WO2006048265A3 - Classifying leukemia with translocation (9;22) - Google Patents

Classifying leukemia with translocation (9;22) Download PDF

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Publication number
WO2006048265A3
WO2006048265A3 PCT/EP2005/011731 EP2005011731W WO2006048265A3 WO 2006048265 A3 WO2006048265 A3 WO 2006048265A3 EP 2005011731 W EP2005011731 W EP 2005011731W WO 2006048265 A3 WO2006048265 A3 WO 2006048265A3
Authority
WO
WIPO (PCT)
Prior art keywords
translocation
leukemia
classifying
classifying leukemia
rapid
Prior art date
Application number
PCT/EP2005/011731
Other languages
French (fr)
Other versions
WO2006048265A2 (en
WO2006048265A8 (en
Inventor
Torsten Haferlach
Martin Dugas
Wolfgang Kern
Alexander Kohlmann
Susanne Schnittger
Claudia Schoch
Original Assignee
Roche Diagnostics Gmbh
Hoffmann La Roche
Torsten Haferlach
Martin Dugas
Wolfgang Kern
Alexander Kohlmann
Susanne Schnittger
Claudia Schoch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, Hoffmann La Roche, Torsten Haferlach, Martin Dugas, Wolfgang Kern, Alexander Kohlmann, Susanne Schnittger, Claudia Schoch filed Critical Roche Diagnostics Gmbh
Priority to EP05806746A priority Critical patent/EP1815012A2/en
Publication of WO2006048265A2 publication Critical patent/WO2006048265A2/en
Publication of WO2006048265A3 publication Critical patent/WO2006048265A3/en
Publication of WO2006048265A8 publication Critical patent/WO2006048265A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to rapid and reliable approaches to detecting and classifying leukemia. In addition to these methods, the invention also provides related kits and systems.
PCT/EP2005/011731 2004-11-04 2005-11-03 Classifying leukemia with translocation (9;22) WO2006048265A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05806746A EP1815012A2 (en) 2004-11-04 2005-11-03 Classifying leukemia with translocation (9;22)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62537504P 2004-11-04 2004-11-04
US60/625,375 2004-11-04

Publications (3)

Publication Number Publication Date
WO2006048265A2 WO2006048265A2 (en) 2006-05-11
WO2006048265A3 true WO2006048265A3 (en) 2006-09-21
WO2006048265A8 WO2006048265A8 (en) 2007-05-24

Family

ID=36017604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/011731 WO2006048265A2 (en) 2004-11-04 2005-11-03 Classifying leukemia with translocation (9;22)

Country Status (2)

Country Link
EP (1) EP1815012A2 (en)
WO (1) WO2006048265A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414133B1 (en) * 1998-10-13 2002-07-02 Ventana Medical Systems, Inc. Multiple fusion probes
WO2003008552A2 (en) * 2001-07-17 2003-01-30 Whitehead Institute For Biomedical Research Mll translocations specify a distinct gene expression profile, distinguishing a unique leukemia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414133B1 (en) * 1998-10-13 2002-07-02 Ventana Medical Systems, Inc. Multiple fusion probes
WO2003008552A2 (en) * 2001-07-17 2003-01-30 Whitehead Institute For Biomedical Research Mll translocations specify a distinct gene expression profile, distinguishing a unique leukemia

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ARMSTRONG S A ET AL: "MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 30, no. 1, January 2002 (2002-01-01), pages 41 - 47, XP002276635, ISSN: 1061-4036 *
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; PHILADELPHIA, PA, USA; DECEMBER 06-10, 2002, pages Abstract No. 1212, ISSN: 0006-4971 *
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; PHILADELPHIA, PA, USA; DECEMBER 06-10, 2002, pages Abstract No. 523, ISSN: 0006-4971 *
BLOOD, vol. 104, no. 11, Part 1, November 2004 (2004-11-01), 46TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; SAN DIEGO, CA, USA; DECEMBER 04 -07, 2004, pages 430A, ISSN: 0006-4971 *
BLOOD, vol. 98, no. 11 Part 2, 16 November 2001 (2001-11-16), 43RD ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY, PART 2; ORLANDO, FLORIDA, USA; DECEMBER 07-11, 2001, pages 162b, ISSN: 0006-4971 *
BUNO I ET AL: "A special fluorescent in situ hybridization technique to study peripheral blood and assess the effectiveness of interferon therapy in chronic myeloid leukemia", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 92, no. 7, 1 October 1998 (1998-10-01), pages 2315 - 2321, XP002243268, ISSN: 0006-4971 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2001 (2001-11-16), MERGENTHALER SUSANNE ET AL: "Expression profiling using microarrays in t(9;22) positive acute lymphoblastic and chronic myeloid leukemias: Differences and similarities in 10 patients", XP002373952, Database accession no. PREV200200152037 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), HAFERLACH TORSTEN ET AL: "The Diagnosis of 14 Specific Subtypes of Leukemia Is Possible Based on Gene Expression Profiles: A Study on 263 Patients with AML, ALL, CML, or CLL.", XP002373784, Database accession no. PREV200300356464 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "Functionally Annotated Gene Expression Profiles of t(9;22) Positive CML and ALL.", XP002373782, Database accession no. PREV200300335812 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; November 2004 (2004-11-01), KOHLMANN ALEXANDER ET AL: "Transcriptional profiling identifies genes differentially regulated by the BCR/ABL fusion oncogene", XP002373783, Database accession no. PREV200510269509 *
DATABASE GENEANNOT Weizmann Institute of Science; XP002373953 *
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
WO2006048265A2 (en) 2006-05-11
WO2006048265A8 (en) 2007-05-24
EP1815012A2 (en) 2007-08-08

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