WO2006057011A3 - Use of chitosan for stimulating bone healing and bone formation - Google Patents

Use of chitosan for stimulating bone healing and bone formation Download PDF

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Publication number
WO2006057011A3
WO2006057011A3 PCT/IS2005/000025 IS2005000025W WO2006057011A3 WO 2006057011 A3 WO2006057011 A3 WO 2006057011A3 IS 2005000025 W IS2005000025 W IS 2005000025W WO 2006057011 A3 WO2006057011 A3 WO 2006057011A3
Authority
WO
WIPO (PCT)
Prior art keywords
chitosan
bone
stimulating
healing
bone formation
Prior art date
Application number
PCT/IS2005/000025
Other languages
French (fr)
Other versions
WO2006057011A2 (en
Inventor
Michael Silbermann
Johannes Gislason
Jon M Einarsson
Martin Peter
Original Assignee
Genis Ehf
Michael Silbermann
Johannes Gislason
Jon M Einarsson
Martin Peter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genis Ehf, Michael Silbermann, Johannes Gislason, Jon M Einarsson, Martin Peter filed Critical Genis Ehf
Publication of WO2006057011A2 publication Critical patent/WO2006057011A2/en
Publication of WO2006057011A3 publication Critical patent/WO2006057011A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Abstract

A use and a composition based on chitosan are provided for stimulating bone healing and bone formation. Chitosan is demonstrated to be a potent osteoinductor and substantially accelerates new bone formation through the endochondrial ossification pathway, by forming cartilage which is subsequently vascularised and mineralized and transformed into a normal healthy bone tissue.
PCT/IS2005/000025 2004-11-29 2005-11-29 Use of chitosan for stimulating bone healing and bone formation WO2006057011A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IS7572 2004-11-29
IS7572A IS7572A (en) 2004-11-29 2004-11-29 Method and materials for healing

Publications (2)

Publication Number Publication Date
WO2006057011A2 WO2006057011A2 (en) 2006-06-01
WO2006057011A3 true WO2006057011A3 (en) 2006-07-13

Family

ID=36190406

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IS2005/000025 WO2006057011A2 (en) 2004-11-29 2005-11-29 Use of chitosan for stimulating bone healing and bone formation

Country Status (2)

Country Link
IS (1) IS7572A (en)
WO (1) WO2006057011A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
JP2005505351A (en) 2001-10-12 2005-02-24 オステオテック インコーポレーテッド Improved bone graft
EP1638486A4 (en) 2003-06-11 2010-09-29 Osteotech Inc Osteoimplants and methods for their manufacture
WO2007056671A1 (en) * 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
WO2008063791A2 (en) * 2006-10-13 2008-05-29 Ndsu Research Foundation Composites and methods of preparation and use thereof
DE102008019748A1 (en) * 2008-04-18 2009-10-22 Gottfried Wilhelm Leibniz Universität Hannover Bioresorbable material
JP2012506733A (en) 2008-10-24 2012-03-22 ウォーソー・オーソペディック・インコーポレーテッド Compositions and methods for promoting bone formation
IT1396934B1 (en) * 2009-11-25 2012-12-20 Fin Ceramica Faenza Spa COMPOSITE BIO-MIMETIC MATERIALS, RELATED PREPARATION PROCESS AND THEIR USE FOR THE IMPLEMENTATION OF MONO-, BI- OR MULTI-LAYER STRUCTURES FOR THE REGENERATION OF BONE, CARTILAGE OR OSTEOCARTILAGE
MX352422B (en) 2012-04-23 2017-11-24 Genis Hf Self-hardening bioactive cement compositions with partially deacetylated chitin as bone graft substitutes.
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CN107715167A (en) * 2017-09-19 2018-02-23 中国人民武装警察部队后勤学院 Chitosan-based hemostatic paste and preparation method as bone wax substitute
CN115006590B (en) * 2022-06-07 2023-04-14 武汉理工大学 Double-drug-loading slow-release bone repair stent for osteosarcoma postoperative reconstruction

Citations (10)

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Publication number Priority date Publication date Assignee Title
JPS63156726A (en) * 1986-12-19 1988-06-29 Lion Corp Remedy for bone disease
WO2001000792A1 (en) * 1999-06-29 2001-01-04 Marchosky J Alexander Compositions and methods for forming and strengthening bone
US20020082220A1 (en) * 2000-06-29 2002-06-27 Hoemann Caroline D. Composition and method for the repair and regeneration of cartilage and other tissues
KR20020076686A (en) * 2001-03-30 2002-10-11 주식회사 리젠 바이오텍 Composition for stimulating bone-forming and bone-consolidation
KR20020093721A (en) * 2002-11-20 2002-12-16 김세권 Phosphorylated chitosan oligosaccharide with low molecular weight as calcium absorption accelerator
EP1308177A1 (en) * 2000-08-10 2003-05-07 Osfarma, S.L. Method for the production of chitosan-based films with enhanced cell adhering capacity, resulting product and applications
WO2003051376A1 (en) * 2001-12-14 2003-06-26 Ism Biopolymer Inc. Chitosan oligosaccharides and uses thereof
US20030134810A1 (en) * 2001-10-09 2003-07-17 Chris Springate Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents
WO2004028578A1 (en) * 2002-09-30 2004-04-08 Regen Biotech, Inc. Composition for stimulating bone-formation and bone consolidation
WO2004091678A1 (en) * 2003-04-16 2004-10-28 Fti Technologies Gmbh Chitosan film used as a periosteum replacement

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63156726A (en) * 1986-12-19 1988-06-29 Lion Corp Remedy for bone disease
WO2001000792A1 (en) * 1999-06-29 2001-01-04 Marchosky J Alexander Compositions and methods for forming and strengthening bone
US20020082220A1 (en) * 2000-06-29 2002-06-27 Hoemann Caroline D. Composition and method for the repair and regeneration of cartilage and other tissues
EP1308177A1 (en) * 2000-08-10 2003-05-07 Osfarma, S.L. Method for the production of chitosan-based films with enhanced cell adhering capacity, resulting product and applications
KR20020076686A (en) * 2001-03-30 2002-10-11 주식회사 리젠 바이오텍 Composition for stimulating bone-forming and bone-consolidation
US20030134810A1 (en) * 2001-10-09 2003-07-17 Chris Springate Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents
WO2003051376A1 (en) * 2001-12-14 2003-06-26 Ism Biopolymer Inc. Chitosan oligosaccharides and uses thereof
WO2004028578A1 (en) * 2002-09-30 2004-04-08 Regen Biotech, Inc. Composition for stimulating bone-formation and bone consolidation
KR20020093721A (en) * 2002-11-20 2002-12-16 김세권 Phosphorylated chitosan oligosaccharide with low molecular weight as calcium absorption accelerator
WO2004091678A1 (en) * 2003-04-16 2004-10-28 Fti Technologies Gmbh Chitosan film used as a periosteum replacement

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHO B C ET AL: "Effect of calcium sulfate-chitosan composite: Pellet on bone formation in bone defect", JOURNAL OF CRANIOFACIAL SURGERY 2005 UNITED STATES, vol. 16, no. 2, 2005, pages 213 - 224, XP008062997, ISSN: 1049-2275 *
CHO B C ET AL: "The role of hyaluronic acid, chitosan, and calcium sulfate and their combined effect on early bony consolidation in distraction osteogenesis of a canine model", JOURNAL OF CRANIOFACIAL SURGERY 2002 UNITED STATES, vol. 13, no. 6, 2002, pages 783 - 793, XP008062996, ISSN: 1049-2275 *
DATABASE WPI Week 19, 29 June 1988 Derwent World Patents Index; Class 883, Page 2, AN 1988-223011, XP002378695, NAMITA KENJI ET AL.: "Remedy for bone disease" *
DATABASE WPI Week 20, 11 October 2002 Derwent World Patents Index; Class 046, Page 6, AN 2003-154643, XP002378697, CHO BYEONG CHAE ET AL.: "Composite for facilitating osteogenesis and osteosclerosis" *
DATABASE WPI Week 20, 16 December 2002 Derwent World Patents Index; Class 032, Page 9, AN 2003-297156, XP002378696, HYUN B.H. ET AL.: "Low molecular weight phosphorylated chitosan oligosaccharide as calcium absorption accelerating agent" *
IWATA H ET AL: "Effects of chitosan oligosaccharides on the femur trabecular structure in ovariectomized rats", ORAL RADIOLOGY 2005 JAPAN, vol. 21, no. 1, 2005, pages 19 - 22, XP008062990, ISSN: 0911-6028 *
KLOKKEVOLD PERRY R ET AL: "Osteogenesis enhanced by chitosan (poly-N-acetyl glucosaminoglycan) in vitro", JOURNAL OF PERIODONTOLOGY, vol. 67, no. 11, 1996, pages 1170 - 1175, XP008062982, ISSN: 0022-3492 *
YAMADA SHIZUKA ET AL: "Mineralization of matrix vesicles isolated from a human osteosarcoma cell line in culture with water-soluble chitosan-containing medium.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 66A, no. 3, 1 September 2003 (2003-09-01), pages 500 - 506, XP002378691, ISSN: 0021-9304 *

Also Published As

Publication number Publication date
IS7572A (en) 2006-05-30
WO2006057011A2 (en) 2006-06-01

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