OH
940 N 0 QIj a bond Me a bond NH S a bond Q3a OH
941 N 0 Qij a bond Me a bond NH S a bond Q3b OH
942 N 0 Qij a bond Me a bond NH S a bond Q3c OH 943 N 0 QIj a bond Me a bond NH 0 NH Q3a OH
944 N 0 QIj a bond Me a bond NI I 0 NH Q3b OH
945 N 0 QIj a bond Me a bond NIϊ 0 NH Q3c OH
946 N 0 Qij a bond Me a bond NH 0 a bond Q3a OH
947 N 0 Qij a bond Me a bond NI 1 0 a bond Q3b OH
948 N 0 Qij a bond Me a bond NH 0 a bond Q3c OH
949 N 0 Qij a bond H a bond NH S NH Q3a OH
950 N 0 Qij a bond H a bond NH S NH Q3b OH
951 N 0 Qij a bond H a bond NH S NH Q3c OH
952 N 0 Qij a bond H a bond NH S a bond Q3a OH
953 N 0 Qij a bond H a bond NH S a bond Q3b OH
954 N 0 Qij a bond H a bond NH S a bond Q3c OH
955 N 0 Qij a bond H a bond NH 0 NH Q3a OH
956 N 0 Qij a bond H a bond NH 0 NH Q3b OH
957 N 0 Qij a bond H a bond NH 0 NH Q3c OH
958 N 0 Qij a bond H a bond NH 0 a bond Q3a OH
959 N 0 Qij a bond H a bond NH 0 a bond Q3b OH
960 N 0 Qij a bond H a bond NH 0 a bond Q3c OH
961 CH Me QIa a bond Me a bond NH S NH Q3a OH
962 CH NMe QIa a bond Me a bond NH S NH Q3b OH
963 CH NMe QIa a bond Me a bond NH S NH Q3c OH
964 CH NMe QIa a bond Me a bond NH S a bond Q3a OH
965 CH NMe QIa a bond Me a bond NH S a bond Q3b OH
966 CH NMe QIa a bond Me a bond NH S a bond Q3c OH
967 CH NMe QIa a bond Me a bond NH 0 NH Q3a OH
968 CH NMe QIa a bond Me a bond NH 0 NH Q3b OH
969 CH NMe QIa a bond Me a bond NH 0 NH Q3c OH
970 CH NMe QIa a bond Me a bond NH 0 a bond Q3a OH
971 CH NMe QIa a bond Me a bond NH 0 a bond Q3b OH
972 CH NMe QIa a bond Me a bond NH 0 a bond Q3c OH
973 CH NMe QIa a bond H a bond NH S NH Q3a OH
974 CH NMe QIa a bond H a bond NH S NH Q3b OH
975 CH NMe QIa a bond H a bond NH S NH Q3c OH
976 CH NMe QIa a bond H a bond } 01 S a bond Q3a OH
977 CH NMe QIa a bond H a bond F S a bond Q3b OH
978 CH NMe QIa a bond H a bond NH S a bond Q3c OH 979 CH NMe QIa a bond H a bond NH 0 NH Q3a OH
980 CH NMe QIa a bond H a bond NH 0 NH Q3b OH
981 CH NMe QIa a bond H a bond NH 0 NH Q3c OH
982 CH NMe QIa a bond H a bond NH 0 a bond Q3a OH 983 CH NMe QIa a bond H a bond NH 0 a bond Q3b OH
984 CH NMe QIa a bond H a bond NH 0 a bond Q3c OH
985 CH NMe QIb a bond Me a bond NH S NH Q3a OH
986 CH NMe QIb a bond Me a bond NH S NH Q3b OH
987 CH NMe QIb a bond Me a bond NH S NH Q3c OH 988 CH NMe QIb a bond Me a bond NH S a bond Q3a OH
989 CH NMe QIb a bond Me a bond NH S a bond Q3b OH
990 CH NMe QIb a bond Me a bond NH S a bond Q3c OH
991 CH NMe QIb a bond Me a bond NH 0 NH Q3a OH
992 CH NMe QIb a bond Me a bond NH 0 NH Q3b OH 993 CH NMe QIb a bond Me a bond NH 0 NH Q3c OH
994 CH NMe QIb a bond Me a bond NH 0 a bond Q3a OH
995 CH NMe QIb a bond Me a bond NH 0 a bond Q3b OH
996 CH NMe QIb a bond Me a bond NH 0 a bond Q3c OH
997 CH NMe QIb a bond H a bond NH S NH Q3a OH 998 CH NMe QIb a bond H a bond NH S NH Q3b OH
999 CH NMe QIb a bond H a bond NH S NH Q3c OH
1000 CH NMe QIb a bond H a bond NH S a bond Q3a OH
1001 CH NMe QIb a bond H a bond NH S a bond Q3b OH
1002 CH NMe QIb a bond H a bond NH S a bond Q3c OH 1003 CH NMe QIb a bond H a bond NH 0 NH Q3a OH
1004 CH NMe QIb a bond H a bond NH 0 NH Q3b OH
1005 CH NMe QIb a bond H a bond NH 0 NH Q3c OH
1006 CH NMe QIb a bond H a bond NH 0 a bond Q3a OH
1007 CH NMe QIb a bond H a bond NH 0 a bond Q3b OH 1008 CH NMe QIb a bond H a bond NH 0 a bond Q3c OH
1009 CH NMe QIc a bond Me a bond NH S NH Q3a OH
1010 CH NMe QIc a bond Me a bond NH S NH Q3b OH
1011 CH NMe QIc a bond Me a bond NH S NH Q3c OH
1012 CH NMe QIc a bond Me a bond NH S a bond Q3a OH 1013 CH NMe QIc a bond Me a bond NH S a bond Q3b OH
1014 CH NMe QIc a bond Me a bond NH S a bond Q3c OH 1015 CH NMe QIc a bond Me a bond NH 0 NH Q3a OH
1016 CH NMe QIc a bond Me a bond NH 0 NH Q3b OH
1017 CH NMe QIc a bond Me a bond NH 0 NH Q3c OH
1018 CH NMe QIc a bond Me a bond NH 0 a bond Q3a . OH
1019 CH NMe QIc a bond Me a bond NH 0 a bond Q3b OH
1020 CH NMe QIc a bond Me a bond NH 0 a bond Q3c OH
1021 CH NMe QIc a bond H a bond NH S NH Q3a OH
1022 CH NMe QIc a bond H a bond NH S NH Q3b OH
1023 CH NMe QIc a bond H a bond NH S NH Q3c OH
1024 CH NMe QIc a bond H a bond NH S a bond Q3a OH
1025 CH NMe QIc a bond H a bond NH S a bond Q3b OH
1026 CH NMe QIc a bond H a bond NH S a bond Q3c OH
1027 CH NMe QIc a bond H a bond NH 0 NH Q3a OH
1028 CH NMe QIc a bond H a bond NH 0 NH Q3b OH
1029 CH NMe QIc a bond H a bond NH 0 NH Q3c OH
1030 CH NMe QIc a bond H a bond NH 0 a bond Q3a OH
1031 CH NMe QIc a bond H a bond NH 0 a bond Q3b OH
1032 CH NMe QIc a bond H a bboonndd N NHH 0 0 aa bboonndd Q Q33cc O OHH
1033 CH NMe QId a bond Me a bboonndd N NHH S S N NHH Q Q33aa O OHH
1034 CH NMe QId a bond Me a bboonndd N NHH S S N NHH Q Q33bb O OHH
1035 CH NMe QId a bond Me a bboonndd N NHH S S N NHH Q Q33cc O OHH
1036 CH NMe QId a bond Me a bond NH S a bond Q3a OH
1037 CH NMe QId a bond Me a bond NH S a bond Q3b OH
1038 CH NMe QId a bond Me a bond NH S a bond Q3c OH
1039 CH NMe QId a bond Me a bond NH 0 NH Q3a OH
1040 CH NMe QId a bond Me a bond NH 0 NH Q3b OH
1041 CH NMe QId a bond Me a bond NH 0 NH Q3c OH
1042 CH NMe QId a bond Me . a bond NH 0 a bond Q3a OH
1 1004433 C CHH NMMfee QQIIdd a bond Me a bond NH 0 a bond Q3b OH
1 1004444 C CHH NNMlfee QQIIdd a bond Me a bond NH 0 a bond Q3c . OH
1 1004455 C CHH NNMlfee QQIIdd a bond H a bond NH S NH Q3a OH
1 1004466 C CHH NMMfee QQIIdd a bond H a bond NH S NH Q3b OH
1 1004477 C CHH NmMfee QQIIdd a bond H a bond NH S NH Q3c OH
1048 CH NMe QId a bond H a bond NH S a bond Q3a OH
1049 CH NMe QId a bond H a bond NH S a bond Q3b OH
1050 CH NMe QId a bond H a bond NH S a bond Q3c OH 1051 CH NMe QId a bond H a bond NH 0 NH Q3a OH
1052 CH NMe QId a bond H a bond NH 0 NH Q3b OH
1053 CH NMe QId a bond H a bond NH 0 NH Q3c OH
1054 CH NMe QId a bond H a bond NH 0 a bond Q3a OH 1055 CH NMe QId a bond H a bond ' NH 0 a bond Q3b OH
1056 CH NMe QId a bond H a bond NH 0 a bond Q3c OH
1057 CH NMe QIe a bond Me a bond NH S NH Q3a OH
1058 CH NMe QIe a bond Me a bond NH S NH Q3b OH
1059 CH NMe QIe a bond Me a bond NH S NH Q3c OH 1060 CH NMe QIe a bond Me a bond NH S a bond Q3a OH
1061 CH NMe QIe a bond Me a bond NH S a bond Q3b OH
1062 CH NMe QIe a bond Me a bond NH S a bond Q3c OH
1063 CH NMe QIe a bond Me a bond NH 0 NH Q3a OH
1064 CH NMe QIe a bond Me a bond NH 0 NH Q3b OH 1065 CH NMe QIe a bond Me a bond NH 0 NH Q3c OH
1066 CH NMe QIe a bond Me a bond NH 0 a bond Q3a OH
1067 CH NMe QIe a bond Me a bond NH 0 a bond Q3b OH
1068 CH NMe QIe a bond Me a bond NH 0 a bond Q3c OH
1069 CH NMe QIe a" bond H a bond NH S NH Q3a OH 1070 CH NMe QIe a bond H a bond NH S NH Q3b OH
1071 CH NMe QIe a bond H a bond NH S NH Q3c OH
1072 CH NMe QIe a bond H a bond NH S a bond Q3a OH
1073 CH NMe QIe a bond H a bond NH S a bond Q3b OH
1074 CH NMe QIe a bond H a bond NH S a bond Q3c OH 1075 CH NMe QIe a bond H a bond NH 0 NH Q3a OH
1076 CH NMe QIe a bond H a bond NH 0 NH Q3b OH
1077 CH NMe QIe a bond H a bond NH 0 NH Q3c OH
1078 CH NMe QIe a bond H .a bond NH 0 a bond Q3a OH
1079 CH NMe QIe a bond H a bond NH 0 a bond Q3b OH 1080 CH NMe QIe a bond H a bond NH 0 a bond Q3c OH
1081 CH NMe QIf a bond Me a bond NH S NH Q3a OH
1082 CH NMe QIf a bond Me a bond NH S NH Q3b OH
1083 CH NMe QIf a bond Me a bond NH S NH Q3c OH
1084 CH NMe QIf a bond Me a bond NH S a bond Q3a OH 1085 CH NMe QIf a bond Me a bond NH S a bond Q3b OH
1086 CH NMe QIf a bond Me a bond NH S a bond Q3c OH 1087 CH NMe QIf a bond Me a bond NH 0 NH Q3a OH
1088 CH NMe QIf a bond Me a bond NH 0 NH Q3b OH
1089 CH NMe QIf a bond Me a bond NH 0 NH Q3c OH
1090 CH NMe QIf a bond Me a bond NH 0 a bond Q3a OH 1091 CH NMe QIf a bond Me a bond NH 0 a bond Q3b OH
1092 CH NMe QIf a bond Me a bond NH 0 a bond Q3c OH
1093 CH NMe QIf a bond H a bond NH S NH Q3a OH
1094 CH NMe QIf a bond H a bond NH S NH Q3b OH
1095 CH NMe QIf a bond H a bond NH S NH Q3c OH 1096 CH NMe QIf a bond H a bond NH S a bond Q3a OH
1097 CH NMe QIf a bond H a bond NH S a bond Q3b OH
1098 CH NMe QIf a bond H a bond NH S a bond Q3c OH
1099 CH NMe QIf a bond H a bond NH 0 NH Q3a OH
1100 CH NMe QIf a bond H a bond NH 0 NH Q3b OH 1101 CH NMe QIf a bond H a bond NH 0 NH Q3c OH
1102 CH NMe QIf a bond H a bond NH 0 a bond Q3a OH
1103 CH NMe QIf a bond H a bond NH 0 a bond Q3b OH
1104 CH NMe QIf a bond H a bond NH 0 a bond Q3c OH
1105 CH NMe QIg a bond Me a bond NH S NH Q3a OH 1106 CH NMe QIg a bond Me a bond NH S NH Q3b OH
1107 CH NMe QIg a bond Me a bond NH S NH Q3c OH
1108 CH NMe QIg a bond Me a bond NH S a bond Q3a OH
1109 CH NMe QIg a bond Me a bond NH S a bond Q3b OH
1110 CH NMe QIg a bond Me a bond NH S a bond Q3c OH 1111 CH NMe QIg a bond Me a bond NH 0 NH Q3a OH
1112 CH NMe QIg a bond Me a bond NH 0 NH Q3b OH
1113 CH NMe QIg a bond Me a bond NH 0 NH Q3c OH
1114 CH NMe QIg a bond Me a bond NH 0 a bond Q3a OH
1115 CH NMe QIg a bond Me a bond NH 0 a bond Q3b OH 1116 CH NMe QIg a bond Me a bond NH 0 a bond Q3c OH
1117 CH NMe QIg a bond H a bond NH S NH Q3a OH
1118 CH NMe QIg a bond H a bond NH S NH Q3b OH
1119 CH NMe QIg a bond H a bond NH S NH Q3c OH
1120 CH NMe QIg a bond H a bond NH S a bond Q3a OH 1121 CH NMe QIg a bond H a bond NH S a bond Q3b OH
1122 CH NMe QIg a bond H a bond NH S a bond Q3c OH 1123 CH NMe QIg a bond H a bond NH 0 NH Q3a OH
1124 CH NMe QIg a bond H a bond NH 0 NH Q3b OH
1125 CH NMe QIg a bond H a bond NH 0 NH Q3c OH
1126 CH NMe QIg a bond H a bond NH 0 a bond Q3a OH 1127 CH NMe QIg a bond H a bond NH 0 a bond Q3b OH
1128 CH NMe QIg a bond H a bond NH 0 a bond Q3c OH
1129 CH NMe QIh a bond Me a bond NH S NH Q3a OH
1130 CH NMe QIh a bond Me a bond NH S NH Q3b OH
1131 CH NMe QIh a bond Me a bond NH S NH Q3c OH 1132 CH NMe QIh a bond Me a bond NH S a bond Q3a OH
1133 CH NMe QIh a bond Me a bond NH S a bond Q3b OH
1134 CH NMe QIh a bond Me a bond NH S a bond Q3c OH
1135 CH NMe QIh a bond Me a bond NH 0 NH Q3a OH
1136 CH NMe QIh a bond Me a bond NH 0 NH Q3b OH 1137 CH NMe QIh a bond Me a bond NH 0 NH Q3c OH
1138 CH NMe QIh a bond Me a bond NH 0 a bond Q3a OH
1139 CH NMe QIh a bond Me a bond NH 0 a bond Q3b OH
1140 CH NMe QIh a bond Me a bond NH 0 a ■ bond Q3c OH
1141 CH NMe QIh a bond H a bond NH S NH Q3a OH 1142 CH NMe QIh a bond H a bond NH S NH Q3b OH
1143 CH NMe QIh a bond H a bond NH S NH Q3c OH
1144 CH NMe QIh a bond H a bond NH S a bond Q3a OH
1145 CH NMe QIh a bond H a bond NH S a bond Q3b OH
1146 CH NMe QIh a bond H a bond NH S a bond Q3c OH 1147 CH NMe QIh a bond H a bond NH 0 NH Q3a OH
1148 CH NMe QIh a bond H a bond NH 0 NH Q3b OH
1149 CH NMe QIh a bond H a bond NH 0 NH Q3c OH
1150 CH NMe QIh a bond H a bond NH 0 a bond Q3a OH
1151 CH NMe QIh a bond H a bond NH 0 a bond Q3b OH 1152 CH NMe QIh a bond H a bond NH 0 a bond Q3c OH
1153 CH NMe QIi a bond Me a bond NH S NH Q3a OH
1154 CH NMe QIi a bond Me a bond NH S NH Q3b OH
1155 CH NMe QIi a bond Me a bond NH S NH Q3c OH
1156 CH NMe QIi a bond Me a bond NH S a bond Q3a OH 1157 CH NMe QIi a bond Me a bond NH S a bond Q3b OH
1158 CH NMe QIi a bond Me a bond NH S a bond Q3c OH 1159 CH NMe QIi a bond Me a bond NH 0 NH Q3a OH
1160 CH NMe QIi a bond Me a bond NH 0 NH Q3b OH
1161 CH NMe QIi a bond Me a bond NH 0 NH Q3c OH
1162 CH NMe QIi a bond Me a bond NH 0 a bond Q3a OH 1163 CH NMe QIi a bond Me a bond NH 0 a bond Q3b OH
1164 CH NMe QIi a bond Me a bond NH 0 a bond Q3c OH
1165 CH NMe QIi a bond H a bond NH S NH Q3a OH
1166 CH NMe QIi a bond H a bond NH S NH Q3b OH
1167 CH NMe QIi a bond H a bond NH S NH Q3c OH 1168 CH NMe QIi a bond H a bond NH S a bond Q3a OH
1169 CH NMe QIi a bond H a bond NH S a bond Q3b OH
1170 CH NMe QIi a bond H a bond NH S a bond Q3c OH
1171 CH NMe QIi a bond H a bond NH 0 NH Q3a OH
1172 CH NMe QIi a bond H a bond NH 0 NH Q3b OH 1173 CH NMe QIi a bond H a bond NH 0 NH Q3c OH
1174 CH NMe QIi a bond H a bond NH 0 a bond Q3a OH
1175 CH NMe QIi a bond H a bond NH 0 a bond Q3b OH
1176 CH NMe QIi a bond H a bond NH 0 a bond Q3c OH
1177 CH NMe QIj a bond Me a bond NH S NH Q3a OH 1178 CH NMe QIj a bond Me a bond NH S NH Q3b OH
1179 CH NMe QIj a bond Me a bond NH S NH Q3c OH
1180 CH NMe QIj a bond Me a bond NH S a bond Q3a OH
1181 CH NMe QIj a bond Me a bond NH S a bond Q3b OH
1182 CH NMe QIj a bond Me a bond NH S a bond Q3c OH 1183 CH NMe QIj a bond Me a bond NH 0 NH Q3a OH
1184 CH NMe QIj a bond Me a bond NH 0 NH Q3b OH
1185 CH NMe QIj a bond Me a bond NH 0 NH Q3c OH
1186 CH NMe QIj a bond Me. a bond NH 0 a bond Q3a OH
1187 CH NMe QIj a bond Me a bond NH 0 a bond Q3b OH 1188 CH NMe QIj a bond Me a bond NH 0 a bond Q3c OH
1189 CH NMe QIj a bond H a bond NH S NH Q3a OH
1190 CH NMe QIj a bond H a bond NH S NH Q3b OH 1191' CH NMe QIj a bond H a bond NH S NH Q3c OH 1192 CH NMe QIj a bond H a bond NH S a bond Q3a OH 1193 CH NMe QIj a bond H a bond NH S a bond Q3b OH
1194 CH NMe QIj a bond H a bond NH S a bond Q3c OH 1195 CH NMe QIj a bond H a bond I O I 03a OH
1196 CH NMe QIj a bond H a bond NH 0 NH Q3b OH
1197 CH NMe QIj a bond H a bond NH 0 NH Q3c OH
1198 CH NMe QIj a bond H a bond NH 0 a bond Q3a OH 1199 CH NMe QIj a bond H a bond NH 0 a bond Q3b OH
1200 CH NMe QIj a bond H a bond NH 0 a bond Q3c OH
1201 CH NEt QIa a bond Me a bond NH S NH Q3a OH
1202 CH NEt QIa a bond Me a bond NH S NH Q3b OH
1203 CH NEt QIa a bond Me a bond NH. S NH Q3c OH 1204 CH NEt QIa a bond Me a bond NH S a bond Q3a OH
1205 CH NEt QIa a bond Me a bond NH S a bond Q3b OH
1206 CH NEt QIa a bond Me a bond NH S a bond Q3c OH
1207 CH NEt QIa a bond Me a bond NH 0 NH Q3a OH
1208 CH NEt QIa a bond Me a bond NH 0 NH Q3b OH 1209 CH NEt QIa a bond Me a bond NH 0 NH Q3c OH
1210 CH NEt QIa a bond Me a bond NH 0 a bond Q3a OH
1211 CH NEt QIa a bond Me a bond NH 0 a bond Q3b OH
1212 CH NEt QIa a bond Me a bond NH 0 a bond Q3c OH
1213 CH NEt QIa a bond H a bond NH S NH Q3a OH 1214 CH NEt QIa a bond H a bond NH S NH Q3b OH
1215 CH NEt QIa a bond H a bond NH S NH Q3c OH
1216 CH NEt QIa a bond H a bond NH S a bond Q3a OH
1217 CH NEt QIa a bond H a bond NH S a bond Q3b OH
1218 CH NEt QIa a bond H a bond NH S a bond Q3c OH 1219 CH NEt QIa a bond H a bond NH 0 NH Q3a OH
1220 CH NEt QIa a bond H a bond NH 0 NH Q3b OH
1221 CH NEt QIa a bond H a bond NH 0 NH Q3c OH
1222 CH NEt QIa a bond H .a bond NH 0 a bond Q3a OH
1223 CH NEt QIa a bond H a bond NH 0 a bond Q3b OH 1224 CH NEt QIa a bond H a bond NH 0 a bond Q3c OH
1225 CH NEt QIb a bond Me a bond NH S NH Q3a OH
1226 CH NEt QIb a bond Me a bond NH S NH Q3b OH 1227' CH NEt QIb a bond Me a bond NH S NH Q3c OH 1228 CH NEt QIb a bond Me a bond NH S a bond Q3a OH 1229 CH NEt QIb a bond Me a bond NH S a bond Q3b OH
1230 CH NEt QIb a bond Me a bond NH S a bond Q3c OH 1231 CH NEt QIb a bond Me a bboonndd NNHH 00 NNHH QQ33aa OOHH
1232 CH NEt QIb a bond Me a bboonndd N NHH 0 0 N NHH Q Q33bb O OHH
1233 CH NEt QIb a bond Me a bboonndd N NHH 0 0 N NHH Q Q33cc O OHH
1234 CH NEt QIb a bond Me a bond NH 0 a bond Q3a OH
1235 CH NEt QIb a bond Me a bond NH 0 a bond Q3b OH
1236 CH NEt QIb a bond Me a bond NH 0 a bond Q3c OH
1237 CH NEt QIb a bond H a bond NH S S Nϊ MH Q( 333aa O OHH
1238 CH NEt QIb a bond H a bond NH S S N I MH Q£ 333bb O OHH
1239 CH NEt QIb a bond H a bond NH S S N I MH Q£ 333cc O OHH
1240 CH NEt QIb a bond H a bond NH S a bond Q3a OH
1241 CH NEt QIb a bond H a bond NH S a bond Q3b OH
1242 CH NEt QIb a bond H a bond NH S a bond Q3c OH
1243 CH NEt QIb a bond H a bond NH 0 I M ( 33a OH
1244 CH NEt QIb a bond H a bond NH 0 ϊ M ( 33b OH
1245 CH NEt QIb a bond H a bond NH 0 I M ( 33c OH
1246 CH NEt QIb a bond H a bond NH 0 a bond Q3a OH
1247 CH NEt QIb a bond H a bond NH 0 a bond Q3b OH
1248 CH NEt QIb a bond H a bond NH 0 a bond Q3c OH
1249 CH NEt QIc a bond Me a bond NH S NH Q3a OH
1250 CH NEt QIc a bond Me a bond NH S NH Q3b OH
1251 CH NEt QIc a bond Me a bond NH S NH Q3c OH
1252 CH NEt QIc a bond Me a bond NH S a bond Q3a OH
1253 CH NEt QIc a bond Me a bond NH S a bond Q3b OH
1254 CH NEt QIc a bond Me a bond NH S a bond Q3c OH
1255 CH NEt QIc a bond Me a bond NH 0 NH Q3a OH
1256 CH NEt QIc a bond Me a bond NH 0 NH Q3b OH
1257 CH NEt QIc a bond Me a bond NH 0 NH Q3c OH
1258 CH NEt QIc a bond Me. a bond NH 0 a bond Q3a OH
1259 CH NEt QIc a bond Me a bond NH 0 a bond Q3b OH
1260 CH NEt QIc a bond Me a bond NH 0 a bond Q3c OH
1261 CH NEt QIc a bond H a bond NH S 1 N MH ( Q J33aa O OHH
1262 CH NEt QIc a bond H a bond NH S I N MH ( Q 333bb O OHH
1263' CH NEt QIc a bond H a bond NH S I N WH ( Q 333cc O OHH
1264 CH NEt QIc a bond H a bond NH S a bond Q3a OH
1265 CH NEt QIc a bond H a bond NH S a bond Q3b OH
1266 CH NEt QIc a bond H a bond NH S a bond Q3c OH 1267 CH NEt QIc a bond H a bond NH 0 NH Q3a OH
1268 CH NEt QIc a bond H a bond NH 0 NH Q3b OH
1269 CH NEt QIc a bond H a bond NH 0 NH Q3c OH
1270 CH NEt QIc a bond H a bond NH 0 a bond Q3a OH 1271 CH NEt QIc a bond H a bond NH 0 a bond Q3b OH
1272 CH NEt QIc a bond H a bond NH 0 a bond Q3c OH
1273 CH NEt QId a bond Me a bond NH S NH Q3a OH
1274 CH NEt QId a bond Me a bond NH S NH Q3b OH
1275 CH NEt QId a bond Me a bond NH S NH Q3c OH 1276 CH NEt QId a bond Me a bond NH S a bond Q3a OH
1277 CH NEt QId a bond Me a bond NH S a bond Q3b OH
1278 CH NEt QId a bond Me a bond NH S a bond Q3c OH
1279 CH NEt QId a bond Me a bond NH 0 NH Q3a OH
1280 CH NEt QId a bond Me a bond NH 0 NH Q3b OH 1281 CH NEt QId a bond Me a bond NH 0 NH Q3c OH
1282 CH NEt QId a bond Me a bond NH 0 a bond Q3a OH
1283 CH NEt QId a bond Me a bond NH 0 a bond Q3b OH
1284 CH NEt QId a bond Me a bond NH 0 a bond Q3c OH
1285 CH NEt QId a bond H a bond NH S NH Q3a OH 1286 CH NEt QId a bond H a bond NH S NH Q3b OH
1287 CH NEt QId a bond H a bond NH S NH Q3c OH
1288 CH NEt QId a bond H a bond NH S a bond Q3a OH
1289 CH NEt QId a bond H a bond NH S a bond Q3b OH
1290 CH NEt QId a bond H a bond NH S a bond Q3c OH 1291 CH NEt QId a bond H a bond NH 0 NH Q3a OH
1292 CH NEt QId a bond H a bond NH 0 NH Q3b OH
1293 CH NEt QId a bond H a bond NH 0 NH Q3c OH
1294 CH NEt QId a bond H a bond NH 0 a bond Q3a OH
1295 CH NEt QId a bond H a bond NH 0 a bond Q3b OH 1296 CH NEt QId a bond H a bond NH 0 a bond Q3c OH
1297 CH NEt QIe a bond Me a bond NH S NH Q3a OH
1298 CH NEt QIe a bond Me a bond NH S NH Q3b OH
1299 CH NEt QIe a bond Me a bond NH S NH Q3c OH
1300 CH NEt QIe a bond Me a bond NH S a bond Q3a OH 1301 CH NEt QIe a bond Me a bond NH S a bond Q3b OH
1302 CH NEt QIe a bond Me a bond NH S a bond Q3c OH 1303 CH NEt QIe a bond Me a bond NH 0 NH Q3a OH
1304 CH NEt QIe a bond Me a bond NH 0 NH Q3b OH
1305 CH NEt QIe a bond Me a bond NH 0 NH Q3c OH
1306 CH NEt QIe a bond Me a bond NH 0 a bond Q3a OH 1307 CH NEt QIe a bond Me a bond NH 0 a bond Q3b OH
1308 CH NEt QIe a bond Me a bond NH 0 a bond Q3c OH
1309 CH NEt QIe a bond H a bond NH S NH Q3a OH
1310 CH NEt QIe a bond H a bond NH S NH Q3b OH
1311 CH NEt QIe a bond H a bond NH S NH Q3c OH 1312 CH NEt QIe a bond H a bond NH S a bond Q3a OH
1313 CH NEt QIe a bond H a bond NH S a bond Q3b OH
1314 CH NEt QIe a bond H a bond NH S a bond Q3c OH
1315 CH NEt QIe a bond H a bond NH 0 NH Q3a OH
1316 CH NEt QIe a bond H a bond NH 0 NH Q3b OH 1317 CH NEt QIe a bond H a bond NH 0 NH Q3c OH
1318 CH NEt QIe a bond H a bond NH 0 a bond Q3a OH
1319 CH NEt QIe a bond H a bond NH 0 a bond Q3b OH
1320 CH NEt QIe a bond H a bond NH 0 a bond Q3c OH
1321 CH NEt QIf a bond Me a bond NH S NH Q3a OH 1322 CH NEt QIf a bond Me a bond NH S NH Q3b OH
1323 CH NEt QIf a bond Me a bond NH S NH Q3c OH
1324 CH NEt QIf a bond Me a bond NH S a bond Q3a OH
1325 CH NEt QIf a bond Me a bond NH S a bond Q3b OH
1326 CH NEt QIf a bond Me a bond NH S a bond Q3c OH 1327 CH NEt QIf a bond Me a bond NH 0 NH Q3a OH
1328 CH NEt QIf a bond Me a bond NH 0 NH Q3b OH
1329 CH NEt QIf a bond Me a bond NH 0 NH Q3c OH
1330 CH NEt QIf a bond Me a bond NH 0 a bond Q3a OH
1331 CH NEt QIf a bond Me a bond NH 0 a bond Q3b OH 1332 CH NEt QIf a bond Me a bond NH 0 a bond Q3c OH
1333 CH NEt QIf a bond H a bond NH S NH Q3a OH
1334 CH NEt QIf a bond H a bond NH S NH Q3b OH
1335 CH NEt QIf a bond H a bond NH S NH Q3c OH
1336 CH NEt QIf a bond H a bond NH S a bond Q3a OH 1337 CH NEt QIf a bond H a bond NH S a bond Q3b OH
1338 CH NEt QIf a bond H a bond NH S a bond Q3c OH 1339 CH NEt QIf a bond H a bond NH 0 NH Q3a OH
1340 CH NEt QIf a bond H a bond NH 0 NH Q3b OH
1341 CH NEt QIf a bond H a bond NH 0 NH Q3c OH
1342 CH NEt QIf a bond H a bond NH 0 a bond Q3a OH 1343 CH NEt QIf a bond H a bond NH 0 a bond Q3b OH
1344 CH NEt QIf a bond H a bond NH 0 a bond Q3c OH
1345 CH NEt QIg a bond Me a bond NH S NH Q3a OH
1346 CH NEt QIg a bond Me a bond NH S NH Q3b OH
1347 CH NEt QIg a bond Me a bond NH S NH Q3c OH 1348 CH NEt QIg a bond Me a bond NH S a bond Q3a OH
1349 CH NEt QIg a bond Me a bond NH S a bond Q3b OH
1350 CH NEt QIg a bond Me a bond NH S a bond Q3c OH
1351 CH NEt QIg a bond Me a bond NH 0 NH Q3a OH
1352 CH NEt QIg a bond Me a bond NH 0 NH Q3b OH 1353 CH NEt QIg a bond Me a bond NH 0 NH Q3c OH
1354 CH NEt QIg a bond Me a bond NH 0 a bond Q3a OH
1355 CH NEt QIg a bond Me a bond NH 0 a bond Q3b OH
1356 CH NEt QIg a bond Me a bond NH 0 a bond Q3c OH
1357 CH NEt QIg a bond H a bond NH S NH Q3a OH 1358 CH NEt QIg a bond H a bond NH S NH Q3b OH
1359 CH NEt QIg a bond H a bond NH S NH Q3c OH
1360 CH NEt QIg a bond H a bond NH S a bond Q3a OH
1361 CH NEt QIg a bond H a bond NH S a bond Q3b OH
1362 CH NEt QIg a bond H a bond NH S a bond Q3c OH 1363 CH NEt QIg a bond H a bond NH 0 NH Q3a OH
1364 CH NEt QIg a bond H a bond NH 0 NH Q3b OH
1365 CH NEt QIg a bond H a bond NH 0 NH Q3c OH
1366 CH NEt QIg a bond H a bond NH 0 a bond Q3a OH
1367 CH NEt QIg a bond H a bond NH 0 a bond Q3b OH 1368 CH NEt QIg a bond H a bond NH 0 a bond Q3c OH
1369 CH NEt QIh a bond Me a bond NH S NH Q3a OH
1370 CH NEt QIh a bond Me a bond NH S NH Q3b OH
1371 CH NEt QIh a bond Me a bond NH S NH Q3c OH
1372 CH NEt QIh a bond Me a bond NH S a bond Q3a OH 1 1337733 C CHH N NEEtt Q QIIhh aa bboonndd M Mee a bond NH S a bond Q3b OH
1374 CH NEt QIh a bond Me a bond NH S a bond Q3c OH 1375 CH NEt QIh a bond Me a bond NH 0 NH Q3a OH
1376 CH NEt QIh a bond Me a bond NH 0 NH Q3b OH
1377 CH NEt QIh a bond Me a bond NH 0 NH Q3c OH
1378 CH NEt QIh a bond Me a bond NH 0 a bond Q3a OH 1379 CH NEt QIh a bond Me a bond NH 0 a bond Q3b OH
1380 CH NEt QIh a bond Me a bond NH 0 a bond Q3c OH
1381 CH NEt QIh a bond H a bond NH S NH Q3a OH
1382 CH NEt QIh a bond H a bond NH S NH Q3b OH
1383 CH NEt QIh a bond H a bond NH S NH Q3c OH 1384 CH NEt QIh a bond H a bond NH S a bond Q3a OH
1385 CH NEt QIh a bond H a bond NH S a bond Q3b OH
1386 CH NEt QIh a bond H a bond NH S a bond Q3c OH
1387 CH NEt QIh a bond H a bond NH 0 NH Q3a OH
1388 CH NEt QIh a bond H a bond NH 0 NH Q3b OH 1389 CH NEt QIh a bond H a bond NH 0 NH Q3c OH
1390 CH NEt QIh a bond H a bond NH 0 a bond Q3a OH
1391 CH NEt QIh a bond H a bond NH 0 a bond Q3b OH
1392 CH NEt QIh a bond H a bond NH 0 a bond Q3c OH
1393 CH NEt QIi a" bond Me a bond NH S NH Q3a OH 1394 CH NEt QIi a bond Me a bond NH S NH Q3b OH
1395 CH NEt QIi a bond Me a bond NH S NH Q3c OH
1396 CH NEt QIi a bond Me a bond NH S a bond Q3a OH
1397 CH NEt QIi a bond Me a bond NH S a bond Q3b OH
1398 CH NEt QIi a bond Me a bond NH S a bond Q3c OH 1399 CH NEt QIi a bond Me a bond NH 0 NH Q3a OH
1400 CH NEt QIi a bond Me a bond NH 0 NH Q3b OH
1401 CH NEt QIi a bond Me a bond NH 0 NH Q3c OH
1402 CH NEt QIi a bond Me. a bond NH 0 a bond Q3a OH
1403 CH NEt QIi a bond Me a bond NH 0 a bond Q3b OH 1404 CH NEt QIi a bond Me a bond NH 0 a bond Q3c OH
1405 CH NEt QIi a bond H a bond NH S NH Q3a OH
1406 CH NEt QIi a bond H a bond NH S NH Q3b OH 1407' CH NEt QIi a bond H a bond NH S NH Q3c OH 1408 CH NEt QIi a bond H a bond NH S a bond Q3a OH 1409 CH NEt QIi a bond H a bond NH S a bond Q3b OH
1410 CH NEt QIi a bond H a bond NH S a bond Q3c OH 1411 CH NEt QIi a bond H a bond NH 0 NH Q3a OH
1412 CH NEt QIi a bond H a bond NH 0 NH Q3b OH
1413 CH NEt QIi a bond H a bond NH 0 NH Q3c OH
1414 CH NEt QIi a bond H a bond NH 0 a bond Q3a OH 1415 CH NEt QIi a bond H a bond NH 0 a bond Q3b OH
1416 CH NEt QIi a bond H a bond NH 0 a bond Q3c OH
1417 CH NEt QIj a bond Me a bond NH S NH Q3a OH
1418 CH NEt QIj a bond Me a bond NH S NH Q3b OH
1419 CH NEt QIj a bond Me a bond NH S NH Q3c OH 1420 CH NEt QIj a bond Me a bond NH S a bond Q3a OH
1421 CH NEt QIj a bond Me a bond NH S a bond Q3b OH
1422 CH NEt QIj a bond Me a bond NH S a bond Q3c OH
1423 CH NEt QIj a bond Me a bond NH 0 NH Q3a OH
1424 CH NEt QIj a bond Me a bond NH 0 NH Q3b OH 1425 CH NEt QIj a bond Me a bond NH 0 NH Q3c OH
1426 CH NEt QIj a bond Me a bond NH 0 a bond Q3a OH
1427 CH NEt QIj a bond Me a bond NH 0 a bond Q3b OH
1428 CH NEt QIj a bond Me a bond NH 0 a bond Q3c OH
1429 CH NEt QIj a' bond H a bond NH S NH Q3a OH 1430 CH NEt QIj a bond H a bond NH S NH Q3b OH
1431 CH NEt QIj a bond H a bond NH S NH Q3c OH
1432 CH NEt QIj a bond H a bond NH S a bond Q3a OH
1433 CH NEt QIj a bond H a bond NH S a bond Q3b OH
1434 CH NEt QIj a bond H a bond NH S a bond Q3c OH 1435 CH NEt QIj a bond H a bond NH 0 NH Q3a OH
1436 CH NEt QIj a bond H a bond NH 0 NH Q3b OH
1437 CH NEt QIj a bond H a bond NH 0 NH Q3c OH
1438 CH NEt QIj a bond H a bond NH 0 a bond Q3a OH
1439 CH NEt QIj a bond H a bond NH 0 a bond Q3b OH 1440 CH NEt QIj a bond H a bond NH 0 a bond Q3c OH
1441 CH S QIa a bond Me a bond NH S NH Q3a OH
1442 CH S QIa a bond Me a bond NH S NH Q3b OH
1443 CH S QIa a bond Me a bond NH S NH Q3c OH
1444 CH S QIa a bond Me a bond NH S a bond Q3a OH 1 1444455 C CHH S S Q QIIaa a bond Me a bond NH S a bond Q3b OH
1446 CH S Q QIIaa a bond Me a bond NH S a bond Q3c OH 1447 CH S QIa a bond Me a bond NH 0 NH Q3a OH
1448 CH S QIa a bond Me a bond NH 0 NH Q3b OH
1449 CH S QIa a bond Me a bond NH 0 NH Q3c OH
1450 CH S QIa a bond Me a bond NH 0 a bond Q3a OH
1451 CH S QIa a bond Me a bond NH 0 a bond Q3b OH
1452 CH S QIa a bond Me a bond NH 0 a bond Q3c OH
1453 CH S QIa a bond H a bond NH S NH Q3a OH
1454 CH S QIa a bond H a bond NH S NH Q3b OH
1455 CH S QIa a bond H a bond NH S NH Q3c OH
1456 CH S QIa a bond H a bond NH S a bond Q3a OH
1457 CH S QIa a bond H a bond NH S a bond Q3b OH
1458 CH S QIa a bond H a bond NH S a bond Q3c OH
1459 CH S QIa a bond H a bond NH 0 NH Q3a OH
1460 CH S QIa a bond H a bond NH 0 NH Q3b OH
1461 CH S QIa a bond H a bond NH 0 NH Q3c OH
1462 CH S QIa a bond H a bond NH 0 a bond Q3a OH
1463 CH S QIa a bond H a bond NH 0 a bond Q3b OH
1464 CH S QIa a bond H a bond NH 0 a bond Q3c OH
1465 CH S QIb a bond Me a bond NH S NH Q3a OH
1466 CH S QIb a bond Me a bond NH S NH Q3b OH
1467 CH S QIb a bond Me a bond NH S NH Q3c OH
1468 CH S QIb a bond Me a bond NH S a bond Q3a OH
1469 CH S QIb a bond Me a bond NH S a bond Q3b OH
1470 CH S QIb a bond Me a bond NH S a bond Q3c OH
1471 CH S QIb a bond Me a bond NH 0 NH Q3a OH
1472 CH S QIb a bond Me a bond NH 0 NH Q3b OH
1473 CH S QIb a bond Me a bond NH 0 NH Q3c OH
1474 CH S QIb a bond Me a bond NH 0 a bond Q3a OH
1475 CH S QIb a bond Me a bond NH 0 a bond Q3b OH
1476 CH S QIb a bond Me a bond NH 0 a bond Q3c OH
1477 CH S QIb a bond H a bond NH S NH Q3a i OH
1478 CH S QIb a bond H a bond NH S NH Q3b i OH
1479 CH S QIb a bond H a bond NH S NH Q3c i OH
1480 CH S QIb a bond H a bond NH S a bond Q3a OH
1481 CH S QIb a bond H a bond NH S a bond Q3b OH
1482 CH S QIb a bond H a bond NH S a bond Q3c OH 1483 CH S QIb a bond H a bond NH 0 NH Q3a OH
1484 CH S QIb a bond H a bond NH 0 NH Q3b OH
1485 CH S QIb a bond H a bond NH 0 NH Q3c OH
1486 CH S QIb a bond H a bond NH 0 a bond Q3a OH
1487 CH S QIb a bond H a bond NH 0 a bond Q3b OH
1488 CH S QIb a bond H a bond NH 0 a bond Q3c OH
1489 CH S QIc a bond Me a bond NH S N NHH Q Q33aa O OHH
1490 CH S QIc a bond Me a bond NH S N NHH Q Q33bb O OHH
1491 CH S QIc a bond Me a bond NH S N NHH Q Q33cc O OHH
1492 CH S QIc a bond Me a bond NH S a bboonndd . QQ33aa O OHH
1493 CH S QIc a bond Me a bond NH S a bond . Q3b OH
1494 CH S QIc a bond Me a bond NH S a bond . Q3c OH
1495 CH S QIc a bond Me a bond NH 0 NH Q3a OH
1496 CH S QIc a bond Me a bond NH 0 NH Q3b OH
1497 CH S QIc a bond Me a bond NH 0 NH Q3c OH
1498 CH S QIc a bond Me a bond NH 0 a bond . Q3a OH
1499 CH S QIc a bond Me a bond NH 0 a bond . Q3b OH
1500 CH S QIc a bond Me a bond NH 0 a bond Q3c OH
1501 CH S QIc a bond H a bond NH S NH Q3a OH
1502 CH S QIc a bond H a bond NH S NH Q3b OH
1503 CH S QIc a bond H a bond NH S NH Q3c OH
1504 CH S QIc a bond H a bond NH S a bond Q3a OH
1505 CH S QIc a bond H a bond NH S a bond Q3b OH
1506 CH S QIc a bond H a bond NH S a bond Q3c OH
1507 CH S QIc a bond H a bond NH 0 NH Q3a OH
1508 CH S QIc a bond H a bond NH 0 NH Q3b OH
1509 CH S QIc a bond H a bond NH 0 NH Q3c OH
1510 CH S QIc a bond H a bond NH 0 a bond Q3a OH
1511 CH S QIc a bond H a bond NH 0 a bond Q3b OH
1512 CH S QIc a bond H a bond NH 0 a bond Q3c OH
1513 CH S QId a bond Me a bond NH S NH Q3a OH
1514 CH S QId a bond Me a bond NH S NH Q3b OH
1515 CH S QId a bond Me a bond NH S NH Q3c OH
1516 CH S QId a bond Me a bond NH S a bond Q3a OH
1517 CH S QId a bond Me a bond NH S a bond Q3b OH
1518 CH S QId a bond Me a bond NH S a bond Q3c OH 1519 CH S QId a bond Me a bond NH 0 NH Q3a OH
1520 CH S QId a bond Me a bond NH 0 NH Q3b OH
1521 CH S QId a bond Me a bond NH 0 NH Q3c OH
1522 CH S QId a bond Me a bond NH 0 a bond Q3a OH
1523' CH S QId a bond Me a bond NH 0 a bond Q3b OH
1524 CH S QId a bond Me a bond NH 0 a bond Q3c OH
1525 CH S QId a bond H a bond NH S NH Q3a OH
1526 CH S QId a bond H a bond NH S NH Q3b OH
1527 CH S QId a bond H a bond NH S NH Q3c OH
1528 CH S QId a bond H a bond NH S a bond Q3a OH
1529 CH S QId a bond H a bond NH S a bond Q3b OH
1530 CH S QId a bond H a bond NH S a bond Q3c OH
1531 CH S QId a bond H a bond NH 0 NH Q3a OH
1532 CH S QId a bond H a bond NH 0 NH Q3b OH
1533 CH S QId a bond H a bond NH 0 NH Q3c OH
1534 CH S QId a bond H a bond NH 0 a bond Q3a OH
1535 CH S QId a bond H a bond NH 0 a bond Q3b OH
1536 CH S QId a bond H a bond NH 0 a bond Q3c OH
1537 CH S QIe a bond Me a bond NH S NH Q3a OH
1538 CH S QIe a bond Me a bond NH S NH Q3b OH
1539 CH S QIe a bond Me a bond NH S NH Q3c OH
1540 CH S QIe a bond Me a bond NH S a bond Q3a OH
1541 CH S QIe a bond Me a bond NH S a bond Q3b OH
1542 CH S QIe a bond Me a bond NH S a bond Q3c OH
1543 CH S QIe a bond Me a bond NH 0 NH Q3a OH
1544 CH S QIe a bond Me a bond NH 0 NH Q3b OH
1545 CH S QIe a bond Me a bond NH 0 NH Q3c OH
1546 CH S QIe a bond Me a bond NH 0 a bond Q3a OH
1547 CH S QIe a bond Me a bond NH 0 a bond Q3b OH
1548 CH S QIe a bond Me a bond NH 0 a bond Q3c OH
1549 CH S QIe a bond H a bond NH S NH Q3a OH
1550 CH S QIe a bond H a bond NH S NH Q3b OH
1551' CH S QIe a bond H a bond NH S NH Q3c OH
1552 CH S QIe a bond H a bond NH S a bond Q3a OH
1553 CH S QIe a bond H a bond NH S a bond Q3b OH
1554 CH S QIe a bond H a bond NH S a bond Q3c OH 1555 CH S QIe a bond H a bond NH O NH Q3a OH
1556 CH S QIe a bond H a bond NH 0 NH Q3b OH
1557 CH S QIe a bond H a bond NH 0 NH Q3c OH
1558 CH S QIe a bond H a bond NH 0 a bond Q3a OH 1559 CH S QIe a bond H a bond NH 0 a bond Q3b OH
1560 CH S QIe a bond H a bond NH 0 a bond Q3c OH
1561 CH S QIf a bond Me a bond NH S NH Q3a OH
1562 CH S QIf a bond Me a bond NH S NH Q3b OH
1563 CH S QIf a bond Me a bond NH. S NH Q3c OH 1564 CH S QIf a bond Me a bond NH S a bond Q3a OH
1565 CH S QIf a bond Me a bond NH S a bond Q3b OH
1566 CH S QIf a bond Me a bond NH S a bond Q3c OH
1567 CH S QIf a bond Me a bond NH 0 NH Q3a OH
1568 CH S QIf a bond Me a bond NH 0 NH Q3b OH 1569 CH S QIf a bond Me a bond NH 0 NH Q3c OH
1570 CH S QIf a bond Me a bond NH 0 a bond Q3a OH
1571 CH S QIf a bond Me a bond NH 0 a bond Q3b OH
1572 CH S QIf a bond Me a bond NH 0 a bond Q3c OH
1573 CH S QIf a' bond H a bond NH S NH Q3a OH 1574 CH S QIf a bond H a bond NH S NH Q3b OH
1575 CH S QIf a bond H a bond NH S NH Q3c OH
1576 CH S QIf a bond H a bond NH S a bond Q3a OH
1577 CH S QIf a bond H a bond NH S a bond Q3b OH
1578 CH S QIf a bond H a bond NH S a bond Q3c OH 1579 CH S QIf a bond H a bond NH 0 NH Q3a OH
1580 CH S QIf a bond H a bond NH 0 NH Q3b OH
1581 CH S QIf a bond H a bond NH 0 NH Q3c OH
1582 CH S QIf a bond H .a bond NH 0 a bond Q3a OH
1583 CH S QIf a bond H a bond NH 0 a bond Q3b OH . 1584 CH S QIf a bond H a bond NH 0 a bond Q3c OH
1585 CH S QIg a bond Me a bond NH S NH Q3a OH
1586 CH S QIg a bond Me" a bond NH S NH Q3b OH
1587 CH S QIg a bond Me a bond NH S NH Q3c OH
1588 CH S QIg a bond Me a bond NH S a bond Q3a OH 1589 CH S QIg a bond Me a bond NH S a bond Q3b OH
1590 CH S QIg a bond Me a bond NH S a bond Q3c OH 1591 CH S QIg a bond Me a bond NH 0 NH Q3a OH
1592 CH S QIg a bond Me a bond NH 0 NH Q3b OH
1593 CH S QIg a bond Me a bond NH 0 NH Q3c OH
1594 CH S QIg a bond Me a bond NH 0 a bond Q3a OH 1595 CH S QIg a bond Me a bond NH 0 a bond Q3b OH
1596 CH S QIg a bond Me a bond NH 0 a bond Q3c OH
1597 CH S QIg a bond H a bond NH S NH Q3a OH
1598 CH S QIg a bond H a bond NH S NH Q3b OH
1599 CH S QIg a bond H a bond NH S NH Q3c OH 1600 CH S QIg a bond H a bond NH S a bond Q3a OH
1601 CH S QIg a bond H a bond NH S a bond Q3b OH
1602 CH S QIg a bond H a bond NH S a bond Q3c OH
1603 CH S QIg a bond H a bond NH 0 NH Q3a OH
1604 CH S QIg a bond H a bond NH 0 NH Q3b OH 1605 CH S QIg a bond H a bond NH 0 NH Q3c OH
1606 CH S QIg a bond H a bond NH 0 a bond Q3a OH
1607 CH S QIg a bond H a bond NH 0 a bond Q3b OH
1608 CH S QIg a bond H a bond NH 0 a bond Q3c OH
1609 CH S QIh a bond Me a bond NH S NH Q3a OH 1610 CH S QIh a bond Me a bond NH S NH Q3b OH
1611 CH S QIh a bond Me a bond NH S NH Q3c OH
1612 CH S QIh a bond Me a bond NH S a bond Q3a OH
1613 CH S QIh a bond Me a bond NH S a bond Q3b OH
1614 CH S QIh a bond Me a bond NH S a bond Q3c OH 1615 CH S QIh a bond Me a bond NH 0 NH Q3a OH
1616 CH S QIh a bond Me a bond NH 0 NH Q3b OH
1617 CH S QIh a bond Me a bond NH 0 NH Q3c OH
1618 CH S QIh a bond Me . a bond NH 0 a bond Q3a OH
1619 CH S QIh a bond Me a bond NH 0 a bond Q3b OH 1620 CH S QIh a bond Me a bond NH 0 a bond Q3c OH
1621 CH S QIh a bond H a bond NH S NH Q3a OH
1622 CH S QIh a bond H a bond NH S NH Q3b OH
1623 CH S QIh a bond H a bond NH S NH Q3c OH
1624 CH S QIh a bond H a bond NH S a bond Q3a OH. 1625 CH S QIh a bond H a bond NH S a bond Q3b OH
1626 CH S QIh a bond H a bond NH S a bond Q3c OH 1627 CH S QIh a bond H a bond NH 0 NH Q3a OH
1628 CH S QIh a bond H a bond NH 0 NH Q3b OH
1629 CH S QIh a bond H a bond NH 0 NH Q3c OH
1630 CH S QIh a bond H a bond NH 0 a bond Q3a OH
5 1631 CH S QIh a bond H a bond NH 0 a bond Q3b OH
1632 CH S QIh a bond H a bond NH 0 a bond Q3c OH
1633 CH S QIi a bond Me a bond NH S NH Q3a OH
1634 CH S QIi a bond Me a bond NH S NH Q3b OH
1635 CH S QIi a bond Me a bond NH S NH Q3c OH
.o 1636 CH S QIi a bond Me a bond NH S a bond I Q3a OH
1637 CH S QIi a bond Me a bond NH S a bond 1 Q3b OH
1638 CH S QIi a bond Me a bond NH S a bond [ Q3c OH
1639 CH S QIi a bond Me a bond NH 0 NH Q3a OH
1640 CH S QIi a bond Me a bond NH 0 NH Q3b OH
.5 1641 CH S QIi a bond Me a bond NH 0 NH Q3c OH
1642 CH S QIi a bond Me a bond NH 0 a bond [ Q3a OH
1643 CH S QIi a bond Me a bond NH 0 a bond 1 Q3b OH
1644 CH S QIi a bond Me a bond NH 0 a bond 1 Q3c OH
1645 CH S QIi a bond H a bond NH S NH Q3a OH so 1646 CH S QIi a bond H a bond NH S NH Q3b OH
1647 CH S QIi a bond H a bond NH S NH Q3c OH
1648 CH S QIi a bond H a bond NH S a bond Q3a OH
1649 CH S QIi a bond H a bond NH S a bond Q3b OH
1650 CH S QIi a bond H a bond NH S a bond Q3c OH
:5 1651 CH S QIi a bond H a bond NH 0 NH Q3a OH
1652 CH S QIi a bond H a bond NH 0 NH Q3b OH
1653 CH S QIi a bond H a bond NH 0 NH Q3c i OH
1654 CH S QIi a bond H a bond NH 0 a bond Q3a OH
1655 CH S QIi a bond H a bond NH 0 a bond Q3b OH
■o 1656 CH S QIi a bond H a bond NH 0 a bond Q3c OH
1657 CH S QIj a bond Me a bond NH S NH Q3a OH
1658 CH S QIj a bond Me a bond NH S NH Q3b OH
1659 CH S QIj a bond Me a bond NH S NH Q3c OH
1660 CH S Qlj a bond Me a bond NH S a bond Q3a OH
5 1661 CH S QIj a bond Me a bond NH S a bond Q3b OH
1662 CH S Qlj a bond Me a bond NH S a bond Q3c OH 1663 CH S QIj a bond Me a bond NH 0 NH Q3a OH
1664 CH S QIj a bond Me a bond NH 0 NH Q3b OH
1665 CH S QIj a bond Me a bond NH 0 NH Q3c OH
1666 CH S QIj a bond Me a bond NH 0 a bond Q3a OH 1667 CH S QIj a bond Me a bond NH 0 a bond Q3b OH
1668 CH S QIj a bond Me a bond NH 0 a bond Q3c OH
1669 CH S QIj a bond H a bond NH S NH Q3a OH
1670 CH S QIj a bond H a bond NH S NH Q3b OH
1671 CH S QIj a bond H a bond NH S NH Q3c OH 1672 CH S QIj a bond H a bond NH S a bond Q3a OH
1673 CH S QIj a bond H a bond NH S a bond Q3b OH
1674 CH S QIj a bond H a bond NH S a bond Q3c OH
1675 CH S QIj a bond H a bond NH 0 NH Q3a OH
1676 CH S QIj a bond H a bond NH 0 NH Q3b OH 1677 CH S QIj a bond H a bond NH 0 NH Q3c OH
1678 CH S QIj a bond H a bond NH 0 a bond Q3a OH
1679 CH S QIj a bond H a bond NH 0 a bond Q3b OH
1680 CH S QIj a bond H a bond NH 0 a bond Q3c OH
1681 CH 0 QIa a bond Me a bond NH S NH Q3a OH 1682 CH 0 QIa a bond Me a bond NH S NH Q3b OH
1683 CH 0 QIa a bond Me a bond NH S NH Q3c OH
1684 CH 0 QIa a bond Me a bond NH S a bond Q3a OH
1685 CH 0 QIa a bond Me a bond NH S a bond Q3b OH
1686 CH 0 QIa a bond Me a bond NH S a bond Q3c OH 1687 CH 0 QIa a bond Me a bond NH 0 NH Q3a OH
1688 CH 0 QIa a bond Me a bond NH 0 NH Q3b OH
1689 CH 0 QIa a bond Me a bond NH 0 NH Q3c OH
1690 CH 0 QIa a bond Me a bond NH 0 a bond Q3a OH
1691 CH 0 QIa a bond Me a bond NH 0 a bond Q3b OH 1692 CH 0 QIa a bond Me a bond NH 0 a bond Q3c OH
1693 CH 0 QIa a bond H a bond NH S NH Q3a OH
1694 CH 0 QIa a bond H a bond NH S NH Q3b OH
1695 CH 0 QIa a bond H a bond NH S NH Q3c OH
1696 CH 0 QIa a bond H a bond NH S a bond Q3a OH 1697 CH 0 QIa a bond H a bond NH S a bond Q3b OH
1698 CH 0 QIa a bond H a bond NH S a bond Q3c OH 1699 CH 0 QIa a bond H a bond NH 0 NH Q3a OH
1700 CH 0 QIa a bond H a bond NH 0 NH Q3b OH
1701 CH 0 QIa a bond H a bond NH 0 NH Q3c OH
1702 CH 0 QIa a bond H a bond NH 0 a bond Q3a OH
1703 CH 0 QIa a bond H a bond NH 0 a bond Q3b OH
1704 CH 0 QIa a bond H a bond NH 0 a bond Q3c OH
1705 CH 0 QIb a bond Me a bond NH S NH Q3a OH
1706 CH 0 QIb a bond Me a bond NH S NH Q3b OH
1707 CH 0 QIb a bond Me a bond NH S NH Q3c OH
1708 CH 0 QIb a bond Me a bond NH S a bond Q3a OH
1709 CH 0 QIb a bond Me a bond NH S a bond Q3b OH
1710 CH 0 QIb a bond Me a bond NH S a bond Q3c OH
1711 CH 0 QIb a bond Me a bond NH 0 NH Q3a OH
1712 CH 0 QIb a bond Me a bond NH 0 NH Q3b OH
1713 CH 0 QIb a bond Me a bond NH 0 NH Q3c OH
1714 CH 0 QIb a bond Me a bond NH 0 a bond Q3a . OH
1715 CH 0 QIb a bond Me a bond NH 0 a bond Q3b OH
1716 CH 0 QIb a bond Me a bond NH 0 a bond Q3c OH
1717 CH 0 QIb a bond H a bond NH S NH Q3a OH
1718 CH 0 QIb a bond H a bond NH S NH Q3b OH
1719 CH 0 QIb a bond H a bond NH S NH Q3c OH
1720 CH 0 QIb a bond H a bond NH S a bond Q3a OH
1721 CH 0 QIb a bond H a bond NH S a bond Q3b OH
1722 CH 0 QIb a bond H a bond NH S a bond Q3c OH
1723 CH 0 QIb a bond H a bond NH 0 NH Q3a OH
1724 CH 0 QIb a bond H a bond NH 0 NH Q3b OH
1725 CH 0 QIb a bond H a bond NH 0 NH Q3c OH
1726 CH 0 QIb a bond H a bond NH 0 a bond Q3a OH
1727 CH 0 QIb a bond H a bond NH 0 a bond Q3b OH
1728 CH 0 QIb a bond H a bond NH 0 a bond Q3c OH
1729 CH 0 QIc a bond Me a bond NH S NH Q3a OH
1730 CH 0 QIc a bond Me a bond NH S NH Q3b OH
1731 CH 0 QIc a bond Me a bond NH S NH Q3c OH
1732 CH 0 QIc a bond Me a bond NH S a bond Q3a OH
1733 CH 0 QIc a bond Me a bond NH S a bond Q3b OH
1734 CH 0 QIc a bond Me a bond NH S a bond Q3c OH 1735 CH 0 QIc a bond Me a bond NH 0 NH Q3a OH
1736 CH 0 QIc a bond Me a bond NH 0 NH Q3b OH
1737 CH 0 QIc a bond Me a bond NH 0 NH Q3c OH
1738 CH 0 QIc a bond Me a bond NH 0 a bond Q3a OH 1739 CH 0 QIc a bond Me a bond NH 0 a bond Q3b OH
1740 CH 0 QIc a bond Me a bond NH 0 a bond Q3c OH
1741 CH 0 QIc a bond H a bond NH S NH Q3a OH
1742 CH 0 QIc a bond H a bond NH S NH Q3b OH
1743 CH 0 QIc a bond H a bond NH S NH Q3c OH 1744 CH 0 QIc a bond H a bond NH S a bond Q3a OH
1745 CH 0 QIc a bond H a bond NH S a bond Q3b OH
1746 CH 0 QIc a bond H a bond NH S a bond Q3c OH
1747 CH 0 QIc a bond H a bond NH 0 NH Q3a OH
1748 CH 0 QIc a bond H a bond NH 0 NH Q3b OH 1749 CH 0 QIc a bond H a bond NH 0 NH Q3c OH
1750 CH 0 QIc a bond H a bond NH 0 a bond Q3a OH
1751 CH 0 QIc a bond H a bond NH 0 a bond Q3b OH
1752 CH 0 QIc a bond H a bond NH 0 a bond Q3c OH
1753 CH 0 QId a bond Me a bond NH S NH Q3a OH 1754 CH 0 QId a bond Me a bond NH S NH Q3b OH
1755 CH 0 QId a bond Me a bond NH S NH Q3c OH
1756 CH 0 QId a bond Me a bond NH S a bond Q3a OH
1757 CH 0 QId a bond Me a bond NH S a bond Q3b OH
1758 CH 0 QId a bond Me a bond NH S a bond Q3c OH 1759 CH 0 QId a bond Me a bond NH 0 NH Q3a OH
1760 CH 0 QId a bond Me a bond NH 0 NH Q3b OH
1761 CH 0 QId a bond Me a bond NH 0 NH Q3c OH
1762 CH 0 QId a bond Me a bond NH 0 a bond Q3a OH
1763 CH 0 QId a bond Me a bond NH 0 a bond Q3b OH 1764 CH 0 QId a bond Me a bond NH 0 a bond Q3c OH
1765 CH 0 QId a bond H a bond NH S NH Q3a OH
1766 CH 0 QId a bond H a bond NH S NH Q3b OH
1767 CH 0 QId a bond H a bond NH S NH Q3c OH
1768 CH 0 QId a bond H a bond NH S a bond Q3a OH 1769 CH 0 QId a bond H a bond NH S a bond Q3b OH
1770 CH 0 QId a bond H a bond NH S a bond Q3c OH 1771 CH 0 QId a bond H a bond NH O NH Q3a OH
1772 CH 0 QId a bond H a bond NH 0 NH Q3b OH
1773 CH 0 QId a bond H a bond NH 0 NH Q3c OH
1774 CH 0 QId a bond H a bond NH 0 a bond Q3a OH 1775 CH 0 QId a bond H a bond 'NH 0 a bond Q3b OH
1776 CH 0 QId a bond H a bond NH 0 a bond Q3c OH
1777 CH 0 QIe a bond Me a bond NH S NH Q3a OH
1778 CH 0 QIe a bond Me a bond NH S NH Q3b OH
1779 CH 0 QIe a bond Me a bond NH S NH Q3c OH 1780 CH 0 QIe a bond Me a bond NH S a bond Q3a OH
1781 CH 0 QIe a bond Me a bond NH S a bond Q3b OH
1782 CH 0 QIe a bond Me a bond NH S a bond Q3c OH
1783 CH 0 QIe a bond Me a bond NH 0 NH Q3a OH
1784 CH 0 QIe a bond Me a bond NH 0 NH Q3b OH 1785 CH 0 QIe a bond Me a bond NH 0 NH Q3c OH
1786 CH 0 QIe a bond Me a bond NH 0 a bond Q3a OH
1787 CH 0 QIe a bond Me a bond NH 0 a bond Q3b OH
1788 CH 0 QIe a bond Me a bond NH 0 a bond Q3c OH
1789 CH 0 QIe a bond H a bond NH S NH Q3a OH 1790 CH 0 QIe a bond H a bond NH S NH Q3b OH
1791 CH 0 QIe a bond H a bond NH S NH Q3c OH
1792 CH 0 QIe a bond H a bond NH S a bond Q3a OH
1793 CH 0 QIe a bond H a ,.bond NH S a bond Q3b OH
1794 CH 0 QIe a bond H a bond NH S a bond Q3c OH 1795 CH 0 QIe a bond H a bond NH 0 NH Q3a OH
1796 CH 0 QIe a bond H a bond NH 0 NH Q3b OH
1797 CH 0 QIe a bond H a bond NH 0 NH Q3c OH
1798 CH 0 QIe a bond H a bond NH 0 a bond Q3a OH
1799 CH 0 QIe a bond H a bond NH 0 a bond Q3b OH 1800 CH 0 QIe a bond H a bond NH 0 a bond Q3c OH
1801 CH 0 QIf a bond Me a bond NH S NH Q3a OH
1802 CH 0 QIf a bond Me a bond NH S NH Q3b OH
1803 CH 0 QIf a bond Me a bond NH S NH Q3c OH
1804 CH 0 QIf a bond Me a bond NH S a bond Q3a OH 1805 CH 0 QIf a bond Me a bond NH S a bond Q3b OH
1806 CH 0 QIf a bond Me a bond NH S a bond Q3c OH 1807 CH 0 QIf a bond Me a bond NH 0 NH Q3a OH
1808 CH 0 QIf a bond Me a bond NH 0 NH Q3b OH
1809 CH 0 QIf a bond Me a bond NH 0 NH Q3c OH
1810 CH 0 QIf a bond Me a bond NH 0 a bond Q3a OH 1811 ' CH 0 QIf a bond Me a bond' NH 0 a bond Q3b OH
1812 CH 0 QIf a bond Me a bond NH 0 a bond Q3c OH
1813 CH 0 QIf a bond H a bond NH S NH Q3a OH
1814 CH 0 QIf a bond H a bond NH S NH Q3b OH
1815 CH 0 QIf a bond H a bond NH .S NH Q3c OH 1816 CH 0 QIf a bond H a bond NH S a bond Q3a OH
1817 CH 0 QIf a bond H a bond NH S a bond Q3b OH
1818 CH 0 QIf a bond H a bond NH S a bond Q3c OH
1819 CH 0 QIf a bond H a bond NH 0 NH Q3a OH
1820 CH 0 QIf a bond H a bond NH 0 NH Q3b OH 1821 CH 0 QIf a bond H a bond NH 0 NH Q3c OH
1822 CH 0 QIf a bond H a bond NH 0 a bond Q3a OH
1823 CH 0 QIf a bond H a bond NH 0 a bond Q3b OH
1824 CH 0 QIf a bond H a bond NH 0 a bond Q3c OH
1825 CH 0 QIg a bond Me a bond NH S NH Q3a OH 1826 CH 0 QIg a bond Me a bond NH S NH Q3b OH
1827' CH 0 QIg a bond Me a bond NH S NH Q3c OH
1828 CH 0 QIg a bond Me a bond NH S a bond Q3a OH
1829 CH 0 QIg a bond Me a bond NH S a bond Q3b OH
1830 CH 0 QIg a bond Me a bond NH S a bond Q3c OH 1831 CH 0 QIg a bond Me a bond NH 0 NH Q3a OH
1832 CH 0 QIg a bond Me a bond NH 0 NH Q3b OH
1833 CH 0 QIg a bond Me a bond NH 0 NH Q3c OH
1834 CH 0 QIg a bond Me . a bond NH 0 a bond Q3a OH
1835 CH 0 QIg a bond Me a bond NH 0 a bond Q3b OH 1836 CH 0 QIg a bond Me a bond NH 0 0 a bond Q3c OH
1837 CH 0 QIg a bond H a bond NH S NH Q3a OH
1838 CH 0 QIg a bond H a bond NH S NH Q3b OH 1839' CH 0 QIg a bond H a bond NH S NH Q3c OH 1840 CH 0 QIg a bond H a bond NH S a bond Q3a OH 1841 CH 0 QIg a bond H a bond NH S a bond Q3b OH
1842 CH 0 QIg a bond H a bond NH S a bond Q3c OH 1843 CH 0 QIg a bond H a bond NH 0 NH Q3a OH
1844 CH 0 QIg a bond H a bond NH 0 NH Q3b OH
1845 CH 0 QIg a bond H a bond NH 0 NH Q3c OH
1846 CH 0 QIg a bond H a bond NH 0 a bond Q3a OH
1847 CH 0 QIg a bond H a bond NH 0 a bond Q3b OH
1848 CH 0 QIg a bond H a bond NH 0 a bond Q3c OH
1849 CH 0 QIh a bond Me a bond NH S NH Q3a OH
1850 CH 0 QIh a bond Me a bond NH S NH Q3b OH
1851 CH 0 QIh a bond Me a bond NH S NH Q3c OH
1852 CH 0 QIh a bond Me a bond NH S a bond . Q3a . OH
1853 CH 0 QIh a bond Me a bond NH S a bond . Q3b OH
1854 CH 0 QIh a bond Me a bond NH S a bond . Q3c OH
1855 CH 0 QIh a bond Me a bond NH 0 NH Q3a OH
1856 CH 0 QIh a bond Me a bond NH 0 NH Q3b OH
1857 CH 0 QIh a bond Me a bond NH 0 NH Q3c OH
1858 CH 0 QIh a bond Me a bond NH 0 a bond . Q3a OH
1859 CH 0 QIh a bond Me a bond NH 0 a bond . Q3b OH
1860 CH 0 QIh a bond Me a bond NH 0 a bond . Q3c OH
1861 CH 0 QIh a bond H a bond NH S NH Q3a OH
1862 CH 0 QIh a bond H a bond NH S NH Q3b OH
1863 CH 0 QIh a bond H a bond NH S NH Q3c OH
1864 CH 0 QIh a bond H a bond NH S a bond Q3a OH
1865 CH 0 QIh a bond H a bond NH S a bond Q3b OH
1866 CH 0 QIh a bond H a bond NH S a bond Q3c OH
1867 CH 0 QIh a bond H a bond NH 0 NH Q3a OH
1868 CH 0 QIh a bond H a bond NH 0 NH Q3b OH
1869 CH 0 QIh a bond H a bond NH 0 NH Q3c OH
1870 CH 0 QIh a bond H a bond NH 0 a bond Q3a OH
1871 CH 0 QIh a bond H a bond NH 0 a bond Q3b OH
1872 CH 0 QIh a bond H a bond NH 0 a bond Q3c OH
1873 CH 0 QIi a bond Me a bond NH S NH Q3a OH
1874 CH 0 QIi a bond Me a bond NH S NH Q3b OH
1875 CH 0 QIi a bond Me a bond NH S NH Q3c OH
1876 CH 0 QIi a bond Me a bond NH S a bond Q3a OH
1877 CH 0 QIi a bond Me a bond NH S a bond Q3b OH
1878 CH 0 QIi a bond Me a bond NH S a bond Q3c OH 1879 CH 0 QIi a bond Me a bond NH 0 NH Q3a OH
1880 CH 0 QIi a bond Me a bond NH 0 NH Q3b OH
1881 CH 0 QIi a bond Me a bond NH 0 NH Q3c OH
1882 CH 0 QIi a bond Me a bond NH 0 a bond Q3a . OH
1883' CH 0 QIi a bond Me a bond NH 0 a bond Q3b OH
1884 CH 0 QIi a bond Me a bond NH 0 a bond Q3c OH
1885 CH 0 QIi a bond H a bond NH S NH Q3a OH
1886 CH 0 QIi a bond H a bond NH S NH Q3b OH
1887 CH 0 QIi a bond H a bond NH. S NH Q3c OH
1888 CH 0 QIi a bond H a bond NH S a bond Q3a OH
1889 CH 0 QIi a bond H a bond NH S a bond Q3b OH
1890 CH 0 QIi a bond H a bond NH S a bond Q3c OH
1891 CH 0 QIi a bond H a bond NH 0 NH Q3a OH
1892 CH 0 QIi a bond H a bond NH 0 NH Q3b OH
1893 CH 0 QIi a bond H a bond NH 0 NH Q3c OH
1894 CH 0 QIi a bond H a bond NH 0 a bond Q3a OH
1895 CH 0 QIi a bond H a bond NH 0 a bond Q3b OH
1896 CH 0 QIi a bond H a bond NH 0 a bond Q3c OH
1897 CH 0 QIj a' bond Me a bond NH S NH Q3a OH
1898 CH 0 QIj a bond Me a bond NH S NH Q3b OH
1899 CH 0 Qij a bond Me a bond NH S NH Q3c OH
1900 CH 0 QIj a bond Me a bond NH S a bond Q3a OH
1901 CH 0 Qij a bond Me a bond NH S a bond Q3b OH
1902 CH 0 Qij a bond Me a bond NH S a bond Q3c OH
1903 CH 0 Qij a bond Me a bond NH 0 NH Q3a OH
1904 CH 0 Qij a bond Me a bond NH 0 NH Q3b OH
1905 CH 0 Qij a bond Me a bond NH 0 NH Q3c OH
1906 CH 0 Qij a bond Me . a bond NH 0 a bond Q3a OH
1907 CH 0 Qij a bond Me a bond NH 0 a bond Q3b OH
1908 CH 0 Qij a bond Me a bond NH 0 a bond Q3c OH
1909 CH 0 Qij a bond H a bond NH S NH Q3a OH
1910 CH 0 Qij a bond H a bond NH S NH Q3b OH
1911 CH 0 Qij a bond H a bond NH S NH Q3c OH
1912 CH 0 Qij a bond H a bond NH S a bond Q3a OH
1913 CH 0 Qij a bond H a bond NH S a bond Q3b OH
1914 CH 0 Qij a bond H a bond NH S a bond Q3c OH 1915 CH 0 QIj a bond H a bond NH 0 NH Q3a OH
1916 CH 0 QIj a bond H a bond NH 0 NH Q3b OH
1917 CH 0 QIj a bond H a bond NH 0 NH Q3c OH
1918 CH 0 QIj a bond H a bond NH 0 a bond Q3a OH 1919 CH 0 QIj a bond H a bond 'NH 0 a bond Q3b OH
1920 CH 0 QIj a bond H a bond NH 0 a bond Q3c OH
1921 CMe NMe QIa a bond Me a bond NH S NH Q3a OH
1922 CMe NMe QIa a bond Me a bond NH S NH Q3b OH
1923 CMe NMe QIa a bond Me a bond NH S NH Q3c OH 1924 CMe NMe QIa a bond Me a bond NH S a bond Q3a OH
1925 CMe NMe QIa a bond Me a bond NH S a bond Q3b OH
1926 CMe NMe QIa a bond Me a bond NH S a bond Q3c OH
1927 CMe NMe QIa a bond Me a bond NH 0 NH Q3a OH
1928 CMe NMe QIa a bond Me a bond NH 0 NH Q3b OH 1929 CMe NMe QIa a bond Me a bond NH 0 NH Q3c OH
1930 CMe NMe QIa a bond Me a bond NH 0 a bond Q3a OH
1931 CMe NMe QIa a bond Me a bond NH 0 a bond Q3b OH
1932 CMe NMe QIa a bond Me a bond NH 0 a bond Q3c OH
1933 CMe NMe QIa a bond H a bond NH S NH Q3a OH 1934 CMe NMe QIa a bond H a bond NH S NH Q3b OH
1935 CMe NMe QIa a bond H a bond NH S NH Q3c OH
1936 CMe NMe QIa a bond H a bond NH S a bond Q3a OH
1937 CMe NMe QIa a bond H a bond NH S a bond Q3b OH
1938 CMe NMe QIa a bond H a bond NH S a bond Q3c OH 1939 CMe NMe QIa a bond H a bond NH 0 NH Q3a OH
1940 CMe NMe QIa a bond H a bond NH 0 NH Q3b OH
1941 CMe NMe QIa a bond H a bond NH 0 NH Q3c OH
1942 CMe NMe QIa a bond H. a bond NH 0 a bond Q3a OH
1943 CMe NMe QIa a bond H a bond NH 0 a bond Q3b OH 1944 CMe NMe QIa a bond H a bond NH 0 a bond Q3c OH
1945 CMe NMe QIb a bond Me a bond NH S NH Q3a OH
1946 CMe- NMe QIb a bond Me a bond NH S NH Q3b OH
1947 CMe NMe QIb a bond Me a bond NH S NH Q3c OH
1948 CMe NMe QIb a bond Me a bond NH S a bond Q3a OH 1949 CMe NMe QIb a bond Me a bond NH S a bond Q3b OH
1950 CMe NMe QIb a bond Me a bond NH S a bond Q3c OH 1951 CMe NMe QIb a bond Me a bond NH 0 NH Q3a OH
1952 CMe NMe QIb a bond Me a bond NH 0 NH Q3b OH
1953 CMe NMe QIb a bond Me a bond NH 0 NH Q3c OH
1954 CMe NMe QIb a bond Me a bond NH 0 a bond Q3a . OH
1955 CMe NMe QIb a bond Me a bond NH 0 a bond Q3b OH
1956 CMe NMe QIb a bond Me a bond NH 0 a bond Q3c OH
1957 CMe NMe QIb a bond H a bond NH S NH Q3a OH
1958 CMe NMe QIb a bond H a bond NH S NH Q3b OH
1959 CMe NMe QIb a bond H a bond NH S NH Q3c OH
1960 CMe NMe QIb a bond H a bond NH S a bond Q3a OH
1961 CMe NMe QIb a bond H a bond NH S a bond Q3b OH
1962 CMe NMe QIb a bond H a bond NH S a bond Q3c OH
1963 CMe NMe QIb a bond H a bond NH 0 NH Q3a OH
1964 CMe NMe QIb a bond H a bond NH 0 NH Q3b OH
1965 CMe NMe QIb a bond H a bond NH 0 NH Q3c OH
1966 CMe NMe QIb a bond H a bond NH 0 a bond Q3a OH
1967 CMe NMe QIb a bond H a bond NH 0 a bond Q3b OH
1968 CMe NMe QIb a bond H a bond NH 0 a bond Q3c OH
1969 CMe NMe QIc a bond Me a bond NH S NH Q3a OH
1970 CMe NMe QIc a bond Me a bond NH S NH Q3b OH
1971 CMe NMe QIc a bond Me a bond NH S NH Q3c OH
1972 CMe NMe QIc a bond Me a bond NH S a bone 1 Q3a OH
1973 CMe NMe QIc a bond Me a bond NH S a bone 1 Q3b OH
1974 CMe NMe QIc a bond Me a bond NH S a bone 1 Q3c OH
1975 CMe NMe QIc a bond Me a bond NH 0 NH Q3a OH
1976 CMe NMe QIc a bond Me a bond NH 0 NH Q3b OH
1977 CMe NMe QIc a bond Me a bond NH 0 NH Q3c OH
1978 CMe NMe QIc a bond Me a bond NH 0 a bone 1 Q3a OH
1979 CMe NMe QIc a bond Me a bond NH 0 a bone 1 Q3b OH
1980 CMe NMe QIc a bond Me a bond NH 0 a bone I Q3c OH
1981 CMe NMe QIc a bond H a bond NH S NH Q3a OH
1982 CMe NMe QIc a bond H a bond NH S NH Q3b OH
1983 CMe NMe QIc a bond H a bond NH S NH Q3c OH
1984 CMe NMe QIc a bond H a bond NH S a bond Q3a OH
1985 CMe NMe QIc a bond H a bond NH S a bond Q3b OH
1986 CMe NMe QIc a bond H a bond NH S a bond Q3c OH 1987 CMe NMe QIc a bond H a bond NH 0 NH Q3a OH
1988 CMe NMe QIc a bond H a bond NH 0 NH Q3b OH
1989 CMe NMe QIc a bond H a bond NH 0 NH Q3c OH
1990 CMe NMe QIc a bond H a bond NH 0 a bond Q3a OH
1991 CMe NMe QIc a bond H a bond NH 0 a bond Q3b OH
1992 CMe NMe QIc a bond H a bond NH 0 a bond Q3c OH
1993 CMe NMe QId a bond Me a bond NH S S N NHH Q Q33aa O OHH
1994 CMe NMe QId a bond Me a bond NH S S N NHH Q Q33bb O OHH
1995 CMe NMe QId a bond Me a bond NH S S N NHH Q Q33cc O OHH
1996 CMe NMe QId a bond Me a bond NH S S aa bboonndd : QQ33aa O OHH
1997 CMe NMe QId a bond Me a bond NH S a bond . Q3b OH
1998 CMe NMe QId a bond Me a bond NH S a bond . Q3c OH
1999 CMe NMe QId a bond Me a bond NH 0 NH Q3a OH
2000 CMe NMe QId a bond Me a bond NH 0 NH Q3b OH
2001 CMe NMe QId a bond Me a bond NH 0 NH Q3c OH
2002 CMe NMe QId a bond Me a bond NH 0 a bond . Q3a OH
2003 CMe NMe QId a bond Me a bond NH 0 a bond . Q3b OH
2004 CMe NMe QId a bond Me a bond NH 0 a bond . Q3c OH
2005 CMe NMe QId a bond H a bond NH S NH Q3a OH
2006 CMe NMe QId a bond H a bond NH S NH Q3b OH
2007 CMe NMe QId a bond H a bond NH S NH Q3c OH
2008 CMe NMe QId a bond H a bond NH S a bond Q3a OH
2009 CMe NMe QId a bond H a bond NH S a bond Q3b OH
2010 CMe NMe QId a bond H a bond NH S a bond Q3c OH
2011 CMe NMe QId a bond H a bond NH 0 NH Q3a OH
2012 CMe NMe QId a bond H a bond NH 0 NH Q3b OH
2013 CMe NMe QId a bond H a bond NH 0 NH Q3c OH
2014 CMe NMe QId a bond H a bond NH 0 a bond Q3a OH
2015 CMe NMe QId a bond H a bond NH 0 a bond Q3b OH
2016 CMe NMe QId a bond H a bond NH 0 a bond Q3c OH
2017 CMe NMe QIe a bond Me a bond NH S NH Q3a OH
2018 CMe NMe QIe a bond Me a bond NH S NH Q3b OH
2019 CMe NMe QIe a bond Me a bond NH S NH Q3c OH
2020 CMe NMe QIe a bond Me a bond NH S a bond Q3a OH
2021 CMe NMe QIe a bond Me a bond NH S a bond Q3b OH
2022 CMe NMe QIe a bond Me a bond NH S a bond Q3c OH 2023 CMe NMe QIe a bond Me a bond NH 0 NH Q3a OH
2024 CMe NMe QIe a bond Me a bond NH 0 NH Q3b OH
2025 CMe NMe QIe a bond Me a bond NH 0 NH Q3c OH
2026 CMe NMe QIe a bond Me a bond NH 0 a bond Q3a OH
2027 CMe NMe QIe a bond Me a bond NH 0 a bond Q3b OH
2028 CMe NMe QIe a bond Me a bond NH 0 a bond Q3c OH
2029 CMe NMe QIe a bond H a bond NH S NH Q3a OH
2030 CMe NMe QIe a bond H a bond NH S NH Q3b OH
2031 CMe NMe QIe a bond H a bond NH. S NH Q3c OH
2032 CMe NMe QIe a bond H a bond NH S a bond Q3a OH
2033 CMe NMe QIe a bond H a bond NH S a bond Q3b OH
2034 CMe NMe QIe a bond H a bond NH S a bond Q3c OH
2035 CMe NMe QIe a bond H a bond NH 0 NH Q3a OH
2036 CMe NMe QIe a bond H a bond NH 0 NH Q3b OH
2037 CMe NMe QIe a bond H a bond NH 0 NH Q3c OH
2038 CMe NMe QIe a bond H a bond NH 0 a bond Q3a OH
2039 CMe NMe QIe a bond H a bond NH 0 a bond Q3b OH
2040 CMe NMe QIe a bond H a bond NH 0 a bond Q3c OH
2041 CMe NMe QIf a bond Me a bond NH S NH Q3a OH
2042 CMe NMe QIf a bond Me a bond NH S NH Q3b OH
2043 CMe NMe QIf a bond Me a bond NH S NH Q3c OH
2044 CMe NMe QIf a bond Me a bond NH S a bond Q3a OH
2045 CMe NMe QIf a bond Me a bond NH S a bond Q3b OH
2046 CMe NMe QIf a bond Me a bond NH S a bond Q3c OH
2047 CMe NMe QIf a bond Me a bond NH 0 NH Q3a OH
2048 CMe NMe QIf a bond Me a bond NH 0 NH Q3b OH
2049 CMe NMe QIf a bond Me a bond NH 0 NH Q3c OH
2050 CMe NMe QIf a bond Me a bond NH 0 a bond Q3a OH
2051 CMe NMe QIf a bond Me a bond NH 0 a bond Q3b OH
2052 CMe NMe QIf a bond Me a bond NH 0 a bond Q3c OH
2053 CMe NMe QIf a bond H a bboonndd N NHH S S N NHH Q Q33aa O OHH
2054 CMe NMe QIf a bond H a bboonndd N NHH S S N NHH Q Q33bb O OHH
2055' CMe NMe QIf a bond H a bboonndd N NHH S S N NHH Q Q33cc O OHH
2056 CMe NMe QIf a bond H a bond NH S a bond Q3a OH
2057 CMe NMe QIf a bond H a bond NH S a bond Q3b OH
2058 CMe NMe QIf a bond H a bond NH S a bond Q3c OH 2059 CMe NMe QIf a bond H a bond NH 0 NH Q3a OH
2060 CMe NMe QIf a bond H a bond NH 0 NH Q3b OH
2061 CMe NMe QIf a bond H a bond NH 0 NH Q3c OH
2062 CMe NMe QIf a bond H a bond NH 0 a bond Q3a OH 2063 CMe NMe QIf a bond H a bond' NH 0 a bond Q3b OH
2064 CMe NMe QIf a bond H a bond NH 0 a bond Q3c OH
2065 CMe NMe QIg a bond Me a bond NH S NH Q3a OH
2066 CMe NMe QIg a bond Me a bond NH S NH Q3b OH
2067 CMe NMe QIg a bond Me a bond NH S NH Q3c OH 2068 CMe NMe QIg a bond Me a bond NH S a bond Q3a OH
2069 CMe NMe QIg a bond Me a bond NH S a bond Q3b OH
2070 CMe NMe QIg a bond Me a bond NH S a bond Q3c OH
2071 CMe NMe QIg a bond Me a bond NH 0 NH Q3a OH
2072 CMe NMe QIg a bond Me a bond NH 0 NH Q3b OH 2073 CMe NMe QIg a bond Me a bond NH 0 NH Q3c OH
2074 CMe NMe QIg a bond Me a bond NH 0 a bond Q3a OH
2075 CMe NMe QIg a bond Me a bond NH 0 a bond Q3b OH
2076 CMe NMe QIg a bond Me a bond NH 0 a bond Q3c OH
2077 CMe NMe QIg a bond H a bond NH S NH Q3a OH 2078 CMe NMe QIg a bond H a bond NH S NH Q3b OH
2079 CMe NMe QIg a bond H a bond NH S NH Q3c OH
2080 CMe NMe QIg a bond H a bond NH S a bond Q3a OH
2081 CMe NMe QIg a bond H a bond NH S a bond Q3b OH
2082 CMe NMe QIg a bond H a bond NH S a bond Q3c OH 2083 CMe NMe QIg a bond H a bond NH 0 NH Q3a OH
2084 CMe NMe QIg a bond H a bond NH 0 NH Q3b OH
2085 CMe NMe QIg a bond H a bond NH 0 NH Q3c OH
2086 CMe NMe QIg a bond H. a bond NH 0 a bond Q3a OH
2087 CMe NMe QIg a bond H a bond NH 0 a bond Q3b OH 2088 CMe NMe QIg a bond H a bond NH 0 a bond Q3c OH
2089 CMe NMe QIh a bond Me a bond NH S NH Q3a OH
2090 CMe NMe QIh a bond Me a bond NH S NH Q3b OH
2091 CMe NMe QIh a bond Me a bond NH S NH Q3c OH
2092 CMe NMe QIh a bond Me a bond NH S a bond Q3a OH 2093 CMe NMe QIh a bond Me a bond NH S a bond Q3b OH
2094 CMe NMe QIh a bond Me a bond NH S a bond Q3c OH 2095 CMe NMe QIh a bond Me a bond NH 0 NH Q3a OH
2096 CMe NMe QIh a bond Me a bond NH 0 NH Q3b OH
2097 CMe NMe QIh a bond Me a bond NH 0 NH Q3c OH
2098 CMe NMe QIh a bond Me a bond NH 0 a bond Q3a OH 2099 CMe NMe QIh a bond Me a bond NH 0 a bond Q3b OH
2100 CMe NMe QIh a bond Me a bond NH 0 a bond Q3c OH
2101 CMe NMe QIh a bond H a bond NH S NH Q3a OH
2102 CMe NMe QIh a bond H a bond NH S NH Q3b OH
2103 CMe NMe QIh a bond H a bond NH S NH Q3c OH 2104 CMe NMe QIh a bond H a bond NH S a bond Q3a OH
2105 CMe NMe QIh a bond H a bond NH S a bond Q3b OH
2106 CMe NMe QIh a bond H a bond NH S a bond Q3c OH
2107 CMe NMe QIh a bond H a bond NH 0 NH Q3a OH
2108 CMe NMe QIh a bond H a bond NH 0 NH Q3b OH 2109 CMe NMe QIh a bond H a bond NH 0 NH Q3c OH
2110 CMe NMe QIh a bond H a bond NH 0 a bond Q3a OH
2111 CMe NMe QIh a bond H a bond NH 0 a bond Q3b OH
2112 CMe NMe QIh a bond H a bond NH 0 a bond Q3c OH
2113 CMe NMe QIi a bond Me a bond NH S NH Q3a OH 2114 CMe NMe QIi a bond Me a bond NH S NH Q3b OH
2115 CMe NMe QIi a bond Me a bond NH S NH Q3c OH
2116 CMe NMe QIi a bond Me a bond NH S a bond Q3a OH
2117 CMe NMe QIi a bond Me a bond NH S a bond Q3b OH
2118 CMe NMe QIi a bond Me a bond NH S a bond Q3c OH 2119 CMe NMe QIi a bond Me a bond NH 0 NH Q3a OH
2120 CMe NMe QIi a bond Me a bond NH 0 NH Q3b OH
2121 CMe NMe QIi a bond Me a bond NH 0 NH Q3c OH
2122 CMe NMe QIi a bond Me a bond NH 0 a bond Q3a OH
2123 CMe NMe QIi a bond Me a bond NH 0 a bond Q3b OH 2124 CMe NMe QIi a bond Me a bond NH 0 a bond Q3c OH
2125 CMe NMe QIi a bond H a bond NH S NH Q3a OH
2126 CMe NMe QIi a bond H a bond NH S NH Q3b OH
2127 CMe NMe QIi a bond H a bond NH S NH Q3c OH
2128 CMe NMe QIi a bond H a bond NH S a bond Q3a OH 2129 CMe NMe QIi a bond H a bond NH S a bond Q3b OH
2130 CMe NMe QIi a bond H a bond NH S a bond Q3c OH 2131 CMe NMe QIi a bond H a bond NH 0 NH Q3a OH
2132 CMe NMe QIi a bond H a bond NH 0 NH Q3b OH
2133 CMe NMe QIi a bond H a bond NH 0 NH Q3c OH
2134 CMe NMe QIi a bond H a bond NH 0 a bond Q3a OH
2135 CMe NMe QIi a bond H a bond NH 0 a bond Q3b OH
2136 CMe NMe QIi a bond H a bond NH 0 a bond Q3c OH
2137 CMe NMe QIj a bond Me a bond NH S NH Q3a OH
2138 CMe NMe QIj a bond Me a bond NH S NH Q3b OH
2139 CMe NMe QIj a bond Me a bond NH S NH Q3c OH
2140 CMe NMe QIj a bond Me a bond NH S a bond Q3a OH
2141 CMe NMe QIj a bond Me a bond NH S a bond Q3b OH
2142 CMe NMe QIj a bond Me a bond NH S a bond Q3c OH
2143 CMe NMe QIj a bond Me a bond NH 0 NH Q3a OH
2144 CMe NMe QIj a bond Me a bond NH 0 NH Q3b OH
2145 CMe NMe QIj a bond Me a bond NH 0 NH Q3c OH
2146 CMe NMe QIj a bond Me a bond NH 0 a bond Q3a OH
2147 CMe NMe QIj a bond Me a bond NH 0 a bond Q3b OH
2148 CMe NMe QIj a bond Me a bond NH 0 a bond Q3c OH
2149 CMe NMe QIj a bond H a bond NH S NH Q3a OH
2150 CMe NMe QIj a bond H a bond NH S NH Q3b OH
2151 CMe NMe QIj a bond H a bond NH S NH Q3c OH
2152 CMe NMe QIj a bond H a bond NH S a bond Q3a OH
2153 CMe NMe QIj a bond H a bond NH S a bond Q3b OH
2154 CMe NMe Qlj a bond H a bond NH S a bond Q3c OH
2155 CMe NMe QIj a bond H a bond NH 0 NH Q3a OH
2156 CMe NMe QIj a bond H a bond NH 0 NH Q3b OH
2157 CMe NMe Qlj a bond H a bond NH 0 NH Q3c OH
2158 CMe NMe Qlj a bond H a bond NH 0 a bond Q3a OH
2159 CMe NMe Qlj a bond H a bond NH 0 a bond Q3b OH
2160 CMe NMe Qlj a bond H a bond NH 0 a bond Q3c OH
2161 CMe NEt QIa a bond Me a bond NH S NH Q3a OH
2162 CMe NEt QIa a bond Me a bond NH S NH Q3b OH
2163 CMe NEt QIa a bond Me a bond NH S NH Q3c OH
2164 CMe NEt QIa a bond Me a bond NH S a bond Q3a OH
2165 CMe NEt QIa a bond Me a bond NH S a bond Q3b OH
2166 CMe NEt QIa a bond Me a bond NH S a bond Q3c OH 2167 CMe NEt QIa a bond Me a bond NH 0 NH Q3a OH
2168 CMe NEt QIa a bond Me a bond NH 0 NH Q3b OH
2169 CMe NEt QIa a bond Me a bond NH 0 NH Q3c OH
2170 CMe NEt QIa a bond Me a bond NH 0 a bond Q3a OH 2171 CMe NEt QIa a bond Me a bond NH 0 a bond Q3b OH
2172 CMe NEt QIa a bond Me a bond NH 0 a bond Q3c OH
2173 CMe NEt QIa a bond H a bond NH S NH Q3a OH
2174 CMe NEt QIa a bond H a bond NH S NH Q3b OH
2175 CMe NEt QIa a bond H a bond NH S NH Q3c OH 2176 CMe NEt QIa a bond H a bond NH S a bond Q3a OH
2177 CMe NEt QIa a bond H a bond NH S a bond Q3b OH
2178 CMe NEt QIa a bond H a bond NH S a bond Q3c OH
2179 CMe NEt QIa a bond H a bond NH 0 NH Q3a OH
2180 CMe NEt QIa a bond H a bond NH 0 NH Q3b OH 2181 CMe NEt QIa a bond H a bond NH 0 NH Q3c OH
2182 CMe NEt QIa a bond H a bond NH 0 a bond Q3a OH
2183 CMe NEt QIa a bond H a bond NH 0 a bond Q3b OH
2184 CMe NEt QIa a bond H a bond NH 0 a bond Q3c OH
2185 CMe NEt QIb a bond Me a bond NH S NH Q3a OH 2186 CMe NEt QIb a bond Me a bond NH S NH Q3b OH
2187 CMe NEt QIb a bond Me a bond NH S NH Q3c OH
2188 CMe NEt QIb a bond Me a bond NH S a bond Q3a OH
2189 CMe NEt QIb a bond Me a bond NH S a bond Q3b OH
2190 CMe NEt QIb a bond Me a bond NH S a bond Q3c OH 2191 CMe NEt QIb a bond Me a bond NH 0 NH Q3a OH
2192 CMe NEt QIb a bond Me a bond NH 0 NH Q3b OH
2193 CMe NEt QIb a bond Me a bond NH 0 NH Q3c OH
2194 CMe NEt QIb a bond Me a bond NH 0 a bond Q3a OH
2195 CMe NEt QIb a bond Me a bond NH 0 a bond Q3b OH 2196 CMe NEt QIb a bond Me a bond NH 0 a bond Q3c OH
2197 CMe NEt QIb a bond H a bond NH S NH Q3a OH
2198 CMe NEt QIb a bond H a bond NH S NH Q3b OH
2199 CMe NEt QIb a bond H a bond NH S NH Q3c OH
2200 CMe NEt QIb a bond H a bond NH S a bond Q3a OH 2201 CMe NEt QIb a bond H a bond NH S a bond Q3b OH
2202 CMe NEt QIb a bond H a bond NH S a bond Q3c OH 2203 CMe NEt QIb a bond H a bond NH 0 NH Q3a OH
2204 CMe NEt QIb a bond H a bond NH 0 NH Q3b OH
2205 CMe NEt QIb a bond H a bond NH 0 NH Q3c OH
2206 CMe NEt QIb a bond H a bond NH 0 a bond Q3a OH 2207 CMe NEt QIb a bond H a bond NH 0 a bond Q3b OH
2208 CMe NEt QIb a bond H a bond NH 0 a bond Q3c OH
2209 CMe NEt QIc a bond Me a bond NH S NH Q3a OH
2210 CMe NEt QIc a bond Me a bond NH S NH Q3b OH
2211 CMe NEt QIc a bond Me a bond NH S NH Q3c OH 2212 CMe NEt QIc a bond Me a bond NH S a bond Q3a OH
2213 CMe NEt QIc a bond Me a bond NH S a bond Q3b OH
2214 CMe NEt QIc a bond Me a bond NH S a bond Q3c OH
2215 CMe NEt QIc a bond Me a bond NH 0 NH Q3a OH
2216 CMe NEt QIc a bond Me a bond NH 0 NH Q3b OH 2217 CMe NEt QIc a bond Me a bond NH 0 NH Q3c OH
2218 CMe NEt QIc a bond Me a bond NH 0 a bond Q3a OH
2219 CMe NEt QIc a bond Me a bond NH 0 a bond Q3b OH
2220 CMe NEt QIc a bond Me a bond NH 0 a bond Q3c OH
2221 CMe NEt QIc a bond H a bond NH S NH Q3a OH 2222 CMe NEt QIc a bond H a bond NH S NH Q3b OH
2223 CMe NEt QIc a bond H a bond NH S NH Q3c OH
2224 CMe NEt QIc a bond H a bond NH S a bond Q3a OH
2225 CMe NEt QIc a bond H a bond NH S a bond Q3b OH
2226 CMe NEt QIc a bond H a bond NH S a bond Q3c OH 2227 CMe NEt QIc a bond H a bond NH 0 NH Q3a OH
2228 CMe NEt QIc a bond H a bond NH 0 NH Q3b OH
2229 CMe NEt QIc a bond H a bond NH 0 NH Q3c OH
2230 CMe NEt QIc a bond H a bond NH 0 a bond Q3a OH
2231 CMe NEt QIc a bond H a bond NH 0 a bond Q3b OH 2232 CMe NEt QIc a bond H a bond NH 0 a bond Q3c OH
2233 CMe NEt QId a bond Me a bond NH S NH Q3a OH
2234 CMe NEt QId a bond Me a bond NH S NH Q3b OH
2235 CMe NEt QId a bond Me a bond NH S NH Q3c OH
2236 CMe NEt QId a bond Me a bond NH S a bond Q3a OH 2237 CMe NEt QId a bond Me a bond NH S a bond Q3b OH
2238 CMe NEt QId a bond Me a bond NH S a bond Q3c OH 2239 CMe NEt QId a bond Me a bond NH O NH Q3a OH
2240 CMe NEt QId a bond Me a bond NH 0 NH Q3b OH
2241 CMe NEt QId a bond Me a bond NH 0 NH Q3c OH
2242 CMe NEt QId a bond Me a bond- NH 0 a bond Q3a OH 2243 CMe NEt QId a bond Me a bond NH 0 a bond Q3b OH
2244 CMe NEt QId a bond Me a bond NH 0 a bond Q3c OH
2245 CMe NEt QId a bond H a bond NH S NH Q3a OH
2246 CMe NEt QId a bond H a bond NH S NH Q3b OH
2247 CMe NEt QId a bond H a bond NH S NH Q3c OH 2248 CMe NEt QId a bond H a bond NH S a bond Q3a OH
2249 CMe NEt QId a bond H a bond NH S a bond Q3b OH
2250 CMe NEt QId a bond H a bond NH S a bond Q3c OH
2251 CMe NEt QId a bond H a bond NH 0 NH Q3a OH
2252 CMe NEt QId a bond H a bond NH 0 NH Q3b OH 2253 CMe NEt QId a bond H a bond NH 0 NH Q3c OH
2254 CMe NEt QId a bond H a bond NH 0 a bond Q3a OH
2255 CMe NEt QId a bond H a bond NH 0 a bond Q3b OH
2256 CMe NEt QId a bond H a bond NH 0 a bond Q3c OH
2257 CMe NEt QIe a bond Me a bond NH S NH Q3a OH 2258 CMe NEt QIe a bond Me a bond NH S NH Q3b OH
2259 CMe NEt QIe a bond Me a bond NH S NH Q3c OH
2260 CMe NEt QIe a bond Me a bond NH S a bond Q3a OH
2261 CMe NEt QIe a bond Me a bond NH S a bond Q3b OH
2262 CMe NEt QIe a bond Me a bond NH S a bond Q3c OH 2263 CMe NEt QIe a bond Me a bond NH 0 NH Q3a OH
2264 CMe NEt QIe a bond Me a bond NH 0 NH Q3b OH
2265 CMe NEt QIe a bond Me a bond NH 0 NH Q3c OH
2266 CMe NEt QIe a bond Me a bond NH 0 a bond Q3a OH
2267 CMe NEt QIe a bond Me a bond NH 0 a bond Q3b OH 2268 CMe NEt QIe a bond Me a bond NH 0 a bond Q3c OH
2269 CMe NEt QIe a bond H a bond NH S NH Q3a OH
2270 CMe NEt QIe a bond H a bond NH S NH Q3b OH
2271 CMe NEt QIe a bond H a bond NH S NH Q3c OH
2272 CMe NEt QIe a bond H a bond NH S a bond Q3a OH 2273 CMe NEt QIe a bond H a bond NH S a bond Q3b OH
2274 CMe NEt QIe a bond H a bond NH S a bond Q3c OH 2275 CMe NEt QIe a bond H a bond NH 0 NH Q3a (3H
2276 CMe NEt QIe a bond H a bond NH 0 NH Q3b ( Έ
2277 CMe NEt QIe a bond H a bond NH 0 NH Q3c ( Έ
2278 CMe NEt QIe a bond H a bond NH 0 a bond Q3a OH
2279 CMe NEt QIe a bond H a bond NH 0 a bond Q3b OH
2280 CMe NEt QIe a bond H a bond NH 0 a bond Q3c OH
2281 CMe NEt QIf a bond Me a bond NH S NH Q3a OH
2282 CMe NEt QIf a bond Me a bond NH S NH Q3b OH
2283 CMe NEt QIf a bond Me a bond NH S NH Q3c OH
2284 CMe NEt QIf a bond Me a bond NH S a bond Q3a OH
2285 CMe NEt QIf a bond Me a bond NH S a bond Q3b OH
2286 CMe NEt QIf a bond Me a bond NH S a bond Q3c OH
2287 CMe NEt QIf a bond Me a bond NH 0 NH Q3a OH
2288 CMe NEt QIf a bond Me a bond NH 0 NH Q3b OH
2289 CMe NEt QIf a bond Me a bond NH 0 NH Q3c OH
2290 CMe NEt QIf a bond Me a bond NH 0 a bond Q3a OH
2291 CMe NEt QIf aa bboonndd Me a bond NH 0 a bond Q3b OH
2292 CMe NEt QIf aa bboonndd Me a bond NH 0 a bond Q3c OH
2293 CMe NEt QIf aa bboonndd H a bond NH S NH Q3a OH
2294 CMe NEt QIf aa bboonndd H a bond NH S NH Q3b OH
2295 CMe NEt QIf aa bboonndd H a bond NH S NH Q3c OH
2296 CMe NEt QIf aa bboonndd H a bond NH S a bond Q3a OH
2297 CMe NEt QIf aa bboonndd H a bond NH S a bond Q3b OH
2298 CMe NEt QIf aa bboonndd H a bond NH S a bond Q3c OH
2299 CMe NEt QIf aa bboonndd H a bond NH 0 NH Q3a OH
2300 CMe NEt QIf aa bboonndd H a bond NH 0 NH Q3b OH
2301 CMe NEt QIf aa bboonndd H a bond NH 0 NH Q3c OH
2302 CMe NEt QIf a bond H a bond NH 0 a bond Q3a OH
2303 CMe NEt QIf a bond H a bond NH 0 a bond Q3b OH
2304 CMe NEt QIf a bond H a bond NH 0 a bond Q3c OH
2305 CMe ^NEt QIg a bond Me a bond NH S NH Q3a OH
2306 CMe NEt QIg a bond Me a bond NH S NH Q3b OH
2307 CMe NEt QIg a bond Me a bond NH S NH Q3c OH
2308 CMe NEt QIg a bond Me a bond NH S a bond Q3a OH
2309 CMe NEt QIg a bond Me a bond NH S a bond Q3b OH
2310 CMe NEt QIg a bond Me a bond S a bond Q3c OH 2311 CMe NEt QIg a bond Me a bond NH 0 NNHH QQ33aa OOHH
2312 CMe NEt Qig a bond Me a bond NH 0 N NHH Q Q33bb O OHH
2313 CMe NEt Qig a bond Me a bond NH 0 N NHH Q Q33cc O OHH
2314 CMe NEt Qig a bond Me a bond NH 0 a bond Q3a OH
2315 CMe NEt Qig a bond Me a bond NH 0 a bond Q3b OH
2316 CMe NEt Qig a bond Me a bond NH 0 a bond Q3c OH
2317 CMe NEt Qig a bond H a bond NH S S N NHH Q Q 33aa 0 OH H
2318 CMe NEt QIg a bond H a bond NH S NH Q3b OH
2319 CMe NEt QIg a bond H a bond NH S NH Q3c OH 2320 CMe NEt QIg a bond H a bond NH S a bond Q3a OH
2321 CMe NEt QIg a bond H a bond NH S a bond Q3b OH
2322 CMe NEt QIg a bond H a bond NH S S a bond Q3c OH
2323 CMe NEt QIg a bond H a bond NH 0 0 NH Q3a OH
2324 CMe NEt QIg a bond H a bond NH 0 0 NH Q3b OH 2325 CMe NEt QIg a bond H a bond NH 0 0 NH Q3c OH
2326 CMe NEt QIg a bond H a bond NH 0 a bond Q3a OH
2327 CMe NEt QIg a bond H a bond NH 0 a bond Q3b OH
2328 CMe NEt QIg a bond H a bond NH 0 a bond Q3c OH
2329 CMe NEt QIh a bond Me a bond NH S NH Q3a OH 2330 CMe NEt QIh a bond Me a bond NH S NH Q3b OH
2331 CMe NEt QIh a bond Me a bond NH S NH Q3c OH
2332 CMe NEt QIh a bond Me a bond NH S a bond Q3ai OH
2333 CMe NEt QIh a bond Me a bond NH S a bond Q3t ) OH
2334 CMe NEt QIh a bond Me a bond NH S a bond Q3c OH 2335 CMe NEt QIh a bond Me a bond NH 0 NH Q3a OH
2336 CMe NEt QIh a bond Me a bond NH 0 NH Q3b OH
2337 CMe NEt QIh a bond Me a bond NH 0 NH Q3c OH
2338 CMe NEt QIh a bond Me a bond NH 0 a bond Q3a OH
2339 CMe NEt QIh a bond Me a bond NH 0 a bond Q3b OH 2340 CMe NEt QIh a bond Me a bond NH 0 a bond Q3c OH
2341 CMe NEt QIh a bond H a bond NH S NH Q3a OH
2342 CMe NEt QIh a bond H a bond NH S NH Q3b OH
2343 CMe NEt QIh a bond H a bond NH S NH Q3c OH
2344 CMe NEt QIh a bond H a bond NH S a bond Q3a OH 2345 CMe NEt QIh a bond H a bond NH S a bond Q3b OH
2346 CMe NEt QIh a bond H a bond NH S a bond Q3c OH 2347 CMe NEt QIh a bond H a bond NH 0 NH Q3a OH
2348 CMe NEt QIh a bond H a bond NH 0 NH Q3b OH
2349 CMe NEt QIh a bond H a bond NH 0 NH Q3c OH
2350 CMe NEt QIh a bond H a bond NH 0 a bond Q3a OH 2351 CMe NEt QIh a bond H a bond NH 0 a bond Q3b OH
2352 CMe NEt QIh a bond H a bond NH 0 a bond Q3c OH
2353 CMe NEt QIi a bond Me a bond NH S NH Q3a OH
2354 CMe NEt QIi a bond Me a bond NH S NH Q3b OH
2355 CMe NEt QIi a bond Me a bond NH S NH Q3c OH 2356 CMe NEt QIi a bond Me a bond NH S a bond Q3a OH
2357 CMe NEt QIi a bond Me a bond NH S a bond Q3b OH
2358 CMe NEt QIi a bond Me a bond NH S a bond Q3c OH
2359 CMe NEt QIi a bond Me a bond NH 0 NH Q3a OH
2360 CMe NEt QIi a bond Me a bond NH 0 NH Q3b OH 2361 CMe NEt QIi a bond Me a bond NH 0 NH Q3c OH
2362 CMe NEt QIi a bond Me a bond NH 0 a bond Q3a OH
2363 CMe NEt QIi a bond Me a bond NH 0 a bond Q3b OH
2364 CMe NEt QIi a bond Me a bond NH 0 a bond Q3c OH
2365 CMe NEt QIi a bond H a bond NH S NH Q3a OH 2366 CMe NEt QIi a bond H a bond NH S NH Q3b OH
2367 CMe NEt QIi a bond H a bond NH S NH Q3c OH
2368 CMe NEt QIi a bond H a bond NH S a bond Q3a OH
2369 CMe NEt QIi a bond H a bond NH S a bond Q3b OH
2370 CMe NEt QIi a bond H a bond NH S a bond Q3c OH 2371 CMe NEt QIi a bond H a bond NH 0 • NH Q3a OH
2372 CMe NEt QIi a bond H a bond NH 0 NH Q3b OH
2373 CMe NEt QIi a bond H a bond NH 0 NH Q3c OH
2374 CMe NEt QIi a bond H. a bond NH 0 a bond Q3a OH
2375 CMe NEt QIi a bond H a bond NH 0 a bond Q3b OH 2376 CMe NEt QIi a bond H a bond NH 0 a bond Q3c OH
2377 CMe NEt QIj a bond Me a bond NH S NH Q3a OH
2378 CMe NEt QIj a bond Me a bond NH S NH Q3b OH 2379' CMe NEt QIj a bond Me a bond NH S NH Q3c OH 2380 CMe NEt QIj a bond Me a bond NH S a bond Q3a OH 2381 CMe NEt QIj a bond Me a bond NH S a bond Q3b OH
2382 CMe NEt QIj a bond Me a bond NH S a bond Q3c OH 2383 CMe NEt Qij a bond Me a bond NH 0 NH Q3a OH
2384 CMe NEt QIj a bond Me a bond NH 0 NH Q3b OH
2385 CMe NEt Qij a bond Me a bond NH 0 NH Q3c OH
2386 CMe NEt QIj a bond Me a bond NH 0 a bond Q3a OH
2387 CMe NEt Qij a bond Me a bond NH 0 a bond Q3b OH
2388 CMe NEt Qij a bond Me a bond NH 0 a bond Q3c OH
2389 CMe NEt Qij a bond H a bond NH S NH Q3a OH
2390 CMe NEt Qij a bond H a bond NH S NH Q3b OH
2391 CMe NEt QIj a bond H a bond NH S NH Q3c OH
2392 CMe NEt Qij a bond H a bond NH S a bond Q3a OH
2393 CMe NEt Qij a bond H a bond NH S a bond Q3b OH
2394 CMe NEt Qij a bond H a bond NH S a bond Q3c OH
2395 CMe NEt Qij a bond H a bond NH 0 NH Q3a OH
2396 CMe NEt Qij a bond H a bond NH 0 NH Q3b OH
2397 CMe NEt Qij a bond H a bond NH 0 NH Q3c OH
2398 CMe NEt Qij a bond H a bond NH 0 a bond Q3a OH
2399 CMe NEt Qij a bond H a bond NH 0 a bond Q3b OH
2400 CMe NEt Qij a bond H a bond NH 0 a bond Q3c OH
2401 CMe S QIa a bond Me a bond NH S NH Q3a OH
2402 CMe S QIa a bond Me a bond NH S NH Q3b OH
2403 CMe S QIa a bond Me a bond NH S NH Q3c OH
2404 CMe S QIa a bond Me a bond NH S a bond Q3a OH
2405 CMe S QIa a bond Me a bond NH S a bond Q3b OH
2406 CMe S QIa a bond Me a bond NH S a bond Q3c OH
2407 CMe S QIa a bond Me a bond NH 0 NH Q3a OH
2408 CMe S QIa a bond Me a bond NH ' 0 NH Q3b OH
2409 CMe S QIa a bond Me a bond NH 0 NH Q3c OH
2410 CMe S QIa a bond Me a bond NH 0 a bond Q3a OH
2411 CMe S QIa a bond Me a bond NH 0 a bond Q3b OH
2412 CMe S QIa a bond Me a bond NH 0 a bond Q3c OH
2413 CMe S QIa a bond H a bond NH S NH Q3a OH
2414 CMe S QIa a bond H a bond NH S NH Q3b OH
2415 CMe S QIa a bond H a bond NH S NH Q3c OH
2416 CMe S QIa a bond H a bond NH S a bond Q3a OH
2417 CMe S QIa a bond H a bond NH S a bond Q3b OH
2418 CMe S QIa a bond H a bond NH S a bond Q3c OH 2419 CMe S QIa a bond H a bond NH 0 NH Q3a OH
2420 CMe S QIa a bond H a bond NH 0 NH Q3b OH
2421 CMe S QIa a bond H a bond NH 0 NH Q3c OH
2422 CMe S QIa a bond H a bond NH 0 a bond Q3a OH
2423 CMe S QIa a bond H a bond NH 0 a bond Q3b OH
2424 CMe S QIa a bond H a bond NH 0 a bond Q3c OH
2425 CMe S QIb a bond Me a bond NH S NH Q3a OH
2426 CMe S QIb a bond Me a bond NH S NH Q3b OH
2427 CMe S QIb a bond Me a bond NH S NH Q3c OH
2428 CMe S QIb a bond Me a bond NH S a bond Q3a OH
2429 CMe S QIb a bond Me a bond NH S a bond Q3b OH
2430 CMe S QIb a bond Me a bond NH S a bond Q3c OH
2431 CMe S QIb a bond Me a bond NH 0 NH Q3a OH
2432 CMe S QIb a bond Me a bond NH 0 NH Q3b OH
2433 CMe S QIb a bond Me a bond NH 0 NH Q3c OH
2434 CMe S QIb a bond Me a bond NH 0 a bond Q3a OH
2435 CMe S QIb a bond Me a bond NH 0 a bond Q3b OH
2436 CMe S QIb a bond Me a bond NH 0 a bond Q3c OH
2437 CMe S QIb a bond H a bond NH S NH Q3a OH
2438 CMe S QIb a bond H a bond NH S NH Q3b OH
2439 CMe S QIb a bond H a bond NH S NH Q3c OH
2440 CMe S QIb a bond H a bond NH S a bond Q3a OH
2441 CMe S QIb a bond H a bond NH S a bond Q3b OH
2442 CMe S QIb a bond H a bond NH S a bond Q3c OH
2443 CMe S QIb a bond H a bond NH 0 NH Q3a OH
2444 CMe S QIb a bond H a bond NH 0 NH Q3b OH
2445 CMe S QIb a bond H a bond NH 0 NH Q3c OH
2446 CMe S QIb a bond H. a bond NH 0 a bond Q3a OH
2447 CMe S QIb a bond H a bond NH 0 a bond Q3b OH
2448 CMe S QIb a bond H a bond NH 0 a bond Q3c OH
2449 CMe S QIc a bond Me a bond NH S NH Q3a OH
2450 CMe S QIc a bond Me a bond NH S NH Q3b OH
2451 CMe S QIc a bond Me a bond NH S NH Q3c OH
2452 CMe S QIc a bond Me a bond NH S a bond Q3a OH
2453 CMe S QIc a bond Me a bond NH S a bond Q3b OH
2454 CMe S QIc a bond Me a bond NH S a bond Q3c OH 2455 CMe S QIc a bond Me a bond NH 0 NH Q3a OH
2456 CMe S QIc a bond Me a bond NH 0 NH Q3b OH
2457 CMe S QIc a bond Me a bond NH 0 NH Q3c OH
2458 CMe S QIc a bond Me a bond NH 0 a bond Q3a OH 2459 CMe S QIc a bond Me a bond NH 0 a bond Q3b OH
2460 CMe S QIc a bond Me a bond NH 0 a bond Q3c OH
2461 CMe S QIc a bond H a bond NH S NH Q3a OH
2462 CMe S QIc a bond H a bond NH S NH Q3b OH
2463 CMe S QIc a bond H a bond NH S NH Q3c OH 2464 CMe S QIc a bond H a bond NH S a bond Q3a OH
2465 CMe S QIc a bond H a bond NH S a bond Q3b OH
2466 CMe S QIc a bond H a bond NH S a bond Q3c OH
2467 CMe S QIc a bond H a bond NH 0 NH Q3a OH
2468 CMe S QIc a bond H a bond NH 0 NH Q3b OH 2469 CMe S QIc a bond H a bond NH 0 NH Q3c OH
2470 CMe S QIc a bond H a bond NH 0 a bond Q3a OH
2471 CMe S QIc a bond H a bond NH 0 a bond Q3b OH
2472 CMe S QIc a bond H a bond NH 0 a bond Q3c OH
2473 CMe S QId a bond Me a bond NH S NH Q3a OH 2474 CMe S QId a bond Me a bond NH S NH Q3b OH
2475 CMe S QId a bond Me a bond NH S NH Q3c OH
2476 CMe S QId a bond Me a bond NH S a bond Q3a OH
2477 CMe S QId a bond Me a bond NH S a bond Q3b OH
2478 CMe S QId a bond Me a bond NH S a bond Q3c OH 2479 CMe S QId a bond Me a bond NH 0 NH Q3a OH
2480 CMe S QId a bond Me a bond NH 0 NH Q3b OH
2481 CMe S QId a bond Me a bond NH 0 NH Q3c OH
2482 CMe S QId a bond Me a bond NH 0 a bond Q3a OH
2483 CMe S QId a bond Me a bond NH 0 a bond Q3b OH 2484 CMe S QId a bond Me a bond NH 0 a bond Q3c OH
2485 CMe S QId a bond H a bond NH S NH Q3a OH
2486 CMe S QId a bond H a bond NH S NH Q3b OH
2487 CMe S QId a bond H a bond NH S NH Q3c OH
2488 CMe S QId a bond H a bond NH S a bond Q3a OH 2489 CMe S QId a bond H a bond NH S a bond Q3b OH
2490 CMe S QId a bond H a bond NH S a bond Q3c OH 2491 CMe S QId a bond H a bond NH 0 NH Q3a OH
2492 CMe S QId a bond H a bond NH 0 NH Q3b OH
2493 CMe S QId a bond H a bond NH 0 NH Q3c OH
2494 CMe S QId a bond H a bond NH 0 a bond Q3a OH
5 2495 CMe S QId a bond H a bond NH 0 a bond Q3b OH
2496 CMe S QId a bond H a bond NH 0 a bond Q3c OH
2497 CMe S QIe a bond Me a bond NH S NH Q3a OH
2498 CMe S QIe a bond Me a bond NH S NH Q3b OH
2499 CMe S QIe a bond Me a bond NH S NH Q3c OH o 2500 CMe S QIe a bond Me a bond NH S a bond Q3a OH
2501 CMe S QIe a bond Me a bond NH S a bond Q3b OH
2502 CMe S QIe a bond Me a bond NH S a bond Q3c OH
2503 CMe S QIe a bond Me a bond NH 0 NH Q3a OH
2504 CMe S QIe a bond Me a bond NH 0 NH Q3b OH
5 2505 CMe S QIe a bond Me a bond NH 0 NH Q3c OH
2506 CMe S QIe a bond Me a bond NH 0 a bond Q3a OH
2507 CMe S QIe a bond Me a bond NH 0 a bond Q3b OH
2508 CMe S QIe a bond Me a bond NH 0 a bond Q3c OH
2509 CMe S QIe a bond H a bond NH S NH Q3a OH o 2510 CMe S QIe a bond H a bond NH S NH Q3b OH
2511 CMe S QIe a bond H a bond NH S NH Q3c OH
2512 CMe S QIe a bond H a bond NH S a bond Q3a OH
2513 CMe S QIe a bond H a bond NH S a bond Q3b OH
2514 CMe S QIe a bond H a bond NH S a bond Q3c OH
5 2515 CMe S QIe a bond H a bond NH 0 NH Q3a OH
2516 CMe S QIe a bond H a bond NH 0 NH Q3b OH
2517 CMe S QIe a bond H a bond NH 0 NH Q3c OH
2518 CMe S QIe a bond H. a bond NH 0 a bond Q3a OH
2519 CMe S QIe a bond H a bond NH 0 a bond Q3b OH o 2520 CMe S QIe a bond H a bond NH 0 a bond Q3c OH
2521 CMe S QIf a bond Me a bond NH S NH Q3a OH
2522 CMe S QIf a bond Me a bond NH S NH Q3b OH
2523' CMe S QIf a bond Me a bond NH S NH Q3c OH
2524 CMe S QIf a bond Me a bond NH S a bond Q3a OH
5 2525 CMe S QIf a bond Me a bond NH S a bond Q3b OH
2526 CMe S QIf a bond Me a bond NH S a bond Q3c OH 2527 CMe S QIf a bond Me a bond NH 0 NH Q3a OH
2528 CMe S QIf a bond Me a bond NH 0 NH Q3b OH
2529 CMe S QIf a bond Me a bond NH 0 NH Q3c OH
2530 CMe S QIf a bond Me a bond NH 0 a bond Q3a . OH
2531 CMe S QIf a bond Me a bond NH 0 a bond Q3b OH
2532 CMe S QIf a bond Me a bond NH 0 a bond Q3c OH
2533 CMe S QIf a bond H a bond NH S NH Q3a OH
2534 CMe S QIf a bond H a bond NH S NH Q3b OH
2535 CMe S QIf a bond H a bond NH S NH Q3c OH
2536 CMe S QIf a bond H a bond NH S a bond Q3a OH
2537 CMe S QIf a bond H a bond NH S a bond Q3b OH
2538 CMe S QIf a bond H a bond NH S a bond Q3c OH
2539 CMe S QIf a bond H a bond NH 0 NH Q3a OH
2540 CMe S QIf a bond H a bond NH 0 NH Q3b OH
2541 CMe S QIf a bond H a bond NH 0 NH Q3c OH
2542 CMe S QIf a bond H a bond NH 0 a bond Q3a OH
2543 CMe S QIf a bond H a bond NH 0 a bond Q3b OH
2544 CMe S QIf a bond H a bond NH 0 a bond Q3c OH
2545 CMe S QIg a bond Me a bond NH S NH Q3a OH
2546 CMe S QIg a bond Me a bond NH S NH Q3b OH
2547 CMe S QIg a bond Me a bond NH S NH Q3c OH
2548 CMe S QIg a bond Me a bond NH S a bond Q3a OH
2549 CMe S QIg a bond Me a bond NH S a bond Q3b OH
2550 CMe S QIg a bond Me a bond NH S a bond Q3c OH
2551 CMe S QIg a bond Me a bond NH 0 NH Q3a OH
2552 CMe S QIg a bond Me a bond NH 0 NH Q3b OH
2553 CMe S QIg a bond Me a bond NH 0 NH Q3c OH
2554 CMe S QIg a bond Me a bond NH 0 a bond Q3a . OH
2555 CMe S QIg a bond Me a bond NH 0 a bond Q3b OH
2556 CMe S QIg a bond Me a bond NH 0 a bond Q3c OH
2557 CMe S Qig a bond H a bond NH S NH Q3a OH
2558 CMe S QIg a bond H a bond NH S NH Q3b OH
2559 CMe S Qig a bond H a bond NH S NH Q3c OH
2560 CMe S Qig a bond H a bond NH S a bond Q3a OH
2561 CMe S Qig a bond H a bond NH S a bond Q3b OH
2562 CMe S QIs a bond H a bond NH S a bond Q3c OH 2563 CMe S QIg a bond H a bond NH 0 NH Q3a OH
2564 CMe S QIg a bond H a bond NH 0 NH Q3b OH
2565 CMe S QIg a bond H a bond NH 0 NH Q3c OH
2566 CMe S QIg a bond H a bond NH 0 a bond Q3a OH
2567 CMe S QIg a bond H a bond NH 0 a bond Q3b OH
2568 CMe S QIg a bond H a bond NH 0 a bond Q3c OH
2569 CMe S QIh a bond Me a bond NH S NH Q3a OH
2570 CMe S QIh a bond Me a bond NH S NH Q3b OH
2571 CMe S QIh a bond Me a bond NH S NH Q3c OH
2572 CMe S QIh a bond Me a bond NH S a bond Q3a OH
2573 CMe S QIh a bond Me a bond NH S a bond Q3b OH
2574 CMe S QIh a bond Me a bond NH S a bond Q3c OH
2575 CMe S QIh a bond Me a bond NH 0 NH Q3a OH
2576 CMe S QIh a bond Me a bond NH 0 NH Q3b OH
2577 CMe S QIh a bond Me a bond NH 0 NH Q3c OH
2578 CMe S QIh a bond Me a bond NH 0 a bond Q3a OH
2579 CMe S QIh a bond Me a bond NH 0 a bond Q3b OH
2580 CMe S QIh a bond Me a bond NH 0 a bond Q3c OH
2581 CMe S QIh a bond H a bond NH S NH Q3a OH
2582 CMe S QIh a bond H a bond NH S NH Q3b OH
2583 CMe S QIh a bond H a bond NH S NH Q3c OH
2584 CMe S QIh a bond H a bond NH S a bond Q3a OH
2585 CMe S QIh a bond H a bond NH S a bond Q3b OH
2586 CMe S QIh a bond H a bond NH S a bond Q3c OH
2587 CMe S QIh a bond H a bond NH 0 NH Q3a OH
2588 CMe S QIh a bond H a bond NH 0 NH Q3b < OH
2589 CMe S QIh a bond H a bond NH 0 NH Q3c i OH
2590 CMe S QIh a bond H. a bond NH 0 a bond Q3a OH
2591 CMe S QIh a bond H a bond NH 0 a bond Q3b OH
2592 CMe S QIh a bond H a bond NH 0 a bond Q3c OH
2593 CMe S QIi a bond Me a bond NH S NH Q3a OH
2594 CMe S QIi a bond Me a bond NH S NH Q3b OH
2595 CMe S QIi a bond Me a bond NH S NH Q3c OH
2596 CMe S QIi a bond Me a bond NH S a bond Q3a OH
2597 CMe S QIi a bond Me a bond NH S a bond Q3b OH
2598 CMe S QIi a bond Me a bond NH S a bond Q3c OH 2599 CMe S QIi a bond Me a bond NH 0 NH Q3a OH
2600 CMe S QIi a bond Me a bond NH 0 NH Q3b OH
2601 CMe S QIi a bond Me a bond NH 0 NH Q3c OH
2602 CMe S QIi a bond Me a bond NH 0 a bond Q3a OH 2603 CMe S QIi a bond Me a bond NH 0 a bond Q3b OH
2604 CMe S QIi a bond Me a bond NH 0 a bond Q3c OH
2605 CMe S QIi a bond H a bond NH S NH Q3a OH
2606 CMe S QIi a bond H a bond NH S NH Q3b OH
2607 CMe S QIi a bond H a bond NH S NH Q3c OH 2608 CMe S QIi a bond H a bond NH S a bond Q3a OH
2609 CMe S QIi a bond H a bond NH S a bond Q3b OH
2610 CMe S QIi a bond H a bond NH S a bond Q3c OH
2611 CMe S QIi a bond H a bond NH 0 NH Q3a OH
2612 CMe S QIi a bond H a bond NH 0 NH Q3b OH 2613 CMe S QIi a bond H a bond NH 0 NH Q3c OH
2614 CMe S QIi a bond H a bond NH 0 a bond Q3a OH
2615 CMe S QIi a bond H a bond NH 0 a bond Q3b OH
2616 CMe S QIi a bond H a bond NH 0 a bond Q3c OH
2617 CMe S QIj a bond Me a bond NH S NH Q3a OH 2618 CMe S QIj a bond Me a bond NH S NH Q3b OH
2619 CMe S QIj a bond Me a bond NH S NH Q3c OH
2620 CMe S QIj a bond Me a bond NH S a bond Q3a OH
2621 CMe S QIj a bond Me a bond NH S a bond Q3b OH
2622 CMe S QIj a bond Me a bond NH S a bond Q3c OH 2623 CMe S QIj a bond Me a bond NH 0 NH Q3a OH
2624 CMe S QIj a bond Me a bond NH 0 NH Q3b OH
2625 CMe S QIj a bond Me a bond NH 0 NH Q3c OH
2626 CMe S QIj a bond Me a bond NH 0 a bond Q3a OH
2627 CMe S QIj a bond Me a bond NH 0 a bond Q3b OH 2628 CMe S QIj a bond Me a bond NH 0 a bond Q3c OH
2629 CMe S QIj a bond H a bond NH S NH Q3a OH
2630 CMe S QIj a bond H a bond NH S NH Q3b OH
2631 CMe S QIj a bond H a bond NH S NH Q3c OH
2632 CMe S QIj a bond H a bond NH S a bond Q3a OH 2633 CMe S QIj a bond H a bond NH S a bond Q3b OH
2634 CMe S QIj a bond H a bond NH S a bond Q3c OH 2635 CMe S QIj a bond H a bond NH 0 NH Q3a OH
2636 CMe S QIj a bond H a bond NH 0 NH Q3b OH
2637 CMe S QIj a bond H a bond NH 0 NH Q3c OH
2638 CMe S QIj a bond H a bond NH 0 a bond Q3a OH 2639 CMe S QIj a bond H a bond' NH 0 a bond Q3b OH
2640 CMe S QIj a bond H a bond NH 0 a bond Q3c OH
2641 CMe 0 QIa a bond Me a bond NH S NH Q3a OH
2642 CMe 0 QIa a bond Me a bond NH S NH Q3b OH
2643 CMe 0 QIa a bond Me a bond NH S NH Q3c OH 2644 CMe 0 QIa a bond Me a bond NH S a bond Q3a OH
2645 CMe 0 QIa a bond Me a bond NH S a bond Q3b OH
2646 CMe 0 QIa a bond Me a bond NH S a bond Q3c OH
2647 CMe 0 QIa a bond Me a bond NH 0 NH Q3a OH
2648 CMe 0 QIa a bond Me a bond NH 0 NH Q3b OH 2649 CMe 0 QIa a bond Me a bond NH 0 NH Q3c OH
2650 CMe 0 QIa a bond Me a bond NH 0 a bond Q3a OH
2651 CMe 0 QIa a bond Me a bond NH 0 a bond Q3b OH
2652 CMe 0 QIa a bond Me a bond NH 0 a bond Q3c OH
2653 CMe 0 QIa a bond H a bond NH S NH Q3a OH 2654 CMe 0 QIa a bond H a bond NH S NH Q3b OH
2655 CMe 0 QIa a bond H a bond NH S NH Q3c OH
2656 CMe 0 QIa a bond H a bond NH S a bond Q3a OH
2657 CMe 0 QIa a bond H a bond NH S a bond Q3b OH
2658 CMe 0 QIa a bond H a bond NH S a bond Q3c OH 2659 CMe 0 QIa a bond H a bond NH 0 NH Q3a OH
2660 CMe 0 QIa a bond H a bond NH 0 NH Q3b OH
2661 CMe 0 QIa a bond H a bond NH 0 NH Q3c OH
2662 CMe 0 QIa a bond H. a bond NH 0 a bond Q3a OH
2663 CMe 0 QIa a bond H a bond NH 0 a bond Q3b OH 2664 CMe 0 QIa a bond H a bond NH 0 a bond Q3c OH
2665 CMe 0 QIb a bond Me a bond NH S NH Q3a OH
2666 CMe 0 QIb a bond Me a bond NH S NH Q3b OH
2667 CMe 0 QIb a bond Me a bond NH S NH Q3c OH
2668 CMe 0 QIb a bond Me a bond NH S a bond Q3a OH 2669 CMe 0 QIb a bond Me a bond NH S a bond Q3b OH
2670 CMe 0 QIb a bond Me a bond NH S a bond Q3c OH 2671 CMe 0 QIb a bond Me a bboonndd NNHH 00 NNHH QQ33aa OOHH
2672 CMe 0 QIb a bond Me a bboonndd N NHH 0 0 N NHH Q Q33bb O OHH
2673 CMe 0 QIb a bond Me a bboonndd N NHH 0 0 N NHH Q Q33cc O OHH
2674 CMe 0 QIb a bond Me a bond NH 0 a bond Q3a . OH
2675 CMe 0 QIb a bond Me a bond NH 0 a bond Q3b OH
2676 CMe 0 QIb a bond Me a bond NH 0 a bond Q3c OH
2677 CMe 0 QIb a bond H a bond NH S NH Q3a OH
2678 CMe 0 QIb a bond H a bond NH S NH Q3b OH
2679 CMe 0 QIb a bond H a bond NH S NH Q3c OH
2680 CMe 0 QIb a bond H a bond NH S a bond Q3a OH
2681 CMe 0 QIb a bond H a bond NH S a bond Q3b OH
2682 CMe 0 QIb a bond H a bond NH S a bond Q3c OH
2683 CMe 0 QIb a bond H a bond NH 0 NH Q3a OH
2684 CMe 0 QIb a bond H a bond NH 0 NH Q3b OH
2685 CMe 0 QIb a bond H a bond NH 0 NH Q3c OH
2686 CMe 0 QIb a bond H a bond NH 0 a bond Q3a OH
2687 CMe 0 QIb a bond H a bond NH 0 a bond Q3b OH
2688 CMe 0 QIb a bond H a bond NH 0 a bond Q3c OH
2689 CMe 0 QIc a bond Me a bond NH S NH Q3a OH
2690 CMe 0 QIc a bond Me a bond NH S NH Q3b OH
2691 CMe 0 QIc a bond Me a bond NH S NH Q3c OH
2692 CMe 0 QIc a bond Me a bond NH S a bond Q3a OH
2693 CMe 0 QIc a bond Me a bond NH S a bond Q3b OH
2694 CMe 0 QIc a bond Me a bond NH S a bond Q3c OH
2695 CMe 0 QIc a bond Me a bond NH 0 NH Q3a OH
2696 CMe 0 QIc a bond Me a bond NH 0 NH Q3b OH
2697 CMe 0 QIc a bond Me a bond NH 0 NH Q3c OH
2698 CMe 0 QIc a bond Me a bond NH 0 a bond Q3a OH
2699 CMe 0 QIc a bond Me a bond NH 0 a bond Q3b OH
2700 CMe 0 QIc a bond Me a bond NH 0 a bond Q3c OH
2701 CMe 0 QIc a bond H a bond NH S NH Q3a OH
2702 CMe 0 QIc a bond H a bond NH S NH Q3b OH
2703 CMe 0 QIc a bond H a bond NH S NH i Q3c OH
2704 CMe 0 QIc a bond H a bond NH S a bond Q3a OH
2705 CMe 0 QIc a bond H a bond NH S a bond Q3b OH
2706 CMe 0 QIc a bond H a bond NH S a bond Q3c OH 2707 CMe 0 QIc a bond H a bond NH 0 NH Q3a OH
2708 CMe 0 QIc a bond H a bond NH 0 NH Q3b OH
2709 CMe 0 QIc a bond H a bond NH 0 NH Q3c OH
2710 CMe 0 QIc a bond H a bond NH 0 a bond Q3a OH 2711 CMe 0 QIc a bond H a bond NH 0 a bond Q3b OH
2712 CMe 0 QIc a bond H a bond NH 0 a bond Q3c OH
2713 CMe 0 QId a bond Me a bond NH S NH Q3a OH
2714 CMe 0 QId a bond Me a bond NH S NH Q3b OH
2715 CMe 0 QId a bond Me a bond NH S NH Q3c OH 2716 CMe 0 QId a bond Me a bond NH S a bond Q3a OH
2717 CMe 0 QId a bond Me a bond NH S a bond Q3b OH
2718 CMe 0 QId a bond Me a bond NH S a bond Q3c OH
2719 CMe 0 QId a bond Me a bond NH 0 NH Q3a OH
2720 CMe 0 QId a bond Me a bond NH 0 NH Q3b OH 2721 CMe 0 QId a bond Me a bond NH 0 NH Q3c OH
2722 CMe 0 QId a bond Me a bond NH 0 a bond Q3a OH
2723 CMe 0 QId a bond Me a bond NH 0 a bond Q3b OH
2724 CMe 0 QId a bond Me a bond NH 0 a bond Q3c OH
2725 CMe 0 QId a bond H a bond NH S NH Q3a OH 2726 CMe 0 QId a bond H a bond NH S NH Q3b OH
2727 CMe 0 QId a bond H a bond NH S NH Q3c OH
2728 CMe 0 QId a bond H a bond NH S a bond Q3a OH
2729 CMe 0 QId a bond H a bond NH S a bond Q3b OH
2730 CMe 0 QId a bond H a bond NH S a bond Q3c OH 2731 CMe 0 QId a bond H a bond NH 0 NH Q3a OH
2732 CMe 0 QId a bond H a bond NH 0 NH Q3b OH
2733 CMe 0 QId a bond H a bond NH 0 NH Q3c OH
2734 CMe 0 QId a bond H a bond NH 0 a bond Q3a OH
2735 CMe 0 QId a bond H a bond NH 0 a bond Q3b OH 2736 CMe 0 QId a bond H a bond NH 0 a bond Q3c OH
2737 CMe 0 QIe a bond Me a bond NH S NH Q3a OH
2738 CMe 0 QIe a bond Me a bond NH S NH Q3b OH
2739 CMe 0 QIe a bond Me a bond NH S NH Q3c OH
2740 CMe 0 QIe a bond Me a bond NH S a bond Q3a OH 2741 CMe 0 QIe a bond Me a bond NH S a bond Q3b OH
2742 CMe 0 QIe a bond Me a bond NH S a bond Q3c OH 2743 CMe 0 QIe a bond Me a bond NH 0 NH Q3a OH
2744 CMe 0 QIe a bond Me a bond NH 0 NH Q3b OH
2745 CMe 0 QIe a bond Me a bond NH 0 NH Q3c OH
2746 CMe 0 QIe a bond Me a bond NH 0 a bond Q3a OH 2747 CMe 0 QIe a bond Me a bond NH 0 a bond Q3b OH
2748 CMe 0 QIe a bond Me a bond NH 0 a bond Q3c OH
2749 CMe 0 QIe a bond H a bond NH S NH Q3a OH
2750 CMe 0 QIe a bond H a bond NH S NH Q3b OH
2751 CMe 0 QIe a bond H a bond NH S NH Q3c OH 2752 CMe 0 QIe a bond H a bond NH S a bond Q3a OH
2753 CMe 0 QIe a bond H a bond NH S a bond Q3b OH
2754 CMe 0 QIe a bond H a bond NH S a bond Q3c OH
2755 CMe 0 QIe a bond H a bond NH 0 NH Q3a OH
2756 CMe 0 QIe a bond H a bond NH 0 NH Q3b OH 2757 CMe 0 QIe a bond H a bond NH 0 NH Q3c OH
2758 CMe 0 QIe a bond H a bond NH 0 a bond Q3a OH
2759 CMe 0 QIe a bond H a bond NH 0 a bond Q3b OH
2760 CMe 0 QIe a bond H a bond NH 0 a bond Q3c OH
2761 CMe 0 QIf a bond Me a bond NH S NH Q3a OH 2762 CMe 0 QIf a bond Me a bond NH S NH Q3b OH
2763 CMe 0 QIf a bond Me a bond NH S NH Q3c OH
2764 CMe 0 QIf a bond Me a bond NH S a bond Q3a OH
2765 CMe 0 QIf a bond Me a bond NH S a bond Q3b OH
2766 CMe 0 QIf a bond Me a bond NH S a bond Q3c OH 2767 CMe 0 QIf a bond Me a bond NH 0 NH Q3a OH
2768 CMe 0 QIf a bond Me a bond NH 0 NH Q3b OH
2769 CMe 0 QIf a bond Me a bond NH 0 NH Q3c OH
2770 CMe 0 QIf a bond Me a bond NH 0 a bond Q3a OH
2771 CMe 0 QIf a bond Me a bond NH 0 a bond Q3b OH 2772 CMe 0 QIf a bond Me a bond NH 0 a bond Q3c OH
2773 CMe 0 QIf a bond H a bond NH S NH Q3a OH
2774 CMe 0 QIf a bond H a bond NH S NH Q3b OH
2775 CMe 0 QIf a bond H a bond NH S NH Q3c OH
2776 CMe 0 QIf a bond H a bond NH S a bond Q3a OH 2777 CMe 0 QIf a bond H a bond NH S a bond Q3b OH
2778 CMe 0 QIf a bond H a bond NH S a bond Q3c OH 2779 CMe 0 QIf a bond H a bond NH 0 NH Q3a OH
2780 CMe 0 QIf a bond H a bond NH 0 NH Q3b OH
2781 CMe 0 QIf a bond H a bond NH 0 NH Q3c OH
2782 CMe 0 QIf a bond H a bond NH 0 a bond Q3a OH
2783 CMe 0 QIf a bond H a bond NH 0 a bond Q3b OH
2784 CMe 0 QIf a bond H a bond NH 0 a bond Q3c OH
2785 CMe 0 QIg a bond Me a bond NH S NH Q3a OH
2786 CMe 0 QIg a bond Me a bond NH S NH Q3b OH
2787 CMe 0 QIg a bond Me a bond NH S NH Q3c OH
2788 CMe 0 QIg a bond Me a bond NH S a bond Q3a . OH
2789 CMe 0 QIg a bond Me a bond NH S a bond Q3b OH
2790 CMe 0 QIg a bond Me a bond NH S a bond Q3c OH
2791 CMe 0 QIg a bond Me a bond NH 0 NH Q3a OH
2792 CMe 0 QIg a bond Me a bond NH 0 NH Q3b OH
2793 CMe 0 QIg a bond Me a bond NH 0 NH Q3c OH
2794 CMe 0 QIg a bond Me a bond NH 0 a bond Q3a OH
2795 CMe 0 QIg a bond Me a bond NH 0 a bond Q3b OH
2796 CMe 0 QIg a bond Me a bond NH 0 a bond Q3c OH
2797 CMe 0 QIg a bond H a bond NH S NH Q3a OH
2798 CMe 0 QIg a bond H a bond NH S NH Q3b OH
2799 CMe 0 QIg a bond H a bond NH S NH Q3c OH
2800 CMe 0 QIg a bond H a bond NH S a bond Q3a OH
2801 CMe 0 QIg a bond H a bond NH S a bond Q3b OH
2802 CMe 0 QIg a bond H a bond NH S a bond Q3c OH
2803 CMe 0 QIg a bond H a bond NH 0 NH Q3a OH
2804 CMe 0 QIg a bond H a bond NH 0 NH Q3b OH
2805 CMe 0 QIg a bond H a bond NH 0 NH Q3c OH
2806 CMe 0 QIg a bond H. a bond NH 0 a bond Q3a OH
2807 CMe 0 QIg a bond H a bond NH 0 a bond Q3b OH
2808 CMe 0 QIg a bond H a bond NH 0 a bond Q3c OH
2809 CMe 0 QIh a bond Me a bond NH S NH Q3a OH
2810 CMe 0 QIh a bond Me a bond NH S NH Q3b OH
2811' CMe 0 QIh a bond Me a bond NH S NH Q3c OH
2812 CMe 0 QIh a bond Me a bond NH S a bond Q3a OH
2813 CMe 0 QIh a bond Me a bond NH S a bond Q3b OH
2814 CMe 0 QIh a bond Me a bond NH S a bond Q3c OH 2815 CMe 0 QIh a bond Me a bond NH 0 NH Q3a OH
2816 CMe 0 QIh a bond Me a bond NH 0 NH Q3b OH
2817 CMe 0 QIh a bond Me a bond NH 0 NH Q3c OH
2818 CMe 0 QIh a bond Me a bond NH 0 a bond Q3a OH
2819 CMe 0 QIh a bond Me a bond NH 0 a bond Q3b OH
2820 CMe 0 QIh a bond Me a bond NH 0 a bond Q3c OH
2821 CMe 0 QIh a bond H a bond NH S NH Q3a OH
2822 CMe 0 QIh a bond H a bond NH S NH Q3b OH
2823 CMe 0 QIh a bond H a bond NH S NH Q3c OH
2824 CMe 0 QIh a bond H a bond NH S a bond Q3a OH
2825 CMe 0 QIh a bond H a bond NH S a bond Q3b OH
2826 CMe 0 QIh a bond H a bond NH S a bond Q3c OH
2827 CMe 0 QIh a bond H a bond NH 0 NH Q3a OH
2828 CMe 0 QIh a bond H a bond NH 0 NH Q3b OH
2829 CMe 0 QIh a bond H a bond NH 0 NH Q3c OH
2830 CMe 0 QIh a bond H a bond NH 0 a bond Q3a OH
2831 CMe 0 QIh a bond H a bond NH 0 a bond Q3b OH
2832 CMe 0 QIh a bond H a bond NH 0 a bond Q3c OH
2833 CMe 0 QIi a bond Me a bond NH S NH Q3a OH
2834 CMe 0 QIi a bond Me a bond NH S NH Q3b OH
2835 CMe 0 QIi a bond Me a bond NH S NH Q3c OH
2836 CMe 0 QIi a bond Me a bond NH S a bond Q3a OH
2837 CMe 0 QIi a bond Me a bond NH S a bond Q3b OH
2838 CMe 0 QIi a bond Me a bond NH S a bond Q3c OH
2839 CMe 0 QIi a bond Me a bond NH 0 NH Q3a OH
2840 CMe 0 QIi a bond Me a bond NH 0 NH Q3b OH
2841 CMe 0 QIi a bond Me a bond NH 0 NH Q3c OH
2842 CMe 0 QIi a bond Me a bond NH 0 a bond Q3a OH
2843 CMe 0 QIi a bond Me a bond NH 0 a bond Q3b OH
2844 CMe 0 QIi a bond Me a bond NH 0 a bond Q3c OH
2845 CMe 0 QIi a bond H a bond NH S NH Q3a i OH
2846 CMe 0 QIi a bond H a bond NH S NH Q3b i OH
2847' CMe 0 QIi a bond H a bond NH S NH Q3c i OH
2848 CMe 0 QIi a bond H a bond NH S a bond Q3a OH
2849 CMe 0 QIi a bond H a bond NH S a bond Q3b OH
2850 CMe 0 QIi a bond H a bond NH S a bond Q3c OH 2851 CMe 0 QIi a bond H a bond NH 0 NH Q3a OH
2852 CMe 0 QIi a bond H a bond NH 0 NH Q3b OH
2853 CMe 0 QIi a bond H a bond NH 0 NH Q3c OH
2854 CMe 0 QIi a bond H a bond NH 0 a bond Q3a OH
2855 CMe 0 QIi a bond H a bond NH 0 a bond Q3b OH
2856 CMe 0 QIi a bond H a bond NH 0 a bond Q3c OH
2857 CMe 0 QIj a bond Me a bond NH S NH Q3a OH
2858 CMe 0 QIj a bond Me a bond NH S NH Q3b OH
2859 CMe 0 QIj a bond Me a bond NH S NH Q3c OH
2860 CMe 0 QIj a bond Me a bond NH S a bond Q3a OH
2861 CMe 0 QIj a bond Me a bond NH S a bond Q3b OH
2862 CMe 0 QIj a bond Me a bond NH S a bond Q3c OH
2863 CMe 0 Qij a bond Me a bond NH 0 NH Q3a OH
2864 CMe 0 QIj a bond Me a bond NH 0 NH Q3b OH
2865 CMe 0 Qij a bond Me a bond NH 0 NH Q3c OH
2866 CMe 0 Qij a bond Me a bond NH 0 a bond Q3a OH
2867 CMe 0 Qij a bond Me a bond NH 0 a bond Q3b OH
2868 CMe 0 Qij a bond Me a bond NH 0 a bond Q3c OH
2869 CMe 0 Qij a bond H a bond NH S NH Q3a OH
2870 CMe 0 Qij a bond H a bond NH S NH Q3b OH
2871 CMe 0 Qij a bond H a bond NH S NH Q3c OH
2872 CMe 0 Qij a bond H a bond NH S a bond Q3a OH
2873 CMe 0 Qij a bond H a bond NH S a bond Q3b OH
2874 CMe 0 Qij a bond H a bond NH S a bond Q3c OH
2875 CMe 0 QIj a bond H a bond NH 0 NH Q3a OH
2876 CMe 0 Qij a bond H a bond NH 0 NH Q3b OH
2877 CMe 0 QIj a bond H a bond NH 0 NH Q3c OH
2878 CMe 0 Qij a bond H a bond NH 0 a bond Q3a OH
2879 CMe 0 Qij a bond H a bond NH 0 a bond Q3b OH
2880 CMe 0 Qij a bond H a bond NH 0 a bond Q3c OH
2881 N NMe QIk a bond Me a bond NH 0 a bond Q3a OH
2882 N NMe QIk a bond Me a bond NH 0 a bond Q3d OH
2883 N NMe QIk a bond Me a bond NH 0 a bond Q3e OH
2884 N NMe QIk a bond Me a bond NH 0 a bond Q3f OH
2885 N NMe QIk a bond Me a bond NH 0 NH' Q3a OH
2886 N NMe QIk a bond Me a bond NH 0 NH Q3d OH 2887 N NMe QIk a bond Me a bond NH 0 NH Q3e OH
2888 N NMe QIk a bond Me a bond NH 0 NH Q3f OH
2889 N NMe QIk a bond Me a bond NH S a bond Q3a OH
2890 N NMe QIk a bond Me a bond NH S a bond Q3d OH 2891 N NMe QIk a bond Me a bond NH S a bond Q3e OH
2892 N NMe QIk a bond Me a bond NH S a bond Q3f OH
2893 N NMe QIk a bond Me a bond NH S NH Q3a OH
2894 N NMe QIk a bond Me a bond NH S NH Q3d OH
2895 N NMe QIk a bond Me a bond NH S NH Q3e OH 2896 N NMe QIk a bond Me a bond NH S NH Q3f OH
2897 N NMe QIl a bond Me a bond NH 0 a bond Q3a OH
2898 N NMe QIl a bond Me a bond NH 0 a bond Q3d OH
2899 N NMe QIl a bond Me a bond NH 0 a bond Q3e OH
2900 N NMe QIl a bond Me a bond NH 0 a bond Q3f OH 2901 N NMe QIl a bond Me a bond NH 0 NH Q3a OH
2902 N NMe QIl a bond Me a bond NH 0 NH Q3d OH
2903 N NMe QIl a bond Me a bond NH 0 NH Q3e OH
2904 N NMe QIl a bond Me a bond NH 0 NH Q3f OH
2905 N NMe QIl a bond Me a bond NH S a bond Q3a OH 2906 N NMe QIl a bond Me a bond NH S a bond Q3d OH
2907 N NMe QIl a bond Me a bond NH S a bond Q3e OH
2908 N. NMe QIl a bond Me a bond NH S a bond Q3f OH
2909 N NMe QIl a bond Me a bond NH S NH Q3a OH
2910 N NMe QIl a bond Me a bond NH S NH Q3d OH 2911 N NMe QIl a bond Me a bond NH S NH Q3e OH
2912 N NMe QH a bond Me a bond NH S NH Q3f OH
2913 N NMe QIm a bond Me a bond NH 0 a bond Q3a OH
2914 N NMe QIm a bond Me a bond NH 0 a bond Q3d OH
2915 N NMe QIm a bond Me a bond NH 0 a bond Q3e OH 2916 N NMe QIm a bond Me a bond NH 0 a bond Q3f OH
2917 N NMe QIm a bond Me a bond NH 0 NH Q3a OH
2918 N NMe QIm a bond Me a bond NH 0 NH Q3d OH 2919' N NMe QIm a bond Me a bond NH 0 NH Q3e OH 2920 N NMe QIm a bond Me a bond NH 0 NH Q3f OH 2921 N NMe QIm a bond Me a bond NH S a bond Q3a OH
2922 N NMe QIm a bond Me a bond NH S a bond Q3d OH 2923 N NMe QIm a bond Me a bond NH S a bond Q3e OH
2924 N NMe QIm a bond Me a bond NH S a bond Q3f OH
2925 N NMe QIm a bond Me a bond NH S NH Q3a OH
2926 N NMe QIm a bond Me a bond NH S NH Q3d OH 2927 N NMe QIm a bond Me a bond NH S NH Q3e OH
2928 N NMe QIm a bond Me a bond NH S NH Q3f OH
2929 N NMe QIn a bond Me a bond NH 0 a bond Q3a OH
2930 N NMe QIn a bond Me a bond NH 0 a bond Q3d OH
2931 N NMe QIn a bond Me a bond NH 0 a bond Q3e OH 2932 N NMe QIn a bond Me a bond NH 0 a bond Q3f OH
2933 N NMe QIn a bond Me a bond NH 0 NH Q3a OH
2934 N NMe QIn a bond Me a bond NH 0 NH Q3d OH
2935 N NMe QIn a bond Me a bond NH 0 • NH Q3e OH
2936 N NMe QIn a bond Me a bond NH 0 NH Q3f OH 2937 N NMe QIn a bond Me a bond NH S a bond Q3a OH
2938 N NMe QIn a bond Me a bond NH S a bond Q3d OH
2939 N NMe QIn a bond Me a bond NH S a bond Q3e OH
2940 N NMe QIn a bond Me a bond NH S a bond Q3f OH
2941 N NMe QIn a bond Me a bond NH S NH Q3a OH 2942 N NMe QIn a bond Me a bond NH S NH Q3d OH
2943 N NMe QIn a bond Me a bond NH S NH Q3e OH
2944 N NMe QIn a bond Me a bond NH S NH Q3f OH
2945 N NEt QIk a bond Me a bond NH 0 a bond Q3a OH
2946 N NEt QIk a bond Me a bond NH 0 a bond Q3d OH 2947 N NEt QIk a bond Me a bond NH 0 a bond Q3e OH
2948 N NEt QIk a bond Me a bond NH 0 a bond Q3f OH
2949 N NEt QIk a bond Me a bond NH 0 NH Q3a OH
2950 N NEt QIk a bond Me a bond NH 0 NH Q3d OH
2951 N NEt QIk a bond Me a bond NH 0 NH Q3e OH 2952 N NEt QIk a bond Me a bond NH 0 NH Q3f OH
2953 N NEt QIk a bond Me a bond NH S a bond Q3a OH
2954 N NEt QIk a bond Me a bond NH S a bond Q3d OH
2955 N NEt QIk a bond Me a bond NH S a bond Q3e OH
2956 N NEt QIk a bond Me a bond NH S a bond Q3f OH 2957 N NEt QIk a bond Me a bond NH S NH Q3a OH
2958 N NEt QIk a bond Me a bond NH S NH Q3d OH 2959 N NEt QIk a bond Me a bond NH S NH Q3e OH
2960 N NEt QIk a bond Me a bond NH S NH Q3f OH
2961 N NEt QIl a bond Me a bond NH 0 a bond Q3a OH
2962 N NEt QIl a bond Me a bond NH 0 a bond Q3d OH
2963 ' N NEt QIl a bond Me a bond NH 0 a bond Q3e OH
2964 N NEt QIl a bond Me a bond NH 0 a bond Q3f OH
2965 N NEt QIl a bond Me a bond NH 0 NH Q3a OH
2966 N NEt QIl a bond Me a bond NH 0 NH Q3d OH
2967 N NEt QIl a bond Me a bond NH 0 NH Q3e OH
2968 N NEt QIl a bond Me a bond NH 0 NH Q3f OH
2969 N NEt QIl a bond Me a bond NH S a bond Q3a OH
2970 N NEt QIl a bond Me a bond NH S a bond Q3d OH
2971 N NEt QIl a bond Me a bond NH S a bond Q3e OH
2972 N NEt QIl a bond Me a bond NH S a bond Q3f OH
2973 N NEt QIl a bond Me a bond NH S NH Q3a OH
2974 N NEt QIl a bond Me a bond NH S NH Q3d OH
2975 N NEt QIl a bond Me a bond NH S NH Q3e OH
2976 N NEt QIl a bond Me a bond NH S NH Q3f OH
2977 N NEt QIm a bond Me a bond NH 0 a bond Q3a OH
2978 N NEt QIm a bond Me a bond NH 0 a bond Q3d OH
2979 N NEt QIm a bond Me a bond NH 0 a bond Q3e OH
2980 N NEt QIm a bond Me a bond NH 0 a bond Q3f OH
2981 N NEt QIm a bond Me a bond NH 0 NH Q3a OH
2982 N NEt QIm a bond Me a bond NH 0 NH Q3d OH
2983 N NEt QIm a bond Me a bond NH 0 NH Q3e OH
2984 N NEt QIm a bond Me a bond NH 0 NH Q3f OH
2985 N NEt QIm a bond Me a bond NH S a bond Q3a OH
2986 N NEt QIm a bond Me a bond NH S a bond Q3d OH
2987 N NEt QIm a bond Me a bond NH S a bond Q3e OH
2988 N NEt QIm a bond Me a bond NH S a bond Q3f OH
2989 N NEt QIm a bond Me aa bboonndd N NHH S S N NHH Q Q33aa O OHH
2990 N NEt QIm a bond Me aa bboonndd N NHH S S N NHH Q Q33dd O OHH
2991 N NEt QIm a bond Me aa bboonndd N NHH S S N NHH Q Q33ee O OHH
2992 N NEt QIm a bond Me aa bboonndd N NHH S S N NHH Q Q33ff O OHH
2993 N NEt QIn a bond Me aa bboonndd N NHH 0 0 aa bboonndd Q Q33aa O OHH
2994 N NEt QIn a bond Me aa bboonndd N NHH 0 0 aa bboonndd Q Q33dd O OHH 2995 N NEt QIn a bond Me a bond NH 0 a bond Q3e OH
2996 N NEt QIn a bond Me a bond NH 0 a bond Q3f OH
2997 N NEt QIn a bond Me a bond NH 0 NH Q3a OH
2998 N NEt QIn a bond Me a bond NH 0 NH Q3d OH 2999 N NEt QIn a bond Me a bond NH 0 NH Q3e OH
3000 N NEt QIn a bond Me a bond NH 0 NH Q3f OH
3001 N NEt QIn a bond Me a bond NH S a bond Q3a OH
3002 N NEt QIn a bond Me a bond NH S a bond Q3d OH
3003 N NEt QIn a bond Me a bond NH S a bond Q3e OH 3004 N NEt QIn a bond Me a bond NH S a bond Q3f OH
3005 N NEt QIn a bond Me a bond NH S NH Q3a OH
3006 N NEt QIn a bond Me a bond NH S NH Q3d OH
3007 N NEt QIn a bond Me a bond NH S NH Q3e OH
3008 N NEt QIn a bond Me a bond NH S NH Q3f OH 3009 N S QIk a bond Me a bond NH 0 a bond Q3a OH
3010 N S QIk a bond Me a bond NH 0 a bond Q3d OH
3011 N S QIk a bond Me a bond NH 0 a bond Q3e OH
3012 N S QIk a bond Me a bond NH 0 a bond Q3f OH
3013 N S QIk a bond Me a bond NH 0 NH Q3a OH 3014 N S QIk a bond Me a bond NH 0 NH Q3d OH
3015 N S QIk a bond Me a bond NH 0 NH Q3e OH
3016 N S QIk a bond Me a bond NH 0 NH Q3f OH
3017 N S QIk a bond Me a bond NH S a bond Q3a OH
3018 N S QIk a bond Me a bond NH S a bond Q3d OH 3019 N S QIk a bond Me a bond NH S a bond Q3e OH
3020 N S QIk a bond Me a bond NH S a bond Q3f OH
3021 N S QIk a bond Me a bond NH S NH Q3a OH
3022 N S QIk a bond Me a bond NH S NH Q3d OH
3023 N S QIk a bond Me a bond NH S NH Q3e OH 3024 N S QIk a bond Me a bond NH S NH Q3f OH
3025 N S QIl a bond Me a bond NH 0 a bond Q3a OH
3026 N S QIl a bond Me a bond NH 0 a bond Q3d OH
3027 N S QIl a bond Me a bond NH 0 a bond Q3e OH
3028 N S QIl a bond Me a bond NH 0 a bond Q3f OH 3029 N S QIl a bond Me a bond NH 0 NH Q3a OH
3030 N S QIl a bond Me a bond NH 0 NH Q3d OH 3031 N S QIl a bond Me a bond NH 0 NH Q3e OH
3032 N S QIl a bond Me a bond NH 0 NH Q3f OH
3033 N S QIl a bond Me a bond NH S a bond Q3a OH
3034 N S QIl a bond Me a bond NH S a bond Q3d OH
3035 ' N S QIl a bond Me a bond NH S a bond Q3e OH
3036 N S QIl a bond Me a bond NH S a bond Q3f OH
3037 N S QIl a bond Me a bond NH S NH Q3a OH
3038 N S QIl a bond Me a bond NH S NH Q3d OH
3039 N S QIl a bond Me a bond NH S NH Q3e OH
3040 N S QIl a bond Me a bond NH S NH Q3f OH
3041 N S QIm a bond Me a bond NH 0 a bond Q3a OH
3042 N S QIm a bond Me a bond NH 0 a bond Q3d OH
3043 N S QIm a bond Me a bond NH 0 a bond Q3e OH
3044 N S QIm a bond Me a bond NH 0 a bond Q3f OH
3045 N S QIm a bond Me a bond NH 0 NH Q3a OH
3046 N S QIm a bond Me a bond NH 0 NH Q3d OH
3047 N S QIm a bond Me a bond NH 0 NH Q3e OH
3048 N S QIm a bond Me a bond NH 0 NH Q3f OH
3049 N S QIm a bond Me a bond NH S a bond Q3a OH
3050 N S QIm a bond Me a bond NH S a bond Q3d OH
3051 N S QIm a bond Me a bond NH S a bond Q3e OH
3052 N S QIm a bond Me a bond NH S a bond Q3f OH
3053 N S QIm a bond Me a bond NH S NH Q3a OH
3054 N S QIm a bond Me a bond NH S NH Q3d OH
3055 N S QIm a bond Me a bond NH S NH Q3e OH
3056 N S QIm a bond Me a bond NH S NH Q3f OH
3057 N S QIn a bond Me a bond NH 0 a bond Q3a OH
3058 N S QIn a bond Me a bond NH 0 a bond Q3d OH
3059 N S QIn a bond Me a bond NH 0 a bond Q3e OH
3060 N S QIn a bond Me a bond NH 0 a bond Q3f OH
3061 N S QIn a bond Me a bond NH 0 NH Q3a OH
3062 N S QIn a bond Me a bond NH 0 NH Q3d OH
3063 N S QIn a bond Me a bond NH 0 NH Q3e OH
3064 N S QIn a bond Me a bond NH 0 NH Q3f OH
3065 N S QIn a bond Me a bond NH S a bond Q3a OH
3066 N S QIn a bond Me a bond NH S a bond Q3d OH 3067 N S QIn a bond Me a bond NH S a bond Q3e OH
3068 N S QIn a bond Me a bond NH S a bond Q3f OH
3069 N S QIn a bond Me a bond NH S NH Q3a OH
3070 N S QIn a bond Me a bond NH S NH Q3d OH
3071 N S QIn a bond Me a bond NH S NH Q3e OH
3072 N S QIn a bond Me a bond NH S NH Q3f OH
3073 N 0 QIk a bond Me a bond NH 0 a bond Q3a OH
3074 N 0 QIk a bond Me a bond NH 0 a bond Q3d OH
3075 N 0 QIk a bond Me a bond NH 0 a bond Q3e OH
3076 N 0 QIk a bond Me a bond NH 0 a bond Q3f OH
3077 N 0 QIk a bond Me a bond NH 0 NH Q3a OH
3078 N 0 QIk a bond Me a bond NH 0 NH Q3d OH
3079 N 0 QIk a bond Me a bond NH 0 NH Q3e OH
3080 N O QIk a bond Me a bond NH 0 NH Q3f OH
3081 N O QIk a bond Me a bond NH S a bond Q3a OH
3082 N O QIk a bond Me a bond NH S a bond Q3d OH
3083 N O QIk a bond Me a bond NH S a bond Q3e OH
3084 N 0 QIk a bond Me a bond NH S a bond Q3f OH
3085 N O QIk a bond Me a bond NH S NH Q3a OH
3086 N 0 QIk a bond Me a bond NH S NH Q3d OH
3087 N O QIk a bond Me a bond NH S NH Q3e OH
3088 N 0 QIk a bond Me a bond NH S NH Q3f OH
3089 N 0 QIl a bond Me a bond NH 0 a bond Q3a OH
3090 N O QIl a bond Me a bond NH 0 a bond Q3d OH
3091 N O QIl a bond Me a bond NH 0 a bond Q3e OH
3092 N O QIl a bond Me a bond NH 0 a bond Q3f OH
3093 N O QIl a bond Me a bond NH 0 NH Q3a OH
3094 N O QIl a bond Me a bond NH 0 NH Q3d OH
3095 N 0 QIl a bond Me a bond NH 0 NH Q3e OH
3096 N O QIl a bond Me a bond NH 0 NH Q3f OH
3097 N 0 QIl a bond Me a bond NH S a bond Q3a OH
3098 N 0 QIl a bond Me a bond NH S a bond Q3d OH
3099 N 0 QIl a bond Me a bond NH S a bond Q3e OH
3100 N O QIl a bond Me a bond NH S a bond Q3f OH
3101 N 0 QIl a bond Me a bond NH S NH Q3a OH
3102 N 0 QIl a bond Me a bond NH S NH Q3d OH 3103 N 0 QIl a bond Me a bond NH S NH Q3e OH
3104 N 0 QIl a bond Me a bond NH S NH Q3f OH
3105 N 0 QIm a bond Me a bond NH 0 a bond Q3a OH
3106 N 0 QIm a bond Me a bond NH 0 a bond Q3d OH 3107 N 0 QIm a bond Me a bond NH 0 a bond Q3e OH
3108 N 0 QIm a bond Me a bond NH 0 a bond Q3f OH
3109 N 0 QIm a bond Me a bond NH 0 NH Q3a OH
3110 N 0 QIm a bond Me a bond NH 0 NH Q3d OH
3111 N 0 QIm a bond Me a bond NH 0 NH Q3e OH 3112 N 0 QIm a bond Me a bond NH 0 NH Q3f OH
3113 N 0 QIm a bond Me a bond NH S a bond Q3a OH
3114 N 0 QIm a bond Me a bond NH S a bond Q3d OH
3115 N 0 QIm a bond Me a bond NH S a bond Q3e OH
3116 N 0 QIm a bond Me a bond NH S a bond Q3f OH 3117 N 0 QIm a bond Me a bond NH S NH Q3a OH
3118 N 0 QIm a bond Me a bond NH S NH Q3d OH
3119 N 0 QIm a bond Me a bond NH S NH Q3e OH
3120 N 0 QIm a bond Me a bond NH S NH Q3f OH
3121 N 0 QIn a bond Me a bond NH 0 a bond Q3a OH 3122 N 0 QIn a bond Me a bond NH 0 a bond Q3d OH
3123 N 0 QIn a bond Me a bond NH 0 a bond Q3e OH
3124 N 0 QIn a bond Me a bond NH 0 a bond Q3f OH
3125 N 0 QIn a bond Me a bond NH 0 NH Q3a OH
3126 N 0 QIn a bond Me a bond NH 0 NH Q3d OH 3127 N 0 QIn a bond Me a bond NH 0 NH Q3e OH
3128 N 0 QIn a bond Me a bond NH 0 NH Q3f OH
3129 N 0 QIn a bond Me a bond NH S a bond Q3a OH
3130 N 0 QIn a bond Me a bond NH S a bond Q3d OH
3131 N 0 QIn a bond Me a bond NH S a bond Q3e OH 3132 N 0 QIn a bond Me a bond NH S a bond Q3f OH
3133 N 0 QIn a bond Me a bond NH S NH Q3a OH
3134 N 0 QIn a bond Me a bond NH S NH Q3d OH
3135 N 0 QIn a bond Me a bond NH S NH Q3e OH
3136 N 0 QIn a bond Me a bond NH S NH Q3f OH 3137 CH NMe QIk a bond Me a bond NH 0 a bond Q3a OH
3138 CH NMe QIk a bond Me a bond NH 0 a bond Q3d OH 3139 CH NMe QIk a bond Me a bond NH 0 a bond Q3e OH
3140 CH NMe QIk a bond Me a bond NH 0 a bond Q3f OH
3141 CH NMe QIk a bond Me a bond NH 0 NH Q3a OH
3142 CH NMe QIk a bond Me a bond NH 0 NH Q3d OH 3143 CH NMe QIk a bond Me a bond NH 0 NH Q3e OH
3144 CH NMe QIk a bond Me a bond NH 0 NH Q3f OH
3145 CH NMe QIk a bond Me a bond NH S a bond Q3a OH
3146 CH NMe QIk a bond Me a bond NH S a bond Q3d OH
3147 CH NMe QIk a bond Me a bond NH S a bond Q3e OH 3148 CH NMe QIk a bond Me a bond NH S a bond Q3f OH
3149 CH NMe QIk a bond Me a bond NH S NH Q3a OH
3150 CH NMe QIk a bond Me a bond NH S NH Q3d OH
3151 CH NMe QIk a bond Me a bond NH S NH Q3e OH
3152 CH NMe QIk a bond Me a bond NH S NH Q3f OH 3153 CH NMe QIl a bond Me a bond NH 0 a bond Q3a OH
3154 CH NMe QIl a bond Me a bond NH 0 a bond Q3d OH
3155 CH NMe QIl a bond Me a bond NH 0 a bond Q3e OH
3156 CH NMe QIl a bond Me a bond NH 0 a bond Q3f OH
3157 CH NMe QIl a bond Me a bond NH 0 NH Q3a OH 3158 CH NMe QIl a bond Me a bond NH 0 NH Q3d OH
3159 CH NMe QIl a bond Me a bond NH 0 NH Q3e OH
3160 CH NMe QIl a bond Me a bond NH 0 NH Q3f OH
3161 CH NMe QIl a bond Me a bond NH S a bond Q3a OH
3162 CH NMe QIl a bond Me a bond NH S a bond Q3d OH 3163 CH NMe QIl a bond Me a bond NH S a bond Q3e OH
3164 CH NMe QIl a bond Me a bond NH S a bond Q3f OH
3165 CH NMe QIl a bond Me a bond NH S NH Q3a OH
3166 CH NMe QIl a bond Me a bond NH S NH Q3d OH
3167 CH NMe QIl a bond Me a bond NH S NH Q3e OH 3168 CH NMe QIl a bond Me a bond NH S NH Q3f OH
3169 CH NMe QIm a bond Me a bond NH 0 a bond Q3a OH
3170 CH NMe QIm a bond Me a bond NH 0 a bond Q3d OH
3171 CH NMe QIm a bond Me a bond NH 0 a bond Q3e OH
3172 CH NMe QIm a bond Me a bond NH 0 a bond Q3f OH 3173 CH NMe QIm a bond Me a bond NH 0 NH Q3a OH
3174 CH NMe QIm a bond Me a bond NH 0 NH Q3d OH 3175 CH NMe QIm a bond Me a bond NH 0 NH Q3e OH
3176 CH NMe QIm a bond Me a bond NH 0 NH Q3f OH
3177 CH NMe QIm a bond Me a bond NH S a bond Q3a OH
3178 CH NMe QIm a bond Me a bond NH S a bond Q3d OH
3179 CH NMe QIm a bond Me a bond NH S a bond Q3e OH
3180 CH NMe QIm a bond Me a bond NH S a bond Q3f OH
3181 CH NMe QIm a bond Me a bond NH S NH Q3a OH
3182 CH NMe QIm a bond Me a bond NH S NH Q3d OH
3183 CH NMe QIm a bond Me a bond NH S NH Q3e OH
3184 CH NMe QIm a bond Me a bond NH S NH Q3f OH
3185 CH NMe QIn a bond Me a bond NH 0 a bond Q3a OH
3186 CH NMe QIn a bond Me a bond NH 0 a bond Q3d OH
3187 CH NMe QIn a bond Me a bond NH 0 a bond Q3e OH
3188 CH NMe QIn a bond Me a bond NH 0 a bond Q3f OH
3189 CH NMe QIn a bond Me a bond NH 0 NH Q3a OH
3190 CH NMe QIn a bond Me a bond NH 0 NH Q3d OH
3191 CH NMe QIn a bond Me a bond NH 0 NH Q3e OH
3192 CH NMe QIn a bond Me a bond NH 0 NH Q3f OH
3193 CH NMe QIn a bond Me a bond NH S a bond Q3a OH
3194 CH NMe QIn a bond Me a bond NH S a bond Q3d OH
3195 CH NMe QIn a bond Me a bond NH S a bond Q3e OH
3196 CH NMe QIn a bond Me a bond NH S a bond Q3f OH
3197 CH NMe QIn a bond Me a bond NH S NH Q3a OH
3198 CH NMe QIn a bond Me a bond NH S NH Q3d OH
3199 CH NMe QIn a bond Me a bond NH S NH Q3e OH
3200 CH NMe QIn a bond Me a bond NH S NH Q3f OH
3201 CH NEt QIk a bond Me a bond NH 0 a bond Q3a OH
3202 CH NEt QIk a bond Me a bond NH 0 a bond Q3d OH
3203 CH NEt QIk a bond Me a bond NH 0 a bond Q3e OH
3204 CH NEt QIk a bond Me a bond NH 0 a bond Q3f OH
3205 CH NEt QIk a bond Me a bond NH 0 NH Q3a OH
3206 CH NEt QIk a bond Me a bond NH 0 NH Q3d OH
3207 CH NEt QIk a bond Me a bond NH 0 NH Q3e OH
3208 CH NEt QIk a bond Me a bond NH 0 NH Q3f OH
3209 CH NEt QIk a bond Me a bond NH S a bond Q3a OH
3210 CH NEt QIk a bond Me a bond NH S a bond Q3d OH 3211 CH NEt QIk a bond Me a bond NH S a bond Q3e OH
3212 CH NEt QIk a bond Me a bond NH S a bond Q3f OH
3213 CH NEt QIk a bond Me a bond NH S NH Q3a OH
3214 CH NEt QIk a bond Me a bond NH S NH Q3d OH
3215 CH NEt QIk a bond Me a bond NH S NH Q3e OH
3216 CH NEt QIk a bond Me a bond NH S NH Q3f OH
3217 CH NEt QIl a bond Me a bond NH 0 a bond Q3a OH
3218 CH NEt QIl a bond Me a bond NH 0 a bond Q3d OH
3219 CH NEt QIl a bond Me a bond NH 0 a bond Q3e OH
3220 CH NEt QIl a bond Me a bond NH 0 a bond Q3f OH
3221 CH NEt QIl a bond Me a bond NH 0 NH Q3a OH
3222 CH NEt QIl a bond Me a bond NH 0 NH Q3d OH
3223 CH NEt QIl a bond Me a bond NH 0 NH Q3e OH
3224 CH NEt QIl a bond Me a bond NH 0 NH Q3f OH
3225 CH NEt QIl a bond Me a bond NH S a bond Q3a OH
3226 CH NEt QIl a bond Me a bond NH S a bond Q3d OH
3227 CH NEt QIl a bond Me a bond NH S a bond Q3e OH
3228 CH NEt QIl a bond Me a bond NH S a bond Q3f OH
3229 CH NEt QIl a bond Me a bond NH S NH Q3a OH
3230 CH NEt QIl a bond Me a bond NH S NH Q3d OH
3231 CH NEt QIl a bond Me a bond NH S NH Q3e OH
3232 CH NEt QIl a bond Me a bond NH S NH Q3f OH
3233 CH NEt QIm a bond Me a bond NH 0 a bond Q3a OH
3234 CH NEt QIm a bond Me a bond NH 0 a bond Q3d OH
3235 CH NEt QIm a bond Me a bond NH 0 a bond Q3e OH
3236 CH NEt QIm a bond Me a bond NH 0 a bond Q3f OH
3237 CH NEt QIm a bond Me a bond NH 0 NH Q3a OH
3238 CH NEt QIm a bond Me a bond NH 0 NH Q3d OH
3239 CH NEt QIm a bond Me a bond NH 0 NH Q3e OH
3240 CH NEt QIm a bond Me a bond NH 0 NH Q3f OH
3241 CH NEt QIm a bond Me a bond NH S a bond Q3a OH
3242 CH NEt QIm a bond Me a bond NH S a bond Q3d OH
3243' CH NEt QIm a bond Me a bond NH S a bond Q3e OH
3244 CH NEt QIm a bond Me a bond NH S a bond Q3f OH
3245 CH NEt QIm a bond Me a bond NH S NH Q3a OH
3246 CH NEt QIm a bond Me a bond NH S NH Q3d OH 3247 CH NEt QIm a bond Me a bond NH S NH Q3e OH
3248 CH NEt QIm a bond Me a bond NH S NH Q3f OH
3249 CH NEt QIn a bond Me a bond NH 0 a bond Q3a OH
3250 CH NEt QIn a bond Me a bond NH 0 a bond Q3d OH
3251 CH NEt QIn a bond Me a bond NH 0 a bond Q3e OH
3252 CH NEt QIn a bond Me a bond NH 0 a bond Q3f OH
3253 CH NEt QIn a bond Me a bond NH 0 NH Q3a OH
3254 CH NEt QIn a bond Me a bond NH 0 NH Q3d OH
3255 CH NEt QIn a bond Me a bond NH 0 NH Q3e OH
3256 CH NEt QIn a bond Me a bond NH 0 NH Q3f OH
3257 CH NEt QIn a bond Me a bond NH S a bond Q3a OH
3258 CH NEt QIn a bond Me a bond NH S a bond Q3d OH
3259 CH NEt QIn a bond Me a bond NH S a bond Q3e OH
3260 CH NEt QIn a bond Me a bond NH S a bond Q3f OH
3261 CH NEt QIn a bond Me a bond NH S NH Q3a OH
3262 CH NEt QIn a bond Me a bond NH S NH Q3d OH
3263 CH NEt QIn a bond Me a bond NH S NH Q3e OH
3264 CH NEt QIn a bond Me a bond NH S NH Q3f OH
3265 CH S QIk a bond Me a bond NH 0 a bond Q3a OH
3266 CH S QIk a bond Me a bond NH 0 a bond Q3d OH
3267 CH S QIk a bond Me a bond NH 0 a bond Q3e OH
3268 CH S QIk a bond Me a bond NH 0 a bond Q3f OH
3269 CH S QIk a bond Me a bond NH 0 NH Q3a OH
3270 CH S QIk a bond Me a bond NH 0 NH Q3d OH
3271 CH S QIk a bond Me a bond NH 0 NH Q3e OH
3272 CH S QIk a bond Me a bond NH 0 NH Q3f OH
3273 CH S QIk a bond Me a bond NH S a bond Q3a OH
3274 CH S QIk a bond Me a bond NH S a bond Q3d OH
3275 CH S QIk a bond Me a bond NH S a bond Q3e OH
3276 CH S QIk a bond Me a bond NH S a bond Q3f OH
3277 CH S QIk a bond Me a bond NH S NH Q3a OH
3278 CH S QIk a bond Me a bond NH S NH Q3d OH
3279 CH S QIk a bond Me a bond NH S NH Q3e OH
3280 CH S QIk a bond Me a bond NH S NH Q3f OH
3281 CH S QIl a bond Me a bond NH 0 a bond Q3a OH
3282 CH S QIl a bond Me a bond NH 0 a bond Q3d OH 3283 CH S QIl a bond Me a bond NH 0 a bond Q3e OH
3284 CH S QIl a bond Me a bond NH 0 a bond Q3f OH
3285 CH S QIl a bond Me a bond NH 0 NH Q3a OH
3286 CH S QIl a bond Me a bond NH 0 NH Q3d OH
3287 CH S QIl a bond Me a bond NH 0 NH Q3e OH
3288 CH S QIl a bond Me a bond NH 0 NH Q3f OH
3289 CH S QIl a bond Me a bond NH S a bond Q3a OH
3290 CH S QIl a bond Me a bond NH S a bond Q3d OH
3291 CH S QIl a bond Me a bond NH S a bond Q3e OH
3292 CH S QIl a bond Me a bond NH S a bond Q3f OH
3293 CH S QIl a bond Me a bond NH S NH Q3a OH
3294 CH S QIl a bond Me a bond NH S NH Q3d OH
3295 CH S QIl a bond Me a bond NH S NH Q3e OH
3296 CH S QIl a bond Me a bond NH S NH Q3f OH
3297 CH S QIm a bond Me a bond NH 0 a bond Q3a OH
3298 CH S QIm a bond Me a bond NH 0 a bond Q3d OH
3299 CH S QIm a bond Me a bond NH 0 a bond Q3e OH
3300 CH S QIm a bond Me a bond NH 0 a bond Q3f OH
3301 CH S QIm a bond Me a bond NH 0 NH Q3a OH
3302 CH S QIm a bond Me a bond NH 0 NH Q3d OH
3303 CH S QIm a bond Me a bond NH 0 NH Q3e OH
3304 CH S QIm a bond Me a bond NH 0 NH Q3f OH
3305 CH S QIm a bond Me a bond NH S a bond Q3a OH
3306 CH S QIm a bond Me a bond NH S a bond Q3d OH
3307 CH S QIm a bond Me a bond NH S a bond Q3e OH
3308 CH S QIm a bond Me a bond NH S a bond Q3f OH
3309 CH S QIm a bond Me a bond NH S NH Q3a OH
3310 CH S QIm a bond Me a bond NH S NH Q3d OH
3311 CH S QIm a bond Me a bond NH S NH Q3e OH
3312 CH S QIm a bond Me a bond NH S NH Q3f OH
3313 CH S QIn a bond Me a bond NH 0 a bond Q3a OH
3314 CH S QIn a bond Me a bond NH 0 a bond Q3d OH
3315 CH S QIn a bond Me a bond NH 0 a bond Q3e OH
3316 CH S QIn a bond Me a bond NH 0 a bond Q3f OH
3317 CH S QIn a bond Me a bond NH 0 NH Q3a OH
3318 CH S QIn a bond Me a bond NH 0 NH Q3d OH 3319 CH S QIn a bond Me a bond NH 0 NH Q3e OH
3320 CH S QIn a bond Me a bond NH 0 NH Q3f OH
3321 CH S QIn a bond Me a bond NH S a bond Q3a OH
3322 CH S QIn a bond Me a bond NH S a bond Q3d OH
3323 CH S QIn a bond Me a bond NH S a bond Q3e OH
3324 CH S QIn a bond Me a bond NH S a bond Q3f OH
3325 CH S QIn a bond Me a bond NH S NH Q3a OH
3326 CH S QIn a bond Me a bond NH S NH Q3d OH
3327 CH S QIn a bond Me a bond NH S NH Q3e OH
3328 CH S QIn a bond Me a bond NH S NH Q3f OH
3329 CH 0 QIk a bond Me a bond NH 0 a bond Q3a OH
3330 CH 0 QIk a bond Me a bond NH 0 a bond Q3d OH
3331 CH 0 QIk a bond Me a bond NH 0 a bond Q3e OH
3332 CH 0 QIk a bond Me a bond NH 0 a bond Q3f OH
3333 CH 0 QIk a bond Me a bond NH 0 NH Q3a OH
3334 CH 0 QIk a bond Me a bond NH 0 NH Q3d OH
3335 CH 0 QIk a bond Me a bond NH 0 NH Q3e OH
3336 CH 0 QIk a bond Me a bond NH 0 NH Q3f OH
3337 CH 0 QIk a bond Me a bond NH S a bond Q3a OH
3338 CH 0 QIk a bond Me a bond NH S a bond Q3d OH
3339 CH 0 QIk a bond Me a bond NH S a bond Q3e OH
3340 CH 0 QIk a bond Me a bond NH S a bond Q3f OH
3341 CH 0 QIk a bond Me a bond NH S NH Q3a OH
3342 CH 0 QIk a bond Me a bond NH S NH Q3d OH
3343 CH 0 QIk a bond Me a bond NH S NH Q3e OH
3344 CH 0 QIk a bond Me a bond NH NH Q3f OH
3345 CH 0 QIl a bond Me a bond NH 0 a bond Q3a OH
3346 CH 0 QIl a bond Me a bond NH 0 a bond Q3d OH
3347 CH 0 QIl a bond Me a bond NH 0 a bond Q3e OH
3348 CH 0 QIl a bond Me a bond NH 0 a bond Q3f OH
3349 CH 0 QIl a bond Me a bond NH 0 NH Q3a OH
3350 CH 0 QIl a bond Me a bond NH 0 NH Q3d OH
3351 CH 0 QIl a bond Me a bond NH 0 NH Q3e OH
3352 CH 0 QIl a bond Me a bond NH 0 NH Q3f OH
3353 CH 0 QIl a bond Me a bond NH S a bond Q3a OH
3354 CH 0 QIl a bond Me a bond NH S a bond Q3d OH 3355 CH 0 QIl a bond Me a bond NH S a bond Q3e OH
3356 CH 0 QIl a bond Me a bond NH S a bond Q3f OH
3357 CH 0 QIl a bond Me a bond NH S NH Q3a OH
3358 CH 0 QIl a bond Me a bond NH S NH Q3d OH
3359 CH 0 QIl a bond Me a bond NH S NH Q3e OH
3360 CH 0 QIl a bond Me a bond NH S NH Q3f OH
3361 CH 0 QIm a bond Me a bond NH 0 a bond Q3a OH
3362 CH 0 QIm a bond Me a bond NH 0 a bond Q3d OH
3363 CH 0 QIm a bond Me a bond NH 0 a bond Q3e OH
3364 CH 0 QIm a bond Me a bond NH 0 a bond Q3f OH
3365 CH 0 QIm a bond Me a bond NH 0 NH Q3a OH
3366 CH 0 QIm a bond Me a bond NH 0 NH Q3d OH
3367 CH 0 QIm a bond Me a bond NH 0 NH Q3e OH
3368 CH 0 QIm a bond Me a bond NH 0 NH Q3f OH
3369 CH 0 QIm a bond Me a bond NH S a bond Q3a OH
3370 CH 0 QIm a bond Me a bond NH S a bond Q3d OH
3371 CH 0 QIm a bond Me a bond NH S a bond Q3e OH
3372 CH 0 QIm a bond Me a bond NH S a bond Q3f OH
3373 CH 0 QIm a bond Me a bond NH S NH Q3a OH
3374 CH 0 QIm a bond Me a bond NH S NH Q3d OH
3375 CH 0 QIm a bond Me a bond NH S NH Q3e OH
3376 CH 0 QIm a bond Me a bond NH S NH Q3f OH
3377 CH 0 QIn a bond Me a bond NH 0 a bond Q3a OH
3378 CH 0 QIn a bond Me a bond NH 0 a bond Q3d OH
3379 CH 0 QIn a bond Me a bond NH 0 a bond Q3e OH
3380 CH 0 QIn a bond Me a bond NH 0 a bond Q3f OH
3381 CH 0 QIn a bond Me a bond NH 0 NH Q3a OH
3382 CH 0 QIn a bond Me a bond NH 0 NH Q3d OH
3383 CH 0 QIn a bond Me a bond NH 0 NH Q3e OH
3384 CH 0 QIn a bond Me a bond NH 0 NH Q3f OH
3385 CH 0 QIn a bond Me a bond NH S a bond Q3a OH
3386 CH 0 QIn a bond Me a bond NH S a bond Q3d OH
3387 CH 0 QIn a bond Me a bond NH S a bond Q3e OH
3388 CH 0 QIn a bond Me a bond NH S a bond Q3f OH
3389 CH 0 QIn a bond Me a bond NH S NH Q3a OH
3390 CH 0 QIn a bond Me a bond NH S NH Q3d OH 3391 CH 0 QIn a bond Me a bond NH S NH Q3e OH
3392 CH 0 QIn a bond Me a bond NH S NH Q3f OH
3393 CMe NMe QIk a bond Me a bond NH 0 a bond Q3a OH
3394 CMe NMe QIk a bond Me a bond NH 0 a bond Q3d OH 3395 ' CMe NMe QIk a bond Me a bond NH 0 a bond Q3e OH
3396 CMe NMe QIk a bond Me a bond NH 0 a bond Q3f OH
3397 CMe NMe QIk a bond Me a bond NH 0 NH Q3a OH
3398 CMe NMe QIk a bond Me a bond NH 0 NH Q3d OH
3399 CMe NMe QIk a bond Me a bond NH 0 NH Q3e OH 3400 CMe NMe QIk a bond Me a bond NH 0 NH Q3f OH
3401 CMe NMe QIk a bond Me a bond NH S a bond Q3a OH
3402 CMe NMe QIk a bond Me a bond NH S a bond Q3d OH
3403 CMe NMe QIk a bond Me a bond NH S a bond Q3e OH
3404 CMe NMe QIk a bond Me a bond NH S a bond Q3f OH 3405 CMe NMe QIk a bond Me a bond NH S NH Q3a OH
3406 CMe NMe QIk a bond Me a bond NH S NH Q3d OH
3407 CMe NMe QIk a bond Me a bond NH S NH Q3e OH
3408 CMe NMe QIk a bond Me a bond NH S NH Q3f OH
3409 CMe NMe QIl a bond Me a bond NH O a bond Q3a OH 3410 CMe NMe QIl a bond Me a bond NH O a bond Q3d OH
3411 CMe NMe QIl a bond Me a bond NH O a bond Q3e OH
3412 CMe NMe QIl a bond Me a bond NH O a bond Q3f OH
3413 CMe NMe QIl a bond Me a bond NH 0 NH Q3a OH
3414 CMe NMe QIl a bond Me a bond NH 0 NH Q3d OH 3415 CMe NMe QIl a bond Me a bond NH 0 NH Q3e OH
3416 CMe NMe QIl a bond Me a bond NH 0 NH Q3f OH
3417 CMe NMe QIl a bond Me a bond NH S a bond Q3a OH
3418 CMe NMe QIl a bond Me a bond NH S a bond Q3d OH
3419 CMe NMe QIl a bond Me a bond NH S a bond Q3e OH 3420 CMe NMe QIl a bond Me a bond NH S a bond Q3f OH
3421 CMe NMe QIl a bond Me a bond NH S NH Q3a OH
3422 CMe NMe QIl a bond Me a bond NH S NH Q3d OH
3423 CMe NMe QIl a bond Me a bond NH S NH Q3e OH
3424 CMe NMe QIl a bond Me a bond NH S NH Q3f OH 3425 CMe NMe QIm a bond Me a bond NH O a bond Q3a OH
3426 CMe NMe QIm a bond Me a bond NH 0 a. bond Q3d OH 3427 CMe NMe QIm a bond Me a bond NH O a bond Q3e OH
3428 CMe NMe QIm a bond Me a bond NH O a bond Q3f OH
3429 CMe NMe QIm a bond Me a bond NH 0 NH Q3a OH
3430 CMe NMe QIm a bond Me a bond NH 0 NH Q3d OH 3431 CMe NMe QIm a bond Me a bond NH 0 NH Q3e OH
3432 CMe NMe QIm a bond Me a bond NH 0 NH Q3f OH
3433 CMe NMe QIm a bond Me a bond NH S a bond Q3a OH
3434 CMe NMe QIm a bond Me a bond NH S a bond Q3d OH
3435 CMe NMe QIm a bond Me a bond NH S a bond Q3e OH 3436 CMe NMe QIm a bond Me a bond NH S a bond Q3f OH
3437 CMe NMe QIm a bond Me a bond NH S NH Q3a OH
3438 CMe NMe QIm a bond Me a bond NH S NH Q3d OH
3439 CMe NMe QIm a bond Me a bond NH S NH Q3e OH
3440 CMe NMe QIm a bond Me a bond NH S NH Q3f OH 3441 CMe NMe QIn a bond Me a bond NH O a bond Q3a OH
3442 CMe NMe QIn a bond Me a bond NH O a bond Q3d OH
3443 CMe NMe QIn a bond Me a bond NH O a bond Q3e OH
3444 CMe NMe QIn a bond Me a bond NH O a bond Q3f OH
3445 CMe NMe QIn a bond Me a bond NH 0 NH Q3a OH 3446 CMe NMe QIn a bond Me a bond NH 0 NH Q3d OH
3447 CMe NMe QIn a bond Me a bond NH 0 NH Q3e OH
3448 CMe NMe QIn a bond Me a bond NH 0 NH Q3f OH
3449 CMe NMe QIn a bond Me a bond NH S a bond Q3a OH
3450 CMe NMe QIn a bond Me a bond NH S a bond Q3d OH 3451 CMe NMe QIn a bond Me a bond NH S a bond Q3e OH
3452 CMe NMe QIn a bond Me a bond NH S a bond "Q3f OH
3453 CMe NMe QIn a bond Me a bond NH S NH Q3a OH
3454 CMe NMe QIn a bond Me a bond NH S NH Q3d OH
3455 CMe NMe QIn a bond Me a bond NH S NH Q3e OH 3456 CMe' NMe QIn a bond Me a bond NH S NH Q3f OH
3457 CMe NEt QIk a bond Me a bond NH O a bond Q3a OH
3458 CMe NEt QIk a bond Me a bond NH O a bond Q3d OH 3459' CMe NEt QIk a bond Me a bond NH O a bond Q3e OH 3460 CMe NEt QIk a bond Me a bond NH O a bond Q3f OH 3461 CMe NEt QIk a bond Me a bond NH 0 NH Q3a OH
3462 CMe NEt QIk a bond Me a bond NH 0 M Q3d OH 3463 CMe NEt QIk a bond Me a bond NH 0 NH Q3e OH
3464 CMe NEt QIk a bond Me a bond NH 0 NH Q3f OH
3465 CMe NEt QIk a bond Me a bond NH S a bond Q3a OH
3466 CMe NEt QIk a bond Me a bond NH S a bond Q3d OH 3467 CMe NEt QIk a bond Me a bond NH S a bond Q3e OH
3468 CMe NEt QIk a bond Me a bond NH S a bond Q3f OH
3469 CMe NEt QIk a bond Me a bond NH S NH Q3a OH
3470 CMe NEt QIk a bond Me a bond NH S NH Q3d OH
3471 CMe NEt QIk a bond Me a bond NH S NH Q3e OH 3472 CMe NEt QIk a bond Me a bond NH S NH Q3f OH
3473 CMe NEt QIl a bond Me a bond NH O a bond Q3a OH
3474 CMe NEt QIl a bond Me a bond NH O a bond Q3d OH
3475 CMe NEt QIl a bond Me a bond NH O a bond Q3e OH
3476 CMe NEt QIl a bond Me a bond NH O a bond Q3f OH 3477 CMe NEt QIl a bond Me a bond NH 0 NH Q3a OH
3478 CMe NEt QIl a bond Me a bond I 0 I 03d OH
3479 CMe NEt QIl a bond Me a bond NH 0 NH Q3e OH
3480 CMe NEt QIl a bond Me a bond NH 0 NH Q3f OH
3481 CMe NEt QIl a bond Me a bond NH S a bond Q3a OH 3482 CMe NEt QIl a bond Me a bond NH S a bond Q3d OH
3483 CMe NEt QIl a bond Me a bond NH S a bond Q3e OH
3484 CMe NEt QIl a bond Me a bond NH S a bond Q3f OH
3485 CMe NEt QIl a bond Me a bond NH S NH Q3a OH
3486 CMe NEt QIl a bond Me a bond NH S NH Q3d OH 3487 CMe NEt QIl a bond Me a bond NH S NH Q3e OH
3488 CMe NEt QIl a bond Me a bond NH S NH Q3f OH
3489 CMe NEt QIm a bond Me a bond NH O a bond Q3a OH
3490 CMe NEt QIm a bond Me a bond NH O a bond Q3d OH
3491 CMe NEt QIm a bond Me a bond NH O a bond Q3e OH 3492 CMe NEt QIm a bond Me a bond NH O a bond Q3f OH
3493 CMe NEt QIm a bond Me a bond NH 0 NH Q3a OH
3494 CMe NEt QIm a bond Me a bond NH 0 NH Q3d OH
3495 CMe NEt QIm a bond Me a bond NH 0 NH Q3e OH
3496 CMe NEt QIm a bond Me a bond NH 0 NH Q3f OH 3497 CMe NEt QIm a bond Me a bond NH S a bond Q3a OH
3498 CMe NEt QIm a bond Me a bond NH S a bond Q3d OH 3499 CMe NEt QIm a bond Me a bond NH S a bond Q3e OH
3500 CMe NEt QIm a bond Me a bond NH S a bond Q3f OH
3501 CMe NEt QIm a bond Me a bond NH S NH Q3a OH
3502 CMe NEt QIm a bond Me a bond NH S NH Q3d OH
3503' CMe NEt QIm a bond Me a bond NH S NH Q3e OH
3504 CMe NEt QIm a bond Me a bond NH S NH Q3f OH
3505 CMe NEt QIn a bond Me a bond NH 0 a bond Q3a OH
3506 CMe NEt QIn a bond Me a bond NH 0 a bond Q3d OH
3507 CMe NEt QIn a bond Me a bond NH 0 a bond Q3e OH
3508 CMe NEt QIn a bond Me a bond NH 0 a bond Q3f OH
3509 CMe NEt QIn a bond Me a bond NH 0 NH Q3a OH
3510 CMe NEt QIn a bond Me a bond NH 0 NH Q3d OH
3511 CMe NEt QIn a bond Me a bond NH 0 NH Q3e OH
3512 CMe NEt QIn a bond Me a bond NH 0 NH Q3f OH
3513 CMe NEt QIn a bond Me a bond NH S a bond Q3a OH
3514 CMe NEt QIn a bond Me a bond NH S a bond Q3d OH
3515 CMe NEt QIn a bond Me a bond NH S a bond Q3e OH
3516 CMe NEt QIn a bond Me a bond NH S a bond Q3f OH
3517 CMe NEt QIn a bond Me a bond NH S NH Q3a OH
3518 CMe NEt QIn a bond Me a bond NH S NH Q3d OH
3519 CMe NEt QIn a bond Me a bond NH S NH Q3e OH
3520 CMe NEt QIn a bond Me a bond NH S NH Q3f OH
3521 CMe S QIk a bond Me a bond NH 0 a bond Q3a OH
3522 CMe S QIk a bond Me a bond NH 0 a bond Q3d OH
3523 CMe S QIk a bond Me a bond NH 0 a bond Q3e OH
3524 CMe S QIk a bond Me a bond NH 0 a bond Q3f OH
3525 CMe S QIk a bond Me a bond NH 0 NH Q3a OH
3526 CMe S QIk a bond Me a bond NH 0 NH Q3d OH
3527 CMe S QIk a bond Me a bond NH 0 NH Q3e OH
3528 CMe S QIk a bond Me a bond NH 0 NH Q3f OH
3529 CMe S QIk a bond Me a bond NH S a bond Q3a OH
3530 CMe S QIk a bond Me a bond NH S a bond Q3d OH
3531' CMe S QIk a bond Me a bond NH S a bond Q3e OH
3532 CMe S QIk a bond Me a bond NH S a bond Q3f OH
3533 CMe S QIk a bond Me a bond NH S NH Q3a OH
3534 CMe S QIk a bond Me a bond NH S .NH Q3d OH 3535 CMe S QIk a bond Me a bond NH S NH Q3e OH
3536 CMe S QIk a bond Me a bond NH S NH Q3f OH
3537 CMe S QIl a bond Me a bond NH 0 a bond Q3a OH
3538 CMe S QIl a bond Me a bond NH 0 a bond Q3d OH
3539 CMe S QIl a bond Me a bond NH 0 a bond Q3e OH
3540 CMe S QIl a bond Me a bond NH 0 a bond Q3f OH
3541 CMe S QIl a bond Me a bond NH 0 NH Q3a OH
3542 CMe S QIl a bond Me a bond NH 0 NH Q3d OH
3543 CMe S QIl a bond Me a bond NH 0 NH Q3e OH
3544 CMe S QIl a bond Me a bond NH 0 NH Q3f OH
3545 CMe S QIl a bond Me a bond NH S a bond Q3a OH
3546 CMe S QIl a bond Me a bond NH S a bond Q3d OH
3547 CMe S QIl a bond Me a bond NH S a bond Q3e OH
3548 CMe S QIl a bond Me a bond NH S a bond Q3f OH
3549 CMe S QIl a bond Me a bond NH S NH Q3a OH
3550 CMe S QIl a bond Me a bond NH S NH Q3d OH
3551 CMe S QIl a bond Me a bond NH S NH Q3e OH
3552 CMe S QIl a bond Me a bond NH S NH Q3f OH
3553 CMe S QIm a bond Me a bond NH 0 a bond Q3a OH
3554 CMe S QIm a bond Me a bond NH 0 a bond Q3d OH
3555 CMe S QIm a bond Me a bond NH 0 a bond Q3e OH
3556 CMe S QIm a bond Me a bond NH 0 a bond Q3f OH
3557 CMe S QIm a bond Me a bond NH 0 NH Q3a OH
3558 CMe S QIm a bond Me a bond NH 0 NH Q3d OH
3559 CMe S QIm a bond Me a bond NH 0 NH Q3e OH
3560 CMe S QIm a bond Me a bond NH 0 NH Q3f OH
3561 CMe S QIm a bond Me a bond NH S a bond Q3a OH
3562 CMe S QIm a bond Me a bond NH S a bond Q3d OH
3563 CMe S QIm a bond Me a bond NH S a bond Q3e OH
3564 CMe S QIm a bond Me a bond NH S a bond Q3f OH
3565 CMe S QIm a bond Me a bond NH S NH Q3a OH
3566 CMe S QIm a bond Me a bond NH S NH Q3d OH
3567 CMe S QIm a bond Me a bond NH S NH Q3e OH
3568 CMe S QIm a bond Me a bond NH S NH Q3f OH
3569 CMe S QIn a bond Me a bond NH 0 a bond Q3a OH
3570 CMe S QIn a bond Me a bond NH 0 a . bond Q3d OH 3571 CMe S QIn a bond Me a bond NH 0 a bond Q3e OH
3572 CMe S QIn a bond Me a bond NH 0 a bond Q3f OH
3573 CMe S QIn a bond Me a bond NH 0 NH Q3a OH
3574 CMe S QIn a bond Me a bond NH 0 NH Q3d OH
3575' CMe S QIn a bond Me a bond NH 0 NH Q3e OH
3576 CMe S QIn a bond Me a bond NH 0 NH Q3f OH
3577 CMe S QIn a bond Me a bond NH S a bond Q3a OH
3578 CMe S QIn a bond Me a bond NH S a bond Q3d OH
3579 CMe S QIn a bond Me a bond NH S a bond Q3e OH
3580 CMe S QIn a bond Me a bond NH S a bond Q3f OH
3581 CMe S QIn a bond Me a bond NH S NH Q3a OH
3582 CMe S QIn a bond Me a bond NH S NH Q3d OH
3583 CMe S QIn a bond Me a bond NH S NH Q3e OH
3584 CMe S QIn a bond Me a bond NH S NH Q3f OH
3585 CMe 0 QIk a bond Me a bond NH 0 a bond Q3a OH
3586 CMe 0 QIk a bond Me a bond NH 0 a bond Q3d OH
3587 CMe 0 QIk a bond Me a bond NH 0 a bond Q3e OH
3588 CMe 0 QIk a bond Me a bond NH 0 a bond Q3f OH
3589 CMe 0 QIk a bond Me a bond NH 0 NH Q3a OH
3590 CMe 0 QIk a bond Me a bond NH 0 NH Q3d OH
3591 CMe 0 QIk a bond Me a bond NH 0 NH Q3e OH
3592 CMe 0 QIk a bond Me a bond NH 0 NH Q3f OH
3593 CMe 0 QIk a bond Me a bond NH S a bond Q3a OH
3594 CMe 0 QIk a bond Me a bond NH S a bond Q3d OH
3595 CMe 0 QIk a bond Me a bond NH S a bond Q3e OH
3596 CMe 0 QIk a bond Me a bond NH S a bond Q3f OH
3597 CMe 0 QIk a bond Me a bond NH S NH Q3a OH
3598 CMe 0 QIk a bond Me a bond NH S NH Q3d OH
3599 CMe 0 QIk a bond Me a bond NH S NH Q3e OH
3600 CMe 0 QIk a bond Me a bond NH S NH Q3f OH
3601 CMe 0 QIl a bond Me a bond NH 0 a bond Q3a OH
3602 CMe 0 QIl a bond Me a bond NH 0 a bond Q3d OH
3603 CMe 0 QIl a bond Me a bond NH 0 a bond Q3e OH
3604 CMe 0 QIl a bond Me a bond NH 0 a bond Q3f OH
3605 CMe 0 QIl a bond Me a bond NH 0 NH Q3a OH
3606 CMe 0 QIl a bond Me a bond NH 0 Ml Q3d OH 3607 CMe 0 QIl a bond Me a bond NH 0 NH Q3e OH
3608 CMe 0 QIl a bond Me a bond NH 0 NH Q3f OH
3609 CMe 0 QIl a bond Me a bond NH S a bond Q3a OH
3610 CMe 0 QIl a bond Me a bond NH S a bond Q3d OH
3611 CMe 0 QIl a bond Me a bond NH S a bond Q3e OH
3612 CMe 0 QIl a bond Me a bond NH S a bond Q3f OH
3613 CMe 0 QIl a bond Me a bond NH S NH Q3a OH
3614 CMe 0 QIl a bond Me a bond NH S NH Q3d OH
3615 CMe 0 QIl a bond Me a bond NH S NH Q3e OH
3616 CMe 0 QIl a bond Me a bond NH S NH Q3f OH
3617 CMe 0 QIm a bond Me a bond NH 0 a bond Q3a OH
3618 CMe 0 QIm a bond Me a bond NH 0 a bond Q3d OH
3619 CMe 0 QIm a bond Me a bond NH 0 a bond Q3e OH
3620 CMe 0 QIm a bond Me a bond NH 0 a bond Q3f OH
3621 CMe 0 QIm a bond Me a bond NH 0 NH Q3a OH
3622 CMe 0 QIm a bond Me a bond NH 0 NH Q3d OH
3623 CMe 0 QIm a bond Me a bond NH 0 NH Q3e OH
3624 CMe 0 QIm a bond Me a bond NH 0 NH Q3f OH
3625 CMe 0 QIm a bond Me a bond NH S a bond Q3a OH
3626 CMe 0 QIm a bond Me a bond NH S a bond Q3d OH
3627 CMe 0 QIm a bond Me a bond NH S a bond Q3e OH
3628 CMe 0 QIm a bond Me a bond NH S a bond Q3f OH
3629 CMe 0 QIm a bond Me a bond NH S NH Q3a OH
3630 CMe 0 QIm a bond Me a bond NH S NH Q3d OH
3631 CMe 0 QIm a bond Me a bond NH S NH Q3e OH
3632 CMe 0 QIm a bond Me a bond NH S NH Q3f OH
3633 CMe 0 QIn a bond Me a bond NH 0 a bond Q3a OH
3634 CMe 0 QIn a bond Me a bond NH 0 a bond Q3d OH
3635 CMe 0 QIn a bond Me a bond NH 0 a bond Q3e OH
3636 CMe 0 QIn a bond Me a bond NH 0 a bond Q3f OH
3637 CMe 0 QIn a bond Me a bond NH 0 NH Q3a OH
3638 CMe 0 QIn a bond Me a bond NH 0 NH Q3d OH
3639 CMe 0 QIn a bond Me a bond NH 0 NH Q3e OH
3640 CMe 0 QIn a bond Me a bond NH 0 NH Q3f OH
3641 CMe 0 QIn a bond Me a bond NH S a bond Q3a OH
3642 CMe 0 QIn a bond Me a bond NH S a bond Q3d OH 3643 CMe 0 QIn a bond Me a bond NH S a bond (}3e IDH
3644 CMe 0 QIn a bond Me a bond NH S a bond ( 23f ( 3H
3645 CMe 0 QIn a bond Me a bond NH S NH Q3a OH
3646 CMe 0 QIn a bond Me a bond NH S NH Q3d OH
3647 CMe 0 QIn a bond Me a bond NH S NH Q3e OH
3648 CMe 0 QIn a bond Me a bond NH S NH Q3f OH
3649 N NMe QIk' a bond Me a bond NH 0 a bond Q3a OH
3650 N NMe QIk' a bond Me a bond NH 0 a bond Q3d OH
3651 N NMe QIk' a bond Me a bond NH 0 a bond Q3e OH
3652 N NMe QIk' a bond Me a bond NH 0 a bond Q3f OH
3653 N NMe QIk' a bond Me a bond NH 0 NH Q3a OH
3654 N NMe QIk' a bond Me a bond NH 0 NH Q3d OH
3655 N NMe QIk' a bond Me a bond NH 0 NH Q3e OH
3656 N NMe QIk' a bond Me a bond NH 0 NH Q3f OH
3657 N NMe QIk' a bond Me a bond NH S a bond Q3a OH
3658 N NMe QIk' a bond Me a bond NH S a bond Q3d OH
3659 N NMe QIk' a bond Me a bond NH S a bond Q3e OH
3660 N NMe QIk' a bond Me a bond NH S a bond Q3f OH
3661 N NMe QIk' a bond Me a bond NH S NH Q3a OH
3662 N NMe QIk' a bond Me a bond NH S NH Q3d OH
3663 N NMe QIk' a bond Me a bond NH S NH Q3e OH
3664 N NMe QIk' a bond Me a bond NH S NH Q3f OH
3665 N NMe QlI' a bond Me a bond NH 0 a bond Q3a OH
3666 N NMe QiΓ a bond Me a bond NH 0 a bond Q3d OH
3667 N NMe QIl' a bond Me a bond NH 0 a bond Q3e OH
3668 N NMe Qir a bond Me a bond NH 0 a bond Q3f OH
3669 N NMe QIl' a bond Me a bond NH 0. NH Q3a OH
3670 N NMe QIl' a bond Me a bond NH 0 NH Q3d OH
3671 N NMe QlP a bond Me a bond NH 0 NH Q3e OH
3672 N NMe QlP a bond Me a bond NH 0 NH Q3f OH
3673 N NMe QlP a bond Me a bond NH S a bond Q3a OH
3674 N NMe QlP a bond Me a bond NH S a bond Q3d OH
3675 N NMe QlP a bond Me a bond NH S a bond Q3e OH
3676 N NMe QlP a bond Me a bond NH S a bond Q3f OH
3677 N NMe QlP a bond Me a bond NH S NH Q3a OH
3678 N NMe QlP a bond Me a bond NH S NH Q3d OH 3679 N NMe QlI' a bond Me a bond NH S NH Q3e OH
3680 N NMe QlI' a bond Me a bond NH S NH Q3f OH
3681 N NMe QIm' a bond Me a bond NH 0 a bond Q3a OH
3682 N NMe QIm' a bond Me a bond NH 0 a bond Q3d OH 3683 N NMe QIm' a bond Me a bond NH 0 a bond Q3e OH
3684 N NMe QIm' a bond Me a bond NH 0 a bond Q3f OH
3685 N NMe QIm' a bond Me a bond NH 0 NH Q3a OH
3686 N NMe QIm' a bond Me a bond NH 0 NH Q3d OH
3687 N NMe QIm' a bond Me a bond NH 0 NH Q3e OH 3688 N NMe QIm' a bond Me a bond NH 0 NH Q3f OH
3689 N NMe QIm' a bond Me a bond NH S a bond Q3a OH
3690 N NMe QIm' a bond Me a bond NH S a bond Q3d OH
3691 N NMe QIm' a bond Me a bond NH S a bond Q3e OH
3692 N NMe QIm' a bond Me a bond NH S a bond Q3f OH 3693 N NMe QIm' a bond Me a bond NH S NH Q3a OH
3694 N NMe QIm' a bond Me a bond NH S NH Q3d OH
3695 N NMe QIm' a bond Me a bond NH S NH Q3e OH
3696 N NMe QIm' a bond Me a bond NH S NH Q3f OH
3697 N NMe QIn' a bond Me a bond NH 0 a bond Q3a OH 3698 N NMe QIn' a bond Me a bond NH 0 a bond Q3d OH
3699 N NMe QIn' a bond Me a bond NH 0 a bond Q3e OH
3700 N NMe QIn' a bond Me a bond NH 0 a bond Q3f OH
3701 N NMe QIn' a bond Me a bond NH 0 NH Q3a OH
3702 N NMe QIn' a bond Me a bond NH 0 NH Q3d OH 3703 N NMe QIn' a bond Me a bond NH 0 NH Q3e OH
3704 N NMe QIn' a bond Me a bond NH 0 NH Q3f OH
3705 N NMe QIn' a bond Me a bond NH S a bond Q3a OH
3706 N NMe QIn' a bond Me a bond NH S a bond Q3d OH
3707 N NMe QIn' a bond Me a bond NH S a bond Q3e OH 3708 N NMe QIn' a bond Me a bond NH S a bond Q3f OH
3709 N NMe QIn' a bond Me a bond NH S NH Q3a OH
3710 N NMe QIn' a bond Me a bond NH S NH Q3d OH
3711 N NMe QIn' a bond Me a bond NH S NH Q3e OH
3712 N NMe QIn' a bond Me a bond NH S NH Q3f OH 3713 N NEt QIk' a bond Me a bond NH 0 a bond Q3a OH
3714 N NEt QIk' a bond Me a bond NH O a bond Q3d OH 3715 N NEt QIk' a bond Me a bond NH O a bond Q3e OH
3716 N NEt QIk' a bond Me a bond NH O a bond Q3f OH
3717 N NEt QIk' a bond Me a bond NH 0 NH Q3a OH
3718 N NEt QIk' a bond Me a bond NH 0 NH Q3d OH 3719 N NEt QIk' a bond Me a bond NH 0 NH Q3e OH
3720 N NEt QIk' a bond Me a bond NH 0 NH Q3f OH
3721 N NEt QIk' a bond Me a bond NH S a bond Q3a OH
3722 N NEt QIk' a bond Me a bond NH S a bond Q3d OH
3723 N NEt QIk' a bond Me a bond NH S a bond Q3e OH 3724 N NEt QIk' a bond Me a bond NH S a bond Q3f OH
3725 N NEt QIk' a bond Me a bond NH S NH Q3a OH
3726 N NEt QIk' a bond Me a bond NH S NH Q3d OH
3727 N NEt QIk' a bond Me a bond NH S NH Q3e OH
3728 N NEt QIk' a bond Me a bond NH S NH Q3f OH 3729 N NEt Ql1' a bond Me a bond NH O a bond Q3a OH
3730 N NEt Ql1' a bond Me a bond NH O a bond Q3d OH
3731 N NEt QIl' a bond Me a bond NH O a bond Q3e OH
3732 N NEt Ql1' a bond Me a bond NH O a bond Q3f OH
3733 N NEt Ql1' a bond Me a bond NH 0 NH Q3a OH 3734 N NEt QIl' a bond Me a bond NH 0 NH Q3d OH
3735 N NEt QIl' a bond Me a bond NH 0 NH Q3e OH
3736 N NEt QIl' a bond Me a bond NH 0 NH Q3f OH
3737 N NEt QIl' a bond Me a bond NH S a bond Q3a OH
3738 N NEt Ql1' a bond Me a bond NH S a bond Q3d OH 3739 N NEt QIl' a bond Me a bond NH S a bond Q3e OH
3740 N NEt Ql1' a bond Me a bond NH S a bond Q3f OH
3741 N NEt QIl' a bond Me a bond NH S NH Q3a OH
3742 N NEt QlP a bond Me a bond NH S NH Q3d OH
3743 N NEt QlP a bond Me a bond NH S NH Q3e OH 3744 N NEt QlP a bond Me a bond NH S NH Q3f OH
3745 N NEt QIm' a bond Me a b.ond NH O a bond Q3a OH
3746 N NEt QIm' a bond Me a bond NH O a bond Q3d OH
3747 N NEt QIm' a bond Me a bond NH O a bond Q3e OH
3748 N NEt QIm' a bond Me a bond NH O a bond Q3f OH 3749 N NEt QIm' a bond Me a bond NH 0 NH Q3a OH
3750 N NEt QIm' a bond Me a bond NH 0 NH Q3d OH 3751 N NEt QIm' a bond Me a bond NH 0 NH Q3e OH
3752 N NEt QIm' a bond Me a bond NH 0 NH Q3f OH
3753 N NEt QIm' a bond Me a bond NH S a bond Q3a OH
3754 N NEt QIm' a bond Me a bond NH S a bond Q3d OH 3755 N NEt QIm' a bond Me a bond NH S a bond Q3e OH
3756 N NEt QIm' a bond Me a bond NH S a bond Q3f OH
3757 N NEt QIm' a bond Me a bond NH S NH Q3a OH
3758 N NEt QIm' a bond Me a bond NH S NH Q3d OH
3759 N NEt QIm' a bond Me a bond NH S NH Q3e OH 3760 N NEt QIm' a bond Me a bond NH S NH Q3f OH
3761 N NEt QIn' a bond Me a bond NH O a bond Q3a OH
3762 N NEt QIn' a bond Me a bond NH O a bond Q3d OH
3763 N NEt QIn' a bond Me a bond NH O a bond Q3e OH
3764 N NEt QIn' a bond Me a bond NH O a bond Q3f OH 3765 N NEt QIn' a bond Me a bond NH 0 NH Q3a OH
3766 N NEt QIn' a bond Me a bond NH 0 NH Q3d OH
3767 N NEt QIn' a bond Me a bond NH 0 NH Q3e OH
3768 N NEt QIn' a bond Me a bond NH 0 NH Q3f OH
3769 N NEt QIn' a bond Me a bond NH S a bond Q3a OH 3770 N NEt QIn' a bond Me a bond NH S a bond Q3d OH
3771 N NEt QIn' a bond Me a bond NH S a bond Q3e OH
3772 N NEt QIn' a bond Me a bond NH S a bond Q3f OH
3773 N NEt QIn' a bond Me a bond NH S NH Q3a OH
3774 N NEt QIn' a bond Me a bond NH S NH Q3d OH 3775 N NEt QIn' a bond -Me a bond NH S NH Q3e OH
3776 N NEt QIn' a bond Me a bond NH S NH Q3f OH
3777 N S QIk' a bond Me a bond NH O a bond Q3a OH
3778 N S QIk' a bond Me a bond NH O a bond Q3d OH
3779 N S QIk' a bond Me a bond NH O a bond Q3e OH 3780 N S QIk' a bond Me a bond NH O a bond Q3f OH
3781 N S QIk' a bond Me a bond NH 0 NH Q3a OH
3782 N S QIk' a bond Me a bond NH 0 NH Q3d OH
3783 N S QIk' a bond Me a bond NH 0 NH Q3e OH
3784 N S QIk' a bond Me a bond NH 0 NH Q3f OH 3785 N S QIk' a bond Me a bond NH S a bond Q3a OH
3786 N S QIk' a bond Me a bond NH S a bond Q3d OH 3787 N S QIk' a bond Me a bond NH S a bond Q3e OH
3788 N S QIk' a bond Me a bond NH S a bond Q3f OH
3789 N S QIk' a bond Me a bond NH S NH Q3a OH
3790 N S QIk' a bond Me a bond NH S NH Q3d OH 3791 N S QIk' a bond Me a bond NH S NH Q3e OH
3792 N S QIk' a bond Me a bond NH S NH Q3f OH
3793 N S Ql I' a bond Me a bond NH O a bond Q3a OH
3794 N S Ql I' a bond Me a bond NH O a bond Q3d OH
3795 N S Ql I' a bond Me a bond NH O a bond Q3e OH 3796 N S QIl' a bond Me a bond NH O a bond Q3f OH
3797 N S QIl' a bond Me a bond NH 0 NH Q3a OH
3798 N S Ql I' a bond Me a bond NH 0 NH Q3d OH
3799 N S Ql I ' a bond Me a bond NH 0 NH Q3e OH
3800 N S Ql I' a bond Me a bond NH 0 NH Q3f OH 3801 N S Ql I' a bond Me a bond NH S a bond Q3a OH
3802 N S Ql I* a bond Me a bond NH S a bond Q3d OH
3803 N S Ql I' a bond Me a bond NH S a bond Q3e OH
3804 N S Ql I' a bond Me a bond NH S a bond Q3f OH
3805 N S QIl' a bond Me a bond NH S NH Q3a OH 3806 N S Ql I' a bond Me a bond NH S NH Q3d OH
3807 N S QIl' a bond Me a bond NH S NH Q3e OH
3808 N S Ql I' a bond Me a bond NH S NH Q3f OH
3809 N S QIm' a bond Me a bond NH O a bond Q3a OH
3810 N S QIm' a bond Me a bond NH O a bond Q3d OH 3811 N S QIm' a bond Me a bond NH O a bond Q3e OH
3812 N S QIm' a bond Me a bond NH O a bond Q3f OH
3813 N S QIm' a bond Me a bond NH 0 NH Q3a OH
3814 N S QIm' a bond Me a bond NH 0 NH Q3d OH
3815 N S QIm' a bond Me a bond NH 0 NH Q3e OH 3816 N S QIm' a bond Me a bond NH 0 NH Q3f OH
3817 N S QIm' a bond Me a bond NH S a bond Q3a OH
3818 N S QIm' a bond Me- a bond NH S a bond Q3d OH
3819 N S QIm' a bond Me a bond NH S a bond Q3e OH
3820 N S QIm' a bond Me a bond NH S a bond Q3f OH 3821 N S QIm' a bond Me a bond NH S NH Q3a OH
3822 N S QIm' a bond Me a bond NH S MI Q3d OH 3823 N S QIm' a bond Me a bond NH S NH Q3e OH
3824 N S QIm' a bond Me a bond NH S NH Q3f OH
3825 N S QIn' a bond Me a bond NH O a bond Q3a OH
3826 N S QIn' a bond Me a bond NH O a bond Q3d OH 3827 N S QIn' a bond Me a bond NH O a bond Q3e OH
3828 N S QIn' a bond Me a bond NH O a bond Q3f OH
3829 N S QIn' a bond Me a bond NH 0 NH Q3a OH
3830 N S QIn' a bond Me a bond NH 0 NH Q3d OH
3831 N S QIn' a bond Me a bond NH 0 NH Q3e OH 3832 N S QIn' a bond Me a bond NH 0 NH Q3f OH
3833 N S QIn' a bond Me a bond NH S a bond Q3a OH
3834 N S QIn' a bond Me a bond NH S a bond Q3d OH
3835 N S QIn' a bond Me a bond NH S a bond Q3e OH
3836 N S QIn' a bond Me a bond NH S a bond Q3f OH 3837 N S QIn' a bond Me a bond NH S NH Q3a OH
3838 N S QIn' a bond Me a bond NH S NH Q3d OH
3839 N S QIn' a bond Me a bond NH S NH Q3e OH
3840 N S QIn' a bond Me a bond NH S NH Q3f OH
3841 N 0 QIk' a bond Me a bond NH O a bond Q3a OH 3842 N 0 QIk' a bond Me a bond NH O a bond Q3d OH
3843 N 0 QIk' a bond Me a bond NH O a bond Q3e OH
3844 N 0 QIk' a bond Me a bond NH O a bond Q3f OH
3845 N 0 QIk' a bond Me a bond NH 0 NH Q3a OH
3846 N 0 QIk' a bond Me a bond NH 0 NH Q3d OH 3847 N 0 QIk' a bond Me a bond NH 0 NH Q3e OH
3848 N 0 QIk' a bond Me a bond NH 0 NH Q3f OH
3849 N 0 QIk' a bond Me a bond NH S a bond Q3a OH
3850 N 0 QIk' a bond Me a bond NH S a bond Q3d OH
3851 N 0 QIk' a bond Me a bond NH S a bond Q3e OH 3852 N 0 QIk' a bond Me a bond NH S a bond Q3f OH
3853 N 0 QIk' a bond Me a bond NH S NH Q3a OH
3854 N 0 QIk' a bond Me a bond NH S NH Q3d OH
3855 N 0 QIk' a bond Me a bond NH S NH Q3e OH
3856 N 0 QIk' a bond Me a bond NH S NH Q3f OH 3857 N 0 QIl' a bond Me a bond NH O a bond Q3a OH
3858 N 0 QIl' a bond Me a bond NH 0 a. bond Q3d OH 3859 N 0 QlI' a bond Me a bond NH O a bond Q3e OH
3860 N 0 QlI' a bond Me a bond NH O a bond Q3f OH
3861 N 0 QIl' a bond Me a bond NH 0 NH Q3a OH
3862 N 0 QIl' a bond Me a bond NH 0 NH Q3d OH 3863 N 0 QlI' a bond Me a bond NH 0 NH Q3e OH
3864 N 0 QIl' a bond Me a bond NH 0 NH Q3f OH
3865 N 0 QlI' a bond Me a bond NH S a bond Q3a OH
3866 N 0 QlI' a bond Me a bond NH S a bond Q3d OH
3867 N 0 QIl' a bond Me a bond NH S a bond Q3e OH 3868 N 0 QIl' a bond Me a bond NH S a bond Q3f OH
3869 N 0 QIl' a bond Me a bond NH S NH Q3a OH
3870 N 0 QIl' a bond Me a bond I S I 03d OH
3871 N 0 QlI' a bond Me a bond NH S NH Q3e OH
3872 N 0 QlI' a bond Me a bond NH S NH Q3f OH 3873 N 0 QIm' a bond Me a bond NH O a bond Q3a OH
3874 N 0 QIm' a bond Me a bond NH O a bond Q3d OH
3875 N 0 QIm' a bond Me a bond NH O a bond Q3e OH
3876 N 0 QIm' a bond Me a bond NH O a bond Q3f OH
3877 N 0 QIm' a bond Me a bond NH 0 NH Q3a OH 3878 N 0 QIm' a bond Me a bond NH 0 NH Q3d OH
3879 N 0 QIm' a bond Me a bond NH 0 NH Q3e OH
3880 N 0 QIm' a bond Me a bond NH 0 NH Q3f OH
3881 N 0 QIm' a bond Me a bond NH S a bond Q3a OH
3882 N 0 QIm' a bond Me a bond NH S a bond Q3d OH 3883 N 0 QIm' a bond Me a bond NH S a bond Q3e OH
3884 N 0 QIm' a bond Me a bond NH S a bond Q3f OH
3885 N 0 QIm' a bond Me a bond NH S NH Q3a OH
3886 N 0 QIm' a bond Me a bond NH S NH Q3d OH
3887 N 0 QIm' a bond Me a bond NH S NH Q3e OH 3888 N 0 QIm' a bond Me a bond NH S NH Q3f OH
3889 N 0 QIn' a bond Me a bond NH O a bond Q3a OH
3890 N 0 QIn' a bond Me a bond NH O a bond Q3d OH
3891 N 0 QIn' a bond Me a bond NH O a bond Q3e OH
3892 N 0 QIn' a bond Me a bond NH O a bond Q3f OH 3893 N 0 QIn' a bond Me a bond NH 0 NH Q3a OH
3894 N 0 QIn' a bond Me a bond NH 0 NH Q3d OH 3895 N 0 QIn' a bond Me a bond NH 0 NH Q3e OH
3896 N 0 QIn' a bond Me a bond NH 0 NH Q3f OH
3897 N 0 QIn' a bond Me a bond NH S a bond Q3a OH
3898 N 0 QIn' a bond Me a bond NH S a bond Q3d OH
5 3899 N 0 QIn' a bond Me a bond NH S a bond Q3e OH
3900 N 0 QIn' a bond Me a bond NH S a bond Q3f OH
3901 N 0 QIn' a bond Me a bond NH S NH Q3a OH
3902 N 0 QIn' a bond Me a bond NH S NH Q3d OH
3903 N 0 QIn' a bond Me a bond NH S NH Q3e OH 0 3904 N 0 QIn' a bond Me a bond NH S NH Q3f OH
3905 CH NMe QIk' a bond Me a bond NH 0 a bond Q3a OH
3906 CH NMe QIk' a bond Me a bond NH 0 a bond Q3d OH
3907 CH NMe QIk' a bond Me a bond NH 0 a bond Q3e OH
3908 CH NMe QIk' a bond Me a bond NH 0 a bond Q3f OH 5 3909 CH NMe QIk' a bond Me a bond NH 0 NH Q3a OH
3910 CH NMe QIk' a bond Me a bond NH 0 NH Q3d OH
3911 CH NMe QIk' a bond Me a bond NH 0 NH Q3e OH
3912 CH NMe QIk' a bond Me a bond NH 0 NH Q3f OH
3913 CH NMe QIk' a bond Me a bond NH S a bond Q3a OH o 3914 CH NMe QIk' a bond Me a bond NH S a bond Q3d OH
3915 CH NMe QIk' a bond Me a bond NH S a bond Q3e OH
3916 • CH NMe QIk' a bond Me a bond NH S a bond Q3f OH
3917 CH NMe QIk' a bond Me a bond NH S NH Q3a OH
3918 CH NMe QIk' a bond Me a bond NH S NH Q3d OH
5 3919 CH NMe QIk' a bond Me a bond NH S NH Q3e OH
3920 CH NMe QIk' a bond Me a bond NH S NH Q3f OH
3921 CH NMe QIl' a bond Me a bond NH 0 a bond Q3a OH
3922 CH NMe QIl' a bond Me a bond NH 0 a bond Q3d OH
3923 CH NMe QIl' a bond Me a bond NH 0 a bond Q3e OH o 3924' CH NMe QlI* a bond Me a bond NH 0 a bond Q3f OH
3925 CH NMe QIl' a bond Me a bond NH 0 NH Q3a OH
3926 CH NMe QIl' a bond Me a bond NH 0 NH Q3d OH
3927 CH NMe QIl' a bond Me a bond NH 0 NH Q3e OH
3928 CH NMe QlI' a bond Me a bond NH 0 NH Q3f OH
5 3929 CH NMe QIl' a bond Me a bond NH S a bond Q3a OH
3930 CH NMe QIl' a bond Me a bond NH S a .bond Q3d OH 3931 CH NMe QH' a bond Me a bond NH S a bond Q3e OH
3932 CH NMe QIl' a bond Me a bond NH S a bond Q3f OH
3933 CH NMe QH' a bond Me a bond NH S NH Q3a OH
3934 CH Me QIl' a bond Me a bond NH S NH Q3d OH 3935 CH NMe QH' a bond Me a bond NH S NH Q3e OH
3936 CH NMe QIl' a bond Me a bond Ml S NH Q3f OH
3937 CH NMe QIm' a bond Me a bond NH O a bond Q3a OH
3938 CH NMe QIm' a bond Me a bond NH O a bond Q3d OH
3939 CH NMe QIm' a bond Me a bond NH O a bond Q3e OH 3940 CH NMe QIm' a bond Me a bond NH O a bond Q3f OH
3941 CH NMe QIm' a bond Me a bond NH 0 NH Q3a OH
3942 CH NMe QIm' a bond Me a bond NH 0 NH Q3d OH
3943 CH NMe QIm' a bond Me a bond NH 0 NH Q3e OH
3944 CH NMe QIm' a bond Me a bond NH 0 NH Q3f OH 3945 CH NMe QIm' a bond Me a bond NH S a bond Q3a Ott
3946 CH NMe QIm' a bond Me a bond NH S a bond Q3d OH
3947 CH NMe QIm' a bond Me a bond NH S a bond Q3e OH
3948 CH NMe QIm' a bond Me a bond NH S a bond Q3f OH
3949 CH NMe QIm' a bond Me a bond NH S NH Q3a OH 3950 CH NMe QIm' a bond Me a bond NH S NH Q3d OH
3951 CH NMe QIm' a bond Me a bond NH S NH Q3e OH
3952 CH NMe QIm' a bond Me a bond NH S NH Q3f OH
3953 CH NMe QIn' a bond Me a bond NH O a bond Q3a OH
3954 CH NMe QIn' a bond Me a bond NH O a bond Q3d OH 3955 CH NMe QIn' a bond Me a bond NH O a bond Q3e OH
3956 CH NMe QIn' a bond Me a bond NH O a bond Q3f OH
3957 CH NMe QIn' a bond Me a bond NH 0 NH Q3a OH
3958 CH NMe QIn' a bond Me a bond NH 0 NH Q3d OH
3959 CH NMe QIn' a bond Me a bond NH 0 NH Q3e OH 3960 CH NMe QIn' a bond Me a bond NH 0 NH Q3f OH
3961 CH NMe QIn' a bond Me a bond NH S a bond Q3a OH
3962 CH NMe QIn' a bond Me • a bond NH S a bond Q3d OH
3963 CH NMe QIn' a bond Me a bond NH S a bond Q3e OH
3964 CH NMe QIn' a bond Me a bond NH S a bond Q3f OH 3965 CH NMe QIn' a bond Me a bond NH S NH Q3a OH
3966 CH NMe QIn' a bond Me a bond NH S NH Q3d OH 3967 CH NMe QIn' a bond Me a bond NH S NH Q3e OH
3968 CH NMe QIn' a bond Me a bond NH S NH Q3f OH
3969 CH NEt QIk' a bond Me a bond NH O a bond Q3a OH
3970 CH NEt QIk' a bond Me a bond NH O a bond Q3d OH 3971 CH NEt QIk' a bond Me a bond' NH O a bond Q3e OH
3972 CH NEt QIk' a bond Me a bond NH O a bond Q3f OH
3973 CH NEt QIk' a bond Me a bond NH 0 NH Q3a OH
3974 CH NEt QIk' a bond Me a bond NH 0 NH Q3d OH
3975 CH NEt QIk' a bond Me a bond NH 0 NH Q3e OH 3976 CH NEt QIk' a bond Me a bond NH 0 NH Q3f OH
3977 CH NEt QIk' a bond Me a bond NH S a bond Q3a OH
3978 CH NEt QIk' a bond Me a bond NH S a bond Q3d OH
3979 CH NEt QIk' a bond Me a bond NH S a bond Q3e OH
3980 CH NEt QIk' a bond Me a bond NH S a bond Q3f OH 3981 CH NEt QIk' a bond Me a bond NH S NH Q3a OH
3982 CH NEt QIk' a bond Me a bond NH S NH Q3d OH
3983 CH NEt QIk' a bond Me a bond NH S NH Q3e OH
3984 CH NEt QIk' a bond Me a bond NH S NH Q3f OH
3985 CH NEt QIl' a' bond Me a bond NH O a bond Q3a OH 3986 CH NEt QH' a bond Me a bond NH O a bond Q3d OH
3987 CH NEt QH' a bond Me a bond NH O a bond Q3e OH
3988 CH NEt" QlI' a bond Me a bond NH O a bond Q3f OH
3989 CH NEt QH' a bond Me a bond NH 0 NH Q3a OH
3990 CH NEt QH' a bond Me a bond NH 0 NH Q3d OH 3991 CH NEt QH' a bond Me a bond NH 0 NH Q3e OH
3992 CH NEt QIl' a bond Me a bond NH 0 NH Q3f OH
3993 CH NEt QIl' a bond Me a bond NH S a bond Q3a OH
3994 CH NEt QIl' a bond Me. a bond NH S a bond Q3d OH
3995 CH NEt QlT a bond Me a bond NH S a bond Q3e OH 3996 CH NEt QIl' a bond Me a bond NH S a bond Q3f OH
3997 CH NEt QIl' a bond Me a bond NH S NH Q3a OH
3998 CH NEt QIl' a bond Me a bond NH S NH Q3d OH
3999 CH NEt QIl' a bond Me a bond NH S NH Q3e OH
4000 CH NEt QlI' a bond Me a bond NH S NH Q3f OH 4001 CH NEt QIm' a bond Me a bond NH O a bond Q3a OH
4002 CH NEt QIm' a bond Me a bond NH O a bond Q3d OH 4003 CH NEt QIm' a bond Me a bond NH O a bond Q3e OH
4004 CH NEt QIm' a bond Me a bond NH O a bond Q3f OH
4005 CH NEt QIm' a bond Me a bond NH 0 NH Q3a OH
4006 CH NEt QIm' a bond Me a bond NH 0 NH Q3d OH 4007 CH NEt QIm' a bond Me a bond NH 0 NH Q3e OH
4008 CH NEt QIm' a bond Me a bond NH 0 NH Q3f OH
4009 CH NEt QIm' a bond Me a bond NH S a bond Q3a OH
4010 CH NEt QIm' a bond Me a bond NH S a bond Q3d OH
4011 CH NEt QIm' a bond Me a bond NH S a bond Q3e OH 4012 CH NEt QIm' a bond Me a bond NH S a bond Q3f OH
4013 CH NEt QIm' a bond Me a bond NH S NH Q3a OH
4014 CH NEt QIm' a bond Me a bond NH S NH Q3d OH
4015 CH NEt QIm' a bond Me a bond NH S NH Q3e OH
4016 CH NEt QIm' a bond Me a bond NH S NH Q3f OH 4017 CH NEt QIn' a bond Me a bond NH O a bond Q3a OH
4018 CH NEt QIn' a bond Me a bond NH O a bond Q3d OH
4019 CH NEt QIn' a bond Me a bond NH O a bond Q3e OH
4020 CH NEt QIn' a bond Me a bond NH O a bond Q3f OH
4021 CH NEt QIn' a bond Me a bond NH 0 NH Q3a OH 4022 CH NEt QIn' a bond Me a bond NH 0 NH Q3d OH
4023 CH NEt QIn' a bond Me a bond NH 0 NH Q3e OH
4024 CH NEt QIn' a bond Me a bond NH 0 NH Q3f OH
4025 CH NEt QIn' a bond Me a bond NH S a bond Q3a OH
4026 CH NEt QIn' a bond Me a bond NH S a bond Q3d OH 4027 CH NEt QIn' a bond Me a bond NH S a bond Q3e OH
4028 CH NEt QIn' a bond Me a bond NH S a bond Q3f OH
4029 CH NEt QIn' a bond Me a bond NH S NH Q3a OH
4030 CH NEt QIn' a bond Me a bond NH S NH Q3d OH
4031 CH NEt QIn' a bond Me a bond NH S NH Q3e OH 4032 CH NEt QIn' a bond Me a bond NH S NH Q3f OH
4033 CH S QIk' a bond Me a bond NH O a bond Q3a OH
4034 CH S QIk' a bond Me • a bond NH O a bond Q3d OH
4035 CH S QIk' a bond Me a bond NH O a bond Q3e OH
4036 CH S QIk' a bond Me a bond NH O a bond Q3f OH 4037 CH S QIk' a bond Me a bond NH 0 NH Q3a OH
4038 CH S QIk' a bond Me a bond I 0 I 03d OH 4039 CH S QIk' a bond Me a bond NH 0 NH Q3e OH
4040 CH S QIk' a bond Me a bond NH 0 NH Q3f OH
4041 CH S QIk' a bond Me a bond NH S a bond Q3a OH
4042 CH S QIk' a bond Me a bond NH S a bond Q3d OH 4043 CH S QIk' a bond Me a bond NH S a bond Q3e OH
4044 CH S QIk' a bond Me a bond NH S a bond Q3f OH
4045 CH S QIk' a bond Me a bond NH S NH Q3a OH
4046 CH S QIk' a bond Me a bond NH S NH Q3d OH
4047 CH S QIk' a bond Me a bond NH S NH Q3e OH 4048 CH S QIk' a bond Me a bond NH S NH Q3f OH
4049 CH S QIl' a bond Me a bond NH O a bond Q3a OH
4050 CH S QIl' a bond Me a bond NH O a bond Q3d OH
4051 CH S QlI' a bond Me a bond NH O a bond Q3e OH
4052 CH S QlI' a bond Me a bond NH O a bond Q3f OH 4053 CH S QlI' a bond Me a bond NH 0 NH Q3a OH
4054 CH S QlI' a bond Me a bond NH 0 NH Q3d OH
4055 CH S QIl' a bond Me a bond NH 0 NH Q3e OH
4056 CH S QlI' a bond Me a bond NH 0 NH Q3f OH
4057 CH S QlI' a bond Me a bond NH S a bond Q3a OH 4058 CH S QlI' a bond Me a bond NH S a bond Q3d OH
4059 CH S QlI' a bond Me a bond NH S a bond Q3e OH
4060 CH S QlI' a bond Me a bond NH S a bond Q3f OH
4061 CH S" QIl' a bond Me a bond NH S NH Q3a OH
4062 CH S QlI' a bond Me a bond NH S NH Q3d OH 4063 CH S QlI' a bond Me a bond NH S NH Q3e OH
4064 CH S QIl' a bond Me a bond NH S NH Q3f OH
4065 CH S QIm' a bond Me a bond NH O a bond Q3a OH
4066 CH S QIm' a bond Me a bond NH O a bond Q3d OH
4067 CH S QIm' a bond Me a bond NH O a bond Q3e OH 4068 CH S QIm' a bond Me a bond NH O a bond Q3f OH
4069 CH S QIm' a bond Me a bond NH 0 NH Q3a OH
4070 CH S QIm' a bond Me a bond NH 0 NH Q3d OH
4071 CH S QIm' a bond Me a bond NH 0 NH Q3e OH
4072 CH S QIm' a bond Me a bond NH 0 NH Q3f OH 4073 CH S QIm' a bond Me a bond NH S a bond Q3a OH
4074 CH S QIm' a bond Me a bond NH S a bond Q3d OH 4075 CH S QIm' a bond Me a bond NH S a bond Q3e OH
4076 CH S QIm' a bond Me a bond NH S a bond Q3f OH
4077 CH S QIm' a bond Me a bond NH S NH Q3a OH
4078 CH S QIm' a bond Me a bond NH S NH Q3d OH 4079 CH S QIm' a bond Me a bond NH S NH Q3e OH
4080 CH S QIm' a bond Me a bond NH S NH Q3f OH
4081 CH S QIn' a bond Me a bond NH O a bond Q3a OH
4082 CH S QIn' a bond Me a bond NH O a bond Q3d OH
4083 CH S QIn' a bond Me a bond NH O a bond Q3e OH 4084 CH S QIn' a bond Me a bond NH O a bond Q3f OH
4085 CH S QIn' a bond Me a bond NH 0 NH Q3a OH
4086 CH S QIn' a bond Me a bond NH 0 NH Q3d OH
4087 CH S QIn' a bond Me a bond NH 0 NH Q3e OH
4088 CH S QIn' a bond Me a bond NH 0 NH Q3f OH 4089 CH S QIn' a bond Me a bond NH S a bond Q3a OH
4090 CH S QIn' a bond Me a bond NH S a bond Q3d OH
4091 CH S QIn' a bond Me a bond NH S a bond Q3e OH
4092 CH S QIn' a bond Me a bond NH S a bond Q3f OH
4093 CH S QIn' a bond Me a bond NH S NH Q3a OH 4094 CH S QIn' a bond Me a bond NH S NH Q3d OH
4095 CH S QIn' a bond Me a bond NH S NH Q3e OH
4096 CH S QIn' a bond Me a bond NH S NH Q3f OH
4097 CH 0 QIk' a bond Me a bond NH O a bond Q3a OH
4098 CH 0 QIk' a bond Me a bond NH O a bond Q3d OH 4099 CH 0 QIk' a bond Me a bond NH O a bond Q3e OH
4100 CH 0 QIk' a bond Me a bond NH O a bond Q3f OH
4101 CH 0 QIk' a bond Me a bond NH 0 NH Q3a OH
4102 CH 0 QIk' a bond Me a bond NH 0 NH Q3d OH
4103 CH 0 QIk' a bond Me a bond NH 0 NH Q3e OH 4104 CH 0 QIk' a bond Me a bond NH 0 NH Q3f OH
4105 CH 0 QIk' a bond Me a bond NH S a bond Q3a OH
4106 CH 0 QIk' a bond Me a bond NH S a bond Q3d OH
4107 CE 0 QIk' a bond Me a bond NH S a bond Q3e OH
4108 CH 0 QIk' a bond Me a bond NH S a bond Q3f OH 4109 CH 0 QIk' a bond Me a bond NH S NH Q3a OH
4110 CH 0 QIk' a bond Me a bond NH S NH Q3d OH 4111 CH 0 QIk' a bond Me a bond NH S NH Q3e OH
4112 CH 0 QIk' a bond Me a bond NH S NH Q3f OH
4113 CH 0 QIl' a bond Me a bond NH O a bond Q3a OH
4114 CH 0 QIl' a bond Me a bond NH O a bond Q3d OH 4115 CH 0 QIl' a bond Me a bond' NH O a bond Q3e OH
4116 CH 0 QIl' a bond Me a bond NH O a bond Q3f OH
4117 CH 0 QIl' a bond Me a bond NH 0 NH Q3a OH
4118 CH 0 QIl' a bond Me a bond NH 0 NH Q3d OH
4119 CH 0 QIl' a bond Me a bond NH 0 NH Q3e OH 4120 CH 0 QIl' a bond Me a bond NH 0 NH Q3f OH
4121 CH 0 QlI' a bond Me a bond NH S a bond Q3a OH
4122 CH 0 QIl' a bond Me a bond NH S a bond Q3d OH
4123 CH 0 QIl' a bond Me a bond NH S a bond Q3e OH
4124 CH 0 QIl' a bond Me a bond NH S a bond Q3f OH 4125 CH 0 QIl' a bond Me a bond NH S NH Q3a OH
4126 CH 0 QIl' a bond Me a bond NH S NH Q3d OH
4127 CH 0 QIl' a bond Me a bond NH S NH Q3e OH
4128 CH 0 QIl' a bond Me a bond NH S NH Q3f OH
4129 CH 0 QIm' a bond Me a bond NH O a bond Q3a OH 4130 CH 0 QIm' a bond Me a bond NH O a bond Q3d OH
4131 CH 0 QIm' a bond Me a bond NH O a bond Q3e OH
4132 CH 0 QIm' a bond Me a bond NH O a bond Q3f OH
4133 CH 0 QIm' a bond Me a bond NH 0 NH Q3a OH
4134 CH 0 QIm' a bond Me a bond NH 0 NH Q3d OH 4135 CH 0 QIm' a bond Me a bond NH 0 NH Q3e OH
4136 CH 0 QIm' a bond Me a bond NH 0 NH Q3f OH
4137 CH 0 QIm' a bond Me a bond NH S a bond Q3a OH
4138 CH 0 QIm' a bond Me a bond NH S a bond Q3d OH
4139 CH 0 QIm' a bond Me a bond NH S a bond Q3e OH 4140 CH 0 QIm' a bond Me a bond NH S a bond Q3f OH
4141 CH 0 QIm' a bond Me a bond NH S NH Q3a OH
4142 CH 0 QIm' a bond Me a bond NH S NH Q3d OH
4143 CH 0 QIm' a bond Me a bond NH S NH Q3e OH
4144 CH 0 QIm' a bond Me a bond NH S NH Q3f OH 4145 CH 0 QIn' a bond Me a bond NH O a bond Q3a OH
4146 CH 0 QIn' a bond Me a bond NH O a bond Q3d OH 4147 CH 0 QIn' a bond Me a bond NH 0 a bond Q3e OH
4148 CH 0 QIn' a bond Me a bond NH 0 a bond Q3f OH
4149 CH 0 QIn' a bond Me a bond NH 0 NH Q3a ( )H
4150 CH 0 QIn' a bond Me a bond NH 0 NH Q3d ( )H
4151 CH 0 QIn' a bond Me a bond NH 0 NH Q3e ( )H
4152 CH 0 QIn' a bond Me a bond NH 0 NH Q3f ( )H
4153 CH 0 QIn' a bond Me a bond NH S a bond Q3a OH
4154 CH 0 QIn' a bond Me a bond NH S a bond Q3d OH
4155 CH 0 QIn' a bond Me a bond NH S a bond Q3e OH
4156 CH 0 QIn' a bond Me a bond NH S a bond Q3f OH
4157 CH 0 QIn' a bond Me a bond NH S NH Q3a ( )H
4158 CH 0 QIn' a bond Me a bond NH S NH Q3d ( )H
4159 CH 0 QIn' a bond Me a bond NH S NH Q3e ( )H
4160 CH 0 QIn' a bond Me a bond NH S NH Q3f ( )H
4161 CMe NMe QIk' a bond Me a bond NH 0 a bond Q3a OH
4162 CMe NMe QIk' a bond Me a bond NH 0 a bond Q3d OH
4163 CMe NMe QIk' a bond Me a bond NH 0 a bond Q3e OH
4164 CMe NMe QIk' a bond Me a bond NH 0 a bond Q3f OH
4165 CMe NMe QIk' a bond Me a bond NH 0 NH Q3a OH
4166 CMe NMe QIk' a bond Me a bond NH 0 NH Q3d OH
4167 CMe NMe QIk' a bond Me a bond NH 0 NH Q3e OH
4168 CMe NMe QIk' a bond Me a bond NH 0 NH Q3f OH
4169 CMe NMe QIk' a bond Me a bond NH S a bond Q3a OH
4170 CMe NMe QIk' a bond Me a bond NH S a bond Q3d OH
4171 CMe NMe QIk' a bond Me a bond NH S a bond Q3e OH
4172 CMe NMe QIk' a bond Me a bond NH S a bond Q3f OH
4173 CMe NMe QIk' a bond Me a bond NH S NH Q3a OH
4174 CMe NMe QIk' a bond Me a bond NH S NH Q3d OH
4175 CMe NMe QIk' a bond Me a bond NH S NH Q3e OH
4176 CMe NMe QIk' a bond Me a bond NH S NH Q3f OH
4177 CMe NMe QIl' a bond Me a b.ond NH 0 a bond Q3a OH
4178 CMe NMe QIl' a bond Me- a bond NH 0 a bond Q3d OH
4179 CMe NMe QIΓ a bond Me a bond NH 0 a bond Q3e OH
4180 CMe NMe QlI' a bond Me a bond NH 0 a bond Q3f OH
4181 CMe NMe QIl' a bond Me a bond NH 0 NH Q3a OH
4182 CMe NMe Qir a bond Me a bond NH 0 NH Q3d OH 4183 CMe NMe QH' a bond Me a bond NH 0 NH Q3e OH
4184 CMe NMe QIl' a bond Me a bond NH 0 NH Q3f OH
4185 CMe NMe QH' a bond Me a bond NH S a bond Q3a OH
4186 CMe NMe QH' a bond Me a bond NH S a bond Q3d OH 4187 CMe NMe QlT a bond Me a bond NH S a bond Q3e OH
4188 CMe NMe QH' a bond Me a bond NH S a bond Q3f OH
4189 CMe NMe QIl' a bond Me a bond NH S NH Q3a OH
4190 CMe NMe QH' a bond Me a bond NH S NH Q3d OH
4191 CMe NMe QIl' a bond Me a bond NH S NH Q3e OH 4192 CMe NMe QlT a bond Me a bond NH S NH Q3f OH
4193 CMe NMe QIm' a bond Me a bond NH O a bond Q3a OH
4194 CMe NMe QIm' a bond Me a bond NH O a bond Q3d OH
4195 CMe NMe QIm' a bond Me a bond NH O a bond Q3e OH
4196 CMe NMe QIm' a bond Me a bond NH O a bond Q3f OH 4197 CMe NMe QIm' a bond Me a bond NH 0 NH Q3a OH
4198 CMe NMe QIm' a bond Me a bond NH 0 NH Q3d OH
4199 CMe NMe QIm' a bond Me a bond NH 0 NH Q3e OH
4200 CMe NMe QIm' a bond Me a bond NH 0 NH Q3f OH
4201 CMe NMe QIm' a bond Me a bond NH S a bond Q3a OH 4202 CMe NMe QIm' a bond Me a bond NH S a bond Q3d OH
4203 CMe NMe QIm' a bond Me a bond NH S a bond Q3e OH
4204 CMe NMe QIm' a bond Me a bond NH S a bond Q3f OH
4205 CMe NMe QIm' a bond Me a bond NH S NH Q3a OH
4206 CMe NMe QIm' a bond Me a bond NH S NH Q3d OH 4207 CMe NMe QIm' a bond Me a bond NH S NH Q3e OH
4208 CMe NMe QIm' a bond Me a bond NH S NH Q3f OH
4209 CMe NMe QIn' a bond Me a bond NH O a bond Q3a OH
4210 CMe NMe QIn' a bond Me a bond NH O a bond Q3d OH
4211 CMe NMe QIn' a bond Me a bond NH O a bond Q3e OH 4212 CMe NMe QIn' a bond Me a bond NH O a bond Q3f OH
4213 CMe NMe QIn' a bond Me a bond NH 0 NH Q3a OH
4214 CMe NMe QIn' a bond Me a bond NH 0 NH Q3d OH
4215 CMe NMe QIn' a bond Me a bond NH 0 NH Q3e OH
4216 CMe NMe QIn' a bond Me a bond NH 0 NH Q3f OH 4217 CMe NMe QIn' a bond Me a bond NH S a bond Q3a OH
4218 CMe NMe QIn' a bond Me a bond NH S a. bond ,Q3d OH 4219 CMe NMe QIn' a bond Me a bond NH S a bond Q3e OH
4220 CMe NMe QIn' a bond Me a bond NH S a bond Q3f OH
4221 CMe NMe QIn' a bond Me a bond NH S NH Q3a OH
4222 CMe NMe QIn' a bond Me a bond NH S NH Q3d OH 4223 CMe NMe QIn' a bond Me a bond NH S NH Q3e OH
4224 CMe NMe QIn' a bond Me a bond NH S NH Q3f OH
4225 CMe NEt QIk' a bond Me a bond NH O a bond Q3a OH
4226 CMe NEt QIk' a bond Me a bond NH O a bond Q3d OH
4227 CMe NEt QIk' a bond Me a bond NH O a bond Q3e OH 4228 CMe NEt QIk' a bond Me a bond NH O a bond Q3f OH
4229 CMe NEt QIk' a bond Me a bond NH 0 NH Q3a OH
4230 CMe NEt QIk' a bond Me a bond NH 0 NH Q3d OH
4231 CMe NEt QIk' a bond Me a bond NH 0 NH Q3e OH
4232 CMe NEt QIk' a bond Me a bond NH 0 NH Q3f OH 4233 CMe NEt QIk' a bond Me a bond NH S a bond Q3a OH
4234 CMe NEt QIk' a bond Me a bond NH S a bond Q3d OH
4235 CMe NEt QIk' a bond Me a bond NH S a bond Q3e OH
4236 CMe NEt QIk' a bond Me a bond NH S a bond Q3f OH
4237 CMe NEt QIk' a bond Me a bond NH S NH Q3a OH 4238 CMe NEt QIk' a bond Me a bond NH S NH Q3d OH
4239 CMe NEt QIk' a bond Me a bond NH S NH Q3e OH
4240 CMe NEt QIk' a bond Me a bond NH S NH Q3f OH
4241 CMe NEt QlT a bond Me a bond NH O a bond Q3a OH
4242 CMe NEt QIl' a bond Me a bond NH O a bond Q3d OH 4243 CMe NEt QIl' a bond Me a bond NH O a bond Q3e OH
4244 CMe NEt QH' a bond Me a bond NH O a bond Q3f OH
4245 CMe NEt QH' a bond Me a bond NH 0 NH Q3a OH
4246 CMe NEt QIl' a bond Me a bond NH 0 NH Q3d OH
4247 CMe NEt QIl' a bond Me a bond NH 0 NH Q3e OH 4248 CMe NEt QIl' a bond Me a bond NH 0 MI Q3f OH
4249 CMe NEt QH' a bond Me a bond NH S a bond Q3a OH
4250 CMe NEt QH' a bond Me a bond NH S a bond Q3d OH
4251 CMe NEt QIl' a bond Me a bond NH S a bond Q3e OH
4252 CMe NEt QIl' a bond Me a bond NH S a bond Q3f OH 4253 CMe NEt QIl' a bond Me a bond NH S NH Q3a OH
4254 CMe NEt QH' a bond Me a bond NH S NH Q3d OH 4255 CMe NEt QIl' a bond Me a bond NH S NH Q3e OH
4256 CMe NEt QIl' a bond Me a bond NH S NH Q3f OH
4257 CMe NEt QIm' a bond Me a bond NH O a bond Q3a OH
4258 CMe NEt QIm' a bond Me a bond NH O a bond Q3d OH 4259 CMe NEt QIm' a bond Me a bond NH O a bond Q3e OH
4260 CMe NEt QIm' a bond Me a bond NH O a bond Q3f OH
4261 CMe NEt QIm' a bond Me a bond NH 0 NH Q3a OH
4262 CMe NEt QIm' a bond Me a bond NH 0 NH Q3d OH
4263 CMe NEt QIm' a bond Me a bond NH 0 NH Q3e OH 4264 CMe NEt QIm' a bond Me a bond NH 0 NH Q3f OH
4265 CMe NEt QIm' a bond Me a bond NH S a bond Q3a OH
4266 CMe NEt QIm' a bond Me a bond NH S a bond Q3d OH
4267 CMe NEt QIm' a bond Me a bond NH S a bond Q3e OH
4268 CMe NEt QIm' a bond Me a bond NH S a bond Q3f OH 4269 CMe NEt QIm' a bond Me a bond NH S NH Q3a OH
4270 CMe NEt QIm' a bond Me a bond NH S NH Q3d OH
4271 CMe NEt QIm' a bond Me a bond NH S NH Q3e OH
4272 CMe NEt QIm' a bond Me a bond NH S NH Q3f OH
4273 CMe NEt QIn' a bond Me a bond NH O a bond Q3a OH 4274 CMe NEt QIn' a bond Me a bond NH O a bond Q3d OH
4275 CMe NEt QIn' a bond Me a bond NH O a bond Q3e OH
4276 CMe Net QIn' a bond Me a bond NH O a bond Q3f OH
4277 CMe NEt QIn' a bond Me a bond NH 0 NH Q3a OH
4278 CMe NEt QIn' a bond Me a bond NH 0 NH Q3d OH 4279 CMe NEt QIn' a bond Me a bond NH 0 NH Q3e OH
4280 CMe NEt QIn' a bond Me a bond NH 0 NH Q3f OH
4281 CMe NEt QIn' a bond Me a bond NH S a bond Q3a OH
4282 CMe NEt QIn' a bond Me a bond NH S a bond Q3d OH
4283 CMe NEt QIn' a bond Me a bond NH S a bond Q3e OH 4284 CMe NEt QIn' a bond Me a bond NH S a bond Q3f OH
4285 CMe NEt QIn' a bond Me a bond NH S NH Q3a OH
4286 CMe NEt QIn' a bond Me a bond NH S NH Q3d OH
4287 CMe NEt QIn' a bond Me a bond NH S NH Q3e OH
4288 CMe NEt QIn' a bond Me a bond NH S NH Q3f OH 4289 CMe S QIk' a bond Me a bond NH O a bond Q3a OH
4290 CMe S QIk' a bond Me a bond NH O a. bond Q3d OH 4291 CMe S QIk' a bond Me a bond NH O a bond Q3e OH
4292 CMe S QIk' a bond Me a bond NH O a bond Q3f OH
4293 CMe S QIk' a bond Me a bond NH 0 NH Q3a OH
4294 CMe S QIk' a bond Me a bond NH 0 NH Q3d OH 4295 CMe S QIk' a bond Me a bond NH 0 NH Q3e OH
4296 CMe S QIk' a bond Me a bond NH 0 NH Q3f OH
4297 CMe S QIk' a bond Me a bond NH S a bond Q3a OH
4298 CMe S QIk' a bond Me a bond NH S a bond Q3d OH
4299 CMe S QIk' a bond Me a bond NH S a bond Q3e OH 4300 CMe S QIk' a bond Me a bond NH S a bond Q3f OH
4301 CMe S QIk' a bond Me a bond NH S NH Q3a OH
4302 CMe S QIk' a bond Me a bond NH S NH Q3d OH
4303 CMe S QIk' a bond Me a bond NH S NH Q3e OH
4304 CMe S QIk' a bond Me a bond NH S NH Q3f OH 4305 CMe S QIl' a bond Me a bond NH O a bond Q3a OH
4306 CMe S QIl' a bond Me a bond NH O a bond Q3d OH
4307 CMe S QIl' a bond Me a bond NH O a bond Q3e OH
4308 CMe S QH' a bond Me a bond NH O a bond Q3f OH
4309 CMe S QH' a bond Me a bond NH 0 NH Q3a OH 4310 CMe S QH' a bond Me a bond NH 0 NH Q3d OH
4311 CMe S QIl' a bond Me a bond NH 0 NH Q3e OH
4312 CMe S QH' a bond Me a bond NH 0 NH Q3f OH
4313 CMe S QIl' a bond Me a bond NH S a bond Q3a OH
4314 CMe S QIl' a bond Me a bond NH S a bond Q3d OH 4315 CMe S QH' a bond Me a bond NH S a bond Q3e OH
4316 CMe S QIl' a bond Me a bond NH S a bond Q3f OH
4317 CMe S QIl' a bond Me a bond NH S NH Q3a OH
4318 CMe S QH' a bond Me a bond i S 1 03d OH
4319 CMe S QIl' a bond Me a bond NH S NH Q3e OH 4320 CMe S QH' a bond Me a bond NH S NH Q3f OH
4321 CMe S QIm' a bond Me a bond NH O a bond Q3a OH
4322 CMe S QIm' a bond Me a bond NH O a bond Q3d OH
4323 CMe S QIm' a bond Me a bond NH O a bond Q3e OH
4324 CMe S QIm' a bond Me a bond NH O a bond Q3f OH 4325 CMe S QIm' a bond Me a bond NH 0 NH Q3a OH
4326 CMe S QIm' a bond Me a bond NH 0 NH Q3d OH 4327 CMe S QIm' a bond Me a bond NH 0 NH Q3e OH
4328 CMe S QIm' a bond Me a bond NH 0 NH Q3f OH
4329 CMe S QIm' a bond Me a bond NH S a bond Q3a OH
4330 CMe S QIm' a bond Me a bond NH S a bond Q3d OH 4331 CMe S QIm' a bond Me a bond NH S a bond Q3e OH
4332 CMe S QIm' a bond Me a bond NH S a bond Q3f OH
4333 CMe S QIm' a bond Me a bond NH S NH Q3a OH
4334 CMe S QIm' a bond Me a bond NH S NH Q3d OH
4335 CMe S QIm' a bond Me a bond NH S NH Q3e OH 4336 CMe S QIm' a bond Me a bond NH S NH Q3f OH
4337 CMe S QIn' a bond Me a bond NH O a bond Q3a OH
4338 CMe S QIn' a bond Me a bond NH O a bond Q3d OH
4339 CMe S QIn' a bond Me a bond NH O a bond Q3e OH
4340 CMe S QIn' a bond Me a bond NH O a bond Q3f OH 4341 CMe S QIn' a bond Me a bond NH 0 NH Q3a OH
4342 CMe S QIn' a bond Me a bond NH 0 NH Q3d OH
4343 CMe S QIn' a bond Me a bond NH 0 NH Q3e OH
4344 CMe S QIn' a bond Me a bond NH 0 NH Q3f OH
4345 CMe S QIn' a bond Me a bond NH S a bond Q3a OH 4346 CMe S QIn' a bond Me a bond NH S a bond Q3d OH
4347 CMe S QIn' a bond Me a bond NH S a bond Q3e OH
4348 CMe S QIn' a bond Me a 'bond NH S a bond Q3f OH
4349 CMe S QIn' a bond Me a bond NH S NH Q3a OH
4350 CMe S QIn' a bond Me a bond NH S NH Q3d OH 4351 CMe S QIn' a bond Me a bond NH S NH Q3e OH
4352 CMe S QIn' a bond Me a bond NH S NH Q3f OH
4353 CMe 0 QIk' a bond Me a bond NH O a bond Q3a OH
4354 CMe 0 QIk' a bond Me a bond NH O a bond Q3d OH
4355 CMe 0 QIk' a bond Me a bond NH O a bond Q3e OH 4356 CMe 0 QIk' a bond Me a bond NH O a bond Q3f OH
4357 CMe 0 QIk' a bond Me a bond NH 0 NH Q3a OH
4358 CMe 0 QIk' a bond Me a bond NH 0 NH Q3d OH
4359 CMe 0 QIk' a bond Me a bond NH 0 NH Q3e OH
4360 CMe 0 QIk' a bond Me a bond NH 0 NH Q3f OH 4361 CMe 0 QIk' a bond Me a bond NH S a bond Q3a OH
4362 CMe 0 QIk' a bond Me a bond NH S a bond Q3d OH 4363 CMe 0 QIk' a bond Me a bond NH S a bond Q3e OH
4364 CMe 0 QIk' a bond Me a bond NH S a bond Q3f OH
4365 CMe 0 QIk' a bond Me a bond NH S NH Q3a OH
4366 CMe 0 QIk' a bond Me a bond NH S NH Q3d OH 4367 CMe 0 QIk' a bond Me a bond NH S NH Q3e OH
4368 CMe 0 QIk' a bond Me a bond NH S NH Q3f OH
4369 CMe 0 QU' a bond Me a bond NH O a bond Q3a OH
4370 CMe 0 QH' a bond Me a bond NH O a bond Q3d OH
4371 CMe 0 QH' a bond Me a bond NH O a bond Q3e OH 4372 CMe 0 QH' a bond Me a bond NH O a bond Q3f OH
4373 CMe 0 QIl' a bond Me a bond NH 0 NH Q3a OH
4374 CMe 0 QIl' a bond Me a bond NH 0 NH Q3d OH
4375 CMe 0 QIl' a bond Me a bond NH 0 NH Q3e OH
4376 CMe 0 QIl' a bond Me a bond NH 0 NH Q3f OH 4377 CMe 0 QH' a bond Me a bond NH S a bond Q3a OH
4378 CMe 0 QIl' a bond Me a bond NH S a bond Q3d OH
4379 CMe 0 QH' a bond Me a bond NH S a bond Q3e OH
4380 CMe 0 QIl' a bond Me a bond NH S a bond Q3f OH
4381 CMe 0 QIl' a bond Me a bond NH S NH Q3a OH 4382 CMe 0 QIl' a bond Me a bond NH S NH Q3d OH
4383 CMe 0 QH' a bond Me a bond NH S NH Q3e OH
4384 CMe 0 QH' a bond Me a bond NH S NH Q3f OH
4385 CMe 0 QIm' a bond Me a bond NH O a bond Q3a OH
4386 CMe 0 QIm' a bond Me a bond NH O a bond Q3d OH 4387 CMe 0 QIm' a bond Me a bond NH O a bond Q3e OH
4388 CMe 0 QIm' a bond Me a bond NH O a bond Q3f OH
4389 CMe 0 QIm' a bond Me a bond NH 0 NH Q3a OH
4390 CMe 0 QIm' a bond Me a bond NH 0 NH Q3d OH
4391 CMe 0 QIm' a bond Me a bond NH 0 NH Q3e OH 4392 CMe 0 QIm' a bond Me a bond NH 0 NH Q3f OH
4393 CMe 0 QIm' a bond Me a bond NH S a bond Q3a OH
4394 CMe 0 QIm' a bond Me a bond NH S a bond Q3d OH
4395 CMe 0 QIm' a bond Me a bond NH S a bond Q3e OH
4396 CMe 0 QIm' a bond Me a bond NH S a bond Q3f OH 4397 CMe 0 QIm' a bond Me a bond NH S NH Q3a OH
4398 CMe 0 QIm' a bond Me a bond NH S NH Q3d OH 4399 CMe 0 QIm' a bond Me a bond NH S NH Q3e OH
4400 CMe 0 QIm' a bond Me a bond NH S NH Q3f OH
4401 CMe 0 QIn' a bond Me a bond NH 0 a bond Q3a OH
4402 CMe 0 QIn' a bond Me a bond NH 0 a bond Q3d OH
4403 CMe 0 QIn' a bond Me a bond NH 0 a bond Q3e OH
4404 CMe 0 QIn' a bond Me a bond NH 0 a bond Q3f OH
4405 CMe 0 QIn' a bond Me a bond NH 0 NH Q3a OH
4406 CMe 0 QIn' a bond Me a bond NH 0 NH Q3d OH
4407 CMe 0 QIn' a bond Me a bond NH 0 NH Q3e OH
4408 CMe 0 QIn' a bond Me a bond NH 0 NH Q3f OH
4409 CMe 0 QIn' a bond Me a bond NH S a bond Q3a OH
4410 CMe 0 QIn' a bond Me a bond NH S a bond Q3d OH
4411 CMe 0 QIn' a bond Me a bond NH S a bond Q3e OH
4412 CMe 0 QIn' a bond Me a bond NH S a bond Q3f OH
4413 CMe 0 QIn' a bond Me a bond NH S NH Q3a OH
4414 CMe 0 QIn' a bond Me a bond NH S NH Q3d OH
4415 CMe 0 QIn' a bond Me a bond NH S NH Q3e OH
4416 CMe 0 QIn' a bond Me a bond NH S NH Q3f OH
4417 N NMe QIa a bond Me a bond NH 0 a bond Q3d OH
4418 N NMe QIa a bond Me a bond NH 0 a bond Q3e OH
4419 N NMe QIa a bond Me a bond NH 0 a bond Q3f OH
4420 N NMe QIa a bond Me a bond NH 0 NH Q3d OH
4421 N NMe QIa a bond Me a bond NH 0 NH Q3e OH
4422 N NMe QIa a bond Me a bond NH 0 NH Q3f OH
4423 N NMe QIa a bond Me a bond NH S a bond Q3d OH
4424 N NMe QIa a bond Me a bond NH S a bond Q3e OH
4425 N NMe QIa a bond Me a bond NH S a bond Q3f OH
4426 N NMe QIa a bond Me a bond NH S NH Q3d OH
4427 N NMe QIa a bond Me a bond NH S NH Q3e OH
4428 N NMe QIa a bond Me a bond NH S NH Q3f OH
4429 N NMe QIb a bond Me a bond NH 0 a bond Q3d OH
4430 N NMe QIb a bond Me a bond NH 0 a bond Q3e OH
4431 N NMe QIb a bond Me a bond NH 0 a bond Q3f OH
4432 N NMe QIb a bond Me a bond NH 0 NH Q3d OH
4433 N NMe QIb a bond Me a bond NH 0 NH Q3e OH
4434 N NMe QIb a bond Me a bond NH 0 .NH Q3f OH 4435 N NMe QIb a bond Me a bond NH S a bond Q3d OH
4436 N NMe QIb a bond Me a bond NH S a bond Q3e OH
4437 N NMe QIb a bond Me a bond NH S a bond Q3f OH
4438 N NMe QIb a bond Me a bond NH S NH Q3d OH
4439 N NMe QIb a bond Me a bond NH S NH Q3e OH
4440 N NMe QIb a bond Me a bond NH S NH Q3f OH
4441 N NMe QIc a bond Me a bond NH 0 a bond Q3d OH
4442 N NMe QIc a bond Me a bond NH 0 a bond Q3e OH
4443 N NMe QIc a bond Me a bond NH 0 a bond Q3f OH
4444 N NMe QIc a bond Me a bond NH 0 NH Q3d OH
4445 N NMe QIc a bond Me a bond NH 0 NH Q3e OH
4446 N NMe QIc a bond Me a bond NH 0 NH Q3f OH
4447 N NMe QIc a bond Me a bond NH S a bond Q3d OH
4448 N NMe QIc a bond Me a bond NH S a bond Q3e OH
4449 N NMe QIc a bond Me a bond NH S a bond Q3f OH
4450 N NMe QIc a bond Me a bond NH S NH Q3d OH
4451 N NMe QIc a bond Me a bond NH S NH Q3e OH
4452 N NMe QIc a bond Me a bond NH S NH Q3f OH
4453 N NEt QIa a bond Me a bond NH 0 a bond Q3d OH
4454 N NEt QIa a bond Me a bond NH 0 a bond Q3e OH
4455 N NEt QIa a bond Me a bond NH 0 a bond Q3f OH
4456 N NEt QIa a bond Me a bond NH 0 NH Q3d OH
4457 N NEt QIa a bond Me a bond NH 0 NH Q3e OH
4458 N NEt QIa a bond Me a bond NH 0 NH Q3f OH
4459 N NEt QIa a bond Me a bond NH S a bond Q3d OH
4460 N NEt QIa a bond Me a bond NH S a bond Q3e OH
4461 N NEt QIa a bond Me a bond NH S a bond Q3f OH
4462 N NEt QIa a bond Me a bond NH S NH Q3d OH
4463 N NEt QIa a bond Me a bond NH S NH Q3e OH
4464 N NEt QIa a bond Me a bond NH S NH Q3f OH
4465 N NEt QIb a bond Me a bond NH 0 a bond Q3d OH
4466 N NEt QIb a bond Me a bond NH 0 a bond Q3e OH
4467 N NEt QIb a bond Me a bond NH 0 a bond Q3f OH
4468 N NEt QIb a bond Me a bond NH 0 NH Q3d OH
4469 N NEt QIb a bond Me a bond NH 0 NH Q3e OH
4470 N NEt QIb a bond Me a bond NH 0 NH Q3f OH 4471 N NEt QIb a bond Me a bond NH S a bond Q3d OH
4472 N NEt QIb a bond Me a bond NH S a bond Q3e OH
4473 N NEt QIb a bond Me a bond NH S a bond Q3f OH
4474 N NEt QIb a bond Me a bond NH S NH Q3d OH 4475 ' N NEt QIb a bond Me a bond NH S NH Q3e OH
4476 N NEt QIb a bond Me a bond NH S NH Q3f OH
4477 N NEt QIc a bond Me a bond NH 0 a bond Q3d OH
4478 N NEt QIc a bond Me a bond NH 0 a bond Q3e OH
4479 N NEt QIc a bond Me a bond NH 0 a bond Q3f OH 4480 N NEt QIc a bond Me a bond NH 0 NH Q3d OH
4481 N NEt QIc a bond Me a bond NH 0 NH Q3e OH
4482 N NEt QIc a bond Me a bond NH 0 NH Q3f OH
4483 N NEt QIc a bond Me a bond NH S a bond Q3d OH
4484 N NEt QIc a bond Me a bond NH S a bond Q3e OH 4485 N NEt QIc a bond Me a bond NH S a bond Q3f OH
4486 N NEt QIc a bond Me a bond NH S NH Q3d OH
4487 N NEt QIc a bond Me a bond NH S NH Q3e OH
4488 N NEt QIc a bond Me a bond NH S NH Q3f OH
4489 N S QIa a bond Me a bond NH 0 a bond Q3d OH 4490 N S QIa a bond Me a bond NH 0 a bond Q3e OH
4491 N S QIa a bond Me a bond NH 0 a bond Q3f OH
4492 N S QIa a bond Me a bond NH 0 NH Q3d OH
4493 N S QIa a bond Me a bond NH 0 NH Q3e OH
4494 N S QIa a bond Me a bond NH 0 NH Q3f OH 4495 N S QIa a bond Me a bond NH S a bond Q3d OH
4496 N S QIa a bond Me a bond NH S a bond Q3e OH
4497 N S QIa a bond Me a bond NH S a bond Q3f OH
4498 N S QIa a bond .Me a bond NH S NH Q3d OH
4499 N S QIa a bond Me a bond NH S NH Q3e OH 4500 N S QIa a bond Me a bond NH S NH Q3f OH
4501 N S QIb a bond Me a bond NH 0 a bond Q3d OH
4502 N S QIb a bond Me a bond NH 0 a bond Q3e OH
4503 N S QIb a bond Me a bond NH 0 a bond Q3f OH
4504 N S QIb a bond Me a bond NH 0 NH Q3d OH 4505 N S QIb a bond Me a bond NH 0 NH Q3e OH
4506 N S QIb a bond Me a bond NH 0 -NH Q3f OH 4507 N S QIb a bond Me a bond NH S a bond Q3d OH
4508 N S QIb a bond Me a bond NH S a bond Q3e OH
4509 N S QIb a bond Me a bond NH S a bond Q3f OH
4510 N S QIb a bond Me a bond NH S NH Q3d OH
4511 N S QIb a bond Me a bond NH S NH Q3e OH
4512 N S QIb a bond Me a bond NH S NH Q3f OH
4513 N S QIc a bond Me a bond NH 0 a bond Q3d OH
4514 N S QIc a bond Me a bond NH 0 a bond Q3e OH
4515 N S QIc a bond Me a bond NH 0 a bond Q3f OH
4516 N S QIc a bond Me a bond NH 0 NH Q3d OH
4517 N S QIc a bond Me a bond NH 0 NH Q3e OH
4518 N S QIc a bond Me a bond NH 0 NH Q3f OH
4519 N S QIc a bond Me a bond NH S a bond Q3d OH
4520 N S QIc a bond Me a bond NH S a bond Q3e OH
4521 N S QIc a bond Me a bond NH S a bond Q3f OH
4522 N S QIc a bond Me a bond NH S NH Q3d OH
4523 N S QIc a bond Me a bond NH S NH Q3e OH
4524 N S QIc a bond Me a bond NH S NH Q3f OH
4525 N 0 QIa a bond Me a bond NH 0 a bond Q3d OH
4526 N 0 QIa a bond Me a bond NH 0 a bond Q3e OH
4527 N 0 QIa a bond Me a bond NH 0 a bond Q3f OH
4528 N 0 QIa a bond Me a bond NH 0 NH Q3d OH
4529 N 0 QIa a bond Me a bond NH 0 NH Q3e OH
4530 N 0 QIa a bond Me a bond NH 0 NH Q3f OH
4531 N 0 QIa a bond Me a bond NH S a bond Q3d OH
4532 N 0 QIa a bond Me a bond NH S a bond Q3e OH
4533 N 0 QIa a bond Me a bond NH S a bond Q3f OH
4534 N 0 QIa a bond Me a bond NH S NH Q3d OH
4535 N 0 QIa a bond Me a bond NH S NH Q3e OH
4536 N 0 QIa a bond Me a bond NH S NH Q3f OH
4537 N 0 QIb a bond Me a . bond NH 0 a bond Q3d OH
4538 N 0 QIb a bond Me a bond NH 0 a bond Q3e OH
4539 N 0 QIb a bond Me a bond NH ϋ a bond Q3f OH
4540 N 0 QIb a bond Me a bond NH 0 NH Q3d OH
4541 N 0 QIb a bond Me a bond NH 0 NH Q3e OH
4542 N 0 QIb a bond Me a bond NH 0 NH Q3f OH 4543 N 0 QIb a bond Me a bond NH S a bond Q3d OH
4544 N 0 QIb a bond Me a bond NH S a bond Q3e OH
4545 N 0 QIb a bond Me a bond NH S a bond Q3f OH
4546 N 0 QIb a bond Me a bond NH S NH Q3d OH
4547 N 0 QIb a bond Me a bond NH S NH Q3e OH
4548 N 0 QIb a bond Me a bond NH S NH Q3f OH
4549 N 0 QIc a bond Me a bond NH 0 a bond Q3d OH
4550 N 0 QIc a bond Me a bond NH 0 a bond Q3e OH
4551 N 0 QIc a bond Me a bond NH 0 a bond Q3f OH
4552 N 0 QIc a bond Me a bond NH 0 NH Q3d OH
4553 N 0 QIc a bond Me a bond NH 0 NH Q3e OH
4554 N 0 QIc a bond Me a bond NH 0 NH Q3f OH
4555 N 0 QIc a bond Me a bond NH S a bond Q3d OH
4556 N 0 QIc a bond Me a bond NH S a bond Q3e OH
4557 N 0 QIc a bond Me a bond NH S a bond Q3f OH
4558 N 0 QIc a bond Me a bond NH S NH Q3d OH
4559 N 0 QIc a bond Me a bond NH S NH Q3e OH
4560 N 0 QIc a bond Me a bond NH S NH Q3f OH
4561 CH NMe QIa a bond Me a bond NH 0 a bond Q3d OH
4562 CH NMe QIa a bond Me a bond NH 0 a bond Q3e OH
4563 CH NMe QIa a bond Me a bond NH 0 a bond Q3f OH
4564 CH NMe QIa a bond Me a bond NH 0 NH Q3d OH
4565 CH NMe QIa a bond Me a bond NH 0 NH Q3e OH
4566 CH NMe QIa a bond Me a bond NH 0 NH Q3f OH
4567 CH NMe QIa a bond Me a bond NH S a bond Q3d OH
4568 CH NMe QIa a bond Me a bond NH S a bond Q3e OH
4569 CH NMe QIa a bond Me a bond NH S a bond Q3f OH
4570 CH NMe QIa a bond Me a bond NH S NH Q3d OH
4571 CH NMe QIa a bond Me a bond NH S NH Q3e OH
4572 CH NMe QIa a bond Me a bond NH S NH Q3f OH
4573 CH NMe QIb a bond Me a bond NH 0 a bond Q3d OH
4574 CH NMe QIb a bond Me a bond NH 0 a bond Q3e OH
4575 CH NMe QIb a bond Me a bond NH 0 a bond Q3f OH
4576 CH NMe QIb a bond Me a bond NH 0 NH Q3d OH
4577 CH NMe QIb a bond Me a bond NH 0 NH Q3e OH
4578 CH NMe QIb a bond Me a bond NH 0 NH Q3f OH 4579 CH NMe QIb a bond Me a bond NH S a bond Q3d OH
4580 CH NMe QIb a bond Me a bond NH S a bond Q3e OH
4581 CH NMe QIb bond Me a bond NH S a bond Q3f OH
4582 CH NMe QIb bond Me a bond NH S NH Q3d OH
4583 CH NMe QIb bond Me a bond NH S NH Q3e OH
4584 CH NMe QIb a bond Me a bond NH S NH Q3f OH
4585 CH NMe QIc a bond Me a bond NH 0 a bond Q3d OH
4586 CH NMe QIc a bond Me a bond NH 0 a bond Q3e OH
4587 CH NMe QIc a bond Me a bond NH 0 a bond Q3f OH
4588 CH NMe QIc a bond Me a bond NH 0 NH Q3d OH
4589 CH NMe QIc a bond Me a bond NH 0 NH Q3e OH
4590 CH NMe QIc a bond Me a bond NH 0 NH Q3f OH
4591 CH NMe QIc a bond Me a bond NH S a bond Q3d OH
4592 CH NMe QIc a bond Me a bond NH S a bond Q3e OH
4593 CH NMe QIc a bond Me a bond NH S a bond Q3f OH
4594 CH NMe QIc a bond Me a bond NH S NH Q3d OH
4595 CH NMe QIc a bond Me a bond NH S NH Q3e OH
4596 CH NMe QIc a bond Me a bond NH S NH Q3f OH
4597 CH NEt QIa a bond Me a bond NH 0 a bond Q3d OH
4598 CH NEt QIa a bond Me a bond NH 0 a bond Q3e OH
4599 CH NEt QIa a bond Me a bond NH 0 a bond Q3f OH
4600 CH NEt QIa a bond Me a bond NH 0 NH Q3d OH
4601 CH NEt QIa a bond Me a bond NH 0 NH Q3e OH
4602 CH NEt QIa a bond Me a bond NH 0 NH Q3f OH
4603 CH NEt QIa a bond Me a -bond NH S a bond Q3d OH
4604 CH NEt QIa a bond Me a bond NH S a bond Q3e OH
4605 CH NEt QIa a bond Me a bond NH S a bond Q3f OH
4606 CH NEt QIa a bond Me a bond NH S NH Q3d OH
4607 CH NEt QIa a bond Me a bond NH S NH Q3e OH
4608 CH NEt QIa a bond Me a bond NH S NH Q3f OH
4609 CH NEt QIb a bond Me a bond NH 0 a bond Q3d OH
4610 CH NEt QIb a bond Me a bond NH 0 a bond Q3e OH
4611 CH NEt QIb a bond Me a bond NH 0 a bond Q3f OH
4612 CH NEt QIb a bond Me a bond NH 0 NH Q3d OH
4613 CH NEt QIb a bond Me a bond NH 0 NH Q3e OH
4614 CH NEt QIb a bond Me a bond NH 0 NH Q3f OH 4615 CH NEt QIb a bond Me a bond NH S a bond Q3d OH
4616 CH NEt QIb a bond Me a bond NH S a bond Q3e OH
4617 CH NEt QIb a bond Me a bond NH S a bond Q3f OH
4618 CH NEt QIb a bond Me a bond NH S NH Q3d OH
4619 CH NEt QIb a bond Me a bond NH S NH Q3e OH
4620 CH NEt QIb a bond Me a bond NH S NH Q3f OH
4621 CH NEt QIc a bond Me a bond NH 0 a bond Q3d OH
4622 CH NEt QIc a bond Me a bond NH 0 a bond Q3e OH
4623 CH NEt QIc a bond Me a bond NH 0 a bond Q3f OH
4624 CH NEt QIc a bond Me a bond NH 0 NH Q3d OH
4625 CH NEt QIc a bond Me a bond NH 0 NH Q3e OH
4626 CH NEt QIc a bond Me a bond NH 0 NH Q3f OH
4627 CH NEt QIc a bond Me a bond NH S a bond Q3d OH
4628 CH NEt QIc a bond Me a bond NH S a bond Q3e OH
4629 CH NEt QIc a bond Me a bond NH S a bond Q3f OH
4630 CH NEt QIc a bond Me a bond NH S NH Q3d OH
4631 CH NEt QIc a bond Me a bond NH S NH Q3e OH
4632 CH NEt QIc a bond Me a bond NH S NH Q3f OH
4633 CH S QIa a bond Me a bond NH 0 a bond Q3d OH
4634 CH S QIa a bond Me a bond NH 0 a bond Q3e OH
4635 CH S QIa a bond Me a bond NH 0 a bond Q3f OH
4636 CH S QIa a bond Me a bond NH 0 NH Q3d OH
4637 CH S QIa a bond Me a bond NH 0 NH Q3e OH
4638 CH S QIa a bond Me a bond NH 0 NH Q3f OH
4639 CH S QIa a bond Me a bond NH S a bond Q3d OH
4640 CH S QIa a bond Me a bond NH S a bond Q3e OH
4641 CH S QIa a bond Me a bond NH S a bond Q3f OH
4642 CH S QIa a bond Me a bond NH S NH Q3d OH
4643 CH S QIa a bond Me a bond NH S NH Q3e OH
4644 CH S QIa a bond Me a bond NH S NH Q3f OH
4645 CH S QIb a bond Me a bond NH 0 a bond Q3d OH
4646 CH S QIb a bond Me a bond NH 0 a bond Q3e OH
4647 CH S QIb a bond Me a bond NH 0 a bond Q3f OH
4648 CH S QIb a bond Me a bond NH 0 NH Q3d OH
4649 CH S QIb a bond Me a bond NH 0 NH Q3e OH
4650 CH S QIb a bond Me a bond NH 0 NH Q3f OH 4651 CH S QIb a bond Me a bond NH S a bond Q3d OH
4652 CH S QIb a bond Me a bond NH S a bond Q3e OH
4653 CH S QIb a bond Me a bond NHi S a bond Q3f OH
4654 CH S QIb a bond Me a bond NH S NH Q3d OH
4655 CH S QIb a bond Me a bond NH S NH Q3e OH
4656 CH S QIb a bond Me a bond NH S Q3f OH
4657 CH S QIc a bond Me a bond NH 0 a bond Q3d OH
4658 CH S QIc a bond Me a bond NH 0 a bond Q3e OH
4659 CH S QIc a bond Me a bond NH 0 a bond Q3f OH
4660 CH S QIc a bond Me a bond NH 0 NH Q3d OH
4661 CH S QIc a bond Me a bond NH 0 NH Q3e OH
4662 CH S QIc a bond Me a bond NH 0 NH Q3f OH
4663 CH S QIc a bond Me a bond NH S a bond Q3d OH
4664 CH S QIc a bond Me a bond NH S a bond Q3e OH
4665 CH S QIc a bond Me a bond NH S a bond Q3f OH
4666 CH S QIc a bond Me a bond NH S NH Q3d OH
4667 CH S QIc a bond Me a bond NH S NH Q3e OH
4668 CH S QIc a bond Me a bond NH S NH Q3f OH
4669 CH 0 QIa a bond Me a bond NH 0 a bond Q3d OH
4670 CH 0 QIa a bond Me a bond NH 0 a bond Q3e OH
4671 CH 0 QIa a bond Me a bond NH 0 a bond Q3f OH
4672 CH 0 QIa a bond Me a bond NH 0 NH Q3d OH
4673 CH 0 QIa a bond Me a bond NH 0 NH Q3e OH
4674 CH 0 QIa a bond Me a bond NH 0 NH Q3f OH
4675 CH 0 QIa a bond Me a bond NH S a bond Q3d OH
4676 CH 0 QIa a bond Me a bond NH S a bond Q3e OH
4677 CH 0 QIa a bond Me a bond NH S a bond Q3f OH
4678 CH 0 QIa a bond Me a bond NH S NH Q3d OH
4679 CH 0 QIa a bond Me a bond NH S NH Q3e OH
4680 CH 0 QIa a bond Me a bond NH S NH Q3f OH
4681 CH 0 QIb a bond Me a bond NH 0 a bond Q3d OH
4682 CH 0 QIb a bond Me a bond NH 0 a bond Q3e OH
4683 CH 0 QIb a bond Me a bond NH 0 a bond Q3f OH
4684 CH 0 QIb a bond Me a bond NH 0 NH Q3d OH
4685 CH 0 QIb a bond Me a bond NH 0 NH Q3e OH
4686 CH 0 QIb a bond Me a bond NH 0 NH Q3f OH 4687 CH 0 QIb a bond Me a bond NH S a bond Q3d OH
4688 CH 0 QIb a bond Me a bond NH S a bond Q3e OH
4689 CH 0 QIb a bond Me a bond NH S a bond Q3f OH
4690 CH 0 QIb a bond Me a bond NH S NH Q3d OH
4691 CH 0 QIb a bond Me a bond NH S NH Q3e OH
4692 CH 0 QIb a bond Me a bond NH S NH Q3f OH
4693 CH 0 QIc a bond Me a bond NH 0 a bond Q3d OH
4694 CH 0 QIc a bond Me a bond NH 0 a bond Q3e OH
4695 CH 0 QIc a bond Me a bond NH 0 a bond Q3f OH
4696 CH 0 QIc a bond Me a bond NH 0 NH Q3d OH
4697 CH 0 QIc a bond Me a bond NH 0 NH Q3e OH
4698 CH 0 QIc a bond Me a bond NH 0 NH Q3f OH
4699 CH 0 QIc a bond Me a bond NH S a bond Q3d OH
4700 CH 0 QIc a bond Me a bond NH S a bond Q3e OH
4701 CH 0 QIc a bond Me a bond NH S a bond Q3f OH
4702 CH 0 QIc a bond Me a bond NH S NH Q3d OH
4703 CH 0 QIc a bond Me a bond NH S NH Q3e OH
4704 CH 0 QIc a bond Me a bond NH S NH Q3f OH
4705 CMe NMe QIa a bond Me a bond NH 0 a bond Q3d OH
4706 CMe NMe QIa a bond Me a bond NH 0 a bond Q3e OH
4707 CMe NMe QIa a bond Me a bond NH 0 a bond Q3f OH
4708 CMe NMe QIa a bond Me a bond NH 0 NH Q3d OH
4709 CMe NMe QIa a bond Me a bond NH 0 NH Q3e OH
4710 CMe NMe QIa a bond Me a bond NH 0 NH Q3f OH
4711 CMe NMe QIa a bond Me a bond NH S a bond Q3d OH
4712 CMe NMe QIa a bond Me a bond NH S a bond Q3e OH
4713 CMe NMe QIa a bond Me a bond NH S a bond Q3f OH
4714 CMe NMe QIa a bond Me a bond NH S NH Q3d OH
4715 CMe NMe QIa a bond Me a bond NH S NH Q3e OH
4716 CMe NMe QIa a bond Me a bond NH S NH Q3f OH
4717 CMe NMe QIb a bond Me a bond NH 0 a bond Q3d OH
4718 CMe NMe QIb a bond Me a bond NH 0 a bond Q3e OH
4719 CMe NMe QIb a bond Me a bond NH 0 a bond Q3f OH
4720 CMe NMe QIb a bond Me a bond NH 0 NH Q3d OH
4721 CMe NMe QIb a bond Me a bond NH 0 NH Q3e OH
4722 CMe NMe QIb a bond Me a bond NH 0 NH Q3f OH 4723 CMe NMe QIb a bond Me a bond NH S a bond Q3d OH
4724 CMe NMe QIb a bond Me a bond NH S a bond Q3e OH
4725 CMe NMe QIb a bond Me a bond NH S a bond Q3f OH
4726 CMe NMe QIb a bond Me a bond NH S NH Q3d OH
4727 CMe NMe QIb a bond Me a bond NH S NH Q3e OH
4728 CMe NMe QIb a bond Me a bond NH S NH Q3f OH
4729 CMe NMe QIc a bond Me a bond NH 0 a bond Q3d OH
4730 CMe NMe QIc a bond Me a bond NH 0 a bond Q3e OH
4731 CMe NMe QIc a bond Me a bond NH 0 a bond Q3f OH
4732 CMe NMe QIc a bond Me a bond NH 0 NH Q3d OH
4733 CMe NMe QIc a bond Me a bond NH 0 NH Q3e OH
4734 CMe NMe QIc a bond Me a bond NH 0 NH Q3f OH
4735 CMe NMe QIc a bond Me a bond NH S a bond Q3d OH
4736 CMe NMe QIc a bond Me a bond NH S a bond Q3e OH
4737 CMe NMe QIc a bond Me a bond NH S a bond Q3f OH
4738 CMe NMe QIc a bond Me a bond NH S NH Q3d OH
4739 CMe NMe QIc a bond Me a bond NH S NH Q3e OH
4740 CMe NMe QIc a bond Me a bond NH S NH Q3f OH
4741 CMe NEt QIa a bond Me a bond NH 0 a bond Q3d OH
4742 CMe NEt QIa a bond Me a bond NH 0 a bond Q3e OH
4743 CMe NEt QIa a bond Me a bond NH 0 a bond Q3f OH
4744 CMe NEt QIa a bond Me a bond NH 0 NH Q3d OH
4745 CMe NEt QIa a bond Me a bond NH 0 NH Q3e OH
4746 CMe NEt QIa a bond Me a bond NH 0 NH Q3f OH
4747 CMe NEt QIa a bond Me a bond NH S a bond Q3d OH
4748 CMe NEt QIa a bond Me a bond NH S a bond Q3e OH
4749 CMe NEt QIa a bond Me a bond NH S a bond Q3f OH
4750 CMe NEt QIa a bond Me a bond NH S NH Q3d OH
4751 CMe NEt QIa a bond Me a bond NH S NH Q3e OH
4752 CMe NEt QIa a bond Me a bond NH S NH Q3f OH
4753 CMe NEt QIb a bond Me a bond NH 0 a bond Q3d OH
4754 CMe NEt QIb a bond Me a bond NH 0 a bond Q3e OH
4755 CMe NEt QIb a bond Me a bond NH 0 a bond Q3f OH
4756 CMe NEt QIb a bond Me a bond NH 0 NH Q3d OH
4757 CMe NEt QIb a bond Me a bond NH 0 NH Q3e OH
4758 CMe NEt QIb a bond Me a bond NH 0 NH Q3f OH 4759 CMe NEt QIb a bond Me a bond NH S a bond Q3d OH
4760 CMe NEt QIb a bond Me a bond NH S a bond Q3e OH
4761 CMe NEt QIb a bond Me a bond NH S a bond Q3f OH
4762 CMe NEt QIb a bond Me a bond NH S NH Q3d OH
4763 CMe NEt QIb • a bond Me a bond NH S NH Q3e OH
4764 CMe NEt QIb a bond Me a bond NH S NH Q3f OH
4765 CMe NEt QIc a bond Me a bond NH 0 a bond Q3d OH
4766 CMe NEt QIc a bond Me a bond NH 0 a bond Q3e OH
4767 CMe NEt QIc a bond Me a bond NH 0 a bond Q3f OH
4768 CMe NEt QIc a bond Me a bond NH 0 NH Q3d OH
4769 CMe NEt QIc a bond Me a bond NH 0 NH Q3e OH
4770 CMe NEt QIc a bond Me a bond NH 0 NH Q3f OH
4771 CMe NEt QIc a bond Me a bond NH S a bond Q3d OH
4772 CMe NEt QIc a bond Me a bond NH S a bond Q3e OH
4773 CMe NEt QIc a bond Me a bond NH S a bond Q3f OH
4774 CMe NEt QIc a bond Me a bond NH S NH Q3d OH
4775 CMe NEt QIc a bond Me a bond NH S NH Q3e OH
4776 CMe NEt QIc a bond Me a bond NH S NH Q3f OH
4777 CMe S QIa a bond Me a bond NH 0 a bond Q3d OH
4778 CMe S QIa a bond Me a bond NH 0 a bond Q3e OH
4779 CMe S QIa a bond Me a bond NH 0 a bond Q3f OH
4780 CMe S QIa a bond Me a bond NH 0 NH Q3d OH
4781 CMe S QIa a bond Me a bond NH 0 NH Q3e OH
4782 CMe S QIa a bond Me a bond NH 0 NH Q3f OH
4783 CMe S QIa a bond Me a bond NH S a bond Q3d OH
4784 CMe S QIa a bond Me a bond NH S a bond Q3e OH
4785 CMe S QIa a bond Me a bond NH S a bond Q3f OH
4786 CMe S QIa a bond Me a bond NH S NH Q3d OH
4787 CMe S QIa a bond Me a bond NH S NH Q3e OH
4788 CMe S QIa a bond Me a bond NH S NH Q3f OH
4789 CMe S QIb a bond Me a bond NH 0 a bond Q3d OH
4790 CMe S QIb a bond Me a bond NH 0 a bond Q3e OH
4791 CMe S QIb a bond Me a bond NH 0 a bond Q3f OH
4792 CMe S QIb a bond Me a bond NH 0 NH Q3d OH
4793 CMe S QIb a bond Me a bond NH 0 NH Q3e OH
4794 CMe S QIb a bond Me a bond NH 0 NH Q3f OH 4795 CMe S QIb a bond Me a bond NH S a bond Q3d OH
4796 CMe S QIb a bond Me a bond NH S a bond Q3e OH
4797 CMe S QIb a bond Me a bond NH S a bond Q3f OH
4798 CMe S QIb a bond Me a bond NH S NH Q3d OH
4799 CMe S QIb a bond Me a bond NH S NH Q3e OH
4800 CMe S QIb a bond Me a bond NH S NH Q3f OH
4801 CMe S QIc a bond Me a bond NH 0 a bond Q3d OH
4802 CMe S QIc a bond Me a bond NH 0 a bond Q3e OH
4803 CMe S QIc a bond Me a bond NH 0 a bond Q3f OH
4804 CMe S QIc a bond Me a bond NH 0 NH Q3d OH
4805 CMe S QIc a bond Me a bond NH 0 NH Q3e OH
4806 CMe S QIc a bond Me a bond NH 0 NH Q3f OH
4807 CMe S QIc a bond Me a bond NH S a bond Q3d OH
4808 CMe S QIc a bond Me a bond NH S a bond Q3e OH
4809 CMe S QIc a bond Me a bond NH S a bond Q3f OH
4810 CMe S QIc a bond Me a bond NH S NH Q3d OH
4811 CMe S QIc a bond Me a bond NH S NH Q3e OH
4812 CMe S QIc a bond Me a bond NH S NH Q3f OH
4813 CMe 0 QIa a bond Me a bond NH 0 a bond Q3d OH
4814 CMe 0 QIa a bond Me a bond NH 0 a bond Q3e OH
4815 CMe 0 QIa a bond Me a bond NH 0 a bond Q3f OH
4816 CMe 0 QIa a bond Me a bond NH 0 NH Q3d OH
4817 CMe 0 QIa a bond Me a bond NH 0 NH Q3e OH
4818 CMe 0 QIa a bond Me a bond NH 0 NH Q3f OH
4819 CMe 0 QIa a bond Me a bond NH S a bond Q3d OH
4820 CMe 0 QIa a bond ■ Me a bond NH S a bond Q3e OH
4821 CMe 0 QIa a bond Me a bond NH S a bond Q3f OH
4822 CMe 0 QIa a bond Me a bond NH S NH Q3d OH
4823 CMe 0 QIa a bond Me a bond NH S NH Q3e OH
4824 CMe 0 QIa a bond Me a bond NH S NH Q3f OH
4825 CMe 0 QIb a bond Me a bond NH 0 a bond Q3d OH
4826 CMe 0 QIb a bond Me a bond NH 0 a bond Q3e OH
4827 CMe 0 QIb a bond Me a bond NH 0 a bond Q3f OH
4828 CMe 0 QIb a bond Me a bond NH 0 NH Q3d OH
4829 CMe 0 QIb a bond Me a bond NH 0 NH Q3e OH
4830 CMe 0 QIb a bond Me a bond NH 0 .NH Q3f OH 4831 CMe 0 QIb a bond Me a bond NH S a bond Q3d OH
4832 CMe 0 QIb a bond Me a bond NH S a bond Q3e OH
4833 CMe 0 QIb a bond Me a bond NH S a bond Q3f OH
4834 CMe 0 QIb a bond Me a bond NH S NH Q3d OH
4835 CMe 0 QIb a bond Me a bond NH S NH Q3e OH
4836 CMe 0 QIb a bond Me a bond NH S NH Q3f OH
4837 CMe 0 QIc a bond Me a bond NH 0 a bond Q3d OH
4838 CMe 0 QIc a bond Me a bond NH 0 a bond Q3e OH
4839 CMe 0 QIc a bond Me a bond NH 0 a bond Q3f OH
4840 CMe 0 QIc a bond Me a bond NH 0 NH Q3d OH
4841 CMe 0 QIc a bond Me a bond NH 0 NH Q3e OH
4842 CMe 0 QIc a bond Me a bond NH 0 NH Q3f OH
4843 CMe 0 QIc a bond Me a bond NH S a bond Q3d OH
4844 CMe 0 QIc a bond Me a bond NH S a bond Q3e OH
4845 CMe 0 QIc a bond Me a bond NH S a bond Q3f OH
4846 CMe 0 QIc a bond Me a bond NH S NH Q3d OH
4847 CMe 0 QIc a bond Me a bond NH S NH Q3e OH
4848 CMe 0 QIc a bond Me a bond NH S NH Q3f OH
4849 N NMe QIa a bond Me a bond NH S NH Q3g OH
4850 N NMe QIa a bond Me a bond NH S NH Q3h OH
4851 N NMe QIb a bond Me a bond NH S NH Q3g OH
4852 N NMe QIb a bond Me a bond NH S NH Q3h OH
4853 N NMe QIc a bond Me a bond NH S NH Q3g OH
4854 N NMe QIc a bond Me a bond NH S NH Q3h OH
4855 N NEt QIa a bond Me a bond NH S NH Q3g OH
4856 N NEt QIa a bond Me a bond NH S NH Q3h OH
4857 N NEt QIb a bond Me a bond NH S NH Q3g OH
4858 N NEt QIb a bond Me a bond NH S NH Q3h OH
4859 N NEt QIc a bond Me a bond NH S NH Q3g OH
4860 N NEt QIc a bond Me a bond NH S NH Q3h OH
4861 N S QIa a bond Me a bond NH S NH Q3g OH
4862 N S QIa a bond Me a bond NH S NH Q3h OH
4863 N S QIb a bond Me a bond NH S NH Q3g OH
4864 N S QIb a bond Me a bond NH S NH Q3h OH
4865 N S QIc a bond Me a bond NH S NH Q3g OH
4866 N S QIc a bond Me a bond NH S NH Q3h OH 4867 N 0 QIa a bond Me a bond NH S NH Q3g OH
4868 N 0 QIa a bond Me a bond NH S NH Q3h OH
4869 N 0 QIb a bond Me a bond NH S NH Q3g OH
4870 N 0 QIb a bond Me a bond NH S NH Q3h OH
4871 N 0 QIc a bond Me a bond NH S NH Q3g OH
4872 N 0 QIc a bond Me a bond NH S NH Q3h OH
4873 CH NMe QIa a bond Me a bond NH S NH Q3g OH
4874 CH NMe QIa a bond Me a bond NH S NH Q3h OH
4875 CH NMe QIb a bond Me a bond NH S NH Q3g OH
4876 CH NMe QIb a bond Me a bond NH S NH Q3h OH
4877 CH NMe QIc a bond Me a bond NH S NH Q3g OH
4878 CH NMe QIc a bond Me a bond NH S NH Q3h OH
4879 CH NEt QIa a bond Me a bond NH S NH Q3g OH
4880 CH NEt QIa a bond Me a bond NH S NH Q3h OH
4881 CH NEt QIb a bond Me a bond NH S NH Q3g OH
4882 CH NEt QIb a bond Me a bond NH S NH Q3h OH
4883 CH NEt QIc a bond Me a bond NH S NH Q3g OH
4884 CH NEt QIc a bond Me a bond NH S NH Q3h OH
4885 CH S QIa a' bond Me a bond NH S NH Q3g OH
4886 CH S QIa a bond Me a bond NH S NH Q3h OH
4887 CH S QIb a bond Me a bond NH S NH Q3g OH
4888 CH S QIb a bond Me a bond NH S NH Q3h OH
4889 CH S QIc a bond Me a bond NH S NH Q3g OH
4890 CH S QIc a bond Me a bond NH S NH Q3h OH
4891 CH 0 QIa a bond Me a bond NH S NH Q3g OH
4892 CH 0 QIa a bond Me a bond NH S NH Q3h OH
4893 CH 0 QIb a bond Me a bond NH S NH Q3g OH
4894 CH 0 QIb a bond Me. a bond NH S NH Q3h OH
4895 CH 0 QIc a bond Me a bond NH S NH Q3g OH
4896 CH 0 QIc a bond Me a bond NH S NH Q3h OH
4897 CMe NMe QIa a bond Me a bond NH S NH Q3g OH
4898 CMe NMe QIa a bond Me a bond NH S NH Q3h OH
4899 CMe NMe QIb a bond Me a bond NH S NH Q3g OH
4900 CMe NMe QIb a bond Me a bond NH S NH Q3h OH
4901 CMe NMe QIc a bond Me a bond NH S NH Q3g OH
4902 CMe NMe QIc a bond Me a bond NH S .NH Q3h OH 4903 CMe NEt QIa a bond Me a bond NH S NH Q3g OH
4904 CMe NEt QIa a bond Me a bond NH S NH Q3h OH
4905 CMe NEt QIb a bond Me a bond NH S NH Q3g OH
4906 CMe NEt QIb a bond Me a bond NH S NH Q3h OH
4907 CMe NEt QIc a bond Me a bond NH S NH Q3g OH
4908 CMe NEt QIc a bond Me a bond NH S NH Q3h OH
4909 CMe S QIa a bond Me a bond NH S NH Q3g OH
4910 CMe S QIa a bond Me a bond NH S NH Q3h OH
4911 CMe S QIb a bond Me a bond NH S NH Q3g OH
4912 CMe S QIb a bond Me a bond NH S NH Q3h OH
4913 CMe S QIc a bond Me a bond NH S NH Q3g OH
4914 CMe S QIc a bond Me a bond NH S NH Q3h OH
4915 CMe 0 QIa a bond Me a bond NH S NH Q3g OH
4916 CMe 0 QIa a bond Me a bond NH S NH Q3h OH
4917 CMe 0 QIb a bond Me a bond NH S NH Q3g OH
4918 CMe 0 QIb a bond Me a bond NH S NH Q3h OH
4919 CMe 0 QIc a bond Me a bond NH S NH Q3g OH
4920 CMe 0 QIc a bond Me a bond NH S NH Q3h OH
4921 N NMe QIa a bond Me a bond NH 0 a bond Q3g OH
4922 N NMe QIa a bond Me a bond NH 0 a bond Q3h OH
4923 N NMe QIb a bond Me a bond NH 0 a bond Q3g OH
4924 N NMe QIb a bond Me a bond NH 0 a bond Q3h OH
4925 N NMe QIc a bond Me a bond NH 0 a bond Q3g OH
4926 N NMe QIc a bond Me a bond NH 0 a bond Q3h OH
4927 N NEt QIa a bond Me a bond NH 0 a bond Q3g OH
4928 N NEt QIa a bond Me a bond NH 0 a bond Q3h OH
4929 N NEt QIb a bond Me a bond NH 0 a bond Q3g OH
4930 N NEt QIb a bond Me a bond NH 0 a bond Q3h OH
4931 N NEt QIc a bond Me a bond NH 0 a bond Q3g OH
4932 N NEt QIc a bond Me a bond NH 0 a bond Q3h OH
4933 N S QIa a bond Me a bond NH 0 a bond Q3g OH
4934 N S QIa a bond Me a bond NH 0 a bond Q3h OH
4935 N S QIb a bond Me a bond NH 0 a bond Q3g OH
4936 N S QIb a bond Me a bond NH 0 a bond Q3h OH
4937 N S QIc a bond Me a bond NH 0 a bond Q3g OH
4938 N S QIc a bond Me a bond NH 0 a bond Q3h OH 4939 N 0 QIa a bond Me a bond NH 0 a bond Q3g OH
4940 N 0 QIa a bond Me a bond NH 0 a bond Q3h OH
4941 N 0 QIb a bond Me a bond NH 0 a bond Q3g OH
4942 N 0 QIb a bond Me a bond NH 0 a bond Q3h OH
4943 N 0 QIc a bond Me a bond NH 0 a bond Q3g OH
4944 N 0 QIc a bond Me a bond NH 0 a bond Q3h OH
4945 CH NMe QIa a bond Me a bond NH 0 a bond Q3g OH
4946 CH NMe QIa a bond Me a bond NH 0 a bond Q3h OH
4947 CH NMe QIb a bond Me a bond NH 0 a bond Q3g OH
4948 CH NMe QIb a bond Me a bond NH 0 a bond Q3h OH
4949 CH NMe QIc a bond Me a bond NH 0 a bond Q3g OH
4950 CH NMe QIc a bond Me a bond NH 0 a bond Q3h OH
4951 CH NEt QIa a bond Me a bond NH 0 a bond Q3g OH
4952 CH NEt QIa a bond Me a bond NH 0 a bond Q3h OH
4953 CH NEt QIb a bond Me a bond NH 0 a bond Q3g OH
4954 CH NEt QIb a bond Me a bond NH 0 a bond Q3h OH
4955 CH NEt QIc a bond Me a bond NH 0 a bond Q3g OH
4956 CH NEt QIc a bond Me a bond NH 0 a bond Q3h OH
4957 CH S QIa a bond Me a bond NH 0 a bond Q3g OH
4958 CH S QIa a bond Me a bond NH 0 a bond Q3h OH
4959 CH S QIb a bond Me a bond NH 0 a bond Q3g OH
4960 CH S QIb a bond Me a bond NH 0 a bond Q3h OH
4961 CH S QIc a bond Me a bond NH 0 a bond Q3g OH
4962 CH S QIc a bond Me a bond NH 0 a bond Q3h OH
4963 CH 0 QIa a bond Me a bond NH 0 a bond Q3g OH
4964 CH 0 QIa a bond Me a bond NH 0 a bond Q3h OH
4965 CH 0 QIb a bond Me a bond NH 0 a bond Q3g OH
4966 CH 0 QIb a bond Me a bond NH 0 a bond Q3h OH
4967 CH 0 QIc a bond Me a bond NH 0 a bond Q3g OH
4968 CH 0 QIc a bond Me a bond NH 0 a bond Q3h OH
4969 CMe NMe QIa a bond Me a bond NH 0 a bond Q3g OH
4970 CMe NMe QIa a bond Me a bond NH 0 a bond Q3h OH
4971 CMe NMe QIb a bond Me a bond NH 0 a bond Q3g OH
4972 CMe NMe QIb a bond Me a bond NH 0 a bond Q3h OH
4973 CMe NMe QIc a bond Me a bond NH 0 a bond Q3g OH
4974 CMe NMe QIc a bond Me a bond NH 0 a. bond Q3h OH 4975 CMe NEt QIa a bond Me a bond NH 0 a bond Q3g OH
4976 CMe NEt QIa a bond Me a bond NH 0 a bond Q3h OH
4977 CMe NEt QIb a bond Me a bond NH 0 a bond Q3g OH
4978 CMe NEt QIb a bond Me a bond NH 0 a bond Q3h OH
4979 CMe NEt QIc a bond Me a bond NH 0 a bond Q3g OH
4980 CMe NEt QIc a bond Me a bond NH 0 a bond Q3h OH
4981 CMe S QIa a bond Me a bond NH 0 a bond Q3g OH
4982 CMe S QIa a bond Me a bond NH 0 a bond Q3h OH
4983 CMe S QIb a bond Me a bond NH 0 a bond Q3g OH
4984 CMe S QIb a bond Me a bond NH 0 a bond Q3h OH
4985 CMe S QIc a bond Me a bond NH 0 a bond Q3g OH
4986 CMe S QIc a bond Me a bond NH 0 a bond Q3h OH
4987 CMe O QIa a bond Me a bond NH 0 a bond Q3g OH
4988 CMe 0 QIa a bond Me a bond NH 0 a bond Q3h OH
4989 CMe O QIb a bond Me a bond NH 0 a bond Q3g OH
4990 CMe 0 QIb a bond Me a bond NH 0 a bond Q3h OH
4991 CMe 0 QIc a bond Me a bond NH 0 a bond Q3g OH
4992 CMe 0 QIc a bond Me a bond NH 0 a bond Q3h OH
4992 CMe 0 QIc a bond Me a bond NH 0 a bond Q3h OH
4993 CH NH QIa a bond Me a bond NH S NH Q3a OH
4994 CH NH QIa a bond Me a bond NH S NH Q3b OH
4995 CH NH QIa a bond Me a bond NH S NH Q3c OH
4996 CH NH QIa a bond Me a bond NH S a bond Q3a OH
4997 CH NH QIa a bond Me a bond NH S a bond Q3b OH
4998 CH NH QIa a bond Me a bond NH S a bond Q3c OH
4999 CH NH QIa a bond Me a bond "NH 0 NH Q3a OH
5000 CH NH QIa a bond Me a bond NH 0 NH Q3b OH
5001 CH NH QIa a bond Me a bond NH 0 NH Q3c OH
5002 CH NH QIa a bond Me a bond NH 0 a bond Q3a OH
5003 CH NH QIa a bond Me a bond NH 0 a bond Q3b OH
5004 CH NH QIa a bond Me a bond NH 0 a bond Q3c OH
5005 CH NH QIa a bond H a bond NH S I M Q3a OH
5006 CH NH QIa a bond H a bond NH S I M Q3b OH
5007 CH NH QIa a bond H a bond NH S NH Q3c OH
5008 CH NH QIa a bond H a bond NH S a bond Q3a OH
5009 CH NH QIa a bond H a bond NH S a bond Q3b OH 5010 CH NH QIa a bond H a bond NH S a bond Q3c OH
5011 CH NH QIa a bond H a bond NH 0 NH Q3a OH
5012 CH NH QIa a bond H a bond NH 0 NH Q3b OH
5013 CH NH QIa a bond H a bond NH 0 NH Q3c OH
5014 ' CH NH QIa a bond H a bond NH 0 a bond Q3a OH
5015 CH NH QIa a bond H a bond NH 0 a bond Q3b OH
5016 CH NH QIa a bond H a bond NH 0 a bond Q3c OH
5017 CH NH QIb a bond Me a bond NH S NH Q3a OH
5018 CH NH QIb a bond Me a bond NH S NH Q3b OH
5019 CH NH QIb a bond Me a bond NH S NH Q3c OH
5020 CH NH QIb a bond Me a bond NH S a bond Q3a OH
5021 CH NH QIb a bond Me a bond NH S a bond Q3b OH
5022 CH NH QIb a bond Me a bond NH S a bond Q3c OH
5023 CH NH QIb a bond Me a bond NH 0 NH Q3a OH
5024 CH NH QIb a bond Me a bond NH 0 NH Q3b OH
5025 CH NH QIb a bond Me a bond NH 0 NH Q3c OH
5026 CH NH QIb a bond Me a bond NH 0 a bond Q3a OH
5027 CH NH QIb a bond Me a bond NH 0 a bond Q3b OH
5028 CH NH QIb a bond Me a bond NH 0 a bond Q3c OH
5029 CH NH QIb a bond H a bond NH S NH Q3a OH
5030 CH NH QIb a bond H a bond NH S NH Q3b OH
5031 CH NH QIb a bond H a bond NH S NH Q3c OH
5032 CH NH QIb a bond H a bond NH S a bond Q3a OH
5033 CH NH QIb a bond H a bond NH S a bond Q3b OH
5034 CH NH QIb a bond H a bond NH S a bond Q3c OH
5035 CH NH QIb a bond H a bond NH 0 NH Q3a OH
5036 CH NH QIb a bond H a bond NH 0 NH Q3b OH
5037 CH NH QIb a bond H a bond NH 0 NH Q3c OH
5038 CH NH QIb a bond H a bond NH 0 a bond Q3a OH
5039 CH NH QIb a bond H a bond NH 0 a bond Q3b OH
5040 CH NH QIb a bond H a bond NH 0 a bond Q3c OH
5041 CH NH QIc a bond Me a bond NH S NH Q3a OH
5042 CH NH QIc a bond Me a bond NH S NH Q3b OH
5043. CH NH QIc a bond Me a bond NH S NH Q3c OH
5044 CH NH QIc a bond Me a bond NH S a bond Q3a OH
5045 CH NH QIc a bond Me a bond NH S a bond Q3b OH 5046 CH NH QIc a bond Me a bond NH S a bond Q3c OH
5047 CH NH QIc a bond Me a bond NH 0 NH Q3a OH
5048 CH NH QIc a bond Me a bond I 0 I 03b OH
5049 CH NH QIc a bond Me a bond NH 0 NH Q3c OH 5050 CH NH QIc a bond Me a bond NH O a bond Q3a OH
5051 CH NH QIc a bond Me a bond NH O a bond Q3b OH
5052 CH NH QIc a bond Me a bond NH O a bond Q3c OH
5053 CH NH QIc a bond H a bond NH S NH Q3a OH
5054 CH NH QIc a bond H a bond NH S NH Q3b OH 5055 CH NH QIc a bond H a bond NH S NH Q3c OH
5056 CH NH QIc a bond H a bond NH S a bond Q3a OH
5057 CH NH QIc a bond H a bond NH S a bond Q3b OH
5058 CH NH QIc a bond H a bond NH S a bond Q3c OH
5059 CH NH QIc a bond H a bond NH 0 NH Q3a OH 5060 CH NH QIc a bond H a bond NH 0 NH Q3b OH
5061 CH NH QIc a bond H a bond NH 0 NH Q3c OH
5062 CH NH QIc a bond H a bond NH O a bond Q3a OH
5063 CH NH QIc a bond H a bond NH O a bond Q3b OH
5064 CH NH QIc a bond H a bond NH O a bond Q3c OH 5065 CH NH QId a bond Me a bond NH S NH Q3a OH
5066 CH NH QId a bond Me a bond NH S NH Q3b OH
5067 CH NH QId a bond Me a bond NH S NH Q3c OH
5068 CH NH QId a bond Me a bond NH S a bond Q3a OH
5069 CH NH QId a bond Me a bond NH S a bond Q3b OH 5070 CH NH QId a bond Me a bond NH S a bond Q3c OH
5071 CH NH QId a bond Me a bond NH 0 NH . Q3a OH
5072 CH NH QId a bond Me a bond NH 0 NH Q3b OH
5073 CH NH QId a bond Me a bond NH 0 NH Q3c OH
5074 CH NH QId a bond Me a bond NH O a bond Q3a OH 5075 CH NH QId a bond Me a bond NH O a bond Q3b OH
5076 CH NH QId a bond Me a bond NH O a bond Q3c OH
5077 CH NH QId a bond H a bond NH S NH Q3a OH
5078 CH NH QId a bond H a bond NH S NH Q3b OH
5079 CH NH QId a bond H a bond NH S NH Q3c OH 5080 CH NH QId a bond H a bond NH S a bond Q3a OH
5081 CH NH QId a bond H a bond NH S a bond Q3b OH 5082 CH NH QId a bond H a bond NH S a bond Q3c OH
5083 CH NH QId a bond H a bond NH 0 NH Q3a OH
5084 CH NH QId a bond H a bond NH 0 NH Q3b OH
5085 CH NH QId a bond H a bond NH 0 NH Q3c OH
5086 CH NH QId a bond H a bond NH 0 a bond Q3a OH
5087 CH NH QId a bond H a bond NH 0 a bond Q3b OH
5088 CH NH QId a bond H a bond NH 0 a bond Q3c OH
5089 CH NH QIe a bond Me a bond NH S NH Q3a OH
5090 CH NH QIe a bond Me a bond NH S NH Q3b OH
5091 CH NH QIe a bond Me a bond NH S NH Q3c OH
5092 CH NH QIe a bond Me a bond NH S a bond Q3a OH
5093 CH NH QIe a bond Me a bond NH S a bond Q3b OH
5094 CH NH QIe a bond Me a bond NH S a bond Q3c OH
5095 CH NH QIe a bond Me a bond NH 0 NH Q3a OH
5096 CH NH QIe a bond Me a bond NH 0 NH Q3b OH
5097 CH NH QIe a bond Me a bond NH 0 NH Q3c OH
5098 CH NH QIe a bond Me a bond NH 0 a bond Q3a OH
5099 CH NH QIe a bond Me a bond NH 0 a bond Q3b OH
5100 CH NH QIe a bond Me a bond NH 0 a bond Q3c OH
5101 CH NH QIe a bond H a bond NH S NH Q3a OH
5102 CH NH QIe a bond H a bond NH S NH Q3b OH
5103 CH NH QIe a bond H a bond NH S NH Q3c OH
5104 CH NH QIe a bond H a bond NH S a bond Q3a OH
5105 CH NH QIe a bond H a bond NH S a bond Q3b OH
5106 CH NH QIe a bond H a bond NH S a bond Q3c OH
5107 CH NH QIe a bond H a bond NH 0 NH Q3a OH
5108 CH NH QIe a bond H a bond NH 0 NH Q3b OH
5109 CH NH QIe a bond H a bond NH 0 NH Q3c OH
5110 CH NH QIe a bond H a bond NH 0 a bond Q3a OH
5111 CH NH QIe a bond H a bond NH 0 a bond Q3b OH
5112 CH NH QIe a bond H a bond NH 0 a bond Q3c OH
5113 CH NH QIf a bond Me a bond NH S NH Q3a OH
5114 CH NH QIf a bond Me a bond NH S NH Q3b OH
5115 CH NH QIf a bond Me a bond NH S NH Q3c OH
5116 CH NH QIf a bond Me a bond NH S a bond Q3a OH
5117 CH NH QIf a bond Me a bond NH S a bone 1 Q3b OH 5118 CH NH QIf a bond Me a bond NH S a bond Q3c OH
5119 CH NH QIf a bond Me a bond NH 0 NH Q3a OH
5120 CH NH QIf a bond Me a bond NH 0 NH Q3b OH
5121 CH NH QIf a bond Me a bond NH 0 NH Q3c OH
5122 CH NH QIf a bond Me a bond 'NH 0 a bond Q3a . OH
5123 CH NH QIf a bond Me a bond NH 0 a bond Q3b OH
5124 CH NH QIf a bond Me a bond NH 0 a bond Q3c OH
5125 CH NH QIf a bond H a bond NH S NH Q3a OH
5126 CH NH QIf a bond H a bond NH S NH Q3b OH
5127 CH NH QIf a bond H a bond NH S NH Q3c OH
5128 CH NH QIf a bond H a bond NH S a bond Q3a OH
5129 CH NH QIf a bond H a bond NH S a bond Q3b OH
5130 CH NH QIf a bond H a bond NH S a bond Q3c OH
5131 CH NH QIf a bond H a bond NH 0 NH Q3a OH
5132 CH NH QIf a bond H a bond NH 0 NH Q3b OH
5133 CH NH QIf a bond H a bond NH 0 NH Q3c OH
5134 CH NH QIf a bond H a bond NH 0 a bond Q3a OH
5135 CH NH QIf a bond H a bond NH 0 a bond Q3b OH
5136 CH NH QIf a bond H a bond NH 0 a bond Q3c OH
5137 CH NH QIg a bond Me a bond NH S NH Q3a OH
5138 CH NH QIg a bond Me a bond NH S NH Q3b OH
5139 CH NH QIg a bond Me a bond NH S NH Q3c OH
5140 CH NH QIg a bond Me a bond NH S a bond Q3a OH
5141 CH NH QIg a bond Me a bond NH S a bond Q3b OH
5142 CH NH QIg a bond Me a bond NH S a bond Q3c OH
5143 CH NH QIg a bond Me a bond NH 0 NH Q3a OH
5144 CH NH QIg a bond Me a bond NH 0 NH Q3b OH
5145 CH NH QIg a bond Me a bond NH 0 NH Q3c OH
5146 CH NH Qig a bond Me a bond NH 0 a bond Q3a OH
5147 CH NH Qig a bond Me a bond NH 0 a bond Q3b OH
5148 CH NH Qig a bond Me a bond NH 0 a bond Q3c OH
5149 CH NH Qig a bond H a bond NH S NH Q3a OH
5150 CH NH Qig a bond H a bond NH S NH Q3b OH
5151 CH NH Qig a bond H a bond NH S NH Q3c OH
5152 CH NH Qig a bond H a bond NH S a bond Q3a OH
5153 CH NH Qig a bond H a bond NH S a bond Q3b OH 5154 CH NH QIg a bond H a bond NH S a bond Q3c OH
5155 CH NH QIg a bond H a bond NH 0 I Q3a OH
5156 CH NH QIg a bond H a bond NH 0 I Q3b OH
5157 CH NH QIg a bond H a bond NH 0 1 Q3c OH
5158 CH NH QIg a bond H a bond NH 0 a bond Q3a OH
5159 CH NH QIg a bond H a bond NH 0 a bond Q3b OH
5160 CH NH Qig a bond H a bond NH 0 a bond Q3c OH
5161 CH NH QIh a bond Me a bond NH S NH Q3a OH
5162 CH NH QIh a bond Me a bond NH S NH Q3b OH
5163 CH NH QIh a bond Me a bond NH S NH Q3c OH
5164 CH NH QIh a bond Me a bond NH S a bond Q3a . OH
5165 CH NH QIh a bond Me a bond NH S a bond Q3b OH
5166 CH NH QIh a bond Me a bond NH S a bond Q3c OH
5167 CH NH QIh a bond Me a bond NH 0 NH Q3a OH
5168 CH NH QIh a bond Me a bond NH 0 NH Q3b OH
5169 CH NH QIh a bond Me a bond NH 0 NH Q3c OH
5170 CH NH QIh a bond Me a bond NH 0 a bond Q3a . OH
5171 CH NH QIh a bond Me a bond NH 0 a bond Q3b OH
5172 CH NH QIh a 'bond Me a bond NH 0 a bond Q3c OH
5173 CH NH QIh a bond H a bond NH S 1 Q3a OH
5174 CH NH QIh a bond H a bond NH S I Q3b OH
5175 CH NH QIh a bond H a bond NH S I Q3c OH
5176 CH NH QIh a bond H a bond NH S a bond Q3a OH
5177 CH NH QIh a bond H a bond NH S a bond Q3b OH
5178 CH NH QIh a bond H a bond NH S a bond Q3c OH
5179 CH NH QIh a bond H a bond NH 0 ϊ Q3a OH
5180 CH NH QIh a bond H a bond NH 0 I Q3b OH
5181 CH NH QIh a bond H a bond NH 0 1 Q3c OH
5182 CH NH QIh a bond H a bond NH 0 a bond Q3a OH
5183 CH NH QIh a bond H a bond NH 0 a bond Q3b OH
5184 CH NH QIh a bond H a bond NH 0 a bond Q3c OH
5185 CH NH QIi a bond Me a bond NH S NH Q3a OH
5186 CH NH QIi a bond Me a bond NH S NH Q3b OH
5187 CH NH QIi a bond Me a bond NH S NH Q3c OH
5188 CH NH QIi a bond Me a bond NH S a bond Q3a OH
5189 CH NH QIi a bond Me a bond NH S a bond Q3b OH 5190 CH NH QIi a bond Me a bond NH S a bond Q3c OH
5191 CH NH QIi a bond Me a bond NH 0 NH Q3a OH
5192 CH NH QIi a bond Me a bond NH 0 NH Q3b OH
5193 CH NH QIi a bond Me a bond NH 0 NH Q3c OH
5194 CH NH QIi a bond Me a bond 'NH 0 a bond Q3a . OH
5195 CH NH QIi a bond Me a bond NH 0 a bond Q3b OH
5196 CH NH QIi a bond Me a bond NH 0 a bond Q3c OH
5197 CH NH QIi a bond H a bond NH S NH Q3a OH
5198 CH NH QIi a bond H a bond NH S NH Q3b OH
5199 CH NH QIi a bond H a bond NH S NH Q3c OH
5200 CH NH QIi a bond H a bond NH S a bond Q3a OH
5201 CH NH QIi a bond H a bond NH S a bond Q3b OH
5202 CH NH QIi a bond H a bond NH S a bond Q3c OH
5203 CH NH QIi a bond H a bond NH 0 NH Q3a OH
5204 CH NH QIi a bond H a bond NH 0 NH Q3b OH
5205 CH NH QIi a bond H a bond NH 0 NH Q3c OH
5206 CH NH QIi a bond H a bond NH 0 a bond Q3a OH
5207 CH NH QIi a bond H a bond NH 0 a bond Q3b OH
5208 CH NH QIi a bond H a bond NH 0 a bond Q3c OH
5209 CH NH QIj a bond Me a bond NH S NH Q3a OH
5210 CH NH QIj a bond Me a bond NH S NH Q3b OH
5211 CH NH QIj a bond Me a bond NH S NH Q3c OH
5212 CH NH Qij a bond Me a bond NH S a bond Q3a OH
5213 CH NH QIj a bond Me a bond NH S a bond Q3b OH
5214 CH NH Qij a bond Me a bond NH S a bond Q3c OH
5215 CH 'NH QIj a bond Me a bond NH 0 NH Q3a OH
5216 CH NH Qij a bond Me a bond NH 0 NH Q3b OH
5217 CH NH Qij a bond Me a bond NH 0 NH Q3c OH
5218 CH NH Qij a bond Me a bond NH 0 a bond Q3a OH
5219 CH NH Qij a bond Me a bond NH 0 a bond Q3b OH
5220 CH NH Qij a bond Me a bond NH 0 a bond Q3c OH
5221 CH NH Qij a bond H a bond NH S NH Q3a OH
5222 CH NH Qij a bond H a bond NH S NH Q3b OH
5223 CH NH Qlj a bond H a bond NH S NH Q3c OH
5224 CH NH Qij a bond H a bond NH S a bond Q3a OH
5225 CH NH Qlj a bond H a bond NH S a bond Q3b OH 5226 CH NH QIj a bond H a bond I S a bond Q3c OH
5227 CH NH Qij a bond H a bond I 0 NH Q3a OH
5228 CH NH QIj a bond H a bond I NJH 0 NH Q3b OH
5229 CH NH Qij a bond H a bond I 0 NH Q3c OH
5230 CH NH Qij a bond H a bond I 0 a bond Q3a OH
5231 CH NH Qij a bond H a bond I 0 a bond Q3b OH
5232 CH NH Qij a bond H a bond I ^JH 0 a bond Q3c OH
5233 CMe NH QIa a bond Me a bond NH S NH Q3a OH
5234 CMe NH QIa a bond Me a bond NH S NH Q3b OH
5235 CMe NH QIa a bond Me a bond NH S NH Q3c OH
5236 CMe NH QIa a bond Me a bond NH S a bond Q3a OH
5237 CMe NH QIa a bond Me a bond NH S a bond Q3b OH
5238 CMe NH QIa a bond Me a bond NH S a bond Q3c OH
5239 CMe NH QIa a bond Me a bond NH 0 NH Q3a OH
5240 CMe NH QIa a bond Me a bond NH 0 NH Q3b OH
5241 CMe NH QIa a bond Me a bond NH 0 NH Q3c OH
5242 CMe NH QIa a bond Me a bond NH 0 a bond Q3a OH
5243 CMe NH QIa a bond Me a bond NH 0 a bond Q3b OH
5244 CMe NH QIa a bond Me a bond NH 0 a bond Q3c OH
5245 CMe NH QIa a bond H a bond NH S NH Q3a OH
5246 CMe NH QIa a bond H a bond NH S NH Q3b OH
5247 CMe NH QIa a bond H a bond NH S NH Q3c OH
5248 CMe NH QIa a bond H a bond NH S a bond Q3a OH
5249 CMe NH QIa a bond H a bond NH S a bond Q3b OH
5250 CMe NH QIa a bond H a bond NH S a bond Q3c OH
5251 CMe NH QIa a bond H a bond NH 0 NH Q3a OH
5252 CMe NH QIa a bond H a bond NH 0 NH Q3b OH
5253 CMe NH QIa a bond H a bond NH 0 NH Q3c OH
5254 CMe NH QIa a bond H a bond NH 0 a bond Q3a OH
5255 CMe NH QIa a bond H a bond NH 0 a bond Q3b OH
5256 CMe NH QIa a bond H a bond NH 0 a bond Q3c OH
5257 CMe NH QIb a bond Me a bond NH S NH Q3a OH
5258 CMe NH QIb a bond Me a bond NH S NH Q3b OH
5259 CMe NH QIb a bond Me a bond NH S NH Q3c OH
5260 CMe NH QIb a bond Me a bond NH S a bond Q3a OH
5261 CMe NH QIb a bond Me a bond NH S a bond Q3b OH 5262 CMe NH QIb a bond Me a bond NH S a bond Q3c OH
5263 CMe NH QIb a bond Me a bond NH 0 NH Q3a OH
5264 CMe NH QIb a bond Me a bond NH 0 NH Q3b OH
5265 CMe NH QIb a bond Me a bond NH 0 NH Q3c OH 5266 CMe NH QIb a bond Me a bond' NH O a bond Q3a OH
5267 CMe NH QIb a bond Me a bond NH O a bond Q3b OH
5268 CMe NH QIb a bond Me a bond NH O a bond Q3c OH
5269 CMe NH QIb a bond H a bond NH S NH Q3a OH
5270 CMe NH QIb a bond H a bond NH S NH Q3b OH 5271 CMe NH QIb a bond H a bond NH S NH Q3c OH
5272 CMe NH QIb a bond H a bond NH S a bond Q3a OH
5273 CMe NH QIb a bond H a bond NH S a bond Q3b OH
5274 CMe NH QIb a bond H a bond NH S a bond Q3c OH
5275 CMe NH QIb a bond H a bond NH 0 NH Q3a OH 5276 CMe NH QIb a bond H a bond NH 0 NH Q3b OH
5277 CMe NH QIb a bond H a bond NH 0 NH Q3c OH
5278 CMe NH QIb a bond H a bond NH O a bond Q3a OH
5279 CMe NH QIb a bond H a bond NH O a bond Q3b OH
5280 CMe NH QIb a •bond H a bond NH O a bond Q3c OH 5281 CMe NH QIc a bond Me a bond NH S NH Q3a OH
5282 CMe NH QIc a bond Me a bond NH S NH Q3b OH
5283 CMe NH QIc a bond Me a bond NH S NH Q3c OH
5284 CMe NH QIc a bond Me a bond NH S a bond Q3a OH
5285 CMe NH QIc a bond Me a bond NH S a bond Q3b OH 5286 CMe NH QIc a bond Me a bond NH S a bond Q3c OH
5287 CMe NH QIc a bond Me a bond NH 0 NH Q3a OH
5288 CMe NH QIc a bond Me a bond NH 0 NH Q3b OH
5289 CMe NH QIc a bond Me a bond NH 0 NH Q3c OH
5290 CMe NH QIc a bond Me a bond NH O a bond Q3a OH 5291 CMe NH QIc a bond Me a bond NH O a bond Q3b OH
5292 CMe NH QIc a bond Me a bond NH O a bond Q3c OH
5293 CMe NH QIc a bond H a bond NH S NH Q3a OH
5294 CMe NH QIc a bond H a bond NH S NH Q3b OH
5295 CMe NH QIc a bond H a bond NH S NH Q3c OH 5296 CMe NH QIc a bond H a bond NH S a bond Q3a OH
5297 CMe NH QIc a bond H a bond NH S a bond Q3b OH 5298 CMe NH QIc a bond H a bond NH S a bond Q3c OH
5299 CMe NH QIc a bond H a bond NH 0 NH Q3a OH
5300 CMe NH QIc a bond H a bond NH 0 NH Q3b OH
5301 CMe NH QIc a bond H a bond NH 0 NH Q3c OH
5302 CMe NH QIc a bond H a bond NH 0 a bond Q3a OH
5303 CMe NH QIc a bond H a bond NH 0 a bond Q3b OH
5304 CMe NH QIc a bond H a bond NH 0 a bond Q3c OH
5305 CMe NH QId a bond Me a bond NH S NH Q3a OH
5306 CMe NH QId a bond Me a bond NH S NH Q3b OH
5307 CMe NH QId a bond Me a bond NH S NH Q3c OH
5308 CMe NH QId a bond Me a bond NH S a bond Q3a OH
5309 CMe NH QId a bond Me a bond NH S a bond Q3b OH
5310 CMe NH QId a bond Me a bond NH S a bond Q3c OH
5311 CMe NH QId a bond Me a bond NH 0 NH Q3a OH
5312 CMe NH QId a bond Me a bond NH 0 NH Q3b OH
5313 CMe NH QId a bond Me a bond NH 0 NH Q3c OH
5314 CMe NH QId a bond Me a bond NH 0 a bond Q3a OH
5315 CMe NH QId a bond Me a bond NH 0 a bond Q3b OH
5316 CMe NH QId a bond Me a bond NH 0 a bond Q3c OH
5317 CMe NH QId a bond H a bond NH S NH Q3a OH
5318 CMe NH QId a bond H a bond NH S NH Q3b OH
5319 CMe NH QId a bond H a bond NH S NH Q3c OH
5320 CMe NH QId a bond H a bond NH S a bond Q3a OH
5321 CMe NH QId a bond H a bond NH S a bond Q3b OH
5322 CMe NH QId a bond H a bond NH S a bond Q3c OH
5323 CMe NH QId a bond H a bond NH 0 NH Q3a OH
5324 CMe NH QId a bond H a bond NH 0 NH Q3b OH
5325 CMe NH QId a bond H a bond NH 0 NH Q3c OH
5326 CMe NH QId a bond H a bond NH 0 a bond Q3a OH
5327 CMe NH QId a bond H a bond NH 0 a bond Q3b OH
5328 CMe NH QId a bond H a bond NH 0 a bond Q3c OH
5329 CMe NH QIe a bond Me a bond NH S NH Q3a OH
5330 CMe NH QIe a bond Me a bond NH S NH Q3b OH
5331 CMe NH QIe a bond Me a bond NH S NH Q3c OH
5332 CMe NH QIe a bond Me a bond NH S a bond Q3a OH
5333 CMe NH QIe a bond Me a bond NH S a bond Q3b OH 39:
5334 CMe NH QIe a bond Me a bond NH S a bond Q3c OH
5335 CMe NH QIe a bond Me a bond NH 0 NH Q3a OH
5336 CMe NH QIe a bond Me a bond NH 0 NH Q3b OH
5337 CMe NH QIe a bond Me a bond NH 0 NH Q3c OH
5338 CMe NH QIe a bond Me a bond NH 0 a bond Q3a . OH
5339 CMe NH QIe a bond Me a bond NH 0 a bond Q3b OH
5340 CMe NH QIe a bond Me a bond NH 0 a bond Q3c OH
5341 CMe NH QIe a bond H a bond NH S NH Q3a OH
5342 CMe NH QIe a bond H a bond NH S NH Q3b OH
5343 CMe NH QIe a bond H a bond NH S NH Q3c OH
5344 CMe NH QIe a bond H a bond NH S a bond Q3a OH
5345 CMe NH QIe a bond H a bond NH S a bond Q3b OH
5346 CMe NH QIe a bond H a bond NH S a bond Q3c OH
5347 CMe NH QIe a bond H a bond NH 0 NH Q3a OH
5348 CMe NH QIe a bond H a bond NH 0 NH Q3b OH
5349 CMe NH QIe a bond H a bond NH 0 NH Q3c OH
5350 CMe NH QIe a bond H a bond NH 0 a bond Q3a OH
5351 CMe NH QIe a bond H a bond NH 0 a bond Q3b OH
5352 CMe NH QIe a bond H a bond NH 0 a bond Q3c OH
5353 CMe NH QIf a bond Me a bond NH S NH Q3a OH
5354 CMe NH QIf a bond Me a bond NH S NH Q3b OH
5355 CMe NH QIf a bond Me a bond NH S NH Q3c OH
5356 CMe NH QIf a bond Me a bond NH S a bond Q3a OH
5357 CMe NH QIf a bond Me a bond NH S a bond Q3b OH
5358 CMe NH QIf a bond Me a bond NH S a bond Q3c OH
5359 CMe NH QIf a bond Me a bond NH 0 NH Q3a OH
5360 CMe NH QIf a bond Me a bond NH 0 NH Q3b OH
5361 CMe NH QIf a bond Me a bond NH 0 NH Q3c OH
5362 CMe NH QIf a bond Me a bond NH 0 a bond Q3a OH
5363 CMe NH QIf a bond Me a bond NH 0 a bond Q3b OH
5364 CMe NH QIf a bond Me a bond NH 0 a bond Q3c OH
5365 CMe NH QIf a bond H a bond NH S NH Q3a OH
5366 CMe NH QIf a' bond H a bond NH S NH Q3b OH
5367 CMe NH QIf a bond H a bond NH S NH Q3c OH
5368 CMe NH QIf a bond H a bond NH S a bond Q3a OH
5369 CMe NH QIf a bond H a bond NH S a bond Q3b OH 5370 CMe NH QIf a bond H a bond NH S a bond Q3c OH
5371 CMe NH QIf a bond H a bond NH 0 NH Q3a OH
5372 CMe NH QIf a bond H a bond I 0 I 03b OH
5373 CMe NH QIf a bond H a bond NH 0 NH Q3c OH 5374 CMe NH QIf a bond H a bond 'NH O a bond Q3a OH
5375 CMe NH QIf a bond H a bond NH O a bond Q3b OH
5376 CMe NH QIf a bond H a bond NH O a bond Q3c OH
5377 CMe NH QIg a bond Me a bond NH S NH Q3a OH
5378 CMe NH QIg a bond Me a bond NH S NH Q3b OH 5379 CMe NH QIg a bond Me a bond NH S NH Q3c OH
5380 CMe NH QIg a bond Me a bond NH S a bond Q3a OH
5381 CMe NH QIg a bond Me a bond NH S a bond Q3b OH
5382 CMe NH QIg a bond Me a bond NH S a bond Q3c OH
5383 CMe NH QIg a bond Me a bond NH 0 NH Q3a OH 5384 CMe NH QIg a bond Me a bond NH 0 NH Q3b OH
5385 CMe NH QIg a bond Me a bond NH 0 NH Q3c OH
5386 CMe NH QIg a bond Me a bond NH O a bond Q3a OH
5387 CMe NH QIg a bond Me a bond NH O a bond Q3b OH
5388 CMe NH QIg a bond Me a bond NH O a bond Q3c OH 5389 CMe NH QIg a bond H a bond NH S NH Q3a OH
5390 CMe NH QIg a bond H a bond NH S NH Q3b OH
5391 CMe NH QIg a bond H a bond NH S NH Q3c OH
5392 CMe NH QIg a bond H a bond NH S a bond Q3a OH
5393 CMe NH QIg a bond H a bond NH S a bond Q3b OH 5394 CMe NH QIg a bond H a bond NH S a bond Q3c OH
5395 CMe NH QIg a bond H a bond NH 0 NH Q3a OH
5396 CMe NH QIg a bond H a bond NH 0 NH Q3b OH
5397 CMe NH QIg a bond H a bond NH 0 NH Q3c OH
5398 CMe NH QIg a bond H a bond NH O a bond- Q3a OH 5399 CMe NH QIg a bond H a bond NH O a bond Q3b OH
5400 CMe NH QIg a bond H a bond NH O a bond Q3c OH
5401 CMe NH QIh a bond Me a bond NH S NH Q3a OH
5402 CMe NH QIh a bond Me a bond NH S NH Q3b OH 5403. CMe NH QIh a bond Me a bond NH S NH Q3c OH 5404 CMe NH QIh a bond Me a bond NH S a bond Q3a OH
5405 CMe NH QIh a bond Me a bond NH S a bond Q3b OH 5406 CMe NH QIh a bond Me a bond NH S a bond Q3c OH
5407 CMe NH QIh a bond Me a bond NH 0 NH Q3a OH
5408 CMe NH QIh a bond Me a bond NH 0 NH Q3b OH
5409 CMe NH QIh a bond Me a bond NH 0 NH Q3c OH 5410 CMe NH QIh a bond Me a bond' NH O a bond Q3a OH
5411 CMe NH QIh a bond Me a bond NH O a bond Q3b OH
5412 CMe NH QIh a bond Me a bond NH O a bond Q3c OH
5413 CMe NH QIh a bond H a bond NH S NH Q3a OH
5414 CMe NH QIh a bond H a bond NH S NH Q3b OH 5415 CMe NH QIh a bond H a bond NH S NH Q3c OH
5416 CMe NH QIh a bond H a bond NH S a bond Q3a OH
5417 CMe NH QIh a bond H a bond NH S a bond Q3b OH
5418 CMe NH QIh a bond H a bond NH S a bond Q3c OH
5419 CMe NH QIh a bond H a bond NH 0 NH Q3a OH 5420 CMe NH QIh a bond H a bond NH 0 NH Q3b OH
5421 CMe NH QIh a bond H a bond NH 0 NH Q3c OH
5422 CMe NH QIh a bond H a bond NH O a bond Q3a OH
5423 CMe NH QIh a bond H a bond NH O a bond Q3b OH
5424 CMe NH QIh a bond H a bond NH O a bond Q3c OH 5425 CMe NH QIi a bond Me a bond NH S NH Q3a OH
5426 CMe NH QIi a bond Me a bond NH S NH Q3b OH
5427 CMe NH QIi a bond Me a bond NH S NH Q3c OH
5428 CMe NH QIi a bond Me a bond NH S a bond Q3a OH
5429 CMe NH QIi a bond Me a bond NH S a bond Q3b OH 5430 CMe NH QIi a bond Me a bond NH S a bond Q3c OH
5431 CMe NH QIi a bond Me a bond NH 0 NH Q3a OH
5432 CMe NH QIi a bond Me a bond NH 0 NH Q3b OH
5433 CMe NH QIi a bond Me. a bond NH 0 NH Q3c OH
5434 CMe NH QIi a bond Me a bond NH O a bond Q3a OH 5435 CMe NH QIi a bond Me a bond NH O a bond Q3b OH
5436 CMe NH QIi a bond Me a bond NH O a bond Q3c OH
5437 CMe NH QIi a bond H a bond NH S NH Q3a OH
5438 CMe NH QIi a bond H a bond NH S NH Q3b OH
5439 CMe NH QIi a bond H a bond NH S NH Q3c OH 5440 CMe NH QIi a bond H a bond NH S a bond Q3a OH
5441 CMe NH QIi a bond H a bond NH S a bond Q3b OH 39E
5442 CMe NH QIi a bond H a bond NH S a bond Q3c OH
5443 CMe NH QIi a bond H a bond NH 0 NH Q3a OH
5444 CMe NH QIi a bond H a bond NH 0 NH Q3b OH
5445 CMe NH QIi a bond H a bond NH 0 NH Q3c OH
5446 CMe NH QIi a bond H a bond NH 0 a bond Q3a OH
5447 CMe NH QIi a bond H a bond NH 0 a bond Q3b OH
5448 CMe NH QIi a bond H a bond NH 0 a bond Q3c OH
5449 CMe NH QIj a bond Me a bond NH S NH Q3a OH
5450 CMe NH QlJ a bond Me a bond NH S NH Q3b OH
5451 CMe NH QIj a bond Me a bond NH S NH Q3c OH
5452 CMe NH QIj a bond Me a bond NH S a bone 1 Q3a . OH
5453 CMe NH QIj a bond Me a bond NH S a bone 1 Q3b OH
5454 CMe NH Qij a bond Me a bond NH S a bone 1 Q3c OH
5455 CMe NH QIj a bond Me a bond NH 0 NH Q3a OH
5456 CMe NH Qij a bond Me a bond NH 0 NH Q3b OH
5457 CMe NH Qij a bond Me a bond NH 0 NH Q3c OH
5458 CMe NH Qij a bond Me a bond NH 0 a bone 1 Q3a OH
5459 CMe NH Qij a bond Me a bond NH 0 a bone 1 Q3b OH
5460 CMe NH Qij a bond Me a bond NH 0 a bone 1 Q3c OH
5461 CMe NH Qij a bond H a bond NH S NH Q3a OH
5462 CMe NH Qij a bond H a bond NH S NH Q3b OH
5463 CMe NH Qij a bond H a bond NH S NH Q3c OH
5464 CMe NH Qij a bond H a bond NH S a bond Q3a OH
5465 CMe NH Qij a bond H a bond NH S a bond Q3b OH
5466 CMe NH Qij a bond H a bond NH S a bond Q3c OH
5467 CMe NH Qij a bond H a bond NH 0 NH Q3a OH
5468 CMe NH Qij a bond H a bond NH 0 NH Q3b OH
5469 CMe NH Qij a bond H a bond NH 0 NH Q3c OH
5470 CMe NH Qij a bond H a bond NH 0 a bond Q3a OH
5471 CMe NH Qij a bond H a bond NH 0 a bond Q3b OH
5472 CMe NH QIj a bond H a bond NH 0 a bond Q3c OH
5473 N NMe QIa a bond Me a bond NH S a bond Q3g OH
5474 N N Me QIa a bond Me a bond NH S a bond Q3h OH
5475 N NMe QIa a bond H a bond NH S a bond Q3g OH 5476 N NMe QIa a bond H a bond NH S a bond Q3h OH 5477 N NMe QIa a bond Me a bond NH 0 a bond Q3g OH 5478 N NMe QIa a bond Me a bond NH 0 a bond Q3h OH
5479 N NMe QIa a bond H a bond NH 0 a bond Q3g OH
5480 N NMe QIa a bond H a bond NH 0 a bond Q3h OH
5481 N NMe QIb a bond Me a bond NH S a bond Q3g OH 5482 N NMe QIb a bond Me a bond NH S a bond Q3h OH
5483 N NMe QIb a bond H a bond NH S a bond Q3g OH
5484 N NMe QIb a bond H a bond NH S a bond Q3h OH
5485 N NMe QIb a bond Me a bond NH 0 a bond Q3g OH
5486 N NMe QIb a bond Me a bond NH 0 a bond Q3h OH 5487 N NMe QIb a bond H a bond NH 0 a bond Q3g OH
5488 N NMe QIb a bond H a bond NH 0 a bond Q3h OH
5489 N NMe QIc a bond Me a bond NH S a bond Q3g OH
5490 N NMe QIc a bond Me a bond NH S a bond Q3h OH
5491 N NMe QIc a bond H a bond NH S a bond Q3g OH 5492 N NMe QIc a bond H a bond NH S a bond Q3h OH
5493 N NMe QIc a bond Me a bond NH 0 a bond Q3g OH
5494 N NMe QIc a bond Me a bond NH 0 a bond Q3h OH
5495 N NMe QIc a bond H a bond NH 0 a bond Q3g OH
5496 N NMe QIc a bond H a bond NH 0 a bond Q3h OH 5497 CH S QIa a bond Me a bond NH S a bond Q3g OH
5498 CH S QIa a bond Me a bond NH S a bond Q3h OH
5499 CH S QIa a bond H a bond NH S a bond Q3g OH
5500 CH S QIa a bond H a bond NH S a bond Q3h OH
5501 CH S QIa a bond Me a bond NH 0 a bond Q3g OH 5502 CH S QIa a bond Me a bond NH 0 a bond Q3h OH
5503 CH S QIa a bond H a bond NH 0 a bond Q3g OH
5504 N NMe QIg a bond Me a bond NH 0 a bond Q3d OH
5505 N NMe QIg a bond Me a bond NH 0 a bond Q3e OH
5506 N NMe QIg a bond Me a bond NH 0 a bond Q3f OH 5507 N NMe QIg a bond Me a bond NH 0 a bond Q3g OH
5508 N NMe QIg a bond Me a bond NH 0 a bond Q3h OH
5509 N NMe QIg a bond H a bond NH 0 a bond Q3d OH
5510 N NMe QIg a bond H a bond NH 0 a bond Q3e OH
5511 N NMe QIg a bond H a bond NH 0 a bond Q3f OH 5512 N NMe QIg a bond H a bond NH 0 a bond Q3g OH
5513 N NMe QIg a bond H a bond NH 0 a bond Q3h OH 5514 N NMe QIh a bond Me a bond NH S a bond Q3d OH
5515 N NMe QIh a bond Me a bond NH S a bond Q3e OH
5516 N NMe QIh a bond Me a bond NH S a bond Q3f OH
5517 N NMe QIh a bond Me a bond NH S a bond Q3g OH 5518 N NMe QIh a bond Me a bond NH S a bond Q3h OH
5519 N NMe QIh a bond H a bond NH S a bond Q3d OH
5520 N NMe QIh a bond H a bond NH S a bond Q3e OH
5521 N NMe QIh a bond H a bond NH S a bond Q3f OH
5522 N NMe QIh a bond H a bond NH S a bond Q3g OH 5523 N NMe QIh a bond H a bond NH S a bond Q3h OH
5524 N NMe QIh a bond Me a bond NH 0 a bond Q3d OH
5525 N NMe QIh a bond Me a bond NH 0 a bond Q3e OH
5526 N NMe QIh a bond Me a bond NH 0 a bond Q3f OH
5527 N NMe QIh a bond Me a bond NH 0 a bond Q3g OH 5528 N NMe QIh a bond Me a bond NH 0 a bond Q3h OH
5529 N NMe QIh a bond H a bond NH 0 a bond Q3d OH
5530 N NMe QIh a bond H a bond NH 0 a bond Q3e OH
5531 N NMe QIh a bond H a bond NH 0 a bond Q3f OH
5532 N NMe QIh a bond H a bond NH 0 a bond Q3g OH 5533 N NMe QIh a. bond H a bond NH 0 a bond Q3h OH
5534 N NMe QIi a bond Me a bond NH S a bond Q3d OH
5535 N NMe QIi a bond Me a bond NH S a bond Q3e OH
5536 N NMe QIi a bond Me a bond NH S a bond Q3f OH
5537 N NMe QIi a bond Me a bond NH S a bond Q3g OH 5538 N NMe QH a bond Me a bond NH S a bond Q3h OH
5539 N NMe QIi a bond H a bond NH S a bond Q3d OH
5540 N NMe QIi a bond H a bond NH S a bond Q3e OH
5541 N NMe QIi a bond H a bond NH S a bond Q3f OH
5542 N NMe QIi a bond H a bond NH S a bond Q3g OH 5543 N NMe QIi a bond H a bond NH S a bond Q3h OH
5544 N NMe QIi a bond Me a bond NH 0 a bond Q3d OH
5545 N NMe QIi a bond Me a bond NH 0 a bond Q3e OH
5546 N NMe QIi a bond Me a bond NH 0 a bond Q3f OH
5547 N NMe QIi a bond Me a bond NH 0 a bond Q3g OH 5548 N NMe QIi a bond Me a bond NH 0 a bond Q3h OH
5549 N NMe QIi a bond H a bond NH 0 a bond Q3d OH 5550 N NMe QIi a bond H a bond NH 0 a bond Q3e OH
5551 N NMe QIi a bond H a bond NH 0 a bond Q3f OH
5552 N NMe QIi a bond H a bond NH 0 a bond Q3g OH
5553 N NMe QIi a bond H a bond NH 0 a bond Q3h OH 5554 N NMe QIj a bond Me a bond 'NH S a bond Q3d OH
5555 N NMe QIj a bond Me a bond NH S a bond Q3e OH
5556 N NMe QIj a bond Me a bond NH S a bond Q3f OH
5557 N NMe QIj a bond Me a bond NH S a bond Q3g OH
5558 N NMe QIj a bond Me a bond NH S a bond Q3h OH
5559 N NMe QIj a bond H a bond NH S a bond Q3d OH
5560 N NMe Qij a bond H a bond NH S a bond Q3e OH
5561 N NMe QIj a bond H a bond NH S a bond Q3f OH
5562 N NMe Qij a bond H a bond NH S a bond Q3g OH
5563 N NMe Qij a bond H a bond NH S a bond Q3h OH
5564 N NMe Qij a bond Me a bond NH 0 a bond Q3d OH
5565 N NMe Qij a bond Me a bond NH 0 a bond Q3e OH
5566 N NMe Qij a bond Me a bond NH 0 a bond Q3f OH
5567 N NMe Qij a bond Me a bond NH 0 a bond Q3g OH
5568 N NMe Qij a bond Me a bond NH 0 a bond Q3h OH
5569 N NMe Qij a bond H a bond NH 0 a bond Q3d OH
5570 N NMe Qij a bond H a bond NH 0 a bond Q3e OH
5571 N NMe Qij a bond H a bond NH 0 a bond Q3f OH
5572 N NMe Qij a bond H a bond NH 0 a bond Q3g OH
5573 N NMe Qij a bond H a bond NH 0 a bond Q3h OH
5574 CH S QIf a bond Me a bond NH S a bond Q3d OH
5575 CH S QIf a bond Me a bond NH S a bond Q3e OH
5576 CH S QIf a bond Me a bond NH S a bond Q3f OH
5577 CH S QIf a bond Me a bond NH S a bond Q3g OH
5578 CH S QIf a bond Me a bond NH S a bond Q3h OH
5579 CH S QIf a bond H a bond NH S a bond Q3d OH
5580 CH S QIf a bond H a bond NH S a bond Q3e OH
5581 CH S QIf a bond H a bond NH S a bond Q3f OH
5582 CH S QIf a bond H a bond NH S a bond Q3g OH
5583. CH S QIf a bond H a bond NH S a bond Q3h OH
5584 CH S QIf a bond Me a bond NH 0 a bond Q3d OH
5585 CH S QIf a bond Me a bond NH 0 a bond Q3e OH 5586 CH S QIf a bond Me a bond NH 0 a bond Q3f OH
5587 CH S QIf a bond Me a bond NH 0 a bond Q3g OH
5588 CH S QIf a bond Me a bond NH 0 a bond Q3h OH
5589 CH S QIf a bond H a bond NH 0 a bond Q3d OH
5590 CH S QIf a bond H a bond NH 0 a bond Q3e OH
5591 CH S QIf a bond H a bond NH 0 a bond Q3f OH
5592 CH S QIf a bond H a bond NH 0 a bond Q3g OH
5593 CH S QIf a bond H a bond NH 0 a bond Q3h OH
5594 CH S QIg a bond Me a bond NH S a bond Q3d OH
5595 CH S QIg a bond Me a bond NH S a bond Q3e OH
5596 CH S QIg a bond Me a bond NH S a bond Q3f OH
5597 CH S QIg a bond Me a bond NH S a bond Q3g OH
5598 CH S QIg a bond Me a bond NH S a bond Q3h OH
5599 CH S QIg a bond H a bond NH S a bond Q3d OH
5600 CH S QIg a bond H a bond NH S a bond Q3e OH
5601 CH S QIg a bond H a bond NH S a bond Q3f OH
5602 CH S QIg a bond H a bond NH S a bond Q3g OH
5603 CH S Qig a bond H a bond NH S a bond Q3h OH
5604 CH S Qig a bond Me a bond NH 0 a bond Q3d OH
5605 CH S Qig a bond Me a bond NH 0 a bond Q3e OH
5606 CH S Qig a bond Me a bond NH 0 a bond Q3f OH
5607 CH S Qig a bond Me a bond NH 0 a bond Q3g OH
5608 CH S Qig a bond Me a bond NH 0 a bond Q3h OH
5609 CH S Qig a bond H a bond NH 0 a bond Q3d OH
5610 CH S QIg a bond H a bond NH 0 a bond Q3e OH
5611 CH S QIg a bond H a bond NH 0 a bond Q3f OH
5612 CH S QIg a bond H a bond NH 0 a bond Q3g OH
5613 CH S QIg a bond H a bond NH 0 a bond Q3h OH
5614 CH S .QIh a bond Me a bond NH S a bond Q3d OH
5615 CH S QIh a bond Me a bond NH S a bond Q3e OH
5616 CH S QIh a bond Me a bond NH S a bond Q3f OH
5617 CH S QIh a bond Me a bond NH S a bond Q3g OH
5618 CH S QIh a bond Me a bond NH S a bond Q3h OH
5619 CH S QIh a bond H a bond NH S a bond Q3d OH
5620 CH S QIh a bond H a bond NH S a bond Q3e OH
5621 CH S QIh a bond H a bond NH S a bond Q3f OH 5622 CH S QIh a bond H a bond NH S a bond Q3g OH
5623 CH S QIh a bond H a bond NH S a bond Q3h OH
5624 CH S QIh a bond Me a bond NH 0 a bond Q3d OH
5625 CH S QIh a bond Me a bond NH 0 a bond Q3e OH
5626 CH S QIh a bond Me a bond 'NH 0 a bond Q3f OH
5627 CH S QIh a bond Me a bond NH 0 a bond Q3g OH
5628 CH S QIh a bond Me a bond NH 0 a bond Q3h OH
5629 CH S QIh a bond H a bond NH 0 a bond Q3d OH
5630 CH S QIh a bond H a bond NH 0 a bond Q3e OH
5631 CH S QIh a bond H a bond NH 0 a bond Q3f OH
5632 CH S QIh a bond H a bond NH 0 a bond Q3g OH
5633 CH S QIh a bond H a bond NH 0 a bond Q3h OH
5634 CH S QIi a bond Me a bond NH S a bond Q3d OH
5635 CH S QIi a bond Me a bond NH S a bond Q3e OH
5636 CH S QIi a bond Me a bond NH S a bond Q3f OH
5637 CH S QIi a bond Me a bond NH S a bond Q3g OH
5638 CH S QIi a bond Me a bond NH S a bond Q3h OH
5639 CH S QIi a bond H a bond NH S a bond Q3d OH
5640 CH S QIi a bond H a bond NH S a bond Q3e OH
5641 CH S QIi a bond H a bond NH S a bond Q3f OH
5642 CH S QIi a bond H a bond NH S a bond Q3g OH
5643 CH S QIi a bond H a bond NH S a bond Q3h OH
5644 CH S QIi a bond Me a bond NH 0 a bond Q3d OH
5645 CH S QIi a bond Me a bond NH 0 a bond Q3e OH
5646 CH S QIi a bond Me a bond NH 0 a bond Q3f OH
5647 CH S QIi a bond Me a bond NH 0 a bond Q3g OH
5648 CH S QIi a bond Me a bond NH 0 a bond Q3h OH
5649 CH S QIi a bond H a bond NH 0 a bond Q3d OH
5650 CH S QIi a bond H a bond NH 0 a bond Q3e OH
5651 CH S QIi a bond H a bond NH 0 a bond Q3f OH
5652 CH S QIi a bond H a bond NH 0 a bond Q3g OH
5653 CH S QIi a bond H a bond NH 0 a bond Q3h OH
5654 CH S QIj a bond Me a bond NH S a bond Q3d OH
5655 CH S QIj a bond Me a bond NH S a bond Q3e OH
5656 CH S QIj a bond Me a bond NH S a bond Q3f OH
5657 CH S QIj a bond Me a bond NH S a bond Q3g OH 5658 CH S QIj a bond Me a bond NH S a bond Q3h OH
5659 CH S QIj a bond H a bond NH S a bond Q3d OH
5660 CH S QIj a bond H a bond NH S a bond Q3e OH
5661 CH S QIj a bond H a bond NH S a bond Q3f OH 5662 CH S QIj a bond H a bond I S a bond Q3g OH
5663 CH S QIj a bond H a bond NH S a bond Q3h OH
5664 CH S QIj a bond Me a bond NH 0 a bond Q3d OH
5665 CH S QIj a bond Me a bond NH 0 a bond Q3e OH
5666 CH S QIj a bond Me a bond NH 0 a bond Q3f OH 5667 CH S QIj a bond Me a bond NH 0 a bond Q3g OH
5668 CH S QIj a bond Me a bond NH 0 a bond Q3h OH
5669 CH S QIj a bond H a bond NH 0 a bond Q3d OH
5670 CH S QIj a bond H a bond NH 0 a bond Q3e OH
5671 CH S QIj a bond H a bond NH 0 a bond Q3f OH 5672 CH S QIj a bond H a bond NH 0 a bond Q3g OH
5673 CH S QIj a bond H a bond NH 0 a bond Q3h OH
5674 N NMe QIk a bond Me a bond NH S a bond Q3b OH
5675 N NMe QIk a bond Me a bond NH S a bond Q3c OH
5676 N NMe QIk a bond Me a bond NH S a bond Q3g OH 5677 N NMe QIk a bond Me a bond NH S a bond Q3h OH
5678 N NMe QIk a bond H a bond NH S a bond Q3b OH
5679 N NMe QIk a bond H a bond NH S a bond Q3c OH
5680 N NMe QIk a bond H a bond NH S a bond Q3g OH
5681 N NMe QIk a bond H a bond NH S a bond Q3h OH 5682 N NMe QIk a bond Me a bond NH 0 a bond Q3b OH
5683 N NMe QIk a bond Me a bond NH 0 a bond Q3c OH
5684 N NMe QIk a bond Me a bond NH 0 a bond Q3g OH
5685 N NMe QIk a bond Me a bond NH 0 a bond Q3h OH
5686 N NMe QIk a bond H a bond NH 0 a bond Q3b OH 5687 N NMe QIk a bond H a bond NH 0 a bond Q3c OH
5688 N NMe QIk a bond H a bond NH 0 a bond Q3g OH
5689 N NMe QIk a bond H a bond NH 0 a bond Q3h OH
5690 N NMe QIl a bond Me a bond NH S a bond Q3b OH
5691 N NMe QIl a bond Me a bond NH S a bond Q3c OH 5692 N NMe QIl a bond Me a bond NH S a bond Q3g OH
5693 N NMe QIl a bond Me a bond NH S a bond Q3h OH 5694 N NMe QIl a bond H a bond NH S a bond Q3b OH
5695 N NMe QIl a bond H a bond NH S a bond Q3c OH
5696 N NMe QIl a bond H a bond NH S a bond Q3g OH
5697 N NMe QIl a bond H a bond NH S a bond Q3h OH 5698 N NMe QIl a bond Me a bond NH 0 a bond Q3b OH
5699 N NMe QIl a bond Me a bond NH 0 a bond Q3c OH
5700 N NMe QIl a bond Me a bond NH 0 a bond Q3g OH
5701 N NMe QIl a bond Me a bond NH 0 a bond Q3h OH
5702 N NMe QIl a bond H a bond NH 0 a bond Q3b OH 5703 N NMe QIl a bond H a bond NH 0 a bond Q3c OH
5704 N NMe QIl a bond H a bond NH 0 a bond Q3g OH
5705 N NMe QIl a bond H a bond NH 0 a bond Q3h OH
5706 N NMe QIm a bond Me a bond NH S a bond Q3b OH
5707 N NMe QIm a bond Me a bond NH S a bond Q3c OH 5708 N NMe QIm a bond Me a bond NH S a bond Q3g OH
5709 N NMe QIm a bond Me a bond NH S a bond Q3h OH
5710 N NMe QIm a bond H a bond NH S a bond Q3b OH
5711 N NMe QIm a bond H a bond NH S a bond Q3c OH
5712 N NMe QIm a bond H a bond NH S a bond Q3g OH 5713 N NMe QIm a bond H a bond NH S a bond Q3h OH
5714 N NMe QIm a bond Me a bond NH 0 a bond Q3b OH
"5715 N NMe QIm a bond Me a bond NH 0 a bond Q3c OH
5716 N NMe QIm a bond Me a bond NH 0 a bond Q3g OH
5717 N NMe QIm a bond Me a bond NH 0 a bond Q3h OH 5718 N NMe QIm a bond H a bond NH 0 a bond Q3b OH
5719 N NMe QIm a bond H a bond NH 0 a bond Q3c OH
5720 N NMe QIm a bond H a bond NH 0 a bond Q3g OH
5721 N NMe QIm a bond H a bond NH 0 a bond Q3h OH
5722 N NMe QIn a bond Me a bond NH S a bond Q3b OH 5723 N NMe QIn a bond Me a bond NH S a bond Q3c OH
5724 N NMe QIn a bond Me a bond NH S a bond Q3g OH
5725 N NMe QIn a bond Me a bond NH S a bond Q3h OH
5726 N NMe QIn a bond H a bond NH S a bond Q3b OH
5727 N NMe QIn a bond H a bond NH S a bond Q3c OH 5728 N NMe QIn a bond H a bond NH S a bond Q3g OH
5729 N NMe QIn a bond H a bond NH S a bond Q3h OH 5730 N NMe QIn a bond Me a bond NH 0 a bond Q3b OH
5731 N NMe QIn a bond Me a bond NH 0 a bond Q3c OH
5732 N NMe QIn a bond Me a bond NH 0 a bond Q3g OH
5733 N NMe QIn a bond Me a bond NH 0 a bond Q3h OH 5734 N NMe QIn a bond H a bond NH 0 a bond Q3b OH
5735 N NMe QIn a bond H a bond NH 0 a bond Q3c OH
5736 N NMe QIn a bond H a bond NH 0 a bond Q3g OH
5737 N NMe QIn a bond H a bond NH 0 a bond Q3h OH
5738 N NMe QIk' a bond Me a bond NH S a bond Q3b OH 5739 N NMe QIk' a bond Me a bond NH S a bond Q3c OH
5740 N NMe QIk' a bond Me a bond NH S a bond Q3g OH
5741 N NMe QIk' a bond Me a bond NH S a bond Q3h OH
5742 N NMe QIk' a bond H a bond NH S a bond Q3b OH
5743 N NMe QIk' a bond H a bond NH S a bond Q3c OH 5744 N NMe QIk' a bond H a bond NH S a bond Q3g OH
5745 N NMe QIk' a bond H a bond NH S a bond Q3h OH
5746 N NMe QIk' a bond Me a bond NH 0 a bond Q3b OH
5747 N NMe QIk' a bond Me a bond NH 0 a bond Q3c OH
5748 N NMe QIk' a bond Me a bond NH 0 a bond Q3g OH 5749 N NMe QIk' a bond Me a bond NH 0 a bond Q3h OH
5750 N NMe QIk' a bond H a bond NH 0 a bond Q3b OH
5751 N NMe QIk' a bond H a bond NH 0 a bond Q3c OH
5752 N NMe QIk' a bond H a bond NH 0 a bond Q3g OH
5753 N NMe QIk' a bond H a bond NH 0 a bond Q3h OH 5754 N NMe QIl' a bond Me a bond NH S a bond Q3b OH
5755 N NMe QIl' a bond Me a bond NH S a bond Q3c OH
5756 N NMe Ql1' a bond Me a bond NH S a bond Q3g OH
5757 N NMe QIl' a bond Me a bond NH S a bond Q3h OH
5758 N NMe QIl' a bond H a bond NH S a bond Q3b OH 5759 N NMe QIl' a bond H a bond NH S a bond Q3c OH
5760 N NMe QIl' a bond H a bond NH S a bond Q3g OH
5761 N NMe QIl' a bond H a bond NH S a bond Q3h OH
5762 N NMe QIl' a bond Me a bond NH 0 a bond Q3b OH
5763 N NMe QIl' a bond Me a bond NH 0 a bond Q3c OH 5764 N NMe QIl' a bond Me a bond NH 0 a bond Q3g OH
5765 N NMe QIl' a bond Me a bond NH 0 a bond Q3h OH 5766 N NMe QIl' a bond H a bond NH 0 a bond Q3b OH
5767 N NMe QlI' a bond H a bond NH 0 a bond Q3c OH
5768 N NMe QIl' a bond H a bond NH 0 a bond Q3g OH
5769 N NMe Ql1' a bond H a bond NH 0 a bond Q3h OH 5770 N NMe QIm' a bond Me a bond NH S a bond Q3b OH
5771 N NMe QIm' a bond Me a bond NH S a bond Q3c OH
5772 N NMe QIm' a bond Me a bond NH S a bond Q3g OH
5773 N NMe QIm' a bond Me a bond NH S a bond Q3h OH
5774 N NMe QIm' a bond H a bond NH S a bond Q3b OH 5775 N NMe QIm' a bond H a bond NH S a bond Q3c OH
5776 N NMe QIm' a bond H a bond NH S a bond Q3g OH
5777 N NMe QIm' a bond H a bond NH S a bond Q3h OH
5778 N NMe QIm' a bond Me a bond NH 0 a bond Q3b OH
5779 N NMe QIm' a bond Me a bond NH 0 a bond Q3c OH 5780 N NMe QIm' a bond Me a bond NH 0 a bond Q3g OH
5781 N NMe QIm' a bond Me a bond NH 0 a bond Q3h OH
5782 N NMe QIm' a bond H a bond NH 0 a bond Q3b OH
5783 N NMe QIm' a bond H a bond NH 0 a bond Q3c OH
5784 N NMe QIm' a bond H a bond NH 0 a bond Q3g OH 5785 N NMe QIm' a bond H a bond NH 0 a bond Q3h OH
5786 N NMe QIn' a bond Me a bond NH S a bond Q3b OH
5787 N NMe QIn' a bond Me a bond NH S a bond Q3c OH
5788 N NMe QIn' a bond Me a bond NH S a bond Q3g OH
5789 N NMe QIn' a bond Me a bond NH S a bond Q3h OH 5790 N NMe QIn' a bond H a bond NH S a bond Q3b OH
5791 N NMe QIn' a bond H a bond NH S a bond Q3c OH
5792 N NMe QIn' a bond H a bond NH S a bond Q3g OH
5793 N NMe QIn' a bond H. a bond NH S a bond Q3h OH
5794 N NMe QIn' a bond Me a bond NH 0 a bond Q3b OH 5795 N NMe QIn' a bond Me a bond NH 0 a bond Q3c OH
5796 N NMe QIn' a bond Me a bond NH 0 a bond Q3g OH
5797 N NMe QIn' a bond Me a bond NH 0 a bond Q3h OH
5798 N NMe QIn' a bond H a bond NH 0 a bond Q3b OH
5799 N NMe QIn' a bond H a bond NH 0 a bond Q3c OH 5800 N NMe QIn' a bond H a bond NH 0 a bond Q3g OH
5801 N NMe QIn' a bond H a bond NH 0 a bond Q3h OH 5802 CH S QIk a bond Me a bond NH S a bond Q3b OH
5803 CH S QIk a bond Me a bond NH S a bond Q3c OH
5804 CH S QIk a bond Me a bond NH S a bond Q3g OH
5805 CH S QIk a bond Me a bond NH S a bond Q3h OH
5806 CH S QIk a bond H a bond NH S a bond Q3b OH
5807 CH S QIk a bond H a bond NH S a bond Q3c OH
5808 CH S QIk a bond H a bond NH S a bond Q3g OH
5809 CH S QIk a bond H a bond NH S a bond Q3h OH
5810 CH S QIk a bond Me a bond NH 0 a bond Q3b OH
5811 CH S QIk a bond Me a bond NH 0 a bond Q3c OH
5812 CH S QIk a bond Me a bond NH 0 a bond Q3g OH
5813 CH S QIk a bond Me a bond NH 0 a bond Q3h OH
5814 CH S QIk a bond H a bond NH 0 a bond Q3b OH
5815 CH S QIk a bond H a bond NH 0 a bond Q3c OH
5816 CH S QIk a bond H a bond NH 0 a bond Q3g OH
5817 CH S QIk a bond H a bond NH 0 a bond Q3h OH
5818 CH S QIl a bond Me a bond NH S a bond Q3b OH
5819 CH S QIl a bond Me a bond NH S a bond Q3c OH
5820 CH S QIl a bond Me a bond NH S a bond Q3g OH
5821 CH S QU a bond Me a bond NH S a bond Q3h OH
5822 CH S QIl a bond H a bond NH S a bond Q3b OH
5823 CH S QIl a bond H a bond NH S a bond Q3c OH
5824 CH S QIl a bond H a bond NH S a bond Q3g OH
5825 CH S QIl a bond H a bond NH S a bond Q3h OH
5826 CH S QIl a bond Me a bond NH 0 a bond Q3b OH
5827 CH S QIl a bond Me a bond NH 0 a bond Q3c OH
5828 CH S QIl a bond Me a bond NH 0 a bond Q3g OH
5829 CH S QIl a bond Me a bond NH 0 a bond Q3h OH
5830 CH S QIl a bond H a bond NH 0 a bond Q3b OH
5831 CH S QIl a bond H a bond NH 0 a bond Q3c OH
5832 CH S QIl a bond H a bond NH 0 a bond Q3g OH
5833 CH S QIl a bond H a bond NH 0 a bond Q3h OH
5834 CH S QIm a bond Me a bond NH S a bond Q3b OH
5835 CH S QIm a bond Me a bond NH S a bond Q3c OH
5836 CH S QIm a bond Me a bond NH S a bond Q3g OH
5837 CH S QIm a bond Me a bond NH S a bond Q3h OH 5838 CH S QIm a bond H a bond NH S a bond Q3b OH
5839 CH S QIm a bond H a bond NH S a bond Q3c OH
5840 CH S QIm a bond H a bond NH S a bond Q3g OH
5841 CH S QIm a bond H a bond NH S a bond Q3h OH 5842 CH S QIm a bond Me a bond NH 0 a bond Q3b OH
5843 CH S QIm a bond Me a bond NH 0 a bond Q3c OH
5844 CH S QIm a bond Me a bond NH 0 a bond Q3g OH
5845 CH S QIm a bond Me a bond NH 0 a bond Q3h OH
5846 CH S QIm a bond H a bond NH 0 a bond Q3b OH 5847 CH S QIm a bond H a bond NH 0 a bond Q3c OH
5848 CH S QIm a bond H a bond NH 0 a bond Q3g OH
5849 CH S QIm a bond H a bond NH 0 a bond Q3h OH
5850 CH S QIn a bond Me a bond NH S a bond Q3b OH
5851 CH S QIn a bond Me a bond NH S a bond Q3c OH 5852 CH S QIn a bond Me a bond NH S a bond Q3g OH
5853 CH S QIn a bond Me a bond NH S a bond Q3h OH
5854 CH S QIn a bond H a bond NH S a bond Q3b OH
5855 CH S QIn a bond H a bond NH S a bond Q3c OH
5856 CH S QIn a bond H a bond NH S a bond Q3g OH 5857 CH S QIn a bond H a bond NH S a bond Q3h OH
5858 CH S QIn a bond Me a bond NH 0 a bond Q3b OH
5859 CH S QIn a bond Me a bond NH 0 a bond Q3c OH
5860 CH S QIn a bond Me a bond NH 0 a bond Q3g OH
5861 CH S QIn a bond Me a bond NH 0 a bond Q3h OH 5862 CH S QIn a bond H a bond NH 0 a bond Q3b OH
5863 CH S QIn a bond H a bond NH 0 a bond Q3c OH
5864 CH S QIn a bond H a bond NH 0 a bond Q3g OH
5865 CH S QIn a bond H a bond NH 0 a bond Q3h OH
5866 CH S QIk' a bond Me a bond NH S a bond Q3b OH 5867 CH S QIk' a bond Me a bond NH S a bond Q3c OH
5868 CH S QIk' a bond Me a bond NH S a bond Q3g OH
5869 CH S QIk' a bond Me a bond NH S a bond Q3h OH
5870 CH S QIk' a bond H a bond NH S a bond Q3b OH
5871 CH S QIk' a bond H a bond NH S a bond Q3c OH 5872 CH S QIk' a bond H a bond NH S a bond Q3g OH
5873 CH S QIk' a bond H a bond NH S a bond Q3h OH 55887744 CCHH SS QQIIkk'' a bond Me a bond NH 0 a bond Q3b OH
5 5887755 C CHH S S Q QIIkk'' a bond Me a bond NH 0 a bond Q3c OH
5 5887766 C CHH S S Q QIIkk'' a bond Me a bond NH 0 a bond Q3g OH
5 5887777 C CHH S S Q QIIkk'' a bond Me a bond NH 0 a bond Q3h OH
5 5887788 C CHH S S Q QIIkk'' a bond H a bond NH 0 a bond Q3b OH
5 5887799 C CHH S S Q QIIkk'' a bond H a bond NH 0 a bond Q3c OH
5 5888800 C CHH S S Q QIIkk'' a bond H a bond NH 0 a bond Q3g OH
5 5888811 C CHH S S Q QIIkk'' a bond H a bond NH 0 a bond Q3h OH
5 5888822 C CHH S S Q QIllI'' a bond Me a bond NH S a bond Q3b OH
5 5888833 C CHH S S Q QliIΓ' a bond Me a bond NH S a bond Q3c OH
5 5888844 C CHH S S Q QiiΓΓ a bond Me a bond NH S a bond Q3g OH
5 5888855 C CHH S S Q QiiΓΓ a bond Me a bond NH S a bond Q3h OH
5 5888866 C CHH S S Q QiiΓΓ a bond H a bond NH S a bond Q3b OH
5 5888877 C CHH S S Q QllII'' a bond H a bond NH S a bond Q3c OH
5888 CH S Qir a bond H a bond NH S a bond Q3g OH
5889 CH S QiΓ a bond H a bond NH S a bond Q3h OH
5890 CH S QlI' a bond Me a bond NH 0 a bond Q3b OH
5 5889911 C CHH S S Q Qiirr a bond Me a bond NH 0 a bond Q3c OH
5 5889922 C CHH S S Q QiiΓΓ a bond Me a bond NH 0 a bond Q3g OH
5 5889933 C CHH S S Q QiiΓΓ a bond Me a bond NH 0 a bond Q3h OH
5 5889944 C CHH S S Q QIIll'' a bond H a bond NH 0 a bond Q3b OH
5 5889955 C CHH S S Q Qiirr a bond H a bond NH 0 a bond Q3c OH
5 5889966 C CHH S S Q QIIll'' a bond H a bond NH 0 a bond Q3g OH
5 5889977 C CHH S S Q Qiirr a bond H a bond NH 0 a bond Q3h OH
5 5889988 C CHH S S Q QIImm'' a bond Me a bond NH S a bond Q3b OH
5 5889999 C CHH S S Q QIImm'' a bond Me a bond NH S a bond Q3c OH
5 5990000 C CHH S S Q QIImm'' a bond Me a bond NH S a bond Q3g OH
5 5990011 C CHH S S Q QIImm'' a bond Me a bond NH S a bond Q3h OH
5 5990022 C CHH S S Q QIImm'' a bond H a bond NH S a bond Q3b OH
5 5990033 C CHH S S Q QIImm'' a bond H a bond NH S a bond Q3c OH
5 5990044 C CHH S S Q QIImm'' a bond H a bond NH S a bond Q3g OH
5 5990055 C CHH S S Q QIImm'' a bond H a bond NH S a bond Q3h OH
5 5990066 C CHH S S Q QIImm'' a bond Me a bond NH 0 a bond Q3b OH
5 5990077 C CHH S S Q QIImm'' a bond Me a bond NH 0 a bond Q3c OH
5 5990088 C CHH S S Q QIImm'' a bond Me a bond NH 0 a bond Q3g OH
5 5990099 C CHH S S Q QIImm'' a bond Me a bond NH 0 a bond Q3h OH 5910 CH S QIm' a bond H a bond NH 0 a bond Q3b OH
5911 CH S QIm' a bond H a bond NH 0 a bond Q3c OH
5912 CH S QIm' a bond H a bond NH 0 a bond Q3g OH
5913 CH S QIm' a bond H a bond NH 0 a bond Q3h OH 5914 CH S QIn' a bond Me a bond NH S a bond Q3b OH
5915 CH S QIn' a bond Me a bond NH S a bond Q3c OH
5916 CH S QIn' a bond Me a bond NH S a bond Q3g OH
5917 CH S QIn' a bond Me a bond NH S a bond Q3h OH
5918 CH S QIn' a bond H a bond NH S a bond Q3b OH 5919 CH S QIn' a bond H a bond NH S a bond Q3c OH
5920 CH S QIn' a bond H a bond NH S a bond Q3g OH
5921 CH S QIn' a bond H a bond NH S a bond Q3h OH
5922 CH S QIn' a bond Me a bond NH 0 a bond Q3b OH
5923 CH S QIn' a bond Me a bond NH 0 a bond Q3c OH 5924 CH S QIn' a bond Me a bond NH 0 a bond Q3g OH
5925 CH S QIn' a bond Me a bond NH 0 a bond Q3h OH
5926 CH S QIn' a bond H a bond NH 0 a bond Q3b OH
5927 CH S QIn' a bond H a bond NH 0 a bond Q3c OH
5928 CH S QIn' a bond H a bond NH 0 a bond Q3g OH 5929 CH S QIn' a bond H a bond NH 0 a bond Q3h OH
5930 CH S QId a bond Me a bond NH S a bond Q3d OH
5931 CH S QId a bond Me a bond NH S a bond Q3e OH
5932 CH S QId a bond Me a bond NH S a bond Q3f OH
5933 CH S QId a bond Me a bond NH S a bond Q3g OH 5934 CH S QId a bond Me a bond NH S a bond Q3h OH
5935 CH S QId a bond H a bond NH S a bond Q3d OH
5936 CH S QId a bond H a bond NH S a bond Q3e OH
5937 CH S QId a bond H a. bond NH S a bond Q3f OH
5938 CH S QId a bond H a bond NH S a bond Q3g OH 5939 CH S QId a bond H a bond NH S a bond Q3h OH
5940 CH S QId a bond Me a bond NH 0 a bond Q3d OH
5941 CH S QId a bond Me a bond NH 0 a bond Q3e OH
5942 CH S QId a bond Me a bond NH 0 a bond Q3f OH
5943 CH S QId a bond Me a bond NH 0 a bond Q3g OH 5944 CH S QId a bond Me a bond NH 0 a bond Q3h OH
5945 CH S QId a bond H a bond NH 0 a bond Q3d OH 5946 CH S QId a bond H a bond NH 0 a bond Q3e OH
5947 CH S QId a bond H a bond NH 0 a bond Q3f OH
5948 CH S QId a bond H a bond NH 0 a bond Q3g OH
5949 CH S QId a bond H a bond NH 0 a bond Q3h OH 5950 CH S QIe a bond Me a bond NH S a bond Q3d OH
5951 CH S QIe a bond Me a bond NH S a bond Q3e OH
5952 CH S QIe a bond Me a bond NH S a bond Q3f OH
5953 CH S QIe a bond Me a bond NH S a bond Q3g OH
5954 CH S QIe a bond Me a bond NH S a bond Q3h OH 5955 CH S QIe a bond H a bond NH S a bond Q3d OH
5956 CH S QIe a bond H a bond NH S a bond Q3e OH
5957 CH S QIe a bond H a bond NH S a bond Q3f OH
5958 CH S QIe a bond H a bond NH S a bond Q3g OH
5959 CH S QIe a bond H a bond NH S a bond Q3h OH 5960 CH S QIe a bond Me a bond NH 0 a bond Q3d OH
5961 CH S QIe a bond Me a bond NH 0 a bond Q3e OH
5962 CH S QIe a bond Me a bond NH 0 a bond Q3f OH
5963 CH S QIe a bond Me a bond NH 0 a bond Q3g OH
5964 CH S QIe a bond Me a bond NH 0 a bond Q3h OH 5965 CH S QIe a bond H a bond NH 0 a bond Q3d OH
5966 CH S QIe a bond H a bond NH 0 a bond Q3e OH
5967 CH S QIe a bond H a bond NH 0 a bond Q3f OH
5968 CH S QIe a bond H a bond NH 0 a bond Q3g OH
5969 CH S QIe a bond H a bond NH 0 a bond Q3h OH 5 5997700 C CHH S S Q QIIaa a bond H a bond NH 0 a bond Q3h OH
5971 CH S QIb a bond Me a bond NH S a bond Q3g OH
5972 CH S QIb a bond Me a bond NH S a bond Q3h OH
5973 CH S QIb a bond H a bond NH S a bond Q3g OH
5974 CH S QIb a bond H a bond NH S a bond Q3h OH 5 5997755 C CHH S S Q QIIbb a bond Me a bond NH 0 a bond Q3g OH
5976 CH S QIb a bond Me a bond NH 0 a bond Q3h OH
5977 CH S QIb a bond H a bond NH 0 a bond Q3g OH
5978 CH S QIb a bond H a bond NH 0 a bond Q3h OH
5979 CH S QIc a bond Me a bond NH S a bond Q3g OH 5 5998800 C CHH S S Q QIIcc a bond Me a bond NH 'S a bond Q3h OH
5981 CH S QIc a bond H a bond NH S a bond Q3g OH 5982 CH S QIc a bond H a bond NH S a bond Q3h OH
5983 CH S QIc a bond Me a bond NH 0 a bond Q3g OH
5984 CH S QIc a bond Me a bond NH 0 a bond Q3h OH
5985 CH S QIc a bond H a bond NH 0 a bond Q3g OH 5986 CH S QIc a bond H a bond I 0 a bond Q3h OH
5987 N NMe QId a bond Me a bond NH S a bond Q3d OH
5988 N NMe QId a bond Me a bond NH S a bond Q3e OH
5989 N NMe QId a bond Me a bond NH S a bond Q3f OH
5990 N NMe QId a bond Me a bond NH S a bond Q3g OH 5991 N NMe QId a bond Me a bond NH S a bond Q3h OH
5992 N NMe QId a bond H a bond NH S a bond Q3d OH
5993 N NMe QId a bond H a bond NH S a bond Q3e OH
5994 N NMe QId a bond H a bond NH S a bond Q3f OH
5995 N NMe QId a bond H a bond NH S a bond Q3g OH 5996 N NMe QId a bond H a bond NH S a bond Q3h OH
5997 N NMe QId a bond Me a bond NH 0 a bond Q3d OH
5998 N NMe QId a bond Me a bond NH 0 a bond Q3e OH
5999 N NMe QId a bond Me a bond NH 0 a bond Q3f OH
6000 N NMe QId a bond Me a bond NH 0 a bond Q3g OH 6001 N NMe QId a bond Me a bond NH 0 a bond Q3h OH
6002 N NMe QId a bond H a bond NH 0 a bond Q3d OH
6003 N NMe QId a bond H a bond NH 0 a bond Q3e OH
6004 N NMe QId a bond H a bond NH 0 a bond Q3f OH
6005 N NMe QId a bond H a bond NH 0 a bond Q3g OH 6006 N NMe QId a bond H a bond NH 0 a bond Q3h OH
6007 N NMe QIe a bond Me a bond NH S a bond Q3d OH
6008 N NMe QIe a bond Me a bond NH S a bond Q3e OH
6009 N NMe QIe a bond Me a bond NH S a bond Q3f OH
6010 N NMe QIe a bond Me a bond NH S a bond Q3g OH 6011 N NMe QIe a bond Me a bond NH S a bond Q3h OH
6012 N NMe QIe a bond H a bond NH S a bond Q3d OH
6013 N NMe QIe a bond H a bond NH S a bond Q3e OH
6014 N NMe QIe a bond H a bond NH S a bond Q3f OH
6015 N NMe QIe a bond H a bond NH S a bond Q3g OH 6016 N NMe QIe a bond H a bond NH S a bond Q3h OH
6017 N NMe QIe a bond Me a bond NH 0 a bond Q3d OH 6018 N Me QIe a bond Me a bond NH 0 a bond Q3e OH
6019 N NMe QIe a bond Me a bond NH 0 a bond Q3f OH
6020 N NMe QIe a bond Me a bond NH 0 a bond Q3g OH
6021 N NMe QIe a bond Me a bond NH 0 a bond Q3h OH 6022 N NMe QIe a bond H a bond NH 0 a bond Q3d OH
6023 N NMe QIe a bond H a bond NH 0 a bond Q3e OH
6024 N NMe QIe a bond H a bond NH 0 a bond Q3f OH
6025 N NMe QIe a bond H a bond NH 0 a bond Q3g OH
6026 N NMe QIe a bond H a bond NH 0 a bond Q3h OH 6027 N NEt QIe a bond Me a bond NH S a bond Q3d OH
6028 CH NMe QIe a bond Me a bond NH S a bond Q3e OH
6029 N O QIe a bond Me a bond NH S a bond Q3f OH
6030 N S QIe a bond Me a bond NH S a bond Q3g OH
6031 CH NEt QIe a bond Me a bond NH S a bond Q3h OH 6032 CMe S QIe a bond H a bond NH S a bond Q3d OH
6033 CH 0 QIe a bond H a bond NH S a bond Q3e OH
6034 CMe 0 QIe a bond H a bond NH S a bond Q3f OH
6035 CMe NMe QIe a bond H a bond NH S a bond Q3g OH
6036 CMe NEt QIe a bond H a bond NH S a bond Q3h OH 6037 CBr S QIb a bond Me a bond NH S a bond Q3a OH
6038 CCl S QIb a bond Me a bond NH S a bond Q3a OH
6039 CF S QIb a bond Me a bond NH S a bond Q3a OH
6040 N NMe QIf a bond Me a bond NH S a bond Q3d OH
6041 N NMe QIf a bond Me a bond NH S a bond Q3e OH 6042 N NMe QIf a bond Me a bond NH S a bond Q3f OH
6043 N NMe QIf a bond Me a bond NH S a bond Q3g OH
6044 N NMe QIf a bond Me a bond NH S a bond Q3h OH
6045 N NMe QIf a bond H a bond NH S a bond Q3d OH
6046 N NMe QIf a bond H a bond NH S a bond Q3e OH 6047 N NMe QIf a bond H a bond NH S a bond Q3f OH
6048 N NMe QIf a bond H a bond NH S a bond Q3g OH
6049 N NMe QIf a bond H a bond NH S a bond Q3h OH
6050 N NMe QIf a bond Me a bond NH 0 a bond Q3d OH
6051 N NMe QIf a bond Me a bond NH 0 a bond Q3e OH 6052 N NMe QIf a bond Me a bond NH 0 a bond Q3f OH
6053 N NMe QIf a bond Me a bond NH 0 a bond Q3g OH 6054 N NMe QIf a bond Me a bond NH 0 a bond Q3h OH
6055 N NMe QIf a bond H a bond NH 0 a bond Q3d OH
6056 N NMe QIf a bond H a bond NH 0 a bond Q3e OH
6057 N NMe QIf a bond H a bond NH 0 a bond Q3f OH
6058 N NMe QIf a bond H a bond NH 0 a bond Q3g OH
6059 N NMe QIf a bond H a bond NH 0 a bond Q3h OH
6060 N NMe QIg a bond Me a bond NH S a bond Q3d OH
6061 N NMe QIg a bond Me a bond NH S a bond Q3e OH
6062 N NMe QIg a bond Me a bond NH S a bond Q3f OH
6063 N NMe QIg a bond Me a bond NH S a bond Q3g OH
6064 N NMe QIg a bond Me a bond NH S a bond Q3h OH
6065 N NMe QIg a bond H a bond NH S a bond Q3d OH
6066 N NMe QIg a bond H a bond NH S a bond Q3e OH
6067 N NMe QIg a bond H a bond NH S a bond Q3f OH
6068 N NMe QIg a bond H a bond NH S a bond Q3g OH
6069 N NMe Qig a bond H a bond NH S a bond Q3h OH
60) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 2 denote the flowing substituents.
Figure imgf000414_0001
TABLE 2
No A B R 1 L 1 R L 3 Y L 4 R 3 X
1 N NMe QIa a bond Me a bond NH S NH T3a OH
2 N NMe QIa a bond Me a bond NH S NH T3b OH
3 N NMe QIa a bond Me a bond NH S NH T3c OH
4 N NMe QIa a bond Me a bond NH S NH T3d OH
5 N NMe QIa a bond Me a bond NH S NH T3e OH
6 N NMe QIa a bond Me a bond NH S NH T3f OH
7 N NMe QIa a bond Me a bond NH S NH T3g OH
8 N NMe QIa a bond Me a bond NH S NH T3h OH
9 N NMe QIa a bond Me a bond NH S NH T3i OH
10 N NMe QIa a bond Me a bond NH S NH T3j OH
11 N NMe QIa a bond Me a bond NH S a bond T3a OH
12 N NMe QIa a bond Me a bond NH S a bond T3b OH
13 N NMe QIa a bond Me a bond NH S a bond T3c OH
14 N NMe QIa a bond Me a bond NH S a bond. T3d OH 15 N NMe QIa a bond Me a bond NH S a bond T3e OH
16 N NMe QIa a bond Me a bond NH S a bond T3f OH
17 N NMe QIa a bond Me a bond NH S a bond T3g OH
18 N NMe QIa a bond Me a bond NH S a bond T3h OH 19 N NMe QIa a bond Me a bond NH S a bond T3i OH
20 N NMe QIa a bond Me a bond NH S a bond T3j OH
21 N NMe QIa a bond Me a bond NH 0 NH T3a OH
22 N NMe QIa a bond Me a bond NH 0 NH T3b OH
23 N NMe QIa a bond Me a bond NH 0 NH T3c OH 24 N NMe QIa a bond Me a bond NH 0 NH T3d OH
25 N NMe QIa a bond Me a bond NH 0 NH T3e OH
26 N NMe QIa a bond Me a bond NH 0 NH T3f OH
27 N NMe QIa a bond Me a bond NH 0 NH T3g OH
28 N NMe QIa a bond Me a bond NH 0 NH T3h OH 29 N NMe QIa a bond Me a bond NH 0 NH T3i OH
30 N NMe QIa a bond Me a bond NH 0 NH T3j OH
31 N NMe QIa a bond Me a bond NH 0 a bond T3a OH
32 N NMe QIa a bond Me a bond NH 0 a bond T3b OH
33 N NMe QIa a bond Me a bond NH 0 a bond T3c OH 34 N NMe QIa a bond Me a bond NH 0 a bond T3d OH
35 N NMe QIa a bond Me a bond NH 0 a bond T3e OH
36 N NMe QIa a bond Me a bond NH 0 a bond T3f OH
37 N NMe QIa a bond Me a bond NH 0 a bond T3g OH
38 N NMe QIa a bond Me a bond NH 0 a bond T3h OH 39 N NMe QIa a bond Me a bond NH 0 a bond T3i OH
40 N NMe QIa a bond Me a bond NH 0 a bond T3j OH
41 N NMe QIa a bond H a bond NH S NH T3a OH
42 N NMe QIa a bond H a bond NH S NH T3b OH
43 N NMe QIa a bond H a bond NH S NH T3c OH 44 N NMe QIa a bond H a bond NH S NH T3d OH
45 N NMe QIa a bond H a bond NH S NH T3e OH
46 N NMe QIa a bond H a bond NH S NH T3f OH
47 N NMe QIa a bond H a bond NH S NH T3g OH
48 N NMe QIa a bond H a bond NH S NH T3h OH 49 N NMe QIa a bond H a bond NH S NH T3i OH
50 N NMe QIa a bond H a bond NH S NH T3j OH 51 N NMe QIa a bond H a bond NH S a bond T3a OH
52 N NMe QIa a bond H a bond NH S a bond T3b OH
53 N NMe QIa a bond H a bond NH S a bond T3c OH
54 N NMe QIa a bond H a bond NH S a bond T3d OH 55 N NMe QIa a bond H a bond NH S a bond T3e OH
56 N NMe QIa a bond H a bond NH S a bond T3f OH
57 N NMe QIa a bond H a bond NH S a bond T3g OH
58 N NMe QIa a bond H a bond NH S a bond T3h OH
59 N NMe QIa a bond H a bond NH S a bond T3i OH 60 N NMe QIa a bond H a bond NH S a bond T3j OH
61 N NMe QIa a bond H a bond NH 0 NH T3a OH
62 N NMe QIa a bond H a bond NH 0 NH T3b OH
63 N NMe QIa a bond H a bond NH 0 NH T3c OH
64 N NMe QIa a bond H a bond NH 0 NH T3d OH 65 N NMe QIa a bond H a bond NH 0 NH T3e OH
66 N NMe QIa a bond H a bond NH 0 NH T3f OH
67 N NMe QIa a bond H a bond NH 0 NH T3g OH
68 N NMe QIa a bond H a bond NH 0 NH T3h OH
69 N NMe QIa a bond H a bond NH 0 NH T3i OH 70 N NMe QIa a bond H a bond NH 0 NH T3j OH
71 N NMe QIa a bond H a bond NH 0 a bond T3a OH
72 N NMe QIa a bond H a bond NH 0 a bond T3b OH
73 N NMe QIa a bond H a bond NH 0 a bond T3c OH
74 N NMe QIa a bond H a bond NH 0 a bond T3d OH 75 N NMe QIa a bond H a bond NH 0 a bond T3e OH
76 N NMe QIa a bond H a bond NH 0 a bond T3f OH
77 N NMe QIa a bond H a bond NH 0 a bond T3g OH
78 N NMe QIa a bond H a bond NH 0 a bond T3h OH
79 N NMe QIa a bond H a bond NH 0 a bond T3i OH 80 N NMe QIa a bond H a bond NH 0 a bond T3j OH
81 N NMe QIb a bond Me a bond NH S NH T3a OH
82 N NMe QIb a bond Me a bond NH S NH T3b OH
83 N NMe QIb a bond Me a bond NH S NH T3c OH
84 N NMe QIb a bond Me a bond NH S NH T3d OH 85 N NMe QIb a bond Me a bond NH S NH T3e OH
86 N NMe QIb a bond Me a bond NH S NH T3f OH 87 N NMe QIb a bond Me a bond NH S NH T3g OH
88 N NMe QIb a bond Me a bond NH S NH T3h OH
89 N NMe QIb a bond Me a bond NH S NH T3i OH
90 N NMe QIb a bond Me a bond NH S NH T3j OH 91 N NMe QIb a bond Me a bond NH S a bond T3a OH
92 N NMe QIb a bond Me a bond NH S a bond T3b OH
93 N NMe QIb a bond Me a bond NH S a bond T3c OH
94 N NMe QIb a bond Me a bond NH S a bond T3d OH
95 N NMe QIb a bond Me a bond NH S a bond T3e OH 96 N NMe QIb a bond Me a bond NH S a bond T3f OH
97 N NMe QIb a bond Me a bond NH S a bond T3g OH
98 N NMe QIb a bond Me a bond NH S a bond T3h OH
99 N NMe QIb a bond Me a bond NH S a bond T3i OH
100 N NMe QIb a bond Me a bond NH S a bond T3j OH 101 N NMe QIb a bond Me a bond NH 0 H T3a OH
102 N NMe QIb a bond Me a bond NH 0 H T3b OH
103 N NMe QIb a bond Me a bond NH 0 NH T3c OH
104 N NMe QIb a bond Me a bond NH 0 NH T3d OH
105 N NMe QIb a bond Me a bond NH 0 NH T3e OH 106 N NMe QIb a bond Me a bond NH 0 NH T3f OH
107 N NMe QIb a bond Me a bond NH 0 NH T3g OH
108 N NMe QIb a bond Me a bond NH 0 NH T3h OH
109 N NMe QIb a bond Me a bond NH 0 NH T3i OH
110 N NMe QIb a bond Me a bond NH 0 NH T3j OH 111 N NMe QIb a bond Me a bond NH 0 a bond T3a OH
112 N NMe QIb a bond Me a bond NH 0 a bond T3b OH
113 N NMe QIb a bond Me a bond NH 0 a bond T3c OH
114 N NMe QIb a bond Me a bond NH 0 a bond T3d OH
115 N NMe QIb a bond Me a bond NH 0 a bond T3e OH 116 N NMe QIb a bond Me a bond NH 0 a bond T3f OH
117 N NMe QIb a bond Me a bond NH 0 a bond T3g OH
118 N NMe QIb a bond Me a bond NH 0 a bond T3h OH
119 N NMe QIb a bond Me a bond NH 0 a bond T3i OH
120 N NMe QIb a bond Me a bond NH 0 a bond T3j OH 121 N NMe QIb a bond H a bond NH S H T3a OH
122 N NMe QIb a bond H a bond NH S H T3b OH 123 N NMe QIb a bond H a bond NH S H T3c OH
124 N NMe QIb a bond H a bond NH S NH T3d OH
125 N NMe QIb a bond H a bond NH S NH T3e OH
126 N NMe QIb a bond H a bond NH S NH T3f OH 127 N NMe QIb a bond H a bond NH S NH T3g OH
128 N NMe QIb a bond H a bond NH S NH T3h OH
129 N NMe QIb a bond H a bond NH S NH T3i OH
130 N NMe QIb a bond H a bond NH S NH T3j OH
131 N NMe QIb a bond H a bond NH S a bond T3a OH 132 N NMe QIb a bond H a bond NH S a bond T3b OH
133 N NMe QIb a bond H a bond NH S a bond T3c OH
134 N NMe QIb a bond H a bond NH S a bond T3d OH
135 N NMe QIb a bond H a bond NH S a bond T3e OH
136 N NMe QIb a bond H a bond NH S a bond T3f OH 137 N NMe QIb a bond H a bond NH S a bond T3g OH
138 N NMe QIb a bond H a bond NH S a bond T3h OH
139 N NMe QIb a bond H a bond NH S a bond T3i OH
140 N NMe QIb a bond H a bond NH S a bond T3j OH
141 N NMe QIb a bond H a bond NH 0 NH T3a OH 142 N NMe QIb a bond H a bond NH 0 NH T3b OH
143 N NMe QIb a bond H a bond NH 0 NH T3c OH
144 N NMe QIb a bond H a bond NH 0 NH T3d OH
145 N NMe QIb a bond H a bond NH 0 NH T3e OH
146 N NMe QIb a bond H a bond NH 0 NH T3f OH 147 N NMe QIb a bond H a bond NH 0 NH T3g OH
148 N NMe QIb a bond H a bond NH 0 NH T3h OH
149 N NMe QIb a bond H a bond NH 0 NH T3i OH
150 N NMe QIb a bond H a bond NH 0 NH T3j OH
151 N NMe QIb a bond H a bond NH 0 a bond T3a OH 152 N NMe QIb a bond H a bond NH 0 a bond T3b OH
153 N NMe QIb a bond H a bond NH 0 a bond T3c OH
154 N NMe QIb a bond H a bond NH 0 a bond T3d OH
155 N NMe QIb a bond H a bond NH 0 a bond T3e OH
156 N NMe QIb a bond H a bond NH 0 a bond T3f OH 157 N NMe QIb a bond H a bond NH 0 a bond T3g OH
158 N NMe QIb a bond H a bond NH 0 a bond T3h OH 159 N NMe QIb a bond H a bond NH O a bond T3i OH
160 N NMe QIb a bond H a bond NH 0 a bond T3j OH
161 N NMe QIc a bond Me a bond NH S NH T3a OH
162 N NMe QIc a bond Me a bond H S NH T3b OH 163 N NMe QIc a bond Me a bond NH S NH T3c OH
164 N NMe QIc a bond Me a bond NH S NH T3d OH
165 N NMe QIc a bond Me a bond NH S NH T3e OH
166 N NMe QIc a bond Me a bond NH S NH T3f OH
167 N NMe QIc a bond Me a bond NH S NH T3g OH 168 N NMe QIc a bond Me a bond NH S NH T3h OH
169 N NMe QIc a bond Me a bond NH S NH T3i OH
170 N NMe QIc a bond Me a bond NH S NH T3j OH
171 N NMe QIc a bond Me a bond NH S a bond T3a OH
172 N NMe QIc a bond Me a bond NH S a bond T3b OH 173 N NMe QIc a bond Me a bond NH S a bond T3c OH
174 N NMe QIc a bond Me a bond NH S a bond T3d OH
175 N NMe QIc a bond Me a bond NH S a bond T3e OH
176 N NMe QIc a bond Me a bond NH S a bond T3f OH
177 N NMe QIc a bond Me a bond NH S a bond T3g OH 178 N NMe QIc a bond Me a bond NH S a bond T3h OH
179 N NMe QIc a bond Me a bond NH S a bond T3i OH
180 N NMe QIc a bond Me a bond NH S a bond T3j OH
181 N NMe QIc a bond Me a bond NH 0 NH T3a OH
182 N NMe QIc a bond Me a bond NH 0 NH T3b OH 183 N NMe QIc a bond Me a' bond NH 0 NH T3c OH
184 N NMe QIc a bond Me a bond NH 0 NH T3d OH
185 N NMe QIc a bond Me a bond NH 0 NH T3e OH
186 N NMe QIc a bond Me a bond NH 0 NH T3f OH
187 N NMe QIc a bond Me a bond NH 0 NH T3g OH 188 N NMe QIc a bond Me a bond NH 0 NH T3h OH
189 N NMe QIc a bond Me a bond NH 0 NH T3i OH
190 N NMe QIc a bond Me a bond NH 0 NH T3j OH
191 N NMe QIc a bond Me a bond NH 0 a bond T3a OH
192 N NMe QIc a bond Me a bond NH 0 a bond T3b OH 193 N NMe QIc a bond Me a bond NH 0 a bond T3c OH
194 N NMe QIc a bond Me a bond NH 0 a bond T3d OH 195 N NMe QIc a bond Me a bond NH 0 a bond T3e OH
196 N NMe QIc a bond Me a bond NH 0 a bond T3f OH
197 N NMe QIc a bond Me a bond NH 0 a bond T3g OH
198 N NMe QIc a bond Me a bond NH 0 a bond T3h OH
5 199 N NMe QIc a bond Me a bond NH 0 a bond T3i OH
200 N NMe QIc a bond Me a bond NH 0 a bond T3j OH
201 N NMe QIc a bond H a bond NH S NH T3a OH
202 N NMe QIc a bond H a bond NH S NH T3b OH
203 N NMe QIc a bond H a bond NH S NH T3c OH o 204 N NMe QIc a bond H a bond NH S NH T3d OH
205 N NMe QIc a bond H a bond NH S NH T3e OH
206 N NMe QIc a bond H a bond NH S NH T3f OH
207 N NMe QIc a bond H a bond NH S NH T3g OH
208 N NMe QIc a bond H a bond NH S H T3h ( )H
5 209 N NMe QIc a bond H a bond NH S NH T3i OH
210 N NMe QIc a bond H a bond NH S NH T3j OH
211 N NMe QIc a bond H a bond NH S a bond T3a OH
212 N NMe QIc a bond H a bond NH S a bond T3b OH
213 N NMe QIc a bond H a bond NH S a bond T3c OH o 214 N NMe QIc a bond H a bond NH S a bond T3d OH
215 N NMe QIc a bond H a bond NH S a bond T3e OH
216 N NMe QIc a bond H a bond NH S a bond T3f OH
217 N NMe QIc a bond H a bond NH S a bond T3g OH
218 N NMe QIc a bond H a bond NH S a bond T3h OH 5 219 N NMe QIc a bond H a bond NH S a bond T3i OH
220 N NMe QIc a bond H a bond NH S a bond T3j OH
221 N NMe QIc a bond H a bond NH 0 NH T3a OH
222 N NMe QIc a bond H a bond NH 0 NH T3b OH
223 N NMe QIc a bond H a bond NH 0 NH T3c OH 0 224 N NMe QIc a bond H a bond NH 0 NH T3d OH
225 N NMe QIc a bond H a bond NH 0 NH T3e OH
226 N NMe QIc a bond H a bond NH 0 NH T3f OH
227 N NMe QIc a bond H a bond NH 0 NH T3g OH
228 N NMe QIc a bond H a bond NH 0 NH T3h OH 5 229 N NMe QIc a bond H a bond NH 0 NH T3i OH
230 N NMe QIc a bond H a bond NH 0 NH T3j OH 231 N NMe QIc a bond H a bond NH 0 a bond T3a OH
232 N NMe QIc a bond H a bond NH 0 a bond T3b OH
233 N NMe QIc a bond H a bond NH 0 a bond T3c OH
234 N NMe QIc a bond H a bond NH 0 a bond T3d OH 235 N NMe QIc a bond H a bond NH 0 a bond T3e OH
236 N NMe QIc a bond H a bond NH 0 a bond T3f OH
237 N NMe QIc a bond H a bond NH 0 a bond T3g OH
238 N NMe QIc a bond H a bond NH 0 a bond T3h OH
239 N NMe QIc a bond H a bond NH 0 a bond T3i OH 240 N NMe QIc a bond H a bond NH 0 a bond T3j OH
241 N NMe QIi a bond Me a bond NH S NH T3a OH
242 N NMe QIi a bond Me a bond NH S NH T3b OH
243 N NMe QIi a bond Me a bond NH S NH T3c OH
244 N NMe QIi a bond Me a bond NH S NH T3d OH 245 N NMe QIi a bond Me a bond NH S NH T3e OH
246 N NMe QIi a bond Me a bond NH S NH T3f OH
247 N NMe QIi a bond Me a bond NH S NH T3g OH
248 N NMe QIi a bond Me a bond NH S NH T3h OH
249 N NMe QIi a bond Me a bond NH S NH T3i OH 250 N NMe QIi a bond Me a bond NH S NH T3j OH
251 N NMe QIi a bond Me a bond NH S a bond T3a OH
252 N NMe QIi a bond Me a bond NH S a bond T3b OH
253 N NMe QIi a bond Me a bond NH S a bond T3c OH
254 N NMe QIi a bond Me a bond NH S a bond T3d OH 255 N NMe QIi a bond Me a bond NH S a bond T3e OH
256 N NMe QIi a bond Me a bond NH S a bond T3f OH
257 N NMe QIi a bond Me a bond NH S a bond T3g OH
258 N NMe QIi a bond Me a bond NH S a bond T3h OH
259 N NMe QIi a bond Me a bond NH S a bond T3i OH 260 N NMe QIi a bond Me a bond NH S a bond T3j OH
261 N NMe QIi a bond Me a bond NH 0 NH T3a OH
262 N NMe QIi a bond Me a bond NH 0 NH T3b OH
263 N NMe QIi a bond Me a bond NH 0 NH T3c OH
264 N NMe QIi a bond Me a bond NH 0 NH T3d OH 265 N NMe QIi a bond Me a bond NH 0 NH T3e OH
266 N NMe QIi a bond Me a bond NH 0 NH T3f OH 267 N NMe QIi a bond Me a bond NH 0 NH T3g OH
268 N NMe QIi a bond Me a bond NH 0 NH T3h OH
269 N NMe QIi a bond Me a bond NH 0 NH T3i OH
270 N NMe QIi a bond Me a bond NH 0 H T3j OH
271 N NMe QIi a bond Me a bond 'NH 0 a bond T3a OH
272 N NMe QIi a bond Me a bond NH 0 a bond T3b OH
273 N NMe QIi a bond Me a bond NH 0 a bond T3c OH
274 N NMe QIi a bond Me a bond NH 0 a bond T3d OH
275 N NMe QIi a bond Me a bond NH 0 a bond T3e OH
276 N NMe QIi a bond Me a bond NH 0 a bond T3f OH
277 N NMe QIi a bond Me a bond NH 0 a bond T3g OH
278 N NMe QIi a bond Me a bond NH 0 a bond T3h OH
279 N NMe QIi a bond Me a bond NH 0 a bond T3i OH
280 N NMe QIi a bond Me a bond NH 0 a bond T3j OH
281 N NMe QIi a bond H a bond NH S NH T3a OH
282 N NMe QIi a bond H a bond NH S NH T3b OH
283 N NMe QIi a bond H a bond NH S NH T3c OH
284 N NMe QIi a bond H a bond NH S NH T3d OH
285 N NMe QIi a bond H a bond NH S NH T3e OH
286 N NMe QIi a bond H a bond NH S NH T3f OH
287 N NMe QIi a bond H a bond NH S NH T3g OH
288 N NMe QIi a bond H a bond NH S NH T3h OH
289 N NMe QIi a bond H a bond NH S NH T3i OH
290 N NMe QIi a bond H a bond NH S NH T3j OH
291 N NMe QIi a bond H a bond NH S a bond T3a OH
292 N NMe QIi a bond H a bond NH S a bond T3b OH
293 N NMe QIi a bond H a bond NH S a bond T3c OH
294 N NMe QIi a bond H a bond NH S a bond T3d OH
295 N NMe QIi a bond H a bond NH S a bond T3e OH
296 N NMe QIi a bond H a bond NH S a bond T3f OH
297 N NMe QIi a bond H a bond NH S a bond T3g OH
298 N NMe QIi a bond H a bond NH S a bond T3h OH
299 N NMe QIi a bond H a bond NH S a bond T3i OH
300 N NMe QIi a bond H a bond NH S a bond T3j OH 301 N NMe QIi a bond H a bond NH 0 H T3a OH 302 N NMe QIi a bond H a bond NH 0 NH T3b OH 303 N NMe QIi a bond H a bond NH 0 NH T3c OH
304 N NMe QIi a bond H a bond NH 0 NH T3d OH
305 N NMe QIi a bond H a bond NH 0 NH T3e OH
306 N NMe QIi a bond H a bond NH 0 NH T3f OH 307 N NMe QIi a bond H a bond NH 0 NH T3g OH
308 N NMe QIi a bond H a bond NH 0 NH T3h OH
309 N NMe QIi a bond H a bond NH 0 NH T3i OH
310 N NMe QIi a bond H a bond NH 0 NH T3j OH
311 N NMe QIi a bond H a bond NH 0 a bond T3a OH 312 N NMe QIi a bond H a bond NH 0 a bond T3b OH
313 N NMe QIi a bond H a bond NH 0 a bond T3c OH
314 N NMe QIi a bond H a bond NH 0 a bond T3d OH
315 N NMe QIi a bond H a bond NH 0 a bond T3e OH
316 N NMe QIi a bond H a bond NH 0 a bond T3f OH 317 N NMe QIi a bond H a bond NH 0 a bond T3g OH
318 N NMe QIi a bond H a bond NH 0 a bond T3h OH
319 N NMe QIi a bond H a bond NH 0 a bond T3i OH
320 N NMe QIi a bond H a bond NH 0 a bond T3j OH
321 N NMe QIj a bond Me a bond NH S NH T3a OH 322 N NMe QIj a bond Me a bond NH S NH T3b OH
323 N NMe QIj a bond Me a bond NH S NH T3c OH
324 N NMe QIj a bond Me a bond NH S NH T3d OH
325 N NMe QIj a bond Me a bond NH S NH T3e OH
326 N^ NMe QIj a bond Me a bond NH S NH T3f OH 327 N NMe QIj a bond Me a bond NH S NH T3g OH
328 N NMe QIj a bond Me a bond NH S NH T3h OH
329 N NMe QIj a bond Me a bond NH S NH T3i OH
330 N NMe QIj a bond Me a bond NH S NH T3j OH
331 N NMe QIj a bond Me a bond NH S a bond T3a OH 332 N NMe QIj a bond Me a bond NH S a bond T3b OH
333 N NMe QIj a bond Me a bond NH S a bond T3c OH
334 N NMe QIj a bond Me a bond NH S a bond T3d OH
335 N NMe QIj a bond Me a bond NH S a bond T3e OH
336 N NMe QIj a bond Me a bond NH S a bond T3f OH 337 N NMe QIj a bond Me a bond NH S a bond T3g OH
338 N NMe QIj a bond Me a bond NH S a bond T3h OH 339 N NMe QIj a bond Me a bond NH S a bond T3i OH
340 N NMe QIj a bond Me a bond NH S a bond T3j OH
341 N NMe QIj a bond Me a bond NH 0 NH T3a OH
342 N NMe QIj a bond Me a bond NH 0 NH T3b OH 343 N NMe QIj a bond Me a bond NH 0 NH T3c OH
344 N NMe QIj a bond Me a bond NH 0 NH T3d OH
345 N NMe QIj a bond Me a bond NH 0 NH T3e OH
346 N NMe QIj a bond Me a bond NH 0 NH T3f OH
347 N NMe QIj a bond Me a bond NH 0 NH T3g OH 348 N NMe QIj a bond Me a bond NH 0 NH T3h OH
349 N NMe QIj a bond Me a bond NH 0 NH T3i OH
350 N NMe QIj a bond Me a bond NH 0 NH T3j OH
351 N NMe QIj a bond Me a bond NH 0 a bond T3a OH
352 N NMe QIj a bond Me a bond NH 0 a bond T3b OH 353 N NMe QIj a bond Me a bond NH 0 a bond T3c OH
354 N NMe QIj a bond Me a bond NH 0 a bond T3d OH
355 N NMe QIj a bond Me a bond NH 0 a bond T3e OH
356 N NMe QIj a bond Me a bond NH 0 a bond T3f OH
357 N NMe QIj a bond Me a bond NH 0 a bond T3g OH 358 N NMe QIj a bond Me a bond NH 0 a bond T3h OH
359 N NMe QIj a bond Me a bond NH 0 a bond T3i OH
360 N NMe QIj a bond Me a bond NH 0 a bond T3j OH
361 N NMe QIj a bond H a bond NH S NH T3a OH
362 N NMe QIj a bond H a bond NH S NH T3b OH 363 N NMe QIj a bond H a bond NH S NH T3c OH
364 N NMe QIj a bond H a bond NH S NH T3d OH
365 N NMe QIj a bond H a bond NH S NH T3e OH
366 N NMe QIj a bond H a bond NH S NH T3f OH
367 N NMe QIj a bond H a bond NH S NH T3g OH 368 N NMe QIj a bond H a bond NH S NH T3h OH
369 N NMe QIj a bond H a bond NH S NH T3i OH
370 N NMe QIj a bond H a bond NH S NH T3j OH
371 N NMe QIj a bond H a bond NH S a bond T3a OH
372 N NMe QIj a bond H a bond NH S a bond T3b OH 373 N NMe QIj a bond H a bond NH S a bond T3c OH
374 N NMe QIj a bond H a bond NH S a bond T3d OH 375 N NMe QIj a bond H a bond NH S a bond T3e OH
376 N NMe QIj a bond H a bond NH S a bond T3f OH
377 N NMe QIj a bond H a bond NH S a bond T3g OH
378 N NMe QIj a bond H a bond NH S a bond T3h OH 379 N NMe QIj a bond H a bond NH S a bond T3i OH
380 N NMe QIj a bond H a bond NH S a bond T3j OH
381 N NMe QIj a bond H a bond NH 0 NH T3a OH
382 N NMe QIj a bond H a bond NH 0 NH T3b OH
383 N NMe QIj a bond H a bond NH 0 NH T3c OH 384 N NMe QIj a bond H a bond NH 0 NH T3d OH
385 N NMe QIj a bond H a bond NH 0 NH T3e OH
386 N NMe QIj a bond H a bond NH 0 NH T3f OH
387 N NMe QIj a bond H a bond NH 0 NH T3g OH
388 N NMe QIj a bond H a bond NH 0 NH T3h OH 389 N NMe QIj a bond H a bond NH 0 NH T3i OH
390 N NMe QIj a bond H a bond NH 0 NH T3j OH
391 N NMe QIj a bond H a bond NH 0 a bond T3a OH
392 N NMe QIj a bond H a bond NH 0 a bond T3b OH
393 N NMe QIj a bond H a bond NH 0 a bond T3c OH 394 N NMe QIj a bond H a bond NH 0 a bond T3d OH
395 N NMe QIj a bond H a bond NH 0 a bond T3e OH
396 N NMe QIj a bond H a bond NH 0 a bond T3f OH
397 N NMe QIj a bond H a bond NH 0 a bond T3g OH
398 N NMe QIj a bond H a bond NH 0 a bond T3h OH 399 N NMe QIj a bond H a bond NH 0 a bond T3i OH
400 N NMe QIj a bond H a bond NH 0 a bond T3j OH
401 N S QIa a bond Me a bond NH S NH T3a OH
402 N S QIa a bond Me a bond NH S NH T3b OH
403 N S QIa a bond Me a bond NH S NH T3c OH 404 N S QIa a bond Me a bond NH S NH T3d OH
405 N S QIa a bond Me a bond NH S NH T3e OH
406 N S QIa a bond Me a bond NH S NH T3f OH
407 N S QIa a bond Me a bond NH S NH T3g OH
408 N S QIa a bond Me a bond NH S NH T3h OH 409 N S QIa a bond Me a bond NH S NH T3i OH
410 N S QIa a bond Me a bond NH S NH T3j OH 411 N S QIa a bond Me a bond NH S a bond T3a OH
412 N S QIa a bond Me a bond NH S a bond T3b OH
413 N S QIa a bond Me a bond NH S a bond T3c OH
414 N S QIa a bond Me a bond NH S a bond T3d OH
415 N S QIa a bond Me a bond NH S a bond T3e OH
416 N S QIa a bond Me a bond NH S a bond T3f OH
417 N S QIa a bond Me a bond NH S a bond T3g OH
418 N S QIa a bond Me a bond NH S a bond T3h OH
419 N S QIa a bond Me a bond NH S a bond T3i OH
420 N S QIa a bond Me a bond NH S a bond T3j OH
421 N S QIa a bond Me a bond NH 0 NH T3a OH
422 N S QIa a bond Me a bond NH 0 NH T3b OH
423 N S QIa a bond Me a bond NH 0 NH T3c OH
424 N S QIa a bond Me a bond NH 0 NH T3d OH
425 N S QIa a bond Me a bond NH 0 NH T3e OH
426 N S QIa a bond Me a bond NH 0 NH T3f OH
427 N S QIa a bond Me a bond NH 0 NH T3g OH
428 N S QIa a bond Me a bond NH 0 NH T3h OH
429 N S QIa a bond Me a bond NH 0 NH T3i OH
430 N S QIa a bond Me a bond NH 0 NH T3j OH
431 N S QIa a bond Me a bond NH 0 a bond T3a OH
432 N S QIa a bond Me a bond NH 0 a bond T3b OH
433 N S QIa a bond Me a bond NH 0 a bond T3c OH
434 N S QIa a bond Me a bond NH 0 a bond T3d OH
435 N S QIa a bond Me a bond NH 0 a bond T3e OH
436 N S QIa a bond Me a bond NH 0 a bond T3f OH
437 N S QIa a bond Me a bond NH 0 a bond T3g OH
438 N S QIa a bond Me a bond NH 0 a bond T3h OH
439 N S QIa a bond Me a bond NH 0 a bond T3i OH
440 N S QIa a bond Me a bond NH 0 a bond T3j OH
441 N S QIa a bond H a bond NH S NH T3a OH
442 N S QIa a bond H a bond NH S NH T3b OH
443 N S QIa a bond H a bond NH S NH T3c OH
444 N S QIa a bond H a bond NH S NH T3d OH
445 N S QIa a bond H a bond NH S NH T3e OH
446 N S QIa a bond H a bond NH S NH T3f OH 447 N S QIa a bond H a bond NH S NH T3g OH
448 N S QIa a bond H a bond NH S NH T3h OH
449 N S QIa a bond H a bond NH S NH T3i OH
450 N S QIa a bond H a bond NH S NH T3j OH
451 N S QIa a bond H a bond NH ' S a bond T3a OH
452 N S QIa a bond H a bond NH S a bond T3b OH
453 N S QIa a bond H a bond NH S a bond T3c OH
454 N S QIa a bond H a bond NH S a bond T3d OH
455 N S QIa a bond H a bond NH S a bond T3e OH
456 N S QIa a bond H a bond NH S a bond T3f OH
457 N S QIa a bond H a bond NH S a bond T3g OH
458 N S QIa a bond H a bond NH S a bond T3h OH
459 N S QIa a bond H a bond NH S a bond T3i OH
460 N S QIa a bond H a bond NH S a bond T3j OH
461 N S QIa a bond H a bond NH 0 NH T3a OH
462 N S QIa a bond H a bond NH 0 NH T3b OH
463 N S QIa a bond H a bond NH 0 NH T3c OH
464 N S QIa a bond H a bond NH 0 NH T3d OH
465 N S QIa a bond H a bond NH 0 NH T3e OH
466 N S QIa a bond H a bond NH 0 NH T3f OH
467 N S QIa a bond H a bond NH 0 NH T3g OH
468 N S QIa a bond H a bond NH 0 NH T3h OH
469 N S QIa a bond H a bond NH 0 NH T3i OH
470 N S QIa a bond H a bond NH 0 NH T3j OH
471 N S QIa a bond H a bond NH 0 a bond T3a OH
472 N S QIa a bond H a bond NH 0 a bond T3b OH
473 N S QIa a bond H a bond NH 0 a bond T3c OH
474 N S QIa a bond H a bond NH 0 a bond T3d OH
475 N S QIa a bond H a bond NH 0 a bond T3e OH
476 N S QIa a bond H a bond NH 0 a bond T3f OH
477 N S QIa a bond H a bond NH 0 a bond T3g OH
478 N S QIa a bond H a bond NH 0 a bond T3h OH
479 N S QIa a bond H a bond NH 0 a bond T3i OH
480 N S QIa a bond H a bond NH 0 a bond T3j OH
481 N S QIb a bond Me a bond NH S NH T3a OH
482 N S QIb a bond Me a bond NH S NH T3b OH 483 N S QIb a bond Me a bond NH S NH T3c OH
484 N S QIb a bond Me a bond NH S NH T3d OH
485 N S QIb a bond Me a bond NH S NH T3e OH
486 N S QIb a bond Me a bond NH S NH T3f OH
487 N S QIb a bond Me a bond NH S NH T3g OH
488 N S QIb a bond Me a bond NH S NH T3h OH
489 N S QIb a bond Me a bond NH S NH T3i OH
490 N S QIb a bond Me a bond NH S NH T3j OH
491 N S QIb a bond Me a bond NH S a bond T3a OH
492 N S QIb a bond Me a bond NH S a bond T3b OH
493 N S QIb a bond Me a bond NH S a bond T3c OH
494 N S QIb a bond Me a bond NH S a bond T3d OH
495 N S QIb a bond Me a bond NH S a bond T3e OH
496 N S QIb a bond Me a bond NH S a bond T3f OH
497 N S QIb a bond Me a bond NH S a bond T3g OH
498 N S QIb a bond Me a bond NH S a bond T3h OH
499 N S QIb a bond Me a bond NH S a bond T3i OH
500 N S QIb a bond Me a bond NH S a bond T3j OH
501 N S QIb a bond Me a bond NH 0 NH T3a OH
502 N S QIb a bond Me a bond NH 0 NH T3b OH
503 N S QIb a bond Me a bond NH 0 NH T3c OH
504 N S QIb a bond Me a bond NH 0 NH T3d OH
505 N S QIb a bond Me a bond NH 0 NH T3e OH
506 N S QIb a bond Me a bond NH 0 NH T3f OH
507 N S QIb a bond Me a bond NH 0 NH T3g OH
508 N S QIb a bond Me a bond NH 0 NH T3h OH
509 N S QIb a bond Me a bond NH 0 NH T3i OH
510 N S QIb a bond Me a bond NH 0 NH T3j OH
511 N S QIb a bond Me a bond NH 0 a bond T3a OH
512 N S QIb a bond Me a bond NH 0 a bond T3b OH
513 N S QIb a bond Me a bond NH 0 a bond T3c OH
514 N S QIb a bond Me a bond NH 0 a bond T3d OH
515 N S QIb a bond Me a bond NH 0 a bond T3e OH
516 .N S QIb a bond Me a bond NH 0 a bond T3f OH
517 N S QIb a bond Me a bond NH 0 a bond T3g OH
518 N S QIb a bond Me a bond NH 0 a bond T3h OH 519 N S QIb a bond Me a bond NH O0 aa bboonndd TT33ii O0H
520 N S QIb a bond Me a bond NH O 0 aa bboonndd . TT33jj O 0H
521 N S QIb a bond H a bond NH S S N NHH T T33aa O OHH
522 N S QIb a bond H a bond NH S S N NHH T T33bb O OHH
523 N S QIb a bond H a bond NH ' S S N NHH T T33cc O OHH
524 N S QIb a bond H a bond NH S S N NHH T T33dd O OHH
525 N S QIb a bond H a bond NH S S N NHH T T33ee O OHH
526 N S QIb a bond H a bond NH S S N NHH T T33ff O OHH
527 N S QIb a bond H a bond NH S S N NHH T T33gg O OHH
528 N S QIb a bond H a bond NH S NH T3h OH
529 N S QIb a bond H a bond NH S NH T3i OH
530 N S QIb a bond H a bond NH S NH T3j OH
531 N S QIb a bond H a bond NH S a bond T3a OH
532 N S QIb a bond H a bond NH S a bond T3b OH
533 N S QIb a bond H a bond NH S a bond T3c OH
534 N S QIb a bond H a bond NH S a bond T3d OH
535 N S QIb a bond H a bond NH S a bond T3e OH
536 N S QIb a bond H a bond NH S a bond T3f OH
537 N S QIb a bond H a bond NH S a bond T3g OH
538 N S QIb a bond H a bond NH S a bond T3h OH
539 N S QIb a bond H a bond NH S a bond T3i OH
540 N S QIb a bond H a bond NH S a bond T3j OH
541 N S QIb a bond H a bond NH 0 NH T3a OH
542 N S QIb a bond H a bond NH 0 NH T3b OH
543 N S QIb a bond H a bond NH 0 NH T3c OH
544 N S QIb a bond H a bond NH 0 NH T3d OH
545 N S QIb a bond H a bond NH 0 NH T3e OH
546 N S QIb a bond H a bond NH 0 NH T3f OH
547 N S QIb a bond H a bond NH 0 NH T3g OH
548 N S QIb a bond H a bond NH 0 NH T3h OH
549 N S QIb a bond H a bond NH 0 NH T3i OH
550 N S QIb a bond H a bond NH 0 NH T3j OH
551 N S QIb a bond H a bond NH 0 a bond T3a OH
552 N S QIb a bond H a bond NH 0 a bond T3b OH
553 N S QIb a bond H a bond NH 0 a bond T3c OH
554 N S QIb a bond H a bond NH 0 a bond T3d OH 555 N S QIb a bond H a bond NH 0 a I3ond T3e OH
556 N S QIb a bond H a bond NH 0 a 1 Dond T3f OH
557 N S QIb a bond H a bond NH 0 a 1 Dond T3g OH
558 N S QIb a bond H a bond NH 0 a 1 Dond T3h OH
559 N S QIb a bond H a bond NH ' 0 a 1 3ond T3i OH
560 N S QIb a bond H a bond NH 0 a 1 Dond T3j OH
561 N S QIc a bond Me a bond NH S NH T3a OH
562 N S QIc a bond Me a bond NH S NH T3b OH
563 N S QIc a bond Me a bond NH S NH T3c OH
564 N S QIc a bond Me a bond NH S NH T3d OH
565 N S QIc a bond Me a bond NH S NH T3e OH
566 N S QIc a bond Me a bond NH S NH T3f OH
567 N S QIc a bond Me a bond NH S NH T3g OH
568 N S QIc a bond Me a bond NH S NH T3h OH
569 N S QIc a bond Me a bond NH S NH T3i OH
570 N S QIc a bond Me a bond NH S NH T3j OH
571 N S QIc a bond Me a bond NH S a bond T3a OH
572 N S QIc a bond Me a bond NH S a bond T3b OH
573 N S QIc a bond Me a bond NH S a bond T3c OH
574 N S QIc a bond Me a bond NH S a bond T3d OH
575 N S QIc a bond Me a bond NH S a bond T3e OH
576 N S QIc a bond Me a bond NH S a bond T3f OH
577 N S QIc a bond Me a bond NH S a bond T3g OH
578 N S QIc a bond Me a bond NH S a bond T3h OH
579 N S QIc a bond Me a bond NH S a bond T3i OH
580 N S QIc a bond Me a bond NH S a bond T3j OH
581 N S QIc a bond Me a bond NH 0 NH T3a OH
582 N S QIc a bond Me a bond NH 0 NH T3b OH
583 N S QIc a bond Me a bond NH 0 NH T3c OH
584 N S QIc a bond Me a bond NH 0 NH T3d OH
585 N S QIc a bond Me a bond NH 0 NH T3e OH
586 N S QIc a bond Me a bond NH 0 NH T3f OH
587 N S QIc a bond Me a bond NH 0 NH T3g OH
588 N S QIc a bond Me a bond NH 0 NH T3h OH
589 N S QIc a bond Me a bond NH 0 NH T3i OH
590 N S QIc a bond Me a bond NH 0 NH T3i OH 591 N S QIc a bond Me a bond NH 0 a bond T3a OH
592 N S QIc a bond Me a bond NH 0 a bond T3b OH
593 N S QIc a bond Me a bond NH 0 a bond T3c OH
594 N S QIc a bond Me a bond NH 0 a bond T3d OH 595 N S QIc a bond Me a bond NH 0 a bond T3e OH
596 N S QIc a bond Me a bond NH 0 a bond T3f OH
597 N S QIc a bond Me a bond NH 0 a bond T3g OH
598 N S QIc a bond Me a bond NH 0 a bond T3h OH
599 N S QIc a bond Me a bond NH 0 a bond T3i OH 600 N S QIc a bond Me a bond NH 0 a bond T3j OH
601 N S QIc a bond H a bond NH S NH T3a OH
602 N S QIc a bond H a bond NH S NH T3b OH
603 N S QIc a bond H a bond NH S NH T3c OH
604 N S QIc a bond H a bond NH S NH T3d OH 605 N S QIc a bond H a bond NH S NH T3e OH
606 N S QIc a bond H a bond NH S NH T3f OH
607 N S QIc a bond H a bond NH S NH T3g OH
608 N S QIc a bond H a bond NH S NH T3h OH
609 N S QIc a bond H a bond NH S NH T3i OH 610 N S QIc a bond H a bond NH S NH T3j OH
611 N S QIc a bond H a bond NH S a bond T3a OH
612 N S QIc a bond H a bond NH S a bond T3b OH
613 N S QIc a bond H a bond NH S a bond T3c OH
614 N S QIc a bond H a bond NH S a bond T3d OH 615 N S QIc a bond H a bond NH S a bond T3e OH
616 N S QIc a bond H a bond NH S a bond T3f OH
617 N S QIc a bond H a bond NH S a bond T3g OH
618 N S QIc a bond H a bond NH S a bond T3h OH
619 N S QIc a bond H a bond NH S a bond T3i OH 620 N S QIc a bond H a bond NH S a bond T3j OH
621 N S QIc a bond H a bond NH 0 NH T3a OH
622 N S QIc a bond H a bond NH 0 NH T3b OH
623 N S QIc a bond H a bond NH 0 NH T3c OH
624 N S QIc a bond H a bond NH 0 NH T3d OH 625 N S QIc a bond H a bond NH 0 NH T3e OH
626 N S QIc a bond H a bond NH 0 NH T3f OH 627 N S QIc a bond H a bond NH 0 NH T3g OH
628 N S QIc a bond H a bond NH 0 NH T3h OH
629 N S QIc a bond H a bond NH 0 NH T3i OH
630 N S QIc a bond H a bond NH 0 NH T3j OH 631 N S QIc a bond H a bond NH O a bond T3a OH
632 N S QIc a bond H a bond NH 0 a bond T3b OH
633 N S QIc a bond H a bond NH 0 a bond T3c OH
634 N S QIc a bond H a bond NH 0 a bond T3d OH
635 N S QIc a bond H a bond NH 0 a bond T3e OH 636 N S QIc a bond H a bond NH 0 a bond T3f OH
637 N S QIc a bond H a bond NH 0 a bond T3g OH
638 N S QIc a bond H a bond NH 0 a bond T3h OH
639 N S QIc a bond H a bond NH 0 a bond T3i OH
640 N S QIc a bond H a bond NH 0 a bond T3j OH 641 N S QIi a bond Me a bond NH S NH T3a OH
642 N S QIi a bond Me a bond NH S NH T3b OH
643 N S QIi a bond Me a bond NH S NH T3c OH
644 N S QIi a bond Me a bond NH S NH T3d OH
645 N S QIi a bond Me a bond NH S NH T3e OH 646 N S QIi a bond Me a bond NH S NH T3f OH
647 N S QIi a bond Me a bond NH S NH T3g OH
648 N S QIi a bond Me a bond NH S NH T3h OH
649 N S QIi a bond Me a bond NH S NH T3i OH
650 N S QIi a bond Me a bond NH S NH T3j OH 651 N S QIi a bond Me a bond NH S a bond T3a OH
652 N S QIi a bond Me a bond NH S a bond T3b OH
653 N S QIi a bond Me a bond NH S a bond T3c OH
654 N S QIi a bond Me a bond NH S a bond T3d OH
655 N S QIi a bond Me a bond NH S a bond T3e OH 656 N S QIi a bond Me a bond NH S a bond T3f OH
657 N S QIi a bond Me a bond NH S a bond T3g OH
658 N S QIi a bond Me a bond NH S a bond T3h OH
659 N S QIi a bond Me a bond NH S a bond T3i OH
660 N S QIi a bond Me a bond NH S a bond T3j OH 661 N S QIi a bond Me a bond NH 0 NH T3a OH
662 N S QIi a bond Me a bond NH 0 NH T3b OH 663 N S QIi a bond Me a bond NH 0 { T3c OH
664 N S QIi a bond Me a bond NH 0 I T3d OH
665 N S QIi a bond Me a bond NH 0 M I T3e OH
666 N S QIi a bond Me a bond NH 0 M I T3f OH
667 N S QIi a bond Me a bond NH 0 M I T3g OH
668 N S QIi a bond Me a bond NH 0 M I T3h OH
669 N S QIi a bond Me a bond NH 0 M 1 T TTO3i* OH
670 N S QIi a bond Me a bond NH 0 NI I T3j OH
671 N S QIi a bond Me a bond NH 0 a bond T3a OH
672 N S QIi a bond Me a bond NH 0 a bond T3b OH
673 N S QIi a bond Me a bond NH 0 a bond T3c OH
674 N S QIi a bond Me a bond NH 0 a bond T3d OH
675 N S QIi a bond Me a bond NH 0 a bond T3e OH
676 N S QIi a bond Me a bond NH 0 a bond T3f OH
677 N S QIi a bond Me a bond NH 0 a bond T3g OH
678 N S QIi a bond Me a bond NH 0 a bond T3h OH
679 N S QIi a bond Me a bond NH 0 a bond T3i OH
680 N S QIi a bond Me a bond NH 0 a bond T3j OH
681 N S QIi a bond H a bond NH S NH T3a OH
682 N S QIi a bond H a bond NH S NH T3b OH
683 N S QIi a bond H a bond NH S NH T3c OH
684 N S QIi a bond H a bond NH S NH T3d OH
685 N S QIi a bond H a bond NH S NH T3e OH
686 N S QIi a bond H a bond NH S NH T3f OH
687 N S QIi a bond H a bond NH S NH T3g OH
688 N S QIi a bond H a bond NH S NH T3h OH
689 N S QIi a bond H a bond NH S NH T3i OH
690 N S QIi a bond H a bond NH S NH T3j OH
691 N S QIi a bond H a bond NH S a bond T3a OH
692 N S QIi a bond H a bond NH S a bond T3b OH
693 N S QIi a bond H a bond NH S a bond T3c OH
694 N S QIi a bond H a bond NH S a bond T3d OH
695 N S QIi a bond H a bond NH S a bond T3e OH
696 N S QIi a bond H a bond NH S a bond T3f OH
697 N S QIi a bond H a bond NH S a bond T3g OH
698 N S QIi a bond H a bond NH S a bond T3h OH 699 N S QIi a bond H a bond NH S a bond T3i OH
700 N S QIi a bond H a bond NH S a bond T3j OH
701 N S QIi a bond H a bond NH 0 NH T3a OH
702 N S QIi a bond H a bond NH 0 NH T3b OH 703 N S QIi a bond H a bond NH "θ NH T3c OH
704 N S QIi a bond H a bond NH 0 NH T3d OH
705 N S QIi a bond H a bond NH 0 NH T3e OH
706 N S QIi a bond H a bond NH 0 NH T3f OH
707 N S QIi a bond H a bond NH 0 NH T3g OH 708 N S QIi a bond H a bond NH 0 NH T3h OH
709 N S QIi a bond H a bond NH 0 NH T3i OH
710 N S QIi a bond H a bond NH 0 NH T3j OH
711 N S QIi a bond H a bond NH 0 a bond T3a OH
712 N S QIi a bond H a bond NH 0 a bond T3b OH 713 N S QIi a bond H a bond NH 0 a bond T3c OH
714 N S QIi a bond H a bond NH 0 a bond T3d OH
715 N S QIi a bond H a bond NH 0 a bond T3e OH
716 N S QIi a bond H a bond NH 0 a bond T3f OH
717 N S QIi a bond H a bond NH 0 a bond T3g OH 718 N S QIi a bond H a bond NH 0 a bond T3h OH
719 N S QIi a bond H a bond NH 0 a bond T3i OH
720 N S QIi a bond H a bond NH 0 a bond T3j OH
721 N S QIj a bond Me a bond NH S NH T3a OH
722 N S QIj a bond Me a bond NH S NH T3b OH 723 N S QIj a bond Me a bond NH S NH T3c OH
724 N S QIj a bond Me a bond NH S NH T3d OH
725 N S QIj a bond Me a bond NH S NH T3e OH
726 N S QIj a bond Me a bond NH S NH T3f OH
727 N S QIj a bond Me. a bond NH S NH T3g OH 728 N S QIj a bond Me a bond NH S NH T3h OH
729 N S QIj a bond Me a bond NH S NH T3i OH
730 N S QIj a bond Me a bond NH S NH T3j OH
731 N S QIj a bond Me a bond NH S a bond T3a OH
732 N S QIj a bond Me a bond NH S a bond T3b OH 733 N S QIj a bond Me a bond NH S a bond T3c OH
734 N S QIj a bond Me a bond NH S a bond ,T3d OH 735 N S QIj a bond Me a bond NH S a bond T3e OH
736 N S QIj a bond Me a bond NH S a bond T3f OH
737 N S QIj a bond Me a bond NH S a bond T3g OH
738 N S QIj a bond Me a bond NH S a bond T3h OH
739 N S QIj a bond Me a bond NH' S a bond T3i OH
740 N S QIj a bond Me a bond NH S a bond T3j OH
741 N S QIj a bond Me a bond NH 0 NH T3a OH
742 N S QIj a bond Me a bond NH 0 NH T3b OH
743 N S QIj a bond Me a bond NH 0 NH T3c OH
744 N S QIj a bond Me a bond NH 0 NH T3d OH
745 N S QIj a bond Me a bond NH 0 NH T3e OH
746 N S QIj a bond Me a bond NH 0 NH T3f OH
747 N S QIj a bond Me a bond NH 0 NH T3g OH
748 N S Qij a bond Me a bond NH 0 NH T3h OH
749 N S QIj a bond Me a bond NH 0 NH T3i OH
750 N S QIj a bond Me a bond NH 0 NH T3j OH
751 N S Qij a bond Me a bond NH 0 a bond T3a OH
752 N S Qij a bond Me a bond NH 0 a bond T3b OH
753 N S Qij a bond Me a bond NH 0 a bond T3c OH
754 N S Qij a bond Me a bond NH 0 a bond T3d OH
755 N S Qij a bond Me a bond NH 0 a bond T3e OH
756 N S Qij a bond Me a bond NH 0 a bond T3f OH
757 N S Qij a bond Me a bond NH 0 a bond T3g OH
758 N S Qij a bond Me a bond NH 0 a bond T3h OH
759 N S Qij a bond Me a bond NH 0 a bond T3i OH
760 N S Qij a bond Me a bond NH 0 a bond T3j OH
761 N S Qij a bond H a bond NH S NH T3a OH
762 N S Qij a bond H a bond NH S NH T3b OH
763 N S Qij a bond H a bond NH S NH T3c OH
764 N S Qij a bond H a bond NH S NH T3d OH
765 N S Qij a bond H a bond NH S NH T3e OH
766 N S Qij a bond H a bond NH S NH T3f OH
767 N S Qij a bond H a bond NH S NH T3g OH
768 N S Qij a bond H a bond NH S NH T3h OH
769 N S Qij a bond H a bond NH S NH T3i OH
770 N S Qij a bond H a bond NH S NH T3j OH 771 N S QIj a bond H a bond NH S a bond T3a OH
772 N S QIj a bond H a bond NH S a bond T3b OH
773 N S QIj a bond H a bond NH S a bond T3c OH
774 N S QIj a bond H a bond NH S a bond T3d OH 775 N S QIj a bond H a bond NH 'S a bond T3e OH
776 N S QIj a bond H a bond NH S a bond T3f OH
777 N S QIj a bond H a bond NH S a bond T3g OH
778 N S QIj a bond H a bond NH S a bond T3h OH
779 N S QIj a bond H a bond NH S a bond T3i OH 780 N S QIj a bond H a bond NH S a bond T3j OH
781 N S QIj a bond H a bond NH 0 NH T3a OH
782 N S QIj a bond H a bond NH 0 NH T3b OH
783 N S QIj a bond H a bond NH 0 NH T3c OH
784 N S QIj a bond H a bond NH 0 NH T3d OH 785 N S QIj a bond H a bond NH 0 NH T3e OH
786 N S QIj a bond H a bond NH 0 NH T3f OH
787 N S QIj a bond H a bond NH 0 NH T3g OH
788 N S QIj a bond H a bond NH 0 NH T3h OH
789 N S QIj a bond H a bond NH 0 NH T3i OH 790 N S QIj a bond H a bond NH 0 NH T3j OH
791 N S QIj a bond H a bond NH 0 a bond T3a OH
792 N S QIj a bond H a bond NH 0 a bond T3b OH
793 N S QIj a bond H a bond NH 0 a bond T3c OH
794 N S QIj a bond H a bond NH 0 a bond T3d OH 795 N S QIj a bond H a bond NH 0 a bond T3e OH
796 N S QIj a bond H a bond NH 0 a bond T3f OH
797 N S QIj a bond H a bond NH 0 a bond T3g OH
798 N S QIj a bond H a bond NH 0 a bond T3h OH
799 N S QIj a bond H a bond NH 0 a bond T3i OH 800 N S QIj a bond H a bond NH 0 a bond T3j OH
801 N 0 QIa a bond Me a bond NH S NH T3a OH
802 N 0 QIa a bond Me a bond NH S NH T3b OH
803 N 0 QIa a bond Me a bond NH S NH T3c OH
804 N 0 QIa a bond Me a bond NH S NH T3d OH 805 N 0 QIa a bond Me a bond NH S NH T3e OH
806 N 0 QIa a bond Me a bond NH S NH T3f OH 807 N 0 QIa a bond Me a bond NH S NH T3g OH
808 N 0 QIa a bond Me a bond NH S NH T3h OH
809 N 0 QIa a bond Me a bond NH S NH T3i OH
810 N 0 QIa a bond Me a bond NH S NH T3j OH 811 N 0 QIa a bond Me a bond NH" S a bond T3a OH
812 N 0 QIa a bond Me a bond NH S a bond T3b OH
813 N 0 QIa a bond Me a bond NH S a bond T3c OH
814 N 0 QIa a bond Me a bond NH S a bond T3d OH
815 N 0 QIa a bond Me a bond NH S a bond T3e OH 816 N 0 QIa a bond Me a bond NH S a bond T3f OH
817 N 0 QIa a bond Me a bond NH S a bond T3g OH
818 N 0 QIa a bond Me a bond NH S a bond T3h OH
819 N 0 QIa a bond Me a bond NH S a bond T3i OH
820 N 0 QIa a bond Me a bond NH S a bond T3j OH 821 N 0 QIa a bond Me a bond NH 0 NH T3a OH
822 N 0 QIa a bond Me a bond NH 0 NH T3b OH
823 N 0 QIa a bond Me a bond NH 0 NH T3c OH
824 N 0 QIa a bond Me a bond NH 0 NH T3d OH
825 N 0 QIa a bond Me a bond NH 0 NH T3e OH 826 N 0 QIa a bond Me a bond NH 0 NH T3f OH
827 N 0 QIa a bond Me a bond NH 0 NH T3g OH
828 N 0 QIa a bond Me a bond NH 0 NH T3h OH
829 N 0 QIa a bond Me a bond NH 0 NH T3i OH
830 N 0 QIa a bond Me a bond NH 0 NH T3j OH 831 N 0 QIa a bond Me a bond NH 0 a bond T3a OH
832 N 0 QIa a bond Me a bond NH 0 a bond T3b OH
833 N 0 QIa a bond Me a bond NH 0 a bond T3c OH
834 N 0 QIa a bond Me a bond NH 0 a bond T3d OH
835 N 0 QIa a bond Me a bond NH 0 a bond T3e OH 836 N 0 QIa a bond Me a bond NH 0 a bond T3f OH
837 N 0 QIa a bond Me a bond NH 0 a bond T3g OH
838 N 0 QIa a bond Me a bond NH 0 a bond T3h OH
839 N 0 QIa a bond Me a bond NH 0 a bond T3i OH
840 N 0 QIa a bond Me a bond NH 0 a bond T3j OH 841 N 0 QIa a bond H a bond NH S NH T3a OH
842 N 0 QIa a bond H a bond NH S NH T3b OH 843 N 0 QIa a bond H a bond NH S NH T3c OH
844 N 0 QIa a bond H a bond NH S NH T3d OH
845 N 0 QIa a bond H a bond NH S NH T3e OH
846 N 0 QIa a bond H a bond NH S S N NHH T T33ff O OHH
847 N 0 QIa a bond H a bond NH ' Ss N NHH T T33gg O OHH
848 N 0 QIa a bond H a bond NH S S N NHH T T33hh O OHH
849 N 0 QIa a bond H a bond NH S S N NHH T T33ii O OHH
850 N 0 QIa a bond H a bond NH S S N NHH T T33jj O OHH
851 N 0 QIa a bond H a bond NH S a bond T3a OH
852 N 0 QIa a bond H a bond NH S a bond T3b OH
853 N 0 QIa a bond H a bond NH S a bond T3c OH
854 N 0 QIa a bond H a bond NH S a bond T3d OH
855 N 0 QIa a bond H a bond NH S a bond T3e OH
856 N 0 QIa a bond H a bond NH S a bond T3f OH
857 N 0 QIa a bond H a bond NH S a bond T3g OH
858 N 0 QIa a bond H a bond NH S a bond T3h OH
859 N 0 QIa a bond H a bond NH S a bond T3i OH
860 N 0 QIa a bond H a bond NH S a bond T3j OH
861 N 0 QIa a bond H a bond NH 0 NH T3a OH
862 N 0 QIa a bond H a bond NH 0 NH T3b OH
863 N 0 QIa a bond H a bond NH 0 NH T3c OH
864 N 0 QIa a bond H a bond NH 0 NH T3d OH
865 N 0 QIa a bond H a bond NH 0 NH T3e OH
866 N 0 QIa a bond H a bond NH 0 NH T3f OH
867 N 0 QIa a bond H a bond NH 0 NH T3g OH
868 N 0 QIa a bond H a bond NH 0 NH T3h OH
869 N 0 QIa a bond H a bond NH 0 NH T3i OH
870 N 0 QIa a bond H a bond NH 0 NH T3j OH
871 N 0 QIa a bond H a bond NH 0 a bond T3a OH
872 N 0 QIa a bond H a bond NH 0 a bond T3b OH
873 N 0 QIa a bond H a bond NH 0 a bond T3c OH
874 N 0 QIa a bond H a bond NH 0 a bond T3d OH
875 N 0 QIa a bond H a bond NH 0 a bond T3e OH
876 N 0 QIa a bond H a bond NH 0 a bond T3f OH
877 N 0 QIa a bond H a bond NH 0 a bond T3g OH
878 N 0 QIa a bond H a bond NH 0 a bond T3h OH 879 N 0 QIa a bond H a bond NH 0 a 1jond T3i OH
880 N 0 QIa a bond H a bond NH 0 a t )ond T3j OH
881 N 0 QIb a bond Me a bond NH S NH T3a OH
882 N 0 QIb a bond Me a bond NH S NH T3b OH
883 N 0 QIb a bond Me a bond NH S NH T3c OH
884 N 0 QIb a bond Me a bond NH S NH T3d OH
885 N 0 QIb a bond Me a bond NH S NH T3e OH
886 N 0 QIb a bond Me a bond NH S NH T3f OH
887 N 0 QIb a bond Me a bond NH S NH T3g OH
888 N 0 QIb a bond Me a bond NH S NH T3h OH
889 N 0 QIb a bond Me a bond NH S NH T3i OH
890 N 0 QIb a bond Me a bond NH S NH T3j OH
891 N 0 QIb a bond Me a bond NH S a bond T3a OH
892 N 0 QIb a bond Me a bond NH S a bond T3b OH
893 N 0 QIb a bond Me a bond NH S a bond T3c OH
894 N 0 QIb a bond Me a bond NH S a bond T3d OH
895 N 0 QIb a bond Me a bond NH S a bond T3e OH
896 N 0 QIb a bond Me a bond NH S a bond T3f OH
897 N 0 QIb a bond Me a bond NH S a bond T3g OH
898 N 0 QIb a bond Me a bond NH S a bond T3h OH
899 N 0 QIb a bond Me a bond NH S a bond T3i OH
900 N 0 QIb a bond Me a bond NH S a bond T3j OH
901 N 0 QIb a bond Me a bond NH 0 NH T3a OH
902 N 0 QIb a bond Me a bond NH 0 NH T3b OH
903 N 0 QIb a bond Me a bond NH 0 NH T3c OH
904 N 0 QIb a bond Me a bond NH 0 NH T3d OH
905 N 0 QIb a bond Me a bond NH 0 NH T3e OH
906 N 0 QIb a bond Me a bond NH 0 NH T3f OH
907 N 0 QIb a bond Me a bond NH 0 NH T3g OH 908 N 0 QIb a bond Me a bond NH 0 NH T3h OH
909 N 0 QIb a bond Me a bond NH 0 NH T3i OH
910 N 0 QIb a bond Me a bond NH 0 NH T3j OH
911 N 0 QIb a bond Me a bond NH 0 a bond T3a OH
912 N 0 QIb a bond Me a bond NH 0 a bond T3b OH 913 N 0 QIb a bond Me a bond NH 0 a bond T3c OH
914 N 0 QIb a bond Me a bond NH 0 a bond T3d OH 915 N 0 QIb a bond Me a bond NH 0 a bond T3e OH
916 N 0 QIb a bond Me a bond NH 0 a bond T3f OH
917 N 0 QIb a bond Me a bond NH 0 a bond T3g OH
918 N 0 QIb a bond Me a bond NH 0 a bond T3h OH 919 N 0 QIb a bond Me a bond NH 0 a bond T3i OH
920 N 0 QIb a bond Me a bond NH 0 a bond T3j OH
921 N 0 QIb a bond H a bond NH S NH T3a OH
922 N 0 QIb a bond H a bond NH S NH T3b OH
923 N 0 QIb a bond H a bond NH S NH T3c OH 924 N 0 QIb a bond H a bond NH S NH T3d OH
925 N 0 QIb a bond H a bond NH S NH T3e OH
926 N 0 QIb a bond H a bond NH S NH T3f OH
927 N 0 QIb a bond H a bond NH S NH T3g OH
928 N 0 QIb a bond H a bond NH S NH T3h OH 929 N 0 QIb a bond H a bond NH S NH T3i OH
930 N 0 QIb a bond H a bond NH S NH T3j OH
931 N 0 QIb a bond H a bond NH S a bond T3a OH
932 N 0 QIb a bond H a bond NH S a bond T3b OH
933 N 0 QIb a bond H a bond NH S a bond T3c OH 934 N 0 QIb a bond H a bond NH S a bond T3d OH
935 N 0 QIb a bond H a bond NH S a bond T3e OH
936 N 0 QIb a bond H a bond NH S a bond T3f OH
937 N 0 QIb a bond H a bond NH S a bond T3g OH
938 N 0 QIb a bond H a bond NH S a bond T3h OH 939 N 0 QIb a bond H a bond NH S a bond T3i OH
940 N 0 QIb a bond H a bond NH S a bond T3j OH
941 N 0 QIb a bond H a bond NH 0 NH T3a OH
942 N 0 QIb a bond H a bond NH 0 NH T3b OH
943 N 0 QIb a bond H a bond NH 0 NH T3c OH 944 N 0 QIb a bond H a bond NH 0 NH T3d OH
945 N 0 QIb a bond H a bond NH 0 NH T3e OH
946 N 0 QIb a bond H a bond NH 0 NH T3f OH
947 N 0 QIb a bond H a bond NH 0 NH T3g OH
948 N 0 QIb a bond H a bond NH 0 NH T3h OH 949 N 0 QIb a bond H a bond NH 0 NH T3i OH
950 N 0 QIb a bond H a bond NH 0 NH T3j OH 951 N 0 QIb a bond H a bond NH 0 a bond T3a OH
952 N 0 QIb a bond H a bond NH 0 a bond T3b OH
953 N 0 QIb a bond H a bond NH 0 a bond T3c OH
954 N 0 QIb a bond H a bond NH 0 a bond T3d OH
955 N 0 QIb a bond H a bond NH O a bond T3e OH
956 N 0 QIb a bond H a bond NH 0 a bond T3f OH
957 N 0 QIb a bond H a bond NH 0 a bond T3g OH
958 N 0 QIb a bond H a bond NH 0 a bond T3h OH
959 N 0 QIb a bond H a bond NH 0 a bond T3i OH 960 N 0 QIb a bond H a bond NH 0 a bond T3j OH
961 N 0 QIc a bond Me a bond NH S NH T3a OH
962 N 0 QIc a bond Me a bond NH S NH T3b OH
963 N 0 QIc a bond Me a bond NH S NH T3c OH
964 N 0 QIc a bond Me a bond NH S NH T3d OH
965 N 0 QIc a bond Me a bond NH S NH T3e OH
966 N 0 QIc a bond Me a bond NH S NH T3f OH
967 N 0 QIc a bond Me a bond NH S NH T3g OH
968 N 0 QIc a bond Me a bond NH S NH T3h OH
969 N 0 QIc a bond Me a bond NH S NH T3i OH
970 N 0 QIc a bond Me a bond NH S NH T3j OH
971 N 0 QIc a bond Me a bond NH S a bond T3a OH
972 N 0 QIc a bond Me a bond NH S a bond T3b OH
973 N 0 QIc a bond Me a bond NH S a bond T3c OH
974 N 0 QIc a bond Me a bond NH S a bond T3d OH
975 N 0 QIc a bond Me a bond NH S a bond T3e OH
976 N 0 QIc a bond Me a bond NH S a bond T3f OH
977 N 0 QIc a bond Me a bond NH S a bond T3g OH
978 N 0 QIc a bond Me a bond NH S a bond T3h OH
979 N 0 QIc a bond Me a bond NH S a bond T3i OH
980 N 0 QIc a bond Me a bond NH S a bond T3j OH
981 N 0 QIc a bond Me a bond NH 0 NH T3a OH
982 N 0 QIc a bond Me a bond NH 0 NH T3b OH
983 N 0 QIc a bond Me a bond NH 0 NH T3c OH
984 N 0 QIc a bond Me a bond NH 0 NH T3d OH
985 N 0 QIc a bond Me a bond NH 0 NH T3e OH
986 N 0 QIc a bond Me a bond NH 0 NH T3f OH 987 N 0 QIc a bond Me a bond NH 0 NH T3g OH
988 N 0 QIc a bond Me a bond NH 0 NH T3h OH
989 N 0 QIc a bond Me a bond NH 0 NH T3i OH
990 N 0 QIc a bond Me a bond NH 0 NH T3j OH 991 N 0 QIc a bond Me a bond NH* 0 a bond T3a OH
992 N 0 QIc a bond Me a bond NH 0 a bond T3b OH
993 N 0 QIc a bond Me a bond NH 0 a bond T3c OH
994 N 0 QIc a bond Me a bond NH 0 a bond T3d OH
995 N 0 QIc a bond Me a bond NH 0 a bond T3e OH 996 N 0 QIc a bond Me a bond NH 0 a bond T3f OH
997 N 0 QIc a bond Me a bond NH 0 a bond T3g OH
998 N 0 QIc a bond Me a bond NH 0 a bond T3h OH
999 N 0 QIc a bond Me a bond NH 0 a bond T3i OH
1000 N 0 QIc a bond Me a bond NH 0 a bond T3j OH 1001 N 0 QIc a bond H a bond NH S NH T3a OH
1002 N 0 QIc a bond H a bond NH S NH T3b OH
1003 N 0 QIc a bond H a bond NH S NH T3c OH
1004 N 0 QIc a bond H a bond NH S NH T3d OH
1005 N 0 QIc a bond H a bond H S NH T3e OH 1006 N 0 QIc a bond H a bond NH S NH T3f OH
1007 N 0 QIc a bond H a bond NH S NH T3g OH
1008 N 0 QIc a bond H a bond NH S NH T3h OH
1009 N 0 QIc a bond H a bond NH S NH T3i OH
1010 N 0 QIc a bond H a bond NH S NH T3j OH 1011 N 0 QIc a bond H a bond NH S a bond T3a OH
1012 N 0 QIc a bond H a bond NH S a bond T3b OH
1013 N 0 QIc a bond H a bond NH S a bond T3c OH
1014 N 0 QIc a bond H a bond NH S a bond T3d OH
1015 N 0 QIc a bond H a bond NH S a bond T3e OH 1016 N 0 QIc a bond H a bond NH S a bond T3f OH
1017 N 0 QIc a bond H a bond NH S a bond T3g OH
1018 N 0 QIc a bond H a bond NH S a bond T3h OH
1019 N 0 QIc a bond H a bond NH S a bond T3i OH
1020 N 0 QIc a bond H a bond NH S a bond T3j OH 1021 N 0 QIc a bond H a bond NH 0 H T3a OH
1022 N 0 QIc a bond H a bond NH 0 NH T3b OH 1023 N 0 QIc a bond H a bond NH 0 NH T3c OH
1024 N 0 QIc a bond H a bond NH 0 NH T3d OH
1025 N 0 QIc a bond H a bond NH 0 NH T3e OH
1026 N 0 QIc a bond H a bond NH 0 NH T3f OH 1027 N 0 QIc a bond H a bond NH 0 NH T3g OH
1028 N 0 QIc a bond H a bond NH 0 NH T3h OH
1029 N 0 QIc a bond H a bond NH 0 NH T3i OH
1030 N 0 QIc a bond H a bond NH 0 NH T3j OH
1031 N 0 QIc a bond H a bond NH 0 a bond T3a OH 1032 N 0 QIc a bond H a bond NH 0 a bond T3b OH
1033 N 0 QIc a bond H a bond NH 0 a bond T3c OH
1034 N 0 QIc a bond H a bond NH 0 a bond T3d OH
1035 N 0 QIc a bond H a bond NH 0 a bond T3e OH
1036 N 0 QIc a bond H a bond NH 0 a bond T3f OH 1037 N 0 QIc a bond H a bond NH 0 a bond T3g OH
1038 N 0 QIc a bond H a bond NH 0 a bond T3h OH
1039 N 0 QIc a bond H a bond NH 0 a bond T3i OH
1040 N 0 QIc a bond H a bond NH 0 a bond T3j OH
1041 N 0 QIi a bond Me a bond NH S NH T3a OH 1042 N 0 QIi a bond Me a bond NH S NH T3b OH
1043 N 0 QIi a bond Me a bond NH S NH T3c OH
1044 N 0 QIi a bond Me a bond NH S NH T3d OH
1045 N 0 QIi a bond Me a bond NH S NH T3e OH
1046 N 0 QIi a bond Me a bond NH S NH T3f OH 1047 N 0 QIi a bond Me a bond NH S NH T3g OH
1048 N 0 QIi a bond Me a bond NH S NH T3h OH
1049 N 0 QIi a bond Me a bond NH S NH T3i OH
1050 N 0 QIi a bond Me a bond NH S NH T3j OH
1051 N 0 QIi a bond Me a bond NH S a bond T3a OH 1052 N 0 QIi a bond Me a bond NH S a bond T3b OH
1053 N 0 QIi a bond Me a bond NH S a bond T3c OH
1054 N 0 QIi a bond Me a bond NH S a bond T3d OH
1055 N 0 QIi a bond Me a bond NH S a bond T3e OH
1056 N 0 QIi a bond Me a bond NH S a bond T3f OH 1057 N 0 QIi a bond Me a bond NH S a bond T3g OH
1058 N 0 QIi a bond Me a bond NH S a bond T3h OH 1059 N 0 QIi a bond Me a bond NH S a bond T3i OH
1060 N 0 QIi a bond Me a bond NH S a bond T3j OH
1061 N 0 QIi a bond Me a bond NH 0 NH T3a OH
1062 N 0 QIi a bond Me a bond NH 0 NH T3b OH 1063 N 0 QIi a bond Me a bond NH 0 NH T3c OH
1064 N 0 QIi a bond Me a bond NH 0 NH T3d OH
1065 N 0 QIi a bond Me a bond NH 0 NH T3e OH
1066 N 0 QIi a bond Me a bond NH 0 NH T3f OH
1067 N 0 QIi a bond Me a bond NH 0 NH T3g OH 1068 N 0 QIi a bond Me a bond NH 0 NH T3h OH
1069 N 0 QIi a bond Me a bond NH 0 NH T3i OH
1070 N 0 QIi a bond Me a bond NH 0 NH T3j OH
1071 N 0 QIi a bond Me a bond NH 0 a bond T3a OH
1072 N 0 QIi a bond Me a bond NH 0 a bond T3b OH 1073 N 0 QIi a bond Me a bond NH 0 a bond T3c OH
1074 N 0 QIi a bond Me a bond NH 0 a bond T3d OH
1075 N 0 QIi a bond Me a bond NH 0 a bond T3e OH
1076 N 0 QIi a bond Me a bond NH 0 a bond T3f OH
1077 N 0 QIi a bond Me a bond NH 0 a bond T3g OH 1078 N 0 QIi a bond Me a bond NH 0 a bond T3h OH
1079 N 0 QIi a bond Me a bond NH 0 a bond T3i OH
1080 N 0 QIi a bond Me a bond NH 0 a bond T3j OH
1081 N 0 QIi a bond H a bond NH S NH T3a OH
1082 N 0 QIi a bond H a bond NH S NH T3b OH 1083 N 0 QIi a bond H a bond NH S NH T3c OH
1084 N 0 QIi a bond H a bond NH S NH T3d OH
1085 N 0 QIi a bond H a bond NH S NH T3e OH
1086 N 0 QIi a bond H a bond NH S NH T3f OH
1087 N 0 QIi a bond H a bond NH S NH T3g OH 1088 N 0 QIi a bond H a bond NH S NH T3h OH
1089 N 0 QIi a bond H a bond NH S NH T3i OH
1090 N 0 QIi a bond H a bond NH S NH T3j OH
1091 N 0 QIi a bond H a bond NH S a bond T3a OH
1092 N 0 QIi a bond H a bond NH S a bond T3b OH 1093 N 0 QIi a bond H a bond NH S a bond T3c OH
1094 N 0 QIi a bond H a bond NH S a bond T3d OH 1095 N 0 QIi a bond H a bond NH S a bond T3e OH
1096 N 0 QIi a bond H a bond NH S a bond T3f OH
1097 N 0 QIi a bond H a bond NH S a bond T3g OH
1098 N 0 QIi a bond H a bond NH S a bond T3h OH
1099 N 0 QIi a bond H a bond NH S a bond T3i OH
1100 N 0 QIi a bond H a bond NH S a bond T3j OH
1101 N 0 QIi a bond H a bond NH 0 NH T3a OH
1102 N 0 QIi a. bond H a bond NH 0 NH T3b OH
1103 N 0 QIi a bond H a bond NH 0 NH T3c OH
1104 N 0 QIi a bond H a bond NH 0 NH T3d OH
1105 N 0 QIi a bond H a bond NH 0 NH T3e OH
1106 N 0 QIi a bond H a bond NH 0 NH T3f OH
1107 N 0 QIi a bond H a bond NH 0 NH T3g OH
1108 N 0 QIi a bond H a bond NH 0 NH T3h OH
1109 N 0 QIi a bond H a bond NH 0 NH T3i OH
1110 N 0 QIi a bond H a bond NH 0 NH T3j OH
1111 N 0 QIi a bond H a bond NH 0 a bond T3a OH
1112 N 0 QIi a bond H a bond NH 0 a bond T3b OH
1113 N 0 QIi a bond H a bond NH 0 a bond T3c OH
1114 N 0 QIi a bond H a bond NH 0 a bond T3d OH
1115 N 0 QIi a bond H a bond NH 0 a bond T3e OH
1116 N 0 QIi a bond H a bond NH 0 a bond T3f OH
1117 N 0 QIi a bond H a bond NH 0 a bond T3g OH
1118 N 0 QIi a bond H a bond NH 0 a bond T3h OH
1119 N 0 QIi a bond H a bond NH 0 a bond T3i OH
1120 N 0 QIi a bond H a bond NH 0 a bond T3j OH
1121 N 0 QIj a bond Me a bond NH S NH T3a OH
1122 N 0 QIj a bond Me a bond NH S NH T3b OH
1123 N 0 QIj a bond Me a bond NH S NH T3c OH
1124 N 0 QIj a bond Me a bond NH S NH T3d OH
1125 N 0 Qij a bond Me a bond NH S NH T3e OH
1126 N 0 QIj a bond Me a bond NH S NH T3f OH
1127 N 0 Qij a bond Me a bond NH S NH T3g OH
1128 N 0 QIj a bond Me a bond NH S NH T3h OH
1129 N 0 Qij a bond Me a bond NH S NH T3i OH
1130 N 0 Qij a bond Me a bond NH S NH T3j OH 1131 N 0 QIj a bond Me a bond NH S a bond T3a OH
1132 N 0 QIj a bond Me a bond NH S a bond T3b OH
1133 N 0 QIj a bond Me a bond NH S a bond T3c OH
1134 N 0 QIj a bond Me a bond NH S a bond T3d OH 1135 N 0 QIj a bond Me a bond NH S a bond T3e OH
1136 N 0 QIj a bond Me a bond NH S a bond T3f OH
1137 N 0 QIj a bond Me a bond NH S a bond T3g OH
1138 N 0 QIj a bond Me a bond NH S a bond T3h OH
1139 N 0 QIj a bond Me a bond NH S a bond T3i OH 1140 N 0 QIj a bond Me a bond NH S a bond T3j OH
1141 N 0 QIj a bond Me a bond NH 0 NH T3a OH
1142 N 0 QIj a bond Me a bond NH 0 NH T3b OH
1143 N 0 QIj a bond Me a bond NH 0 NH T3c OH
1144 N 0 QIj a bond Me a bond NH 0 NH T3d OH 1145 N 0 QIj a bond Me a bond NH 0 NH T3e OH
1146 N 0 QIj a bond Me a bond NH 0 NH T3f OH
1147 N 0 QIj a bond Me a bond NH 0 NH T3g OH
1148 N 0 QIj a bond Me a bond NH 0 NH T3h OH
1149 N 0 QIj a bond Me a bond NH 0 NH T3i OH 1150 N 0 QIj a bond Me a bond NH 0 NH T3j OH
1151 N 0 QIj a bond Me a bond NH 0 a bond T3a OH
1152 N 0 QIj a bond Me a bond NH 0 a bond T3b OH
1153 N 0 QIj a bond Me a bond NH 0 a bond T3c OH
1154 N 0 QIj a bond Me a bond NH 0 a bond T3d OH 1155 N 0 QIj a bond Me a bond NH 0 a bond T3e OH
1156 N 0 QIj a bond Me a bond NH 0 a bond T3f OH
1157 N 0 QIj a bond Me a bond NH 0 a bond T3g OH
1158 N 0 QIj a bond Me a bond NH 0 a bond T3h OH
1159 N 0 QIj a bond Me a bond NH 0 a bond T3i OH 1160 N 0 QIj a bond Me a bond NH 0 a bond T3j OH
1161 N 0 QIj a bond H a bond NH S NH T3a OH
1162 N 0 QIj a bond H a bond NH S NH T3b OH
1163 N 0 QIj a bond H a bond NH S NH T3c OH
1164 N 0 QIj a bond H a bond NH S NH T3d OH 1165 N 0 QIj a bond H a bond NH S NH T3e OH
1166 N 0 QIj a bond H a bond NH S NH T3f OH 1167 N 0 QIj a bond H a bond NH S NH T3g OH
1168 N 0 QIj a bond H a bond NH S NH T3h OH
1169 N 0 QIj a bond H a bond NH S NH T3i OH
1170 N 0 QIj a bond H a bond NH S NH T3j OH 1171 N 0 QIj a bond H a bond I S a bond T3a OH
1172 N 0 QIj a bond H a bond NH S a bond T3b OH
1173 N 0 QIj a bond H a bond NH S a bond T3c OH
1174 N 0 QIj a bond H a bond NH S a bond T3d OH
1175 N 0 QIj a bond H a bond NH S a bond T3e OH 1176 N 0 QIj a bond H a bond NH S a bond T3f OH
1177 N 0 QIj a bond H a bond NH S a bond T3g OH
1178 N 0 QIj a bond H a bond NH S a bond T3h OH
1179 N 0 QIj a bond H a bond NH S a bond T3i OH
1180 N 0 QIj a bond H a bond NH S a bond T3j OH 1181 N 0 QIj a bond H a bond NH 0 NH T3a OH
1182 N 0 QIj a bond H a bond NH 0 NH T3b OH
1183 N 0 QIj a bond H a bond NH 0 NH T3c OH
1184 N 0 QIj a bond H a bond NH 0 NH T3d OH
1185 N 0 QIj a bond H a bond NH 0 NH T3e OH 1186 N 0 QIj a bond H a bond NH 0 NH T3f OH
1187 N 0 QIj a bond H a bond NH 0 NH T3g OH
1188 N 0 QIj a bond H a bond NH 0 NH T3h OH
1189 N 0 QIj a bond H a bond NH 0 NH T3i OH
1190 N 0 QIj a bond H a bond NH 0 NH T3j OH 1191 N 0 QIj a bond H a bond NH 0 a bond T3a OH
1192 N 0 QIj a bond H a bond NH 0 a bond T3b OH
1193 N 0 QIj a bond H a bond NH 0 a bond T3c OH
1194 N 0 QIj a bond H a bond NH 0 a bond T3d OH
1195 N 0 QIj a bond H a bond NH 0 a bond T3e OH 1196 N 0 QIj a bond H a bond NH 0 a bond T3f OH
1197 N 0 QIj a bond H a bond NH 0 a bond T3g OH
1198 N 0 QIj a bond H a bond NH 0 a bond T3h OH
1199 N 0 QIj a bond H a bond NH 0 a bond T3i OH
1200 N 0 QIj a bond H a bond NH 0 a bond T3j OH 1201 CH NMe QIa a bond Me a bond NH S NH T3a OH
1202 CH NMe QIa a bond Me a bond NH S NH T3b OH 1203 CH NMe QIa a bond Me a bond NH S NH T3c OH
1204 CH NMe QIa a bond Me a bond NH S NH T3d OH
1205 CH NMe QIa a bond Me a bond NH S NH T3e OH
1206 CH NMe QIa a bond Me a bond NH S NH T3f OH 1207 CH NMe QIa a bond Me a bond NH S NH T3g OH
1208 CH NMe QIa a bond Me a bond NH S NH T3h OH
1209 CH NMe QIa a bond Me a bond NH S NH T3i OH
1210 CH NMe QIa a bond Me a bond NH S NH T3j OH
1211 CH NMe QIa a bond Me a bond NH S a bond T3a OH 1212 CH NMe QIa a bond Me a bond NH S a bond T3b OH
1213 CH NMe QIa a bond Me a bond NH S a bond T3c OH
1214 CH NMe QIa a bond Me a bond NH S a bond T3d OH
1215 CH NMe QIa a bond Me a bond NH S a bond T3e OH
1216 CH NMe QIa a bond Me a bond NH S a bond T3f OH 1217 CH NMe QIa a bond Me a bond NH S a bond T3g OH
1218 CH NMe QIa a bond Me a bond NH S a bond T3h OH
1219 CH NMe QIa a bond Me a bond NH S a bond T3i OH
1220 CH NMe QIa a bond Me a bond NH S a bond T3j OH
1221 CH NMe QIa a' bond Me a bond NH 0 NH T3a OH 1222 CH NMe QIa a bond Me a bond NH 0 NH T3b OH
1223 CH NMe QIa a bond Me a bond NH 0 NH T3c OH
1224 CH NMe QIa a bond Me a bond NH 0 NH T3d OH
1225 CH NMe QIa a bond Me a bond NH 0 NH T3e OH
1226 CH NMe QIa a bond Me a bond NH 0 NH T3f OH 1227 CH NMe QIa a bond Me a bond NH 0 NH T3g OH
1228 CH NMe QIa a bond Me a bond NH 0 NH T3h OH
1229 CH NMe QIa a bond Me a bond NH 0 NH T3i OH
1230 CH NMe QIa a bond Me. a bond NH 0 NH T3j OH
1231 CH NMe QIa a bond Me a bond NH 0 a bond T3a OH 1232 CH NMe QIa a bond Me a bond NH 0 a bond T3b OH
1233 CH NMe QIa a bond Me a bond NH 0 a bond T3c OH
1234 CH NMe QIa a bond Me a bond NH 0 a bond T3d OH
1235 CH NMe QIa a bond Me a bond NH 0 a bond T3e OH
1236 CH NMe QIa a bond Me a bond NH 0 a bond T3f OH 1237 CH NMe QIa a bond Me a bond NH 0 a bond T3g OH
1238 CH NMe QIa a bond Me a bond NH 0 a bond T3h OH 1239 CH NMe QIa a bond Me a bond NH 0 a bond T3i OH
1240 CH NMe QIa a bond Me a bond NH 0 a bond T3j OH
1241 CH NMe QIa a bond H a bond NH S NH T3a OH
1242 CH NMe QIa a bond H a bond NH S NH T3b OH 1243 CH NMe QIa a bond H a bond 'NH S NH T3c OH
1244 CH NMe QIa a bond H a bond NH S NH T3d OH
1245 CH NMe QIa a bond H a bond NH S NH T3e OH
1246 CH NMe QIa a bond H a bond NH S NH T3f OH
1247 CH NMe QIa a bond H a bond NH S NH T3g OH 1248 CH NMe QIa a bond H a bond NH S NH T3h OH
1249 CH NMe QIa a bond H a bond NH S NH T3i OH
1250 CH NMe QIa a bond H a bond NH S NH T3j OH
1251 CH NMe QIa a bond H a bond NH S a bond T3a OH
1252 CH NMe QIa a bond H a bond NH S a bond T3b OH 1253 CH NMe QIa a bond H a bond NH S a bond T3c OH
1254 CH NMe QIa a bond H a bond NH S a bond T3d OH
1255 CH NMe QIa a bond H a bond NH S a bond T3e OH
1256 CH NMe QIa a bond H a bond NH S a bond T3f OH
1257 CH NMe QIa a bond H a bond NH S a bond T3g OH 1258 CH NMe QIa a bond H a bond NH S a bond T3h OH
1259 CH NMe QIa a bond H a bond NH S a bond T3i OH
1260 CH NMe QIa a bond H a bond NH S a bond T3j OH
1261 CH NMe QIa a bond H a bond NH 0 NH T3a OH
1262 CH NMe QIa a bond H a bond NH 0 NH T3b OH 1263 CH NMe QIa a bond H a bond NH 0 NH T3c OH
1264 CH NMe QIa a bond H a bond NH 0 NH T3d OH
1265 CH NMe QIa a bond H a bond NH 0 NH T3e OH
1266 CH NMe QIa a bond H a bond NH 0 NH T3f OH
1267 CH NMe QIa a bond H a bond NH 0 NH T3g OH 1268 CH NMe QIa a bond H a bond NH 0 NH T3h OH
1269 CH NMe QIa a bond H a bond NH 0 NH T3i OH
1270 CH NMe QIa a bond H a bond NH 0 NH T3j OH
1271 CH NMe QIa a bond H a bond NH 0 a bond T3a OH
1272 CH NMe QIa a bond H a bond NH 0 a bond T3b OH 1273 CH NMe QIa a bond H a bond NH 0 a bond T3c OH
1274 CH NMe QIa a bond H a bond NH 0 a bond T3d OH 1275 CH NMe QIa a bond H a bond NH 0 a bond T3e OH
1276 CH NMe QIa a bond H a bond NH 0 a bond T3f OH
1277 CH NMe QIa a bond H a bond NH 0 a bond T3g OH
1278 CH NMe QIa a bond H a bond NH 0 a bond T3h OH 1279 CH NMe QIa a bond H a bond I 0 a bond T3i OH
1280 CH NMe QIa a bond H a bond NH 0 a bond T3j OH
1281 CH NMe QIb a bond Me a bond NH S NH T3a OH
1282 CH NMe QIb a bond Me a bond NH S NH T3b OH
1283 CH NMe QIb a bond Me a bond NH S NH T3c OH 1284 CH NMe QIb a bond Me a bond NH S NH T3d OH
1285 CH NMe QIb a bond Me a bond NH S NH T3e OH
1286 CH NMe QIb a bond Me a bond NH S NH T3f OH
1287 CH NMe QIb a bond Me a bond NH S NH T3g OH
1288 CH NMe QIb a bond Me a bond NH S NH T3h OH 1289 CH NMe QIb a bond Me a bond NH S NH T3i OH
1290 CH NMe QIb a bond Me a bond NH S NH T3j OH
1291 CH NMe QIb a bond Me a bond NH S a bond T3a OH
1292 CH NMe QIb a bond Me a bond NH S a bond T3b OH
1293 CH NMe QIb a bond Me a bond NH S a bond T3c OH 1294 CH NMe QIb a bond Me a bond NH S a bond T3d OH
1295 CH NMe QIb a bond Me a bond NH S a bond T3e OH
1296 CH NMe QIb a bond Me a bond NH S a bond T3f OH
1297 CH NMe .QIb a bond Me a bond NH S a bond T3g OH
1298 CH NMe QIb a bond Me a bond NH S a bond T3h OH 1299 CH NMe QIb a bond Me a bond NH S a bond T3i OH
1300 CH NMe QIb a bond Me a bond NH S a bond T3j OH
1301 CH NMe QIb a bond Me a bond NH 0 NH T3a OH
1302 CH NMe QIb a bond Me a bond NH 0 NH T3b OH
1303 CH NMe QIb a bond Me a bond NH 0 NH T3c OH 1304 CH NMe QIb a bond Me a bond NH 0 NH T3d OH
1305 CH NMe QIb a bond Me a bond NH 0 NH T3e OH
1306 CH NMe QIb a bond Me a bond NH 0 NH T3f OH
1307 CH NMe QIb a bond Me a bond NH 0 NH T3g OH
1308 CH NMe QIb a bond Me a bond NH 0 NH T3h OH 1309 CH NMe QIb a bond Me a bond NH 0 NH T3i OH
1310 CH NMe QIb a bond Me a bond NH 0 NH T3j OH 1311 CH NMe QIb a bond Me a bond NH 0 a bond T3a OH
1312 CH NMe QIb a bond Me a bond NH 0 a bond T3b OH
1313 CH NMe QIb a bond Me a bond NH 0 a bond T3c OH
1314 CH NMe QIb a bond Me a bond NH 0 a bond T3d OH 1315 CH NMe QIb a bond Me a bond NH 0 a bond T3e OH
1316 CH NMe QIb a bond Me a bond NH 0 a bond T3f OH
1317 CH NMe QIb a bond Me a bond NH 0 a bond T3g OH
1318 CH NMe QIb a bond Me a bond NH 0 a bond T3h OH
1319 CH NMe QIb a bond Me a bond NH 0 a bond T3i OH 1320 CH NMe QIb a bond Me a bond NH 0 a bond T3j OH
1321 CH NMe QIb a bond H a bond NH S NH T3a OH
1322 CH NMe QIb a bond H a bond NH S NH T3b OH
1323 CH NMe QIb a bond H a bond NH S NH T3c OH
1324 CH NMe QIb a bond H a bond NH S NH T3d OH 1325 CH NMe QIb a bond H a bond NH S NH T3e OH
1326 CH NMe QIb a bond H a bond NH S NH T3f OH
1327 CH NMe QIb a bond H a bond NH S NH T3g OH
1328 CH NMe QIb a bond H a bond NH S NH T3h OH
1329 CH NMe QIb a bond H a bond NH S NH T3i OH 1330 CH NMe QIb a bond H a bond NH S NH T3j OH
1331 CH NMe QIb a bond H a bond NH S a bond T3a OH
1332 CH NMe QIb a bond H a bond NH S a bond T3b OH
1333 CH NMe QIb a bond H a bond NH S a bond T3c OH
1334 CH NMe QIb a bond H a bond NH S a bond T3d OH 1335 CH NMe QIb a bond H a bond NH S a bond T3e OH
1336 CH NMe QIb a bond H a bond NH S a bond T3f OH
1337 CH NMe QIb a bond H a bond NH S a bond T3g OH
1338 CH NMe QIb a bond H a bond NH S a bond T3h OH
1339 CH NMe QIb a bond H a bond NH S a bond T3i OH 1340 CH NMe QIb a bond H a bond NH S a bond T3j OH
1341 CH NMe QIb a bond H a bond NH 0 NH T3a OH
1342 CH NMe QIb a bond H a bond NH 0 NH T3b OH
1343 CH NMe QIb a bond H a bond NH 0 NH T3c OH
1344 CH NMe QIb a bond H a bond NH 0 NH T3d OH 1345 CH NMe QIb a bond H a bond NH 0 NH T3e OH
1346 CH NMe QIb a bond H a bond NH 0 NH T3f OH 1347 CH NMe QIb a bond H a bond NH O NH T3g OH
1348 CH NMe QIb a bond H a bond NH 0 NH T3h OH
1349 CH NMe QIb a bond H a bond NH 0 NH T3i OH
1350 CH NMe QIb a bond H a bond NH 0 NH T3j OH 1351 CH NMe QIb a bond H a bond 'NH 0 a bond T3a OH
1352 CH NMe QIb a bond H a bond NH 0 a bond T3b OH
1353 CH NMe QIb a bond H a bond NH 0 a bond T3c OH
1354 CH NMe QIb a bond H a bond NH 0 a bond T3d OH
1355 CH NMe QIb a bond H a bond NH 0 a bond T3e OH 1356 CH NMe QIb a bond H a bond NH 0 a bond T3f OH
1357 CH NMe QIb a bond H a bond NH 0 a bond T3g OH
1358 CH NMe QIb a bond H a bond NH 0 a bond T3h OH
1359 CH NMe QIb a bond H a bond NH 0 a bond T3i OH
1360 CH NMe QIb a bond H a bond NH 0 a bond T3j OH 1361 CH NMe QIc a bond Me a bond NH S NH T3a OH
1362 CH NMe QIc a bond Me a bond NH S NH T3b OH
1363 CH NMe QIc a bond Me a bond NH S NH T3c OH
1364 CH NMe QIc a bond Me a bond NH S NH T3d OH
1365 CH NMe QIc a bond Me a bond NH S NH T3e OH 1366 CH NMe QIc a bond Me a bond NH S NH T3f OH
1367 CH NMe QIc a bond Me a bond NH S NH T3g OH
1368 CH NMe QIc a bond Me a bond NH S NH T3h OH
1369 CH NMe QIc a bond Me a bond NH S NH T3i OH
1370 CH NMe QIc a bond Me a bond NH S NH T3j OH 1371 CH NMe QIc a bond Me a bond NH S a bond T3a OH
1372 CH NMe QIc a bond Me a bond NH S a bond T3b OH
1373 CH NMe QIc a bond Me a bond NH S a bond T3c OH
1374 CH NMe QIc a bond Me a bond NH S a bond T3d OH
1375 CH NMe QIc a bond Me a bond NH S a bond T3e OH 1376 CH NMe QIc a bond Me a bond NH S a bond T3f OH
1377 CH NMe QIc a bond Me a bond NH S a bond T3g OH
1378 CH NMe QIc a bond Me a bond NH S a bond T3h OH
1379 CH NMe QIc a bond Me a bond NH S a bond T3i OH
1380 CH NMe QIc a bond Me a bond NH S a bond T3j OH 1381 CH NMe QIc a bond Me a bond NH 0 NH T3a OH
1382 CH NMe QIc a bond Me a bond NH 0 NH T3b OH 1383 CH NMe QIc a bond Me a bond NH 0 NH T3c OH
1384 CH NMe QIc a bond Me a bond NH 0 NH T3d OH
1385 CH NMe QIc a bond Me a bond NH 0 NH T3e OH
1386 CH NMe QIc a bond Me a bond NH 0 NH T3f OH 1387 CH NMe QIc a bond Me a bond' NH 0 NH T3g OH
1388 CH NMe QIc a bond Me a bond NH 0 NH T3h OH
1389 CH NMe QIc a bond Me a bond NH 0 NH T3i OH
1390 CH NMe QIc a bond Me a bond NH 0 NH T3j OH
1391 CH NMe QIc a bond Me a bond NH 0 a bond T3a OH 1392 CH NMe QIc a bond Me a bond NH 0 a bond T3b OH
1393 CH NMe QIc a bond Me a bond NH 0 a bond T3c OH
1394 CH NMe QIc a bond Me a bond NH 0 a bond T3d OH
1395 CH NMe QIc a bond Me a bond NH 0 a bond T3e OH
1396 CH NMe QIc a bond Me a bond NH 0 a bond T3f OH 1397 CH NMe QIc a bond Me a bond NH 0 a bond T3g OH
1398 CH NMe QIc a bond Me a bond NH 0 a bond T3h OH
1399 CH NMe QIc a bond Me a bond NH 0 a bond T3i OH
1400 CH NMe QIc a bond Me a bond NH 0 a bond T3j OH
1401 CH NMe QIc a bond H a bond NH S NH T3a OH 1402 CH NMe QIc a bond H a bond NH S NH T3b OH
1403 CH NMe QIc a bond H a bond NH S NH T3c OH
1404 CH NMe QIc a bond H a bond NH S NH T3d OH
1405 CH NMe QIc a bond H a bond NH S NH T3e OH
1406 CH NMe QIc a bond H a bond NH S NH T3f OH 1407 CH NMe QIc a bond H a bond NH S NH T3g OH
1408 CH NMe QIc a bond H a bond NH S NH T3h OH
1409 CH NMe QIc a bond H a bond NH S NH T3i OH
1410 CH NMe QIc a bond H a bond NH S NH T3j OH
1411 CH NMe QIc a bond H a bond NH S a bond T3a OH 1 1441122 C CHH N NMMee QIc a bond H a bond NH S a bond T3b OH
1413 CH NMe QIc a bond H a bond NH S a bond T3c OH
1414 CH NMe QIc a bond H a bond NH S a bond T3d OH
1415 CH NMe QIc a bond H a bond NH S a bond T3e OH
1416 CH NMe QIc a bond H a bond NH S a bond T3f OH 1417 CH NMe QIc a bond H a bond NH S a bond T3g OH
1418 CH NMe QIc a bond H a bond NH S a bond T3h OH 1419 CH NMe QIc a bond H a bond NH S a bond T3i OH
1420 CH NMe QIc a bond H a bond NH S a bond T3j OH
1421 CH NMe QIc a bond H a bond NH 0 NH T3a OH
1422 CH NMe QIc a bond H a bond NH 0 NH T3b OH 1423 CH NMe QIc a bond H a bond 'NH 0 NH T3C OH
1424 CH NMe QIc a bond H a bond NH 0 NH T3d OH
1425 CH NMe QIc a bond H a bond NH 0 NH T3e OH
1426 CH NMe QIc a bond H a bond NH 0 NH T3f OH
1427 CH NMe QIc a bond H a bond NH 0 NH T3g OH 1428 CH NMe QIc a bond H a bond NH 0 NH T3h OH
1429 CH NMe QIc a bond H a bond NH 0 NH T3i OH
1430 CH NMe QIc a bond H a bond NH 0 NH T3j OH
1431 CH NMe QIc a bond H a bond NH 0 a bond T3a OH
1432 CH NMe QIc a bond H a bond NH 0 a bond T3b OH 1433 CH NMe QIc a bond H a bond NH 0 a bond T3c OH
1434 CH NMe QIc a bond H a bond NH 0 a bond T3d OH
1435 CH NMe QIc a bond H a bond NH 0 a bond T3e OH
1436 CH NMe QIc a bond H a bond NH 0 a bond T3f OH
1437 CH NMe QIc a bond H a bond NH 0 a bond T3g OH 1438 CH NMe QIc a bond H a bond NH 0 a bond T3h OH
1439 CH NMe QIc a bond H a bond NH 0 a bond T3i OH
1440 CH NMe QIc a bond H a bond NH 0 a bond T3j OH
1441 CH NMe QIi a bond Me a bond NH NH T3a OH
1442 CH NMe QIi a bond Me a bond NH NH T3b OH 1443 CH NMe QIi a bond Me a bond NH S NH T3c OH
1444 CH NMe QIi a bond Me a bond NH S NH T3d OH
1445 CH NMe QIi a bond Me a bond NH S NH T3e OH
1446 CH NMe QIi a bond Me a bond NH S NH T3f OH
1447 CH NMe QIi a bond Me a bond NH S NH T3g OH
1448 CH NMe QIi a bond Me a bond NH S NH T3h OH
1449 CH NMe QIi a bond Me a bond NH S NH T3i OH
1450 CH NMe QIi a bond Me a bond NH S NH T3j OH
1451 CH NMe QIi a bond Me a bond NH S a bond T3a OH
1452 CH NMe QIi a bond Me a bond NH S a bond T3b OH
1453 CH NMe QIi a bond Me a bond NH S a bond T3c OH
1454 CH NMe QIi a bond Me a bond NH S a bond T3d OH 1455 CH NMe QIi a bond Me a bond NH S a bond T3e OH
1456 CH NMe QIi a bond Me a bond NH S a bond T3f OH
1457 CH NMe QIi a bond Me a bond NH S a bond T3g OH
1458 CH NMe QIi a bond Me a bond NH S a bond T3h OH 1459 CH NMe QIi a bond Me a bond NH S a bond T3i OH
1460 CH NMe QIi a bond Me a bond NH S a bond T3j OH
1461 CH NMe QIi a bond Me a bond NH 0 NH T3a OH
1462 CH NMe QIi a bond Me a bond NH 0 NH T3b OH
1463 CH NMe QIi a bond Me a bond NH 0 NH T3c OH 1464 CH NMe QIi a bond Me a bond NH 0 NH T3d OH
1465 CH NMe QIi a bond Me a bond NH 0 NH T3e OH
1466 CH NMe QIi a bond Me a bond NH 0 NH T3f OH
1467 CH NMe QIi a bond Me a bond NH 0 NH T3g OH
1468 CH NMe QIi a bond Me a bond NH 0 NH T3h OH 1469 CH NMe QIi a bond Me a bond NH 0 NH T3i OH
1470 CH NMe QIi a bond Me a bond NH 0 NH T3j OH
1471 CH NMe QIi a bond Me a bond NH 0 a bond T3a OH
1472 CH NMe QIi a bond Me a bond NH 0 a bond T3b OH
1473 CH NMe QIi a bond Me a bond NH 0 a bond T3c OH 1474 CH NMe QIi a bond Me a bond NH 0 a bond T3d OH
1475 CH NMe QIi a bond Me a bond NH 0 a bond T3e OH
1476 CH NMe QIi a bond Me a bond NH 0 a bond T3f OH
1477 CH NMe QIi a bond Me a bond NH 0 a bond T3g OH
1478 CH NMe QIi a bond Me a bond NH 0 a bond T3h OH 1479 CH NMe QIi a bond Me a bond NH 0 a bond T3i OH
1480 CH NMe QIi a bond Me a bond NH 0 a bond T3j OH
1481 CH NMe QIi a bond H a bond NH S NH T3a OH
1482 CH NMe QIi a bond H a bond NH S NH T3b OH
1483 CH NMe QIi a bond H a bond NH S NH T3c OH 1484 CH NMe QIi a bond H a bond NH S NH T3d OH
1485 CH NMe QIi a bond H a bond NH S NH T3e OH
1486 CH NMe QIi a bond H a bond NH S NH T3f OH
1487 CH NMe QIi a bond H a bond NH S NH T3g OH
1488 CH NMe QIi a bond H a bond NH S NH T3h OH 1489 CH NMe QIi a bond H a bond NH S NH T3i OH
1490 CH NMe QIi a bond H a bond NH S NH T3j OH 1491 CH NMe QIi a bond H a bond NH S a bond T3a OH
1492 CH NMe QIi a bond H a bond NH S a bond T3b OH
1493 CH NMe QIi a bond H a bond NH S a bond T3c OH
1494 CH NMe QIi a bond H a bond NH S a bond T3d OH 1495 CH NMe QIi a bond H a bond 'NH S a bond T3e OH
1496 CH NMe QIi a bond H a bond NH S a bond T3f OH
1497 CH NMe QIi a bond H a bond NH S a bond T3g OH
1498 CH NMe QIi a bond H a bond NH S a bond T3h OH
1499 CH NMe QIi a bond H a bond NH S a bond T3i OH 1500 CH NMe QIi a bond H a bond NH S a bond T3j OH
1501 CH NMe QIi a bond H a bond NH 0 NH T3a OH
1502 CH NMe QIi a bond H a bond NH 0 NH T3b OH
1503 CH NMe QIi a bond H a bond NH 0 NH T3c OH
1504 CH NMe QIi a bond H a bond NH 0 NH T3d OH 1505 CH NMe QIi a bond H a bond NH 0 NH T3e OH
1506 CH NMe QIi a bond H a bond NH 0 NH T3f OH
1507 CH NMe QIi a bond H a bond NH 0 NH T3g OH
1508 CH NMe QIi a bond H a bond NH 0 NH T3h OH
1509 CH NMe QIi a bond H a bond NH 0 NH T3i OH 1510 CH NMe QIi a bond H a bond NH 0 NH T3j OH
1511 CH NMe QIi a bond H a bond NH 0 a bond T3a OH
1512 CH NMe QIi a bond H a bond NH 0 a bond T3b OH
1513 CH NMe QIi a bond H a bond NH 0 a bond T3c OH
1514 CH NMe QIi a bond H a bond NH 0 a bond T3d OH 1515 CH NMe QIi a bond H a bond NH 0 a bond T3e OH
1516 CH NMe QIi a bond H a bond NH 0 a bond T3f OH
1517 CH NMe QIi a bond H a bond NH 0 a bond T3g OH
1518 CH NMp QIi a bond H a bond NH 0 a bond T3h OH
1519 CH NMe QIi a bond H a bond NH 0 a bond T3i OH 1520 CH NMe QIi a bond H a bond NH 0 a bond T3j OH
1521 CH NMe QIj a bond Me a bond NH S NH T3a OH
1522 CH NMe QIj a bond Me a bond NH S NH T3b OH
1523 CH NMe QIj a bond Me a bond NH S NH T3c OH
1524 CH NMe QIj a bond Me a bond NH S NH T3d OH 1525 CH NMe QIj a bond Me a bond NH S NH T3e OH
1526 CH NMe QIj a bond Me a bond NH S NH T3f OH 1527 CH NMe QIj a bond Me a bond NH S NH T3g OH
1528 CH NMe QIj a bond Me a bond NH S NH T3h OH
1529 CH NMe QIj a bond Me a bond NH S NH T3i OH
1530 CH NMe QIj a bond Me a bond NH S NH T3j OH
1531 CH NMe QIj a bond Me a bond NH S a bond T3a OH
1532 CH NMe QIj a bond Me a bond NH S a bond T3b OH
1533 CH NMe QIj a bond Me a bond NH S a bond T3c OH
1534 CH NMe QIj a bond Me a bond NH S a bond T3d OH
1535 CH NMe QIj a bond Me a bond NH S a bond T3e OH
1536 CH NMe Qij a bond Me a bond NH S a bond T3f OH
1537 CH NMe QIj a bond Me a bond NH S a bond T3g OH
1538 CH NMe Qij a bond Me a bboonndd N NHH S S aa bboonndd T T33hh O OHH
1539 CH NMe QIj a bond Me a bboonndd N NHH S S aa bboonndd T T33ii O OHH
1540 CH NMe QIj a bond Me a bboonndd N NHH S S aa bboonndd T T33jj O OHH
1541 CH NMe QIj a bond Me a bboonndd N NHH 0 0 H H T T33aa O OHH
1542 CH NMe QIj a bond Me a bboonndd N NHH 0 0 N NHH T T33bb O OHH
1543 CH NMe QIj a bond Me a bond NH 0 NH T3c OH
1544 CH NMe QIj a bond Me a bond NH 0 NH T3d OH
1545 CH NMe QIj a bond Me a bond NH 0 NH T3e OH
1546 CH NMe Qij a bond Me a bond NH 0 NH T3f OH
1547 CH NMe QIj a bond Me a bond NH 0 NH T3g OH
1548 CH NMe Qij a bond Me a bond NH 0 NH T3h OH
1549 CH NMe Qij a bond Me a bond NH 0 NH T3i OH
1550 CH NMe Qij a bond Me a bond NH 0 NH T3j OH
1551 CH NMe Qij a bond Me a bond NH 0 a bond T3a OH
1552 CH NMe QIj a bond Me a bond NH 0 a bond T3b OH
1553 CH NMe QIj a bond Me a bond NH 0 a bond T3c OH
1554 CH NMe QIj a bond Me a bond NH 0 a bond T3d OH
1555 CH NMe QIj a bond Me a bond NH 0 a bond T3e OH
1556 CH NMe QIj a bond Me a bond NH 0 a bond T3f OH
1557 CH NMe QIj a bond Me a bond NH 0 a bond T3g OH
1558 CH NMe QIj a bond Me a bond NH 0 a bond T3h OH
1559 CH NMe QIj a bond Me a bond NH 0 a bond T3i OH
1560 CH NMe Qij a bond Me a bond NH 0 a bond T3j OH
1561 CH NMe Qij a bond H a bond NH S NH T3a OH
1562 CH NMe Qij a bond H a bond NH S NH T3b OH 1563 CH NMe Qij a bond H a bond NH S NH T3c OH
1564 CH NMe Qij a bond H a bond NH S NH T3d OH
1565 CH NMe Qij a bond H a bond NH S NH T3e OH
1566 CH NMe Qij a bond H a bond NH S NH T3f OH
1567 CH NMe Qij a bond H a bond ' NH S NH T3g OH
1568 CH NMe Qij a bond H a bond NH S NH T3h OH
1569 CH NMe Qij a bond H a bond NH S NH T3i OH
1570 CH NMe Qij a bond H a bond NH S NH T3j OH
1571 CH NMe Qij a bond H a bond NH S a bond T3a OH
1572 CH NMe Qij a bond H a bond NH S a bond T3b OH
1573 CH NMe Qij a bond H a bond NH S a bond T3c OH
1574 CH NMe Qij a bond H a bond NH S a bond T3d OH
1575 CH NMe Qij a bond H a bond NH S a bond T3e OH
1576 CH NMe QIj a bond H a bond NH S a bond T3f OH
1577 CH NMe QIj a bond H a bond NH S a bond T3g OH
1578 CH NMe Qij a bond H a bond NH S a bond T3h OH
1579 CH NMe Qij a bond H a bond NH S a bond T3i OH
1580 CH NMe Qij a bond H a bond NH S a bond T3j OH
1581 CH NMe Qij a bond H a bond NH 0 NH T3a OH
1582 CH NMe QIi a bond H a bond NH 0 NH T3b OH
1583 CH NMe QIj a bond H a bond NH 0 NH T3c OH
1584 CH NMe QIj a bond H a bond NH 0 NH T3d OH
1585 CH NMe QIj a bond H a bond NH 0 NH T3e OH
1586 CH NMe QIj a bond H a bond NH 0 NH T3f OH
1587 CH NMe QIj a bond H a bond NH 0 NH T3g OH
1588 CH NMe QIj a bond H a bond NH 0 NH T3h OH
1589 CH NMe QIj a bond H a bond NH 0 NH T3i OH
1590 CH NMe QIj a bond H aa bond NH 0 NH T3j OH
1591 CH NMe QIj a bond H a bond NH 0 a bond T3a OH
1592 CH NMe QIj a bond H a bond NH 0 a bond T3b OH
1593 CH NMe QIj a bond H aa bboonndd NH 0 a bond T3c OH
1594 CH NMe QIj a bond H a bond NH 0 a bond T3d OH
1595 CH NMe QIj a bond H a bond NH 0 a bond T3e OH
1596 CH NMe QIj a bond H a bond NH 0 a bond T3f OH
1597 CH NMe QIj a bond H a bond NH 0 a bond T3g OH
1598 CH NMe QIj a bond H a bond NH 0 a bond T3h OH 1599 CH NMe QIj a bond H a bond NH 0 a bond T3i OH
1600 CH NMe QIj a bond H a bond NH 0 a bond T3j OH
1601 CH S QIa a bond Me a bond NH S NH T3a OH
1602 CH S QIa a bond Me a bond NH S NH T3b OH 1603 CH S QIa a bond Me a bond 1 S i T3c OH
1604 CH S QIa a bond Me a bond NH S NH T3d OH
1605 CH S QIa a bond Me a bond NH S NH T3e OH
1606 CH S QIa a bond Me a bond NH S NH T3f OH
1607 CH S QIa a bond Me a bond NH S NH T3g OH 1608 CH S QIa a bond Me a bond NH S NH T3h OH
1609 CH S QIa a bond Me a bond NH S NH T3i OH
1610 CH S QIa a bond Me a bond NH S NH T3j OH
1611 CH S QIa a bond Me a bond NH S a bond T3a OH
1612 CH S QIa a bond Me a bond NH S a bond T3b OH 1613 CH S QIa a bond Me a bond NH S a bond T3c OH
1614 CH S QIa a bond Me a bond NH S a bond T3d OH
1615 CH S QIa a bond Me a bond NH S a bond T3e OH
1616 CH S QIa a bond Me a bond NH S a bond T3f OH
1617 CH S QIa a bond Me a bond NH S a bond T3g OH 1618 CH S QIa a bond Me a bond NH S a bond T3h OH
1619 CH S QIa a bond Me a bond NH S a bond T3i OH
1620 CH S QIa a bond Me a bond NH S a bond T3j OH
1621 CH S QIa a bond Me a bond NH 0 NH T3a OH
1622 CH S QIa a bond Me a bond NH 0 NH T3b OH 1623 CH S QIa a bond Me a bond NH 0 NH T3c OH
1624 CH S QIa a bond Me a bond NH 0 NH T3d OH
1625 CH S QIa a bond Me a bond NH 0 NH T3e OH
1626 CH S QIa a bond Me a bond NH 0 NH T3f OH
1627 CH S QIa a bond Me a bond NH 0 NH T3g OH 1628 CH S QIa a bond Me a bond NH 0 NH T3h OH
1629 CH S QIa a bond Me a bond NH 0 NH T3i OH
1630 CH S QIa a bond Me a bond NH 0 NH T3j OH
1631 CH S QIa a bond Me a bond NH 0 a bond T3a OH
1632 CH S QIa a bond Me a bond NH 0 a bond T3b OH 1633 CH S QIa a bond Me a bond NH 0 a bond T3c OH
1634 ' CH S QIa a bond Me a bond NH 0 a bond T3d OH 1635 CH S QIa a bond Me a bond NH 0 a bond T3e OH
1636 CH S QIa a bond Me a bond NH 0 a bond T3f OH
1637 CH S QIa a bond Me a bond NH 0 a bond T3g OH
1638 CH S QIa a bond Me a bond NH 0 a bond T3h OH
1639 CH S QIa a bond Me a bond NH 0 a bond T3i OH
1640 CH S QIa a bond Me a bond NH 0 a bond T3j OH
1641 CH S QIa a bond H a bond NH S NH T3a OH
1642 CH S QIa a bond H a bond NH S NH T3b OH
1643 CH S QIa a bond H a bond NH S NH T3c OH
1644 CH S QIa a bond H a bond NH S NH T3d OH
1645 CH S QIa a bond H a bond NH S NH T3e OH
1646 CH S QIa a bond H a bond NH S NH T3f OH
1647 CH S QIa a bond H a bond NH S NH T3g OH
1648 CH S QIa a bond H a bond NH S NH T3h OH
1649 CH S QIa a bond H a bond NH S NH T3i OH
1650 CH S QIa a bond H a bond NH S NH T3j OH
1651 CH S QIa a bond H a bond NH S a bond T3a OH
1652 CH S QIa a bond H a bond NH S a bond T3b OH
1653 CH S QIa a bond H a bond NH S a bond T3c OH
1654 CH S QIa a bond H a bond NH S a bond T3d OH
1655 CH S QIa a bond H a bond NH S a bond T3e OH
1656 CH S QIa a bond H a bond NH S a bond T3f OH
1657 CH S QIa a bond H a bond NH S a bond T3g OH
1658 CH S QIa a bond H a bond NH S a bond T3h OH
1659 CH S QIa a bond H a bond NH S a bond T3i OH
1660 CH S QIa a bond H a bond NH S a bond T3j OH
1661 CH S QIa a bond H a bond NH 0 NH T3a OH
1662 CH S QIa a bond H a bond NH 0 NH T3b OH
1663 CH S QIa a bond H a bond NH 0 NH T3c OH
1664 CH S QIa a bond H a bond NH 0 NH T3d OH
1665 CH S QIa a bond H a bond NH 0 NH T3e OH
1666 CH S QIa a bond H a bond NH 0 NH T3f OH
1667 CH S QIa a bond H a bond NH 0 NH T3g OH
1668 CH S QIa a bond H a bond NH 0 NH T3h OH
1669 CH S QIa a bond H a bond NH 0 NH T3i OH
1670 CH S QIa a bond H a bond NH 0 NH T3i OH 1671 CH S QIa a bond H a bond NH 0 a bond T3a OH
1672 CH S QIa a bond H a bond NH 0 a bond T3b OH
1673 CH S QIa a bond H a bond NH 0 a bond T3c OH
1674 CH S QIa a bond H a bond NH 0 a bond T3d OH
1675 CH S QIa a bond H a bond NH 0 a bond T3e OH
1676 CH S QIa a bond H a bond NH 0 a bond T3f OH
1677 CH S QIa a bond H a bond NH 0 a bond T3g OH
1678 CH S QIa a bond H a bond NH 0 a bond T3h OH
1679 CH S QIa a bond H a bond NH 0 a bond T3i OH
1680 CH S QIa a bond H a bond NH 0 a bond T3j OH
1681 CH S QIb a bond Me a bond NH S NH T3a OH
1682 CH S QIb a bond Me a bond NH S NH T3b OH
1683 CH S QIb a bond Me a bond NH S NH T3c OH
1684 CH S QIb a bond Me a bond NH S NH T3d OH
1685 CH S QIb a bond Me a bond NH S NH T3e OH
1686 CH S QIb a bond Me a bond NH S NH T3f OH
1687 CH S QIb a bond Me a bond NH S NH T3g OH
1688 CH S QIb a bond Me a bond NH S NH T3h OH
1689 CH S QIb a bond Me a bond NH S NH T3i OH
1690 CH S QIb a bond Me a bond NH S NH T3j OH
1691 CH S QIb a bond Me a bond NH S a bond T3a OH
1692 CH S QIb a bond Me a bond NH S a bond T3b OH
1693 CH S QIb a bond Me a bond NH S a bond T3c OH
1694 CH S QIb a bond Me a bond NH S a bond T3d OH
1695 CH S QIb a bond Me a bond NH S a bond T3e OH
1696 CH S QIb a bond Me a bond NH S a bond T3f OH
1697 CH S QIb a bond Me a bond NH S a bond T3g OH
1698 CH S QIb a bond Me a bond NH S a bond T3h OH
1699 CH S QIb a bond Me a bond NH S a bond T3i OH
1700 CH S QIb a bond Me a bond NH S a bond T3j OH
1701 CH S QIb a bond Me a bond NH 0 NH T3a OH
1702 CH S QIb a bond Me a bond NH 0 NH T3b OH
1703 CH S QIb a bond Me a bond NH 0 NH T3c OH
1704 CH S QIb a bond Me a bond NH 0 NH T3d OH
1705 CH S QIb a bond Me a bond NH 0 NH T3e ' OH
1706 CH S QIb a bond Me a bond NH 0 NH T3f OH 1707 CH S QIb a bond Me a bond NH 0 NP1 T3g OH
1708 CH S QIb a bond Me a bond NH 0 If \ T3h OH
1709 CH S QIb a bond Me a bond NH 0 Nl { T3i OH
1710 CH S QIb a bond Me a bond NH 0 Mi T3j OH
1711 CH S QIb a bond Me a bond NH 0 a bond T3a OH
1712 CH S QIb a bond Me a bond NH 0 a bond T3b OH
1713 CH S QIb a bond Me a bond NH 0 a bond T3c OH
1714 CH S QIb a bond Me a bond NH 0 a bond T3d OH
1715 CH S QIb a bond Me a bond NH 0 a bond T3e OH
1716 CH S QIb a bond Me a bond NH 0 a bond T3f OH
1717 CH S QIb a bond Me a bond NH 0 a bond T3g OH
1718 CH S QIb a bond Me a bond NH 0 a bond T3h OH
1719 CH S QIb a bond Me a bond NH 0 a bond T3i OH
1720 CH S QIb a bond Me a bond NH 0 a bond T3j OH
1721 CH S QIb a bond H a bond NH S NH T3a OH
1722 CH S QIb a bond H a bond NH S NH T3b OH
1723 CH S QIb a bond H a bond NH S NH T3c OH
1724 CH S QIb a bond H a bond NH S NH T3d OH
1725 CH S QIb a bond H a bond NH S NH T3e OH
1726 CH S QIb a bond H a bond NH S NH T3f OH
1727 CH S QIb a bond H a bond NH S NH T3g OH
1728 CH S QIb a bond H a bond NH S NH T3h OH
1729 CH S QIb a bond H a bond NH S NH T3i OH
1730 CH S QIb a bond H a bond NH S NH T3j OH
1731 CH S QIb a bond H a bond NH S a bond T3a OH
1732 CH S QIb a bond H a bond NH S a bond T3b OH
1733 CH S QIb a bond H a bond NH S a bond T3c OH
1734 CH S QIb a bond H a bond NH S a bond T3d OH
1735 CH S QIb a bond H a bond NH S a bond T3e OH
1736 CH S QIb a bond H a bond NH S a bond T3f OH
1737 CH S QIb a bond H a bond NH S a bond T3g OH
1738 CH S QIb a bond H a bond NH S a bond T3h OH
1739 CH S QIb a bond H a bond NH S a bond T3i OH
1740 CH S QIb a bond H a bond NH S a bond T3j OH
1741 CH S QIb a bond H a bond NH 0 NH T3a OH
1742 CH S QIb a bond H a bond NH 0 NH T3b OH 1743 CH S QIb a bond H a bond NH 0 NH T3c OH
1744 CH S QIb a bond H a bond NH 0 NH T3d OH
1745 CH S QIb a bond H a bond NH 0 NH T3e OH
1746 CH S QIb a bond H a bond NH 0 NH T3f OH
1747 CH S QIb a bond H a bond NH 0 NH T3g OH
1748 CH S QIb a bond H a bond NH 0 NH T3h OH
1749 CH S QIb a bond H a bond NH 0 NH T3i OH
1750 CH S QIb a bond H a bond NH 0 NH T3j OH
1751 CH S QIb a bond H a bond NH 0 a bond T3a OH
1752 CH S QIb a bond H a bond NH 0 a bond T3b OH
1753 CH S QIb a bond H a bond NH 0 a bond T3c OH
1754 CH S QIb a bond H a bond NH 0 a bond T3d OH
1755 CH S QIb a bond H a bond NH 0 a bond T3e OH
1756 CH S QIb a bond H a bond NH 0 a bond T3f OH
1757 CH S QIb a bond H a bond NH 0 a bond T3g OH
1758 CH S QIb a bond H a bond NH 0 a bond T3h OH
1759 CH S QIb a bond H a bond NH 0 a bond T3i OH
1760 CH S QIb a bond H a bond NH 0 a bond T3j OH
1761 CH S QIc a bond Me a bond NH S NH T3a OH
1762 CH S QIc a bond Me a bond NH S NH T3b OH
1763 CH S QIc a bond Me a bond NH S NH T3c OH
1764 CH S QIc a bond Me a bond NH S NH T3d OH
1765 CH S QIc a bond Me a bond NH S NH T3e OH
1766 CH S QIc a bond Me a bond NH S NH T3f OH
1767 CH S QIc a bond Me a bond NH S NH T3g OH
1768 CH S QIc a bond Me a bond NH S NH T3h OH
1769 CH S QIc a bond Me a bond NH S NH T3i OH
1770 CH S QIc a bond Me a bond NH S NH T3j OH
1771 CH S QIc a bond Me a bond NH S a bond T3a OH
1772 CH S QIc a bond Me a bond NH S a bond T3b OH
1773 CH S QIc a bond Me a bond NH S a bond T3c OH
1774 CH S QIc a bond Me a bond NH S a bond T3d OH
1775 CH S QIc a bond Me a bond NH S a bond T3e OH
1776 CH S QIc a bond Me a bond NH S a bond T3f OH
1777 CH S QIc a bond Me a bond NH S a bond T3g OH
1778 CH S QIc a bond Me a bond NH S a bond T3h OH 1779 CH S QIc a bond Me a bond NH S a bond T3i OH
1780 CH S QIc a bond Me a bond NH S a bond T3j OH
1781 CH S QIc a bond Me a bond NH 0 NI 1 T3a OH
1782 CH S QIc a bond Me a bond NH 0 NH T3b OH
1783 CH S QIc a bond Me a bond 'NH 0 NH T3c OH
1784 CH S QIc a bond Me a bond NH 0 NI 1 T3d OH
1785 CH S QIc a bond Me a bond NH 0 NIi T3e OH
1786 CH S QIc a bond Me a bond NH 0 NH T3f OH
1787 CH S QIc a bond Me a bond NH 0 NI 4 T3g OH
1788 CH S QIc a bond Me a bond NH 0 NH T3h OH
1789 CH S QIc a bond Me a bond NH 0 NI 1 T3i OH
1790 CH S QIc a bond Me a bond NH 0 NIi T3j OH
1791 CH S QIc a bond Me a bond NH 0 a bond T3a OH
1792 CH S QIc a bond Me a bond NH 0 a bond T3b OH
1793 CH S QIc a bond Me a bond NH 0 a bond T3c OH
1794 CH S QIc a bond Me a bond NH 0 a bond T3d OH
1795 CH S QIc a bond Me a bond NH 0 a bond T3e OH
1796 CH S QIc a bond Me a bond NH 0 a bond T3f OH
1797 CH S QIc a bond Me a bond NH 0 a bond T3g OH
1798 CH S QIc a bond Me a bond NH 0 a bond T3h OH
1799 CH S QIc a bond Me a bond NH 0 a bond T3i OH
1800 CH S QIc a bond Me a bond NH 0 a bond T3j OH
1801 CH S QIc a bond H a bond NH S NH T3a OH
1802 CH S QIc a bond H a bond NH S NH T3b OH
1803 CH S QIc a bond H a bond NH S NH T3c OH
1804 CH S QIc a bond H a bond NH S NH T3d OH
1805 CH S QIc a bond H a bond NH S NH T3e OH
1806 CH S QIc a bond H a bond NH S NH T3f OH
1807 CH S QIc a bond H a bond NH S NH T3g OH
1808 CH S QIc a bond H a bond NH S NH T3h OH
1809 CH S QIc a bond H a bond NH S NH T3i OH
1810 CH S QIc a bond H a bond NH S NH T3j OH
1811 CH S QIc a bond H a bond NH S a bond T3a OH
1812 CH S QIc a bond H a bond NH S a bond T3b OH
1813 CH S QIc a bond H a bond NH S a bond T3c OH
1814 CH S QIc a bond H a bond NH S a bond T3d OH 1815 CH S QIc a bond H a bond NH S a bond T3e OH
1816 CH S QIc a bond H a bond NH S a bond T3f OH
1817 CH S QIc a bond H a bond NH S a bond T3g OH
1818 CH S QIc a bond H a bond NH S a bond T3h OH
1819 CH S QIc a bond H a bond NH S a bond T3i OH
1820 CH S QIc a bond H a bond NH S a bond T3j OH
1821 CH S QIc a bond H a bond NH 0 NH T3a OH
1822 CH S QIc a bond H a bond NH 0 NH T3b OH
1823 CH S QIc a bond H a bond NH 0 NH T3c OH
1824 CH S QIc a bond H a bond NH 0 NH T3d OH
1825 CH S QIc a bond H a bond NH 0 NH T3e OH
1826 CH S QIc a bond H a bond NH 0 NH T3f OH
1827 CH S QIc a bond H a bond NH 0 NH T3g OH
1828 CH S QIc a bond H a bond NH 0 NH T3h OH
1829 CH S QIc a bond H a bond NH 0 NH T3i OH
1830 CH S QIc a bond H a bond NH 0 NH T3j OH
1831 CH S QIc a bond H a bond NH 0 a bond T3a OH
1832 CH S QIc a bond H a bond NH 0 a bond T3b OH
1833 CH S QIc a bond H a bond NH 0 a bond T3c OH
1834 CH S QIc a bond H a bond NH 0 a bond T3d OH
1835 CH S QIc a bond H a bond NH 0 a bond T3e OH
1836 CH S QIc a bond H a bond NH 0 a bond T3f OH
1837 CH S QIc a bond H a bond NH 0 a bond T3g OH
1838 CH S QIc a bond H a bond NH 0 a bond T3h OH
1839 CH S QIc a bond H a bond NH 0 a bond T3i OH
1840 CH S QIc a bond H a bond NH 0 a bond T3j OH
1841 CH S QIi a bond Me a bond NH S NH T3a OH
1842 CH S QIi a bond Me a bond NH S NH T3b OH
1843 CH S QIi a bond Me a bond NH S NH T3c OH
1844 CH S QIi a bond Me a bond NH S NH T3d OH
1845 CH S QIi a bond Me a bond NH S NH T3e OH
1846 CH S QIi a bond Me a bond NH S NH T3f OH
1847 CH S QIi a bond Me a bond NH S NH T3g OH
1848 CH S QIi a bond Me a bond NH S NH T3h OH
1849 CH S QIi a bond Me a bond NH S NH T3i OH
1850 CH S QIi a bond Me a bond NH S NH T3j OH 1851 CH S QIi a bond Me a bond NH S a bond T3a OH
1852 CH S QIi a bond Me a bond NH S a bond T3b OH
1853 CH S QIi a bond Me a bond NH S a bond T3c OH
1854 CH S QIi a bond Me a bond NH S a bond T3d OH
1855 CH S QIi a bond Me a bond NH S a bond T3e OH
1856 CH S QIi a bond Me a bond NH S a bond T3f OH
1857 CH S QIi a bond Me a bond NH S a bond T3g OH
1858 CH S QIi a bond Me a bond NH S a bond T3h OH
1859 CH S QIi a bond Me a bond NH S a bond T3i OH
1860 CH S QIi a bond Me a bond NH S a bond T3j OH
1861 CH S QIi a bond Me a bond NH 0 NH T3a OH
1862 CH S QIi a bond Me a bond NH 0 NH T3b OH
1863 CH S QIi a bond Me a bond NH 0 NH T3c OH
1864 CH S QIi a bond Me a bond NH 0 NH T3d OH
1865 CH S QIi a bond Me a bond NH 0 NH T3e OH
1866 CH S QIi a bond Me a bond NH 0 NH T3f OH
1867 CH S QIi a bond Me a bond NH 0 NH T3g OH
1868 CH S QIi a bond Me a bond NH 0 NH T3h OH
1869 CH S QIi a bond Me a bond NH 0 NH T3i OH
1870 CH S QIi a bond Me a bond NH 0 NH T3j OH
1871 CH S QIi a bond Me a bond NH 0 a bond T3a OH
1872 CH S QIi a bond Me a bond NH 0 a bond T3b OH
1873 CH S QIi a bond Me a bond NH 0 a bond T3c OH
1874 CH S QIi a bond Me a bond NH 0 a bond T3d OH
1875 CH S QIi a bond Me a bond NH 0 a bond T3e OH
1876 CH S QIi a bond Me a bond NH 0 a bond T3f OH
1877 CH S QIi a bond Me a bond NH 0 a bond T3g OH
1878 CH S QIi a bond Me a bond NH 0 a bond T3h OH
1879 CH S QIi a bond Me a bond NH 0 a bond T3i OH
1880 CH S QIi a bond Me a bond NH 0 a bond T3j OH
1881 CH S QIi a bond H a bond NH S NH T3a OH
1882 CH S QIi a bond H a bond NH S NH T3b OH
1883 CH S QIi a bond H a bond NH S NH T3c OH
1884 CH S QIi a bond H a bond NH S NH T3d OH
1885 CH S QIi a bond H a bond NH S NH T3e OH
1886 CH S QIi a bond H a bond NH S NH T3f OH 1887 CH S QIi a bond H a bond NH S NH T3g OH
1888 CH S QIi a bond H a bond NH S NH T3h OH
1889 CH S QIi a bond H a bond NH S NH T3i OH
1890 CH S QIi a bond H a bond NH S NH T3j OH
5 1891 CH S QIi a bond H a bond NH S a bond T3a OH
1892 CH S QIi a bond H a bond NH S a bond T3b OH
1893 CH S QIi a bond H a bond NH S a bond T3c OH
1894 CH S QIi a bond H a bond NH S a bond T3d OH
1895 CH S QIi a bond H a bond NH S a bond T3e OH
.0 1896 CH S QIi a bond H a bond NH S a bond T3f OH
1897 CH S QIi a bond H a bond NH S a bond T3g OH
1898 CH S QIi a bond H a bond NH S a bond T3h OH
1899 CH S QIi a bond H a bond NH S a bond T3i OH
1900 CH S QIi a bond H a bond NH S a bond T3j OH
.5 1901 CH S QIi a bond H a bond NH 0 NH T3a OH
1902 CH S QIi a bond H a bond NH 0 NH T3b OH
1903 CH S QIi a bond H a bond NH 0 NH T3c OH
1904 CH S QIi a bond H a bond NH 0 NH T3d OH
1905 CH S QIi a bond H a bond NH 0 NH T3e OH
!0 1906 CH S QIi a bond H a bond NH 0 NH T3f OH
1907 CH S QIi a bond H a bond NH 0 NH T3g OH
1908 CH S QIi a bond H a bond NH 0 NH T3h OH
1909 CH S QIi a bond H a bond NH 0 NH T3i OH
1910 CH S QIi a bond H a bond NH 0 NH T3j OH
15 1911 CH S QIi a bond H a bond NH 0 a bond T3a OH
1912 CH S QIi a bond H a bond NH 0 a bond T3b OH
1913 CH S QIi a bond H a bond NH 0 a bond T3c OH
1914 CH S QIi a bond H a bond NH 0 a bond T3d OH
1915 CH S QIi a bond H a bond NH 0 a bond T3e OH iO 1916 CH S QIi a bond H a bond NH 0 a bond T3f OH
1917 CH S QIi a bond H a bond NH 0 a bond T3g OH
1918 CH S QIi a bond H a bond NH 0 a bond T3h OH
1919 CH S QIi a bond H a bond NH 0 a bond T3i OH
1920 CH S QIi a bond H a bond NH 0 a bond T3j OH i5 1921 CH S QIj a bond Me a bond NH S NI { T3a OH
1922 CH S QlJ a bond Me a bond NH S Nli T3b OH 1923 CH S QIj a bond Me a bond NH S NH T3c OH
1924 CH S QIj a bond Me a bond NH S NH T3d OH
1925 CH S QIj a bond Me a bond NH S NH T3e OH
1926 CH S QIj a bond Me a bond NH S NH T3f OH
1927 CH S QIj a bond Me a bond NH S NH T3g OH
1928 CH S QIj a bond Me a bond NH S NH T3h OH
1929 CH S QIj a bond Me a bond NH S NH T3i OH
1930 CH S QIj a bond Me a bond NH S NH T3j OH
1931 CH S QIj a bond Me a bond NH S a bond T3a OH
1932 CH S QIj a bond Me a bond NH S a bond T3b OH
1933 CH S QIj a bond Me a bond NH S a bond T3c OH
1934 CH S QIj a bond Me a bond NH S a bond T3d OH
1935 CH S QIj a bond Me a bond NH S a bond T3e OH
1936 CH S QIj a bond Me a bond NH S a bond T3f OH
1937 CH S Qij a bond Me a bond NH S a bond T3g OH
1938 CH S QIj a bond Me a bond NH S a bond T3h OH
1939 CH S Qij a bond Me a bond NH S a bond T3i OH
1940 CH S Qij a bond Me a bond NH S a bond T3j OH
1941 CH S Qij a bond Me a bond NH 0 NH T3a OH
1942 CH S Qij a bond Me a bond NH 0 NH T3b OH
1943 CH S Qij a bond Me a bond NH 0 NH T3c OH
1944 CH S Qij a bond Me a bond NH 0 NH T3d OH
1945 CH S Qij a bond Me a bond NH 0 NH T3e OH
1946 CH S Qij a bond Me a bond NH 0 NH T3f OH
1947 CH S Qij a bond Me a bond NH 0 NH T3g OH
1948 CH S Qij a bond Me a bond NH 0 NH T3h OH
1949 CH S Qij a bond Me a bond NH 0 NH T3i OH
1950 CH S Qij a bond Me a bond NH 0 NH T3j OH
1951 CH S Qij a bond Me a bond NH 0 a bond T3a OH
1952 CH S Qij a bond Me a bond NH 0 a bond T3b OH
1953 CH S Qij a bond Me a bond NH 0 a bond T3c OH
1954 CH S Qij a bond Me a bond NH 0 a bond T3d OH
1955 CH S Qij a bond Me a bond NH 0 a bond T3e OH
1956 CH S Qij a bond Me a bond NH 0 a bond T3f OH
1957 CH S Qij a bond Me a bo'nd NH 0 a bond T3g OH
1958 CH S Qij a bond Me a bond NH 0 a bond T3h OH 1959 CH S QIj a bond Me a bond NH 0 a bond T3i OH
1960 CH S QIj a bond Me a bond NH 0 a bond T3j OH
1961 CH S QIi a bond H a bond NH S NH T3a OH
1962 CH S QIj a bond H a bond NH S NH T3b OH
1963 CH S QIj a bond H a bond NH S NH T3c OH
1964 CH S QIj a bond H a bond NH S NH T3d OH
1965 CH S QIj a bond H a bond NH S NH T3e OH
1966 CH S QIj a bond H a bond NH S NH T3f OH
1967 CH S QIj a bond H a bond NH S NH T3g OH
1968 CH S QIj a bond H a bond NH S NH T3h OH
1969 CH S QIj a bond H a bond NH S NH T3i OH
1970 CH S QIj a bond H a bond NH S NH T3j OH
1971 CH S QIj a bond H a bond NH S a bond T3a OH
1972 CH S QIj a bond H a bond NH S a bond T3b OH
1973 CH S QIj a bond H a bond NH S a bond T3c OH
1974 CH S QIj a bond H a bond NH S a bond T3d OH
1975 CH S QIj a bond H a bond NH S a bond T3e OH
1976 CH S QIj a bond H a bond NH S a bond T3f OH
1977 CH S QIj a bond H a bond NH S a bond T3g OH
1978 CH S QIj a bond H a bond NH S a bond T3h OH
1979 CH S QIj a bond H a bond NH S a bond T3i OH
1980 CH S QIj a bond H a bond NH S a bond T3j OH
1981 CH S QIj a bond H a bond NH 0 NH T3a OH
1982 CH S QIj a bond H a bond NH 0 NH T3b OH
1983 CH S Qij a bond H a bond NH 0 NH T3c OH
1984 CH S Qlj a bond H a bond NH 0 NH T3d OH
1985 CH S Qlj a bond H a bond NH 0 NH T3e OH
1986 CH S Qlj a bond H a bond NH 0 NH T3f OH
1987 CH S Qlj a bond H a bond NH 0 NH T3g OH
1988 CH S Qlj a bond H a bond NH 0 NH T3h OH
1989 CH S Qlj a bond H a bond NH 0 NH T3i OH
1990 CH S Qlj a bond H a bond NH 0 NH T3j OH
1991 CH S Qlj a bond H a bond NH 0 a bond T3a OH
1992 CH S Qlj a bond H a bond NH 0 a bond T3b OH
1993 CH S Qlj a bond H a bond NH 0 a bond T3c OH
1994 CH S Qlj a bond H a bond NH 0 a bond . T3d OH 1995 CH S Qij a bond H a bond NH 0 a bond T3e OH
1996 CH S Qij a bond H a bond NH 0 a bond T3f OH
1997 CH S Qij a bond H a bond NH 0 a bond T3g OH
1998 CH S Qij a bond H a bond NH 0 a bond T3h OH
1999 CH S Qij a bond H a bond NH 0 a bond T3i OH
2000 CH S Qij a bond H a bond NH 0 a bond T3j OH
2001 CH 0 QIa a bond Me a bond NH S NH T3a OH
2002 CH 0 QIa a bond Me a bond NH S NH T3b OH
2003 CH 0 QIa a bond Me a bond NH S NH T3c OH 2004 CH 0 QIa a bond Me a bond NH S NH T3d OH
2005 CH 0 QIa a bond Me a bond NH S NH T3e OH
2006 CH 0 QIa a bond Me a bond NH S NH T3f OH
2007 CH 0 QIa a bond Me a bond NH S NH T3g OH
2008 CH 0 QIa a bond Me a bond NH S NH T3h OH 2009 CH 0 QIa a bond Me a bond NH S NH T3i OH
2010 CH 0 QIa a bond Me a bond NH S NH T3j OH
2011 CH 0 QIa a bond Me a bond NH S a bond T3a OH
2012 CH 0 QIa a bond Me a bond NH S a bond T3b OH
2013 CH 0 QIa a bond Me a bond NH S a bond T3c OH 2014 CH 0 QIa a bond Me a bond NH S a bond T3d OH
2015 CH 0 QIa a bond Me a bond NH S a bond T3e OH
2016 CH 0 QIa a bond Me a bond NH S a bond T3f OH
2017 CH 0 QIa a bond Me a bond NH S a bond T3g OH
2018 CH 0 QIa a bond Me a bond N S a bond T3h OH 2019 CH 0 QIa a bond Me a bond N S a bond T3i OH
2020 CH 0 QIa a bond Me a bond K S a bond T3j OH
2021 CH 0 QIa a bond Me a bond NH 0 NH T3a OH
2022 CH 0 QIa a bond Me a bond NH 0 NH T3b OH
2023 CH 0 QIa a bond Me a bond NH 0 NH T3c OH 2024 CH 0 QIa a bond Me a bond NH 0 NH T3d OH
2025 CH 0 QIa a bond Me a bond NH 0 NH T3e OH
2026 CH 0 QIa a bond Me a bond NH 0 NH T3f OH
2027 CH 0 QIa a bond Me a bond NH 0 NH T3g OH
2028 CH 0 QIa a bond Me a bond NH 0 NH T3h OH 2029 CH 0 QIa a bond Me a bond NH 0 NH T3i ' OH
2030 CH 0 QIa a bond Me a bond NH 0 NH T3j OH 2031 CH 0 QIa a bond Me a bond NH 0 a bond T3a OH
2032 CH 0 QIa a bond Me a bond NH 0 a bond T3b OH
2033 CH 0 QIa a bond Me a bond NH 0 a bond T3c OH
2034 CH 0 QIa a bond Me a bond NH 0 a bond T3d OH
2035 CH 0 QIa a bond Me a bond NH 0 a bond T3e OH
2036 CH 0 QIa a bond Me a bond NH 0 a bond T3f OH
2037 CH 0 QIa a bond Me a bond NH 0 a bond T3g OH
2038 CH 0 QIa a bond Me a bond NH 0 a bond T3h OH
2039 CH 0 QIa a bond Me a bond NH 0 a bond T3i OH
2040 CH 0 QIa a bond Me a bond NH 0 a bond T3j OH
2041 CH 0 QIa a bond H a bond NH S NH T3a OH
2042 CH 0 QIa a bond H a bond NH S NH T3b OH
2043 CH 0 QIa a bond H a bond NH S NH T3c OH
2044 CH 0 QIa a bond H a bond NH S NH T3d OH
2045 CH 0 QIa a bond H a bond NH S NH T3e OH
2046 CH 0 QIa a bond H a bond NH S NH T3f OH
2047 CH 0 QIa a bond H a bond NH S NH T3g OH
2048 CH 0 QIa a bond H a bond NH S NH T3h OH
2049 CH 0 QIa a bond H a bond NH S NH T3i OH
2050 CH 0 QIa a bond H a bond NH S NH T3j OH
2051 CH 0 QIa a bond H a bond NH S a bond T3a OH
2052 CH 0 QIa a bond H a bond NH S a bond T3b OH
2053 CH 0 QIa a bond H a bond NH S a bond T3c OH
2054 CH 0 QIa a bond H a bond NH S a bond T3d OH
2055 CH 0 QIa a bond H a bond NH S a bond T3e OH
2056 CH 0 QIa a bond H a bond NH S a bond T3f OH
2057 CH 0 QIa a bond H a bond NH S a bond T3g OH
2058 CH 0 QIa a bond H a bond NH S a bond T3h OH
2059 CH 0 QIa a bond H a bond NH S a bond T3i OH
2060 CH 0 QIa a bond H a bond NH S a bond T3j OH
2061 CH 0 QIa a bond H a bond NH 0 NH T3a OH
2062 CH 0 QIa a bond H a bond NH 0 NH T3b OH
2063 CH 0 QIa a bond H a bond NH 0 NH T3c OH
2064 CH 0 QIa a bond H a bond NH 0 NH T3d OH 2065 CH 0 QIa a bond H a bond NH 0 NH T3e OH 2066 CH 0 QIa a bond H a bond NH 0 NH T3f OH 2067 CH 0 QIa a bond H a bond NH 0 NH T3g OH
2068 CH 0 QIa a bond H a bond NH 0 NH T3h OH
2069 CH 0 QIa a bond H a bond NH 0 NH T3i OH
2070 CH 0 QIa a bond H a bond NH 0 NH T3j OH 2071 CH 0 QIa a bond H a bond NH 0 a bond T3a OH
2072 CH 0 QIa a bond H a bond NH 0 a bond T3b OH
2073 CH 0 QIa a bond H a bond NH 0 a bond T3c OH
2074 CH 0 QIa a bond H a bond NH 0 a bond T3d OH
2075 CH 0 QIa a bond H a bond NH 0 a bond T3e OH 2076 CH 0 QIa a bond H a bond NH 0 a bond T3f OH
2077 CH 0 QIa a bond H a bond NH 0 a bond T3g OH
2078 CH 0 QIa a bond H a bond NH 0 a bond T3h OH
2079 CH 0 QIa a bond H a bond NH 0 a bond T3i OH
2080 CH 0 QIa a bond H a bond NH 0 a bond T3j OH 2081 CH 0 QIb a bond Me a bond NH S NH T3a OH
2082 CH 0 QIb a bond Me a bond NH S NH T3b OH
2083 CH 0 QIb a bond Me a bond NH S NH T3c OH
2084 CH 0 QIb a bond Me a bond NH S NH T3d OH
2085 CH 0 QIb a bond Me a bond NH S NH T3e OH 2086 CH 0 QIb a bond Me a bond NH S NH T3f OH
2087 CH 0 QIb a bond Me a bond NH S NH T3g OH
2088 CH 0 QIb a bond Me a bond NH S NH T3h OH
2089 CH 0 QIb a bond Me a bond NH S NH T3i OH
2090 CH 0 QIb a bond Me a bond NH S NH T3j OH 2091 CH 0 QIb a bond Me a bond NH S a bond T3a OH
2092 CH 0 QIb a bond Me a bond NH S a bond T3b OH
2093 CH 0 QIb a bond Me a bond NH S a bond T3c OH
2094 CH 0 QIb a bond Me a bond NH S a bond T3d OH
2095 CH 0 QIb a bond Me a bond NH S a bond T3e OH 2096 CH 0 QIb a bond Me a bond NH S a bond T3f OH
2097 CH 0 QIb a bond Me a bond NH S a bond T3g OH
2098 CH 0 QIb a bond Me a bond NH S a bond T3h OH
2099 CH 0 QIb a bond Me a bond NH S a bond T3i OH
2100 CH 0 QIb a bond Me a bond NH S a bond T3j OH 2101 CH 0 QIb a bond Me a bond NH 0 NH T3a OH
2102 CH 0 QIb a bond Me a bond NH 0 NH T3b OH 2103 CH 0 QIb a bond Me a bond NH 0 NH T3c OH
2104 CH 0 QIb a bond Me a bond NH 0 NH T3d OH
2105 CH 0 QIb a bond Me a bond NH 0 NH T3e OH
2106 CH 0 QIb a bond Me a bond NH 0 NH T3f OH
2107 CH 0 QIb a bond Me a bond NH 0 NH T3g OH
2108 CH 0 QIb a bond Me a bond NH 0 NH T3h OH
2109 CH 0 QIb a bond Me a bond NH 0 NH T3i OH
2110 CH 0 QIb a bond Me a bond NH 0 NH T3j OH
2111 CH 0 QIb a bond Me a bond NH 0 a bond T3a OH
2112 CH 0 QIb a bond Me a bond NH 0 a bond T3b OH
2113 CH 0 QIb a bond Me a bond NH 0 a bond T3c OH
2114 CH 0 QIb a bond Me a bond NH 0 a bond T3d OH
2115 CH 0 QIb a bond Me a bond NH 0 a bond T3e OH
2116 CH 0 QIb a bond Me a bond NH 0 a bond T3f OH
2117 CH 0 QIb a bond Me a bond NH 0 a bond T3g OH
2118 CH 0 QIb a bond Me a bond NH 0 a bond T3h OH
2119 CH 0 QIb a bond Me a bond NH 0 a bond T3i OH
2120 CH 0 QIb a bond Me a bond NH 0 a bond T3j OH
2121 CH 0 QIb a bond H a bond NH S NH T3a OH
2122 CH 0 QIb a bond H a bond NH S NH T3b OH
2123 CH 0 QIb a bond H a bond NH S NH T3c OH
2124 CH 0 QIb a bond H a bond NH S NH T3d OH
2125 CH 0 QIb a bond H a bond NH S NH T3e OH
2126 CH 0 QIb a bond H a bond NH S NH T3f OH
2127 CH 0 QIb a bond H a bond NH S NH T3g OH
2128 CH 0 QIb a bond H a bond NH S NH T3h OH
2129 CH 0 QIb a bond H a bond NH S NH T3i OH
2130 CH 0 QIb a bond H a bond NH S NH T3j OH
2131 CH 0 QIb a bond H a bond NH S a bond T3a OH
2132 CH 0 QIb a bond H a bond NH S a bond T3b OH
2133 CH 0 QIb a bond H a bond NH S a bond T3c OH
2134 CH 0 QIb a bond H a bond NH S a bond T3d OH
2135 CH 0 QIb a bond H a bond NH S a bond T3e OH
2136 CH 0 QIb a bond H a bond NH S a bond T3f OH
2137 CH 0 QIb a bond H a bond NH S a bond T3g OH
2138 CH 0 QIb a bond H a bond NH S a bond T3h OH 2139 CH 0 QIb a bond H a bond NH S a bond T3i OH
2140 CH 0 QIb a bond H a bond NH S a bond T3j OH
2141 CH 0 QIb a bond H a bond NH 0 NH T3a OH
2142 CH 0 QIb a bond H a bond NH 0 NH T3b OH
2143 CH 0 QIb a bond H a bond NH 0 NH T3c OH
2144 CH 0 QIb a bond H a bond NH 0 NH T3d OH
2145 CH 0 QIb a bond H a bond NH 0 NH T3e OH
2146 CH 0 QIb a bond H a bond NH 0 NH T3f OH
2147 CH 0 QIb a bond H a bond NH 0 NH T3g OH
2148 CH 0 QIb a bond H a bond NH 0 NH T3h OH
2149 CH 0 QIb a bond H a bond NH 0 NH T3i OH
2150 CH 0 QIb a bond H a bond NH 0 NH T3j OH
2151 CH 0 QIb a bond H a bond NH 0 a bond T3a OH
2152 CH 0 QIb a bond H a bond NH 0 a bond T3b OH
2153 CH 0 QIb a bond H a bond NH 0 a bond T3c OH
2154 CH 0 QIb a bond H a bond NH 0 a bond T3d OH
2155 CH 0 QIb a bond H a bond NH 0 a bond T3e OH
2156 CH 0 QIb a bond H a bond NH 0 a bond T3f OH
2157 CH 0 QIb a bond H a bond NH 0 a bond T3g OH
2158 CH 0 QIb a bond H a bond NH 0 a bond T3h OH
2159 CH 0 QIb a bond H a bond NH 0 a bond T3i OH
2160 CH 0 QIb a bond H a bond NH 0 a bond T3j OH
2161 CH 0 QIc a bond Me a bond NH S NH T3a OH
2162 CH 0 QIc a bond Me a bond NH S NH T3b OH
2163 CH 0 QIc a bond Me a bond NH S NH T3c OH
2164 CH 0 QIc a bond Me a bond NH S NH T3d OH
2165 CH 0 QIc a bond Me a bond NH S NH T3e OH
2166 CH 0 QIc a bond Me a bond NH S NH T3f OH
2167 CH 0 QIc a bond Me a bond NH S NH T3g OH
2168 CH 0 QIc a bond Me a bond NH S NH T3h OH
2169 CH 0 QIc a bond Me a bond NH S NH T3i OH
2170 CH 0 QIc a bond Me a bond NH S NH T3j OH
2171 CH 0 QIc a bond Me a bond NH S a bond T3a OH
2172 CH 0 QIc a bond Me a bond NH S a bond T3b OH
2173 CH 0 QIc a bond Me a bond NH S a bond T3c OH
2174 CH 0 QIc a bond Me a bond NH S a bond T3d OH 2175 CH 0 QIc a bond Me a bond NH S a bond T3e OH
2176 CH 0 QIc a bond Me a bond NH S a bond T3f OH
2177 CH 0 QIc a bond Me a bond NH S a bond T3g OH
2178 CH 0 QIc a bond Me a bond NH S a bond T3h OH 2179 CH 0 QIc a bond Me a bond NH S a bond T3i OH
2180 CH 0 QIc a bond Me a bond NH S a bond T3j OH
2181 CH 0 QIc a bond Me a bond NH 0 NH T3a OH
2182 CH 0 QIc a bond Me a bond NH 0 NH T3b OH
2183 CH 0 QIc a bond Me a bond NH 0 NH T3c OH 2184 CH 0 QIc a bond Me a bond NH 0 NH T3d OH
2185 CH 0 QIc a bond Me a bond NH 0 NH T3e OH
2186 CH 0 QIc a bond Me a bond NH 0 NH T3f OH
2187 CH 0 QIc a bond Me a bond NH 0 NH T3g OH
2188 CH 0 QIc a bond Me a bond NH 0 NH T3h OH 2189 CH 0 QIc a bond Me a bond NH 0 NH T3i OH
2190 CH 0 QIc a bond Me a bond NH 0 NH T3j OH
2191 CH 0 QIc a bond Me a bond NH 0 a bond T3a OH
2192 CH 0 QIc a bond Me a bond NH 0 a bond T3b OH
2193 CH 0 QIc a bond Me a bond NH 0 a bond T3c OH 2194 CH 0 QIc a bond Me a bond NH 0 a bond T3d OH
2195 CH 0 QIc a bond Me a bond NH 0 a bond T3e OH
2196 CH 0 QIc a bond Me a bond NH 0 a bond T3f OH
2197 CH 0 QIc a bond Me a bond NH 0 a bond T3g OH
2198 CH 0 QIc a bond Me a bond NH 0 a bond T3h OH 2199 CH 0 QIc a bond Me a bond NH 0 a bond T3i OH
2200 CH 0 QIc a bond Me a bond NH 0 a bond T3j OH
2201 CH 0 QIc a bond H a bond NH S NH T3a OH
2202 CH 0 QIc a bond H a bond NH S NH T3b OH
2203 CH 0 QIc a bond H a bond NH S NH T3c OH 2204 CH 0 QIc a bond H a bond NH S NH T3d OH
2205 CH 0 QIc a bond H a bond NH S NH T3e OH
2206 CH 0 QIc a bond H a bond NH S NH T3f OH
2207 CH 0 QIc a bond H a bond NH S NH T3g OH
2208 CH 0 QIc a bond H a bond NH S NH T3h OH 2209 CH 0 QIc a bond H a bond NH S NH T3i OH
2210 CH 0 QIc a bond H a bond NH S NH T3j OH 2211 CH 0 QIc a bond H a bond NH S a bond T3a OH
2212 CH 0 QIc a bond H a bond NH S a bond T3b OH
2213 CH 0 QIc a bond H a bond NH S a bond T3c OH
2214 CH 0 QIc a bond H a bond NH S a bond T3d OH
2215 CH 0 QIc a bond H a bond NH S a bond T3e OH
2216 CH 0 QIc a bond H a bond NH S a bond T3f OH
2217 CH 0 QIc a bond H a bond NH S a bond T3g OH
2218 CH 0 QIc a bond H a bond NH S a bond T3h OH
2219 CH 0 QIc a bond H a bond NH S a bond T3i OH
2220 CH 0 QIc a bond H a bond NH S a bond T3j OH
2221 CH 0 QIc a bond H a bond NH 0 NH T3a OH
2 2222222 C CHH 0 0 Q QIIcc aa bboonndd H H aa bond NH 0 NH T3b OH
2 2222233 C CHH 0 0 Q QIIcc aa bboonndd H H aa bond NH 0 NH T3c OH
2 2222244 C CHH 0 0 Q QIIcc aa bboonndd H H aa bond NH 0 NH T3d OH
2 2222255 C CHH 0 0 Q QIIcc aa bboonndd H H aa bond NH 0 NH T3e OH
2 2222266 C CHH 0 0 Q QIIcc aa bboonndd H H aa bond NH 0 NH T3f OH
2 2222277 C CHH 0 0 Q QIIcc aa bboonndd H H aa bond NH 0 NH T3g OH
2 2222288 C CHH 0 0 Q QIIcc aa bboonndd H H aa bond NH 0 NH T3h OH
2229 CH 0 QIc a bond H a bond NH 0 NH T3i OH
2230 CH 0 QIc a bond H a bond NH 0 NH T3j OH
2231 CH 0 QIc a bond H a bond NH 0 a bond T3a OH
2232 CH 0 QIc a bond H a bond NH 0 a bond T3b OH
2233 CH 0 QIc a bond H a bond NH 0 a bond T3c OH
2234 CH 0 QIc a bond H a bond NH 0 a bond T3d OH
2235 CH 0 QIc a bond H a bond NH 0 a bond T3e OH
2 2223366 C CHH 0 0 Q QIIcc aa bboonndd H H aa bboonndd N NHH 0 0 aa bboonndd T T33ff OH
2 2223377 C CHH 0 0 Q QIIcc aa bboonndd H H aa bboonndd N NHH 0 0 aa bboonndd T T33gg OH
2 2223388 C CHH 0 0 Q QIIcc aa bboonndd H H aa bboonndd N NHH 0 0 aa bboonndd T T33hh OH
2 2223399 C CHH 0 0 Q QIIcc aa bboonndd H H aa bboonndd N NHH 0 0 aa bboonndd T T33ii OH
2 2224400 C CHH 0 0 Q QIIcc aa bboonndd H H aa bboonndd N NHH 0 0 aa bboonndd T T33jj OH
2241 CH 0 QIi a bond Me a bond NH S NH T3a OH
2242 CH 0 QIi a bond Me a bond NH S NH T3b OH
2243 CH 0 QIi a bond Me a bond NH S NH T3c OH
2244 CH 0 QIi a bond Me a bond NH S NH T3d OH
2245 CH 0 QIi a bond Me a bond NH S NH T3e OH
2246 CH 0 QIi a bond Me a bond NH S NH T3f OH 2247 CH 0 QIi a bond Me a bond NH S NH T3g OH
2248 CH 0 QIi a bond Me a bond NH S NH T3h OH
2249 CH 0 QIi a bond Me a bond NH S NH T3i OH
2250 CH 0 QIi a bond Me a bond NH S NH T3j OH 2251 CH 0 QIi a bond Me a bond I S a bond T3a OH
2252 CH 0 QIi a bond Me a bond NH S a bond T3b OH
2253 CH 0 QIi a bond Me a bond NH S a bond T3c OH
2254 CH 0 QIi a bond Me a bond NH S a bond T3d OH
2255 CH 0 QIi a bond Me a bond NH S a bond T3e OH 2256 CH 0 QIi a bond Me a bond NH S a bond T3f OH
2257 CH 0 QIi a bond Me a bond NH S a bond T3g OH
2258 CH 0 QIi a bond Me a bond NH S a bond T3h OH
2259 CH 0 QIi a bond Me a bond NH S a bond T3i OH
2260 CH 0 QIi a bond Me a bond NH S a bond T3j OH 2261 CH 0 QIi a bond Me a bond NH 0 NH T3a OH
2262 CH 0 QIi a bond Me a bond NH 0 NH T3b OH
2263 CH 0 QIi a bond Me a bond NH 0 NH T3c OH
2264 CH 0 QIi a bond Me a bond NH 0 NH T3d OH
2265 CH 0 QIi a bond Me a bond NH 0 NH T3e OH 2266 CH 0 QIi a bond Me a bond NH 0 NH T3f OH
2267 CH 0 QIi a bond Me a bond NH 0 NH T3g OH
2268 CH 0 QIi a bond Me a bond NH 0 NH T3h OH
2269 CH 0 QIi a bond Me a bond NH 0 NH T3i OH
2270 CH 0 QIi a bond Me a bond NH 0 NH T3j OH 2271 CH 0 QIi a bond Me a bond NH 0 a bond T3a OH
2272 CH 0 QIi a bond Me a bond NH 0 a bond T3b OH
2273 CH 0 QIi a bond Me a bond NH 0 a bond T3c OH
2274 CH 0 QIi a bond Me a bond NH 0 a bond T3d OH
2275 CH 0 QIi a bond Me a bond NH 0 a bond T3e OH 2276 CH 0 QIi a bond Me a bond NH 0 a bond T3f OH
2277 CH 0 QIi a bond Me a bond NH 0 a bond T3g OH
2278 CH 0 QIi a bond Me a bond NH 0 a bond T3h OH
2279 CH 0 QIi a bond Me a bond NH 0 a bond T3i OH
2280 CH 0 QIi a bond Me a bond NH 0 a bond T3j OH 2281 CH 0 QIi a bond H a bond NH S NH T3a OH
2282 CH 0 QIi a bond H a bond NH S NH T3b OH 2283 CH 0 QIi a bond H a bond NH S NH T3c OH
2284 CH 0 QIi a bond H a bond NH S NH T3d OH
2285 CH 0 QIi a bond H a bond NH S NH T3e OH
2286 CH 0 QIi a bond H a bond NH S NH T3f OH 2287 CH 0 QIi a bond H a bond NH S NH T3g OH
2288 CH 0 QIi a bond H a bond NH S NH T3h OH
2289 CH 0 QIi a bond H a bond NH S NH T3i OH
2290 CH 0 QIi a bond H a bond NH S NH T3j OH
2291 CH 0 QIi a bond H a bond NH S a bond T3a OH 2292 CH 0 QIi a bond H a bond NH S a bond T3b OH
2293 CH 0 QIi a bond H a bond NH S a bond T3c OH
2294 CH 0 QIi a bond H a bond NH S a bond T3d OH
2295 CH 0 QIi a bond H a bond NH S a bond T3e OH
2296 CH 0 QIi a bond H a bond NH S a bond T3f OH 2297 CH 0 QIi a bond H a bond NH S a bond T3g OH
2298 CH 0 QIi a bond H a bond NH S a bond T3h OH
2299 CH 0 QIi a bond H a bond NH S a bond T3i OH
2300 CH 0 QIi a bond H a bond NH S a bond T3j OH
2301 CH 0 QIi a bond H a bond NH 0 NH T3a OH 2302 CH 0 QIi a bond H a bond NH 0 NH T3b OH
2303 CH 0 QIi a bond H a bond NH 0 NH T3c OH
2304 CH 0 QIi a bond H a bond NH 0 NH T3d OH
2305 CH 0 QIi a bond H a bond NH 0 NH T3e OH
2306 CH 0 QIi a bond H a bond NH 0 NH T3f OH 2307 CH 0 QIi a bond H a bond NH 0 NH T3g OH
2308 CH 0 QIi a bond H a bond NH 0 NH T3h OH
2309 CH 0 QIi a bond H a bond NH 0 NH T3i OH
2310 CH 0 QIi a bond H a bond NH 0 NH T3j OH
2311 CH 0 QIi a bond H a bond NH 0 a bond T3a OH 2312 CH 0 QIi a bond H a bond NH 0 a bond T3b OH
2313 CH 0 QIi a bond H a bond NH 0 a bond T3c OH
2314 CH 0 QIi a bond H a bond NH 0 a bond T3d OH
2315 CH 0 QIi a bond H a bond NH 0 a bond T3e OH
2316 CH 0 QIi a bond H a bond NH 0 a bond T3f OH 2317 CH 0 QIi a bond H a bond NH 0 a bond T3g OH
2318 CH 0 QIi a bond H a bond NH 0 a bond T3h OH 2319 CH 0 QIi a bond H a bond NH 0 a bond T3i OH
2320 CH 0 QIi a bond H a bond NH 0 a bond T3j OH
2321 CH 0 QIj a bond Me a bond NH S NH T3a OH
2322 CH 0 QIj a bond Me a bond NH S NH T3b OH 2323 CH 0 QIj a bond Me a bond NH S NH T3c OH
2324 CH 0 QIj a bond Me a bond NH S NH T3d OH
2325 CH 0 QIj a bond Me a bond NH S NH T3e OH
2326 CH 0 QIj a bond Me a bond NH S NH T3f OH
2327 CH 0 QIj a bond Me a bond NH S NH T3g OH 2328 CH 0 QIj a bond Me a bond NH S NH T3h OH
2329 CH 0 QIj a bond Me a bond NH S NH T3i OH
2330 CH 0 QIj a bond Me a bond NH S NH T3j OH
2331 CH 0 QIj a bond Me a bond NH S a bond T3a OH
2332 CH 0 QIj a bond Me a bond NH S a bond T3b OH 2333 CH 0 QIj a bond Me a bond NH S a bond T3c OH
2334 CH 0 QIj a bond Me a bond NH S a bond T3d OH
2335 CH 0 QIj a bond Me a bond NH S a bond T3e OH
2336 CH 0 QIj a bond Me a bond NH S a bond T3f OH
2337 CH 0 QIj a bond Me a bond NH S a bond T3g OH 2338 CH 0 QIj a bond Me a bond NH S a bond T3h OH
2339 CH 0 QIj a bond Me a bond NH S a bond T3i OH
2340 CH 0 QIj a bond Me a bond NH S a bond T3j OH
2341 CH 0 QIj a bond Me a bond NH 0 NH T3a OH
2342 CH 0 QIj a bond Me a bond NH 0 NH T3b OH 2343 CH 0 QIj a bond Me a bond NH 0 NH T3c OH
2344 CH 0 QIj a bond Me a bond NH 0 NH T3d OH
2345 CH 0 QIj a bond Me a bond NH 0 NH T3e OH
2346 CH 0 QIj a bond Me a bond NH 0 NH T3f OH
2347 CH 0 QIj a bond Me a bond NH 0 NH T3g OH 2348 CH 0 QIj a bond Me a bond NH 0 NH T3h OH
2349 CH 0 QIj a bond Me a bond NH 0 NH T3i OH
2350 CH 0 QIj a bond Me a bond NH 0 NH T3j OH
2351 CH 0 QIj a bond Me a bond NH 0 a bond T3a OH
2352 CH 0 QIj a bond Me a bond NH 0 a bond T3b OH 2353 CH 0 QIj a bond Me a bond NH 0 a bond T3c OH
2354 CH 0 QIj a bond Me a bond NH 0 a bond T3d OH 2355 CH O QIj a bond Me a bond NH 0 a bond T3e OH
2356 CH 0 QIj a bond Me a bond NH 0 a bond T3f OH
2357 CH O QIj a bond Me a bond NH 0 a bond T3g OH
2358 CH O QIj a bond Me a bond NH 0 a bond T3h OH
2 2335599 C CHH O 0 Q QIIjj aa bond Me a bond NH 0 a bond T3i OH
2 2336600 C CHH 0 0 Q QIIjj aa bond Me a bond NH 0 a bond T3j OH
2 2336611 C CHH O 0 Q QIIjj aa bond H a bond NH S NH T3a OH
2 2336622 C CHH 0 0 Q QIIjj aa bond H a bond NH S NH T3b OH
2363 CH 0 QIj a bond H a bond NH S NH T3c OH
2364 CH 0 QIj a bond H a bond NH S NH T3d OH
2365 CH 0 QIj a bond H a bond NH S NH T3e OH
2366 CH 0 QIj a bond H a bond NH S NH T3f OH
2367 CH 0 QIj a bond H a bond NH S NH T3g OH
2368 CH 0 QIj a bond H a bond NH S NH T3h OH
2369 CH 0 QIj a bond H a bond NH S NH T3i OH
2370 CH 0 QIj a bond H a bond NH S NH T3j OH
2371 CH 0 QIj a bond H a bond NH S a bond T3a OH
2372 CH 0 QIj a bond H a bond NH S a bond T3b OH
2373 CH 0 QIj a bond H a bond NH S a bond T3c OH
2374 CH 0 QIj a bond H a bond NH S a bond T3d OH
2375 CH 0 QIj a bond H a bond NH S a bond T3e OH
2376 CH 0 QIj a bond H a bond NH S a bond T3f OH
2377 CH 0 QIj a bond H a bond NH S a bond T3g OH
2378 CH 0 QIj a bond H a bond NH S a bond T3h OH
2379 CH 0 QIj a bond Ή a bond NH S a bond T3i OH
2 2338800 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH S a bond T3j OH
2 2338811 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH 0 NH T3a OH
2 2338822 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH 0 NH T3b OH
2 2338833 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH 0 NH T3c OH
2 2338844 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH 0 NH T3d OH
2 2338855 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH 0 NH T3e OH
2 2338866 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH 0 NH T3f OH
2 2338877 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH 0 NH T3g OH
2 2338888 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH 0 NH T3h OH
2 2338899 C CHH 0 0 Q QlIjj aa bboonndd H H aa bond NH 0 NH T3i OH
2 2339900 C CHH 0 0 Q QIIjj aa bboonndd H H aa bond NH 0 NH T3j . OH 2391 CH 0 Qij a bond H a bond NH 0 a bond T3a OH
2392 CH 0 Qij a bond H a bond NH 0 a bond T3b OH
2393 CH 0 QIj a bond H a bond NH 0 a bond T3c OH
2394 CH 0 Qij a bond H a bond NH 0 a bond T3d OH
2395 CH 0 Qij a bond H a bond NH 0 a bond T3e OH
2396 CH 0 Qij a bond H a bond NH 0 a bond T3f OH
2397 CH 0 Qij a bond H a bond NH 0 a bond T3g OH
2398 CH 0 Qij a bond H a bond NH 0 a bond T3h OH
2399 CH 0 Qij a bond H a bond NH 0 a bond T3i OH 2 2440000 C CHH 0 0 Q QIijj aa bond H a bond NH 0 a bond T3j OH
2401 CMe NMe QIa a bond Me a bond NH S NH T3a OH
2402 CMe NMe QIa a bond Me a bond NH S NH T3b OH
2403 CMe NMe QIa a bond Me a bond NH S NH T3c OH
2404 CMe NMe QIa a bond Me a bond NH S NH T3d OH
2405 CMe NMe QIa a bond Me a bond NH S NH T3e OH
2406 CMe NMe QIa a bond Me a bond NH S NH T3f OH
2407 CMe NMe QIa a bond Me a bond NH S NH T3g OH
2408 CMe NMe QIa a bond Me a bond NH S NH T3h OH
2409 CMe NMe QIa a bond Me a bond NH S NH T3i OH
2410 CMe NMe QIa a bond Me a bond NH S NH T3j OH
2411 CMe NMe QIa a bond Me a bond NH S a bond T3a OH
2412 CMe NMe QIa a bond Me a bond NH S a bond T3b OH
2413 CMe NMe QIa a bond Me a bond NH S a bond T3c OH
2414 CMe NMe QIa a bond Me a bond NH S a bond T3d OH
2415 CMe NMe QIa a bond Me a bond NH S a bond T3e OH
2416 CMe NMe QIa a bond Me a bond NH S a bond T3f OH
2417 CMe NMe QIa a bond Me a bond NH S a bond T3g OH
2418 CMe NMe QIa a bond Me a bond NH S a bond T3h OH
2419 CMe NMe QIa a bond Me a bond NH S a bond T3i OH
2420 CMe NMe QIa a bond Me a bond NH S a bond T3j OH
2421 CMe NMe QIa a bond Me a bond NH 0 NH T3a OH
2422 CMe NMe QIa a bond Me a bond NH 0 NH T3b OH
2423 CMe NMe QIa a bond Me a bond NH 0 NH T3c OH
2424 CMe NMe QIa a bond Me a bond NH 0 NH T3d OH
2425 CMe NMe QIa a bond Me a bond NH 0 NH T3e OH
2426 CMe NMe QIa a bond Me a bond NH 0 NH T3f OH 2427 CMe NMe QIa a bond Me a bond NH 0 Nli T3g OH
2428 CMe NMe QIa a bond Me a bond NH 0 NI 1 T3h OH
2429 CMe NMe QIa a bond Me a bond NH 0 NIi T3i OH
2430 CMe NMe QIa a bond Me a bond NH 0 NH T3j OH
2431 CMe NMe QIa a bond Me a bond NH 0 a bond T3a OH
2432 CMe NMe QIa a bond Me a bond NH 0 a bond T3b OH
2433 CMe NMe QIa a bond Me a bond NH 0 a bond T3c OH
2434 CMe NMe QIa a bond Me a bond NH 0 a bond T3d OH
2435 CMe NMe QIa a bond Me a bond NH 0 a bond T3e OH
2436 CMe NMe QIa a bond Me a bond NH 0 a bond T3f OH
2437 CMe NMe QIa a bond Me a bond NH 0 a bond T3g OH
2438 CMe NMe QIa a bond Me a bond NΉ 0 a bond T3h OH
2439 CMe NMe QIa a bond Me a bond NH 0 a bond T3i OH
2440 CMe NMe QIa a bond Me a bond NH 0 a bond T3j OH
2441 CMe NMe QIa a bond H a bond NH S NH T3a OH
2442 CMe NMe QIa a bond H a bond NH S NH T3b OH
2443 CMe NMe QIa a bond H a bond NH S NH T3c OH
2444 CMe NMe QIa a bond H a bond NH S NH T3d OH
2445 CMe NMe QIa a bond H a bond NH S NH T3e OH
2446 CMe NMe QIa a bond H a bond NH S NH T3f OH
2447 CMe NMe QIa a bond H a bond NH S NH T3g OH
2448 CMe NMe QIa a bond H a bond NH S NH T3h OH
2449 CMe NMe QIa a bond H a bond NH S NH T3i OH
2450 CMe NMe QIa a bond H a bond NH S NH T3j OH
2451 CMe NMe QIa a bond H a bond NH S a bond T3a OH
2452 CMe NMe QIa a bond H a bond NH S a bond T3b OH
2453 CMe NMe QIa a bond H a bond NH S a bond T3c OH
2454 CMe NMe QIa a bond H a bond NH S a bond T3d OH
2455 CMe NMe QIa a bond H a bond NH S a bond T3e OH
2456 CMe NMe QIa a bond H a bond NH S a bond T3f OH
2457 CMe NMe QIa a bond H a bond NH S a bond T3g OH
2458 CMe NMe QIa a bond H a bond NH S a bond T3h OH
2459 CMe NMe QIa a bond H a bond NH S a bond T3i OH
2460 CMe NMe QIa a bond H a bond NH S a bond T3j OH
2461 CMe NMe QIa a bond H a bond NH 0 NH T3a OH
2462 CMe NMe QIa a bond H a bond NH 0 NH T3b OH 2463 CMe NMe QIa a bond H a bond NH O NH T3c OH
2464 CMe NMe QIa a bond H a bond NH 0 NH T3d OH
2465 CMe NMe QIa a bond H a bond NH 0 NH T3e OH
2466 CMe NMe QIa a bond H a bond NH 0 NH T3f OH 2467 CMe NMe QIa a bond H a bond NH 0 NH T3g OH
2468 CMe NMe QIa a bond H a bond NH 0 NH T3h OH
2469 CMe NMe QIa a bond H a bond NH 0 NH T3i OH
2470 CMe NMe QIa a bond H a bond NH 0 NH T3j OH
2471 CMe NMe QIa a bond H a bond NH 0 a bond T3a OH 2472 CMe NMe QIa a bond H a bond NH 0 a bond T3b OH
2473 CMe NMe QIa a bond H a bond NH 0 a bond T3c OH
2474 CMe NMe QIa a bond H a bond NH 0 a bond T3d OH
2475 CMe NMe QIa a bond H a bond NH 0 a bond T3e OH
2476 CMe NMe QIa a bond H a bond NH 0 a bond T3f OH 2477 CMe NMe QIa a bond H a bond NH 0 a bond T3g OH
2478 CMe NMe QIa a bond H a bond NH 0 a bond T3h OH
2479 CMe NMe QIa a bond H a bond NH 0 a bond T3i OH
2480 CMe NMe QIa a bond H a bond NH 0 a bond T3j OH
2481 CMe NMe QIb a bond Me a bond NH S NH T3a OH 2482 CMe NMe QIb a bond Me a bond NH S NH T3b OH
2483 CMe NMe QIb a bond Me a bond NH S NH T3c OH
2484 CMe NMe QIb a bond Me a bond NH S NH T3d OH
2485 CMe NMe QIb a bond Me a bond NH S NH T3e OH
2486 CMe NMe QIb a bond Me a bond NH S NH T3f OH 2487 CMe NMe QIb a bond Me a bond NH S NH T3g OH
2488 CMe NMe QIb a bond Me a bond NH S NH T3h OH
2489 CMe NMe QIb a bond Me a bond NH S NH T3i OH
2490 CMe NMe QIb a bond Me a bond NH S NH T3j OH
2491 CMe NMe QIb a bond Me a bond NH S a bond T3a OH 2492 CMe NMe QIb a bond Me a bond NH S a bond T3b OH
2493 CMe NMe QIb a bond Me a bond NH S a bond T3c OH
2494 CMe NMe QIb a bond Me a bond NH S a bond T3d OH
2495 CMe NMe QIb a bond Me a bond NH S a bond T3e OH
2496 CMe NMe QIb a bond Me a bond NH S a bond T3f OH 2497 CMe NMe QIb a bond Me a bond NH S a bond T3g OH
2498 CMe NMe QIb a bond Me a bond NH S a bond T3h OH 2499 CMe NMe QIb a bond Me a bond NH S a bond T3i OH
2500 CMe NMe QIb a bond Me a bond NH S a bond T3j OH
2501 CMe NMe QIb a bond Me a bond NH 0 NH T3a OH
2502 CMe NMe QIb a bond Me a bond NH 0 NH T3b OH
2503 CMe NMe QIb a bond Me a bond NH 0 NH T3c OH
2504 CMe NMe QIb a bond Me a bond NH 0 NH T3d OH
2505 CMe NMe QIb a bond Me a bond NH 0 NH T3e OH
2506 CMe NMe QIb a bond Me a bond NH 0 NH T3f OH
2507 CMe NMe QIb a bond Me a bond NH 0 NH T3g OH
2508 CMe NMe QIb a bond Me a bond NH 0 NH T3h OH
2509 CMe NMe QIb a bond Me a bond NH 0 NH T3i OH
2510 CMe NMe QIb a bond Me a bond NH 0 NH T3j OH
2511 CMe NMe QIb a bond Me a bond NH 0 a bond T3a OH
2512 CMe NMe QIb a bond Me a bond NH 0 a bond T3b OH
2513 CMe NMe QIb a bond Me a bond NH 0 a bond T3c OH
2514 CMe NMe QIb a bond Me a bond NH 0 a bond T3d OH
2515 CMe NMe QIb a bond Me a bond NH 0 a bond T3e OH
2516 CMe NMe QIb a bond Me a bond NH 0 a bond T3f OH
2517 CMe NMe QIb a bond Me a bond NH 0 a bond T3g OH
2518 CMe NMe QIb a bond Me a bond NH 0 a bond T3h OH
2519 CMe NMe QIb a bond Me a bond NH 0 a bond T3i OH
2520 CMe NMe QIb a bond Me a bond NH 0 a bond T3j OH
2521 CMe NMe QIb a bond H a bond NH S NH T3a OH
2522 CMe NMe QIb a bond H a bond NH S NH T3b OH
2523 CMe NMe QIb a bond H a bond NH S NH T3c OH
2524 CMe NMe QIb a bond H a bond NH S NH T3d OH
2525 CMe NMe QIb a bond H a bond NH S NH T3e OH
2526 CMe NMe QIb a bond H a bond NH S NH T3f OH
2527 CMe NMe QIb a bond a bond NH S NH T3g OH
2528 CMe NMe QIb a bond a bond NH S NH T3h OH
2529 CMe NMe QIb a bond H a bond NH S NH T3i OH
2530 CMe NMe QIb a bond H a bond NH S NH T3j OH
2531 CMe NMe QIb a bond H a bond NH S a bond T3a OH
2532 CMe NMe QIb a bond H a bond NH S a bond T3b OH
2533 CMe NMe QIb a bond H a bond NH S a bond T3c OH
2534 CMe NMe QIb a bond H a bond NH S a bond T3d OH 2535 CMe NMe QIb a bond H a bond NH S a bond T3e OH
2536 CMe NMe QIb a bond H a bond NH S a bond T3f OH
2537 CMe NMe QIb a bond H a bond NH S a bond T3g OH
2538 CMe NMe QIb a bond H a bond NH S a bond T3h OH 2539 CMe NMe QIb a bond H a bond NH S a bond T3i OH
2540 CMe NMe QIb a bond H a bond NH S a bond T3j OH
2541 CMe NMe QIb a bond H a bond NH 0 NH T3a OH
2542 CMe NMe QIb a bond H a bond NH 0 NH T3b OH
2543 CMe NMe QIb a bond H a bond NH 0 NH T3c OH 2544 CMe NMe QIb a bond H a bond NH 0 NH T3d OH
2545 CMe NMe QIb a bond H a bond NH 0 NH T3e OH
2546 CMe NMe QIb a bond H a bond NH 0 NH T3f OH
2547 CMe NMe QIb a bond H a bond NH 0 NH T3g OH
2548 CMe NMe QIb a bond H a bond NH 0 NH T3h OH 2549 CMe NMe QIb a bond H a bond NH 0 NH T3i OH
2550 CMe NMe QIb a bond H a bond NH 0 NH T3j OH
2551 CMe NMe QIb a bond H a bond NH 0 a bond T3a OH
2552 CMe NMe QIb a bond H a bond NH 0 a bond T3b OH
2553 CMe NMe QIb a bond H a bond NH 0 a bond T3c OH 2554 CMe NMe QIb a bond H a bond NH 0 a bond T3d OH
2555 CMe NMe QIb a bond H a bond NH 0 a bond T3e OH
2556 CMe NMe QIb a bond H a bond NH 0 a bond T3f OH
2557 CMe NMe QIb a bond H a bond NH 0 a bond T3g OH
2558 CMe NMe QIb a bond H a bond NH 0 a bond T3h OH 2559 CMe NMe QIb a bond H a bond NH 0 a bond T3i OH
2560 CMe NMe QIb a bond H a bond NH 0 a bond T3j OH
2561 CMe NMe QIc a bond Me a bond NH S NH T3a OH
2562 CMe NMe QIc a bond Me a bond NH S NH T3b OH
2563 CMe NMe QIc a bond Me a bond NH S NH T3c OH 2564 CMe NMe QIc a bond Me a bond NH S N H T3d OH
2565 CMe NMe QIc a bond Me a bond NH S N H T3e OH
2566 CMe NMe QIc a bond Me a bond NH S N H T3f OH
2567 CMe NMe QIc a bond Me a bond NH S NH T3g OH
2568 CMe NMe QIc a bond Me a bond NH S NH T3h OH 2569 CMe NMe QIc a bond Me a bond NH S NH T3i OH
2570 CMe NMe QIc a bond Me a bond NH S NH T3j OH 2571 CMe NMe QIc a bond Me a bond NH S a bond T3a OH
2572 CMe NMe QIc a bond Me a bond NH S a bond T3b OH
2573 CMe NMe QIc a bond Me a bond NH S a bond T3c OH
2574 CMe NMe QIc a bond Me a bond NH S a bond T3d OH 2575' CMe NMe QIc a bond Me a bond NH S a bond T3e OH
2576 CMe NMe QIc a bond Me a bond NH S a bond T3f OH
2577 CMe NMe QIc a bond Me a bond NH S a bond T3g OH
2578 CMe NMe QIc a bond Me a bond NH S a bond T3h OH
2579 CMe NMe QIc a bond Me a bond NH S a bond T3i OH 2580 CMe NMe QIc a bond Me a bond NH S a bond T3j OH
2581 CMe NMe QIc a bond Me a bond NH 0 NH T3a OH
2582 CMe NMe QIc a bond Me a bond NH 0 NH T3b OH
2583 CMe NMe QIc a bond Me a bond NH 0 NH T3c OH
2584 CMe NMe QIc a bond Me a bond NH 0 NH T3d OH 2585 CMe NMe QIc a bond Me a bond NH 0 NH T3e OH
2586 CMe NMe QIc a bond Me a bond NH 0 NH T3f OH
2587 CMe NMe QIc a bond Me a bond NH 0 NH T3g OH
2588 CMe NMe QIc a bond Me a bond NH 0 NH T3h OH
2589 CMe NMe QIc a bond Me a bond NH 0 NH T3i OH 2590 CMe NMe QIc a bond Me a bond NH 0 NH T3j OH
2591 CMe NMe QIc a bond Me a bond NH 0 a bond T3a OH
2592 CMe NMe QIc a bond Me a bond NH 0 a bond T3b OH
2593 CMe NMe QIc a bond Me a bond NH 0 a bond T3c OH
2594 CMe NMe QIc a bond Me a bond NH 0 a bond T3d OH 2595 CMe NMe QIc a bond Me a bond NH 0 a bond T3e OH
2596 CMe NMe QIc a bond Me a bond NH 0 a bond T3f OH
2597 CMe NMe QIc a bond Me a bond NH 0 a bond T3g OH
2598 CMe NMe QIc a bond Me a bond NH 0 a bond T3h OH
2599 CMe NMe QIc a bond Me a bond NH 0 a bond T3i OH 2600 CMe NMe QIc a bond Me a bond NH 0 a bond T3j OH
2601 CMe NMe QIc a bond H a bond NH S NH T3a OH
2602 CMe NMe QIc a bond H a bond NH S NH T3b OH
2603 CMe NMe QIc a bond H a bond NH S NH T3c OH
2604 CMe NMe QIc a bond H a bond NH S NH T3d OH 2605 CMe NMe QIc a bond H a bond NH S NH T3e OH
2606 CMe NMe QIc a bond H a bond NH S NH T3f OH 2607 CMe NMe QIc a bond H a bond NH S NH T3g OH
2608 CMe NMe QIc a bond H a bond NH S NH T3h OH
2609 CMe NMe QIc a bond H a bond NH S NH T3i OH
2610 CMe NMe QIc a bond H a bond NH S NH T3j OH 2611 CMe NMe QIc a bond H a bond NH S a bond T3a OH
2612 CMe NMe QIc a bond H a bond NH S a bond T3b OH
2613 CMe NMe QIc a bond H a bond NH S a bond T3c OH
2614 CMe NMe QIc a bond H a bond NH S a bond T3d OH
2615 CMe NMe QIc a bond H a bond NH S a bond T3e OH 2616 CMe NMe QIc a bond H a bond NH S a bond T3f OH
2617 CMe NMe QIc a bond H a bond NH S a bond T3g OH
2618 CMe NMe QIc a bond H a bond NH S a bond T3h OH
2619 CMe NMe QIc a bond H a bond NH S a bond T3i OH
2620 CMe NMe QIc a bond H a bond NH S a bond T3j OH 2621 CMe NMe QIc a bond H a bond NH O NH T3a OH
2622 CMe NMe QIc a bond H a bond NH O NH T3b OH
2623 CMe NMe QIc a bond H a bond NH 0 NH T3c OH
2624 CMe NMe QIc a bond H a bond NH 0 NH T3d OH
2625 CMe NMe QIc a bond H a bond NH 0 NH T3e OH 2626 CMe NMe QIc a bond H a bond NH 0 NH T3f OH
2627 CMe NMe QIc a bond H a bond NH 0 NH T3g OH
2628 CMe NMe QIc a bond H a bond NH 0 NH T3h OH
2629 CMe NMe QIc a bond H a bond NH 0 NH T3i OH
2630 CMe NMe QIc a bond H a bond NH 0 NH T3j OH 2631 CMe NMe QIc a bond H a bond NH 0 a bond T3a OH
2632 CMe NMe QIc a bond H a bond NH 0 a bond T3b OH
2633 CMe NMe QIc a bond H a bond NH 0 a bond T3c OH
2634 CMe NMe QIc a bond H a bond NH 0 a bond T3d OH
2635 CMe NMe QIc a bond H a bond NH 0 a bond T3e OH 2636 CMe NMe QIc a bond H a bond NH 0 a bond T3f OH
2637 CMe NMe QIc a bond H a bond NH 0 a bond T3g OH
2638 CMe NMe QIc a bond H a bond NH 0 a bond T3h OH
2639 CMe NMe QIc a bond H a bond NH 0 a bond T3i OH
2640 CMe NMe QIc a bond H a bond NH 0 a bond T3j OH 2641 CMe NMe QIi a bond Me a bond NH S NH T3a OH
2642 CMe NMe QIi a bond Me a bond NH S NH T3b OH 2643 CMe NMe QIi a bond Me a bond NH S NH T3c OH
2644 CMe NMe QIi a bond Me a bond NH S NH T3d OH
2645 CMe NMe QIi a bond Me a bond NH S NH T3e OH
2646 CMe NMe QIi a bond Me a bond NH S NH T3f OH 2647 CMe NMe QIi a bond Me a bond NH S NH T3g OH
2648 CMe NMe QIi a bond Me a bond NH S NH T3h OH
2649 CMe NMe QIi a bond Me a bond NH S NH T3i OH
2650 CMe NMe QIi a bond Me a bond NH S NH T3j OH
2651 CMe NMe QIi a bond Me a bond NH S a bond T3a OH 2652 CMe NMe QIi a bond Me a bond NH S a bond T3b OH
2653 CMe NMe QIi a bond Me a bond NH S a bond T3c OH
2654 CMe NMe QIi a bond Me a bond NH S a bond T3d OH
2655 CMe NMe QIi a bond Me a bond NH S a bond T3e OH
2656 CMe NMe QIi a bond Me a bond NH S a bond T3f OH 2657 CMe NMe QIi a bond Me a bond NH S a bond T3g OH
2658 CMe NMe QIi a bond Me a bond NH S a bond T3h OH
2659 CMe NMe QIi a bond Me a bond NH S a bond T3i OH
2660 CMe NMe QIi a bond Me a bond NH S a bond T3j OH
2661 CMe NMe QIi a bond Me a bond NH 0 NH T3a OH 2662 CMe NMe QIi a bond Me a bond NH 0 NH T3b OH
2663 CMe NMe QIi a bond Me a bond NH 0 NH T3c OH
2664 CMe NMe QIi a bond Me a bond NH 0 NH T3d OH
2665 CMe NMe QIi a bond Me a bond NH 0 NH T3e OH
2666 CMe NMe QIi a bond Me a bond NH 0 NH T3f OH 2667 CMe NMe QIi a bond Me a bond NH 0 NH T3g OH
2668 CMe NMe QIi a bond Me a bond NH 0 NH T3h OH
2669 CMe NMe QIi a bond Me a bond NH 0 NH T3i OH
2670 CMe NMe QIi a bond Me a bond NH 0 NH T3j OH
2671 CMe NMe QIi a bond Me a bond NH 0 a bond T3a OH 2672 CMe NMe QIi a bond Me a bond NH 0 a bond T3b OH
2673 CMe NMe QIi a bond Me a bond NH 0 a bond T3c OH
2674 CMe NMe QIi a bond Me a bond NH 0 a bond T3d OH
2675 CMe NMe QIi a bond Me a bond NH 0 a bond T3e OH
2676 CMe NMe QIi a bond Me a bond NH 0 a bond T3f OH 2677 CMe NMe QIi a bond Me a bond NH 0 a bond T3g OH
2678 CMe NMe QIi a bond Me a bond NH 0 a bond T3h OH 2679 CMe NMe QIi a bond Me a bond NH 0 a bond T3i OH
2680 CMe NMe QIi a bond Me a bond NH 0 a bond T3j OH
2681 CMe NMe QIi a bond H a bond NH S NH T3a OH
2682 CMe NMe QIi a bond H a bond NH S NH T3b OH 2683 CMe NMe QIi a bond H a bond' NH S NH T3c OH
2684 CMe NMe QIi a bond H a bond NH S NH T3d OH
2685 CMe NMe QIi a bond H a bond NH S NH T3e OH
2686 CMe NMe QIi a bond H a bond NH S NH T3f OH
2687 CMe NMe QIi a bond H a bond NH S NH T3g OH 2688 CMe NMe QIi a bond H a bond NH S NH T3h OH
2689 CMe NMe QIi a bond H a bond NH S NH T3i OH
2690 CMe NMe QIi a bond H a bond NH S NH T3j OH
2691 CMe NMe QIi a bond H a bond NH S a bond T3a OH
2692 CMe NMe QIi a bond H a bond NH S a bond T3b OH 2693 CMe NMe QIi a bond H a bond NH S a bond T3c OH
2694 CMe NMe QIi a bond H a bond NH S a bond T3d OH
2695 CMe NMe QIi a bond H a bond NH S a bond T3e OH
2696 CMe NMe QIi a bond H a bond NH S a bond T3f OH
2697 CMe NMe QIi a bond H a bond NH S a bond T3g OH 2698 CMe NMe QIi a bond H a bond NH S a bond T3h OH
2699 CMe NMe QIi a bond H a bond NH S a bond T3i OH
2700 CMe NMe QIi a bond H a bond NH S a bond T3j OH
2701 CMe NMe QIi a bond H a bond NH 0 NH T3a OH
2702 CMe NMe QIi a bond H .a bond NH 0 NH T3b OH 2703 CMe NMe QIi a bond H a bond NH 0 NH T3c OH
2704 CMe NMe QIi a bond H a bond NH 0 NH T3d OH
2705 CMe NMe QIi a bond H a bond NH 0 NH T3e OH
2706 CMe NMe QIi a bond H a bond NH 0 NH T3f OH
2707 CMe NMe QIi a bond H a bond NH 0 NH T3g OH 2708 CMe NMe QIi a bond H a bond NH 0 NH T3h OH
2709 CMe NMe QIi a bond H a bond NH 0 NH T3i OH
2710 CMe NMe QIi a bond H a bond NH 0 NH T3j OH
2711 CMe NMe QIi a bond H a bond NH 0 a bond T3a OH
2712 CMe NMe QIi a bond H a bond NH 0 a bond T3b OH 2713 CMe NMe QIi a bond H a bond NH 0 a bond T3c OH
2714 CMe NMe QIi a bond H a bond NH 0 a bond T3d OH 2715 CMe NMe QIi a bond H a bond NH 0 a bond T3e OH
2716 CMe NMe QIi a bond H a bond NH 0 a bond T3f OH
2717 CMe NMe QIi a bond H a bond NH 0 a bond T3g OH
2718 CMe NMe QIi a bond H a bond NH 0 a bond T3h OH
2719 CMe NMe QIi a bond H a bond NH 0 a bond T3i OH
2720 CMe NMe QIi a bond H a bond NH 0 a bond T3j OH
2721 CMe NMe QIj a bond Me a bond NH S NH T3a OH
2722 CMe NMe Qij a bond Me a bond NH S NH T3b OH
2723 CMe NMe QIj a bond Me a bond NH S NH T3c OH
2724 CMe NMe QIj a bond Me a bond NH S NH T3d OH
2725 CMe NMe QIj a bond Me a bond NH S NH T3e OH
2726 CMe NMe QIj a bond Me a bond NH S NH T3f OH
2727 CMe NMe QIj a bond Me a bond NH S NH T3g OH
2728 CMe NMe QIj a bond Me a bond NH S NH T3h OH
2729 CMe NMe QIj a bond Me a bond NH S NH T3i OH
2730 CMe NMe Qij a bond Me a bond NH S NH T3j OH
2731 CMe NMe Qij a bond Me a bond NH S a bond T3a OH
2732 CMe NMe QIj a bond Me a bond NH S a bond T3b OH
2733 CMe NMe Qij a bond Me a bond NH S a bond T3c OH
2734 CMe NMe Qij a bond Me a bond NH S a bond T3d OH
2735 CMe NMe Qij a bond Me a bond NH S a bond T3e OH
2736 CMe NMe Qij a bond Me a bond NH S a bond T3f OH
2737 CMe NMe Qij a bond Me a bond NH S a bond T3g OH
2738 CMe NMe Qij a bond Me a bond NH S a bond T3h OH
2739 CMe NMe Qij a bond Me a bond NH S a bond T3i OH
2740 CMe NMe Qij a bond Me a bond NH S a bond T3j OH
2741 CMe NMe Qij a bond Me a bond NH 0 NH T3a OH
2742 CMe NMe Qij a bond Me a bond NH 0 NH T3b OH
2743 CMe NMe Qij a bond Me a bond NH 0 NH T3c OH
2744 CMe NMe Qij a bond Me a bond NH 0 NH T3d OH
2745 CMe NMe Qij a bond Me a bond NH 0 NH T3e OH
2746 CMe NMe Qij a bond Me a bond NH 0 NH T3f OH
2747 CMe NMe Qij a bond Me a bond NH 0 NH T3g OH
2748 CMe NMe Qij a bond Me a bond NH 0 NH T3h OH
2749 CMe NMe Qij a bond Me a bond NH 0 NH T3i OH
2750 CMe NMe Qij a bond Me a bond NH 0 NH T3j OH 2751 CMe NMe QIj a bond Me a bond NH 0 a bond T3a OH
2752 CMe NMe QIj a bond Me a bond NH 0 a bond T3b OH
2753 CMe NMe QIj a bond Me a bond NH 0 a bond T3c OH
2754 CMe NMe QIj a bond Me a bond NH 0 a bond T3d OH 2755 CMe NMe QIj a bond Me a bond NH 0 a bond T3e OH
2756 CMe NMe QIj a bond Me a bond NH 0 a bond T3f OH
2757 CMe NMe QIj a bond Me a bond NH 0 a bond T3g OH
2758 CMe NMe QIj a bond Me a bond NH 0 a bond T3h OH
2759 CMe NMe QIj a bond Me a bond NH 0 a bond T3i OH 2760 CMe NMe QIj a bond Me a bond NH 0 a bond T3j OH
2761 CMe NMe QIj a bond H a bond NH S NH T3a OH
2762 CMe NMe QIj a bond H a bond NH S NH T3b OH
2763 CMe NMe QIj a bond H a bond NH S NH T3c OH
2764 CMe NMe QIj a bond H a bond NH S NH T3d OH 2765 CMe NMe QIj a bond H a bond NH S NH T3e OH
2766 CMe NMe QIj a bond H a bond NH S NH T3f OH
2767 CMe NMe QIj a bond H a bond NH S NH T3g OH
2768 CMe NMe QIj a bond H a bond NH S NH T3h OH
2769 CMe NMe QIj a bond H a bond NH S NH T3i OH 2770 CMe NMe QIj a bond H a bond NH S NH T3j OH
2771 CMe NMe QIj a bond H a bond NH S a bond T3a OH
2772 CMe NMe QIj a bond H a bond NH S a bond T3b OH
2773 CMe NMe QIj a bond H a bond NH S a bond T3c OH
2774 CMe NMe QIj a bond H a bond NH S a bond T3d OH 2775 CMe NMe QIj a bond H a bond NH S a bond T3e OH
2776 CMe NMe QIj a bond H a bond NH S a bond T3f OH
2777 CMe NMe QIj a bond H a bond NH S a bond T3g OH
2778 CMe NMe QIj a bond H a bond NH S a bond T3h OH
2779 CMe NMe QIj a bond H a bond NH S a bond T3i OH 2780 CMe NMe QIj a bond H a bond NH S a bond T3j OH
2781 CMe NMe QIj a bond H a bond NH 0 NH T3a OH
2782 CMe NMe QIj a bond H a bond NH 0 NH T3b OH
2783 CMe NMe QIj a bond H a bond NH 0 NH T3c OH
2784 CMe NMe QIj a bond H a bond NH 0 NH T3d OH 2785 CMe NMe QIj a bond H a bond NH 0 NH T3e OH 2786 CMe NMe QIj a bond H a bond NH 0 NH T3f OH 2787 CMe NMe QIj a bond H a bond NH 0 NH T3g OH
2788 CMe NMe QIj a bond H a bond NH 0 NH T3h OH
2789 CMe NMe QIj a bond H a bond NH 0 NH T3i OH
2790 CMe NMe QIj a bond H a bond NH 0 NH T3j OH 2791 CMe NMe QIj a bond H a bond' NH 0 a bond T3a OH
2792 CMe NMe QIj a bond H a bond NH 0 a bond T3b OH
2793 CMe NMe QIj a bond H a bond NH 0 a bond T3c OH
2794 CMe NMe QIj a bond H a bond NH 0 a bond T3d OH
2795 CMe NMe QIj a bond H a bond NH 0 a bond T3e OH 2796 CMe NMe QIj a bond H a bond NH 0 a bond T3f OH
2797 CMe NMe QIj a bond H a bond NH 0 a bond T3g OH
2798 CMe NMe QIj a bond H a bond NH 0 a bond T3h OH
2799 CMe NMe QIj a bond H a bond NH 0 a bond T3i OH
2800 CMe NMe QIj a bond H a bond NH 0 a bond T3j OH 2801 CMe S QIa a bond Me a ond NH S NH T3a OH
2802 CMe S QIa a bond Me a ond NH S NH T3b OH
2803 CMe S QIa a bond Me a bond NH S NH T3c OH
2804 CMe S QIa a bond Me a bond NH S NH T3d OH
2805 CMe S QIa a bond Me a bond NH S NH T3e OH
2806 CMe S QIa a bond Me a bond NH S NH T3f OH
2807 CMe S QIa a bond Me a bond NH S NH T3g OH
2808 CMe S QIa a bond Me a bond NH S NH T3h OH
2809 CMe S QIa a bond Me a bond NH S NH T3i OH
2810 CMe S QIa a bond Me a bond NH S NH T3j OH
2811 CMe S QIa a bond Me a bond NH S a bond T3a OH
2812 CMe S QIa a bond Me a bond NH S a bond T3b OH
2813 CMe S 01a a bond Me a bond NH S a bond T3c OH
2814 CMe S QIa a bond Me a bond NH S a bond T3d OH
2815 CMe S QIa a bond Me a bond NH S a bond T3e OH
2816 CMe S QIa a bond Me a bond NH S a bond T3f OH
2817 CMe S QIa a bond Me a bond NH S a bond T3g OH
2818 CMe S QIa a bond Me a bond NH S a bond T3h OH
2819 CMe S QIa a bond Me a bond NH S a bond T3i OH
2820 CMe S QIa a bond Me a bond NH S a bond T3j OH
2821 CMe S QIa a bond Me a bond NH 0 NH T3a OH
2822 CMe S QIa a bond Me a bond NH 0 NH T3b OH 2823 CMe S QIa a bond Me a bond NH 0 NH T3c OH
2824 CMe S QIa a bond Me a bond NH 0 NH T3d OH
2825 CMe S QIa a bond Me a bond NH 0 NH T3e OH
2826 CMe S QIa a bond Me a bond NH 0 NH T3f OH
2827 CMe S QIa a bond Me a bond 'NH 0 NH T3g OH
2828 CMe S QIa a bond Me a bond NH 0 NH T3h OH
2829 CMe S QIa a bond Me a bond NH 0 NH T3i OH
2830 CMe S QIa a bond Me a bond NH 0 NH T3j OH
2831 CMe S QIa a bond Me a bond NH 0 a bond T3a OH
2832 CMe S QIa a bond Me a bond NH 0 a bond T3b OH
2833 CMe S QIa a bond Me a bond NH 0 a bond T3c OH
2834 CMe S QIa a bond Me a bond NH 0 a bond T3d OH
2835 CMe S QIa a bond Me a bond NH 0 a bond T3e OH
2836 CMe S QIa a bond Me a bond NH 0 a bond T3f OH
2837 CMe S QIa a bond Me a bond NH 0 a bond T3g OH
2838 CMe S QIa a bond Me a bond NH 0 a bond T3h OH
2839 CMe S QIa a bond Me a bond NH 0 a bond T3i OH
2840 CMe S QIa a bond Me a bond NH 0 a bond T3j OH
2841 CMe S QIa a bond H a bond NH S NH T3a OH
2842 CMe S QIa a bond H a bond NH S NH T3b OH
2843 CMe S QIa a bond H a bond NH S NH T3c OH
2844 CMe S QIa a bond H a bond NH S NH T3d OH
2845 CMe S QIa a bond H a bond NH S NH T3e OH
2846 CMe S QIa a bond H a bond NH S NH T3f OH
2847 CMe S QIa a bond H a bond NH S NH T3g OH
2848 CMe S QIa a bond H a bond NH S NH T3h OH
2849 CMe S QIa a bond H a bond NH S NH T3i OH
2850 CMe S QIa a bond H a bond NH S NH T3j OH
2851 CMe S QIa a bond H a bond NH S a bond T3a OH
2852 CMe S QIa a bond H a bond NH S a bond T3b OH
2853 CMe S QIa a bond H a bond NH S a bond T3c OH
2854 CMe S QIa a bond H a bond NH S a bond T3d OH
2855 CMe S QIa a bond H a bond NH S a bond T3e OH
2856 CMe S QIa a bond H a bond NH S a bond T3f OH
2857 CMe S QIa a bond H a bond NH S a bond T3g OH
2858 CMe S QIa a bond H a bond NH S a bond T3h OH 2859 CMe S QIa a bond H a bond NH S a bond T3i OH
2860 CMe S QIa a bond H a bond NH S a bond T3j OH
2861 CMe S QIa a bond H a bond NH 0 NH T3a OH
2862 CMe S QIa a bond H a bond NH 0 NH T3b OH
2863 CMe S QIa a bond H a bond 'NH 0 NH T3c OH
2864 CMe S QIa a bond H a bond NH 0 NH T3d OH
2865 CMe S QIa a bond H a bond NH 0 NH T3e OH
2866 CMe S QIa a bond H a bond NH 0 NH T3f OH
2867 CMe S QIa a bond H a bond NH 0 NH T3g OH
2868 CMe S QIa a bond H a bond NH 0 NH T3h OH
2869 CMe S QIa a bond H a bond NH 0 NH T3i OH
2870 CMe S QIa a bond H a bond NH 0 NH T3j OH
2871 CMe S QIa a bond H a bond NH 0 a bond T3a OH
2872 CMe S QIa a bond H a bond NH 0 a bond T3b OH
2873 CMe S QIa a bond H a bond NH 0 a bond T3c OH
2874 CMe S QIa a bond H a bond NH 0 a bond T3d OH
2875 CMe S QIa a bond H a bond NH 0 a bond T3e OH
2876 CMe S QIa a bond H a bond NH 0 a bond T3f OH
2877 CMe S QIa a bond H a bond NH 0 a bond T3g OH
2878 CMe S QIa a bond H a bond NH 0 a bond T3h OH
2879 CMe S QIa a bond H a bond NH 0 a bond T3i OH
2880 CMe S QIa a bond H a bond NH 0 a bond T3j OH
2881 CMe S QIb a bond Me a bond NH S NH T3a OH
2882 CMe S QIb a bond Me a bond NH S NH T3b OH
2883 CMe S QIb a bond Me a bond NH S NH T3c OH
2884 CMe S QIb a bond Me a bond NH S NH T3d OH
2885 CMe S QIb a bond Me a bond NH S NH T3e OH
2886 CMe S QIb a bond Me a bond NH S NH T3f OH
2887 CMe S QIb a bond Me a bond NH S NH T3g OH
2888 CMe S QIb a bond Me a bond NH S NH T3h OH
2889 CMe S QIb a bond Me a bond NH S NH T3i OH
2890 CMe S QIb a bond Me a bond NH S NH T3j OH
2891 CMe S QIb a bond Me a bond NH S a bond T3a OH
2892 CMe S QIb a bond Me a bond NH S a bond T3b OH
2893 CMe S QIb a bond Me a bond NH S a bond T3c OH
2894 CMe S QIb a bond Me a bond NH S a bond T3d OH 2895 CMe S QIb a bond Me a bond NH S a bond T3e OH
2896 CMe S QIb a bond Me a bond NH S a bond T3f OH
2897 CMe S QIb a bond Me a bond NH S a bond T3g OH
2898 CMe S QIb a bond Me a bond NH S a bond T3h OH
2899 CMe S QIb a bond Me a bond 'NH S a bond T3i OH
2900 CMe S QIb a bond Me a bond NH S a bond T3j OH
2901 CMe S QIb a bond Me a bond NH 0 NH T3a OH
2902 CMe S QIb a bond Me a bond NH 0 NH T3b OH
2903 CMe S QIb a bond Me a bond NH 0 NH T3c OH
2904 CMe S QIb a bond Me a bond NH 0 NH T3d OH
2905 CMe S QIb a bond Me a bond NH 0 NH T3e OH
2906 CMe S QIb a bond Me a bond NH 0 NH T3f OH
2907 CMe S QIb a bond Me a bond NH 0 NH T3g OH
2908 CMe S QIb a bond Me a bond NH 0 NH T3h OH
2909 CMe S QIb a bond Me a bond NH 0 NH T3i OH
2910 CMe S QIb a bond Me a bond NH 0 NH T3j OH
2911 CMe S QIb a bond Me a bond NH 0 a bond T3a OH
2912 CMe S QIb a bond Me a bond NH 0 a bond T3b OH
2913 CMe S QIb a bond Me a bond NH 0 a bond T3c OH
2914 CMe S QIb a bond Me a bond NH 0 a bond T3d OH
2915 CMe S QIb a bond Me a bond NH 0 a bond T3e OH
2916 CMe S QIb a bond Me a bond NH 0 a bond T3f OH
2917 CMe S QIb a bond Me a bond NH 0 a bond T3g OH
2918 CMe S QIb a bond Me a bond NH 0 a bond T3h OH
2919 CMe S QIb a bond Me a bond NH 0 a bond T3i OH
2920 CMe S QIb a bond Me a bond NH 0 a bond T3j OH
2921 CMe S QIb a bond H a bond NH S NH T3a OH
2922 CMe S QIb a bond H a bond NH S NH T3b OH
2923 CMe S QIb a bond H a bond NH S NH T3c OH
2924 CMe S QIb a bond H a bond NH S NH T3d OH
2925 CMe S QIb a bond H a bond NH S NH T3e OH
2926 CMe S QIb a bond H a bond NH S NH T3f OH
2927 CMe S QIb a bond H a bond NH S NH T3g OH
2928 CMe S QIb a bond H a bond NH S NH T3h OH
2929 CMe S QIb a bond H a bond NH S NH T3i OH
2930 CMe S QIb a bond H a bond NH S NH T3j OH 2931 CMe S QIb a bond H a bond NH S a bond T3a OH
2932 CMe S QIb a bond H a bond NH S a bond T3b OH
2933 CMe S QIb a bond H a bond NH S a bond T3c OH
2934 CMe S QIb a bond H a bond NH S a bond T3d OH
2935 CMe S QIb a bond H a bond 'NH S a bond T3e OH
2936 CMe S QIb a bond H a bond NH S a bond T3f OH
2937 CMe S QIb a bond H a bond NH S a bond T3g OH
2938 CMe S QIb a bond H a bond NH S a bond T3h OH
2939 CMe S QIb a bond H a bond NH S a bond T3i OH
2940 CMe S QIb a bond H a bond NH S a bond T3j OH
2941 CMe S QIb a bond H a bond NH 0 NH T3a OH
2942 CMe S QIb a bond H a bond NH 0 NH T3b OH
2943 CMe S QIb a bond H a bond NH 0 NH T3c OH
2944 CMe S QIb a bond H a bond NH 0 NH T3d OH
2945 CMe S QIb a bond H a bond NH 0 NH T3e OH
2946 CMe S QIb a bond H a bond NH 0 NH T3f OH
2947 CMe S QIb a bond H a bond NH 0 NH T3g OH
2948 CMe S QIb a bond H a bond NH 0 NH T3h OH
2949 CMe S QIb a bond H a bond NH 0 NH T3i OH
2950 CMe S QIb a bond H a bond NH 0 NH T3j OH
2951 CMe S QIb a bond H a bond NH 0 a bond T3a OH
2952 CMe S QIb a bond H a bond NH 0 a bond T3b OH
2953 CMe S QIb a bond H a bond NH 0 a bond T3c OH
2954 CMe S QIb a bond H a bond NH 0 a bond T3d OH
2955 CMe S QIb a bond H a bond NH 0 a bond T3e OH
2956 CMe S QIb a bond H a bond NH 0 a bond T3f OH
2957 CMe S QIb a bond H a bond NH' 0 a bond T3g OH
2958 CMe S QIb a bond H a bond NH 0 a bond T3h OH
2959 CMe S QIb a bond H a bond NH 0 a bond T3i OH
2960 CMe S QIb a bond H a bond NH 0 a bond T3j OH
2961 CMe S QIc a bond Me a bond NH S NH T3a OH
2962 CMe S QIc a bond Me a bond NH S Nl 1 T3b OH
2963 CMe S QIc a bond Me a bond NH S NH T3c OH
2964 CMe S QIc a bond Me a bond NH S NH T3d OH
2965 CMe S QIc a bond Me a bond NH S Nf 1 T3e OH
2966 CMe S QIc a bond Me a bond NH S Nl { T3f OH 2967 CMe S QIc a bond Me a bond NH S NH T3g OH
2968 CMe S QIc a bond Me a bond NH S NH T3h OH
2969 CMe S QIc a bond Me a bond NH S NH T3i OH
2970 CMe S QIc a bond Me a bond NH S NH T3j OH
2971 CMe S QIc a bond Me a bond " NH S a bond T3a OH
2972 CMe S QIc a bond Me a bond NH S a bond T3b OH
2973 CMe S QIc a bond Me a bond NH S a bond T3c OH
2974 CMe S QIc a bond Me a bond NH S a bond T3d OH
2975 CMe S QIc a bond Me a bond NH S a bond T3e OH
2976 CMe S QIc a bond Me a bond NH S a bond T3f OH
2977 CMe S QIc a bond Me a bond NH S a bond T3g OH
2978 CMe S QIc a bond Me a bond NH S a bond T3h OH
2979 CMe S QIc a bond Me a bond NH S a bond T3i OH
2980 CMe S QIc a bond Me a bond NH S a bond T3j OH
2981 CMe S QIc a bond Me a bond NH 0 NH T3a OH
2982 CMe S QIc a bond Me a bond NH 0 NH T3b OH
2983 CMe S QIc a bond Me a bond NH 0 NH T3c OH
2984 CMe S QIc a bond Me a bond NH 0 NH T3d OH
2985 CMe S QIc a bond Me a bond NH 0 NH T3e OH
2986 CMe S QIc a bond Me a bond NH 0 NH T3f OH
2987 CMe S QIc a bond Me a bond NH 0 NH T3g OH
2988 CMe S QIc a bond Me a bond NH 0 NH T3h OH
2989 CMe S QIc a bond Me a bond NH 0 NH T3i OH
2990 CMe S QIc a bond Me a bond NH 0 NH T3j OH
2991 CMe S QIc a bond Me a bond NH 0 a bond T3a OH
2992 CMe S QIc a bond Me a bond NH 0 a bond T3b OH
2993 CMe S QIc a bond Me a bond NH 0 a bond T3c OH
2994 CMe S QIc a bond Me a bond NH 0 a bond T3d OH
2995 CMe S QIc a bond Me a bond NH 0 a bond T3e OH
2996 CMe S QIc a bond Me a bond NH 0 a bond T3f OH
2997 CMe S QIc a bond Me a bond NH 0 a bond T3g OH
2998 CMe S QIc a bond Me a bond NH 0 a bond T3h OH
2999 CMe S QIc a bond Me a bond NH 0 a bond T3i OH
3000 CMe S QIc a bond Me a bond NH 0 a bond T3j OH
3001 CMe S QIc a bond H a bond NH S NH T3a OH
3002 CMe S QIc a bond H a bond NH S NH T3b OH 3003 CMe S QIc a bond H a bond NH S NH T3c OH
3004 CMe S QIc a bond H a bond NH S NH T3d OH
3005 CMe S QIc a bond H a bond NH S NH T3e OH
3006 CMe S QIc a bond H a bond NH S NH T3f OH
3007 CMe S QIc a bond H a bond NH S NH T3g OH
3008 CMe S QIc a bond H a bond NH S NH T3h OH
3009 CMe S QIc a bond H a bond NH S NH T3i OH
3010 CMe S QIc a bond H a bond NH S NH T3j OH
3011 CMe S QIc a bond H a bond NH S a bond T3a OH
3012 CMe S QIc a bond H a bond NH S a bond T3b OH
3013 CMe S QIc a bond H a bond NH S a bond T3c OH
3014 CMe S QIc a bond H a bond NH S a bond T3d OH
3015 CMe S QIc a bond H a bond NH S a bond T3e OH
3016 CMe S QIc a bond H a bond NH S a bond T3f OH
3017 CMe S QIc a bond H a bond NH S a bond T3g OH
3018 CMe S QIc a bond H a bond NH S a bond T3h OH
3019 CMe S QIc a bond H a bond NH S a bond T3i OH
3020 CMe S QIc a bond H a bond NH S a bond T3j OH
3021 CMe S QIc a bond H a bond NH 0 NH T3a OH
3022 CMe S QIc a bond H a bond NH 0 NH T3b OH
3023 CMe S QIc a bond H a bond NH 0 NH T3c OH
3024 CMe S QIc a bond H a bond NH 0 NH T3d OH
3025 CMe S QIc a bond H a bond NH 0 NH T3e OH
3026 CMe S QIc a bond H a bond NH 0 NH T3f OH
3027 CMe S QIc a bond H a bond NH 0 NH T3g OH
3028 CMe S QIc a bond H a bond NH 0 NH T3h OH
3029 CMe S QIc a bond H a bond NH 0 NH T3i OH
3030 CMe S QIc a bond H a bond NH 0 NH T3j OH
3031 CMe S QIc a bond H a bond NH 0 a bond T3a OH
3032 CMe S QIc a bond H a bond NH 0 a bond T3b OH
3033 CMe S QIc a bond H a bond NH 0 a bond T3c OH
3034 CMe S QIc a bond H a bond NH 0 a bond T3d OH
3035 CMe S QIc a bond H a bond NH 0 a bond T3e OH
3036 CMe S QIc a bond H a bond NH 0 a bond T3f OH
3037 CMe S QIc a bond H a bond NH 0 a bond T3g OH
3038 CMe S QIc a bond H a bond NH 0 a bond T3h OH 3039 CMe S QIc a bond H a bond NH 0 a bond T3i OH
3040 CMe S QIc a bond H a bond NH 0 a bond T3j OH
3041 CMe S QIi a bond Me a bond NH S NH T3a OH
3042 CMe S QIi a bond Me a bond NH S NH T3b OH
3043 CMe S QIi a bond Me a bond "NH S NH T3c OH
3044 CMe S QIi a bond Me a bond NH S NH T3d OH
3045 CMe S QIi a bond Me a bond NH S NH T3e OH
3046 CMe S QIi a bond Me a bond NH S NH T3f OH
3047 CMe S QIi a bond Me a bond NH S NH T3g OH
3048 CMe S QIi a bond Me a bond NH S NH T3h OH
3049 CMe S QIi a bond Me a bond NH S NH T3i OH
3050 CMe S QIi a bond Me a bond NH S NH T3j OH
3051 CMe S QIi a bond Me a bond NH S a bond T3a OH
3052 CMe S QIi a bond Me a bond NH S a bond T3b OH
3053 CMe S QIi a bond Me a bond NH S a bond T3c OH
3054 CMe S QIi a bond Me a bond NH S a bond T3d OH
3055 CMe S QIi a bond Me a bond NH S a bond T3e OH
3056 CMe S QIi a bond Me a bond NH S a bond T3f OH
3057 CMe S QIi a bond Me a bond NH S a bond T3g OH
3058 CMe S QIi a bond Me a bond NH S a bond T3h OH
3059 CMe S QIi a bond Me a bond NH S a bond T3i OH
3060 CMe S QIi a bond Me a bond NH S a bond T3j OH
3061 CMe S QIi a bond Me a bond NH 0 NH T3a OH
3062 CMe S QIi a bond Me a bond NH 0 NH T3b OH
3063 CMe S QIi a bond Me a bond NH 0 NH T3c OH
3064 CMe S QIi a bond Me a bond NH 0 NH T3d OH
3065 CMe S QIi a bond Me a bond NH 0 NH T3e OH
3066 CMe S QIi a bond Me a bond NH 0 NH T3f OH
3067 CMe S QIi a bond Me a bond NH 0 NH T3g OH
3068 CMe S QIi a bond Me a bond NH 0 NH T3h OH
3069 CMe S QIi a bond Me a bond NH 0 NH T3i OH
3070 CMe S QIi a bond Me a bond NH 0 NH T3j OH
3071 CMe S QIi a bond Me a bond NH 0 a bond T3a OH
3072 CMe S QIi a bond Me a bond NH 0 a bond T3b OH
3073 CMe S QIi a bond Me a bond NH 0 a bond T3c OH
3074 CMe S QIi a bond Me a bond NH 0 a bond T3d OH 3075 CMe S QIi a bond Me a bond NH 0 a bond T3e OH
3076 CMe S QIi a bond Me a bond NH 0 a bond T3f OH
3077 CMe S QIi a bond Me a bond NH 0 a bond T3g OH
3078 CMe S QIi a bond Me a bond NH 0 a bond T3h OH
3079 ' CMe S QIi a bond Me a bond 'NH 0 a bond T3i OH
3080 CMe S QIi a bond Me a bond NH 0 a bond T3j OH
3081 CMe S QIi a bond H a bond NH S NH T3a OH
3082 CMe S QIi a bond H a bond NH S NH T3b OH
3083 CMe S QIi a bond H a bond NH S NH T3c OH
3084 CMe S QIi a bond H a bond NH S NH T3d OH
3085 CMe S QIi a bond H a bond NH S NH T3e OH
3086 CMe S QIi a bond H a bond NH S NH T3f OH
3087 CMe S QIi a bond H a bond NH S NH T3g OH
3088 CMe S QIi a bond H a bond NH S NH T3h OH
3089 CMe S QIi a bond H a bond NH S NH T3i OH
3090 CMe .S QIi a bond H a bond NH S NH T3j OH
3091 CMe S QIi a bond H a bond NH S a bond T3a OH
3092 CMe S QIi a bond H a bond NH S a bond T3b OH
3093 CMe S QIi a bond H a bond NH S a bond T3c OH
3094 CMe S QIi a bond H a bond NH S a bond T3d OH
3095 CMe S QIi a bond H a bond NH S a bond T3e OH
3096 CMe S QIi a bond H a bond NH S a bond T3f OH
3097 CMe S QIi a bond H a bond NH S a bond T3g OH
3098 CMe S QIi a bond H a bond NH S a bond T3h OH
3099 CMe S QIi a bond H a bond NH S a bond T3i OH
3100 CMe S QIi a bond H a bond NH S a bond T3j OH
3101 CMe S QIi a bond H a bond NH 0 NH T3a OH
3102 CMe S QIi a bond H a bond NH 0 NH T3b OH
3103 CMe S QIi a bond H a bond NH 0 NH T3c OH
3104 CMe S QIi a bond H a bond NH 0 NH T3d OH
3105 CMe S QIi a bond -H a bond NH 0 NH T3e OH
3106 CMe S QIi a bond H a ' bond NH 0 NH T3f OH
3107 CMe S QIi a bond H a bond NH 0 NH T3g OH
3108 CMe S QIi a bond H a bond NH 0 NH T3h OH
3109 CMe S QIi a bond H a bond NH 0 NH T3i OH
3110 CMe S QIi a bond H a bond NH 0 NH T3j OH 3111 CMe S QIi a bond H a bond NH 0 a bond T3a OH
3112 CMe S QIi a bond H a bond NH 0 a bond T3b OH
3113 CMe S QIi a bond H a bond NH 0 a bond T3c OH
3114 CMe S QIi a bond H a bond NH 0 a bond T3d OH 3115 CMe S QIi a bond H a bond NH 0 a bond T3e OH
3116 CMe S QIi a bond H a bond NH 0 a bond T3f OH
3117 CMe S QIi a bond H a bond NH 0 a bond T3g OH
3118 CMe S QIi a bond H a bond NH 0 a bond T3h OH
3119 CMe S QIi a bond H a bond NH 0 a bond T3i OH 3120 CMe S QIi a bond H a bond NH 0 a bond T3j OH
3121 CMe S QIj a bond Me a bond NH S NH T3a OH
3122 CMe S QIj a bond Me a bond NH S NH T3b OH
3123 CMe S QIj a bond Me a bond NH S NH T3c OH
3124 CMe S QIj a bond Me a bond NH S NH T3d OH 3125 CMe S QIj a bond Me a bond NH S NH T3e OH
3126 CMe S QIj a bond Me a bond NH S NH T3f OH
3127 CMe S QIj a bond Me a bond NH S NH T3g OH
3128 CMe S QIj a bond Me a bond NH S NH T3h OH
3129 CMe S QIj a bond Me a bond NH S NH T3i OH 3130 CMe S QIj a bond Me a bond NH S NH T3j OH
3131 CMe S QIj a bond Me a bond NH S a bond T3a OH
3132 CMe S QIj a bond Me a bond NH S a bond T3b OH
3133 CMe S QIj a bond Me a bond NH S a bond T3c OH
3134 CMe S QIj a bond Me a bond NH S a bond T3d OH 3135 CMe S QIj a bond Me a bond NH S a bond T3e OH
3136 CMe S QIj a bond Me a bond NH S a bond T3f OH
3137 CMe S QIj a bond Me a bond NH S a bond T3g OH
3138 CMe S QIj a bond Me a bond NH S a bond T3h OH
3139 CMe S QIj a bond Me a bond NH S a bond T3i OH 3140 CMe S QIj a bond Me a bond NH S a bond T3j OH
3141 CMe S QIj a bond Me a bond NH 0 NH T3a OH
3142 CMe S QIj a bond Me a bond NH 0 NH T3b OH
3143 CMe S QIj a bond Me a bond NH 0 NH T3c OH
3144 CMe S QIj a bond Me a bond NH 0 NH T3d OH 3145 CMe S QIj a bond Me a bond NH 0 NH T3e OH
3146 CMe S QIj a bond Me a bond NH 0 NH T3f OH 3147 CMe S QIj a bond Me a bond NH 0 NIi T3g OH
3148 CMe S QIj a bond Me a bond NH 0 Nl 1 T3h OH
3149 CMe S QIj a bond Me a bond NH 0 NIi T
Figure imgf000502_0001
OH
3150 CMe S QIj a bond Me a bond NH 0 NIi T3j OH
3151 CMe S QIj a bond Me a bond 'NH 0 a bond T3a OH
3152 CMe S QIj a bond Me a bond NH 0 a bond T3b OH
3153 CMe S QIj a bond Me a bond NH 0 a bond T3c OH
3154 CMe S QIj a bond Me a bond NH 0 a bond T3d OH
3155 CMe S QIj a bond Me a bond NH 0 a bond T3e OH
3156 CMe S QIj a bond Me a bond NH 0 a bond T3f OH
3157 CMe S QIj a bond Me a bond NH 0 a bond T3g OH
3158 CMe S QIj a bond Me a bond NH 0 a bond T3h OH
3159 CMe S QIj a bond Me a bond NH 0 a bond T3i OH
3160 CMe S QIj a bond Me a bond NH 0 a bond T3j OH
3161 CMe S QIj a bond H a bond NH S NH T3a OH
3162 CMe S Qij a bond H a bond NH S NH T3b OH
3163 CMe S QIj a bond H a bond NH S NH T3c OH
3164 CMe S Qij a bond H a bond NH S NH T3d OH
3165 CMe S Qij a bond H a bond NH S NH T3e OH
3166 CMe S Qij a bond H a bond NH S NH T3f OH
3167 CMe S Qij a bond H a bond NH S NH T3g OH
3168 CMe S Qij a bond H a bond NH S NH T3h OH
3169 CMe S QIj a bond H a bond NH S NH T3i OH
3170 CMe S Qij a bond H a bond NH S NH T3j OH
3171 CMe S Qij a bond H a bond NH S a bond T3a OH
3172 CMe S Qij a bond H a bond NH S a bond T3b OH
3173 CMe S Qij a bond H a bond NH S a bond T3c OH
3174 CMe S Qij a bond H a bond NH S a bond T3d OH
3175 CMe S Qij a bond H a bond NH S a bond T3e OH
3176 CMe S Qij a bond H a bond NH S a bond T3f OH
3177 CMe S Qij a bond H a bond NH S a bond T3g OH
3178 CMe S Qij a bond H a bond NH S a bond T3h OH
3179 CMe S Qij a bond H a bond NH S a bond T3i OH
3180 CMe S Qij a bond H a bond NH S a bond T3j OH
3181 CMe S Qij a bond H a bond NH 0 NH T3a OH
3182 CMe S Qij a bond H a bond NH 0 NH T3b OH 3183 CMe S QIj a bond H a bond NH 0 NH T3c OH
3184 CMe S Qij a bond H a bond NH 0 NH T3d OH
3185 CMe S QIj a bond H a bond NH 0 NH T3e OH
3186 CMe S Qij a bond H a bond NH 0 NH T3f OH
3187 CMe S QIj a bond H a bond NH 0 NH T3g OH
3188 CMe S QIj a bond H a bond NH 0 NH T3h OH
3189 CMe S Qij a bond H a bond NH 0 NH T3i OH
3190 CMe S QIj a bond H a bond NH 0 NH T3j OH
3191 CMe S QIj a bond H a bond NH 0 a bond T3a OH
3192 CMe S QIj a bond H a bond NH 0 a bond T3b OH
3193 CMe S QIj a bond H a bond NH 0 a bond T3c OH
3194 CMe S QIj a bond H a bond NH 0 a bond T3d OH
3195 CMe S QIj a bond H a bond NH 0 a bond T3e OH
3196 CMe S QIj a bond H a bond NH 0 a bond T3f OH
3197 CMe S QIj a bond H a bond NH 0 a bond T3g OH
3198 CMe S QIj a bond H a bond NH 0 a bond T3h OH
3199 CMe S Qij a bond H a bond NH 0 a bond T3i OH
3200 CMe S Qij a bond H a bond NH 0 a bond T3j OH
3201 CMe 0 QIa a bond Me a bond NH S NH T3a OH 3202 CMe 0 QIa a bond Me a bond NH S NH T3b OH
3203 CMe 0 QIa a bond Me a bond NH S NH T3c OH
3204 CMe 0 QIa a bond Me a bond NH S NH T3d OH
3205 CMe 0 QIa a bond Me a bond NH S NH T3e OH
3206 CMe 0 QIa a bond Me a bond NH S NH T3f OH 3207 CMe 0 QIa a bond Me a bond NH S NH T3g OH
3208 CMe 0 QIa a bond Me a bond NH S NH T3h OH
3209 CMe 0 QIa a bond Me a bond NH S NH T3i OH
3210 CMe 0 QIa a bond Me a bond NH S NH T3j OH
3211 CMe 0 QIa a bond Me a bond NH S a bond T3a OH 3212 CMe 0 QIa a bond Me a bond NH S a bond T3b OH
3213 CMe 0 QIa a bond Me a bond NH S a bond T3c OH
3214 CMe 0 QIa a bond Me a bond NH S a bond T3d OH
3215 CMe 0 QIa a bond Me a bond NH S a bond T3e OH
3216 CMe 0 QIa a bond Me a bond NH S a bond T3f OH 3217 CMe 0 QIa a bond Me a bond NH S a bond T3g OH
3218 CMe 0 QIa a bond Me a bond NH S a bond T3h OH 3219 CMe 0 QIa a bond Me a bond NH S a bond T3i OH
3220 CMe 0 QIa a bond Me a bond NH S a bond T3j OH
3221 CMe 0 QIa a bond Me a bond NH 0 NH T3a OH
3222 CMe 0 QIa a bond Me a bond NH 0 NH T3b OH 3223 CMe 0 QIa a bond Me a bond 'NH 0 NH T3c OH
3224 CMe 0 QIa a bond Me a bond NH 0 NH T3d OH
3225 CMe 0 QIa a bond Me a bond NH 0 NH T3e OH
3226 CMe 0 QIa a bond Me a bond NH 0 NH T3f OH
3227 CMe 0 QIa a bond Me a bond NH 0 NH T3g OH 3228 CMe 0 QIa a bond Me a bond NH 0 NH T3h OH
3229 CMe 0 QIa a bond Me a bond NH 0 NH T3i OH
3230 CMe 0 QIa a bond Me a bond NH 0 NH T3j OH
3231 CMe 0 QIa a bond Me a bond NH 0 a bond T3a OH
3232 CMe 0 QIa a bond Me a bond NH 0 a bond T3b OH 3233 CMe 0 QIa a bond Me a bond NH 0 a bond T3c OH
3234 CMe 0 QIa a bond Me a bond NH 0 a bond T3d OH
3235 CMe 0 QIa a bond Me a bond NH 0 a bond T3e OH
3236 CMe 0 QIa a bond Me a bond NH 0 a bond T3f OH
3237 CMe 0 QIa a bond Me a bond NH 0 a bond T3g OH 3238 CMe 0 QIa a bond Me a bond NH 0 a bond T3h OH
3239 CMe 0 QIa a bond Me a bond NH 0 a bond T3i OH
3240 CMe 0 QIa a bond Me a bond NH 0 a bond T3j OH
3241 CMe 0 QIa a bond H a bond NH S NH T3a OH
3242 CMe 0 QIa a bond H a bond NH S NH T3b OH 3243 CMe 0 QIa a bond H a bond NH S NH T3c OH
3244 CMe 0 QIa a bond H a bond NH S NH T3d OH
3245 CMe 0 QIa a bond H a bond NH S NH T3e OH
3246 CMe 0 QIa a bond H a bond NH S NH T3f OH
3247 CMe 0 QIa a bond H a bond NH S NH T3g OH 3248 CMe 0 QIa a bond H a bond NH S NH T3h OH
3249 CMe 0 QIa a bond H a bond NH S NH T3i OH
3250 CMe 0 QIa a bond H a bond NH S NH T3j OH
3251 CMe 0 QIa a bond H a bond NH S a bond T3a OH
3252 CMe 0 QIa a bond H a bond NH S a bond T3b OH 3253 CMe 0 QIa a bond H a bond NH S a bond T3c OH
3254 CMe 0 QIa a bond H a bond NH S a bond T3d OH 3255 CMe 0 QIa a bond H a bond NH S a bond T3e OH
3256 CMe 0 QIa a bond H a bond NH S a bond T3f OH
3257 CMe 0 QIa a bond H a bond NH S a bond T3g OH
3258 CMe 0 QIa a bond H a bond NH S a bond T3h OH 3259 ' CMe 0 QIa a bond H a bond NH S a bond T3i OH
3260 CMe 0 QIa a bond H a bond NH S a bond T3j OH
3261 CMe 0 QIa a bond H a bond NH 0 NH T3a OH
3262 CMe 0 QIa a bond H a bond NH 0 NH T3b OH
3263 CMe 0 QIa a bond H a bond NH 0 NH T3c OH 3264 CMe 0 QIa a bond H a bond NH 0 NH T3d OH
3265 CMe 0 QIa a bond H a bond NH 0 NH T3e OH
3266 CMe 0 QIa a bond H a bond NH 0 NH T3f OH
3267 CMe 0 QIa a bond H a bond NH 0 NH T3g OH
3268 CMe 0 QIa a bond H a bond NH 0 NH T3h OH 3269 CMe 0 QIa a bond H a bond NH 0 NH T3i OH
3270 CMe 0 QIa a bond H a bond NH 0 NH T3j OH
3271 CMe 0 QIa a bond H a bond NH 0 a bond T3a OH
3272 CMe 0 QIa a bond H a bond NH 0 a bond T3b OH
3273 CMe 0 QIa a bond H a bond NH 0 a bond T3c OH 3274 CMe 0 QIa a bond H a bond NH 0 a bond T3d OH
3275 CMe 0 QIa a bond H a bond NH 0 a bond T3e OH
3276 CMe 0 QIa a bond H a bond NH 0 a bond T3f OH
3277 CMe 0 QIa a bond H a bond NH 0 a bond T3g OH
3278 CMe 0 QIa a bond H a bond NH 0 a bond T3h OH 3279 CMe 0 QIa a bond H a bond NH 0 a bond T3i OH
3280 CMe 0 QIa a bond H a bond NH 0 a bond T3j • OH
3281 CMe 0 QIb a bond Me a bond NH S NH T3a OH
3282 CMe 0 QIb a bond Me a bond NH S NH T3b OH
3283 CMe 0 QIb a bond Me a bond NH S NH T3c OH 3284 CMe 0 QIb a bond Me a bond NH S NH T3d OH
3285 CMe 0 QIb a bond Me a bond NH S NH T3e OH
3286 CMe 0 QIb a bond Me a bond NH S NH T3f OH
3287 CMe 0 QIb a bond Me a bond NH S NH T3g OH
3288 CMe 0 QIb a bond Me a bond NH S NH T3h OH 3289 CMe 0 QIb a bond Me a bond NH S NH T3i OH
3290 CMe 0 QIb a bond Me a bond NH S NH T3j OH 3291 CMe 0 QIb a bond Me a bond NH S a bond T3a OH
3292 CMe 0 QIb a bond Me a bond NH S a bond T3b OH
3293 CMe 0 QIb a bond Me a bond NH S a bond T3c OH
3294 CMe 0 QIb a bond Me a bond NH S a bond T3d OH 3295 CMe 0 QIb a bond Me a bond ' NH S a bond T3e OH
3296 CMe 0 QIb a bond Me a bond NH S a bond T3f OH
3297 CMe 0 QIb a bond Me a bond NH S a bond T3g OH
3298 CMe 0 QIb a bond Me a bond NH S a bond T3h OH
3299 CMe 0 QIb a bond Me a bond NH S a bond T3i OH 3300 CMe 0 QIb a bond Me a bond NH S a bond T3j OH
3301 CMe 0 QIb a bond Me a bond NH 0 NH T3a OH
3302 CMe 0 QIb a bond Me a bond NH 0 NH T3b OH
3303 CMe 0 QIb a bond Me a bond NH 0 NH T3c OH
3304 CMe 0 QIb a bond Me a bond NH 0 NH T3d OH
3305 CMe 0 QIb a bond Me a bond NH 0 NH T3e OH
3306 CMe 0 QIb a bond Me a bond NH 0 NH T3f OH
3307 CMe 0 QIb a bond Me a bond NH 0 NH T3g OH
3308 CMe 0 QIb a bond Me a bond NH 0 NH T3h OH
3309 CMe 0 QIb a bond Me a bond NH 0 NH T3i OH
3310 CMe 0 QIb a bond Me a bond NH 0 NH T3j OH
3311 CMe 0 QIb a bond Me a bond NH 0 a bond T3a OH
3312 CMe 0 QIb a bond Me a bond NH 0 a bond T3b OH
3313 CMe 0 QIb a bond Me a bond NH 0 a bond T3c OH
3314 CMe 0 QIb a bond Me a bond NH 0 a bond T3d OH
3315 CMe 0 QIb a bond Me a bond NH 0 a bond T3e OH
3316 CMe 0 QIb a bond Me a bond NH 0 a bond T3f OH
3317 CMe 0 QIb a bond Me a bond NH 0 a bond T3g OH
3318 CMe 0 QIb a bond Me a bond NH 0 a bond T3h OH
3319 CMe 0 QIb a bond Me a bond NH 0 a bond T3i OH
3320 CMe 0 QIb a bond Me a bond NH 0 a bond T3j OH
3321 CMe 0 QIb a bond H a bond Ml S NH T3a OH
3322 CMe 0 QIb a bond H a bond NH S NH T3b OH
3323 CMe 0 QIb a bond H a bond NH S NH T3c OH
3324 CMe 0 QIb a bond H a bond NH S NH T3d OH
3325 CMe 0 QIb a bond H a bond NH S NH T3e OH
3326 CMe 0 QIb a bond H a bond NH S NH T3f OH 3327 CMe 0 QIb a bond H a bond NH S NH T3g OH
3328 CMe 0 QIb a bond H a bond NH S NH T3h OH
3329 CMe 0 QIb a bond H a bond NH S NH T3i OH
3330 CMe 0 QIb a bond H a bond NH S NH T3j OH 3331 CMe 0 QIb a bond H a bond NH S a bond T3a OH
3332 CMe 0 QIb a bond H a bond NH S a bond T3b OH
3333 CMe 0 QIb a bond H a bond NH S a bond T3c OH
3334 CMe 0 QIb a bond H a bond NH S a bond T3d OH
3335 CMe 0 QIb a bond H a bond NH S a bond T3e OH 3336 CMe 0 QIb a bond H a bond NH S a bond T3f OH
3337 CMe 0 QIb a bond H a bond NH S a bond T3g OH
3338 CMe 0 QIb a bond H a bond NH S a bond T3h OH
3339 CMe 0 QIb a bond H a bond NH S a bond T3i OH
3340 CMe 0 QIb a bond H a bond NH S a bond T3j OH 3341 CMe 0 QIb a bond H a bond NH 0 NH T3a OH
3342 CMe 0 QIb a bond H a bond NH 0 NH T3b OH
3343 CMe 0 QIb a bond H a bond NH 0 NH T3c OH
3344 CMe 0 QIb a bond H a bond NH 0 NH T3d OH
3345 CMe 0 QIb a bond H a bond NH 0 NH T3e OH 3346 CMe 0 QIb a bond H a. bond NH 0 NH T3f OH
3347 CMe 0 QIb a bond H a bond NH 0 NH T3g OH
3348 CMe. 0 QIb a bond H a bond NH 0 NH T3h OH
3349 CMe 0 QIb a bond H a bond NH 0 NH T3i OH
3350 CMe 0 QIb a bond H a bond NH 0 NH T3j OH 3351 CMe 0 QIb a bond H a bond NH 0 a bond T3a OH
3352 CMe 0 QIb a bond H .a bond NH 0 a bond T3b OH
3353 CMe 0 QIb a bond H a bond NH 0 a bond T3c OH
3354 CMe 0 QIb a bond H a bond NH 0 a bond T3d OH
3355 CMe 0 QIb a bond H a bond NH 0 a bond T3e OH 3356 CMe 0 QIb a bond H a bond NH 0 a bond T3f OH
3357 CMe 0 QIb a bond H ' a bond NH 0 a bond T3g OH
3358 CMe 0 QIb a bond H a bond NH 0 a bond T3h OH
3359 CMe 0 QIb a bond H a bond NH 0 a bond T3i OH
3360 CMe 0 QIb a bond H a bond NH 0 a bond T3j OH 3361 CMe 0 QIc a bond Me a bond NH S NH T3a OH
3362 CMe 0 QIc a bond Me a bond NH S NH T3b ' OH 3363 CMe 0 QIc a bond Me a bond NH S NH T3c OH
3364 CMe 0 QIc a bond Me a bond NH S NH T3d OH
3365 CMe 0 QIc a bond Me a bond NH S NH T3e OH
3366 CMe 0 QIc a bond Me a bond NH S NH T3f OH 3367 CMe 0 QIc a bond Me a bond 'NH S NH T3g OH
3368 CMe 0 QIc a bond Me a bond NH S NH T3h OH
3369 CMe 0 QIc a bond Me a bond NH S NH T3i OH
3370 CMe 0 QIc a bond Me a bond NH S NH T3j OH
3371 CMe 0 QIc a bond Me a bond NH S a bond T3a OH 3372 CMe 0 QIc a bond Me a bond NH S a bond T3b OH
3373 CMe 0 QIc a bond Me a bond NH S a bond T3c OH
3374 CMe 0 QIc a bond Me a bond NH S a bond T3d OH
3375 CMe 0 QIc a bond Me a bond NH S a bond T3e OH
3376 CMe 0 QIc a bond Me a bond NH S a bond T3f OH 3377 CMe 0 QIc a bond Me a bond NH S a bond T3g OH
3378 CMe 0 QIc a bond Me a bond NH S a bond T3h OH
3379 CMe 0 QIc a bond Me a bond NH S a bond T3i OH
3380 CMe 0 QIc a bond Me a bond NH S a bond T3j OH
3381 CMe 0 QIc a bond Me a bond NH 0 NH T3a OH 3382 CMe 0 QIc a bond Me a bond NH 0 NH T3b OH
3383 CMe 0 QIc a bond Me a bond NH 0 NH T3c OH
3384 CMe 0 QIc a bond Me a bond NH 0 NH T3d OH
3385 CMe 0 QIc a bond Me a bond NH 0 NH T3e OH
3386 CMe 0 QIc a bond Me a bond NH 0 NH T3f OH 3387 CMe 0 QIc a bond Me a bond NH 0 NH T3g OH
3388 CMe 0 QIc a bond Me a bond NH 0 NH T3h OH
3389 CMe 0 QIc a bond Me a bond NH 0 NH T3i OH
3390 CMe 0 QIc a bond Me a bond NH 0 NH T3j OH
3391 CMe 0 QIc a bond Me a bond NH 0 a bond T3a OH 3392 CMe 0 QIc a bond Me a bond NH 0 a bond T3b OH
3393 CMe 0 QIc a bond Me a bond NH 0 a bond T3c OH
3394 CMe 0 QIc a bond Me a bond NH 0 a bond T3d OH
3395 CMe 0 QIc a bond Me a bond NH 0 a bond T3e OH
3396 CMe 0 QIc a bond Me a bond NH 0 a bond T3f OH 3397 CMe 0 QIc a bond Me a bond NH 0 a bond T3g OH
3398 CMe 0 QIc a bond Me a bond NH 0 a bond T3h OH 3399 CMe 0 QIc a bond Me a bond NH 0 a bond T3i OH
3400 CMe 0 QIc a bond Me a bond NH 0 a bond T3j OH
3401 CMe 0 QIc a bond H a bond NH S NH T3a OH
3402 CMe 0 QIc a bond H a bond NH S NH T3b OH 3403 CMe 0 QIc a bond H a bond 'NH S NH T3c OH
3404 CMe 0 QIc a bond H a bond NH S NH T3d OH
3405 CMe 0 QIc a bond H a bond NH S NH T3e OH
3406 CMe 0 QIc a bond H a bond NH S NH T3f OH
3407 CMe 0 QIc a bond H a bond NH S NH T3g OH 3408 CMe 0 QIc a bond H a bond NH S NH T3h OH
3409 CMe 0 QIc a bond H a bond NH S NH T3i OH
3410 CMe 0 QIc a bond H a bond NH S NH T3j OH
3411 CMe 0 QIc a bond H a bond NH S a bond T3a OH
3412 CMe 0 QIc a bond H a bond NH S a bond T3b OH 3413 CMe 0 QIc a bond H a bond NH S a bond T3c OH
3414 CMe 0 QIc a bond H a bond NH S a bond T3d OH
3415 CMe 0 QIc a bond H a bond NH S a bond T3e OH
3416 CMe 0 QIc a bond H a bond NH S a bond T3f OH
3417 CMe 0 QIc a bond H a bond NH S a bond T3g OH 3418 CMe 0 QIc a bond H a bond NH S a bond T3h OH
3419 CMe 0 QIc a bond H a bond NH S a bond T3i OH
3420 CMe 0 QIc a bond H a bond NH S a bond T3j OH
3421 CMe 0 QIc a bond H a bond NH 0 NH T3a OH
3422 CMe 0 QIc a bond H a bond NH 0 NH T3b OH 3423 CMe 0 QIc a bond H a bond NH 0 NH T3c OH
3424 CMe 0 QIc a bond H a bond NH 0 NH T3d OH
3425 CMe 0 QIc a bond H a bond NH 0 NH T3e OH
3426 CMe 0 QIc a bond H a bond NH 0 NH T3f OH
3427 CMe 0 QIc a bond H a bond NH 0 NH T3g OH 3428 CMe 0 QIc a bond H a bond NH 0 NH T3h OH
3429 CMe 0 QIc a bond H a bond NH 0 NH T3i OH
3430 CMe 0 QIc a bond H a bond NH 0 NH T3j OH
3431 CMe 0 QIc a bond H a bond NH 0 a bond T3a OH
3432 CMe 0 QIc a bond H a bond NH 0 a bond T3b OH 3433 CMe 0 QIc a bond H a bond NH 0 a bond T3c OH
3434 CMe 0 QIc a bond H a bond NH 0 a bond T3d OH 3435 CMe 0 QIc a bond H a bond NH 0 a bond T3e OH
3436 CMe 0 QIc a bond H a bond NH 0 a bond T3f OH
3437 CMe 0 QIc a bond H a bond NH 0 a bond T3g OH
3438 CMe 0 QIc a bond H a bond NH 0 a bond T3h OH
3439 CMe 0 QIc a bond H a bond NH 0 a bond T3i OH
3440 CMe 0 QIc a bond H a bond NH 0 a bond T3j OH
3441 CMe 0 QIi a bond Me a bond NH S NH T3a OH
3442 CMe 0 QIi a bond Me a bond NH S NH T3b OH
3443 CMe 0 QIi a bond Me a bond NH S NH T3c OH
3444 CMe 0 QIi a bond Me a bond NH S NH T3d OH
3445 CMe 0 QIi a bond Me a bond NH S NH T3e OH
3446 CMe 0 QIi a bond Me a bond NH S NH T3f OH
3447 CMe 0 QIi a bond Me a bond NH S NH T3g OH
3448 CMe 0 QIi a bond Me a bond NH S NH T3h OH
3449 CMe 0 QIi a bond Me a bond NH S NH T3i OH
3450 CMe 0 QIi a bond Me a bond NH S NH T3j OH
3451 CMe 0 QIi a bond Me a bond NH .S a bond T3a OH
3452 CMe 0 QIi a bond Me a bond NH S a bond T3b OH
3453 CMe 0 QIi a bond Me a bond NH S a bond T3c OH
3454 CMe 0 QIi a bond Me a bond NH S a bond T3d OH
3455 CMe 0 QIi a bond Me a bond NH S a bond T3e OH
3456 CMe 0 QIi a bond Me a bond NH S a bond T3f OH
3457 CMe 0 QIi a bond Me a bond NH S a bond T3g OH
3458 CMe 0 QIi a bond Me a bond NH S a bond T3h OH
3459 CMe 0 QIi a bond Me a bond NH S a bond T3i OH
3460 CMe 0 QIi a bond Me a bond NH S a bond T3j OH
3461 CMe 0 QIi a bond Me a bond NH 0 NH T3a OH
3462 CMe 0 QIi a bond Me a bond NH 0 NH T3b OH
3463 CMe 0 QIi a' bond Me a bond .NH 0 NH T3c OH
3464 CMe 0 QIi a bond Me a bond NH 0 NH T3d OH
3465 CMe 0 QIi a bond Me a bond NH 0 NH T3e OH
3466 CMe 0 QIi a bond Me a bond NH 0 NH T3f OH
3467 CMe 0 QIi a bond Me a bond NH 0 NH T3g OH
3468 CMe 0 QIi a bond Me a bond NH 0 NH T3h OH
3469 CMe 0 QIi a bond Me a bond NH 0 NH T3i OH
3470 CMe 0 QIi a bond Me a bond NH 0 NH T3j OH 3471 CMe 0 QIi a bond Me a bond NH 0 a bond T3a OH
3472 CMe 0 QIi a bond Me a bond NH 0 a bond T3b OH
3473 CMe 0 QIi a bond Me a bond NH 0 a bond T3c OH
3474 CMe 0 QIi a bond Me a bond NH 0 a bond T3d OH
3475 CMe 0 QIi a bond Me a bond NH 0 a bond T3e OH
3476 CMe 0 QIi a bond Me a bond NH 0 a bond T3f OH
3477 CMe 0 QIi a bond Me a bond NH 0 a bond T3g OH
3478 CMe 0 QIi a bond Me a bond NH 0 a bond T3h OH
3479 CMe 0 QIi a bond Me a bond NH 0 a bond T3i OH
3480 CMe 0 QIi a bond Me a bond NH 0 a bond T3j OH
3481 CMe 0 QIi a bond H a bond NH S NH T3a OH
3482 CMe 0 QIi a bond H a bond NH S NH T3b OH
3483 CMe 0 QIi a bond H a bond NH S NH T3c OH
3484 CMe 0 QIi a bond H a bond NH S NH T3d OH
3485 CMe 0 QIi a bond H a bond NH S NH T3e OH
3486 CMe 0 QIi a bond H a bond NH S NH T3f OH
3487 CMe 0 QIi a bond H a bond NH S NH T3g OH
3488 CMe 0 QIi a bond H a bond NH S NH T3h OH
3489 CMe 0 QIi a bond H a bond NH S NH T3i OH
3490 CMe 0 QIi a bond H a bond NH S NH T3j OH
3491 CMe 0 QIi a bond H a bond NH S a bond T3a OH
3492 CMe 0 QIi a bond H a bond NH. S a bond T3b OH
3493 CMe 0 QIi a bond- H a bond 'NH S a bond T3c OH
3494 CMe 0 QIi a bond H a bond NH S a bond T3d OH
3495 CMe 0 QIi a bond H a bond NH S a bond T3e OH
3496 CMe 0 QIi a bond H a bond NH S a bond T3f OH
3497 CMe 0 QIi a bond H a bond NH S a bond T3g OH
3498 CMe 0 QIi a bond H a bond NH S a bond T3h OH
3499 CMe 0 QIi a bond H a bond NH S a bond T3i OH
3500 CMe 0 QIi a bond H a bond NH S a bond T3j OH
3501 CMe 0 QIi a bond H a bond NH 0 NH T3a OH
3502 CMe 0 QIi a bond H a bond NH 0 NH T3b OH
3503 CMe 0 QIi a bond H a bond NH 0 NH T3c OH
3504 CMe 0 QIi a bond H a bond NH 0 NH T3d OH
3505 CMe 0 QIi a bond H a bond NH 0 NH T3e OH
3506 CMe 0 QIi a bond H a bond NH 0 NH T3f OH 3507 CMe 0 QIi a bond H a bond NH 0 NH T3g OH
3508 CMe 0 QIi a bond H a bond NH 0 NH T3h OH
3509 CMe 0 QIi a bond H a bond NH 0 NH T3i OH
3510 CMe 0 QIi a bond H a bond NH 0 NH T3j OH 3511 CMe 0 QIi a bond H a bond NH 0 a bond T3a OH
3512 CMe 0 QIi a bond H a bond NH 0 a bond T3b OH
3513 CMe 0 QIi a bond H a bond NH 0 a bond T3c OH
3514 CMe 0 QIi a bond H a bond NH 0 a bond T3d OH
3515 CMe 0 QIi a bond H a bond NH 0 a bond T3e OH 3516 CMe 0 QIi a bond H a bond NH 0 a bond T3f OH
3517 CMe 0 QIi a bond H a bond NH 0 a bond T3g OH
3518 CMe 0 QIi a bond H a bond NH 0 a bond T3h OH
3519 CMe 0 QIi a bond H a bond NH 0 a bond T3i OH
3520 CMe 0 QIi a bond H a bond NH 0 a bond T3j OH 3521 CMe 0 QIj a bond Me a bond NH S NH T3a OH
3522 CMe 0 QIj a bond Me a bond NH S NH T3b OH
3523 CMe 0 QIj a bond Me a bond NH S NH T3c OH
3524 CMe 0 QIj a bond Me a bond NH S NH T3d OH
3525 CMe 0 QIj a bond Me a bond NH S NH T3e OH 3526 CMe 0 QIj a bond Me a bond NH S NH T3f OH
3527 CMe 0 QIj a bond Me a bond NH S NH T3g OH
3528 CMe 0 QIj a bond Me a bond NH S NH T3h OH
3529 CMe 0 QIj a bond Me a bond NH S NH T3i OH
3530 CMe 0 QIj a bond Me a bond NH S NH T3j OH 3531 CMe 0 QIj a bond 'Me a bond NH S a bond T3a OH
3532 CMe 0 QIj a bond Me a bond NH S a bond T3b OH
3533 CMe 0 QIj a bond Me a bond NH S a bond T3c OH
3534 CMe 0 QIj a bond Me a bond NH S a bond T3d OH
3535 CMe 0 QIj a bond Me a bond NH S a bond T3e OH 3536 CMe 0 QIj a bond Me a bond NH S a bond T3f OH
3537 CMe 0 QIj a bond Me a bond NH S a bond T3g OH
3538 CMe 0 QIj a bond Me a bond NH S a bond T3h OH
3539 CMe 0 QIj a bond Me a bond NH S a bond T3i OH
3540 CMe 0 QIj a bond Me a bond NH S a bond T3j OH 3541 CMe 0 QIj a bond Me a bond NH 0 NH T3a OH
3542 CMe 0 QIj a bond Me a bond NH 0 NH T3b OH 3543 CMe 0 QIj a bond Me a bond NH 0 NlI T3c OH
3544 CMe 0 QIj a bond Me a bond NH 0 M \ T3d OH
3545 CMe 0 QIj a bond Me a bond NH 0 NH T3e OH
3546 CMe 0 QIj a bond Me a bond NH 0 NH T3f OH
3547' CMe 0 QIj a bond Me a bond "NH 0 NH T3g OH
3548 CMe 0 QIj a bond Me a bond NH 0 NI { T3h OH
3549 CMe 0 QIj a bond Me a bond NH 0 M I T3i OH
3550 CMe 0 QIj a bond Me a bond NH 0 NH T3j OH
3551 CMe 0 QIj a bond Me a bond NH 0 a bond T3a OH
3552 CMe 0 QIj a bond Me a bond NH 0 a bond T3b OH
3553 CMe 0 QIj a bond Me a bond NH 0 a bond T3c OH
3554 CMe 0 QIj a bond Me a bond NH 0 a bond T3d OH
3555 CMe 0 QIj a bond Me a bond NH 0 a bond T3e OH
3556 CMe 0 QIj a bond Me a bond NH 0 a bond T3f OH
3557 CMe 0 QIj a bond Me a bond NH 0 a bond T3g OH
3558 CMe 0 Qij a bond Me a bond NH 0 a bond T3h OH
3559 CMe 0 QIj a bond Me a bond NH 0 a bond T3i OH
3560 CMe 0 Qij a bond Me a bond NH 0 a bond T3j OH
3561 CMe 0 Qij a bond H a bond NH S NH T3a OH
3562 CMe 0 Qij a bond H a bond NH S NH T3b OH
3563 CMe 0 Qij a bond H a bond NH S NH T3c OH
3564 CMe 0 Qij a bond H a bond NH S NH T3d OH
3565 CMe 0 Qij a .bond H a bond NH S NH T3e OH
3566 CMe 0 Qij a bond H a bond NH S NH T3f OH
3567 CMe 0 Qij a bond H a bond NH S NH T3g OH
3568 CMe 0 Qij a bond H a bond NH S NH T3h OH
3569 CMe 0 Qij a bond H a bond NH S NH T3i OH
3570 CMe 0 Qij a bond H a bond NH S NH T3j OH
3571 CMe 0 Qij a bond H a bond NH S a bond T3a OH
3572 CMe 0 Qij a bond H a bond NH S a bond T3b OH
3573 CMe 0. Qij a bond H a bond NH S a bond T3c OH'
3574 CMe 0 Qij a bond H a bond NH S a bond T3d OH
3575 CMe 0 Qij a bond H a bond NH S a bond T3e OH
3576 CMe 0 Qij a bond H a bond NH S a bond T3f OH
3577 CMe 0 Qij a bond H a bond NH S a bond T3g OH
3578 CMe 0 Qij a bond H a bond NH S a bond T3h OH 3579 CMe 0 QIj a bond H a bond NH S a bond T3i OH
3580 CMe 0 QIj a bond H a bond NH S a bond T3j OH
3581 CMe 0 QIj a bond H a bond NH 0 NH T3a OH 3582 CMe 0 QIj a bond H a bond NH 0 NH T3b OH 3583 CMe 0 QIj a bond H a bond NH 0 NH T3c OH
3584 CMe 0 QIj a bond H a bond NH 0 NH T3d OH
3585 CMe 0 QIj a bond H a bond NH 0 NH T3e OH
3586 CMe 0 QIj a bond H a bond NH 0 NH T3f OH
3587 CMe 0 QIj a bond H a bond NH 0 NH T3g OH 3588 CMe 0 QIj a • bond H a bond NH 0 NH T3h OH
3589 CMe 0 QIj a bond H a bond NH 0 NH T3i OH
3590 CMe 0 QIj a bond H a bond NH 0 NH T3j OH
3591 CMe 0 QIj a bond H a bond NH 0 a bond T3a OH
3592 CMe 0 QIj a bond H a bond NH 0 a bond T3b OH 3593 CMe 0 QIj a bond H a bond NH 0 a bond T3c OH
3594 CMe 0 QIj a bond H a bond NH 0 a bond T3d OH
3595 CMe 0 QIj a bond H a bond NH 0 a bond T3e OH
3596 CMe 0 QIj a bond H a bond NH 0 a bond T3f OH
3597 CMe 0 QIj a bond H a bond NH 0 a bond T3g OH 3598 CMe 0 QIj a bond H a bond NH 0 a bond T3h OH
3599 CMe 0 QIj a bond H a bond NH 0 a bond T3i OH
3600 CMe 0 QIj a bond H a bond NH 0 a bond T3j OH
3601 N NMe QIi a bond Me a bond NH S Nl 1 Q3e OH
3602 N NMe QIi a bond Me a bond NH S a bond Q3e OH 3603 N NMe QIi a bond Me a bond NH 0 NH Q3e OH
3604 N NMe QIi a bond Me a bond NH 0 a bond Q3e OH
3605 N NMe QIi a bond H a bond NH S NH Q3e OH
3606 N NMe QIi a bond H a bond NH S a bond Q3e OH
3607 N NMe QIi a bond H a bond NH 0 NH Q3e OH 3608 N NMe QIi a bond H a bond NH 0 a bond Q3e OH
3609 N NMe QIj a bond Me a bond NH S Nl 1 Q3e OH
3610 N NMe QIj a bond Me . a bond NH S a bond Q3e OH
3611 N NMe QIj a bond Me a bond NH 0 Nl 1 Q3e OH " 3612 N NMe QIj a bond Me a bond NH 0 a bond Q3e OH 3613 N NMe QIj a bond H a bond NH S NH Q3e OH
3614 N NMe QIj a bond H a bond NH S a bond Q3e OH 3615 N NMe QIj a bond H a bond NH 0 NH Q3e OH
3616 N NMe QIj a bond H a bond NH 0 a bond Q3e OH
3617 N S QIi a bond Me a bond NH S NH Q3e OH
3618 N S QIi a bond Me a bond NH S a bond Q3e OH 3619 N S QIi a bond Me a bond NH 0 NH Q3e OH
3620 N S QIi a bond Me a bond NH 0 a bond Q3e OH
3621 N S QIi a bond H a bond NH S NH Q3e OH
3622 N S QIi a bond H a bond NH S a bond Q3e OH
3623 N S QIi a bond H a bond NH 0 NH Q3e OH 3624 N S QIi a bond H a bond NH 0 a bond Q3e OH
3625 N S QIj a bond Me a bond NH S NH Q3e OH
3626 N S QIj a bond Me a bond NH S a bond Q3e OH
3627 N S QIj a bond Me a bond NH 0 NH Q3e OH
3628 N S QIj a bond Me a bond NH 0 a bond Q3e OH 3629 N S QIj a bond H a bond NH S NH Q3e OH
3630 N S QIj a bond H a bond NH S a bond Q3e OH
3631 N S QIj a bond H a bond NH 0 NH Q3e OH
3632 N S QIj a bond H a bond NH 0 a bond Q3e OH
3633 N 0 QIi a bond Me a bond NH S NH Q3e OH 3634 N 0 QIi a bond Me a bond NH S a bond Q3e OH
3635 N 0 QIi a bond Me a bond NH 0 NH Q3e OH
3636 N 0 QIi a- bond Me a bond NH 0 a bond Q3e OH
3637 N 0 QIi a bond H a bond NH S NH Q3e OH
3638 N 0 QIi a bond H a bond NH S a bond Q3e OH 3639 N 0 QIi a bond H a bond NH 0 NH Q3e OH
3640 N 0 QIi a bond H a bond NH 0 a bond Q3e OH
3641 N 0 QIj a bond Me a bond NH S NH Q3e OH
3642 N 0 QIj a bond Me a. bond NH S a bond Q3e. OH
3643 N 0 QIj a bond Me a bond NH 0 NH Q3e OH 3644 N 0 QIj a bond Me a bond NH 0 a bond Q3e OH
3645 N 0 QIj a bond H a bond NH S-NH Q3e OH
3646 N 0 QIj a bond H a bond NH S a bond Q3e OH
3647 N 0 QIj a bond H a bond NH 0 NH Q3e OH
3648 N 0 QIj a bond H a bond NH 0 a bond Q3e OH 3649 CH NMe QIi a bond Me a bond NH S NH Q3e OH
3650 CH NMe QIi a bond Me a bond NH S a bond Q3e OH 3651 CH NMe QIi a bond Me a bond NH 0 NH Q3e OH
3652 CH NMe QIi a bond Me a bond NH 0 a bond Q3e OH
3653 CH NMe QIi a bond H a bond NH S NH Q3e OH
3654 CH NMe QIi a bond H a bond NH S a bond Q3e OH
3655' CH NMe QIi a bond H a bond 'NH 0 NH Q3e OH
3656 CH NMe QIi a bond H a bond NH 0 a bond Q3e OH
3657 CH NMe QIj a bond Me a bond NH S NH Q3e OH
3658 CH NMe Qij a bond Me a bond NH S a bond Q3e OH
3659 CH NMe Qij a bond Me a bond NH 0 NH Q3e OH
3 3666600 C CHH N NMMee QQiIjj a bond Me a bond NH 0 a bond Q3e OH
3661 CH NMe QIj a bond H a bond NH S NH Q3e OH
3662 CH NMe QIj a bond H a bond NH S a bond Q3e OH
3663 CH NMe QIj a bond H a bond NH 0 NH Q3e OH
3664 CH NMe QIj a bond H a bond NH 0 a bond Q3e OH
3 3666655 C CHH S S Q QIIii a bond Me a bond NH S NH Q3e OH
3 3666666 C CHH S S Q QIIii a bond Me a bond NH S a bond Q3e OH
3 3666677 C CHH S S Q QIIii a bond Me a bond NH 0 NH Q3e OH
3 3666688 C CHH S S Q QIIii a bond Me a bond NH 0 a bond Q3e OH
3 3666699 C CHH S S Q QIIii a bond H a bond NH S NH Q3e OH
3 3667700 C CHH S S Q QIIii a bond H a bond NH S a bond Q3e OH
3 3667711 C CHH S S Q QIIii a bond H a bond NH 0 NH Q3e OH
3 3667722 C CHH S S Q QIIii a bond H a bond NH 0 a bond Q3e OH
3 3667733 C CHH S S Q QIIjj a bond Me a bond NH S NH Q3e OH
3 3667744 C CHH S S Q QIIjj a bond Me a bond NH S a bond Q3e OH
3 3667755 C CHH S S Q QIIjj a bond Me a bond NH 0 NH Q3e OH
3 3667766 C CHH S S Q QIIjj a bond Me a bond NH 0 a bond Q3e OH
3 3667777 C CHH S S Q QIIjj a bond H a bond NH S NH Q3e OH
3 3667788 C CHH S S Q QIIjj a bond H a bond NH S' a bond Q3e OH
3 3667799 C CHH S S Q QIIjj a bond H a bond NH 0 NH Q3e OH
3 3668800 C CHH S S Q QIIjj a bond H a bond NH 0 a bond Q3e OH
3681 CH 0 QIi a bond Me a bond NH S NH Q3e OH
3682 CH 0 QIi a bond Me a bond NH S a bond Q3e OH
3683 CH 0 QIi a bond Me a bond NH 0 NH Q3e OH
3684 CH 0 QIi a bond Me a bond NH 0 a bond Q3e OH
3685 CH 0 QIi a bond H a bond NH S NH Q3e OH
3686 CH 0 QIi a bond H a bond NH S a bond . Q3e OH 3687 CH 0 QIi a bond H a bond NH O NH Q3e OH
3688 CH O QIi a bond H a bond NH 0 a bond Q3e OH
3689 CH 0 QIj a bond Me a bond NH S NH Q3e OH
3690 CH 0 QIj a bond Me a bond NH S a bond Q3e OH 3691 ' CH 0 QIj a bond Me a bond NH 0 NH Q3e OH
3692 CH 0 QIj a bond Me a bond NH 0 a bond Q3e OH
3693 CH 0 QIj a bond H a bond NH S NH Q3e OH
3694 CH 0 QIj a bond H a bond NH S a bond Q3e OH
3695 CH 0 QIj a bond H a bond NH 0 NH Q3e OH 3696 CH 0 QIj a bond H a bond NH 0 a bond Q3e OH
3697 CMe NMe QIi a bond Me a bond NH S NH Q3e OH
3698 CMe NMe QIi a bond Me a bond NH S a bond Q3e OH
3699 CMe NMe QIi a bond Me a bond NH 0 NH Q3e OH
3700 CMe NMe QIi a bond Me a bond NH 0 a bond Q3e OH 3701 CMe NMe QIi a bond H a bond. NH S NH Q3e OH
3702 CMe NMe QIi a bond H a bond NH S a bond Q3e OH
3703 CMe NMe QIi a bond H a bond NH 0 NH Q3e OH
3704 CMe NM Ie QIi a bond H a bond NH 0 a bond Q3e OH
3705 CMe NMe QIj a bond Me a bond NH S NH Q3e OH 3 3770066 C CMMee N NMM Iee QQIIjj a bond Me a bond NH S a bond Q3e OH
3707 CMe NM Ie QIj a bond Me a bond NH 0 NH Q3e OH
3708 CMe NM Ie QIj a bond Me a bond NH 0 a bond Q3e OH
3709 CMe NMe QIj a bond H a bond NH S NH Q3e OH
3710 CMe Ni Ie QIj a bond H a bond NH S a bond Q3e OH 3 3771111 C CMMee N NMM Iee' QQIIjj a bond H a bond NH 0 NH Q3e OH
3712 CMe NM Ie QIj a bond H a bond NH 0 a bond Q3e OH
3713 CMe S QIi a bond Me a bond NH S NH Q3e OH
3714 CMe S QIi a bond Me a bond NH S a bond Q3e OH
3715 CMe S QIi a bond Me a bond NH 0 NH Q3e OH 3 3771166 C CMMee S S Q QIIii a bond Me a bond NH 0 a bond Q3e OH
3717 CMe S. QIi a bond H a bond NH S ' NH Q3e OH
3718 CMe S QIi a bond H a bond NH S a bond Q3e OH
3719 CMe S QIi a bond H a bond NH 0 NH Q3e OH
3720 CMe S QIi a bond H a bond NH 0 a bond Q3e OH 3 3772211 C CMMee S S Q QIIjj a bond Me a bond NH S NH Q3e OH
3722 CMe S QIj a bond Me a bond NH S a bond Q3e OH 3723 CMe S QIj a bond Me a bond NH 0 NH Q3e OH
3724 CMe S QIj a bond Me a bond NH 0 a bond Q3e OH
3725 CMe S QIj a bond H a bond NH S NH Q3e OH
3726 CMe S QIj a bond H a bond NH S a bond Q3e OH 3727 CMe S QIj a bond H a bond NH 0 NH Q3e OH
3728 CMe S QIj a bond H a bond NH 0 a bond Q3e OH
3729 CMe 0 QIi a bond Me a bond NH S NH Q3e OH
3730 CMe 0 QIi a bond Me a bond NH S a bond Q3e OH
3731 CMe 0 QIi a bond Me a bond NH 0 NH Q3e OH 3732 CMe 0 QIi a bond Me a bond NH 0 a bond Q3e OH
3733 CMe 0 QIi a bond H a bond NH S NH Q3e OH
3734 CMe 0 QIi a bond . H a bond NH S a bond Q3e OH
3735 CMe 0 QIi a bond H a bond NH 0 NH Q3e OH
3736 CMe 0 QIi a bond H a bond NH 0 a bond Q3e OH 3737 CMe 0 QIj a bond Me a bond NH S NH Q3e OH
3738 CMe 0 QIj a bond Me a bond NH S a bond Q3e OH
3739 CMe 0 QIj a bond Me a bond NH 0 NH Q3e OH
3740 CMe 0 QIj a bond Me a bond NH 0 a bond Q3e OH
3741 CMe 0 QIj a bond H a bond NH S NH Q3e OH 3742 CMe 0 QIj a bond H a bond NH S a bond Q3e OH
3743 CMe 0 QIj a bond H a bond NH 0 NH Q3e OH
3744 CMe 0 QIj a bond H a bond NH 0 a bond Q3e OH
61) The compounds' wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the- following combinations in Table 2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof- (provided that in the case of 61) , QIa, QIb, QIc, QIi, QIj, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 2 denote the following substituents) .
Figure imgf000519_0001
T3g = ^^CONEt2
Q1c = -Me T3c = ^CN
T3h =
Figure imgf000519_0002
T3i = XO2H
Figure imgf000519_0003
62) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 3, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof . The symbols in Table 3 denote the flowing substituents .
Figure imgf000519_0004
TABLE 3
No A B R1 L1 R2 V L3 Y L4 R3 X
1 N NMe QIa NH Me a bond Im S NH Q3a OH
2 N NMe QIa NH Me a bond I S a bond Q3a OH
3 N NMe QIa NH Me a bond I ^H 0 NH Q3a OH
4 N NMe QIa NH Me a bond I W 0 a bond Q3a OH
5 N NMe QIa NH H a bond NH S NH Q3a OH
6 N NMe QIa NH H a bond NH S a bond Q3a OH
7 N NMe QIa NH H a bond NH 0 NH Q3a OH
8 N NMe QIa NH H a bond NH 0 a bond Q3a OH
9 N NMe QIb NH Me a bond I S NH Q3a OH
10 N NMe QIb NH Me a bond NH S a bond Q3a OH
11 N NMe QIb NH Me a bond NH 0 NH Q3a OH
12 N NMe QIb NH Me a bond NH 0 a bond Q3a OH
13 N NMe QIb NH H a bond NH S NH Q3a OH
14 N NMe QIb NH H a bond NH S a bond Q3a OH
15 N NMe QIb NH H a bond NH 0 NH Q3a OH
16 N NMe QIb NH H a bond NH 0 a bond Q3a OH
17 N S QIa NH Me a bond NH S NH Q3a OH
18 N S QIa NH Me a bond NH S a bond Q3a OH
19 N S QIa NH Me a bond NH 0 NH Q3a OH
20 N S QIa NH Me a bond NH 0 a bond Q3a OH
21 N S QIa NH H a bond NH S NH Q3a OH
22 N S QIa NH H a bond NH S a bond Q3a OH
23 N S QIa NH H a bond NH 0 NH Q3a OH
24 N S QIa NH H a bond NH 0 a bond Q3a OH
25 N S QIb NH Me a bond NH S NH Q3a OH
26 N S QIb NH Me a bond NH S a bond Q3a OH
27 N S QIb NH Me a bond NH 0 NH Q3a OH
28 N S QIb NH Me a bond NH 0 a bond Q3a OH
29 N S QIb NH H a bond NH S NH Q3a OH
30 N S QIb NH H a bond NH S a bond Q3a OH
31 N S QIb NH H a bond NH 0 NH Q3a OH
32 N S QIb NH H a bond NH 0 a bond Q3a OH 33 N 0 QIa NH Me a bond NH S NH Q3a OH
34 N 0 QIa NH Me a bond NH S a bond Q3a OH
35 N 0 QIa NH Me a bond NH 0 NH Q3a OH
36 N 0 QIa NH Me a bond NH 0 a bond Q3a OH
37 N 0 QIa NH H a bond NH S NH Q3a OH
38 N 0 QIa NH H a bond NI { S a bond Q3a OH
39 N 0 QIa NH H a bond NI { 0 NH Q3a OH
40 N 0 QIa NH H a bond NI { 0 a bond Q3a OH
41 N 0 QIb NH Me a bond NH S NH Q3a OH
42 N 0 QIb NH Me a bond NH S a bond Q3a OH
43 N 0 QIb NH Me a bond NH 0 NH Q3a OH
44 N 0 QIb NH Me a bond NH 0 a bond Q3a OH
45 N 0 QIb NH H a bond NH S NH Q3a OH
46 N 0 QIb NH H a bond NI I S a bond Q3a OH
47 N 0 QIb NH H a bond NH 0 NH Q3a OH
48 N 0 QIb NH H a bond NIϊ 0 a bond Q3a OH
49 CH NMe QIa NH Me a bond NH S NH Q3a OH
50 CH NMe QIa NH Me a bond NH S a . bond Q3a OH
51 CH NMe QIa NH Me a bond NH 0 NH Q3a OH
52 CH NMe QIa NH Me a bond NH 0 a bond Q3a OH
53 CH NMe QIa NH H a bond NH S NH Q3a OH
54 CH NMe QIa NH H a bond NH S a bond Q3a OH
55 CH NMe QIa NH H a bond NH 0 NH Q3a OH
56 CH NMe QIa NH H a bond NH 0 a bond Q3a OH
57 CH NMe QIb NH Me a bond NH S NH Q3a OH
58 CH NMe QIb NH Me a bond NH S -a . bond Q3a OH
59 CH NMe QIb NH Me a bond NH 0 NH Q3a OH
60 CH NMe QIb NH Me a bond NH 0 a bond Q3a OH
61 CH NMe QIb NH H a bond NH S NH Q3a OH
62 CH NMe QIb NH H a bond NH S a bond Q3a OH
63 CH NMe QIb NH H a bond NH 0 NH Q3a OH
64 CH NMe QIb NH H a bond NH 0 a bond Q3a OH
65 CH S QIa NH Me a bond NH S NH Q3a OH
66 CH S QIa NH Me a bond NH S a bond Q3a OH
67 CH S QIa NH Me a bond NH 0 NH Q3a OH
68 CH S QIa NH Me a bond NH 0 a bond Q3a OH 69 CH S QIa NH H a bond NH S NH Q3a OH
70 CH S QIa NH H a bond NH S a bond Q3a OH
71 CH S QIa NH H a bond NH 0 NH Q3a OH
72 CH S QIa NH H a bond NH 0 a bond Q3a OH 73 CH S QIb NH Me a bond 'NH S NH Q3a OH
74 CH S QIb NH Me a bond NH S a bond Q3a OH
75 CH S QIb NH Me a bond NH 0 NH Q3a OH
76 CH S QIb NH Me a bond NH 0 a bond Q3a OH
77 CH S QIb NH H a bond NH S NH Q3a OH 78 CH S QIb NH H a bond NH S a bond Q3a OH
79 CH S QIb NH H a bond NH 0 NH Q3a OH
80 CH S QIb NH H a bond NH 0 a bond Q3a OH
81 CH 0 QIa NH Me a bond NH S NH Q3a OH
82 CH 0 QIa NH Me a bond NH S a bond Q3a OH 83 CH 0 QIa NH Me a bond NH 0 NH Q3a OH
84 CH 0 QIa NH Me a bond NH 0 a bond Q3a OH
85 CH 0 QIa NH H a bond NH S NH Q3a OH
86 CH 0 QIa NH H a bond NH S a bond Q3a OH
87 CH 0 QIa NH H a bond NH 0 NH Q3a OH 88 CH 0 QIa NH H a bond NH 0 a bond Q3a OH
89 CH 0 QIb NH Me a bond NH S NH Q3a OH
• 90 CH 0 QIb NH Me a bond NH S a bond Q3a OH
91 CH 0 QIb NH Me a bond NH 0 NH Q3a OH
92 CH 0 QIb NH Me a bond NH 0 a bond Q3a OH 93 CH 0 QIb NH H a bond NH S NH Q3a OH
94 CH 0 QIb NH H a bond NH S a bond Q3a OH
95 CH 0 QIb. NH H a bond NH 0 NH Q3a OH
96 CH 0 QIb NH H a bond NH 0 a bond Q3a OH
97 CMe NMe QIa NH Me a bond NH S NH Q3a OH 98 CMe NMe QIa NH Me a bond NH S a bond Q3a OH
.99 CMe NMe QIa NH Me a bond NH 0 NH Q3a OH
100 CMe NMe QIa NH Me a bond NH 0 a bond Q3a OH
101 CMe NMe QIa NH H a bond NH S NH Q3a OH
102 CMe NMe QIa NH H a bond NH S a bond Q3a OH 103 CMe NMe QIa NH H a bond NH 0 NH Q3a OH
104 CMe NMe QIa NH H a bond NH 0 a .bond Q3a OH 105 CMe NMe QIb NH Me a bond NH S NH Q3a OH
106 CMe NMe QIb NH Me a bond NH S a bond Q3a OH
107 CMe NMe QIb NH Me a bond NH 0 NH Q3a OH
108 CMe NMe QIb NH Me a bond NH 0 a bond Q3a OH
109 CMe NMe QIb NH H a bond NH S NH Q3a OH
110 CMe NMe QIb NH H a bond NH S a bond Q3a OH
111 CMe NMe QIb NH H a bond NH 0 NH Q3a OH
112 CMe NMe QIb NH H a bond NH 0 a bond Q3a OH
113 CMe S QIa NH Me a bond NH S NH Q3a OH
114 CMe S QIa NH Me a bond NH S a bond Q3a OH
115 CMe S QIa NH Me a bond NH 0 NH Q3a OH
116 CMe S QIa NH Me a bond NH 0 a bond Q3a OH
117 CMe S QIa NH H a bond NH S NH Q3a OH
118 CMe S QIa NH H a bond NH S a bond Q3a OH
119 CMe S QIa NH H a bond NH 0 NH Q3a OH
120 CMe S QIa NH H a bond NH 0 a bond Q3a OH
121 CMe S QIb NH Me a bond NH S NH Q3a OH
122 CMe S QIb NH Me a bond NH S a bond Q3a OH
123 CMe S QIb NH Me a bond NH 0 NH Q3a OH
124 CMe S QIb NH Me a bond NH 0 a bond Q3a OH
125 CMe S QIb NH H a bond NH S NH Q3a OH
126 CMe S QIb NH H a bond NH S a bond Q3a OH
127 CMe S QIb NH H a bond NH 0 NH Q3a OH
128 CMe S QIb NH H a bond NH 0 a bond Q3a OH
129 CMe 0 QIa NH Me a bond NH S NH Q3a OH
130 CMe 0 QIa NH Me a bond NH S a bond Q3a OH
131 CMe 0 QIa NH Me a bond NH 0 NH Q3a OH
132 CMe 0 QIa NH Me a bond NH 0 a bond Q3a OH
133 CMe 0 QIa NH H a bond NH S NH Q3a OH
134 CMe 0 QIa NH H a bond NH S a bond Q3a OH
135 CMe 0 QIa NH H a bond NH 0 NH Q3a OH
136 CMe 0 QIa NH H a bond NH 0 a bond Q3a OH
137 CMe 0 QIb NH Me a bond NH S NH Q3a OH
138 CMe 0 QIb NH Me a bond NH S a bond Q3a OH
139 CMe 0 QIb NH Me a bond NH 0 NH Q3a OH
140 CMe 0 QIb NH Me i bone 1 NH 0 a bond Q3a 0 141 CMe 0 QIb NH H a bond NH S NH Q3a OH
142 CMe 0 QIb NH H a bond NH S a bond Q3a OH
143 CMe 0 QIb NH H a bond NH 0 NH Q3a OH
144 CMe 0 QIb NH H a bond NH 0 a bond Q3a OH
145 N NMe QIa 0 Me a bond NH S NH Q3a OH
146 N NMe QIa 0 Me a bond NH S a bond Q3a OH
147 N NMe QIa 0 Me a bond NH 0 NH Q3a OH
148 N NMe QIa 0 Me a bond NH 0 a bond Q3a OH
149 N NMe QIa 0 H a bond NH S NH Q3a ( )H
150 N NMe QIa 0 H a bond NH S a bond Q3a OH
151 N NMe QIa 0 H a bond NH 0 } Φi Q3a ( )H
152 N NMe QIa 0 H a bond NH 0 a bond Q3a OH
153 N NMe QIb 0 Me a bond NH S NH Q3a OH
154 N NMe QIb 0 Me a bond NH S a bond Q3a OH
155 N NMe QIb 0 Me a bond NH 0 NH Q3a OH
156 N NMe QIb 0 Me a bond NH 0 a bond Q3a OH
157 N NMe QIb 0 H a bond NH S ϊffl Q3a ( )H
158 N NMe QIb 0 H a bond NH S a bond Q3a OH
159 N NMe QIb 0 H a bond NH 0 Iffl Q3a ( )H
160 N NMe QIb 0 H a bond NH 0 a bond Q3a OH
161 N S QIa 0 Me a bond NH S NH Q3a OH
162 N S QIa 0 Me a bond NH S a bond Q3a OH
163 N S QIa 0 Me a bond NH 0 NH Q3a OH
164 N S QIa 0 Me a bond NH 0 a bond Q3a OH
165 N S QIa 0 H a bond NH S ϊffl Q3a OH
166 N S QIa 0 H a bond NH S a bond Q3a OH
167 N S QIa 0 H a bond NH 0 Iffl Q3a OH
168 N S QIa 0 H a bond NH 0 a bond Q3a OH
169 N S QIb 0 Me a bond NH S NH Q3a OH
170 N S QIb 0 Me a bond NH S a bond Q3a OH
171 N S QIb 0 Me a bond NH 0 NH Q3a OH
172 N S QIb 0 Me a bond NH 0 a bond Q3a OH
173 N S QIb 0 H a bond NH S NH Q3a OH
174 N S QIb 0 H a bond NH S a bond Q3a OH
175 N S QIb 0 H a bond NH 0 I JH Q3a OH
176 N S QIb 0 H a bond NH 0 a bond Q3a OH 177 N 0 QIa 0 Me a bond NH S NH Q3a OH
178 N 0 QIa 0 Me a bond NH S a bond Q3a OH
179 N 0 QIa 0 Me a bond NH 0 NH Q3a OH
180 N 0 QIa 0 Me a bond NH 0 a bond Q3a OH
181 N 0 QIa 0 H a bond NH S I M Q3a OH
182 N 0 QIa 0 H a bond NH S a bond Q3a OH
183 N 0 QIa 0 H a bond NH 0 f M Q3a OH
184 N 0 QIa 0 H a bond NH 0 a bond Q3a OH
185 N 0 QIb 0 Me a bond NH S NH Q3a OH
186 N 0 QIb 0 Me a bond NH S a bond Q3a OH
187 N 0 QIb 0 Me a bond NH 0 NH Q3a OH
188 N 0 QIb 0 Me a bond NH 0 a bond Q3a OH
189 N 0 QIb 0 H a bond NH S Iffl Q3a OH
190 N 0 QIb 0 H a bond NH S a bond Q3a OH
191 N 0 QIb 0 H a bond NH 0 ϊ M Q3a OH
192 N 0 QIb 0 H a bond NH 0 a bond Q3a OH
193 CH NMe QIa 0 Me a bond NH S NH Q3a OH
194 CH NMe QIa 0 Me a bond NH S a bond Q3a OH
195 CH NMe QIa 0 Me a bond NH 0 NH Q3a OH
196 CH NMe QIa 0 Me a bond NH 0 a bond Q3a OH
197 CH NMe QIa 0 H a bond NH S NH Q3a OH
198 CH NMe QIa 0 H a bond NH S a bond Q3a OH
199 CH NMe QIa 0 H a bond NH 0 NH Q3a OH
200 CH NMe QIa 0 H a bond NH 0 a bond Q3a OH
201 CH NMe QIb 0 Me ' a bond NH S NH Q3a OH
202 CH NMe QIb 0 Me a bond NH S a bond Q3a OH
203 CH NMe QIb 0 Me a bond NH 0 NH Q3a OH
204 CH NMe QIb 0 Me a bond NH 0 a bond Q3a OH
205 CH NMe QIb 0 H a bond NH S NH Q3a OH
206 CH NMe QIb 0 H a bond NH S a bond Q3a OH
207 CH NMe QIb 0 H a bond NH 0 NH Q3a OH
208 CH NMe QIb 0 H a bond NH 0 a bond Q3a OH
209 CH S QIa 0 Me ; a bond NH S NH Q3a OH
210 CH S QIa 0 Me 5 a bond NH S i bond Q3a OH
211 CH S QIa 0 Me ; a bond NH 0 NH Q3a OH
212 CH S QIa 0 Mej a bond NH 0 i . bond Q3a OH 213 CH S QIa 0 H a bond NH S NH Q3a OH
214 CH S QIa 0 H a bond NH S a bond Q3a OH
215 CH S QIa 0 H a bond NH 0 NH Q3a OH
216 CH S QIa 0 H a bond NH 0 a bond Q3a OH
217 CH S QIb 0 Me a bond NH S NH Q3a OH
218 CH S QIb 0 Me a bond NH S a bone 1 Q3a OH'
219 CH S QIb 0 Me a bond NH 0 NH Q3a OH
220 CH S QIb 0 Me a bond NH 0 a bone 1 Q3a . OH
221 CH S QIb 0 H a bond NH S NH Q3a OH
222 CH S QIb 0 H a bond NH S a bond Q3a OH
223 CH S QIb 0 H a bond NH 0 NH Q3a OH
224 CH S QIb 0 H a bond NH 0 a bond Q3a OH
225 CH 0 QIa 0 Me a bond NH S NH Q3a OH
226 CH 0 QIa 0 Me a bond NH S a bone 1 Q3a OH
227 CH 0 QIa 0 Me a bond NH 0 NH Q3a OH
228 CH 0 QIa 0 Me a bond NH 0 a bone 1 Q3a OH
229 CH 0 QIa 0 H a bond NH S NH Q3a OH
230 CH 0 QIa 0 H a bond NH S a bond Q3a OH
231 CH 0 QIa 0 H a bond NH 0 NH Q3a OH
232 CH 0 QIa 0 H a bond NH 0 a bond Q3a OH
233 CH 0 QIb 0 Me a bond NH S NH Q3a OH
234 CH 0 QIb 0 Me a bond NH S a bone 1 Q3a OH
235 CH 0 QIb 0 Me a bond NH 0 NH Q3a OH
236 CH 0 QIb 0 Me a bond NH 0 a bone 1 Q3a OH
237 CH 0 QIb 0 H a bond NH S NH Q3a OH
238 GH 0 QIb 0 H a bond NH S a bond Q3a OH
239 CH 0 QIb 0 H a bond NH 0 NH Q3a OH
240 CH 0 QIb- 0 H. a bond NH 0 a bond Q3a OH •
241 CMe Me QIa 0 Me i bone 1 Nl I S NH Q3a OH
242 CMe NMe QIa 0 Me i bone 1 Nl 1 S a bond Q3a OH
243 CMe Me QIa 0 Me 'ci bone 1 M 1 0 NH Q3a OH
244 CMe Me QIa 0 Me i bone 1 Nl I 0 a bond Q3a OH
245 CMe Me QIa 0 H a bond NH S NH Q3a ,0H
246 CMe Me QIa 0 H a bond NH S a bone I Q3a OH
247 CMe Me QIa 0 H a bond NH 0 .NH Q3a OH 248 CMe NMe QIa 0 H a bond NH 0 a bond Q3a OH
249 CMe NMe QIb 0 Me a bond NH S NH Q3a OH
250 CMe NMe QIb 0 Me a bond NH S a bond Q3a OH
251 CMe NMe QIb 0 Me a bond NH 0 NH Q3a OH
252 CMe NMe QIb 0 Me a bond NH 0 a bond Q3a OH
253 CMe NMe QIb 0 H a bond NH S NH Q3a ( )H
254 CMe NMe QIb 0 H a bond NH S a bond Q3a OH
255 CMe NMe QIb 0 H a bond NH 0 NH Q3a ( )H
256 CMe NMe QIb 0 H a bond NH 0 a bond Q3a OH
257 CMe S QIa 0 Me a bond NH S NH Q3a OH
258 CMe S QIa 0 Me a bond NH S a bond Q3a OH
259 CMe S QIa 0 Me a bond NH 0 NH Q3a OH
260 CMe S QIa 0 Me a bond NH 0 a bond Q3a OH
261 CMe S QIa 0 H a bond NH S NH Q3a ( DH
262 CMe S QIa 0 H a bond NH S a bond Q3a OH
263 CMe S QIa 0 H a bond NH 0 NH Q3a ( )H
264 CMe S QIa 0 H a bond NH 0 a bond Q3a OH
265 CMe S QIb 0 Me a bond NH S NH Q3a OH
266 CMe S QIb 0 Me a bond NH S a bond Q3a OH
267 CMe S QIb 0 Me a bond NH 0 NH Q3a OH
268 CMe S QIb 0 Me a bond NH- 0 a bond Q3a OH
269 CMe S QIb 0 H a bond NH S NH Q3a ( )H
270 CMe S QIb 0 H a bond NH S a bond Q3a OH
271 CMe . S QIb 0 H a bond- NH 0 NH Q3a ( )H
272 CMe S QIb 0 H a bond NH 0 a bond Q3a OH
273 CMe . 0 QIa 0 Me a bond NH S NH Q3a OH
274 CMe 0 QIa 0 Me a bond NH S a bond Q3a OH
275 CMe .0 QIa 0 Me a bond NH 0 NH Q3a OH
276' CMe 0 QIa 0 Me a bond NH 0 a bond Q3a OH
277 CMe 0 QIa 0 H a bond NH S NH Q3a OH
278 CMe 0 QIa o- H a bond NH S a bond Q3a OH
279 CMe 0 QIa 0 H a bond NH 0 NH Q3a OH
280 CMe 0 QIa 0 H a bond NH 0 a bond Q3a OH
281 CMe 0 QIb 0 Me a bond NH S NH Q3a OH
282 CMe 0 QIb 0 Me a bond NH S a bond Q3a OH
283 CMe 0 QIb 0 Me a bond NH 0 . NH Q3a OH 284 CMe 0 QIb 0 Me a bond NH 0 a bond Q3a OH
285 CMe 0 QIb 0 H a bond NH S NH Q3a OH
286 CMe 0 QIb 0 H a bond NH S a bond Q3a OH
287 CMe 0 QIb 0 H a bond NH 0 NH Q3a OH
288 CMe 0 QIb 0 H a bond NH 0 a bond Q3a OH
289 N NMe QIa CH2 Me a bond NH S NH Q3a OH
290 N NMe QIa CH2 Me a bond NH S a bond Q3a OH
291 N NMe QIa CH2 Me a bond NH 0 NH Q3a OH
292 N NMe QIa CH2 Me a bond NH 0 a bond Q3a OH
293 N NMe QIa CH2 H a bond NH S NH Q3a OH
294 N NMe QIa CH2 H a bond NH S a bond Q3a OH
295 N NMe QIa CH2 H a bond NH 0 NH Q3a OH
296 N NMe QIa CH2 H a bond NH 0 a bond Q3a OH
297 N NMe QIb CH2 Me a bond NH S NH Q3a OH
298 N NMe QIb CH2. Me a bond NH S a bond Q3a OH
299 N NMe QIb CH2 Me a bond NH 0 NH Q3a OH
300 N NMe QIb CH2 Me a bond NH 0 a bond Q3a OH
301 N NMe QIb CH2 H a bond NH S NH Q3a OH
302 N NMe QIb CH2 H a bond NH S a bond Q3a OH
303 N NMe QIb CH2 H a bond NH 0 NH Q3a OH
304 N NMe QIb CH2 H a bond NH 0 a bond Q3a OH
305 N S QIa CH2 Me a bond NH S NH Q3a OH
306 N S QIa CH2 Me a bond NH S .i bond Q3a .0H
307 N S QIa- CH2 Me a bond NH 0 NH Q3a OH
308 N S QIa CH2 Me a bond NH 0 .i bond Q3a OH
309' N S QIa CH2 H a bond NH S NH Q3a, OH
310 N S QIa CH2 H a bond NH S a bond Q3a OH
311 N S QIa CH2 H . a bond NH 0 NH Q3a OH
312 N S QIa CH2 H a bond NH 0 a bond Q3a OH
313 N S QIb CH2 Me a bond NH S NH Q3a OH
314 N S QIb CH2 Me a bond NH S <i bond Q3a OH
315 N S QIb CH2 Me a bond NH 0 NH Q3a OH
316 N S QIb CH2 Me a bond NH 0 <i bond Q3a OH
317 N S QIb CH2 H a bond NH S NH Q3a OH
318 N S QIb CH2 H a bond NH S a bond Q3a OH
319 N S QIb CH2 H a bond NH 0 NH Q3a OH 320 N S QIb CH2 H a bond NH 0 a bond Q3a OH
321 N 0 QIa CH2 Me a bond NI I S NH Q3a OH
322 N 0 QIa CH2 Me a bond NI 1 S a bond Q3a OH
323 N 0 QIa CH2 Me a bond NIi 0 NH Q3a OH
324 N 0 QIa CH2 Me a bond NI 1 0 a bond Q3a OH
325 N 0 QIa CH2 H a bond NH S Iffl Q3a OH
326 N 0 QIa CH2 H a bond NH S a bond Q3a OH
327 N 0 QIa CH2 H a bond NH 0 ϊtø Q3a OH
328 N 0 QIa CH2 H a bond NH 0 a bond Q3a OH
329 N 0 QIb CH2 Me a bond NI I S NH Q3a OH
330 N 0 QIb CH2 Me a bond NI I S a bond Q3a OH
331 N 0 QIb CH2 Me a bond NI I 0 NH Q3a OH
332 N 0 QIb CH2 Me a bond NI I 0 a bond Q3a OH
333 N 0 QIb CH2 H a bond NH S Iffl Q3a OH
334 N 0 QIb CH2 H a bond NH S a bond Q3a OH
335 N 0 QIb CH2 H a bond NH 0 I M Q3a OH
336 N 0 QIb CH2 H a bond NH 0 a bond Q3a OH
337 CH NMe QIa CH2 Me a bond NH S NH Q3a OH
338 CH NMe QIa CH2 Me a bond NH S a bond Q3a OH
339 CH • NMe QIa CH2 Me a bond NH 0 NH Q3a OH
340 CH NMe QIa CH2 Me a bond NH 0 a bond Q3a OH
341 CH NMe QIa CH2 H a bond NH S NH Q3a OH
342 CH NMe QIa CH2 H a bond NH S a bond Q3a OH
343 CH NMe QIa CH2 H a bond NH 0 NH Q3a OH
344 CH NMe QIa ' CH2 H a bond NH 0 a bond Q3a OH
345 CH NMe QIb CH2 Me a bond NH S NH- Q3a OH
346 CH NMe QIb CH2 Me a bond NH S a bond Q3a OH
347 CH NMe QIb CH2 Me a bond NH 0 NH Q3a OH
348 CH NMe QIb CH2 Me a bond NH 0 a bond Q3a OH
349 CH NMe QIb CH2 H a bond NH S NH Q3a OH
350 CH NMe QIb CH2 H a bond NH S a bond Q3a OH
35,1 CH NMe QIb CH2 H a bond NH 0 NH Q3a OH
352 CH NMe QIb CH2 H a bond NH 0 a bond Q3a OH
353 CH S QIa CH2 Mf a bond I M I NH Q3a OH
354 CH . S QIa CH2 Mea a bond NH 5 5 ci bond Q3a OH
355 CH S QIa CH2 Me a bond NH ( ) NH Q3a OH 356 CH S QIa CH2 Me a bond NH 0 a bond Q3a OH
357 CH S QIa CH2 H a bond NH S NH Q3a OH
358 CH S QIa CH2 H a bond NH S a bond Q3a OH
359 CH S QIa CH2 H a bond NH 0 NH Q3a OH
360 CH S QIa CH2 H a bond NH 0 a bond Q3a OH
361 CH S QIb CH2 Me a bond NH S NH Q3a OH
362 CH S QIb CH2 Me a bond NH S a bond Q3a OH
363 CH S QIb CH2 Me a bond NH 0 NH Q3a OH
364 CH S QIb CH2 Me a bond NH 0 a bond Q3a OH
365 CH S QIb CH2 H a bond NH S NH Q3a OH
366 CH S QIb CH2 H a bond NH S a bond Q3a OH
367 CH S QIb CH2 H a bond NH 0 NH Q3a OH
368 CH S QIb CH2 H a bond NH 0 a bond Q3a OH
369 CH 0 QIa CH2 Me a bond NH S NH Q3a OH
370 CH 0 QIa CH2 Me a bond NH S a bone 1 Q3a OH
371 CH 0 QIa CH2 Me a bond NH 0 NH Q3a OH
372 CH 0 QIa CH2 Me a bond NH 0 a bond Q3a OH
373 CH 0 QIa CH2 H a bond NH S NH Q3a OH
374 CH 0 QIa CH2 H a bond NH S a bond Q3a OH
375 CH 0 QIa CH2 H a bond NH 0 NH Q3a OH
376 CH 0 QIa CH2 H a bond NH 0 a bond Q3a OH
377 CH 0 QIb CH2 Me a bond NH S NH Q3a . OH
378 CH 0 QIb CH2 Me a bond NH S a bone 1 Q3a OH
379 CH 0 QIb CH2 Me a bond NH 0 NH Q3a OH
380 CH 0 QIb CH2 Me a bond NH 0 a bone 1 Q3a OH
381 CH ' 0 QIb CH2 H a bond NH S NH" Q3a ■ OH
382 CH 0 QIb CH2 H a bond NH S a bond Q3a OH
383 CH 0 QIb CH2 H. a bond NH 0 NH Q3a OH
384 CH 0 QIb CH2 H a bond NH 0 a bond Q3a OH
385 CMe NMe QIa CH2 Me Ϊ bone 1 NP I S NH Q3a OH
386 CMe NMe QIa CH2 Me i bone I Nt I S a bond Q3a OH
387 CMe NMe QIa CH2 Me' i bone 1 Nt I 0 NH Q3a OH
388 CMe NMe QIa CH2 Me i bone 1 Nt 1 0 a bond Q3a OH
389 CMe NMe QIa CH2 H bond NH S NH Q3a OH
390 CMe NMe QIa CH2 H a bond NH S a bone 1 Q3a OH
391 CMe NMe QIa CH2 H a bond NH 0 Ml Q3a OH 392 CMe NMe QIa CH2 H a bond NH 0 a bond Q3a OH
393 CMe NMe QIb CH2 Me a bond NH S NH Q3a OH
394 CMe NMe QIb CH2 Me a bond NH S a bond Q3a OH
395 CMe NMe QIb CH2 Me a bond NH 0 NH Q3a OH
396 CMe NMe QIb CH2 Me a bond NH 0 a bond Q3a OH
397 CMe NMe QIb CH2 H a bond NH S NH Q3a ( )H
398 CMe NMe QIb CH2 H a bond NH S a bond Q3a OH
399 CMe NMe QIb CH2 H a bond NH 0 NH Q3a ( )H
400 CMe NMe QIb CH2 H a bond NH 0 a bond Q3a OH
401 CMe S QIa CH2 Me a bond NH S NH Q3a OH
402 CMe S QIa CH2 Me a bond NH S a bond Q3a OH
403 CMe S QIa CH2 Me a bond NH 0 NH Q3a OH
404 CMe S QIa CH2 Me a bond NH 0 a bond Q3a OH
405 CMe S QIa CH2 H a bond NH S NH Q3a ( )H
406 CMe S QIa CH2 H a bond NH S a bond Q3a OH
407 CMe S QIa CH2 H a bond NH 0 NH Q3a ( )H
408 CMe S QIa CH2 H a bond NH 0 a bond Q3a OH
409 CMe S QIb CH2 Me a bond NH S NH Q3a OH
410 CMe S QIb CH2 Me a bond NH S a bond Q3a OH
411 CMe S QIb CH2 Me a bond NH 0 NH Q3a OH
412 CMe S QIb CH2 Me a bond NH 0 a bond Q3a OH
413 CMe S QIb CH2 H a bond NH S NH Q3a ( )H
414 CMe' S QIb CH2 H a bond NH S a bond Q3a OH
415 CMe S QIb CH2 H a bond NH 0 NH Q3a ( )H
416 CMe S QIb CH2 H a bond NH 0 a bond Q3a OH
417 CMe 0 QIa CH2 Me a bond ■ NH S NH Q3a OH
418 CMe 0 QIa CH2 Me a bond NH S a bond Q3a OH
419 CMe 0 QIa CH2 Me a bond NH 0 NH Q3a OH
420 •CMe 0 QIa CH2 Me a bond NH 0 a bond Q3a OH
421 CMe 0 QIa CH2 H a bond NH S NH Q3a ( )H
422 CMe 0 QIa CH2 H a bond NH S a bond Q3a OH
423 CMe 0 QIa CH2 H a bond NH 0 NH Q3a ( )H
424 CMe 0 QIa CH2 H a bond NH 0 a bond Q3a OH
425 CMe 0 QIb CH2 Me a bond NH S NH Q3a OH
426 CMe 0 QIb CH2 Me a bond NH S a bond Q3a OH
427 CMe 0 QIb CH2 Me a bond NH 0 . NH Q3a OH 428 CMe 0 QIb CH2 Me a bond NH 0 a bond Q3a OH
429 CMe 0 QIb CH2 H a bond NH S NH Q3a OH
430 CMe 0 QIb CH2 H a bond NH S a bond Q3a OH
431 CMe 0 QIb CH2 H a bond NH 0 NH Q3a OH
432 CMe 0 QIb CH2 H a bond NH 0 a bond Q3a OH
433 N NMe QIa a bond Me a bond I S CH2 Q3a OH
434 N NMe QIa a bond Me a bond I 0 CH2 Q3a OH
435 N NMe QIa a bond H a bond NH S CH2 Q3a OH
436 N NMe QIa a bond H a bond NH 0 CH2 Q3a OH
437 N NMe QIb a bond Me a bond Im S CH2 Q3a OH
438 N NMe QIb a bond Me a bond Im 0 CH2 Q3a OH
439 N NMe QIb a bond H a bond NIi S CH2 Q3a OH
440 N NMe QIb a bond H a bond NH 0 CH2 Q3a OH
441 N S QIa a bond Me a bond NH S CH2 Q3a OH
442 N S QIa a bond Me a bond NH 0 CH2 Q3a OH
443 N S QIa a bond H a bond NH S CH2 Q3a OH
444 N S QIa a bond H a bond NH 0 CH2 Q3a OH
445 N S QIb a bond Me a bond NH S CH2 Q3a OH
446 N S QIb a bond Me a bond NH 0 CH2 Q3a OH
447 N S QIb a bond H a bond NH S CH2 Q3a OH
448 N S QIb a bond H a bond NH 0 CH2 Q3a OH
449 N 0 QIa a bond Me a bond NH S CH2 Q3a OH
450 N 0 QIa a bond Me a bond NH 0 CH2 Q3a OH
451 N 0 QIa a bond H a bond NH S CH2 Q3a OH
452 N 0 QIa a bond H a bond NH 0 CH2 Q3a OH
453 N 0 QIb a bond Me a bond NH S ■ CH2 Q3a OH
454 N 0 QIb a bond Me a bond NH 0 CH2 Q3a OH
455 N 0 QIb a bond H a bond NH S CH2 Q3a OH
456 N 0 QIb a bond H a bond NH 0 CH2 Q3a OH
457 CH NMe QIa a bond Me a bond NH S CH2 Q3a OH
458 CH NMe QIa a bond Me a bond NH 0 CH2 Q3a OH
459 CH NMe QIa a bond H a bond } M S CH2 Q3a OH
460 CH NMe QIa a bond H a bond f M 0 CH2 Q3a OH
461 CH NMe QIb a bond Me a bond NH S CH2 Q3a ' OH
462 CH NMe QIb a bond Me a bond NH 0 CH2 Q3a OH
463 CH NMe QIb a bond H a bond } S. CH2 Q3a OH 464 CH NMe QIb a bond H a bond NH O CH2 Q3a OH
465 CH S QIa a bond Me a bond NH S CH2 Q3a OH
466 CH S QIa a bond Me a bond NH 0 CH2 Q3a OH
467 CH S QIa a bond H a bond NH S CH2 Q3a OH 468 CH S QIa a bond H a bond NH 0 CH2 Q3a OH
469 CH S QIb a bond Me a bond NH S CH2 Q3a OH
470 CH S QIb a bond Me a bond NH 0 CH2 Q3a OH
471 CH S QIb a bond H a bond NH S CH2 Q3a OH
472 CH S QIb a bond H a bond NH 0 CH2 Q3a OH 473 CH 0 QIa a bond Me a bond NH S CH2 Q3a OH
474 CH 0 QIa a bond Me a bond NH 0 CH2 Q3a OH
475 CH 0 QIa a bond H a bond NH S CH2 Q3a OH
476 CH 0 QIa a bond H a bond NH 0 CH2 Q3a OH
477 CH 0 QIb a bond Me a bond NH S CH2 Q3a OH 478 CH 0 QIb a bond Me a bond NH 0 CH2 Q3a OH
479 CH 0 QIb a bond H a bond NH S CH2 Q3a OH
480 CH 0 QIb a bond H a bond NH 0 CH2 Q3a OH
481 CMe NMe QIa a bond Me a bond NH S CH2 Q3a OH
482 CMe NMe QIa a bond Me a bond NH 0 CH2 Q3a OH 483 CMe NMe QIa a bond H a bond NH S CH2 Q3a OH
484 CMe NMe QIa a bond H a bond NH 0 CH2 Q3a OH
485 CMe NMe QIb a bond Me a bond NH S CH2 Q3a OH
486 CMe NMe QIb a bond Me a bond NH 0 CH2 Q3a OH
487 CMe NMe QIb a bond H a bond NH S CH2 Q3a OH 488 CMe NMe QIb a bond H a bond NH 0 CH2 Q3a OH
489 CMe S QIa a bond Me a bond NH S CH2 Q3a OH
490 CMe S QIa a bond Me a bond NH 0 CH2 Q3a OH
491 CMe S QIa a bond H a bond NH S CH2 Q3a OH
492 CMe S QIa a bond H a bond NH 0 CH2 Q3a OH 493 CMe S QIb a bond Me a bond NH S CH2 Q3a OH
494 CMe S QIb a bond Me a bond NH 0 CH2 Q3a OH
495 CMe S QIb a bond H a bond NH S CH2 Q3a OH
496 CMe S QIb a bond H a bond NH 0 CH2 Q3a OH
497 CMe 0 QIa a bond Me a bond NH S CH2 Q3a OH 498 CMe 0 QIa a bond Me a bond NH 0 CH2 Q3a OH
499 CMe 0 QIa a bond H a bond NH S CH2 Q3a OH 500 CMe 0 QIa a bond H a bond NH 0 CH2 Q3a OH
501 CMe 0 QIb a bond Me a bond NH S CH2 Q3a OH
502 CMe 0 QIb a bond Me a bond NH 0 CH2 Q3a OH
503 CMe 0 QIb a bond H a bond NH S CH2 Q3a OH
504 CMe 0 QIb a bond H a 'bond NH 0 CH2 Q3a OH
505 N NMe QIa a bond Me a bond CH2 S a bond Q3a OH
506 N NMe QIa a bond Me a bond CH2 S NH Q3a OH
507 N NMe QIa a bond Me a bond CH2 0 a bond Q3a OH
508 N NMe QIa a bond Me a bond CH2 0 NH Q3a OH
509 N NMe QIa a bond H a ' bond CH2 S a bond Q3a OH
510 N NMe QIa a bond H a bond CH2 S NH Q3a OH
511 N NMe QIa a bond H a bond CH2 0 a bond Q3a OH
512 N NMe QIa a bond H a bond CH2 0 NH Q3a OH
513 N NMe QIb a bond Me a bond CH2 S a bond Q3a OH
514 N NMe QIb a bond Me a bond CH2 S NH Q3a OH
515 N NMe QIb a bond Me a bond CH2 0 a bond Q3a OH
516 N NMe QIb a bond Me a bond CH2 0 NH Q3a OH
517 N NMe QIb a bond H a bond CH2 S a bond Q3a OH
518 N NMe QIb a bond H a bond CH2 S NH Q3a OH
519 N NMe QIb a bond H a bond CH2 0 a bond Q3a OH
520 N NMe QIb a bond H a bond CH2 0 NH Q3a OH
521 N S QIa a bond Me a bond CH2 S ∑i bond Q3a OH
522 N S QIa a bond Me a bond CH2 S NH Q3a OH
523 N S QIa a bond Me a bond CH2 0 ii bond Q3a OH
524 N S QIa a bond Me a bond CH2 0 NH Q3a OH
525 N S QIa a bond H a bond' CH2 S a bond Q3a OH
526 N S QIa a bond H a bond CH2 S NH Q3a OH
527 N S QIa a bond H a bond CH2 0 a bond Q3a OH
528 N S QIa a bond H a bond CH2 0 NH Q3a OH
529 N S QIb a bond Me a bond CH2 S ∑i bond Q3a OH
530 N S QIb a bond Me a bond CH2 S NH Q3a OH
531 N S QIb a bond Me a bond CH2 0 ii bond Q3a OH
532 N S QIb a bond Me a bond CH2 0 NH Q3a OH
533 N S QIb a bond H a bond CH2 S a bond Q3a OH
534 N S QIb a bond H a bond CH2 S NH Q3a OH
535 N S QIb a bond H a bond CH2 0 a bond Q3a OH 536 N S QIb a bond H a bond CH2 0 NH Q3a OH
537 N 0 QIa a bond Me a bond CH2 S a bond Q3a OH
538 N 0 QIa a bond Me a bond CH2 S NH Q3a OH
539 N 0 QIa a bond Me a bond CH2 0 a bond Q3a OH 540 N 0 QIa a bond Me a bond CH2 0 NH Q3a OH
541 N 0 QIa a bond H a bond CH2 S a bond Q3a OH
542 N 0 QIa a bond H a bond CH2 S NH Q3a OH
543 N 0 QIa a bond H a bond CH2 0 a bond Q3a OH
544 N 0 QIa a bond H a bond CH2 0 NH Q3a OH 545 N 0 QIb a bond Me a bond CH2 S a bond Q3a OH
546 N 0 QIb a bond Me a bond CH2 S NH Q3a OH
547 N 0 QIb . a bond Me a bond CH2 0 a bond Q3a OH
548 N 0 QIb a bond Me a bond CH2 0 NH Q3a OH
549 N 0 QIb a bond H a bond CH2 S a bond Q3a OH 550 N 0 QIb a bond H a bond CH2 S NH Q3a OH
551 N 0 QIb a bond H a bond CH2 0 a bond Q3a OH
552 N 0 QIb a bond H a bond CH2 0 NH Q3a OH
553 CH NMe QIa a bond Me a bond CH2 S a bond Q3a OH
554 CH NMe QIa a bond Me a bond CH2 S NH Q3a OH 555 CH NMe QIa a bond Me a bond CH2 0 a bond Q3a OH
556 CH NMe QIa a bond Me a bond CH2 0 NH Q3a OH
■ 557 CH NMe QIa a bond H a bond CH2 S a bond Q3a OH
558 CH NMe QIa a bond H a bond CH2 S NH Q3a OH
559 CH NMe QIa a bond H a bond CH2 0 a bond Q3a OH 560 CH NMe QIa a bond H a bond CH2 0 NH Q3a OH 561 CH NMe QIb a bond •Me . a• bond CH2 S a bond Q3a OH
562 CH NMe QIb ,a bond Me a bond' CH2 S NH. Q3a OH
563 CH NMe QIb a bond Me a bond CH2 0 a bond Q3a OH
564 CH NMe QIb a bond Me a bond CH2 0 NH Q3a OH 565 CH NMe QIb a bond H a bond CH2 S a bond Q3a OH
566 CH NMe QIb a bond H a bond CH2 S NH Q3a OH
567 CH NMe QIb a bond H a bond CH2 0 a bond Q3a OH
568 CH NMe QIb a bond H a bond CH2 0 NH Q3a OH
569 CH S QIa a bond Me a bond CH2 S a bond Q3a OH 570 CH S QIa a bond Me a bond CH2 S NH Q3a OH
571 CH S QIa a bond Me a bond CH2 O a bond Q3a OH 572 CH S QIa a bond Me a bond CH2 0 NH Q3a OH
573 CH S QIa a bond H a bond CH2 S a bond Q3a OH
574 CH S QIa a bond H a bond CH2 S NH Q3a OH
575 CH S QIa a bond H a bond CH2 0 a bond Q3a OH
576 CH S QIa a bond H a bond CH2 0 NH Q3a OH
577 CH S QIb a bond Me a bond CH2 S a bond Q3a OH
578 CH S QIb a bond Me a bond CH2 S NH Q3a OH
579 CH S QIb a bond Me a bond CH2 0 a bond Q3a OH
580 CH S QIb a bond Me a bond CH2 0 NH Q3a OH
581 CH S QIb a bond H a bond CH2 S a bond Q3a OH
582 CH S QIb a bond H a bond CH2 S NH Q3a OH
583 CH S QIb a bond H a bond CH2 0 a bond Q3a OH
584 CH S QIb a bond H a bond CH2 0 NH Q3a OH
585 CH 0 QIa a bond Me a bond CH2 S a bond Q3a OH
586 CH 0 QIa a bond Me a bond CH2 S NH Q3a OH
587 CH 0 QIa a bond Me a bond CH2 0 a bond Q3a OH
588 CH 0 QIa a bond Me a bond CH2 0 NH Q3a OH
589 CH 0 QIa a bond H a bond CH2 S a bond Q3a OH
590 CH 0 QIa a bond H a bond CH2 S NH Q3a OH
591 CH 0 QIa a bond H a bond CH2 0 a bond Q3a OH
592 CH 0 QIa a bond H a bond CH2 0 NH Q3a OH
593 CH 0 QIb a bond Me a bond CH2 S a bond Q3a OH
594 CH 0 QIb a bond Me a bond CH2 S "NH Q3a OH
595 CH 0 QIb a bond Me a bond CH2 0 a bond Q3a OH
596 CH 0 QIb a bond Me a bond CH2 0 NH Q3a OH
597- CH 0 QIb a bond H a bond CH2 S a bond Q3a OH
598 CH 0 QIb a bond H a bond CH2 S NH Q3a OH
599 CH 0 QIb a bond H a bond CH2 0 a bond Q3a OH
600 CH 0 QIb a bond H a bond CH2 0 NH Q3a OH
601 CMe NMe QIa a bond Me a bone 1 CH2 S a bond Q3a OH
602 CMe NMe QIa a bond Me a bone 1 -CH2 S NH Q3a OH
603 CMe NMe QIa a bond Me a bone 1 CH2 0 a bond Q3a OH
604 CMe NMe QIa a bond Me a bone 1 CH2 0 NH Q3a OH
605 CMe NMe QIa a bond H a bond CH2 S a bond Q3a OH
606 CMe NMe QIa a bond H a bond CH2 S NH Q3a OH
607 CMe NMe QIa a bond H a bond CH2 0. a bond Q3a OH 53<:
608 CMe NMe QIa a bond H a bond CH2 0 NH Q3a OH
609 CMe NMe QIb a bond Me a bond CH2 S a bond Q3a OH
610 CMe NMe QIb a bond Me a bond CH2 S NH Q3a OH
611 CMe NMe QIb a bond Me a bond CH2 0 a bond Q3a OH
612 CMe NMe QIb a bond Me a bond CH2 0 NH Q3a OH
613 CMe NMe QIb a bond H a bond CH2 S a bond Q3a OH
614 CMe NMe QIb a bond H a bond CH2 S NH Q3a OH
615 CMe NMe QIb a bond H a bond CH2 0 a bond Q3a OH
616 CMe NMe QIb a bond H a bond CH2 0 NH Q3a OH
617 CMe S QIa a bond Me a bond CH2 S a bond Q3a OH
618 CMe S QIa a bond Me a bond CH2 S NH Q3a OH
619 CMe S QIa a bond Me a bond CH2 0 a bond Q3a OH
620 CMe S QIa a bond Me a bond CH2 0 NH Q3a OH
621 CMe S QIa a bond H a bond CH2 S a bond Q3a OH
622 CMe S QIa a bond H a bond CH2 S NH Q3a OH
623 CMe S QIa a bond H a bond CH2 0 a bond Q3a OH
624 CMe S QIa a bond H a bond CH2 0 NH Q3a OH
625 CMe S QIb a bond Me a bond CH2 S a bond Q3a OH
626 CMe S QIb a bond Me a bond CH2 S NH Q3a OH
627 CMe S QIb a bond Me a bond CH2 0 a bond Q3a OH
628 CMe S QIb a bond Me a bond CH2 0 NH Q3a OH
629 CMe S QIb a bond H a bond CH2 S a bond Q3a OH
630 CMe S QIb a bond H a bond CH2 S NH Q3a OH
631 CMe S QIb a bond H a bond CH2 0 a bond Q3a OH
632 CMe S QIb a bond H a bond CH2 0 NH Q3a OH
633 CMe 0 QIa a bond Me a bond CH2 S a bond Q3a OH
634 CMe 0 QIa a bond Me a bond CH2 S NH Q3a OH
635 CMe 0 QIa a bond Me a bond CH2 0 a bond Q3a OH
636 CMe 0 QIa a bond Me a bond CH2 0 NH Q3a OH
637 CMe 0 QIa a bond H a bond CH2 S a bond Q3a OH
638 CMe 0 QIa a bond H a bond CH2 S NH Q3a OH
639 CMe 0 QIa a bond H a bond CH2 0 a bond Q3a OH
640 CMe 0 QIa a bond H a bond CH2 0 NH Q3a OH
641 CMe 0 QIb a bond Me a bond CH2 S a bond Q3a OH
642 CMe 0 QIb a bond Me a bond CH2 S NH Q3a OH
643 CMe 0 QIb a bond Me a bond CH2 0 a bond Q3a OH 644 CMe 0 QIb a bond Me a bond CH2 0 NH Q3a OH
645 CMe 0 QIb a bond H a bond CH2 S a bond Q3a OH
646 CMe 0 QIb a bond H a bond CH2 S NH Q3a H
647 CMe 0 QIb a bond H a bond CH2 0 a bond Q3a OH
648 CMe 0 QIb a bond H a 'bond CH2 0 NH Q3a O'H
649 CMe NH QIa NH Me a bond NH S NH Q3a OH
650 CMe NH QIa NH Me a bond NH S a bond Q3a OH
651 CMe NH QIa NH Me a bond NH 0 NH Q3a OH
652 CMe NH QIa NH Me a bond NH 0 a bond Q3a OH
653 CMe NH QIa NH H a bond NH S NH Q3a OH
654 CMe NH QIa NH H a bond NH S a bond Q3a OH
655 CMe NH QIa NH H a bond NH 0 NH Q3a OH
656 CMe NH QIa NH H a bond NH 0 a bond Q3a OH
657 CMe NH QIb NH Me a bond NH S NH Q3a OH
658 CMe NH QIb NH Me a bond NH S a bond Q3a OH
659 CMe NH QIb NH Me a bond NH 0 NH Q3a OH
660 CMe NH QIb NH Me a bond NH 0 a bond Q3a OH
661 CMe NH QIb NH H a bond NH S NH Q3a OH
662 CMe NH QIb NH H a bond NH S a bond Q3a OH
663 CMe NH QIb NH H a bond NH 0 NH Q3a OH
664 CMe NH QIb NH H a bond NH 0 a bond Q3a OH
665 CMe NH QIa 0 Me a bond NH S NH Q3a OH
666 CMe NH QIa 0 Me a bond NH S a bond Q3a OH
667 CMe NH QIa 0 Me a bond NH 0 NH Q3a OH
668 CMe NH QIa 0 Me a bond NH 0 a bond Q3a OH
669 CMe NH QIa 0 H a bond NH S NH Q3a OH
670 CMe NH QIa 0 H a bond NH S a bond Q3a OH
671 CMe NH QIa 0 H a bond NH 0 NH Q3a OH
672 CMe NH QIa 0 H a bond NH 0 a bond Q3a OH
673 CMe NH QIb 0 Me a bond NH S NH Q3a OH
674 CMe NH QIb 0 Me a bond NH S a bond Q3a OH
675 CMe NH QIb 0 Me a bond NH 0 NH Q3a OH
676 CMe NH QIb 0 Me a bond NH 0 a bond Q3a OH
677 CMe NH QIb 0 H a bond NH S NH Q3a OH
678 CMe NH QIb 0 H a bond NH S a bond Q3a OH
679 CMe NH QIb 0 H a bond NH 0 NH Q3a OH 680 CMe NH QIb 0 H a bond NH 0 a bond Q3a OH
681 CMe NH QIa CH2 Me a bond NH S NH Q3a OH
682 CMe NH QIa CH2 Me a bond NH S a bond Q3a OH
683 CMe NH QIa CH2 Me a bond NH 0 NH Q3a OH
684 CMe NH QIa CH2 Me a bond NH 0 a bond Q3a OH
685 CMe NH QIa CH2 H a bond NH S ϊ <H Q3a OH
686 CMe NH QIa CH2 H a bond NH S a bond Q3a OH
687 CMe NH QIa CH2 H a bond NH 0 I Q3a OH
688 CMe NH QIa CH2 H a bond NH 0 a bond Q3a OH
689 CMe NH QIb CH2 Me a bond NH S NH Q3a OH
690 CMe NH QIb CH2 Me a bond NH S a bond Q3a OH
691 CMe NH QIb CH2 Me a bond NH 0 NH Q3a OH
692 CMe NH QIb CH2 Me a bond NH 0 a bond Q3a OH
693 CMe NH QIb CH2 H a bond NH S I M Q3a OH
694 CMe NH QIb CH2 H a bond NH S a bond Q3a OH
695 CMe NH QIb CH2 H a bond NH 0 NH Q3a OH
696 CMe NH QIb CH2 H a bond NH 0 a bond Q3a OH
697 CMe NH QIa a bond Me a bond NH S CH2 Q3a OH
698 CMe NH QIa a bond Me a bond NH 0 CH2 Q3a OH
699- CMe NH QIa a bond H a bond NH S CH2 Q3a OH
700 CMe NH QIa a bond H a bond NH 0 CH2 Q3a OH
701 CMe NH QIb a bond Me a bond NH S CH2 Q3a OH
702 CMe NH QIb a bond Me a bond NH 0 CH2 Q3a OH
703 CMe NH QIb a bond H a bond NH S CH2 Q3a OH
704 CMe NH QIb. a bond H a bond NH 0 CH2 Q3a OH
705 CMe NH QIa a bond Me a bond CH2 S a bond Q3a OH
706 CMe NH QIa a bond Me a bond CH2 S NH Q3a OH
707 CMe NH QIa a bond Me a bond CH2 0 a bond Q3a OH
708 CMe NH QIa a bond Me a bond CH2 0 NH Q3a OH
709 CMe NH QIa a bond H a bond CH2 S a bond Q3a OH
710 CMe NH QIa a bond H a bond CH2 S NH Q3a OH
711 CMe NH QIa a bond H a bond CH2 0 a bond Q3a OH
712 CMe NH QIa a bond H a bond CH2 0 NH Q3a OH
713 CMe NH QIb a bond Me a bond CH2 S a bond Q3a OH
714 CMe NH QIb a bond Me a bond CH2 S NH Q3a OH
715 CMe NH QIb a bond Me a bond CH2 0 . a bond Q3a OH 716 CMe NH QIb a bond Me a bond CH2 0 NH Q3a OH
717 CMe NH QIb a bond H a bond CH2 S a bond Q3a OH
718 CMe NH QIb a bond H a bond CH2 S NH Q3a OH
719 CMe NH QIb a bond H a bond CH2 0 a bond Q3a OH 720 CMe NH QIb a bond H a bond CH2 0 NH Q3a OH
63) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 3, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 63) , QIa, QIb and Q3a in Table 3 denote the following substituents) .
Figure imgf000540_0001
64) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table
2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 64) , QIa, QIb, QIc, QIi, QIj, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 2 denote the following substituents) .
Figure imgf000541_0001
65) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 65) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000542_0001
66) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 66) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi,- QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g'and Q3h in Table 1 denote the following substituents) .
Figure imgf000543_0001
67) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the. following combinations in Table I7 tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 67) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000544_0001
68) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 68) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000545_0001
69) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 69) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj,- QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) . Me
Q1a = \ -^-Me Q1k= Q3a= — N N-7 Me S Me
H
Figure imgf000546_0001
70) The compounds wherein A, B, R1, L1, R2, L2, L3, Y7 L4, R3 and X are any of the following combinations in Table 1, tautomers , prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 70) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj,- QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000547_0001
71) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 71) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl'', QIm', QIn', Q3a, . Q3b, Q3c, Q3d, Q3e, Q3f , Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000548_0001
72) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 72) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000549_0001
73) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 73) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000550_0001
74) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 74) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl' , QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000551_0001
75) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 75) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000552_0001
76) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 76) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents)
Figure imgf000553_0001
77) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 77) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn' , Q3a, Q3b, Q3c, Q3d, Q3e, Q3f , Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000554_0001
78) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 78) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000555_0001
79) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 79) , QIa7 QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl' , QIm', ' QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000556_0001
80) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 80) , QIa, QIb, QIc, QId,- QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl' , QIm' , QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000557_0001
81) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomerS) prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 81) , QIa, QIb, QIc, QId, QIe, QIf, QIg, QIh, QIi, QIj, QIk, QIl, QIm, QIn, QIk', QIl', QIm', QIn', Q3a, Q3b, Q3c, Q3d, Q3e, Q3f, Q3g and Q3h in Table 1 denote the following substituents) .
Figure imgf000558_0001
82) The compounds represented by any of 59) to 81) wherein X is converted to SH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
83) The compounds represented by any of 59) to 81) wherein X is converted to NH2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof .
84) The compounds represented by any of 59) to 81) wherein X is converted to OAc, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
85) The thrombopoietin receptor activators represented by any of 1) to 84) . 86) Preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective, which contain the thrombopoietin receptor activators represented by 85) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient.
87) Platelet increasing agents containing the thrombopoietin receptor activators represented by 85) or the formula (1) , tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient..
88) Medicaments containing the compounds represented by
■ any of 1) to 84) or the formula (1) , tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof, as an active ingredient.
In the present invention, the compounds of the present invention represented by the formula (1) may be present in the form of tautomers or geometrical isomers which undergo endocyclic or exocyclic isomerization, mixtures of tautomers or geometric isomers or mixtures of thereof. When the compounds of the present invention have an asymmetric center, whether or not resulting from an isomerization, the compounds of the present invention may be in the form of resolved optical isomers or in the form of mixtures containing them in certain ratios.
For example, furan compounds, thiophene compounds and pyrrole compounds of the present invention may be present in the form of tetronic acid (4-hydroxy-2 (5H) - furanone) analogues, thiotetronic acid (4-hydroxy-2 (5H) - thiophenone) analogues and tetraminic acid (4-hydroxy-3- pyrrolin-2-one) analogues as shown below by the formulae (2) , (3) and (4) , mixtures thereof or mixtures of isomers thereof.
Figure imgf000561_0001
The compounds of the present invention represented by the formula (1) or pharmaceutically acceptable salts thereof may be in the form of arbitrary crystals or arbitrary hydrates, depending on the production conditions. The present invention covers these crystals, hydrates and mixtures. They may be in the form of solvates with organic solvents such as acetone, ethanol and tetrahydrofuran, and the present invention covers any of these forms. .
The compounds of the present invention represented by the formula (1) may be converted to pharmaceutically acceptable salts or may be liberated from the resulting salts, if necessary. The pharmaceutically acceptable salts of the present invention may be, for example, salts with alkali metals (such as lithium, sodium and potassium) , alkaline earth metals (such as magnesium and calcium) , ammonium, organic bases and amino acids. They may be salts with inorganic acids (such as hydrochloric acid, hydrobromic acid, phosphoric acid and sulfuric acid) and organic acids (such as acetic acid, citric acid, maleic acid, fumaric acid, benzenesulfonic acid and p- toluenesulfonic acid) .
The compounds which serve as prodrugs are derivatives of the present invention having chemically or metabolically degradable groups which give pharmacologically active compounds of- the present invention upon solvolysis or under physiological conditions in vivo. Methods for selecting or producing appropriate prodrugs are disclosed, for example, in Design of Prodrug (Elsevier, Amsterdam 1985) . In the present invention, when the compound has a hydroxyl group, acyloxy derivatives obtained by reacting the compound with appropriate acyl halides or appropriate acid anhydrides may, for example, be mentioned as prodrugs. Acyloxys particularly preferred as prodrugs include -OCOC2H5, -OCO(t-Bu), -OCOCi5H3I, -OCO (m-CO2Na-Ph) ,
-OCOCH2CH2CO2Na, -OCOCH(NH2)CH3, -OCOCH2N(CH3) 2 and the like. When the compound of the present •invention has an amino group, amide derivatives obtained by reacting the compound having an amino group with appropriate acid halides or appropriate mixed acid anhydrides may, for example, be mentioned as prodrugs. Amides particularly preferred as prodrugs include -NHCO(CH2) 2oOCH3,
-NHCOCH(NH2)CH3 and the like. When the compound of the present invention has a carboxyl group, carboxylic acid esters with aliphatic alcohols or carboxylic acid esters obtained by the reaction with an alcoholic free hydroxyl group of 1,2- or 1,3-digylcerides may, for example, be mentioned as prodrugs. Particularly preferred prodrugs are methyl esters and ethyl esters.
The preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective or platelet increasing agents which contain the thrombopoietin receptor activators of the present invention, tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof as an active ingredient may usually be administered as oral medicines such as tablets, capsules, powder, granules, pills, and syrup, as rectal medicines, percutaneous medicines or injections. The agents of the present invention may be administered as a single therapeutic agent or as a mixture with other therapeutic agents. Though they may be administered as they are, they are usually administered in the form of medical compositions. These pharmaceutical preparations can be obtained by adding pharmacologically and pharmaceutically acceptable additives by conventional methods. Namely, for oral medicines, ordinary excipients, lubricants, binders, disintegrants, humectants, plasticizers and coating agents may be used. Oral liquid preparations may be in the form of aqueous or oily suspensions, solutions, emulsions, syrups or elixirs or may be supplied as dry syrups to be mixed with water or other appropriate solvents before use. Such liquid preparations may contain ordinary additives such as suspending agents, perfumes, diluents and emulsifiers. In the case of rectal administration, they may be administered as suppositories. Suppositories may use an appropriate substance such as cacao butter, laurin tallow, Macrogol, glycerogelatin, Witepsol, sodium stearate and mixtures thereof as the base and may, if necessary, contain an emulsifier, a suspending agent, a preservative and the like. For injections, pharmaceutical ingredients such as distilled water for .injection, physiological saline, 5% glucose solution, propylene glycol and other solvents or solubilizing agents, a pH regulator, an isotonizing agent and a stabilizer may be used to form aqueous dosage forms or dosage forms which need dissolution before use.
The dose of the agents of the present invention for administration to human is usually about from 0.1 to 1000 mg/human/day in the case of oral drugs or rectal administration and about from 0.05 mg to 500 mg/human/day in the case of injections, though it depends on the age and conditions of the patient. The above-mentioned ranges are mere examples, and the dose should be determined from the conditions of the patient. The present invention is used when the use of compounds which have thrombopoietin receptor affinity and act as thrombopoietin receptor agonists are expected to improve pathological conditions. For example, hematological disorders accompanied by abnormal platelet count may be mentioned. Specifically, it is effective for therapy or prevention of human and mammalian diseases caused by abnormal megakaryopoiesis, especially those accompanied by thrombocytopenia. Examples of such diseases include thrombocytopenia accompanying chemotherapy or radiotherapy of cancer, thrombocytopenia accompanying antiviral therapy for diseases such as hepatitis C, thrombocytopenia caused by bone marrow transplantation, surgery and serious infections, or gastrointestinal bleeding, but such diseases are not restricted to those mentioned. Typical thrombocytopenias such as aplastic anemia., idiopathic thrombocytopenic purpura, myelodysplastic syndrome, hepatic disease, HIV infection and thrombopoietin deficiency are also targets of the agents of the present invention. The present invention may be used as a peripheral stem cell mobilizer, a megakaryoblastic or megakaryocytic leukemia cell differentiation inducer and a platelet increasing agent for platelet donors. In addition, potential applications include therapeutic angiogenesis based on differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, prevention and therapy of arteriosclerosis, myocardial infarction, unstable angina, peripheral artery occlusive disease, but there is no restriction.
The compounds represented by the formula (1) are prepared by the process represented by the formula (5) illustrated below.
Figure imgf000566_0001
(D
The. reaction of the compound (I) with a -NH2 compound (II) in a solvent, if necessary in the presence of a catalyst, under heating with stirring gives a desired compound or its precursor. The precursor may be, if necessary, hydrolyzed, deprotected, reduced or oxidized to a desired compound. The compounds of the present invention- usually can be purified by column chromatography, thin layer chromatography, high performance liquid chromatography (HPLC) or high performance liquid chromatography-mass spectrometry (LC- MS) and, if necessary, they may be obtained with high purity by recrystallization or washing with solvents.
For the syntheses of the intermediates (I) , syntheses of the following heterocyclic compounds may be referred to.
1) Pyrazole (the formula (6))
J. Chem. Soc. Perkin. Transl, p.81, (1985)
2) Isothiazole (the formula (7) ) Liebigs. Annalen. der. Chemie., 10, 1534-1546 (1979)
3) Isoxazole (the formula (8)) Synthesis, 10, 664-665 (1975)
4) Thiophene (the formula (9)) JP-A-48-026755 5) Furan (the formula (10) )
J. Org. Chem., 21, 1492-1509 (1956) and EP1253146
6) Pyrrole (the formula (H))
J. Heterocyclic Chem., 30, 1253 (1993) and Tetrahedron, " 50(26) , 7849-56 (1994) 7) Tetronic acid (4-hydroxy-2 (5H) -furanone) analogue (the formula (12) )
Synthesis, 7, 564-566 (1988) and Yakugaku Zasshi, 96(4) ,
536-543 (1976)
8) Tetraminic acid (4-hydroxy-3-pyrrolin-2-one) analogue (the formula (13) )
Synthesis, 2, 190-192 (1987) and Agric. Biol. Chem.,
43(8) , 1641-1646 (1979) (6)
Figure imgf000568_0001
(7)
Figure imgf000568_0002
(8)
Figure imgf000568_0003
(10)
Figure imgf000568_0004
Figure imgf000569_0001
(12)
Figure imgf000569_0002
Figure imgf000569_0003
(13)
Figure imgf000569_0004
For synthesis of the -NH2 compounds (II) , for example, when L3 = NH, the following may be referred to. 1) L4 = a bond, Y = O Synthetic Commun. , 28(7) , 1223-1231 (1998) , J. Chem. Soc . , 1225 (1948) and J. Chem. Soc, 2831 (1952)
2) L4 = NH, Y = O
J. Am. Chem. Soc, 46, 2813 (1924) and J. Chem. Soc, 2654 (1952)
3) L4 = NH, Y = S
Can. J. Chem., 35, 834 (1957)
4) L4 = NR22 or N- (heterocyclic group formed by R22 and R3) J. Org. Chem., 53, 2263 (1988)
5) L4 = CH2, Y = O
J. Org. Chem., 30, 2487 (1965)
6) L4 = 0, Y = O
Bull. Soc. Chim. BeIg., 68, 409, (1959)
7) L4 = S, Y = S
J. Med. Chem., 22, 853 (1979)
The compounds represented by the formula (1) wherein L3 is NR19, L4 is NH, and Y is O or S are prepared by the process represented by the formula (14) illustrated below.
Figure imgf000570_0001
(III) The compounds represented by the formula (1) wherein L3 is NR19, L4 is a bond, and Y is O or S are prepared by the process represented by the formula (15) illustrated below.
Figure imgf000571_0001
The reaction of the compound (I) with a NH2 compound (IV) in a solvent, if necessary in the presence of a catalyst, under heating with stirring gives the compound (III) as the desired product.
Figure imgf000571_0002
The compounds represented by the formula (1) wherein L3 is NR19, L4 is NR22 or forms a heterocyclic group together with R3 are prepared by the process represented by the formula (16) illustrated below.
Figure imgf000572_0001
EXAMPLES
Now, the present invention will be described in further detail with reference to Reference Synthetic Examples, Synthetic Examples, Assay Examples and Formulation Examples. However, it should be understood that the present invention is by no means restricted by these specific Examples. The 1H-NMR analysis was carried out at 300 MHz, and
LC/MS was measured under the following conditions. LC/MS condition 1
Column: Waters SunFire C18 (3.5 μm, 4.6x30 mm) Eluent: acetonitrile/0.1% aqueous formic acid (10/90 → 60/40)
LC/MS conditions 2
Column: Waters SunFire C18 (3.5 μm, 4.6x30 mm)
Eluent: acetonitrile/O.1% aqueous formic acid (10/90 →
85/15) LC/MS conditions 3
Column: Waters SunFire C18 (3.5 μm, 4.6x30 mm)
Eluent: acetonitrile/O .1% aqueous formic acid (20/80 → 100/0)
LC/MS conditions 4
Column: Waters Xterra MSC18 (5 μm, 4.6x50 mm)
Eluent : acetonitrile/0.1% aqueous formic acid (10/90 → 60/40)
LC/MS conditions 5
Column: Waters Xterra MSC18 (3.5 μm, 2.1x20 mm)
Eluent: acetonitrile/O .2% aqueous formic acid (20/80 →
90/10) REFERENCE SYNTHETIC EXAMPLE 1
Synthesis of 2- (3 , 4-dichlorophenyl) -4- (1- hydorazonoethyl) thiophen-3-ol
To a suspension of 2- (3 , 4-dichlorophenyl) -3 -hydroxy-
4-methylcarbonylthiophene (300 mg, 1.05 mmol) (prepared by the method disclosed in WO2004/108683) in isopropanol
(20 mL) was added hydrazine monohydrate (61 μL, 1.25 mmol) . The reaction mixture was refluxed for 1.5 hours, stirred at room temperature for 0.5 hour and at 00C for 1 hour. The precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product (yield 100%) .
Morphology: a pale yellow solid
1H-NMR (DMSOd6) δ (ppm) : 2.10 (s, 3H) , 6.63 (br s, 2H) ,
7.58(s, 2H) , 7.61 (s, IH), 7.98 (s, IH) , 12.88 (s,' IH) . LC/MS: condition 4, retention time 4.95 (min)
LC/MS (ESI+)m/z; 301, 303 [M+l] +
LC/MS (ESI")m/z; 299, 301 [M-I]" REFERENCE SYNTHETIC EXAMPLE 2
Synthesis of methyl l-hydrazinothiocarbonylpiperidine-4- carboxylate
To a solution of methyl isonipecotate (1.0 g, 7.0 mmol) in tetrahydrofuran was added thiocarbonyl diimidazole (1.24 g, 6.98 mmol) at room temperature, and the reaction solution was stirred at room temperature for
1.5 hours and then stirred with hydrazine monohydrate
(700 mg, 14.0 mmol) for 4 hours. After addition of saturated aqueous sodium chloride, the reaction solution was extracted with ethyl acetate and chloroform, and the extract was dried over anhydrous magnesium sulfate and concentrated to give the desired product (yield 114%) .
Morphology: pale yellow solid LC/MS: condition 5, retention time 0.52 (min)
LC/MS (ESI+)m/z; 218, [M+l] +
REFERENCE SYNTHETIC EXAMPLE 3
Synthesis of ethyl l-hydrazinothiocarbonylpiperidine-3- carboxylate Synthesis was carried out in the same manner as in
Reference Synthetic Example 2 by using ethyl nipecotate.
REFERENCE SYNTHETIC EXAMPLE 4
Synthesis of l-hydrazinothiocarbonylpiperidine-4- carboxylic acid diethylamide Synthesis was carried out in the same manner as in
Reference Synthetic Example 2 by using isonipecotic acid diethylamide. REFERENCE SYNTHETIC EXAMPLE 5 Synthesis of l-hydrazinothiocarbonylpiperidin-4-ol
A solution of methyl hydrazinecarbothioate (1.0 g, 8.2 mmol) and piperidin-4-ol (1.24 g, 12.3 mmol) in ethanol (7 mL) was refluxed with heating at 90°C for 2 days. After addition of ethyl acetate, the reaction solution was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the crude desired product. The crude product was used directly for the next reaction. REFERENCE SYNTHETIC EXAMPLE 6 Synthesis of l-hydrazinothiocarbonylpiperidin-3-ol
Synthesis was carried out in the same manner as in Reference Synthetic Example 5 by using piperidin-3-ol . REFERENCE SYNTHETIC EXAMPLE 7
Synthesis of l-hydrazinothiocarbonylpiperidine-4-methanol
Synthesis was carried out in the same manner as in Reference Synthetic Example 5 by using 4- piperidinemethanol . REFERENCE SYNTHETIC EXAMPLE 8
Synthesis of methyl 2- [4- (tert-butoxycarbonyl)piperazin- 1-yl] acetate
A solution of 1- (tert-butoxycarbonyl)piperazine (1.38 g, 7.41 mmol) in acetonitrile (10 mL) was stirred with triethylamine (2.07 mL, 14.8 mmol) and methyl 2- bromoacetate (1.02 mL, 11.1 mmol) at room temperature for 4 hours and then filtered. The filtrate was concentrated, and after addition of saturated aqueous ammonium chloride, extracted with ethyl acetate. The organic phase was washed with saturated aqueous ammonium chloride and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the desired product (yield 83%) . Morphology: pale yellow liquid
1H-NMR (CDCl3) δ: 1.46 (s, 9H), 2.53 (t, J=5.1 Hz, 4H) , 3.24(s, 2H) , 3.49(t, J=5.1 Hz, 4H) , 3.73(s, 3H) REFERENCE SYNTHETIC EXAMPLE 9
Synthesis of ethyl 3- [4- (tert-butoxycarbonyl)piperazin-l- yl]propionate
Synthesis was carried out in the same manner as in Reference Synthetic Example 8 by using ethyl 3- bromopropionate.
Morphology: colorless mixture of solid and liquid 1H-NMR (CDCl3)O: 1.26 (t, J=7.2 Hz, 3H) , 1.46 (s, 9H), 2.41(t, J=4.8 Hz, 4H) , 2.50(t, J=7.2 Hz, 2H), 2.71(t, J=7.2 Hz, 2H), 3.42(t, J=4.8 Hz, 4H) , 4.14 (q, J=7.2 Hz, 2H)
REFERENCE SYNTHETIC EXAMPLE 10
Synthesis of methyl 2- [4-hydrazinothiocarbonylpiperazin-
1-yl] acetate
A solution of methyl 2- [4- (tert- butoxycarbonyl)piperazin-1-yl] acetate prepared in Reference Synthetic Example 8 in dioxane (9 mL) was stirred with 4N hydrogen chloride/dioxane solution (3.91 mL, 15.7 mmol) at 80°C for 1.5 hours. The solution was allowed to cool and filtered. Tetrahydrofuran and triethylamine (0.88 mL, 6.3 mmol) were added to the filter cake, and the procedure in Reference Synthetic Example 2 was followed using the resulting solution. The resulting crude product was used directly for the next reaction.
Morphology: pale yellow solid REFERENCE SYNTHETIC EXAMPLE 11 Synthesis of ethyl 3- [4-hydrazinothiocarbonylpiperazin-l- yl]propionate
Synthesis was carried out in the same manner as in Reference Synthetic Example 10 by using ethyl 3- [4- (tert- butoxycarbonyl)piperazin-1-yl]propionate prepared in Reference Synthetic Example 9. Morphology: pale yellow solid SYNTHETIC EXAMPLE 1
Synthesis of methyl 1-{l- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylate
To a dimethylformamide solution (600 μL) of 2- (3,4- dichlorophenyl) -3-hydroxy-4-methylcarbonylthiophene (30 mg, 0.10 mmol) and methyl 1-hydrazinothiocarbonyl- piperidine-4-carboxylate (46 mg, 0.20 mmol) prepared in Reference Synthetic Example 2, concentrated hydrochloric acid (9 μL, 0.1 mmol) was added at room temperature, and the resulting solution was stirred at room temperature for 8 hours, then mixed with water and extracted with ethyl acetate. The extract was washed with 1 M hydrochloric acid and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate = 1/1) and recrystallized from chloroform to give the desired product (yield 55%) . Morphology: white solid 1H-NMR (DMSOd6) δ: 1.55-1.75 (m, 2H) , 1.85-1.95 (m, 2H) , 2.38 (s, 3H) , 2.7-2.8(m, IH), 3.15-3.30 (m, 2H) , 3.48 (s, 3H), 4.58 (d, J = 13.5Hz, 2H) , 7.64(d, J = 8.4 Hz, IH), 7.71(d, J = 8.4, 2.1Hz, IH) , 8.00(s, IH), 8.03(d, J = 2.1 Hz, IH), 12.4 (s, IH) LC/MS: condition 5, retention time 5.19 (min) LC/MS (ESI+)m/z; 486, 488 [M+l] + LC/MS (ESI")m/z; 484, 486 [M-I]" SYNTHETIC EXAMPLE 2 Synthesis of 1-{1- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylic. acid
To a suspension of methyl l-{l-[5-(3,4- dichlorophenyl) -4-hydroxythiophen-3-yl] -ethylidene- hydrazinocarbonyl}-piperidine-4-carboxylate (10 mg, 0.021 mmol) in methanol (300 μL) , 1 M aqueous sodium hydroxide (250 μL) was added at room temperature, and the suspension was stirred at room temperature for 7 hours. After the reaction, 1 M hydrochloric acid (250 μL) was added, and the resulting crystals were collected by filtration as the desired product (yield 71%) .
Morphology: gray solid LC/MS: condition 5, retention time 4.87 (min)
LC/MS (ESI+)m/z; 472, 474 [M+1] +
LC/MS (ESI")m/z; 470, 472 [M-I]"
SYNTHETIC EXAMPLE 3
Synthesis of methyl 2- [ (2- {1- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene}- hydrazinocarbonothioyl) amino] acetate
A solution of 2- (3, 4-dichlorophenyl) -4- (1- hydrazonoethyl) thiophen-3-ol (30 mg, 0.10 mmol) prepared in Reference Synthetic Example 1 and methyl 2- isothiocyanatoacetate (20 mg, 0.15 mmol) in dimethylformamide (300 μL) was stirred at room temperature, 400C and 500C for 2 hours, respectively.
After addition of methanol-water, the solution was stirred at room temperature for 0.5 hour, and the resulting crystals were collected by filtration as the desired product (yield 72%) .
Morphology: white solid
LC/MS: condition 5, retention time 4.95 (min)
LC/MS (ESI+)m/z; 432, 434 [M+l] + LC/MS (ESI")m/z; 430, 432 [M-I]"
SYNTHETIC EXAMPLE 4
Synthesis of 2- [ (2-{l- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -etylidene}- hydrazinocarbonothioyl) amino] acetic acid
Synthesis was carried out in the same manner as in
Synthetic Example 2 using methyl 2- [ (2-{l- [5- (3,4- dichlorophenyl) -4-hydroxythiophen-3-yl] -ethylidene}- hydrazinocarbonothioyl) amino] acetate prepared in
Synthetic Example 3 (yield 39%) .
Morphology: white solid
LC/MS: condition 5, retention time 4.65 (min) LC/MS (ESI+)m/z; 418, 420 [M+l] +
LC/MS (ESI")m/z; 416, 418 [M-I]"
SYNTHETIC EXAMPLE 5
Synthesis of methyl 3- [ (2-{1- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene}- hydrazinocarbonothioyl) amino]propionate
Synthesis was carried out in the same manner as in
Synthetic Example 3 by using methyl 3- isothiocyanatopropionate (yield 78%) .
Morphology: white solid LC/MS: condition 5, retention time 5.03' (min)
LC/MS (ESI+)m/z; 446 [M+l]+
LC/MS (ESI")m/z; 444, 446 [M-I]"
SYNTHETIC EXAMPLE 6
Synthesis of 3- [ (2-{l- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene}- hydrazinocarbonothioyl) amino]propionic acid
Synthesis was carried out in the same manner as in Synthetic Example 2 by using methyl 3-[(2-{l-[5-(3,4- dichlorophenyl) -4-hydroxythiophen-3-yl] -ethylidene}- hydrazinocarbonothioyl) amino] propionate prepared in
Synthetic Example 5 (yield 41%) . Morphology: white solid
LC/MS: condition 5, retention time 4.74 (min)
LC/MS (ESI+)m/z; 432, 434 [M+l] +
LC/MS (ESI")m/z; 430, 432 [M-I]"
SYNTHETIC EXAMPLE 7 Synthesis of 1- (2-{1- [5- (3, 4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene}- hydrazinocarbonothioyl) amino-2-methoxyethane
Synthesis was carried out in the same manner as in
Synthetic Example 3 by using 2-methoxyethyl isothiocyanate (yield 43%) .
Morphology: pale yellow solid
LC/MS: condition 5, retention time 5.05 (min)
LC/MS (ESI+)m/z; 418, 420 [M+l] +
LC/MS (ESI")m/z; 416, 418 [M-I]" SYNTHETIC EXAMPLE 8
Synthesis of methyl 1-{.1- [5- (4-bromophenyl) -4-hydroxy- thiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylate
Synthesis was carried out in the same manner as in Synthetic Example 1 by using 1- [5- (4-bromophenyl) -4- hydroxy-thiophen-3-yl] -ethanone (prepared by the method disclosed in W02004/108683) and methyl 1- hydrazinothiocarbonyl-piperidine-4-carboxylate prepared in Reference Synthetic Example 2 (yield 64%) .
Morphology: pale yellow solid
LC/MS: condition 2, retention time 3.74 (min) LC/MS (ESI+)m/z; 496, 498 [M+l] +
LC/MS (ESI")m/z; 494, 496 [M-I]'
SYNTHETIC EXAMPLE 9
Synthesis of 1- {1- [5- (4-bromophenyl) -4-hydroxy-thiophen-
3-yl] -ethylidene-hydrazinothiocarbonyl} -piperidin-4- carboxylic acid
Synthesis was carried out in the same manner as in
Synthetic Example 2 by using methyl l-{l-[5-(4- bromophenyl) -4-hydroxy~thiophen-3-yl] -ethylidene- hydrazinothiocarbonyl} -piperidine-4-carboxylate prepared in Synthetic Example 8 (yield 87%) .
Morphology: pale yellow solid
LC/MS: condition 2, retention time 3.45 (min)
LC/MS (ESI+)m/z; 482, 484 [M+l]+
LC/MS (ESI')m/z; 480, 482 [M-I]" SYNTHETIC EXAMPLE 10
Synthesis of 1- {1- [4-hydroxy-5- (4-trifluoromethylphenyl) - thiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylic acid
Methyl l-{l- [4-hydroxy-5- (4-trifluoromethylphenyl) - thiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylate
Synthesis was carried out in the same manner as in Synthetic Example 1 using 1- [4-hydroxy-5- (4- trifluoromethylphenyl) -thiophen-3-yl] ethanone (prepared by the method disclosed in W02004/108683) and methyl 1- hydrazinothiocarbonylpiperidine-4-carboxylate prepared in Reference Synthetic Example 2 (yield 36%) .
Morphology: pale yellow solid
LC/MS: condition 1, retention time 4.54 (min)
LC/MS (ESI+)m/z; 486 [M+l] +
LC/MS (ESr)m/z; 484 [M-I]" l-{l- [4-Hydroxy-5- (4-trifluoromethylphenyl) -thiophen-3- yl] -ethylidene-hydrazinothiocarbonyl}-piperidine-4- carboxylic acid
Synthesis was carried out in the same manner as in
Synthetic Example 2 using methyl 1-{1- [4-hydroxy-5- (4- trifluoromethylphenyl) -thiophen-3-yl] -ethylidene- hydrazinothiocarbonyl}-piperidine-4-carboxylate prepared above (yield 58%) .
Morphology: white solid
LC/MS: condition 5, retention time 4.88 (min) LC/MS (ESI+)m/z; 472 [M+l] +
LC/MS (ESI")m/z; 470 [M-I]"
SYNTHETIC EXAMPLE 11
Synthesis of 1-{1- [5- (4-trifluoromethoxyphenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl} - piperidine-4-carboxylic acid
Methyl l-{l- [5- (4-trifluoromethoxyphenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylate
Synthesis was carried out in the same manner as in
Synthetic Example 1 using 1- [5- (4- trifluoromethoxyphenyl) -4-hydroxythiophen-3-yl] ethanone (prepared by the method disclosed in WO2004/108683) and methyl l-hydrazinothiocarbonylpiperidine-4-carboxylate prepared in Reference Synthetic Example 2 (yield 53%)..
Morphology: pale yellow solid
LC/MS: condition 2, retention time 3.75 (min) LC/MS (ESI+)m/z; 502 [M+l]+
LC/MS (ESI")m/z; 500 [M-I]" l~{l- [5- (4-Trifluoromethoxyphenyl) -4~hydroxythiophen-3- yl] -ethylidene-hydrazinothiocarbonyl}-piperidine-4- carboxylic acid . Synthesis was carried out in the same manner as in
Synthetic Example 2 using methyl l-{l-[5-(4- trifluoromethoxyphenyl) -4-hydroxythiophen-3-yl] - ethylidene-hydrazinothiocarbonyl} -piperidine-4- carboxylate prepared above (yield 52%) . Morphology: pale yellow solid
LC/MS: condition 2, retention time 3.49 (min)
LC/MS (ESI+)m/z; 488 [M+l] +
LC/MS (ESI")m/z; 486 [M-I]"
SYNTHETIC EXAMPLE 12 Synthesis of l- { l - [5 - (4 -chlorophenyl ) -4 -hydroxy- thiophen-
3 -yl] -ethilidene-hydrazinothiocarbonyl } -piperidine-4 - carboxylic acid Methyl l-{l- [5- (4-chlorophenyl) -4-hydroxy-thiophen-3-yl] - ethilidene-hydrazinothiocarbonyl} -piperidine-4- carboxylate
Synthesis was carried out in the same manner as in Synthetic Example 1 using 1- [5- (4-chlorophenyl) -4- hydroxy-thiophen-3-yl] ethanone (prepared by the method disclosed in WO2004/108683) and methyl 1- hydrazinothiocarbonylpiperidine-4-carboxylate prepared in
Reference Synthetic Example 2 (yield 41%) . Morphology: pale yellow solid
LC/MS: condition 1, retention time 4.50 (min)
LC/MS (ESI+)m/z; 452, 454 [M+l] +
LC/MS (ESI")m/z; 450, 452 [M-I]" l-{l- [5- (4-Chlorophenyl) -4-hydroxy-thiophen-3-yl] - ethilidene-hydrazinothiocarbonyl } -piperidine-4-carboxylic acid
Synthesis was carried out in the same manner as in
Synthetic Example 2 using methyl l-{l-[5-(4- chlorophenyl) -4-hydroxy-thiophen-3-yl] -ethilidene- hydrazinothiocarbonyl} -piperidine-4-carboxylate prepared above (yield 92%) .
Morphology: yellow solid
LC/MS: condition 1, retention time 4.14 (min)
LC/MS (ESI+)m/z; 438, 440 [M+l]+ LC/MS (ESI")m/z; 436, 438 [M-I]"
SYNTHETIC EXAMPLE 13
Synthesis of 1-{l- [5- (3,4-dimethylphenyl) -4-hydroxy- thiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylic acid
Methyl l-{l- [5- (3,4-dimethylphenyl) -4-hydroxy-thiophen-3- yl] -ethylidene-hydrazinothiocarbonyl}-piperidine-4- carboxylate
Synthesis was carried out in the same manner as in
Synthetic Example .1 using 1- [5- (3,4-dimethylphenyl) -4- hydroxy-thiophn-3-yl] -ethanone (prepared by the method disclosed in WO2004/108683) and methyl 1- hydrazinothiocarbonylpiperidine-4-carboxylate prepared in
Reference Synthetic Example 2 (yield 28%) .
Morphology: pale yellow solid
LC/MS: condition 2, retention time 3.69 (min)
LC/MS (ESI+)m/z;. 446 [MH-I] + LC/MS (ESI")m/z; 444 [M-I]"
1- {l- [5- (3,4-Dimethylphenyl) -4-hydroxy-thiophen-3-yl] - ethylidene-hydrazinothiocarbonyl} -piperidine-4-carboxylic acid
Synthesis was carried out in the same manner as in Synthetic Example 2 using methyl 1- {l- [5- (3 , 4- dimethylphenyl ) -4 -hydroxy- thiophen-3-yl] - ethyl idene- hydrazinothiocarbonyl} -piperidine- 4 -carboxylate prepared above (yield 100%) .
Morphology: pale brown solid LC/MS: condition 2, retention time 3.38 (min)
LC/MS (ESI+) m/z; 431.78 [M+l]+
LC/MS (ESI")m/z; 429.89 [M-I]" SYNTHETIC EXAMPLE 14
Synthesis of 1- {1- [5- (4-t-butylphenyl) -4-hydroxy- thiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylic acid Methyl 1- {1- [5- (4-t-butylphenyl) -4-hydroxy-thiophen-3- yl] -ethylidene-hydrazinothiocarbonyl}-piperidine-4- carboxylate
Synthesis was carried out in the same manner as in
Synthetic Example 1 using 2- (4-t-butylphenyl) -3-hydroxy- 4-methylcarbonylthiophene and methyl 1- hydrazinothiocarbonylpiperidine-4-carboxylate prepared in
Reference Synthetic Example 2 (yield 57%) .
Morphology: pale brown solid
LC/MS: condition 2, retention time 3.87 (min) LC/MS (ESI+)m/z; 474 [M+l] +
LC/MS (ESI")m/z; 472 [M-I]" l-{l- [5- (4-t-Butylphenyl) -4-hydroxy-thiophen-3-yl] - ethylidene-hydrazinothiocarbonyl} -piperidine-4-carboxylic acid Synthesis was carried out in the same manner as in
Synthetic Example 2 using methyl 1-{l- [5- (4-t- butylphenyl) -4-hydroxy-thiophen-3-yl] -ethylidene- hydrazinothiocarbonyl}-piperidine-4-carboxylate prepared above (yield 89%) . Morphology: dark brown solid
1H-NMR (ppm in DMSO-d6) δ 1.22 (s, 9H), 1.57-1.61 (m, 2H) , 1.88-1.92 (m, 2H), 2.36 (s, 3H) , 4.53-4.58 (m, 2H) , 7.41 (d, 2H, J = 8.5 Hz) ,
7.67 (d, 2H, J = 8.5 Hz) , 7.85 (s, IH) , 10.25 (brs, IH) ,
11.98 (brs, IH)
SYNTHETIC EXAMPLE 15 Synthesis of 1-{l- [5- (3-chlorophenyl) -4-hydroxythiophen-
3-yl] -ethylidene-hydrazinothiocarbonyl}-piperidine-4- carboxylic acid
Methyl l-{l- [5- (3-Chlorophenyl) -4-hydroxythiophen-3-yl] - ethylidene-hydrazinothiocarbonyl}-piperidine-4- carboxylate
Synthesis was carried out in the same manner as in
Synthetic Example 1 using 1- [5- (3-chlorophenyl) -4- hydroxythiopen-3-yl] ethanone (prepared by the method disclosed in WO2004/108683) and methyl 1- hydrazinothiocarbonylpiperidine-4-carboxylate prepared in
Reference Synthetic Example 2 (yield 63%) .
Morphology: pale yellow solid
LC/MS: condition 2, retention time 3.67 (min)
LC/MS (ESI+)m/z; 452, 454 [M+l] + LC/MS (ESI")m/z; 450, 452 [M-I]" l-{l- [5- (3-Chlorophenyl) -4-hydroxythiophen-3-yl] - ethylidene-hydrazinothiocarbonyl}-piperidine-4-carboxylic acid
Synthesis was carried out in the same manner as in Synthetic Example 2 using methyl l-{l-[5-(3- chlorophenyl) -4-hydroxythiophen-3-yl] -ethylidene- hydrazinothiocarbonyl}-piperidine-4-carboxylate prepared above (yield 71%) .
Morphology: pale yellow solid
LC/MS: condition 2, retention time 3.38 (min)
LC/MS (ESI+)m/z; 438, 440 [M+l]+ LC/MS (ESI")m/z; 436, 438 [M-I]'
SYNTHETIC EXAMPLE 16
Synthesis of 1-{l- [4-hydroxy-l-methyl-5- (4- trifluoromethylphenyl) -lH-pyrazol-3-yl] -ethylidene- hydrazinothiocarbonyl} -piperidine-4-carboxylic acid Methyl 1-{1- [4-hydroxy-l-methyl-5- (4- trifluoromethylphenyl) -lH-pyrazol-3-yl] -ethylidene- hydrazinothiocarbonyl}-piperidine-4-carboxylate
Synthesis was carried out in the same manner as in
Synthetic Example 1 using 1- [4-hydroxy-l-methyl-5- (4- trifluoromethylphenyl) -lH-pyrazol-3-yl] ethanone (prepared by the method disclosed in WO2004/108683) and methyl 1- hydrazinothiocarbonylpiperidine-4-carboxylate prepared in
Reference Synthetic Example 2 (yield 70%) .
Morphology: yellow solid LC/MS: condition 1, retention time 4.12 (min)
LC/MS (ESI+)m/z; 484 [M+.l] +
LC/MS (ESI~)m/z; 482 [M-I]" l-{l- [4-Hydroxy-l-methyl-5- (4-trifluoromethylphenyl) -IH- pyrazol-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylic acid
Synthesis was carried out in the same manner as in
Synthetic Example 2 using methyl 1-{l- [4-hydroxy-l- methyl-5- (4-trifluoromethylphenyl) -lH-pyrazol-3-yl] - ethylidene-hydrazinothiocarbonyl}-piperidine-4- carboxylate prepared above (yield 85%) .
Morphology: pale yellow solid LC/MS: condition 1, retention time 3.69 (min)
LC/MS (ESI+)m/z; 470 [M+l] +
LC/MS (ESI")m/z; 468 [M-I]"
SYNTHETIC EXAMPLE 17
Synthesis of 1-{l- [5- (3,4-dichlorophenyl) -4-hydroxy-1- methyl-lH-pyrazol-3-yl] -ethylidene- hydrazinothiocarbonyl} -piperidine-4-carboxylic acid
Methyl l-{l- [5- (3,4-dichlorophenyl) -4-hydroxy-l-methyl- lH-pyrazol-3-yl] -ethylidene-hydrazinothiocarbonyl} - piperidine-4-carboxylate Synthesis was carried out in the same manner as in
Synthetic Example 1 using 1- [5- (3,4-dichlorophenyl) -4- hydroxy-1-methyl-lH-pyrazol-3-yl] ethanone (prepared by the method disclosed in WO2004/108683) and methyl 1- hydrazinothiocarbonylpiperidine-4-carboxylate prepared in Reference Synthetic Example 2 (yield 61%) .
Morphology: pale pink solid
LC/MS: condition 1, retention time 4.30 (min)
LC/MS (ESI+)m/z; 484, 486 [M+l] +
LC/MS (ESI~)m/z; 482, 484 [M-I]" l-{l- [5- (3,4-Dichlorophenyl) -4-hydroxy-1-methyl-IH- pyrazol-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylic acid Synthesis was carried out in the same manner as in
Synthetic Example 2 using methyl 1- {1- [5- (3,4- dichlorophenyl) -4-hydroxy-l-methyl-lH-pyrazol-3-yl] - ethylidene-hydrazinothiocarbonyl} -piperidine-4- carboxylate prepared above (yield 89%) .
Morphology: pale yellow solid
LC/MS: condition 1, retention time 3.79 (min)
LC/MS (ESI+)m/z; 470, 472 [M+l] +
LC/MS (ESI")m/z; 468, 470 [M-I]" SYNTHETIC EXAMPLE 18
Synthesis of 1-{1- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl} - piperidine-3-carboxylic acid
Ethyl l-{l- [5- (3,4-dichlorophenyl) -4-hydroxythiophen-3- yl] -ethylidene-hydrazinothiocarbonyl}-piperidine-3- carboxylate
Synthesis was carried out in the same manner as in
Synthetic Example 1 using ethyl 1- hydrazionothiocarbonylpiperidine-3-carboxylate prepared in Reference Synthetic Example 3 (yield 52%) .
Morphology: white solid l-{l- [5- (3,4-dichlorophenyl) -4-hydroxythiophen-3-yl] - ethylidene-hydrazinothiocarbonyl}-piperidine-3-carboxylic acid • Synthesis was carried out in the same manner as in
Synthetic Example 2 using ethyl 1-{l- [5- (3,4- dichlorophenyl) -4-hydroxythiophen-3-yl]-ethylidene- hydrazinothiocarbonyl}-piperidine-3-carboxylate prepared above (yield 67%) .
Morphology : white solid
LC/MS : condition 5 , retention time 4 . 98 (min) LC/MS (ESI+ ) m/ z ; 472 [M+l] +
LC/MS (ESI" ) m/ z ; 470 [M- I] "
SYNTHETIC EXAMPLE 19
Synthesis of 1-{1- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-carboxylic acid diethylamide
Synthesis was carried out in the same manner as in
Synthetic Example 1 using 1- hydrazionothiocarbonylpiperidine-4-carboxylic acid diethylamide prepared in Reference Synthetic Example 4 (yield 23%) .
Morphology: white solid
LC/MS: condition 5, retention time 3.80 (min)
LC/MS (ESI+)m/z; 527 [M+l] +
SYNTHETIC EXAMPLE 20 Synthesis of 1-{l- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidin-4-ol
Synthesis was carried out in the same manner as in
Synthetic Example 1 using 1- hydrazinothiocarbonylpiperidin-4-ol prepared in Reference
Synthetic Example 5 (yield 21%) .
Morphology: white solid LC/MS: condition 5, retention time 4.88 (min)
LC/MS (ESI+)m/z; 444 [M+l]+
LC/MS (ESI")m/z; 442 [M-I]"
SYNTHETIC EXAMPLE 21 Synthesis of 1-{1- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidin-3-ol
Synthesis was carried out in the same manner as in
Synthetic Example 1 using crude 1- hydrazinothiocarbonylpiperidin-3-ol prepared in Reference
Synthetic Example 6 (yield 53%) .
Morphology: pale yellow solid
LC/MS: condition 5, retention time 4.92 (min)
LC/MS (ESI+)m/z; 444 [M+l] + LC/MS (ESI")m/z; 442 [M-I]"
SYNTHETIC EXAMPLE 22
Synthesis of 1-{1- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperidine-4-methanol Synthesis was carried out in the same manner as in
Synthetic Example 1 using crude 1- hydrazinothiocarbonylpiperidine-4-methanol prepared in
Reference Synthetic Example 7 (yield 22%) .
Morphology: white solid LC/MS: condition 5, retention time 4.98 (min)
LC/MS (ESI+)m/z; 458 [M+1] +
LC/MS (ESI")m/z; 456 [M-I]" SYNTHETIC EXAMPLE 23 Synthesis of
1- (2-{l- [5- (3,4-dichlorophenyl) -4-hydroxythiophen-3-ylj - ethylidene}-hydrazinocarbonothioyl) amino-3-methoxypropane Synthesis was carried out in the same manner as in Synthetic Example 3 using 3-methoxypropyl isothiocyanate (yield 19%) .
Morphology: pale yellow solid LC/MS: condition 5, retention time 5.22 (min) LC/MS (ESI+)m/z; 432 [M+l] + LC/MS (ESI")m/z; 430 [M-I]" SYNTHETIC EXAMPLE 24
Synthesis of 1-{l- [5- (4-bromophenyl) -4-hydroxythiophen-3- yl] -ethylidene-hydrazinothiocarbonyl}-piperidine-4- carboxylic acid 4-picolylamide
To l-{l- [5- (4-bromophenyl) -4-hydroxythiophen-3-yl] - ethylidene-hydrazinothiocarbonyl}-piperidine-4-carboxylic acid (84 mg, 0.17 mmol) prepared in Synthetic Example 9, dimethylformamide (2 mL) and 1- [3- (dimethylamino)propyl] ~ 3-ethylcarbodiimide hydrochloride (66 mg, 0.25 mmol) and HOBt (47 mg, 0.25 mmol). were added, and then dimethylformamide (2.5 mL) and diisopropylethylamine (91 μL, 0.52 mmol) were added. The resulting solution was stirred at room temperature for 1 hour and then stirred with a dimethylformamide solution (1.5 mL) of 4- picolylamine (47 mg, 0.43 mmol) for 24 hours. After addition of water, the reaction mixture- was filtered, and the filter cake was dried and washed with isopropyl alcohol repeatedly to give the desired product (yield
34%) .
Morphology: pale yellow solid LC/MS : condition 1, retention time 3.05 (min)
LC/MS (ESI+)m/z; 572, 574 [M+l] +
LC/MS (ESI")m/z; 570, 572 [M-I]"
SYNTHETIC EXAMPLE 25
Synthesis of 1-{l- [5- (4-bromophenyl) -4-hydroxythiophen-3- yl] -ethylidene-hydrazinothiocarbonyl} -piperidine-4- carboxylic acid 2-picolylamide
Synthesis was carried out in the same manner as in
Synthetic Example 24 using 2-picolylamine (yield 22%) .
Morphology: pal.e yellow solid LC/MS: condition 1, retention time 3.62 (min)
LC/MS (ESI+)m/z; 572, 574 [M+l] +
LC/MS (ESI")m/z; 570, 572 [M-I]"
SYNTHETIC EXAMPLE 26
Synthesis of 1-{l- [5- (4-bromophenyl) -4-hydroxythiophen-3- yl] -ethylidene-hydrazinothiocarbonyl} -piperidine-4- carboxylic acid 3-picol.ylamide
Synthesis was carried out in the same manner as in
Synthetic Example 24 using 3-picolylamine (yield 4%) .
Morphology: yellow solid LC/MS: condition 1, retention time 3.25 (min)
LC/MS (ESI+)m/z,• 572, 574 [M+l] +
LC/MS (ESI")m/z; 570, 572 [M-I]" SYNTHETIC EXAMPLE 27
Synthesis of 2- [4-{l- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperazin-1-yl] acetic acid Methyl 2- [4-{l- [5- (3,4-dichlorophenyl) -4-hydroxythiophen- 3-yl] -ethylidene-hydrazinothiocarbonyl} -piperazin-1- yl] acetate
Methyl 2- [4-hydrazinothiocarbonylpiperazin-l- yl] acetate (356 mg, 1.52 mmol) prepared in Reference Synthetic Example 10 and 2- (3,4-dichlorophenyl) -3- hydroxy-4-methylcarbonylthiophene (147 mg, 0.512 mmol) were stirred with dimethylformamide (4 mL) and concentrated hydrochloric acid (42.6 μL, 1.52 mmol) at room temperature to 600C for 5 days. After addition of water, the reaction mixture was filtered, and the filter cake was dried. The filter cake was mixed with chloroform and filtered, and the filtrate was concentrated then mixed with chloroform, isopropyl alcohol and n-hexane and filtered. The filter cake was dried to give the crude desired product (yield 18%) . The crude product was used directly for the next reaction.
LC/MS: condition 1, retention time 3.97 (min)
LC/MS (ESI+)m/z; 501, 503 [M+l]+
LC/MS (ESI")m/z; 499, 501 [M-I]" Synthesis of 2- [4-{l- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperazin-1-yl] acetic acid The procedure in Synthetic Example 2 was followed using methyl 2- [4- {l- [5- (3,4-dichlorophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperazin-1-yl] acetate to give the crude desired product. The crude product was washed with chloroform to give the desired product (yield 11%) .
Morphology: pale yellow solid
LC/MS: condition 1, retention time 3.60 (min)
LC/MS (ESI+)m/z; 487, 489 [M+l]+ LC/MS (ESI')m/z; 485, 487 [M-I]"
SYNTHETIC EXAMPLE 28
Synthesis of 2- [4-{l- [5- (4-bromophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperazin-1-yl] acetic acid Methyl 2- [4-{l- [5- (4-bromophenyl) -4-hydroxyth.ioph.en-3- yl] -ethylidene-hydrazinothiocarbonyl}-piperazin-1- yl] acetate
The condensation procedure in Synthetic Example 27 was followed using 2- (4-bromophenyl) ~3-hydroxy-4- methylcarbonylthiophene to give the crude desired product
(yield 57%) . The crude product was used directly for the next reaction.
Morphology: pale yellow solid
2- [4-{l- [5- (4-bromophenyl) -4-hydroxythiophen-3-yl] - ethylidene-hydrazinothiocarbonyl} -piperazin-1-yl] acetic acid
The hydrolysis procedure in Synthetic Example 27 was followed using methyl 2- [4-{l- [5- (4-bromophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl} - piperazin-1-yl] acetate to give the desired product (yield
43%) . Morphology: pale yellow solid
LC/MS: condition 1, retention time 3.45 (min)
LC/MS (ESI+)m/z; 497, 499 [M+l]+.
LC/MS (ESI")m/z; 495, 497 [M-I]"
SYNTHETIC EXAMPLE 29 Synthesis of 3- [4-{l- [5- (4-bromophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperazin-1-yl]propionic acid
Methyl 3- [4-{l- [5- (4-bromophenyl) -4-hydroxyth.ioph.en-3- yl] -ethylidene-hydrazinothiocarbonyl}-piperazin-1- yl]propionate
The condensation procedure in Synthetic Example 27 was followed using ethyl 3- [4- hydrazinothiocarbonylpiperazin-1-yl]propionate prepared in Reference Synthetic Example 11 to give the crude desired product (yield 13%) . The crude product was used directly for the next reaction.
LC/MS : condition 1, retention time 3.05 (min)
LC/MS (ESI+)m/z; 539, 541 [M+l] +
LC/MS (ESI")m/z; 537, 539 [M-I]" 3- [4-{l- [5- (4-bromophenyl) -4-hydroxythiophen-3-yl] - ethylidene-hydrazinothiocarbonyl}-piperazin-1- yl]propionic acid The hydrolysis procedure in Synthetic Example 2 was followed using methyl 3- [4-{l- [5- (4-bromophenyl) -4- hydroxythiophen-3-yl] -ethylidene-hydrazinothiocarbonyl}- piperazin-1-yl]propionate and ethanol as the solvent to give the desired product (yield 55%) . Morphology: pale yellow solid
LC/MS: condition 1, retention time 3.07 (min) LC/MS (ESI+)m/z; 511, 513 [M+l] + LC/MS (ESI")m/z; 509, 511 [M-I]" The structural formulae of the compounds obtained in the Synthetic Examples are given below.
REP. SYN. REF. SYN. REF. SYN. REF. SYN. REF. SYN.
EX. 1 EX. 2 EX. 3 EX. 4 EX. 5
Figure imgf000599_0001
REF. SYN. REF. SYN. REF. SYN. REF. SYN.
EX. 6 EX. 7 EX. 8 EX. 9
Figure imgf000599_0002
REF. SYN. REF. SYN.
EX. 10 EX. 11
Figure imgf000599_0003
SYN . EX . 1 SYN. EX. 2 SYN. EX. 3 SYN. EX. 4
Figure imgf000600_0001
SYN. EX. 5 SYN. EX. 6 SYN. EX. 7
Figure imgf000600_0002
SYN. EX. 8 SYN. EX. 9 SYN. EX. 10 SYN. EX. 11
Figure imgf000600_0003
SYN. EX. 12 SYN. EX. 13 SYN. EX. 14 SYN. EX. 15
Figure imgf000600_0004
Figure imgf000601_0001
ASSAY EXAMPLE 1
Stimulation of Proliferation of a Thrombopoietin (TPO) - dependent Cell Line
The reactivity of the compound of Synthetic Example 4 of the present invention with thrombopoietin (TPO) receptor was assayed using a human leukemic cell line, UT7/EPO-mpl. (1) Cells and cell culture
UT7/EP0-mpl is a stable transformed cell line obtained by introducing into human leukemic cell line UT7/EPO a vector that induces expression of human TPO receptor {c-τnpl) under control of-.cytomegalovirus immediate^early promoter by the method of Takatoku et al. (J. Biol. Chem., 272:7259-7263 (1997)) . Proliferation of this cell line is stimulated by TPO, while its mother cell line UT7/EP0 exhibits no response to TPO. These two cell lines were subcultured in Iscove's modified Dulbecco's medium (IMDM; GIBCO) containing 10% fetal bovine serum (FBS; Thermo Electron or BioWest) using a CO2 incubator (5% CO2, 37°C) . (2) Cell proliferation assay
The subcultured cells described above were washed twice with phosphate buffered saline (PBS) and suspended in IMDM containing 10% FBS at a cell density of 6 x 104 cells/ml. The cell suspension was transferred to a 96- well tissue culture plate (CORNING) in 100-μl aliquots. Then either TPO (Pepro Tech EC) or the compound of Synthetic Example 4 dissolved in dimethyl sulfoxide (DMSO) was diluted 83-fold with IMDM containing 10% FBS and added to the aforementioned cell suspension in 20-μl aliquots. The cell suspension was incubated in a CO2 incubator (5% CO2, 37°C) for 4 days. Cell proliferation was assayed using WST-8 reagent (Kishida Chemical Co., Ltd.) according to instructions by the manufacturer. A 10-μl aliquot of 5 mM WST-8 reagent solution was added to each well of the tissue culture plate, and the plate was incubated at 370C for 4 h. The formazan pigment generated was detected by measuring the absorbance at 450 nm with a 96-well microplate reader (Nihon Molecular Devices, Spectramax 190) . Fig. 1 shows the results with UT7/EPO-mpl cells, while Fig. 2 shows data obtained with UT7/EPO cells expressing no TPO receptor. Fig. 1 demonstrates that proliferation of TPO- responsive UT7/EPO-mpl cells was stimulated by the compound of Synthetic Example 4 in a concentration- dependent manner, while no effect of this compound on proliferation was observed with UT7/EPO, the mother cell line, as shown in Fig. 2. These results indicate that the compound of Synthetic Example 4 of the present invention acts on the TPO receptor selectively as an activator. ASSAY EXAMPLE 2
The compounds of the following Synthetic Examples were tested according to the method of Assay Example 1 to determine the concentration of each compound that yields a growth rate corresponding to 50% of the growth of human leukemic cell line UT-7/EPO-mpl observed in the presence of 10 ng/ml TPO (EC50) . The results are summarized in Table 4.
TABLE 4
SYNTHETIC EXAMPLES EC50
No. (ng/mL)
1 31
ClT
2 3.2 ■
3 24
4 5.6
5 30
6 14
7 28
8 25
2.3
10 2.7
11 2.9
12 2.1
13 2.6
14 2.6
15 2.6
16 3.8
17 7.8
18 22
19 26
20 3.1
21 23
22 21
23 33
FORMULATION EXAMPLE 1
A granule preparation containing the following ingredients is prepared. Ingredients
Compound represented by the formula (1) 10 mg Lactose 700 mg
Corn Starch 274 mg
HPC-L 16 mg
1000 mg A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed in a V-type blender. The powder mixture is kneaded with a low-viscosity hydroxypropylcellulose (HPC-L) aqueous solution, granulated (extrusion granulation, die size 0.5-1 mm) and dried. The resulting dry granules are sifted through a shaking sieve (12/60 mesh) to obtain a granule preparation. FORMULATION EXAMPLE 2
A powder preparation for capsulation containing the following ingredients is prepared, Ingredients
Compound represented by the formula (1) 10 mg Lactose • 79 mg
Corn Starch 10 mg
Magnesium Stearate 1 mg
100 mg A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed with magnesium stearate in a V-type blender. The 10% powder is put in hard gelatin capsules No. 5, 100 mg each. FORMULATION EXAMPLE 3
A granule preparation for capsulation containing the following ingredients is prepared. Ingredients
Compound represented by the formula (1) 15 mg Lactose . 90 mg
Corn Starch 42 mg
HPC-L ' 3 mg
150 mg A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed in a V-type blender.' The powder mixture is kneaded with a low-viscosity hydroxypropylcellulose (HPC-L) aqueous solution, granulated and dried. The resulting dry granules are sifted through a shaking sieve (12/60 mesh) . The granules are put in hard capsules No. 4, 150 mg each. FORMULATION EXAMPLE 4 A tablet preparation containing the following ingredients is prepared. Ingredients
Compound represented by the formula (1) 10 mg Lactose 90 mg
Microcrystalline cellulose 30 mg
Magnesium Stearate 5 mg
CMC-Na 15 mg
150 mg A compound represented by the formula (1) , lactose, microcrystalline cellulose and CMC-Na (carboxymethylcellulose sodium salt) are sifted through a
60-mesh sieve and mixed. The powder mixture is mixed with magnesium stearate to give a bulk powder mixture.
The powder mixture is compressed directly into 150 mg tablets . FORMULATION EXAMPLE 5
An intravenous preparation is prepared as follows .
Compound represented by the formula (1) 100 mg Saturated Fatty Acid Glyceride 1000 ml Solutions having the above-mentioned composition are usually administered to a patient intravenously at a rate of 1 ml per 1 minute.
INDUSTRIAL APPLICABILITY
The compounds of the present invention which have affinity for thrombopoietin receptor and act as thrombopoietin receptor agonists are useful as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective, especially as drugs for hematological disorders accompanied by abnormal platelet count and as drugs for diseases treated or prevented by stimulating differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, and are useful as medicines .

Claims

CLAIMS : 1 . A compound represented by the formula ( 1 )
Figure imgf000608_0001
wherein A is a nitrogen atom or CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxy1 group may be substituted with a C2_6 alkenyl group or a C2-6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-io alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a Ci-io alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a C1-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkylcarbonylamino group, a mono- or di-Ci-io alkylamino group, a Ci-io alkoxy group (the Ci_i0 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the Ci-io alkylcarbonylamino group, the mono- or di-Ci-i0 alkylamino group and the Ci-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-i4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Cα_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Cx-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_i4 aryl groups and C2-I4 aryloxy groups) , a C2-I4 aryloxy group (the C2_i4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of. C1-I0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Cx-I0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Cx-10 alkoxycarbonyl groups, CX-X0 alkylcarbonylamino groups, amino groups, mono- or di-Cx-X0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2_9 heterocyclic group, a C1-10 alkoxy group (the Ci-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group and the C1-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2_i4 aryloxy groups (the C2_14 aryl groups and the C2_i4 aryloxy groups may be substituted with one or more C1-5 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups), a C2-I4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-X0 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or (U-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the C1-K3 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Cx-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)mi-E- (CH2)m2- (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a Ci_10 alkyl group, a C2-I4 aryl group, a Ci_i0 alkoxy group, a C2_i4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a CI-IQ alkyl group, a C2-6 alkenyl group, a C2-s alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a C1-I0 alkoxycarbonyl group, a Ci_io alkylcarbonyl group (the Ci_i0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the Ci-io alkoxy group, the Ci_10 alkylcarbonyloxy group, the Ci-10 alkoxycarbonyl group and the Cx-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Cx-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Cx-X0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Cx-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Cx-I0 alkylcarbonylamino groups, amino groups, mono- or di-Cx_X0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_X4 aryl groups and C2-X4 aryloxy groups) ) , and each of ml and m.2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5) ) ) ) ,
B is an oxygen atom, a sulfur atom or NR9 (wherein R9 is a hydrogen atom, a hydroxy1 group, a formyl group, a Ci-io alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci_i0 alkylcarbonyloxy group, a Ci-io alkoxycarbonyl group, a Ci_i0 alkylcarbonyl group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci_i0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Cx-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2_i4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci-i0 alkylcarbonylamino groups, amino groups, mono- or CU-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups) or a C2_i4 aryloxy group (the C2-U-4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the C1-X0 alkyl groups may be substituted with one or more halogen atoms) , C2.β alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, C1-K5 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I-0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups)) (provided that when A is a nitrogen atom, B is not NH) ,. R1 is a C2-I4 aryl group (the C2-I4 aryl group may be substituted with one or. more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, Ci-I0 alkyl groups, C2-6 alkenyl groups, C2-6 alkynyl groups, Cx-I0 alkoxy groups, C1-I-0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, Ci-iQ alkoxycarbonyl groups (the Ci-I0 alkyl groups, the C2-6 alkenyl groups, the C2-6 alkynyl groups, the C1-I0 alkoxy groups, the C1-X0 alkylcarbonyl groups, the C1-10 alkylcarbonyloxy groups and the C1-10 alkoxycarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-Ii0 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-i4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1^6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , C2-14 aryl groups (the C2-14 aryl groups may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1^10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) , thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or two substituents selected from the group consisting of formyl groups, Ci-I0 alkyl groups, C2.6 alkenyl groups, C2-β alkynyl groups and C1-I0 alkylcarbonyl groups (the C1-X0 alkyl groups, the C2-6 alkenyl groups, the C2-e alkynyl groups and the Ci-I0 alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-H0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxy1 groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1^ alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) ) ,
L1 is a bond, CR10R11 (wherein each of R10 and R11 is independently a hydrogen atom or a Ci_6 alkyl group (the C1-G alkyl group may be .substituted with one or more halogen atoms) ) , an oxygen atom, a sulfur atom or NR12 (wherein R12 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-H-0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a C1-I0 alkylcarbonyl group (the Ci-I0 alkyl group, the C2.6 alkenyl group, the C2-6 alkynyl group, the Ci_10 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) ) ,
X is OR13, SR13 or NR14R15 (wherein R13 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1^0 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , and each of R14 and R15 is independently a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2_6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-^-0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci.6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2.14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-K3 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups)) ,
R2 is a hydrogen atom, a formyl group, a Ci-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1.^ alkoxy group, a Ci-10 alkylcarbonyl group (the C1-I0 alkyl group, the C2.6 alkenyl .group, the C2.6 alkynyl group, the Ci-10 alkoxy group and the Ci-i0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-10 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-i0 alkoxycarbonyl groups, CX.1O alkylcarbonylaraino groups, amino groups, mono- or di-Ci_10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the C1-X0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups),
L2 is a bond, CR34R35 (wherein each of R34 and R35 is independently a hydrogen atom or a Ci-6 alkyl group (the C1-S alkyl group may be substituted with one or more halogen atoms) ) , an oxygen atom, a sulfur atom or NR16 (wherein R16 is a hydrogen atom, a hydroxyl group, a formyl group, a Cx-I0 alkyl group, a C2.6 alkenyl group, a C2.6 alkynyl group, a Ci-10 alkoxy group, a C1-I0 alkylcarbonyloxy group, a Ci-10 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the CI-IQ alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-X0 alkoxy group, the C1-I0 alkylcarbonyloxy group, the Ci-10 alkoxycarbonyl group and the C1-X0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-i4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) ) ,
L3 is a bond, CR17R18 (wherein each of R17 and R18 is independently a hydrogen atom, a C1-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-I0 alkoxy group, a C1-I0 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1^10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms), C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups) ) , an oxygen atom, a sulfur atom or NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2_6 alkynyl group, a Ci-io alkoxy group, a Ci-io alkylcarbonyloxy group, a Ci_i0 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the Ci-io alkylcarbonyloxy group, the Ci_i0 alkoxycarbonyl group, the Ci-io alkoxy group and the Ci-io alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2_i4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-i4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Cx-I0 alkoxy groups, Ci_10 alkylcarbonyl groups, Cχ_10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups) ) ,
Y is an oxygen atom, a sulfur atom or NR23 (wherein R23 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group, a Ci-10 alkoxy group, a Ci-10 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Ci-io alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Cx-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-S alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2_i4 aryl group may be substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-xo alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Cx-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-αo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.14 aryl groups and C2-14 aryloxy groups) ) ,
L4 is a bond, CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2.6 alkynyl group, a Ci_i0 alkoxy group, a Ci-10 alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2_6 alkynyl group, the Ci-I0 alkoxy group and the Ci-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-10 alkylcarbonyl groups, Cx-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_i4 aryl groups and C2-14 aryloxy groups (the C2.14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-β alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_e alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2.6 alkynyl group, a Ci_i0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci_i0 alkoxycarbonyl group, a. Ci-I0 alkylcarbonyl group (the Ci-iQ alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci_i0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1-I0 alkylcarbonyl groups, Ci_10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-O-0 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-S alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-J-0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-L0 alkoxy groups, Ci-io alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-H0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2.14 aryloxy groups (the C2-14 aryl groups and the C2.14 aryloxy groups may be substituted with one or more C;L-6 alkyl groups (the Cx-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and When L4 is a bond, R3 is a methyl group (the methyl group may be optionally substituted with one or more substituents selected from the group consisting of C1-J-0 alkyl groups, C2-10 alkenyl groups, C2_10 alkynyl groups, C2-9 heterocyclic groups, Ci-io alkoxy groups, Ci_i0 thioalkyl groups, Ci_i0 alkylcarbonyl groups, mono- or di- Ci-io alkylamino groups, C1-I0 alkylcarbonyloxy groups, Ci_10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups
(the Ci-io alkyl groups, the C2-io alkenyl groups, the C2-I0 alkynyl groups, the C2.9 heterocyclic groups, the Ci_i0 alkoxy groups, the C1-X0 thioalkyl groups, the C1-X0 alkylcarbonyl groups, the mono- or di-Ci-I0 alkylamino groups, the Ci-I0 alkylcarbonyloxy groups, the Ci-io alkoxycarbonyl groups and the Ci_i0 alkylcarbonylamino groups may be optionally substituted with one or more C2-i4 aryl groups (the C2_14 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4 (wherein W1 is (CR24R25)n
(wherein each of R24 and R25 is independently a hydrogen atom or a C1^ alkyl group (the C1-S alkyl group may be substituted with one or more halogen atoms) , or R24 and R25 mean, together with each other, O= or S=, and n is 0, 1, 2 or 3) , an oxygen atom, a sulfur atom or NR36
(wherein R36 is a hydrogen atom, a C1-S alkyl group, a formyl group or a C1-S alkylcarbonyl group) , each of W2 and W3 is independently a hydrogen atom or a C1-3 alkyl group (the Ci_3 alkyl group may be substituted with one or more halogen atoms) , m is 0, 1, 2 or 3, and W4 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a C1-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a Ci-iLo alkoxy group, a Ci-io alkylcarbonyloxy group, a Ci-10 alkylcarbonylamino group, a mono- or di-Ci_i0 alkylamino group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group, the C1-10 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the C1-I0 alkylcarbonylamino group and the mono- or di-Ci_i0 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, thiol groups, phosphonic acid groups, sulfonic acid groups, tetrazole groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28, SOR28, COR28 (wherein R28 is a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group, a C2-i4 aryloxy group (the C2-i4 aryl group and the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-io alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2_i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or NR29R30 (wherein each of R29 and R30 is independently a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-I0 alkoxy group, a Cx-I0 alkylcarbonyloxy group, a Cx-I0 alkoxycarbonyl group, a. C1-10 alkylsulfonyl group, a Cx-xo alkylcarbonyl group (the C1-10 alkyl group, the C2_6 alkenyl group, the C2.6 alkynyl group, the C1-10 alkoxy group, the Cx_lo alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the Cx-lo alkylsulfonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Cx-Io alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the CI-IQ alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2-6 alkynyl groups, carboxyl group, sulfonyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups (the CI-IQ alkoxy groups may be substituted with one or more halogen atoms) , Ci-10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Cx-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_s alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl group, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-io alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci-io alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2.i4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), or R29 and R30, together with each other means - (CH2)ra3-G- (CH2)m4- (wherein G is an oxygen atom, a sulfur atom, CR31R32 (wherein each of R31 and R32 is independently a hydrogen atom, a Ci_i0 alkyl group, a
C2-I4 aryl group, a Ci-I0 alkoxy group, a C2-I4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a Ci_i0 alkoxy group, a Ci_i0 alkylcarbonyloxy group, a Cx-I0 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Ci-I0 alkyl group, the C2.6 alkenyl group, the C2-e alkynyl group, the Ci-I0 alkoxy group, the Ci-io alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Cx-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-X0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-3.4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the Ci_i0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, C1-10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5) ) ) , a tetrazole group or a phosphonic acid group) ) or one or more substituents independently represented by -W5 (CW6W7)mi0W8 (wherein W5, W6, W7 and mlO are the same as W1, W2, W3 and m, respectively, W1, W2, W3 and m are the same as defined above, and W8 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom., a nitro group, a cyano group, a Ci,10 alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-Ci_i0 alkylamino group (the C1-K5 alkyl group, the C2-e alkenyl group, the C2.6 alkynyl group, the C2_9 heterocyclic group, the C1-I0 alkoxy group, the Ci-io alkylcarbonyloxy group, the Ci-io alkylcarbonylamino group and the mono- or di- Ci-io alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-io alkylcarbonyl groups, Ci_10 alkylcarbonyloxy groups, C1-X0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28a, SOR28a, COR28a (wherein R28a is the same as R28, and R28 is the same as defined above) , a tetrazole group or a phosphonic acid group) ) and substituents independently represented by -W9 (CW10W11)mliW12 (wherein W9, W10, W11, W12 and mil are the same as W1, W2, W3, W8 and m, respectively, and W1, W2, W3, W8 and m are the same as defined above) ) , a C2-Io alkyl group, a C2-io alkenyl group, a C2-io alkynyl group or a C2-9 heterocyclic group (the C2-10 alkyl group, the C2-I0 alkenyl group, the C2-10 alkynyl group and the C2- 9 heterocyclic group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups, C2-10 alkenyl groups, C2_10 alkynyl groups, C2.9 heterocyclic groups, Ci-I0 alkoxy groups, C1-X0 thioalkyl groups, C±.1O alkylcarbonyl groups, mono- or di-Ci-no alkylamino groups, C1-X0 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, C1^10 alkylsulfonyl groups, C1-10 alkylaminocarbonyl groups, C1^10 alkylaminosulfonyl groups, C1-10 dialkylaminocarbonyl groups, C1-10 alkylcarbonylamino groups (the C1-10 alkyl groups, the C2-10 alkenyl groups, the C2-10 alkynyl groups, the C2-9 heterocyclic groups, the C1-10 alkoxy groups, the Ci-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-C1-10 alkylamino groups, the C1-10 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups, the Ci-10 alkylsulfonyl groups, the C1-10 alkylaminocarbonyl groups, the C1-I0 alkylaminosulfonyl groups, the C1-10 dialkylaminocarbonyl groups and the C1-10 alkylcarbonylamino groups may be' optionally substituted with one or more C2-14 aryl groups (the C2-I4 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4 (wherein W1, W2, W3, W4 and m are the same as defined above) ) or one or more substituents independently represented by -W5 (CW6W7)ml0W8 (wherein W5, W6, W7, W8 and mlO are the same as defined above) ) , substituents independently represented by W9 (CW10W11)mnW12 (wherein W9, W10, W11, W12 and mil are the same as defined above) and C2-14 aryl groups (the C2-I4 aryl groups may be optionally substituted with one or more substituents independently represented by -W13 (CW14W15)mi2W16 (wherein W13, W14, W15, W16 and ml2 are the same as W1, W2, W3, W4 and m, respectively, and W1, W2, W3, W4 and m are the same as defined above))) , or when L4 is CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a Ci-I0 alkylcarbonyl group (the C1-I0 alkyl group, the C2.6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-lo alkylcarbonyloxy groups, Ci_lo alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-CX-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-10 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2_14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a C1-10 alkyl group, a C2_6 alkenyl group, a C2_6 alkynyl group, a C1-X0 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the
Ci-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the Ci-10 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the C1-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_io alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di- Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2 -14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more CX-6 alkyl groups (the Ci_s alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the CX-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-io alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2_14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Cx-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , R3 is a C1-I0 alkyl group, a C2-io alkenyl group, a C2-io alkynyl group, a C2-9 heterocyclic group, a Ci-io alkoxy group, a Ci-I0 thioalkyl group, a C1-X0 alkylcarbonyl group, a mono- or di-C1-I0 alkylamino group, a Ci_i0 alkylcarbonyloxy group, a Ci-io alkoxycarbonyl group or a C1-10 alkylcarbonylamino group (the Ci-10 alkyl group, the C2-10 alkenyl group, the C2-IO alkynyl group, the C2-9 heterocyclic group, the C1-10 alkoxy group, the C1-10 thioalkyl group, the C1-10 alkylcarbonyl group, the mono- or di-C1-10 alkylamino group, the Ci-I0 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonylamino group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups, C2-10 alkenyl groups, C2-10 alkynyl groups, C2-9 heterocyclic groups, C1-10 alkoxy groups, C1-I0 thioalkyl groups, C1-I0 alkylcarbonyl groups, mono- or di- Ci-I0 alkylamino groups, Ci-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups (the C1-10 alkyl groups, the C2-10 alkenyl groups, the C2-10 alkynyl groups, the C2-9 heterocyclic groups, the C1-10 alkoxy groups, the Ci-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-Ci-I0 alkylamino groups, the C1-I0 alkylcarbonyloxy groups, the Ci-I0 alkoxycarbonyl groups and the Ci-I0 alkylcarbonylamino groups may be optionally substituted with one or more C2- 14 aryl groups (the C2-14 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4 (wherein W1, W2, W3, W4 and m are the same as defined above) ) or one or more substituents independently represented by -W5 (CW6W7)mi0W8 (wherein W5, W6, W7, W8 and mlO are the same as defined above) ) , substituents independently represented by -W9 (CW10W11J1111xW12 (wherein W9, W10, W11, W12 and mil are the same as defined above) and C2-14 aryl groups (the C2-I4 aryl groups may be optionally substituted with one or more substituents independently represented by
-W13(CW14W15)rai2W16 (wherein W13, W14, W15, W16 and ml2 are the same as defined above) ) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 2. The compound according to Claim 1, wherein L4 is a bond, R3 is a methyl group (the methyl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups, C2-I0 alkenyl groups, C2-io alkynyl groups, C2-9 heterocyclic groups, Ci-10 alkoxy groups, C1-I0 thioalkyl groups, Cχ-10 alkylcarbonyl groups, mono- or di-Ci-10 alkylamino groups, Ci-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups (the Ci-io alkyl groups, the C2-I0 alkenyl groups, the C2.10 alkynyl groups, the C2-9 heterocyclic groups, the Cx-I0 alkoxy groups, the C1-I0 thioalkyl groups, the C1-X0 alkylcarbonyl groups, the mono- or di-C1-H0 alkylamino groups, the Ci-I0 alkylcarbonyloxy groups, the C1-10 alkoxycarbonyl groups and the Ci_10 alkylcarbonylamino groups may be optionally substituted with one or more C2-14 aryl groups (the C2-14 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4 (wherein W1 is (CR24R25)n (wherein each of R24 and R25 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms) , or R24 and R25 mean, together with each other, O= or S=, and n is 0, 1, 2 or 3) , an oxygen atom, a sulfur atom or NR36 (wherein R36 is a hydrogen atom, a C1-6 alkyl group, a formyl group or a C1-6 alkylcarbonyl group) , each of W2 and W3 is independently a hydrogen atom or a C1-3 alkyl group (the C1-3 alkyl group may be substituted with one or more halogen atoms) , m is 0, 1,
2 or 3, and W4 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a Ci-10 alkoxy group, a Ci-10 alkylcarbonyloxy group, a Ci-lo alkylcarbonylamino group, a mono- or di-Ci_i0 alkylamino group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group, the Ci-lo alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-I0 alkylcarbonylamino group and the mono- or di-Ci-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_ro alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-QL-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, thiol groups, phosphonic acid groups, sulfonic acid groups, tetrazole groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_i0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28, SOR28, COR28 (wherein R28 is a hydroxyl group, a protected hydroxyl group, a C1-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a Cx-I0 alkoxy group (the Cx-I0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the C2-9 heterocyclic group and the Ci_10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Cx-X0 alkoxy groups, C1-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-X0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-X4 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-S alkyl groups (the Cx-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-X4 aryl group, a C2-14 aryloxy group (the C2_14 aryl group and the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the CX-10 alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2-e alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, CX-X0 alkoxy groups, C1-X0 alkylcarbonyl groups, C1- 0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-X0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or NR29R30 (wherein each of R29 and R30 is independently a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a Ci-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci_i0 alkylsulfonyl group, a Ci-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-I0 alkoxy group, the Ci_i0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group, the Ci-10 alkylsulfonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-β alkynyl groups, carboxyl group, sulfonyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, Ci_io alkoxy groups (the Ci-I0 alkoxy groups may be substituted with one or more halogen atoms) , Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Cx-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_e alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl group, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-iQ alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-iQ alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1.6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , or R29 and R30, together with each other means -(CH2)m3-G- (CH2)m4- (wherein G is an oxygen atom, a sulfur atom, CR31R32 (wherein each of R31 and R32 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a Ci_10 alkoxy group, a C2-i4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-Io alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a C1-I0 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.14 aryl groups and C2.14 aryloxy groups (the C2_14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2_i4 aryloxy groups (the C2_i4 aryl groups and the C2_14 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the d-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5) ) ) , a tetrazole group or a phosphonic acid group) ) or one or more substituents independently represented by -W5 (CW6W7)ml0W8 (wherein W5, W6, W7 and mlO are the same as W1, W2, W3 and m, respectively, W1, W2, W3 and m are the same as defined above, and W8 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2_9 heterocyclic group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-xo alkylcarbonylamino group, a mono- or di-Ci-io alkylamino group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group, the C1-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the C1-I0 alkylcarbonylamino group and the mono- or di- Ci-I0 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-10 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2.14 aryl groups and the C2_14 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28a, SOR28a, COR28a (wherein R28a is the same as R28, and R28 is the same as defined above) , a tetrazole group or a phosphonic acid group) ) and substituents independently represented by -W9(CW10W11)mllW12 (wherein W9, W10, W11, W12 and mil are the same as W1, W2, W3, W8 and m, respectively, and W1, W2, W3, W8 and m are the same as defined above)) , a C2-Io alkyl group, a C2.lo alkenyl group, a C2-I0 alkynyl group or a- C2_9 heterocyclic group (the C2-10 alkyl group, the C2-I0 alkenyl group, the C2-10 alkynyl group and the C2- 9 heterocyclic group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups, C2-10 alkenyl groups, C2-I0 alkynyl groups, C2_9 heterocyclic groups, C1-X0 alkoxy groups, C1-I0 thioalkyl groups, Ci-I0 alkylcarbonyl groups, mono- or CU-C1-K3 alkylamino groups, C1-^ alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylaminocarbonyl groups, Ci-I0 dialkylaminocarbonyl groups, Ci-I0 alkylcarbonylamino groups (the Ci-I0 alkyl groups, the C2-I0 alkenyl groups, the C2-I0 alkynyl groups, the C2-9 heterocyclic groups, the C1-10 alkoxy groups, the Ci-I0 thioalkyl groups, the Ci-10 alkylcarbonyl groups, the mono- or di-Ci-I0 alkylamino groups, the C1-10 alkylcarbonyloxy groups, the Ci-I0 alkoxycarbonyl groups, the Ci-I0 alkylaminocarbonyl groups, the C1-10 dialkylaminocarbonyl groups and the Ci-I0 alkylcarbonylamino groups may be optionally substituted with one or more C2-14 aryl groups (the C2.14 aryl groups may be optionally substituted with one or more substituents independently represented by -W1 (CW2W3)mW4 (wherein W1, W2, W3, W4 and m are the same as defined above) ) or one or more substituents independently represented by -W5 (CW6W7)ml0W8 (wherein W5, W6, W7, W8 and mlO are the same as defined above) ) , substituents independently represented by W9 (CW10W11)mllW12 (wherein W9, W10, W11, W12 and mil are the same as defined above) and C2-I4 aryl groups (the C2-I4 aryl groups may be optionally substituted with one or more substituents independently represented by -W13 (CW14W15)ml2W16 (wherein W13, W14, W15, W16 and ml2 are the same as W1, W2, W3, W4 and m, respectively, and W1, W2, W3, W4 and m are the same as defined above))), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
3. The compound according to Claim 1, wherein L4 is CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a Ci_10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-I0 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups .may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-β alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Ci-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2_14 aryloxy groups (the C2-i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Cx-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Cχ-10 alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, Cx-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, QL-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_i4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and R3 is a C1- 10 alkyl group, a C2-I0 alkenyl group, a C2-I0 alkynyl group, a C2-9 heterocyclic group, a C1-X0 alkoxy group, a C1-I0 thioalkyl group, a C1-X0 alkylcarbonyl group, a mono- or di-Ci_10 alkylamino group, a Cx-10 alkylcarbonyloxy group, a C1-I0 alkoxycarbonyl group or a C1-I0 alkylcarbonylamino group (the Ci-I0 alkyl group, the C2-io alkenyl group, the C2-10 alkynyl group, the C2_9 heterocyclic group, the Cα-αo alkoxy group, the Ci-I0 thioalkyl group, the C1-I0 alkylcarbonyl group, the mono- or di-Ci_i0 alkylamino group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonylamino group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups, C2-10 alkenyl groups, C2-10 alkynyl groups, C2-9 heterocyclic groups, C1-10 alkoxy groups, Ci-I0 thioalkyl groups, Ci_i0 alkylcarbonyl groups, mono- or di- Ci-I0 alkylamino groups, Ci-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups (the C1-10 alkyl groups, the C2-10 alkenyl groups, the C2-10 alkynyl groups, the C2-9 heterocyclic groups, the C1-10 alkoxy groups, the C1-10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-C1-10 alkylamino groups, the C1-10 alkylcarbonyloxy groups, the Ci-10 alkoxycarbonyl groups and the C1-10 alkylcarbonylamino groups may be optionally substituted with one or more C2- 14 aryl groups (the C2-14 aryl groups may be optionally substituted with one or more substituents independently represented by -W1(CW2W3)mW4 (wherein W1 is (CR24R25)n (wherein each of R24 and R25 is independently a hydrogen atom or a Ci-6 alkyl group (the Cx-6 alkyl group may be substituted with one or more halogen atoms) , or R24 and R25 mean, together with each other, 0= or S=, and n is 0, 1, 2 or 3) , an oxygen atom, a sulfur atom or NR36 (wherein R36 is a hydrogen atom, a Cx-6 alkyl group, a formyl group or a Ci-6 alkylcarbonyl group) , each of W2 and W3 is independently a hydrogen atom or a Ci_3 alkyl group (the Ci_3 alkyl group may be substituted with one or more halogen atoms) , m is 0, 1, 2 or 3, and W4 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a C2_9 heterocyclic group, a C1-I0 alkoxy group, a C1-I0 alkylcarbonyloxy group, a Ci-I0 alkylcarbonylamino group, a mono- or di-Ci_i0 alkylamino group (the C1-I0 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group, the Ci_i0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkylcarbonylamino group and the mono- or di-Ci-i0 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci_lo alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_i4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of. Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Cx-I0 alkylcarbonylamino groups, amino groups, mono- or di-Cx-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, thiol groups, phosphonic acid groups, sulfonic acid groups, tetrazole groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_i0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28, ,SOR28, COR28 (wherein R28 is a hydroxyl group, a protected hydroxyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-β alkynyl group, a C2-g heterocyclic group, a Ci-I0 alkoxy group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the C2-9 heterocyclic group and the C1-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Cx-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group, a C2-i4 aryloxy group (the C2-I4 aryl group and the C2_i4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or NR29R30 (wherein each of R29 and R30 is independently a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2.6 alkenyl group, a C2_6 alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-10 alkoxycarbonyl group, a Ci-10 alkylsulfonyl group, a CI_IQ alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-e alkynyl group, the Ci-I0 alkoxy group, the Ci-10 alkylcarbonyloxy group, the Cx-10 alkoxycarbonyl group, the Ci-I0 alkylsulfonyl group and the Ci-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-I4 aryloxy groups (the C2-24 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms), C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl group, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , or R29 and R30, together with each other means - (CH2)m3-G- (CH2)m4- (wherein G is an oxygen atom, a sulfur atom, CR31R32 (wherein each of R31 and R32 is independently a hydrogen atom, a Ci-I0 alkyl group, a C2-I4 aryl group, a Ci-I0 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci-io alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Ci-io alkyl group, the C2_6 alkenyl group, the C2.s alkynyl group, the Cx-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Cx-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups (the C2_i4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Cχ-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-i4 aryl group (the C2-i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-K) alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen altoms) , C2.6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, CV10 alkoxy groups, Ci-io alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2_i4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) ) , and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5) ) ) , a tetrazole group or a phosphonic acid group.) ) or one or more substituents independently represented by -W5 (CW6W7)mi0W8 (wherein W5, W6, W7 and mlO are the same as W1, W2, W3 and m, respectively, W1, W2, W3 and m are the same as defined above, and W8 is a hydroxyl group, a protected hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2_6 alkynyl group, a C2_9 heterocyclic group, a Ci_io alkoxy group, a C1-X0 alkylcarbonyloxy group, a C1-IO alkylcarbonylamino group, a mono- or di-Ci-io alkylamino group (the Ci_i0 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the C2_9 heterocyclic group, the Ci-io alkoxy group, the Ci-io alkylcarbonyloxy group, the Ci-io alkylcarbonylamino group and the mono- or di- Ci-io alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-H0 alkoxy groups, C1-^ alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, C1-H0 alkoxycarbonyl groups, CX-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0. alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups (the C2-i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , SO2R28a, SOR28a, COR28a (wherein R28a is the same as R28, and R28 is the same as defined above) , a tetrazole group or a phosphonic acid group) ) , substituents independently represented by -W9 (CW10W11)mllW12 (wherein W9, W10, W11, W12 and mil are the same as W1, W2, W3, W8 and m, respectively, and W1, W2, W3, W8 and m are the same as defined above) and C2-14 aryl groups (the C2-I4 aryl groups may be optionally substituted with one or more substituents independently represented by -W13 (CW14W15)ral2W16 (wherein W13, W14, W15, W16 and ml2 are the same as W1, W2, W3, W4 and m, respectively, and W1, W2, W3, W4 and m are the same as defined above) ) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
4. The compound according to any one of Claims 1 to 3, wherein A is a nitrogen atom, and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
5. The compound according to any one of Claims 1 to 3, wherein A is a nitrogen atom, and B is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof .
6. The compound according to any one of Claims 1 to 3, wherein A is a nitrogen atom, and B is NR9 other than NH (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-io alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci_i0 alkylcarbonyloxy group, a C1-I0 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci_i0 alkyl group, the C2-β alkenyl group, the C2-β alkynyl group, the Ci-I0 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci-io alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C^6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-IL0 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms), C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C;L_10 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or CU-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2.14 aryloxy groups) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
7. The compound according to any one of Claims 1 to 3, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl group or a C2.6 alkynyl group) , a thiol group (the thiol group may be substituted with a Cχ.lo alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group or a Ci_io alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-β alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2_s alkenyl group, a C2_6 alkynyl group, a Ci-10 alkylcarbonylamino group, a mono- or di-Ci-I0 alkylamino group, a Ci-I0 alkoxy group (the Ci_10 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the Ci-10 alkylcarbonylamino group, the mono- or di-C1-I0 alkylamino group and the QL-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, QL_I0 alkylcarbonyl groups, QL-I0 alkylcarbonyloxy groups, QL-I0 alkoxycarbonyl groups, C1-H0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Cχ-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-X4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci_i0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, Ci_10 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, Cχ_10 alkylcarbonylamino groups, amino groups, mono- or di-Cχ_10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2.14 aryl groups and C2-14 aryloxy groups) , a C2-14 aryloxy group (the C2_14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-X0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, C1-X0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, Cχ-10 alkoxycarbonyl groups, Cχ-10 alkylcarbonylamino groups, amino groups, mono- or di-Cχ-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2.14 aryloxy groups) , SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a Cx-I0 alkyl group, a C2.6 alkenyl group, a C2-S alkynyl group, a C2_9 heterocyclic group, a Ci-I0 alkoxy group (the Ci-J0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group and the Cx-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the CX-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-X4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1^10 alkylcarbonyl groups, Ci_lo alkylcarbonyloxy groups, C1^10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Cj-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Ci-I0 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the Ci_10 alkoxycarbonyl group and the C1-HO alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_i0 alkoxy groups, Ci_10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1- 0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the C1.6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2.14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1- 0 alkoxy groups, C1-10 alkylcarbonyl groups, C1.10 alkylcarbonyloxy groups, C1-I10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)ml-E- (CH2)m2- (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a Ci-10 alkyl group, a C2-I4 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-H-0 alkyl group, a C2.6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the Ci_i0 alkyl group, the C2_e alkenyl group, the C2-6 alkynyl group, the Ci_10 alkoxy group, the Ci-I0 alkylcarbonyloxy group, the C1^10 alkoxycarbonyl group and the Ci_i0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_10 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups (the C2-I4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) ) , and each of ml and m.2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5) ) ) ) , and B is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
8. The compound according to any one of Claims 1 to 3, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl group or a C2-e alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a Ci-io alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2.6 alkenyl groups or one or two C2_6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci-I0 alkyl group, a C2-s alkenyl group, a C2_6 alkynyl group, a Ci-io alkylcarbonylamino group, a mono- or di-Cx-I0 alkylamino group, a Ci_i0 alkoxy group (the Cx-I0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the Ci-io alkylcarbonylamino group, the mono- or di-Ci-I0 alkylamino group and the Ci_i0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci-io alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-i4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Cx-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-10 alkyl groups (the Cx-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, CX-I0 alkylcarbonyl groups, Cx-10 alkylcarbonyloxy groups, Cx-X0 alkoxycarbonyl groups, Cx_xo alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2-14 aryloxy groups), a C2-14 aryloxy group (the C2_x4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Cx-lo alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, C1-^-0 alkylcarbonyl groups, Cx.lo alkylcarbonyloxy groups, Cx_xo alkoxycarbonyl groups, Cx-lo alkylcarbonylamino groups, amino groups, mono- or di-Cx_xo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2-14 aryloxy groups), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2_6 alkenyl group, a C2_6 alkynyl group, a C2-9 heterocyclic group, a Ci-I0 alkoxy group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C2-9 heterocyclic group and the Ci-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-i4 aryloxy groups (the C2-i4 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) , a C2-I4 aryloxy group (the C2-i4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Ci-io alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci-I0 alkylcarbonyl group (the Ci_i0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one ύr more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Cj._i0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-I4 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-io alkyl groups (the Ci-io alkyl groups may be substituted with one or more halogen atoms), C2-6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-10 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-io alkylcarbonyloxy groups, Ci-io alkoxycarbonyl groups, Ci_i0 alkylcarbonylamino groups, amino groups, mono- or di-Ci_i0 alkylamino groups, hydroxyl groups,, protected hydroxyl groups, C2-I4 aryl groups and C2.14 aryloxy groups) , or R6 and R7 mean, together with each other, - (CH2)ml-E- (CH2)m2- (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom,, a Ci-io alkyl group, a C2-I4 aryl group, a C1-I0 alkoxy group, a C2-I4 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2_6 alkynyl group, a Ci-I0 alkoxy group, a C1-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci-I0 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the Ci-I0 alkoxy group, the Ci_i0 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-X0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_io alkoxy groups, Ci-I0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-14 aryl groups and the C2-i4 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups (the Ci-I0 alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Cx-10 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-io alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-i4 aryloxy groups)), and each of ml and m2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5) ) ) ) , and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
9. The compound according to any one of Claims 1 to 3, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl group or a C2-6 alkynyl group) , a thiol group (the thiol group may be substituted with a Ci-10 alkyl group, a C2-e alkenyl group, a C2-6 alkynyl group or a Ci-io alkylcarbonyl group) , an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups) , a formyl group, a halogen atom, a nitro group, a cyano group, a Ci_i0 alkyl group, a C2-6 alkenyl group, a C2-β alkynyl group, a Ci-io alkylcarbonylamino group, a mono- or di-C1-I0 alkylamino group, a C1-I0 alkoxy group (the Cx-I0 alkyl group, the C2-6 alkenyl group, the C2.6 alkynyl group, the Ci-10 alkylcarbonylamino group, the mono- or di-Ci-i0 alkylamino group and the C1-I0 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, Ci_i0 alkylcarbonyl groups, Ci-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1^0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups (the C2-14 aryl groups and the C2-I4 aryloxy groups may be substituted with one or more Ci-6 alkyl groups (the C1-S alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-I4 aryl group (the C2-i4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups), a C2-i4 aryloxy group (the C2-I4 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2_6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclic group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-S alkenyl group, the C2.6 alkynyl group, the C2-9 heterocyclic group and the Ci_10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, CX-10 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci.-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2_14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1^ alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or. more halogen atoms) ) , a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Ci-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C^10 alkoxy groups, Ci_i0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci-10 alkoxycarbonyl groups, Ci-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2.14 aryloxy groups) , a C2-I4 aryloxy group (the C2_14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of C1-X0 alkyl groups (the Cx-Io alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2.6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, Ci_10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-X0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-14 aryloxy groups) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2~6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-X0 alkyl groups (the C1-I0 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci_10 alkoxy groups, Ci_10 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-X0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-χ4 aryl groups and C2.X4 aryloxy groups) , or R5 and R7 mean, together with each other, - (CH2)mi~E- (CH2)m2- (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-X0 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Cx-I0 alkoxy group, a Cx.xo alkylcarbonyloxy group, a Cx-xo alkoxycarbonyl group, a Ci-io alkylcarbonyl group (the Ci-I0 alkyl group, the C2_6 alkenyl group, the C2-6 alkynyl group, the Cx-I0 alkoxy group, the Ci-10 alkylcarbonyloxy group, the C1-I0 alkoxycarbonyl group and the CX-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, C1-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-Ci_lo alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-i4 aryl groups and C2-i4 aryloxy groups (the C2-i4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more CX-6 alkyl groups (the Ci_6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of Cwo alkyl groups (the C2-I0 alkyl groups may be substituted with one or more halogen atoms) , C2.6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, C1-10 alkylcarbonyl groups, Ci_i0 alkylcarbonyloxy groups, Ci_10 alkoxycarbonyl groups, C1-I0 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2_14 aryl groups and C2-14 aryloxy groups)), and each of ml and m2 is independently an integer of from 0 to 5 provided that ml+m2 is 3, 4 or 5)))), and B is NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-10 alkyl group, a C2-5 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-Io alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) , a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-14 aryloxy groups) or a C2-I4 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of Ci-io alkyl groups (the Ci-io alkyl groups may be substituted with one or more halogen atoms), C2-6 alkenyl groups, C2-β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, Ci-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, Ci-io alkylcarbonylamino groups, amino groups, mono- or di-C1-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2_14 aryloxy groups) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
10. The compound according to any one of Claims 1 to 9, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
11. The compound according to any one of Claims 1 to 10, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
12. The compound according to any one of Claims 1 to 11, wherein L3 is NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci-I0 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a Ci-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a Ci-I0 alkoxycarbonyl group, a C1-X0 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the Ci_i0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-io alkoxy groups, Ci-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, Ci_i0 alkoxycarbonyl groups, Cx-I0 alkylcarbonylamino groups, amino groups, mono- or di-CX-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-X4 aryloxy groups (the C2-X4 aryl groups and the C2-14 aryloxy groups may be substituted with one or more Cx_6 alkyl groups (the Cx-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-I4 aryl group (the C2-I4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-I0 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-X0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
13. The compound according to any one of Claims 1 to 11, wherein L3 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
14. The compound according to any one of Claims 3 to 11, wherein L3 is the same as defined in Claim 12, and L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a Ci_i0 alkyl group, a C2_6 alkenyl group, a C2-6 alkynyl group, a C1-I0 alkoxy group, a C1-I0 alkylcarbonyloxy group, a C1-X0 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-H0 alkyl group, the C2-6 alkenyl group, the C2-β alkynyl group, the C1-X0 alkoxy group, the C1-X0 alkylcarbonyloxy group, the Ci-I0 alkoxycarbonyl group and the Ci-I0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, Ci-I0 alkoxy groups, C1-I0 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-i4 aryl groups and the C2.14 aryloxy groups may be substituted with one or more Ci_6 alkyl groups (the Ci-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-I0 alkyl groups (the Cx-I0 alkyl groups may be substituted with one or more halogen atoms) , C2_6 alkenyl groups, C2~β alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, Ci.10 alkylcarbonyl groups, Ci-lo alkylcarbonyloxy groups, C1-X0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups, amino groups, mono- or di-Ci-I0 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-I4 aryl groups and C2-I4 aryloxy groups) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
15. The compound according to any one of Claims 3 to 11, wherein L3 is the same as defined in Claim 13, and L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-K) alkyl group, a C2-β alkenyl group, a C2-6 alkynyl group, a C1-I0 alkoxy group, a Ci-I0 alkylcarbonyloxy group, a C1-X0 alkoxycarbonyl group, a C1-XO alkylcarbonyl group (the Ci-I0 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-X0 alkoxy group, the C1-I0 alkylcarbonyloxy group, the Cχ-lo alkoxycarbonyl group and the Cχ-χ0 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-X0 alkoxy groups, Cχ-lo alkylcarbonyl groups, C1-X0 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or (Ui-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups (the C2-14 aryl groups and the C2-14 aryloxy groups may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms) ) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups (the C1-10 alkyl groups may be substituted with one or more halogen atoms) , C2-6 alkenyl groups, C2-6 alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10 alkoxy groups, C1-10 alkylcarbonyl groups, C1-10 alkylcarbonyloxy groups, C1-10 alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups, amino groups, mono- or di-C1-10 alkylamino groups, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups and C2-14 aryloxy groups)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
16. The compound according to Claim 14 or 15, wherein L4 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
17. The compound according to any one of Claims 2 and 4 to 11, wherein L3 is the same as defined in Claim 12, and L4 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
18. The compound according to any one of Claims 2 and 4 to 11, wherein L3 is the same as defined in Claim 13, and L4 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
19. The compound according to any one of Claims 14 to 18, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
20. The compound according to any one of Claims 14 to 18, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
21. The compound according to Claim 19 or 20, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
22. The compound according to any one of Claims 19 to 21, wherein R3 is a C2-9 heterocyclic group (the C2-9 heterocyclic group may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups, tetrazole groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkoxy groups, Cx-I0 thioalkyl groups, Ci-I0 alkylcarbonyl groups, Ci-I0 alkylcarbonyloxy groups, Ci-I0 alkylcarbonylamino groups and mono- or di- Ci-io alkylamino groups) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
23. The compound according to any one of Claims 19 to 21, wherein R3 is a C2~9 heterocyclic group (the C2-9 heterocyclic group is substituted with a substituent selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a sulfamoyl group, a tetrazole group and a Ci_10 alkoxycarbonyl group and with a substituent selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamoyl group, a sulfamoyl group, a tetrazole group, a Ci-I0 alkoxycarbonyl group, a nitro group, a cyano group, a halogen atom, a C1-I0 alkyl group, a Ci_i0 alkyl group substituted with one or more fluorine atoms, a sulfamoyl group substituted with a Ci-I0 alkyl group, a carbamoyl group substituted with a Ci-I0 alkyl group and a C1-Io alkylcarbonylamino group) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof .
24. The compound according to any one of Claims 19 to 21, wherein R3 is a C1.10 alkyl group or a C2-I0 alkenyl group (the Ci-I0 alkyl group and the C2-I0 alkenyl group may be optionally substituted with one or more substituents selected from the group consisting of Ci-I0 alkyl groups, C2-IO alkenyl groups, Ci-I0 alkoxy groups, Ci_i0 thioalkyl groups, Ci-I0 alkylcarbonyl groups, mono- or di-Ci-i0 alkylamino groups, Ci-io alkylcarbonyloxy groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkylcarbonylamino groups (the Ci-I0 alkyl groups, the C2-I0 alkenyl groups, the Ci-I0 alkoxy groups, the Ci-I0 thioalkyl groups, the C1-I0 alkylcarbonyl groups, the mono- or di-Ci_i0 alkylamino groups, the Ci-I0 alkylcarbonyloxy groups, the Cx-I0 alkoxycarbonyl groups and the Ci-I0 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups, tetrazole groups, Ci-I0 alkoxycarbonyl groups, Ci-I0 alkoxy groups, Ci_10 thioalkyl groups, Ci-I0 alkylcarbonyl groups, C1-I0 alkylcarbonyloxy groups, Ci-I0 alkylcarbonylamino groups and mono- or di- C1-I0 alkylamino groups) , nitro group, halogen atoms, hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups and tetrazole groups) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
25. The compound according to any one of Claims 19 to 21, wherein R3 is a Ci_i0 alkyl group or a C2-O-0 alkenyl group (the C1-I0 alkyl group and the C2-io alkenyl group may be optionally substituted with one or more substituents selected from the group consisting of C1-10 alkyl groups, C2-6 alkenyl groups, C1-10 alkoxy groups, C1-10 thioalkyl groups, C1-10 alkylcarbonyl groups, mono- or CU-C1-10 alkylamino groups, C1-10 alkylcarbonyloxyl groups,
Figure imgf000692_0001
alkoxycarbonyl groups, C1-10 alkylcarbonylamino groups
(the C1-10 alkyl groups, the C2-β alkenyl groups, the C1-10 alkoxy groups, the C1.10 thioalkyl groups, the C1-10 alkylcarbonyl groups, the mono- or di-C1-10 alkylamino groups, the C1-10 alkylcarbonyloxyl groups, the C1-10 alkoxycarbonyl groups and the C1-10 alkylcarbonylamino groups may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups and tetrazole groups) , halogen atoms, nitro groups, hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups and tetrazole groups) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
26. The compound according to any one of Claims 19 to 21, wherein R3 is a C2-g heterocyclic group (the C2-9 heterocyclic group is substituted with one or more substituents selected from the group consisting of hydroxyl groups, amino groups, halogen atoms, carboxyl groups, sulfonic acid groups, carbamoyl groups, hydroxycarbamoyl groups, cyanocarbamoyl groups, sulfamoyl groups, hydroxysulfamoyl groups, cyanosulfamoyl groups, thiocarbamoyl groups, -CH2COOH, -OCH2COOH, -NHCH2COOH, -CH2OH, -OCH2OH, -NHCH2OH, -CH2CH2OH, -(C=O)COOH, -CH2(C=O)COOH, -NH(C=O)COOH, -NHSO2NH2, d-10 alkyl groups, Ci-io alkylsulfonyl groups, Ci-I0 alkylaminosulfonyl groups, Cx-IO alkylcarbonyl groups, Ci_i0 alkylaminocarbonyl groups and Ci-10 dialkylaminocarbonyl groups (the Cx-I0 alkyl groups, the Ci-I0 alkylsulfonyl groups, the Ci-I0 alkylaminosulfonyl groups, the Ci-I0 alkylcarbonyl groups, the Ci_io alkylaminocarbonyl groups and the Ci-I0 dialkylaminocarbonyl groups may be substituted with one or more substituents selected from the group consisting of phenyl groups, thienyl groups, furyl groups, pyridyl groups, nitro groups, cyano groups, hydroxyl groups, amino groups, carboxyl groups, phosphonic acid groups, sulfonic acid groups, carbamoyl groups, sulfamoyl groups and tetrazole groups) ) , a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
27. The thrombopoietin receptor activator according to any one of Claims 1 to .26.
28. A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective, which contains the thrombopoietin receptor activator according to Claim 27, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
29. A platelet increasing agent containing the thrombopoietin receptor activator according to Claim 27, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
30. Medicament containing the compound according to any one of Claims 1 to 26, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, as an active ingredient.
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