WO2006047167A3 - 9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials - Google Patents

9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials Download PDF

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Publication number
WO2006047167A3
WO2006047167A3 PCT/US2005/037570 US2005037570W WO2006047167A3 WO 2006047167 A3 WO2006047167 A3 WO 2006047167A3 US 2005037570 W US2005037570 W US 2005037570W WO 2006047167 A3 WO2006047167 A3 WO 2006047167A3
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WIPO (PCT)
Prior art keywords
alkyl
alkylidenyl
antimicrobials
ketolide
carbamate
Prior art date
Application number
PCT/US2005/037570
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French (fr)
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WO2006047167A2 (en
Inventor
Eugene B Grant Iii
Original Assignee
Janssen Pharmaceutica Nv
Eugene B Grant Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv, Eugene B Grant Iii filed Critical Janssen Pharmaceutica Nv
Publication of WO2006047167A2 publication Critical patent/WO2006047167A2/en
Publication of WO2006047167A3 publication Critical patent/WO2006047167A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

9-Alkyl- and 9-alkylidenyl-6-O-alkyl-11,12-carbamate-ketolide and 9-alkylidene-6-O-alkyl-11,12-carbamate-ketolide antimicrobials of the Formula: wherein Ra, Rb, Rc R, L, T, Y, and Z are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
PCT/US2005/037570 2004-10-21 2005-10-19 9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials WO2006047167A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97080504A 2004-10-21 2004-10-21
US10/970,805 2004-10-21

Publications (2)

Publication Number Publication Date
WO2006047167A2 WO2006047167A2 (en) 2006-05-04
WO2006047167A3 true WO2006047167A3 (en) 2007-03-01

Family

ID=36228239

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Application Number Title Priority Date Filing Date
PCT/US2005/037570 WO2006047167A2 (en) 2004-10-21 2005-10-19 9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials

Country Status (1)

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WO (1) WO2006047167A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7622452B2 (en) 2006-11-16 2009-11-24 Enanta Pharmaceuticals, Inc. C-9 alkenylidine bridged macrolides
WO2008062878A1 (en) * 2006-11-22 2008-05-29 Nihon Nohyaku Co., Ltd. Novel pyrazole derivative, harmful organism control agent, and use of the control agent
GB201401198D0 (en) 2014-01-24 2014-03-12 Bial Portela & Ca Sa Process for the syntheis of substituted urea compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169168B1 (en) * 1997-10-29 2001-01-02 Taisho Pharmaceuticals Co., Ltd. Erythromycin A derivatives
EP1310506A1 (en) * 2000-08-14 2003-05-14 Taisho Pharmaceutical Co., Ltd Process for producing erythromycin derivative
WO2003042228A1 (en) * 2001-11-14 2003-05-22 Glaxo Group Limited Macrolides
US6774115B1 (en) * 2003-06-05 2004-08-10 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic ketolides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169168B1 (en) * 1997-10-29 2001-01-02 Taisho Pharmaceuticals Co., Ltd. Erythromycin A derivatives
EP1310506A1 (en) * 2000-08-14 2003-05-14 Taisho Pharmaceutical Co., Ltd Process for producing erythromycin derivative
WO2003042228A1 (en) * 2001-11-14 2003-05-22 Glaxo Group Limited Macrolides
US6774115B1 (en) * 2003-06-05 2004-08-10 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic ketolides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GRANT E B ET AL: "The synthesis of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their ketolides", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 16, 18 April 2005 (2005-04-18), pages 2731 - 2735, XP004817766, ISSN: 0040-4039 *
HAUSKE J.R. ET AL.: "Aglycon Modifications of Erythromycin A and Erythromycin B: Regiospecific Nucleophilic Ring Openig of Cylic Thionocarbonates", JOURNAL OF ORGANIC CHEMISTRY, vol. 48, 1983, pages 5138 - 5140, XP002404688 *

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Publication number Publication date
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