WO2006060309A3 - Compositions and methods for ex vivo preservations of organs - Google Patents

Compositions and methods for ex vivo preservations of organs Download PDF

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Publication number
WO2006060309A3
WO2006060309A3 PCT/US2005/042888 US2005042888W WO2006060309A3 WO 2006060309 A3 WO2006060309 A3 WO 2006060309A3 US 2005042888 W US2005042888 W US 2005042888W WO 2006060309 A3 WO2006060309 A3 WO 2006060309A3
Authority
WO
WIPO (PCT)
Prior art keywords
organs
methods
compositions
preservations
vivo
Prior art date
Application number
PCT/US2005/042888
Other languages
French (fr)
Other versions
WO2006060309A2 (en
Inventor
Yoshifumi Naka
David J Pinsky
David M Stern
Original Assignee
Univ Columbia
Yoshifumi Naka
David J Pinsky
David M Stern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Yoshifumi Naka, David J Pinsky, David M Stern filed Critical Univ Columbia
Publication of WO2006060309A2 publication Critical patent/WO2006060309A2/en
Publication of WO2006060309A3 publication Critical patent/WO2006060309A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention relates to methods for the activation of cAMP-dependent protein kinase (PKA) activity and/or cGMP-dependent protein kinase (PKG) activity in organs and portions thereof suitable for transplantation as a means for preservation/maintenance of the organs and portions thereof prior to transplant into the recipient. The present invention also relates to compositions comprising an activator of PKA and/or PKG kinase activity for use in the methods of the invention.
PCT/US2005/042888 2004-11-24 2005-11-22 Compositions and methods for ex vivo preservations of organs WO2006060309A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63110604P 2004-11-24 2004-11-24
US60/631,106 2004-11-24

Publications (2)

Publication Number Publication Date
WO2006060309A2 WO2006060309A2 (en) 2006-06-08
WO2006060309A3 true WO2006060309A3 (en) 2007-02-22

Family

ID=36565589

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/042888 WO2006060309A2 (en) 2004-11-24 2005-11-22 Compositions and methods for ex vivo preservations of organs

Country Status (1)

Country Link
WO (1) WO2006060309A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844345B2 (en) 2005-06-28 2023-12-19 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US12127554B2 (en) 2023-08-11 2024-10-29 Transmedics, Inc. Apparatus and method for ex vivo lung ventilation with a varying exterior pressure

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL311989A (en) 2004-10-07 2024-06-01 Transmedics Inc Systems and methods for ex-vivo organ care
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
CN114375945A (en) 2011-04-14 2022-04-22 特兰斯迈迪茨公司 Organ care solution for ex vivo machine perfusion of donor lungs
FR2974478A1 (en) * 2011-04-28 2012-11-02 Endotis Pharma OLIGOSACCHARIDE CONJUGATES IN PREVENTION OF ISCHEMIA-REPERFUSION LESIONS
WO2013143822A1 (en) 2012-03-26 2013-10-03 Imax Discovery Gmbh Adenosine as sweetness enhancer for certain sugars
AU2015271799B2 (en) 2014-06-02 2019-07-11 Transmedics, Inc. Ex vivo organ care system
WO2016090498A1 (en) 2014-12-12 2016-06-16 Freed Darren Apparatus and method for organ perfusion
IL310004A (en) 2015-09-09 2024-03-01 Transmedics Inc Aortic cannula for ex vivo organ care system
CN106035316B (en) * 2016-04-25 2018-07-31 浙江大学 A kind of Celsior of improvement preserves liquid and preparation method thereof for the heart

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5370989A (en) * 1992-04-03 1994-12-06 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5370989A (en) * 1992-04-03 1994-12-06 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SANDBERG M. ET AL: "Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole-3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells", BIOCHEMICAL JOURNAL, vol. 279, 1991, pages 521 - 527, XP003008527 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844345B2 (en) 2005-06-28 2023-12-19 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US12127554B2 (en) 2023-08-11 2024-10-29 Transmedics, Inc. Apparatus and method for ex vivo lung ventilation with a varying exterior pressure

Also Published As

Publication number Publication date
WO2006060309A2 (en) 2006-06-08

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