WO2006056463A3 - Verfahren zur herstellung von albumin-konjugaten mit nichtsteroidalen antirheumatika (nsar) - Google Patents

Verfahren zur herstellung von albumin-konjugaten mit nichtsteroidalen antirheumatika (nsar) Download PDF

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Publication number
WO2006056463A3
WO2006056463A3 PCT/EP2005/012638 EP2005012638W WO2006056463A3 WO 2006056463 A3 WO2006056463 A3 WO 2006056463A3 EP 2005012638 W EP2005012638 W EP 2005012638W WO 2006056463 A3 WO2006056463 A3 WO 2006056463A3
Authority
WO
WIPO (PCT)
Prior art keywords
nsar
conjugates
albumen
production
antirheumatic drugs
Prior art date
Application number
PCT/EP2005/012638
Other languages
English (en)
French (fr)
Other versions
WO2006056463A2 (de
Inventor
Hannsjoerg Sinn
Marcel Muelbaier
Original Assignee
Albupharm Heidelberg Gmbh & Co
Hannsjoerg Sinn
Marcel Muelbaier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albupharm Heidelberg Gmbh & Co, Hannsjoerg Sinn, Marcel Muelbaier filed Critical Albupharm Heidelberg Gmbh & Co
Priority to CA002589455A priority Critical patent/CA2589455A1/en
Priority to US11/791,584 priority patent/US20080306245A1/en
Priority to EP05813969A priority patent/EP1819363A2/de
Publication of WO2006056463A2 publication Critical patent/WO2006056463A2/de
Publication of WO2006056463A3 publication Critical patent/WO2006056463A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft NSAR (nicht-steroidale Antirheumatika)-Protein-Konjugate und insbesondere NSAR-Albumin-Konjugate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel, insbesondere zur Behandlung von Entzündungen.
PCT/EP2005/012638 2004-11-26 2005-11-25 Verfahren zur herstellung von albumin-konjugaten mit nichtsteroidalen antirheumatika (nsar) WO2006056463A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002589455A CA2589455A1 (en) 2004-11-26 2005-11-25 Process for producing albumin conjugates with non-steroidal antirheumatic agents (nsar)
US11/791,584 US20080306245A1 (en) 2004-11-26 2005-11-25 Method For The Production Of Albumen Conjugates With Non-Steroidal Antirheumatic Drugs (Nsar)
EP05813969A EP1819363A2 (de) 2004-11-26 2005-11-25 Verfahren zur herstellung von albumin-konjugaten mit nichtsteroidalen antirheumatika (nsar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004057196A DE102004057196A1 (de) 2004-11-26 2004-11-26 Verfahren zur Herstellung von Albumin-Konjugaten mit Nicht-steroidalen Antirheumatika (NSAR)
DE102004057196.1 2004-11-26

Publications (2)

Publication Number Publication Date
WO2006056463A2 WO2006056463A2 (de) 2006-06-01
WO2006056463A3 true WO2006056463A3 (de) 2006-07-27

Family

ID=35907990

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/012638 WO2006056463A2 (de) 2004-11-26 2005-11-25 Verfahren zur herstellung von albumin-konjugaten mit nichtsteroidalen antirheumatika (nsar)

Country Status (5)

Country Link
US (1) US20080306245A1 (de)
EP (1) EP1819363A2 (de)
CA (1) CA2589455A1 (de)
DE (1) DE102004057196A1 (de)
WO (1) WO2006056463A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9629920B2 (en) 2009-12-18 2017-04-25 Exodos Life Sciences Limited Partnership Methods and compositions for stable liquid drug formulations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0282057A2 (de) * 1987-03-11 1988-09-14 The Board Of Regents Of The University Of Michigan Chemo-Radio-Immunkonjugate
EP0879604A1 (de) * 1997-05-09 1998-11-25 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Konjugat, umfassend einen Folsäureantagonisten und einen Träger

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9200481A (nl) * 1992-03-13 1993-10-01 Univ Groningen Farmaceutisch preparaat met plaatsgerichte afgifte.
US5849727A (en) * 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0282057A2 (de) * 1987-03-11 1988-09-14 The Board Of Regents Of The University Of Michigan Chemo-Radio-Immunkonjugate
EP0879604A1 (de) * 1997-05-09 1998-11-25 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Konjugat, umfassend einen Folsäureantagonisten und einen Träger

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DAVIS M-T B ET AL: "A SIMPLE MODIFIED CARBODIIMIDE METHOD FOR CONJUGATION OF SMALL MOLECULAR WEIGHT COMPOUNDS TO IMMUNO GLOBULIN G WITH MINIMAL PROTEIN CROSS LINKING", ANALYTICAL BIOCHEMISTRY, vol. 116, no. 2, 1981, pages 402 - 407, XP008061171, ISSN: 0003-2697 *
FRANSSEN E J F ET AL: "HEPATIC AND INTRAHEPATIC TARGETING OF AN ANTI-INFLAMMATORY AGENT WITH HUMAN SERUM ALBUMIN AND NEOGLYCOPROTEINS AS CARRIER MOLECULES", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 45, no. 6, 24 March 1993 (1993-03-24), pages 1215 - 1266, XP002059419, ISSN: 0006-2952 *
FRANSSEN E J F ET AL: "LOW MOLECULAR WEIGHT PROTEINS AS CARRIERS FOR RENAL DRUG TARGETING. PREPARATION OF DRUG-PROTEIN CONJUGATES AND DRUG-SPACER DERIVATIVES AND THEIR CATABOLISM IN RENAL CORTEX HOMOGENATES AND LYSOSOMAL LYSATES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 35, no. 7, 1992, pages 1246 - 1259, XP000651622, ISSN: 0022-2623 *
GHOSH M K ET AL: "PREPARATION AND CHARACTERIZATION OF METHOTREXATE-IMMUNOGLOBULIN CONJUGATES", DRUG DESIGN AND DELIVERY, HARWOOD ACADEMIC PUBLISHERS GMBH, vol. 4, no. 1, 1989, pages 13 - 25, XP000910702 *
HANFELD V ET AL: "Synthesis of phenol-antigen conjugates by reacting N-hydroxysuccinimidic esters of hydroxybenzoic acids with human serum albumin and bovine gamma globulin", PHARMAZIE 1982 GERMANY, vol. 37, no. 7, 1982, pages 479 - 480, XP008061357 *
RAMANJANEYULU R ET AL: "CHEMICAL APPROACH TO ASPIRIN HYPER SENSITIVITY", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 101, no. 1, 1981, pages 258 - 264, XP008061276, ISSN: 0006-291X *
SEAN C SWEETMAN: "Martindale: The Complete Drug Reference, 33th edition", May 2002, PHARMACEUTICAL PRESS, LONDON, UK, XP002371890 *
WUNDER A ET AL: "Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis", JOURNAL OF IMMUNOLOGY 01 MAY 2003 UNITED STATES, vol. 170, no. 9, 1 May 2003 (2003-05-01), pages 4793 - 4801, XP002371816, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
US20080306245A1 (en) 2008-12-11
WO2006056463A2 (de) 2006-06-01
CA2589455A1 (en) 2006-06-01
EP1819363A2 (de) 2007-08-22
DE102004057196A1 (de) 2006-06-01

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