WO2006046108A2 - Diagnostic de l'infertilite masculine par dosage de l'inhibiteur de la voie du facteur tissulaire - Google Patents

Diagnostic de l'infertilite masculine par dosage de l'inhibiteur de la voie du facteur tissulaire Download PDF

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Publication number
WO2006046108A2
WO2006046108A2 PCT/IB2005/003172 IB2005003172W WO2006046108A2 WO 2006046108 A2 WO2006046108 A2 WO 2006046108A2 IB 2005003172 W IB2005003172 W IB 2005003172W WO 2006046108 A2 WO2006046108 A2 WO 2006046108A2
Authority
WO
WIPO (PCT)
Prior art keywords
tfpi
sample
semen
sperm
kit
Prior art date
Application number
PCT/IB2005/003172
Other languages
English (en)
Other versions
WO2006046108A3 (fr
Inventor
Bashir Lwaleed
Alan Cooper
Robert Greenfield
Original Assignee
American Diagnostica Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Diagnostica Inc. filed Critical American Diagnostica Inc.
Publication of WO2006046108A2 publication Critical patent/WO2006046108A2/fr
Publication of WO2006046108A3 publication Critical patent/WO2006046108A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8114—Kunitz type inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction

Definitions

  • TFPI binds to FXa via its Kunitz domain 2
  • TFPI/FXa complex binds to the TF/FVIIa complex via its Kunitz domain 1, forming an inactive quaternary TFPI/FXa/TF/FVIIa complex.
  • F Factor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Le sperme humain contient du facteur tissulaire (TF, Thromboplastine, CD142) et un inhibiteur naturel de la voie dépendante du TF, l'inhibiteur de la voie du facteur tissulaire (TFPI), présent dans le plasma séminal, le sperme sélectionné par migration ascendante (swim-up) et les prostasomes. On a constaté que les taux de TFPI étaient significativement plus élevés chez les hommes normaux que chez les sujets présentant une hypofertilité (p<0,01), ou chez les sujets vasectomisés (p<0,001). La présente invention concerne une méthode de diagnostic pratiquée in vitro, consistant à obtenir un échantillon de sperme d'un sujet mâle et à mesurer le taux de TFPI qu'il contient. Ce taux est ensuite comparé à un niveau de référence. Une valeur mesurée se situant en dessous du niveau de référence indique un faible niveau de fécondité chez le sujet. Une trousse de matériel permettant la mise en oeuvre de cette méthode de diagnostic est également décrite.
PCT/IB2005/003172 2004-10-26 2005-10-24 Diagnostic de l'infertilite masculine par dosage de l'inhibiteur de la voie du facteur tissulaire WO2006046108A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62216604P 2004-10-26 2004-10-26
US60/622,166 2004-10-26

Publications (2)

Publication Number Publication Date
WO2006046108A2 true WO2006046108A2 (fr) 2006-05-04
WO2006046108A3 WO2006046108A3 (fr) 2006-07-20

Family

ID=36228150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003172 WO2006046108A2 (fr) 2004-10-26 2005-10-24 Diagnostic de l'infertilite masculine par dosage de l'inhibiteur de la voie du facteur tissulaire

Country Status (1)

Country Link
WO (1) WO2006046108A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010049340A1 (fr) * 2008-10-28 2010-05-06 Justus-Liebig-Universität Giessen Test immunologique destiné à détecter des auto-anticorps dirigés contre des antigènes testiculaires
WO2012021969A1 (fr) 2010-08-16 2012-02-23 Mount Sinai Hospital Marqueurs du tractus urogénital mâle
US9097054B2 (en) 2009-11-13 2015-08-04 University Of Central Florida Research Foundation, Inc. Implementation of on-off passive wireless surface acoustic wave sensor using coding and switching techniques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187200A1 (en) * 1997-01-31 2003-10-02 Human Genome Sciences, Inc. Tissue factor pathway inhibitor-3

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187200A1 (en) * 1997-01-31 2003-10-02 Human Genome Sciences, Inc. Tissue factor pathway inhibitor-3

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
THYZEL E.: 'Decreased TFPI Levels in Seminal Plasma of Infertile Men' CLINICAL CHEMISTRY vol. 49, no. 6, SUPPLEMENT, June 2003, pages A3 - A4, XP008070468 *
THYZEL E.: 'Quantification of Tissue Factor Pathway Inhibitor in Human Seminal Plasma and in Human Follicular Fluid' THROMBOSIS RESEARCH vol. 109, no. 5-6, 15 March 2003, pages 329 - 332, XP003001708 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010049340A1 (fr) * 2008-10-28 2010-05-06 Justus-Liebig-Universität Giessen Test immunologique destiné à détecter des auto-anticorps dirigés contre des antigènes testiculaires
CN102292639A (zh) * 2008-10-28 2011-12-21 尤斯图斯-李比希-吉森大学 检测抗睾丸抗原自身抗体的免疫测试
JP2012507024A (ja) * 2008-10-28 2012-03-22 ユストゥス−リービッヒ−ウニヴェルジテート・ギーセン 精巣抗原に対する自己抗体検出のための免疫検査
US8557606B2 (en) 2008-10-28 2013-10-15 Justus-Liebig-Universitat Giessen Immunological test for detecting autoantibodies against testicular antigens
RU2528060C2 (ru) * 2008-10-28 2014-09-10 Юстус-Либиг-Университет Гиссен Иммунологический тест для определения аутоантител против антигенов семенников
CN102292639B (zh) * 2008-10-28 2014-11-12 尤斯图斯-李比希-吉森大学 检测抗睾丸抗原自身抗体的免疫测试
US9097054B2 (en) 2009-11-13 2015-08-04 University Of Central Florida Research Foundation, Inc. Implementation of on-off passive wireless surface acoustic wave sensor using coding and switching techniques
WO2012021969A1 (fr) 2010-08-16 2012-02-23 Mount Sinai Hospital Marqueurs du tractus urogénital mâle
EP2606165A1 (fr) * 2010-08-16 2013-06-26 Mount Sinai Hospital Marqueurs du tractus urogénital mâle
EP2606165A4 (fr) * 2010-08-16 2014-02-26 Mount Sinai Hospital Corp Marqueurs du tractus urogénital mâle
US9040464B2 (en) 2010-08-16 2015-05-26 Mount Sinai Hosptial Markers of the male urogenital tract
US10006921B2 (en) 2010-08-16 2018-06-26 Sinai Health System Markers of the male urogenital tract

Also Published As

Publication number Publication date
WO2006046108A3 (fr) 2006-07-20

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