WO2006048275A3 - Chronic lymphocytic leukemia expression profiling - Google Patents

Chronic lymphocytic leukemia expression profiling Download PDF

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Publication number
WO2006048275A3
WO2006048275A3 PCT/EP2005/011751 EP2005011751W WO2006048275A3 WO 2006048275 A3 WO2006048275 A3 WO 2006048275A3 EP 2005011751 W EP2005011751 W EP 2005011751W WO 2006048275 A3 WO2006048275 A3 WO 2006048275A3
Authority
WO
WIPO (PCT)
Prior art keywords
chronic lymphocytic
lymphocytic leukemia
expression profiling
leukemia expression
genotyping
Prior art date
Application number
PCT/EP2005/011751
Other languages
French (fr)
Other versions
WO2006048275A2 (en
Inventor
Torsten Haferlach
Frank Dicker
Martin Dugas
Wolfgang Kern
Alexander Kohlmann
Susanne Schnittger
Claudia Schoch
Original Assignee
Roche Diagnostics Gmbh
Hoffmann La Roche
Torsten Haferlach
Frank Dicker
Martin Dugas
Wolfgang Kern
Alexander Kohlmann
Susanne Schnittger
Claudia Schoch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, Hoffmann La Roche, Torsten Haferlach, Frank Dicker, Martin Dugas, Wolfgang Kern, Alexander Kohlmann, Susanne Schnittger, Claudia Schoch filed Critical Roche Diagnostics Gmbh
Publication of WO2006048275A2 publication Critical patent/WO2006048275A2/en
Publication of WO2006048275A3 publication Critical patent/WO2006048275A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to rapid and reliable approaches to detecting and genotyping chronic lymphocytic leukemia and its subtypes. In addition to methods of genotyping leukemia, the invention also provides related kits and systems.
PCT/EP2005/011751 2004-11-04 2005-11-03 Chronic lymphocytic leukemia expression profiling WO2006048275A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62531204P 2004-11-04 2004-11-04
US60/625,312 2004-11-04

Publications (2)

Publication Number Publication Date
WO2006048275A2 WO2006048275A2 (en) 2006-05-11
WO2006048275A3 true WO2006048275A3 (en) 2006-07-20

Family

ID=35645639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/011751 WO2006048275A2 (en) 2004-11-04 2005-11-03 Chronic lymphocytic leukemia expression profiling

Country Status (1)

Country Link
WO (1) WO2006048275A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002047007A2 (en) * 2000-12-07 2002-06-13 Phase It Intelligent Solutions Ag Expert system for classification and prediction of genetic diseases
WO2003039443A2 (en) * 2001-11-05 2003-05-15 Deutsches Krebsforschungszentrum Novel genetic markers for leukemias
WO2003095650A1 (en) * 2002-05-08 2003-11-20 Bayer Healthcare Ag Human prolyl 4-hydroxylase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002047007A2 (en) * 2000-12-07 2002-06-13 Phase It Intelligent Solutions Ag Expert system for classification and prediction of genetic diseases
WO2003039443A2 (en) * 2001-11-05 2003-05-15 Deutsches Krebsforschungszentrum Novel genetic markers for leukemias
WO2003095650A1 (en) * 2002-05-08 2003-11-20 Bayer Healthcare Ag Human prolyl 4-hydroxylase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GENECARDS [online] "Hypothetical protein FLJ22222", XP002365621, retrieved from HTTP://WWW.GENECARDS.ORG/CGI-BIN/CARDDISP?FLJ22222&SEARCH=FLJ22222&SUFF=TXT Database accession no. FLJ22222 *
HAFERLACH T ET AL: "The Diagnosis of 14 Specific Subtypes of Leukemia Is Possible Based on Gene Expression Profiles: A Study on 263 Patients with AML, ALL, CML, or CLL", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 100, no. 11, 16 November 2002 (2002-11-16), pages 139A, XP002263227, ISSN: 0006-4971 *
KIENLE DIRK L ET AL: "Evidence for distinct pathomechanisms in genetic subgroups of chronic lymphocytic leukemia revealed by quantitative expression analysis of cell cycle, activation, and apoptosis-associated genes.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY. 1 JUN 2005, vol. 23, no. 16, 1 June 2005 (2005-06-01), pages 3780 - 3792, XP009060893, ISSN: 0732-183X *
KOHLMANN ALEXANDER ET AL: "Gene Expression Profiles of Distinct Cytogenetic CLL Subtypes.", BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), & 44TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; PHILADELPHIA, PA, USA; DECEMBER 06-10, 2002, pages Abstract No. 629, XP009060933, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
WO2006048275A2 (en) 2006-05-11

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