CLAIMS:
1. A method of inhibiting intimal thickening by administering to a subject in need thereof an inhibitor of TGFb type I receptor or Alk4.
2. The method of claim 1, wherein the inhibitor has the structure shown in formula I:
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein
R1"1 is aryl, heteroaryl, aralkyl, or heteroaralkyl; each Rτ"a is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thioxirea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsxilfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
X1-1 is cycloalkyl or heterocycloalkyl;
Yi-1 is a bond, -C(O)-, -C(O)-O-, -O-C(O)-, -S(O)P-O-, -O-S(O)P-, -C(O)-N(Rb)-, -N(Rb)-C(O)-, -0-C(0)-N(Rb)-, -N(Rb)-C(O)-O-, -O-S(O)p-N(Rb)-, -N(Rb)- S(O)P-O-, -N(Rb)-C(0)-N(Rc)-, -N(Rb)-S(0)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb)-C(O)-, -C(0)-N(Rb)-S(0)p-N(Rc)-, -C(0)-O-S(0)p-N(Rb)-, -N(Rb)-S(0)p-N(Rc)-C(0)-, -N(Rb)-S(O)p-O-C(O)-, -S(O)p-N(Rb)-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)P-, -O-, -S-, or -(C(Rb)(Rc))q-, wherein each of Rb and Rc is independently hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; wherein p is 1 or 2 and q is 1-4;
R1"2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heferocycloallcenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl; each of A1"1 and A1"2, independently, is O, S, N, or NRb, provided that at least one of A1"1 and A1"2 is N; and m is 0, 1, 2, or 3, and when m >2, two adjacent R!"a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety.
3. The method of claim 1, wherein the inhibitor has the structure shown in formula II:
or a pharmaceutically acceptable salt or N-oxide thereof, wherein each OfXn
-1, X11-2, X11-3, and Xn
-4 is independently CR
X or N, provided that no more than two of Xπ-i, X11-2, Xn
-3, and Xn
-4 can be N simultaneously; each Of Yn
-1 and Yn
-2 is independently CR
y or N, provided that at least one of Y
n-1 and Yn
-2 must be N; each R
11"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocyclo alkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaxyloxy, heteroarylsulfanyl, or heteroaroyl; each R
11"2 is independently alkyl, alkenyl, alkynyl, acyl, halo, hydroxy, -NH
2, - NH(alkyl), -N(alkyl)
2, -NH(cycloalkyl), -N(alkyl)(cycloalkyl), -NH(heterocycloalkyl), - NH(heteroaryl),
-NH-alkyl-heterocycloalkyl, -NH-alkyl-heteroaryl, -NH(aralkyl), cycloalkyl, (cycloalkyl)alkyl, aryl, aralkyl, aroyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heteroaryl, heteroaralkyl, heteroaroyl, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkoxy, cycloalkyloxy, cycloalkyl-alkoxy, aryloxy, arylalkoxy, heterocycloalkyloxy, (heterocycloalkyl)alkoxy, heteroaryloxy, heteroarylalkoxy, alkylsulfanyl, cycloalkylsulfanyl, (cycloalkyl)alkylsulfanyl, arylsulfanyl, aralkylsulfanyl, heterocycloalkylsulfanyl, (heterocycloalkyl)alkylsulfanyl, heteroarylsulfanyl, heteroarylalkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, aminosulfonyl, alkylcarbonylamino, cycloalkylcarbonylamino, (cyeloalkytyalkylcarbonylamino, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalky^carbonylamino, (heterocycloalkytyalkylcarbonylarnino, heteroarylcarbonylamino, heteroaralkylcarbonylamino, alkoxycarbonylaminoalkylamino, (heteroaryl)arylcarbonylaminoalkylamino, heteroaralkylcarbonylaminoalkylamino, (heteroarytyarylsulfonylaminoalkylcarbonylaminoalkylammo, arylsulfonylaminoalkylamioo, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, or carbamoyl; m is 0, 1, 2, 3, or 4, and when m Ξ≥2, two adjacent R1 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; n is 0, 1, 2, or 3, and when n >2, two adjacent R2 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; and each of Rx and Ry is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, cycloalkylcarbonyl, (cycloalkyl)alkylcarbonyl, aroyl, aralkylcarbonyl, heterocycloalkylcarbonyl, (heterocycloalkyl)acyl, heteroaroyl, (heteroaryl)acyl, aminocarbonyl, alkylcarbonylamino, (amino)aminocarbonyl, alkylsulfonylaminocarbonyl, alkylsulfonylamino, cycloalkylcarbonylamino, cycloalkylsulfonylamino, (cycloalkyl)alkylcarbonylamino, (cycloalkyl)alkylsulfonylamino ., arylcarbonylamino, arylsulfonylamino, aralkylcarbonylamino, aralkylsulfonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkyl)sulfonylamino, (heterocycloalkyl)alkylcarbonylamino, (heterocycloalkyl)alkylsulfonylainino, heteroarylcarbonylamino, heteroarylsulfonylamino, heteroaralkylcarbonylamino, heteroaralkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfaanide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, (cycloalkyl)alkyl, (cycloalkyl)alkoxy, (cycloalkyl)alkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, (heterocycloalkyl)alkyl, (heterocycloalkyl)alkoxy, (heterocycloalkyl)alkylsulfanyl, aryl, aryloxy, arylsulfanyl, aralkyl, aralkyloxy, aralkylsulfanyl, arylalkenyl, arylalkynyl, heteroaryl, heteroaryloxy, heteiOarylsulfanyl, heteroaralkyl, (heteroaryl)alkoxy, or (heteroaryl)alkylsulfanyl.
4. Trie method of claim 1, wherein the inhibitor has the structure shown in formula III
or a pharmaceutically acceptable salt or N-oxide thereof, wherein each of Xm-I, Xm-2, X111-3, and Xm-4 is independently CRIπ"x or NT, provided that no more than two of Xm-1, Xm-2, Xin-3, and Xm-4 can be N simultaneously; each of Ym-i and Ym-2 is independently CRπi"y or N, provided that at least one OfYm-1 and Ym-2 must be N; each R111"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocyclo alkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, iαeteroaryloxy, heteroarylsulfanyl, or heteroaroyl; each R111"2 is independently alkyl, alkenyl, alkynyl, acyl, halo, hydroxy, -NH2, -NH(alkyl), -N(alkyl)2, -NH(cycloalkyl), -N(alkyl)(cyclocalkyl), -NHOieterocycloalkyl), -NH(heteroaryl), -NH-alkyl-lieterocycloalkyl, -NH-alkyl-heteroaryl, -NH(aralkyl), cycloalkyl, (cycloalkyl)alkyl, aryl, aralkyl, aroyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heteroaryl, heteroaralkyl, heteroaroyl, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkoxy, cycloalkyloxy, (cycloalkyl)alkoxy, aryloxy, arylalkoxy, heterocycloalkyloxy, (heterocycloalkyl)alkoxy, heteroaryloxy, heteroarylalkoxy, alkylsulfanyl, cycloalkylsulfanyl, (cycloalkyl)alkylsulfanyl, arylsulfanyl, aralkylsulfanyl, heterocycloalkylsulfanyl, (heterocycloalkyl)alkylsulfanyl, heteroarylsulfanyl, heteroarylalkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, anxinosulfonyl, alkylcarbonylamino, cycloalkylcaxbonylamino, (cycloalky^alkylcarbonylamino, arylcarbonylamino, aralkylcarboriylamino, (heterocycloalky^carbonylarnino, (heterocycloaUcyl)alkylcarbonylarnino, heteroarylcarbonylamino, heteroafalkylcarbonylamino, alkoxycarbonylaminoalkylamino, (heteroaryl)arylcarbonylaminoalkylamino, lαeteroaralkylcarbonylaminoalkylamino, (heteroary^arylsulfonylaminoalkylcarbonylaminoalkylamino, arylsulfonylaminoaUkylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, or carbamoyl; m is 0, 1, 2, 3, or 4, and when m >2, two adjacent R111"1 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety;
TTT O n is 0, 1, 2, or 3, and when n Ξ≥2, two adjacent R " groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; and each of Riπ"x and Riπ"y is independently hydrogen, alkyl, alkenyl, alkynyl, aLkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsuliϊnyl, alkylsulfonyl, cycloalkylcarbonyl, (cycloalkyl)alkylcarbonyl, aroyl, aralkylcarbonyl, heterocycloalkylcarbonyl, (heterocycloalkyl)acyl, heteroaroyl, (heteroaryl)acyl, aminocarbonyl, alkylcarbonylamino, (amino)aminocarbonyl, alkylsulfonylaminocarbonyl, alkylsulfonylamino, cycloalkylcarbonylamino, cycloalkylsulfonylamino, (cycloaUcyl)alkylcarbonylamino, (cycloalkyl)alkylsulfonylamino, arylcarbonylamino, arylsulfonylamino, aralkylcarbonylamino, aralkylsulfonylaminσ, (heterocycloalky^carbonylamino, (heterocycloalkyl)sulfonylamino, (heterocycloalky^alkylcarbonylamino, (heterocycloalky^alkylsulfonylamino, heteroarylcarbonylamino, heteroarylsulfonylamino, heteroaralkylcarbonylamino, heteroaralkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, (cycloalkyl)alkyl, (cycloaUcyl)alkoxy, (cycloalkyl)alkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, (heterocycloalkyl) alkyl, (heterocycloalkyl)alkoxy, (heterocycloalkyl)alkylsulfanyl, aryl, aryloxy, arylsulfanyl, aralkyl, aralkyloxy, aralkylsulfanyl, arylalkenyl, arylalkynyl, heteroaryl, heteroaryloxy, heteroarylsulfaαyl, heteroaralkyl, (heteroaryl)alkoxy, or (heteroaryl)alkylsulfanyl.
5. The method of claim 1, wherein the inhibitor has the structure shown in formula IV
or an N-oxide or a. pharmaceutically acceptable salt thereof, wherein each RIV"a is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamirio, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocyclo alkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
RWA is a bond, alkylene, alkenylene, alkynylene, or -(CH2)rl-O-(CH2)r2-, wherein each of rl andr2 Is independently 2 or 3;
Rw~2 is cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, or a bond;
R^3 is -C(O)-, -C(O)O-, -OC(O)-, -C(O)-N(R1^)-, -N(R1^)-C(O)-, -0-C(O)-N(R^" b)-, -N(R1^)-C(O)-O-, -0-S(O)P-N(R^'13)-, -N(RIV'b)- S(O)P-O-, -N(RIV"b)-C(O)-N(RIV"c)-, _N(RIV-b)-S(0)p-N(RIV-b)-3 -C(O)-N(Rw-b)-S(O)p-, -S(O)P-N(R1^)-C(O)-, -S(OVNCR1^)-, -N(R^)-S(O)P-, -N(R^-13)-, -S(O)P-, -O-, -S-, or -(C(RIV-b)(RIV-c))q-, or a bond; wherein each of Rw"b and R^"0 is independently hydrogen, hydroxy, alkyl, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; wherein p is 1 or 2 and q is 1-4;
Rw'4 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, aryl, aralkyl, heteroaryl, or heteroaraLkyl;
R™'5 is hydrogen, unsubstituted alkyl, halo-substituted alkyl, alkoxy, alkylsulfinyl, amino, alkenyl, alkynyl, cycloalkyl, cycloalkoxy, cycloalkylsulfinyl, heterocycloalkyl, heterocycloalkoxy, heterocycloalkylsulfinyl, aryl, aryloxy, arylsulfinyl, heteroaryl, heteroaryloxy, or heteroarylsulfmyl; j^rv-6 -s ^ a ^_ tQ 5_rnemiDered heterocyclyl containing 1-3 hetero ring atoms selected from the group consisting of -O-, -S-, -N=, and -NR^- wherein R^ is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroaralkyl; said heterocyclyl being substituted with R^"6 and optionally substituted with one to two Rw"f; wherein Rw'e is oxo, thioxo, alkoxy, alkylsulfinyl, -NH2, -NH(unsubstituted alkyl), or -N(unsubstituted alkyl)2, and R^" is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfbnyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; or
(2) a fused ring heteroaryl selected from the group consisting of:
wherein ring A is an aromatic ring containing 0-4 hetero ring atoms, and ring B is a 5- to 7- membered aromatic or nonaromatic ring containing 0-4 hetero ring atoms, provided that at least one of ring A and ring B contains one or more hetero ring atoms; ring A' is an aromatic ring containing 0-4 hetero ring atoms, and ring B' is a 5- to 7-membered saturated or unsaturated ring containing 0-4 hetero ring atoms, provided that at least one of ring A' and ring B' contains one or more hetero ring atoms; each hetero ring atom is -O-, -S-, -N=, or - NR
1^-; each X
1 is independently N or C; each X
2 is independently -O- -S-, -N=, -NR™
"8- , or -CHR™
"11-; wherein R
W'B is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylallcyl, heteroaryl, or heteroaralkyl; each of R^
"11 and R^
'1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloaϊkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, hetero aryloxy, heteroarylsulfanyl, or tieteroaroyl; and n is 0-2; and m is 0-3, and when m >2, two adjacent R
w'& groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; provided that if R
w~6 is 2-naphthyridinyl, 4-quinolinyl, imidazo[l,2-a]pyridyl, or benzimidazolyl, then -R^'-R^-R^-R™
'4 is not H, unsubstituted a,lkyl, -CH
2-C(O)-N(H)-alkyl, -CH
2-C(O)-N(alkyl)
2, or benzyl.
6. The method of claim 1, wherein the inhibitor has the structure shown in formula V
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein
Rv"! is heteroaryl; each Rv"a, independently, is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, ar;ylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
Xv is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or a bond;
Yv is a bond, -C(O)-, -C(O)-O-, -0-C(O)-, -S(O)P-O-, -O-S(O)P-, -C(0)-N(Rb)-, -N(Rb)-C(0)-, -O-C(O)-N(Rb)-, -N(Rb)-C(0)-0-, -C(0)-N(Rb)-0-, -O-N(Rb)-C(0)-, -O-S(O)p-N(Rb)-, -N(Rb)- S(O)p-O-, -S(O)p-N(Rb)-O-, -O-N(Rb)-S(O>p-, -N(Rb)-C(0)-N(Rc)-, -N(Rb)-S(O)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb)-C(O)-, -C(O>)-N(Rb)-S(O)p-N(Rc)-, -C(Oj-O-S(O)P-N(R")-, -N(Rb)-S(O)p-N(Rc)-C(O>, -N(Rb)-S(O)p-O-C(O)-, -S(O)p-N(Rb)-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)P-, -O-, -S-, or -(C(Rb)(Rc))o wherein each of Rb and Rc, independently, is hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; wherein p is 1 or 2 and q is 1-4;
Rv~2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkeayl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl; each of Av"! and Av~2, independently, is N or NRb; and m is 0, 1, 2, or 3, and when m >2, two adjacent R v"a groups can optionally join together to form a 4- to 8-membexed optionally substituted cyclic moiety, provided that if Xv is a bond, then Yv is a bond; Rv"2 is hydrogen or alkyl; m is 1, 2, or 3; and at least one Rv"a is substituted at the 2-pyrimidinyl position.
7. The method of claim 1, wherein the inhibitor has the structure shown in formula VI:
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein each RVI"a, independently, is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, - NH2, -NH(unsubstituted alkyl), -N(unsubstituted alkyl)2, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfmyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
RVM is a bond, alkylene, alkenylene, alkynylene, or -(CH2)rl-O-(CH2)r2-, where each of rl and r2, independently, is 2 or 3;
RVI~2 is cycloalkylene, heterocycloalkylene, cycloalkenylene, heterocycloalkenylene, arylene, heteroarylene, or a bond;
RVI"3 is -C(O)-, -C(O)-O-, -O-C(O)-, -S(OVO-, -O-S(O)P-, -C(O)-N(Rb)-, -N(Rb)-C(O)-, -O-C(O)-N(Rb)-, -N(Rb)-C(0)-0-, -C(O)-N(Rb)-O-, -O-N(Rb)-C(O)-, -O-S(O)p-N(Rb)-,
-N(Rb)- S(O)p-O-, -S(O)p-N(Rb)-O-, -0-N(Rb)-S(O)p-, -N(Rb)-C(O)-N(Rc)-, -N(Rb)-S(O)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb)-C(O>, -C(O)-N(Rb)-S(O)p-N(Rc)-, -C(O)-O-S(O)p-N(Rb)-, -N(Rb)-S(O)p-N(Rc)-C(O)-, -N(Rb)-S(O)p-O-C(O)-, -S(O)p-N(Rb)-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)P-, -O-, -S-, -(C(Rb)(Rc))q-, or a bond; wherein each of Rb and Rc is independently hydrogen, hydroxy, alkyl, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; wherein p is 1 or 2 and q is 1-4; RVM is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl;
RVI"5 is hydrogen, unsubstituted alkyl, halo-substituted alkyl, alkoxy, alkylsulfinyl, amino, alkenyl, alkynyl, cycloalkoxy, cyclo alkylsulfinyl, heterocycloalkoxy, heterocycloalkylsulfinyl, aryloxy, arylsulfmyl, heteroaryloxy, or heteroarylsulfinyl;
RVI"6 is a 5- to 6-membered monocyclic heterocyclyl or a 8- to 11-membered bicyclic heteroaryl; each being optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; and m is 0-3, and when m >2, two adjacent RVI~a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety.
8. The method of claim 1, wherein the inhibitor is
1) 4-(4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl)-piperidine-l- carboxylic acid benzyl ester;
2) 4-(4-Benzo[ 1 ,3]dioxol-5-yl-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidine- 1 -carboxylic acid benzyl ester;
3) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
4) 3 -[4-B enzo [1,3] dioxol-5 -yl-5 -(6-methyl-pyridin-2-yl)- 1 H-imidazol-2-yl] -pyrrolidine- 1 - carboxylic acid benzyl ester; 5) 2-(5-Benzo[l53]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-6-methyl-pyridine;
6) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid benzyl ester;
7) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
8) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]-pyrrolidine-l- carboxylic acid benzyl ester; 9) 2-(5-Benzo[l ,3] dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-6-methyl-pyridine;
10) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl]-6-methyl-pyridine;
11) 2-[5-Benzo[ 1 ,3 ]dioxol-5-yl-2-( 1 -phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl]-pyridine;
12) 2- [ 5 -B enzo [1,3] dioxol- 5-yl-2-( 1 -methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl] - pyridine;
13) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
14) 4-(4-Benzo[ 1 ,3 ] dioxol-5-yl-5 -pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid 2-chloro-benzyl ester;
15) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 2,4-dichloro-b enzylamide;
16) l-[4-(4-Benzo[ l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-l-yl]- ethanone;
17) 2-[5-Benzo[l,3 ]dioxol-5-yl-2-(l-furan-2-yl-methyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
18) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-cyclohexyl}- carbamic acid benzyl ester;
19) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl] cyclohexylamine ;
20) N- {4-[4-Benzo [ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexyl } -C-phenyl-methanesulfonamide;
21) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid methyl ester;
22) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2]octane- 1 -carboxylic acid;
23) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-carbamic acid benzyl ester;
24) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-ethyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
25) 2-(5-Benzo[l ,3] dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-pyridine;
26) 4-(4-Benzo[l33]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-nitro-benzyl ester; 27) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4,5-dimethoxy-2-nitro-benzyl ester;
28) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyriciin-2-yl-lH-imidazol-2-yl)-piperidme-l-carboxylic acid 3-fluoro-benzylamide;
29) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-fluoro-benzylamide;
30) 4-(4-Benzo [ 1 ,3 ]dioxol-5-yl-5 -pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid benzylamide;
31) 2- {5-Benzo[l,3]dioxol-5-yl-2-[l-(toluene-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}- pyridine;
32) 4-(4-Benzo[ 1 ,3]dioxol-5-yl-5-pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid 4-methyl-benzylamide;
33) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-methoxy-benzylamide;
34) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 2-chloro-benzylamide;
35) 4-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyτidin-2-yl-lH-imidazol-2-yl)-piperidine-l-sulfonyl]- benzoic acid;
36) 4-(4-Benzo [ 1 ,3] dioxol-5-yl-5 -pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid amide;
37) 4-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-sulfonyl]- benzonitrile;
38) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
39) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3 ,4-dicriloro-benzenesulfonyl)-piρeridin-4-yl]-3H- imidazol-4-yl} -pyridine;
40) {5-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-sulfonyl]- naphthalen- 1 -yl} -dimethyl-amine;
41) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(p3nidin-4-yl-methyl)-piperidin-4-yl)]-3H-imidazol-4- yl} -pyridine;
42) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
43) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-methoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine; 44) l-{4-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l- sulfonyl] -phenyl} -ethanone;
45) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-methyl-benzyl)-piperidin-4-yl]-3H-imiciazol-4-yl}- pyridine;
46) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3-fluoro-5-trifluoromethyl-benzyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
47) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-cyclohexylmethyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
48) 2-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-L -ylmethyl]- cyclopropanecarboxylic acid ethyl ester;
49) 2-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-l -ylmethyl]- pyrrolidine- 1-carboxylic acid tert-butyl ester;
50) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2,2-dimethyl-[l,3]dioxolan-4-ylmethyl)-piperidin-4- yl]-3H-imidazol-4-yl} -pyridine;
51) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-ethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
52) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(butane-l-sulfonyl)-ρiperidin-4-yl]-3H-imidazol-4-yl}- pyridine;
53) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-nitro-phenyhnethanesulfonyl)-piperidia-4-yl]-3H- imidazol-4-yl} -pyridine;
54) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-phenyl-ethenesulfonyl)-piperidin-4-yl]-3H-imidazol-
4-yl} -pyridine;
55) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(propane-l-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
56) 1 -[4-(4-Benzo[ 1 ,3]dioxol-5-yl-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidine- 1 - sulfonylmethyl]-7,7-dimethyl-bicyclo[2.2.1]heptan-2-one;
57) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
58) 2- { 5 -Benzo [1,3] dioxol-5 -yl-2- [ 1 -(3 , 5 -dichloro-phenylmethanesulfonyl)-piperidin-4-yl] -
3H-imidazol-4-yl} -pyridine;
59) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(4-fluoro-phenylmethanesulfonyl)-piperidixi-4-yl]-3H- imidazol-4-yl} -pyridine;
60) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,4-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl} -pyridine; 61) 2- {5-Benzo [ 1 ,3] dioxol-5-yl-2- £ 1 -(2-phenyl-ethanesulfonyl)-piperidin-4-yl] -3H-irni dazol- 4-yl} -pyridine;
62) 2-[5-Benzo[l ,3]dioxol-5-yl-2-( l-p-tolylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl] -pyridine;
63) 3-(4-Benzo[l,3]dioxol-5-yl-l-h.ydroxy-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l- carboxylic acid benzyl ester;
64) 3-(4-Benzo[ 1 ,3]dioxol-5-yl-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidine- 1 -carboxylic acid benzyl ester;
65) 4-[4-Benzo[l,3]dioxol-5-yl-l-h_ydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
66) 2-{5-Benzo[l,3]dioxol-5-yl-2-[ l-(pyridin-2-yl-methanesulfonyl)-piperidin-4-yl]-3H[- imidazol-4-yl} -pyridine;
67) 2-{5-Benzo[l,3]dioxol-5-yl-2-[ l-(2-naphthalen-l-yl-ethanesulfonyl)-piperidin-4-yl3-3H- imidazol-4-yl} -pyridine;
68) 2-[5-Benzo[l ,3]dioxol-5-yl-2-( 1 -phenylmethanesulfonyl-piperidin-3-yl)-3H-imidazol-4- yl] -pyridine;
69) 3-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
70) 2-{5-Benzo[l,3]dioxol-5-yl-2-[ l-(pyridin-4-yl-methanesulfonyl)-piperidin-4-yl]-3H[- imidazol-4-yl} -pyridine;
71) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-3-yl-methanesulfonyl)-piperidin-4-yl]-3HI- imidazol-4-yl} -pyridine;
72) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3-trifluoromethyl-phenylmethanesulfonyl)-pipericiin-4- yl]-3H-imidazol-4-yl} -pyridine;
73) 3-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl] - pyrrolidine- 1-carboxylic acid benzyl ester;
74) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[ 1 -(4-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4- yl]-3H-imidazol-4-yl} -pyridine;
75) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l -(3,5-bis-trifluoromethyl-phenylmethanesulfonyl)- piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
76) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(biρhenyl-4-sulfonyl)-ρiperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
77) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l -(3,5-difluoro-phenylmethanesulfonyl)-ρiperidin-4-yl]- 3H-imidazol-4-yl} -pyridine; 78) 2-{5-Benzo[l,3]dioxoϊ-'5-"yl-2-[l:fø imidazol-4-yl} -6-methyl-pyridine;
79) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-phenoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
80) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(biphenyl-4-ylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
81 ) 4-[5-Benzo[ 1 ,3]dioxol-5-yl- 1 -methyl-4-(6-methyl-pyridin-2-yl)- lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
82) 4-[4-Benzo[l,3]dioxol-5-yl-l-methyl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
83) {4-[4-Benzo[ 1 ,3]dioxol-5-yl- 1 -hydroxy-5-(6-methyl-pyridin-2-yl)- lH-imidazol-2-yl]- cyclohexylj-carbamic acid benzyl ester;
84) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[l -(3-phenoxy-phenylmethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl} -6-methyl-pyridine;
85) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-ethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
86) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(propane-l-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl } -6-methyl-pyridine;
87) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(butane-l-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}- 6-methyl-pyridine;
88) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-3-ylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
89) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-4-ylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
90) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
91) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4- yl] -3H-imidazol-4-yl} -6-methyl-pyridine;
92) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(thioρhene-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl } -6-methyl-pyridine;
93) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(butane-l-sulfonyl)-piperidin-3-yl]-3H-imidazol-4-yl}-
6-methyl-pyridine;
94) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-3-yl)-3H-imidazol-4- yl] -6-methyl-pyridine; 95)"2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(l-methyl-lH-imidazole-4-sulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
96) 2- { 5 -Benzo [1,3] dioxol-5 -yl-2- [ 1 -(5 -methyl-isoxazole-4-sulfonyl)-piperidin-4-yl] - 3H- imidazol-4-yl} -6-methyl-pyridine;
97) 4-[5-Benzo[l,3]dioxol-5-yl-l-liydroxy-4-(6-methyl-pyridm-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
98) Butane- 1 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl] -eye lohexyl} -amide;
99) N-{4- [4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexyrl}-C-pyridin-2-yl-methanesulfonamide;
100) Thiophene-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-cyclohexyl}-amide;
101) 1 -Methyl- lH-imidazole-4-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl- pyridin-2-yl)-lH-imidazol-2-yl]-cyclohexyl} -amide;
102) 4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imiciazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
103) 4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imiciazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
104) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-bromo-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
105) 2-{5-Benzo[l53]dioxol-5-yl-2-[l-(thiophene-3-sulfonyl)-piρeridin-4-yl]-3H-imidazol-4- yl} -6-metliyl-pyridine;
106) 2-{5-Berizo[l,3]dioxol-5-yl-2-[l-(5-methyl-2-trifluoromethyl-furan-3-sulfonyl)- piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
107) 4- [2- ( 1 -phenylmethanesulfonyl-piperidin-4-yl)-5 -(6-methyl-pyridin-2-yl) - 1 H-imidazol-
4-yl]-pyridin-2-yl-fluoride;
108) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-trifluoromethyl-ρyridin-2-yl)-lH-imidaz:ol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
109) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-bromo-pyridin-2-yl)-l-hydroxy-lH-imi(iazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
110) 2-[5--Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl] -6-bromo-pyridine;
111) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.-2.2]oct- 1 -yl} -methanol; 112) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
113) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-2H-imidazol-2-yl]-piperidiτie-l- sulfonic acid dimethylamide;
114) l-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin- 1 -yl} -3 -phenyl-propan- 1 -one;
115) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[l -(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
116) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carbonitrile;
117) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-ylamine;
118) N- {4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)- lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-C-phenyl-methanesulfonamide;
119) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct- 1 -yl} -methanesulfonaπxide;
120) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-niethyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-C-ρyridin-2-yl-methanesulfonamide;
121) 2-{5-Benzo[l,3]dioxol-5-yl-2-[4-(lH-tetrazol-5-yl)-bicyclo[2.2.2]oct-l-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
122) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetamide;
123) Thiophene-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl}-amide;
124) l-Methyl-lH-imidazole-4-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl- pyridin-2-yl)- 1 H-imidazol-2-yl] -bicyclo [2.2.2] oct- 1 -yl} -amide;
125) Thiophene-3 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl}-amide;
126) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-phenyl-ethenesulfonyl)-ρiperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
127) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
128) Methanesulfonic acid 4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]oct-l-ylmeth.yl ester; 129) {4-[4-Benzo[l,3]dioxol-5-yl-'5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetonitrile;
130) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyri(iin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetic acid;
131) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyτidin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-ylmethyl}-methanesulfonamide;
132) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(biphenyl-4-sταlfonyl)-piperidin-4-yl]-3H-imidazol-4- yl } -6-methyl-pyridine;
133) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-phenoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
134) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[l -(3,4-dichloro-"benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl}-6-methyl-pyridine;
135) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyτidin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-ylmethyl}-C-phenyl-methanesulfonamide; 136) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyxidin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2] oct- 1 -ylmethyl } -C-pyridin-2-yl-methaxiesulfonamide; 137) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid benzylamide;
138) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (pyridin-2-ylrnethyl)-amide; 139) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid 3-chloro-4-fliαoro-benzylamide; 140) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (furan-2-ylmethyl)-amide;
141) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfoo.yl-pyrrolidin-3-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
142) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(butane-l-sulfonyl)-pyrrolidin-3-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
143) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(l-methyl-lH-imidazole-4-sulfonyl)-pyrrolidin-3-yl]- 3H-imidazol-4-yl}-6-methyl-pyridine;
144) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-pyrrolidin-3-yl)-3H-imidazol- 4-yl] -6-methyl-pyridine;
145) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloro-benzenesulfonyl)-pyrrolidin-3-yl]-3H- imidazol-4-yl} -6-methyl-pyridine; 146) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(2-nitro-phenylmethanesulfonyl)-piperidm-4-yl] -3 H- imidazol-4-yl} -6-methyl-pyridine;
147) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-naphthalen-2-yl-ethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl}-6-methyl-pyridine;
148) l-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-pipericaine- 1 -sulfonylmethyl} -7,7-dimethyl-bicyclo[2.2. l]heptan-2-one;
149) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
150) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methylamide;
151) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid ethylamide;
152) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid butylamide;
153) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid isopropylamide;
154) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2]octane- 1 -carboxylic acid (3 -imidazol- 1 -yl-propyl)-amide;
155) 2-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-
1 -sulfonylmethyl} -phenylamine;
156) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (l-methyl-5-methylsulfanyl-lH-[l,2,4]triazol-3-yl)- axnide;
157) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid cyclohexylamide;
158) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct- 1 -yl} -pyrrolidin- 1 -yl-methanone;
159) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid dimethylamide;
160) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid diethylamide;
1 61) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid dipropylamide;
162) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (5,7-difluoro-benzothiazol-2-yl)-amide; 163) 4-[4-Benzo[l ,3] dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1-carboxylic acid benzothiazol-2-ylamide; 164) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1-carboxylic acid (lH-benzoimidazol-2-yl)-amide; 165) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1-carboxylic acid (2-hydroxy-l-methyl-2-phenyl-ethyl)-amide; 166) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1-carboxylic acid (pyridin-4-ylmethyl)-amide;
167) {4-[4-Benzo[l ,3 ]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin-l- yl}-(3-chloro-phenyl)-methanone;
168) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin-l- yl} -(4-fluoro-phenyl)-methanone;
169) {4-[4-Benzo[l ,3 ]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin-l- yl}-(4-methoxy-phenyl)-methanone;
170) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-cyclopropyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1-carboxylic acid;
171) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1-carboxylic acid methoxy-amide; 172) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1-carboxylic acid hydroxyamide;
173) {4-[4-Benzo[l ,3 ]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl}-carbamic acid benzyl ester;
174) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1-carboxylic acid hydrazide;
175) N-{4-[4-Benzo[l33]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-iniidazol-2-yl]- cyclohexylmethyl}-acetamide;
176) N-{4-[4-Benzo[l53]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmetliyl}-m.ethanesulfonamide;
177) N-{4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl}-C-phenyl-methanesulfonamide;
178) Butane- 1 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-cyclohexylmethyl} -amide;
179) Propane-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl] -cyclohexylmethyl } -amide; 180) N- {4-[4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-l H-imidazol-2-yl]- cyclohexylmethyl}-C-pyridin-2-yl-methanesulfonamide;
181) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl}-C-pyridin-4-yl-methanesulfonamide;
182) (4-Methoxy-benzyl)-{4-[5-(6-methyl-pyridin-2-yl)-2-(l-phenylmethanesulfonyl- piperidin-4-yl)-lH-imidazol-4-yl]-pyridin-2-yl}-amine;
183) 4-[5-(6-Methyl-pyridin-2-yl)-4-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
184) 4-[5-(6-Methyl-pyridin-2-yl)-4-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl- lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
185) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
186) 4-[4-(6-Methyl-ρyridin-2-yl)-5-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
187) 4-[4-(6-Methyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
188) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[l ,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl] -bicyclo [2.2.2] octane- 1 -carboxylic acid;
189) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-2,2,2-trifluoro-acetamide;
190) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
191) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l -carboxylic acid amide;
192) 4-[4-(6-Cyclopropyl-ρyridm-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridm-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
193) N- {4-[5-Benzo[l ,3]dioxol-5-yl-4-(6-meth.yl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-sulfamide;
194) Sulfamic acid 4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl ester;
195) {4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl- 1 H-imidazol-2-yl]-cyclohexyl} - carbamic acid benzyl ester;
196) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carbonyl}-methanesulfonamide; 197) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carbonyl}-benzenesulfonamide;
198) 4- [5-(3 -Methyl-4-oxo-3 ,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)- 1 H- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
199) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid;
200) N- {4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl} - acetamide;
201) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-"bicyclo[2.2.2]octane-
1-carboxylic acid methyl ester;
202) 4-[4-(6-Methyl-pyridm-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-"bicyclo[2.2.2]octane-
1-carboxylic acid;
203) 4-[4-(6-Methyl-pyridin-2-yl)-5-qumoxalin-6-yl-lH-imidazol-2-yl]-t)icyclo[2.2.2]octane-
1 -carboxylic acid hydroxyamide;
204) 4-[4-(6-Methyl-pyridm-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-lDicyclo[2.2.2]octane-
1-carboxylic acid amide;
205) N- {4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl} - methanesulfonamide;
206) 2,2,2-Trifluoro-N- {4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl- 1 H-imidazol-2-yl]- cyclohexyl} -acetamide;
207) 4-[4-(5-Fluoro-6-methyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol- 2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
208) {4-[2- [ 1 -(Butane- 1 -sulfonyl)-piperidin-4-yl] -5-(6-methyl-pyridin-2- yl)- 1 H-imidazol-4- yl]-pyridin-2-yl}-(4-methoxy-benzyl)-amine;
209) 4-[2-[ 1 -(Butane- 1 -sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)- lH-imidazol-4- yl]-pyridin-2-ylamine;
210) 2-[5-Benzo[ 1 ,3]dioxol-5-yl-2-(l -phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl] -6-ethyl-pyridine;
211) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
212) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide; 213) N-{4-[5-(6-Methyl-pyridin-2-yl)-4-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanesulfonamide; 2l4) N-{4-[5-(6-Methyl-pyridin-2-yl)-4-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetamide.
215) 4-[2-(6-Methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyridin-3-yl]-pyrimidin-2-ylamine;
216) 4-(2-pyridin-2-yl-pyrazolo[l,5-a]pyridin-3-yl)-pyrimidin-2-ylamine; 217) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyridin-3-yl]-pyrimidin-2-ylamine;
218) 2-(6-methyl-pyridin-2-yl)-3-(2-metliylsulfanyl-pyrimidin-4-yl)-pyrazolo[l,5-a]pyridine;
219) 4-[2-(6-chloro-p)τidm-2-yl)-pyrazolo[l,5-c]pyrimidm-3-yl]-pyrimidin-2-ylamine;
220) 2-(6-methyl-pyridin-2-yl)-3-(2-morpholin-4-yl-pyrimidin-4-yl)-pyrazolo[ 1 ,5- c]pyrimidine;
221) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyrazin-3-yl]-pyrimidin-2-ylamine;
222) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyrimidin-3-yl]-pyrimidin-2-ylamine;
223) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-c]pyrimidin-3-yl]-pyrimidin-2-ylamine;
224) (2-Methoxy-ethyl)-{4-[2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
225) (3-{4-[2-(6-Methyl-pyridin-2-yl)-iinidazo[l52-a]pyridin-3-yl]-pyrimidin-2-ylamino}- propyl)-carbamic acid tert-butyl ester;
226) (3-Imidazol-l-yl-propyl)-{4-[2-(6-niethyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
227) (4-Methoxy-benzyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
228) [2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridin-
6-yl]-methanol;
229) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridine;
230) (4-{4-[2-(6-Methyl-pyridin-2-yl)-irriidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylammo}- butyl)-carbamic acid tert-butyl ester;
231) (4-Amino-benzyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
232) (5-{4-[2-(6-Methyl-pyridin-2-yl)-im.idazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- pentyl)-carbamic acid tert-butyl ester;
233) [3-(2-Amino-pyrimidin-4-yl)-2-(6-rn.ethyl-pyridin-2-yl)-imidazo[l,2-a]pyridm-6-yl3- methanol;
234) [3-(2-amino-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[ 1 ,2-a]pyridin-7-yl] - methanol; 235) [3-(2-Amino-pyrimidm-4'-yl):'6-methyl-2-(6-methyl-pyridin-2-yl)-iniidazo[l,2- a]pyridin-8-yl]-(2-morpholin-4-yl-ethyl)-amine;
236) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(2-pyridin-2-yl-ethyl)-amine;
237) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(2-pyridin-3-yl-ethyl)-amine;
238) [3-(2-methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridin-6-yl]-methanol;
239) [3 -(2- Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2- a]pyridin-8-yl]-(2-pyridin-4-yl-ethyl)-amine;
240) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridin-8-yl]-(3-morpholin-4-yl-propyl)-amine;
241 ) [3 -(4-Methyl-piperazin- 1 -yl)-propyl] - {4-[2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2- a]pyridin-3-yl]-pyrimidin-2-yl}-amine;
244) [3-(4-Methyl-piperidin-l-yl)-propyl]-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-3 -yl] -pyrimidin-2-yl} -amine;
245) [4-(2-Pyridin-2-yl-imidazo[l,2-a]pyridin-3-yl)-pyrimidin-2-yl]-pyridin-3-ylmethyl- airline;
246) {4-[2-(6-Methyl-pyridm-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-((R)-l- phenyl-ethyl)-amine;
247) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-((S)-l- phenyl-ethyl)-amine;
248) {4-[2-(6-Methyl-pyridm-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(lH- tetrazol-5-yl)-amine;
249) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2H- pyrazol-3 -yl)-amine;
250) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2- morpholin-4-yl-ethyl)-amine;
251) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2-pyridm- 2-yl-ethyl)-amine;
252) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-yl} -(2-pyridin- 3 -yl-ethyl)-amine;
253) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2-pyridin- 4-yl-ethyl)-amine; 254) {4-L2-(6-Melhyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl} -(3- moφholin-4 -yl-propyl)-amine;
255) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(3- piperidin- 1 -yl -propylamine;
256) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- [ 1 ,3 ,4]thiadiazol-2-yl-amine;
257) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,Z-a]pyridine;
258) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridine- 6-carboxylic acid methyl ester;
259) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidm-4-yl)-imidazo[l,2-a]pyridine- 7-carboxylic acid ethyl ester;
260) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2- aJpyrimidin-V-ylamine;
261) {7,7-Dύmethyl-8-[5-(4-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridia-3-yl]- pyrimidin-2-ylamino}-butylcarbamoyl)-pentyl]-2-oxo-4-trifluoromethyl-7,8-dihy"dro-2H-l- oxa-8-aza-anthracen-5-yl} -methanesulfonic acid;
262) 2-(2,7-Difluoro-6-hydroxy-3-oxo-9,9a-dihydro-3H-xanthen-9-yl)-3,5,6-trifluoro-4-[(4- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridm-3-yl]-pyrimidin-2-ylamino} - butylcarbamoyl)-methylsulfanyl]-benzoic acid;
263) -(6-Methyl-pyridm-2-yl)-3-(2-morpholin-4-yl-pyrimidin-4-yl)-imidazo[ 1 ,2-a]pyridine;
264) 2-(6-Methyl-pyridin-2-yl)-3-(2-piperidin-l-yl-pyrimidin-4-yl)-imidazo[l,2-a]pyridine;
265) 2-(6-Methyl-pyridin-2-yl)-3-(2-pyrrolidin- 1 -yl-pyrimidin-4-yl)-irnidazo[ 1 ,2-a]pyridine; 266) 2-(6-Methyl-pyridin-2-yl)-3-[2-(lH-tetrazol-5-yl)-pyrimidin-4-yl]-imidazo[l,2- ajpyridine;
267) 2-(6-Methyl-pyridin-2-yl)-3-pyrimidin-4-yl-imidazo[ 1 ,2-a]pyridine;
268) 2-(6-Methyl-pyridin-2-yl)-3-pyrimidin-4-yl-imidazo[ 1 ,2-a]pyrimidin-7-ylairiine;
269) 3-(2-Arriino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridixi-8- ylamine;
270) 3-(2-Arriino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridirie-6- carbonitrile;
271) 3-(2-Arαino-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridirαe-6- carboxylic acid;
272) 3-(2-Arnino-pyrimidin-4-yl)-2-(6-methyl-ρyridin-2-yl)-imidazo[l,2-a]pyridirie-6- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide; Tl 5) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide;
274) 3-(2-Amino-pyrimidin-4-yl)-2 -(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid (2-dimethylamino-ethyl)-amide;
275) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid (2-methoxy-ethyl)-ainide;
276) 3-(2-7\mino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid (2-thiophen-2-yl-eth.yl)-atnide;
277) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid [3-(4-methyl-piperazin-l-yl)-propyl]-amide;
278) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid amide;
279) 3-(2-Amino-ρyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid cyclopropylamide;
280) 3-(2-Amino-pyrimidin-4-yl)-2-(6-metriyl-pyridin-2-yl)-irnidazo[l,2-a]pyridme-6- carboxylic acid ethylamide;
281) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid hydroxyamide;
282) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid methoxy-amide;
283) 3-(2-Amino-pyrimidin-4-yl)-2-(6-rnethyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid methyl ester;
284) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid;
285) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-7- carboxylic acid ([l,4]dioxan-2-ylmetliyl)-amide;
286) 3-(2-Amino-pyrimidin-4-yl)-2-C6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (2-amino-ethyl)-amid.e;
287) 3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (2-dimethylamino-ettαyl)-amide;
288) 3-(2-Amino-ρyrimidin-4-yl)-2-(^6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridme-7- carboxylic acid (2-hydroxy-ethyl)-amide;
289) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (2-oxo-2-pyridin-3-yl-ethyl)-amide; 290) 3-(2-Aniino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-irnidazo[l,2-a]pyridine-7- carboxylic acid (2-thiophen-2-yl-ethyl)-amide;
291) 3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-inαidazo[l,2-a]pyridine-7- carboxylic acid (piperidin-3-ylmethyl)-amide;
292) 3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-in^iidazo[l,2-a]pyridine-7- carboxylic acid 2,2-dimethylhydrazide;
293) 3-(2-Amino-pyrimidin-4-yl)-2-(6-rnethyl-pyridin-2-yl)-intiidazo[l,2-a]pyridine-7- carboxylic acid amide;
294) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-iirιidazo[l,2-a]pyridine-7- carboxylic acid cyclopropylamide;
295) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-iinidazo[ 1 ,2-a]pyridine-7- carboxylic acid ethyl ester;
296) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-ρyridin-2-yl)-iπxidazo[ 1 ,2-a]pyridine-7- carboxylic acid ethylamide;
297) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-inxidazo[l,2-a]pyridine-7- carboxylic acid hydroxyamide;
298) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-inxidazo[l,2-a]pyridine-7- carboxylic acid methoxy-amide;
299) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-iniidazo[ 1 ,2-a]pyrimidin-7- ylamine;
300) 3-(2-Azetidin-l-yl-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-irriidazo[l,2-a]pyridine;
301) 3-(2-Methanesulfonyl-pyrirnidin-4-yl)-2-(6-methyl-pyridiri-2-yl)-imidazo[l,2-a] pyridine-7-carboxylic acid ethyl ester;
302) 3 -(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridiri-2-yl)-imidazo [ 1 ,2- a]pyridine-6-carboxylic acid methyl ester;
303) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-7-methyl-2-(6-methLyl-pyridm-2-yl)-imidazo[ 1 ,2- a] pyridine;
304) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-8-methyl-2-(6-methLyl-pyridin-2-yl)-imidazo[l,2- a] pyridine;
305) 3,3-Dimethyl-N-[2-(6-methyl-pyridm-2-yl)-3-(2-methylsulfanyl-ρyrimidin-4-yl)- imidazo[ 1 ,2-a]pyrimidin-7-yl]-butyramide;
306) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridiπL-2-yl)-imidazo[l,2- a]pyridine-6-carbonitrile;
307) 3-(2-Methylsulfanyl-pyrimidin-4-yl)-2-pyridin-2-yl-imidazo[l,2-a]pyridine; 308) 3,6-Dichloro-N-(4-{4-[2-(6-methyl-ρyridin-2-yl)-imidazo[l,2-a]ρyridin-3-yl]- pyrimidin-2-ylamino}-butyl)-2-(2,4,5,7-Tetrachloro-6-hydroxy-3-oxo-9,9a-dihydro-3 H- xanthen-9-yl)-terephthalamic acid;
309) 3-[2-(2-Methyl-aziridin-l-yl)-pyrimidin-4-yl]-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyridine;
310) 3-[2-(4-Methyl-piperazin-l-yl)-pyrimidin-4-yl]-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a] pyridine;
311) 3-{[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridiiie-6- carbonyl] -amino} -propionic acid methyl ester;
312) 3-{[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridine-7- carbonyl] -amino} -propionic acid methyl ester;
313) 3-{4- [2-(6-Methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridin-3 -yl]-pyrimidin-2-ylamino } - phenol;
314) 4-(2- {4- [2-(6-Methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridin-3 -yl] -pyrimidin-2-ylarnino} - ethyl)-benzenesulfonamide;
315) 4-(2-Pyridin-2-yl-imidazo[ 1 ,2-a]pyridin-3-yl)-pyrimidm-2-ylamine;
316) 4-[2-(6-Chloro-pyridin-2-yl)-imidazo[l ,2-a]pyridm-3-yl]-pyrimidin-2-ylamine;
317) 4- [2-(6-Methyl-pyridin-2-yl)-7-trifluoromethyl-imidazo [ 1 ,2-a]pyridin-3 -yl]-pyrirnidin- 2-yl-amine;
318) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamine;
319) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidine-2-carbonitrile;
320) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidine-2-carboxylic acid amide;
321) 4-[6-Bromo-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
322) 4-[6-Chloro-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
323) 4-[6-Fluoro-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
324) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-morpholin-4-yl-ethylamino)-imidazo [ 1 ,2-a] pyridin-3-yl]-pyrimidin-2-ol;
325) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-2-yl-ethylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidin-2-ol; 326) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-3-yl-ethylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidin-2-ol; 327) 4-[6-Methyi-2-(6-methyl-ρyridin-2-yl)-8-(2-pyridin-4-yl-ethylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidiri-2-ol;
328) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-morpholin-4-yl-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ol;
329) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-moφholin-4-yl-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2 -ylamine;
330) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
331) 4-[7-Aminomethyl-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2- yl-amine;
332) 4-[7-Methyl-2-(6-rnethyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
333) 4-[8-Benzyloxy-2-(6-rnethyl-pyridin-2-yl)-imidazo[l,2-a]pyridm-3-yl]-pyriniidin-2-ol; 334) 4-[8-Benzyloxy-Z-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyriniidin-2-yl- amine;
335) 4-[8-Bromo-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin- 2-ol;
336) 4-[8-Methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
337) 6-Chloro-3-(2-methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-iniidazo[l,2- a] pyridine;
338) 5-Dimethylamino -naphthalene- 1 -sulfonic acid (4-{4-[2-(6-methyl-pyridin-2-yl)- imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} -butyl)-amide;
339) 6-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-N-(4-{4-[2-(6-methyl-pyridin-2-yl)- imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylammo}-butyl)-isophthalamic acid; 340) 6-Amino-9-[2-carboxy-5-(4-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ylamino}-TDutylcarbamoyl)-plienyl]-xanthen-3-ylidene-aminonmm;
341) 6-Bromo-2-(6-methyl-pyridin-2-yl)-3 -(2-methylsulfanyl-pyrimidin-4-yl)-imidazo [ 1 ,2-a] pyridine;
342) 6-Fluoro-2-(6-methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a] pyridine;
343) 7-Amino-4-methyl-3-[(4-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ylamino}-"butylcarbamoyl)-methyl]-2-oxo-2H-chromene-6-sulfonic acid;
344) Cyclobutyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-yl} - amine; 345) Cyclopentyl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridm-3-yl]-pyrimi(lin-2- yl} -amine;
346) Cyclopropyl- {4-[2-(6-methyl-pyridin-2 -yl)-imidazo[ 1 ,2-a]pyridin-3 -yl] -pyrimiclin-2- yl} -amine;
347) Cyclopropyl-methyl- {4-[2-(6-methyl-p;yridm-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
348) Dimethyl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- amine;
349) Isopropyl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- amine;
350) Methyl- {4- [2-(6-methyl-pyridin-2-yl)-irnidazo [ 1 ,2-a]pyridin-3 -yl] -pyrimidin-2- y\}- amine;
350a) N-(2- {4-[2-(6-Methyl-pyridin-2-yl)-inαidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2- ylamino } -ethyl)-acetamide;
351) N-(4- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- butyl)-acetamide;
352) N,N-Dimethyl-N'-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyximidin- 2-yl} -ethane- 1 ,2-diamine;
353) N-[2-(6-Methyl-pyridin-2-yl)-3-(2-meth.ylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a] pyrimidin-7-yl] -3 -pyridin-3 -yl-propionamide ;
354) N-[2-(6-Methyl-pyridin-2-yl)-3-(2-methiylsulfanyl-pyriinidm-4-yl)-imidazo[l ,2- a] pyrimidin-7-yl] -nicotinamide;
355) N-[2-(6-Methyl-pyridin-2-yl)-3-(2-methLylsulfanyl-pyrimidin-4-yl)-imidazo[1.2-a] pyrimidin-7-yl]-propionamide;
356) N-[3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carbonyl] -methanesulfonamide;
357) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carbonyl] -methanesulfonamide;
358) N-[3-(2-Amino-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyritnidin-7- yl]-2-(3-methoxy-phenyl)-acetamide;
359) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyrimidin-7- yl] -3 ,3 -dimethyl-butyramide;
360) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidin-7- yl] -3 -pyridin-3-yl-propionamide; 3ό 1 ) JN-L3-(2-Amino-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]p;yrimidin-7- yl]-acetamide;
362) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]p3αimidin-7- yl]-nicotinamide;
363) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyrimidin-7-yl] -2-(3 -methoxy-phenyl)-acetamide ;
364) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidaz;o[ 1 ,2-a] pyrimidin-7-yl]-3,3-dimethyl-butyramide;
365) N-[3-(2-Methanesulfonyl-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidaz;o[l,2-a] pyrimidin-7-yl]-3-pyridin-3-yl-propionamide;
366) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidaz:o[l,2-a] pyrimidin-7-yl]-nicotinamide;
367) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidaz;o[l,2-a] pyrimidin-7-yl] -propionamide;
368) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidin-7- yl] -propionamide;
369) N-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridm-3-yl]-pyrimidin-2-y-l}- acetamide;
370) Nl-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-butane- 1,4-diamine;
37I) Nl- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-^l} - propane- 1 ,3 -diamine;
372) N-(4-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- butyl)-(BODIPY FL) amide; and
373) N-(4-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- butyl)-(Texas Red-X) amide
374) N-[3-(2-amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyrimidin-7- yl] -acetamide;
375) N- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-yl } - acetamide,
376) 3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propylamine, 377) N-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propyl]-acetamide, 378) N-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propyl]-methanesulfonanαide, 379) dimethyl-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propyl]-amine3
380) 4-{3-pyridin-2-yl-l-[2-(lH-tetrazol-5-yl)-ethyl]-lH-pyrazol-4-yl}-quinoline- 381) 4-[3-pyriSm-2-yϊ-ϊ-(3-pyifolϊ(din- 1 -yl-propyl)- 1 H-pyrazol-4-yl] -quinoline,
382) 5-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-pyridin-2-ylamine, 383) 2,4-dimethoxy-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyrimidine,
384) 3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propionic acid,
385) 5-(3 -pyridin-2-yl- 1 H-ρyrazol-4-yl)- 1 H-indole, 386) 2-[4-(2,3-dihydro-benzo[l,4]dioxin-6-yl)-lH-pyrazol-3-yl]-pyridine, 387) N-hydroxy-3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propionamide, 388) 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-ethylamine, 389) N-[2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-ethyl]-methanesulfonamide, 390) 2-methyl-4-methylsulfanyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyrimidine, 391) 2-(4-benzo [1,3] dioxol-5-yl- 1 H-pyrazol-3-yl)-pyridine, 392) 2-[4-(2,3-dihydro-benzofuran-5-yl)-lH-pyrazol-3-yl]-pyridine,
393) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[d]isoxazole,
394) 3-[4-benzo [1,3] dioxol-5-yl-3 -(6-methyl-pyridin-2-yl)-pyrazol- 1 -yl] -propionitril e, 395) N-{3-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-propyl> - methanesulfonamide, 396) 2-[4-(2,3-dihydro-benzo[l,4]dioxin-6-yl)-lH-pyrazol-3-yl]-6-methyl-pyridine,
397) [4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-acetonitrile,
398) N- {2-[4-benzo[ 1 ,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-ρyrazol- 1 -yl]-ethyl} - methanesulfonamide, 399) 4-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-2-methylsulfanyl-pyrimidine,
400) 4-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-2H-phthalazin- 1 -one,
401) l-[5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-2,3-dihydro-indol-l-yl]-ethanone, 402) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]pyridine,
403) 3 -methyl-6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-3H-quinazolin-4-one,
404) 6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-4H-benzo [1,4] oxazin-3 -one,
405) 6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-quinoxaline,
406) 3-(4-nitro-benzyl)-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one, 407) 5-methyl-6-(3-pyridin-2-yl-lH[-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]pyridine,
408) 4-methyl-7-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-3 ,4-dihydro- lH-benzo [e] [ 1 ,4]diazepine- 2,5-dione,
409) 2,3-dimethyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
410) 6-[3-(6-methyl-pyridin-2-yl)- 1 H-pyrazol-4-yl]-[l ,2,4]triazolo[l ,5-a]pyridine, 41 Oa) 1 -methoxy-4-(3-pyridin-2-yl- lH-pyrazol-4-yl)-isoquinoline,
411) 2-methyl-6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)- [ 1 ,2,4]triazolo[ 1 ,5-a]pyridine, 41 Ia) "4-(3 -pyrϊdϊh-2-yl- 1 H-pyrazόl-4-yl)-2H-isoquinolin- 1 -one,
412) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-trifluoromethyl-pyridine, 412a) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-vinyl-pyridine,
413) 2-(4-benzo[l ,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-propenyl-pyridine,
414) 2-(4-benzo [ 1 ,3 ]dioxol-5 -yl- 1 H-pyrazol-3-yl)-6-ethyl-ρyridine,
415) 2-(4-benzo[l ,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-propyl-pyridine,
416) 2-(4-benzo[ 1 ,3]dioxol-5-yl- 1 H-pyrazol-3-yl)-6-cyclopropyl-pyridine,
417) l-[6-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-pyridin-2-yl]-ethanol,
418) 4-methoxy-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline,
419) 6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-quinoline,
420) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolin-4-ylamine, 421) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
422) 7-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyrido[l,2-a]ρyrimidin-4-one,
423) 6-[3-(6-cyclopropyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[ 1 ,2,4]triazolo[ 1 ,5~a]pyridine, 424) 3-methyl-6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3H-quinazolin-4-one, 425) 4-(2-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethoxy}- ethoxy)-bicyclo[2.2.2]octane-l-carboxylic acid,
426) 4-(2-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethoxy}- ethoxy)-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester, 427) 4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-ρyrazol-l-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester, 428) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-isopropyl-pyridine,
429) 2-(4-benzo[l,3]dioxol-5-yl-5-trifluoromethyl-lH-pyrazol-3-yl)-6-bromo-pyridine,
430) 6-[3-(5-fluoro-6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l ,2,4]triazolo[l ,5-a]pyridine, 431) 6-[3-(6-trifluoromethyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine,
432) 6- [3 -(6-methyl-pyridin-2-yl)- 1 H-pyrazol-4-yl] -quinoxaline,
432a) 6-[3-(6-cyclopropyl-ρyridin-2-yl)-lH-pyrazol-4-yl]-3-methyl-3H-quinazolin-4-one,
433) 6-(3-pyridin-2-yl- 1 H-pyrazol-4-yl)- [ 1 ,2,4]triazolo[ 1 ,5-b]pyridazine, 433a) 6- [3 -(6-methyl-pyridin-2-yl)- 1 H-pyrazol-4-yl] -quinoline,
434) 6-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-3-fluoro-2-methyl-pyridine,
435) 7-methoxy-3 -methyl-6-(3-pyridin-2-yl- 1 H-pyrazol-4-yl)-3H-quinazolin-4-one,
436) (4-morpholin-4-yl-phenyl)-[6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolin-4-yl]-amine,
437) 4-isopropoxy-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline,
438) 6-(3-Pyridin-2-yl-lH-pyrazol-4-yl)-quinolin-4-ylamine, 439") {4-[Vbenzotϊ73]'3ibxol3-yl-5-(S-meiJiyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohe carbaniic acid benzyl ester,
440) 4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohexylamine, 441 ) N- {4-[4-benzo[ 1 ,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol- 1 -yl]-cyclohexyl} - methanesulfbnamide, 442) 6-[3-(5-fluoro-6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-quinoxaline,
443) 7-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridine,
444) 1 -tert-butyl-3 - [ 6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-qumazolin-4-yl] -urea,
445) 5-(3 -pyridin-2-yl-lH-pyrazol-4-yl)-benzo[l,2,5]thiadiazole,
446) 5-(3 -pyridin-2-yl-lH-pyrazol-4-yl)-benzo[l,2,5]oxadiazole,
447) 5-(3 -Pyridin-2-yl- lH-pyrazol-4-yl)-benzooxazole, 448) 4-rαorpholin-4-yl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline, 449) 6-[3-(6-trifluoromethyl-pyridin-2-yl)-lH-pyrazol-4-yl]-qumoxaline, 450) 4-(4-methoxy-phenyl)-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline,
451) 5-[3 -(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-benzo[l ,2,5]thiadiazole,
452) 6-(3 -pyridin-2-yl- lH-pyrazol-4-yl)-benzothiazole, 453) 3-(3-methoxy-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
454) 5-methyl-thiophene-2-carboxylic acid [6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolin-4- yl] -amide,
455) 5-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3-phenyl-benzo[c]isoxazole,
456) 3-(4~methoxy-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
457) 3-(4-chloro-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
458) 3-(4-ethyl-phenyl)-5-(3-ρyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
459) (4-methoxy-phenyl)-[6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-qumazolin-4-yl]-methanone,
460) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3-thiophen-3-yl-benzo[c]isoxazole,
461) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid,
462) 5-(3 -Pyridin-2-yl- lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid methylamide,
463) 5 -(3 -pyridin-2-yl- lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid dimethylamide,
464) 5 -(3 -pyridin-2-yl- lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid (2,2-dimethyl- propyl)-amide,
465) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid pheriylamide, 466) morpholin-4-yl-[5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazol-3-yl]-rnethanone,
467) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid benzylamide,
468) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid cyclopentylamide; 469) 4-f4-b'enzb['ϊ,3']di6xol-5-yl-5-(2-methylsulfanyl-pyrimidin-4-yl)-lH-imidazol^ benzamide;
470) 4-[4-benzo[l,3]dioxol-5-yl-5-(2-methylsulfanyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- benzonitrile;
471) 4-[5-(2-methanesulfonyl-ρyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl] - bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
472) 4-[5-(2-methoxy-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
473) 4-[5-(2-hydroxy-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
474) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
475) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)- 1 H-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid;
476) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
477) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
478) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methoxy-amide;
479) 4-[5-(2-amino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid;
480) {4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]oct-l-yl}-carbamic acid benzyl ester;
481) N- {4-[5-(2-cyclopropylarnino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol- 2-yl]-bicyclo[2.2.2]oct-l-yl}-acetamide;
482) N-{4-[5-(2-cyclopropylarnino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-irnidazol— 2-yl]-bicyclo[2.2.2]oct- 1 -yl} -methanesulfonamide;
483) N- {4-[5-(2-cyclopropylarnino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)- lH-imidazol- 2-yl]-bicyclo [2.2.2]oct- 1 -yl} -2 ,2,2-trifluoro-acetamide;
484) 4-[5-quinoxalin-6-yl-4-(2 -trifluoromethyl-pyrimidin-4-yl)- 1 H-imidazol-2-yl] - bicyclo[2.2.2]octan-l-ol;
485) 4-[4-(2-cyclopropyl-pyrirnidrn-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
486) 6-[2-tert-butyl-5-(2-cyclopropyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline; 487) S-[5-(2-B'ycl6propyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline;
488) {4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanol;
489) 6-[5-(2-trifluoromethyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline;
490) 6-[2-tert-butyl-5-(2-trifluoromethyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline;
491) 4-[5-quinoxalin-6-yl-4-(2-trifluoromethyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
492) 4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
493) 6-[5-(2-cyclopropyl-pyrimidin-4-yl)-2-(l-methanesulfonyl-piperidin-4-yl)-3H-imidazol- 4-yl] -quinoxaline;
494) 4-[5-(2-methyl-pyrimidin-4-yl)-4-[l,2,4]triazolo[4,3-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
495) 4-[4-(2-methyl-pyrimidin-4-yl)-5-[l,2,4]Mazolo[l,5-a]pyridine-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
496) 4-[4-(2-methyl-pyrimidin-4-yl)-5-[l,2,4]1riazolo[l,5-a]pyridine-6-yl-lH-imidazol-2-yl]- bicyclo [2.2.2] octane- 1 -carboxylic acid;
497) 4-[4-(2-methyl-pyrimidin-4-yl)-5-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridine-6-yl- 1 H-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
498) 4-[4-(2-methyl-pyrimidin-4-yl)-5-qumoxalin-6-yl-lH-imidazol-2-yl]-cyclohexanol, 499) 4-[4-(2-methyl-pyrimidin-4-yl)-5-quinoxalirα-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol,
500) 4-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-2-methyl-pyrimidine,
500a) 6-[3-(2-metb.yl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine,
501) 6- [3-(2-trifluoromethyl-pyrimidin-4-yl)- lH-pyrazol-4-yl] -[ 1 ,2,4]triazolo [ 1 ,5-a]pyridine, 502) 6- [3 -(2-methyl-pyrimidin-4-yl)- 1 H-pyrazol- 4-yl] -quinoxaline,
502a) 6-[3-(2-trifluoromethyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-quinoxaline,
503) 6-[3-(2-cyclopropyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-quinoxaline,
504) 4-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-2-trifluorometliyl-pyrimidine,
505) 7- [3 -(2-trifluoromethyl-pyrimidin-4-yl)- 1 H-pyrazol-4-yl] -[1 ,2,4]triazolo [ 1 ,5 -a]pyridine, or
506) 6-[3-(2-Trifluoromethyl-pyrimidin-4-yl)-lH-pyi-azol-4-yl]-quinoline.
9. The method of claim 1 , wherein the inhibitor is administered locally.
10. The method of claim 1, wherein the inhibitor is administered via an implantable device.
11. "The method of "claim l"d',"wh'efeiή""the device is a delivery pump.
12. The method of claim 10, wherein the device is a stent.
13. A method of inhibiting vascular remodeling by administering to a subject in need thereof an inhibitor to TGFβ type I receptor orAlk4 .
14. The method of claim 13, wherein the inhibitor has the structure shown in formula I:
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein
R1"1 is aryl, heteroaryl, aralkyl, or heteroaralkyl; each R!"a is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkyl sulfanyl, alkylsulfmyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
X1-1 is cycloalkyl or heterocycloalkyl;
Y1-1 is a bond, -C(O)-, -C(O)-O-, -O-C(O)-, -S(O)P-O-, -O-S(O)P-, -C(O)-N(Rb)-, -N(Rb)-C(O)-, -O-C(O)-N(Rb)-, -N(Rb)-C(O)-O-, -O-S(O)p-N(Rb)-, -N(Rb)- SCO)P-O-, -N(Rb)-C(O)-N(Rc)-, -N(Rb)-S(O)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb>C(O)-, -C(O)-N(Rb)-S(O)p-N(Rc)-, -C(O)-O-S(O)p-N(Rb)-, -N(Rb)-S(O)p-N(Rc)-C(O)-, -N(Rb)-S(O)p-O-C(O)-, -S(O)p-N(Rb)-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)P-, -O-, -S-, or -(C(Rb)(Rc))q-, wherein each of Rb and Rc is independently hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; p is 1 or 2; and q is 1-4;
R1"2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl; each of A*1"1 "and A'fΩj independently, is O, S, N, or NRb, provided that at least oxie of A 1"1 and A '"2 Is NT; and m is 0, 1, 2, or 3, and when m >2, two adjacent R'"a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety.
15. The method of claim 13, wherein the inhibitor has the structure shown in formula II:
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein each of Xn
-1, Xn
-2, Xn
-3, and Xn
-4 is independently CR
X or N, provided that no more than two OfXn
-1, IXn
-2, Xπ-3
5 and X
11-4 can be N simultaneously; each Of Yn
-1 and Yn
-2 is independently CR
y or N, provided that at least one Of Yx
1-1 and Y
11-2 must be ISf; each R
11"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfπryl., alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsiαlfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; each R
11"2 is independently alkyl, alkenyl, alkynyl, acyl, halo, hydroxy, -NH
2, - NΗ(alkyl), -N(alkyl)
2, -NH(cycloalkyl), -N(alkyl)(cycloa]kyl), -NHCheterocycloalkyl), - NH(heteroaryl),
-NH-alkyl-heterocycloalkyl, -NH-alkyl-heteroaryl, -NH(aralkyl), cycloalkyl, (cycloalkyl)alkyl, aryl, aralkyl, aroyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heteroaryl, heteroaralkyl, heteroaroyl, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkoxy, cycloalkyloxy, cycloalkyl-alkoxy, aryloxy, arylalkoxy, heterocycloalkyloxy, (heterocycloalkyl)aUcoxy, heteroaryloxy, heteroarylalkoxy, alkylsulfanyl, cycloalkylsulf anyl, (cycloalkyl)alkylsulfanyl, arylsulfanyl, aralkylsulfanyl, heterocycloalkylsulfanyl, (heferocycϊoaϊky^allc'yrsul'Faήyl1, h'eteroarylsulfanyl, heteroarylalkylsulfanyl, alkylsulfmyl, alkylsulfonyl, aminocarbonyl, arninosulfonyl, alkylcarbonylamino, cycloalkylcarbonylamino, (cycloalkytyalkylcarbonylarnino., arylcarbonylamino, aralkylcarbonylamino, (heterocycloalky^carbonylamino, (heterocycloalkyl)alkylcarbonylamino, heteroarylcarbonylamino, hetero aralkylcarbonylamino, alkoxycarbonylaminoalkylamino, (heteroaryl)arylcarbonylaminoalkylamino, heteroaralkylcarbonylaminoalkylamino, (heteroaryl)arylsulfonylaminoalk:ylcarbonylaminoalkylamino, arylsulfonylaminoalkylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, or carbamoyl; m is 0, 1, 2, 3, or 4, and when m >2, two adjacent R1 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; n is 0, 1, 2, or 3, and when n >2, two adjacent R2 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; and each of Rx and Ry is independently hydrogen, alkyl, alkenyl, allcynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, cycloalkylcarbonyl, (cyclo alkyl) alkylcarbonyl, aroyl, aralkylcarbonyl, heterocycloalkylcarbonyl, (heterocycloalkyl)acyl, heteroaroyl, (heteroaryl)acyl, aminocarbonyl, alkylcarbonylamino, (amino)aminocarbonyl, alkylsulfonylaminocarbonyl, alkylsulfonylamino, cycloalkylcarbonylamino, cycloalkylsulfonylamino, (cycloa-lkyl)alkylcarbonylamino, (cycloalkyT) alkylsulfonylamino, arylcarbonylamino, arylsulfonylamino, aralkylcarbonylamino, aralkylsulfonylamino, (heterocycloalkytycarbonylamino, (heterocycloalkyl)sulfonylamino, (heterocycloalky^alkylcarbonylamino, (heterocycloalky^alkylsulfonylamino, heteroarylcarbonylamino, hetero arylsulfonylamino, heteroaralkylcarbonylamino, heteroaralkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, (cycloalkyl)alkyl, (cycloalkyl)alkoxy, (cycloalkyl)alkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, (heterocycloalkyl)alkyl, (heterocycloalky^allcoxy, (heterocycloalkyl)alkylsulfanyl, aryl, aryloxy, arylsulfanyl, aralkyl, aralkyloxy, aralkylsulfanyl, arylalkenyl, arylalkynyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, heteroaralkyl, (heteroaryl)alkoxy, or (heteroaryl)alkylsulfanyl.
16. The method of claim 13, wherein the inhibitor has the structure shown in formula III
or a pharmaceutically acceptable salt or N-oxide thereof, wherein each OfXm-1, X111-2, X111-3, and Xm-4 is independently CRiπ"x or N, provided that only two of Xi11-], Xm-2, Xm-3, and Xm-4 can be N simultaneously; each OfYm-1 and Ym-2 is independently CRm"y or N, provided that at least one Of Y1n-1 and Ym-2 must be N; each R111"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, allcylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfatrxide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; each R111"2 is independently alkyl, alkenyl, alkynyl, acyl, halo, hydroxy, -NH2, -NH(alkyl), -N(alkyl)2, -NH(cycloalkyl), -N(alkyl)(cyclocalkyl), -KHCheterocycloalkyl), -NH(heteroaryl), -NH-alkyl-heterocycloalkyl, -NH-alkyl-heteroaryl, -NH(aralkyl), cycloalkyl, (cycloalkyl)alkyl, aryl, aralkyl, aroyl, heterocycloalkyl, (lieterocycloalkyl)alkyl, heteroaryl, heteroaralkyl, heteroaroyl, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkoxy, cycloalkyloxy, (cycloalkyl)alkoxy, aryloxy, arylalkoxy, heterocycloalkyloxy, (heterocycloalkyl)alkoxy, heteroaryloxy, heteroarylalkoxy, alkylsulfanyl, cycloalkylsulfanyl, (cycloalkyl)alkylsulfanyl, arylsulfanyl, aralkylsulfanyl, heterocycloalkylsulfanyl, (heterocycloalkyl)alkylsulfanyl, heteroarylsulfanyl, heteroarylalkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl;, aminosulfonyl, alkylcarbonylamino, cycloalkylcarbonylamino, (cycloalky^alkylcarfconylamino, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalkytycarbonylamino, (heterocycloalky^alkylcarbonylamino, heteroarylcarbonylamino, heterόara'lkylcarB'o'n^
(heteroaryl)arylcarbonylaminoalkylamino, heteroaralkylcarbonylaminoalkylamino, (heteroary^arylsulfonylaminoalkylcarbonylaminoalkylamino, arylsulfonylaminoalkylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, or carbamoyl; m is 0, 1, 2, 3, or 4, and when m ≥2, two adjacent R111"1 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; n is 0, 1, 2, or 3, and when n >2, two adjacent R111"2 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; arid each of Rm~x and Rm"y is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, cycloalkylcarbonyl, (cycloalkyl)alkylcarbonyl, aroyl, aralkylcarbonyl, heterocycloalkylcarbonyl, (heterocycloalkyl)acyl, heteroaroyl, (heteroaryl)acyl, aminocarbonyl, alkylcarbonylamino, (amino)aminocarbonyl, alkylsulfonylaminocarbonyl, alkylsulfonylamino, cycloalkylcarbonylamino, cycloalkylsulfonylamino, (cyclo alkyl) alkylcarbonylamino, (cycloalkyl)alkylsulfonylamino, arylcarbonylamino, arylsulfonylamino, aralkylcarbonylamino, aralkylsulfonylamino, (heterocycloalkytycartoonylamino, (heterocycloalky^sulfonylamino, (heterocycloalky^alkylcarboiiylamino, (heterocycloalky^alkylsulfonylamino, heteroarylcarbonylamino, heteroarylsulfonylamino, heteroaralkylcarbonylanαino, heteroaralkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, (cycloalkyl)alkyl, (cycloalkyl)alkoxy, (cycloalkyl)alkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, (heterocycloalkyl)alkyl, (heterocycloalkyl)alkoxy, (heterocycloalkyl)alkylsulfanyl, aryl, aryloxy, arylsulfanyl, aralkyl, aralkyloxy, aralkylsulfanyl, arylalkenyl, arylalkynyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, heteroaralkyl, (heteroaryl)alkoxy, or (heteroaryl)alkylsulfanyl; or a pharmaceutically acceptable salt or N-oxide thereof.
17. The method of claim 13, wherein the inhibitor has the structure shown in formula IV
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein each RIV"a is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
RWA is a bond, alkylene, alkenylene, alkynylene, or -(CH2)rl-O-(CH2)r2-, where each of rl and r2 is independently 2 or 3;
Rw~2 is cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, or a bond;
R^3 is -C(O)-, -C(O)O-, -OC(O)-, -C(O)-N(R1^)-, -N(R1^)-C(O)-, -0-C(O)-N(R^' b)-, -N(R1^)-C(O)-O-, -0-S(O)P-N(R^)-, -N(R1^)- S(0)p-0-, -N(RIV'b)-C(0)-N(RIV-c)-, -N(RIV"b)-S(0)p-N(RIV-b)-, -C(O)-N(R^)-S(O)P-, -S(OVN(R1^)-C(O)-, -S(OVN(R1^)-, -N(R1^)-S(OV, -N(R1^)-, -S(0)p-, -0-, -S-, or -(C(RIY"b)(Rrv"c))q-, or a bond; wherein each of R iv-b an^ ^TV-C -s independently hydrogen, hydroxy, alkyl, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; wherein p is 1 or 2 and q is 1-4;
Rw~4 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl;
R™"5 is hydrogen, unsubstituted alkyl, halo-substituted alkyl, alkoxy, alkylsulfmyl, amino, alkenyl, alkynyl, cycloalkyl, cycloalkoxy, cycloalkylsulfinyl, heterocycloalkyl, heterocyclόali-bxy^Εeϊerocyclbalkylsiilfinyl, aryl, aryloxy, arylsulfinyl, heteroaryl, heteroaryloxy, or heteroarylsulfmyl;
Rw"6 is (1) a 5- to 6-membered heterocyclyl containing 1-3 hetero ring atoms selected from the group consisting of-O-, -S-, -N=, and -NR^-, wherein K1^'0 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroaralkyl; said heterocyclyl being substituted with R17"6 and optionally substituted with one to two R17^; where R17"6 is oxo, thioxo, alkoxy, alkylsulfinyl, -NH2, -NH(unsubstituted alkyl), or -N(unsubstituted alkyl)2, and R1^ is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, hetero arylsulfanyl, or heteroaroyl; or
(2) a fused ring heteroaryl selected from the group consisting of:
wherein ring A is an aromatic ring containing 0-4 hetero ring atoms, and ring B is a 5- to 7- membered aromatic or nonaromatic ring containing 0-4 hetero ring atoms, provided that at least one of ring A and ring B contains one or more hetero ring atoms; ring A' is an aromatic ring containing 0-4 hetero ring atoms, and ring B' is a 5- to 7-membered saturated or unsaturated ring containing 0-4 hetero ring atoms, provided that at least one of ring A' and ring B' contains one or more hetero ring atoms; each hetero ring atom is -O-, -S-, -N=, or - NR
1^s each X
1 is independently N or C; each X
2 is independently -O-, -S-, -N=, -NR
17"6-, or -CHR
17"11-; wherein R
w'g is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroaralkyl; each of R
17* and R™
"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cyc!oalfcyl,
''cycl6affyTδxy,
' cyclόalkyl
'sulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; and n is 0-2; and m is 0-3, and when m >2, two adjacent R™
"* groups can optionally join together to form a 4- to 8-memberecL optionally substituted cyclic moiety; provided that if R™
"6 is 2-naphthyridinyl, 4-quinolinyl, imidazo[l,2-a]pyriciyl, or benzimidazolyl, then -R^'-R^-R^-R^ is not H, unsubstituted alkyl, -CH
2-C(O)-N(H)-alkyl, -CH
2-C(O)-N(alkyl)
2, or benzyl.
18. The method of claim 13, wherein the inhibitor has the structure shown in fonnula V
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein
Rv'! is heteroaryl; each Rv"a, independently, is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, tliioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylainino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfarnoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
Xv is cycloalkyl., heterocycloalkyl, aryl, heteroaryl, or a bond;
Yv is a bond, -C(O)-, -C(O)-O-, -O-C(O)-, -S(O)P-O-, -O-S(O)P-, -C(0)-N<Rb)-, -N(Rb)-C(0)-, -O-C(O)-N(Rb)-, -N(Rb)-C(0)-0-, -C(O)-N(Rb)-O-, -O-N(Rb)-C(O>)-, -O-S(O)p-N(Rb)-, -N(Rb> S(O)p-O-, -S(O)p-N(Rb)-O-, -O-N(Rb)-S(O)p-, -N(Rb)-C(O)-N(Rc)-, -N(Rb)-S(0)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb)-C(O)-, -C(0)-N(Rb)-S(O)p-N(Rc)-, -C(O)-O-S(O)p-N(RDK -N(Ri3)-S(0);^N(R.c)-C(O)-, -N(Rb)-S(O)p-O-C(O)-, -S(O)p-N(Rb)-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)p-, -O-, -S-, or -(C(Rb)(Re))q-, wherein each of Rb and Rc, independently, is hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; wherein p is L or 2 and q is 1-4;
Rv"2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl; each of Av"1 and Av~2, independently, is N or NRb; and m is 0, 1, 2, or 3, and when m >2, two adjacent Rv"a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety, provided that if Xv is a bond, then Yv is a bond; R ,V-2 is hydro gen or alkyl; m is 1 , 2, or 3 ; and at least one R V- 'aa is substituted at the 2-pyrimidinyl position.
19. The method of claim 13, wherein the inhibitor has the structure shown in formula VI:
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein each R
VI"a, independently, is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, - NH
2, -NH(unsubstituted alkyl), -N(unsubstituted alkyl)
2, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, tieteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
"R
VIJ1 aϊkenylene, alkynylene, or -(CH
2)
ri-O-(CH
2)
r2-, wherein each of rl and r2, independently, is 2 or 3;
RYI~2 is cycloalkylene, heterocycloalkylene, cycloalkenylene, heterocycloalkenylene, arylene, heteroarylene, or a bond;
RVI"3 is -C(O)-, -C(O)-O-, -0-C(O)-, -S(O)p-O-, -O-S(O)P-, -C(O)-N(Rb)-, -N(Rb)-C(0)-, -O-C(O)-N(Rb)-, -N(Rb)-C(0)-0-, -C(0)-N(Rb)-0-, -O-3^(Rb)-C(O)-3 -O-S(O)p-N(Rb)-,
-N(Rb)- S(O)p-O-, -S(O)p-N(Rb)-O-, -O-N(Rb)-S(O)p-, -N(Rb)-C(0)-N(Rc)-, -N(Rb)-S(0)p-N(Rc>, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb)-C(O)-, -C(O)-N(Rb)-S(O)p-N(Rc)-, -C(O)-O-S(O)p-N(Rb)-, -N(Rb)-S(0)p-N(Rc)-C(0)-, -N(Rb)-S(O)p-0-C(O)-, -S(O)p-N(Rb)-, -N(Rb)-S(0)p-, -N(Rb)-, -S(OV, -0"» -S-= -(C(Rb)(Rc))q-, or a bond; wherein each of Rb and Rc is independently hydrogen, hydroxy, alkyl, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; wherein p is 1 or 2 and q is 1-4;
RVI"4 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl) alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl;
RVI"5 is hydrogen, unsubstituted alkyl, halo-substituted alkyl, alkoxy, alkylsulfinyl, amino, alkenyl, alkynyl, cycloalkoxy, cycloalkylsulfinyl, heterocyclo alkoxy, heterocycloalkylsulfinyl, aryloxy, arylsulfinyl, heteroaryloxy, or heteroarylsulfinyl;
RVI"6 is a 5- to 6-membered monocyclic heterocyclyl or an 8- to 11-membered bicyclic heteroaryl; each being optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; and m is 0-3 and when m ≥2, two adjacent RVI'a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety.
20. The method of claim 13, wherein the inhibitor is
1) 4-(4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)- lH-imidazol-2-yl)-piperidine- 1 - carboxylic acid benzyl ester; 2) 4-(4-BerizoiiV3ldioxol-5-yl-51-pyri3in-2-yl-lH-imidazol-2-yl) acid benzyl ester;
3) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-pipeτidine-l- carboxylic acid benzyl ester;
4) 3-[4-Beiαzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-pyrrolidine-l- carboxylic acid benzyl ester;
5) 2-(5-Benzo[ 1 J3]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-6-methyl-pyridine; 6) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid benzyl ester;
7) 3-[4-Berαzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
8) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-pyrrolidine-l- carboxylic acid benzyl ester;
9) 2-(5-Benzo[l,3]dioxol-5-yl-2-piperidm-4-yl-3H-imidazol-4-yl)-6-methyl-pyridine;
10) 2-[5 -B enzo [ 1 ,3] dioxol-5 -yl-2-( 1 -phenylmethanesulfonyl-piperidin-4-yl)-3 H-imidazol-4- yl] -6-metrryl-pyridine;
11 ) 2- [5 -B enzo [1,3] dioxol-5 -yl-2-( 1 -phenylmethanesulfonyl-piperidin-4-yl)-3 H-imidazol-4- yl]-pyridine;
12) 2-[5 -B enzo [1,3] dioxol-5-yl-2-( 1 -methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
13) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6- methyl-pyridine ;
14) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 2-chloro-benzyl ester;
15) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 2,4-dichloro-benzylamide;
16) l-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-L -yl]- ethanone;
17) 2-[5-B enzo[ 1 ,3]dioxol-5-yl-2-(l -furan-2-yl-methyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
18) {4-[4-Ηenzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-cyclohexyl} - carbamic acid benzyl ester;
19) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl] cyclohexylamine; 20) N-'{4-[4-Benzo[i,3]dioxol-5-yl-5-(6-methyl-pyridm-2-yl)-lH-imidazol-2-yl]- cyclohexyl}-C-phenyl-methanesulfonamide;
21) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
22) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
23) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-carbamic acid benzyl ester;
24) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-ethyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
25) 2-(5-Benzo[l,3]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-pyridine;
26) 4-(4-Benzo[ 1 ,3] dioxol-5 -yl-5 -pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid 4-nitro-benzyl ester;
27) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4,5-dimethoxy-2-nitro-~benzyl ester;
28) 4-(4-Benzo [ 1 ,3] dioxol-5 -yl-5 -pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid 3-fluoro-benzylamide;
29) 4-(4-Benzo[ 1 ,3] dioxol-5 -yl-5 -pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid 4-fluoro-benzylamide;
30) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid benzylamide;
31) 2-{5-Benzo[l)3]dioxol-5-yl-2-[l-(toluene-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}- pyridine;
32) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-methyl-benzylamide;
33) 4-(4-Benzo [ 1 ,3] dioxol- 5 -yl-5 -pyridin-2-yl- lH-imidazol-2-yl)-piperidine- 1 -carboxylic acid 4-methoxy-benzylamid.e;
34) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 2-chloro-benzylamide;
35) 4-[4-(4-Benzo[l,3]diox:ol-5-yl-5-pyridin-2-yHH-imidazol-2-yl)-piperidine-l-sulfonyl]- benzoic acid;
36) 4-(4-Benzo[ 1 ,3]dioxol- 5-yl-5-pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid amide; 37) 4-[4-(4-Benzo[l,3]dioxiol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidme-l-sulfonyl]- benzonitrile; 38) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloτo-benzenesulfonyl)-ρiperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
39) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,4-dichloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
40) {5-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-sulfonyl]- naphthalen- 1 -yl} -dimethyl-amine;
41) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-4-yl-methyl)-piperidin-4-yl)]-3H-imidazol-4- yl} -pyridine;
42) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
43) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-methoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
44) l-{4-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l- sulfonyl]-phenyl}-ethanone;
45) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-mettiyl-benzyl)-ρiperidm-4-yl]-3H-imidazol-4-yl}- pyridine;
46) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3-fluoro-5-trifluoromethyl-benzyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
47) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-cyclohexylmethyl-piperidm-4-yl)-3H-imidazol-4-yl]- pyridine;
48) 2-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-l-ylmethyl]- cyclopropanecarboxylic acid ethyl ester;
49) 2-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-l-ylmethyl]- pyrrolidine- 1-carboxylic acid tert-butyl ester;
50) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(2,2-dirnethyl-[ 1 ,3]dioxolan-4-ylmethyl)-piperidin-4- yl] -3H-imidazol-4-yl} -pyridine;
51) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-ethanes-ulfonyl-piρeridin-4-yl)-3H-imidazol-4-yl]- pyridine;
52) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(butane- 1 -sulfonyl)-piρeridin-4-yl]-3H-imidazol-4-yl} - pyridine;
53) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
54) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-pherxyl-ethenesulfonyl)-piperidin-4-yl]-3H-imidazol-
4-yl} -pyridine; 55) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(propane-l-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
56) l-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l- sulfonylmethyl]-7,7-dimethyl-bicyclo[2.2.1]heptan-2-one;
57) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
58) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl} -pyridine;
59) 2- { 5 -Benzo[ 1 ,3] dioxol-5 -yl-2-[ 1 -(4-fluoro-phenylmethanesulfbnyl)-piperidin-4-yl] -3H- imidazol-4-yl} -pyridine;
60) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(3,4-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl} -pyridine;
61) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol-
4-yl} -pyridine;
62) 2-[5 -Benzo[l,3]dioxol-5-yl-2-(l-p-tolylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl] -pyridine;
63) 3-(4-Benzo[ 1 ,3]dioxol-5-yl- 1 -hydroxy-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidine- 1 - carboxylic acid benzyl ester;
64) 3-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid benzyl ester;
65) 4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1 -carboxylic acid benzyl ester;
66) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(pyridin-2-yl-methanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
67) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-naphthalen-l-yl-ethanesulfonyl)-piperidin-4-yl]-3H- imidazo 1-4-yl} -pyridine;
68) 2-[5 -Benzo[l ,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-3-yl)-3H-imidazol-4- yl] -pyridine;
69) 3-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-metliyl-pyridin-2-yl)-lH-iniidazol-2-yl]- piperidine-1 -carboxylic acid benzyl ester;
70) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(pyridin-4-yl-methanesulfonyl)-piperidin-4-yl]-3H- imidazo 1-4-yl} -pyridine;
71) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(pyridin-3-yl-methanesulfonyl)-piperidin-4-yl]-3H- imidazo 1-4-yl} -pyridine; 72) 2-{5-Benzotr'3']ϊϊoxoϊ:'S-yl-'2-[l-(3-trifluoromethyl-phenylmethan yl]-3H-imidazol-4-yl} -pyridine;
73) 3-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- pyrrolidine- 1-carboxylic acid benzyl ester;
74) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4- yl] -3H-imidazol-4-yl} -pyridine;
75) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-bis-trifluoromethyl-phenylmethanesulfonyl)- piperidin-4-yl]-3H-imidazol-4-yl} -pyridine;
76) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l -(biphenyl-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
77) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl} -pyridine;
78) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-2-yl-methanesulfonyl)-ρiperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
79) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(4-phenoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
80) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(biphenyl-4-ylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
81) 4-[5-Benzo[l,3]dioxol-5-yl-l-methyl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine- 1-carboxylic acid benzyl ester;
82) 4-[4-Benzo[l,3]dioxol-5-yl-l-methyl-5-(6-methyl-ρyridin-2-yl)-lH-iniidazol-2-yl]- piperidine- 1-carboxylic acid benzyl ester;
83) {4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexyl}-carbamic acid benzyl ester;
84) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(3-phenoxy-phenylmethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl}-6-methyl-pyridine;
85) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-ethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
86) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(propane-l-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
87) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(butane-l-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}- 6-methyl-pyridine;
88) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l -(pyridin-3-ylmethanesulfonyl)-ρiperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine; 89) 2-{5-Benzo[L3]'^^ imidazol-4-yl} -6-methyl-pyridine;
90) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
91) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(3-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4- yl] -3H-imidazol-4-yl} -6-methyl-pyridine;
92) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(thiophene-2-sulforiyl)-piperidm-4-yl]-3H-irnidazol-4- yl} -6-methyl-pyridine;
93) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(butane-l-sulfonyl)-piperidin-3-yl]-3H-imidazol-4-yl}-
6-methyl-pyridine;
94) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-3-yl)-3H-imidazol-4- yl] -6-methyl-pyridine;
95) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(l-methyl-lH-imidazole-4-sulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
96) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(5-methyl-isoxazole-4-sulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
97) 4-[5-Benzo[l,3]dioxol-5-yl-l-hydroxy-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
98) Butane- 1 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-cyclohexyl} -amide;
99) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-iniidazol-2-yl]- cyclohexyl}-C-pyridin-2-yl-methanesulfonamide;
100) Thiophene-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-cyclohexyl}-amide;
101) 1 -Methyl- lH-imidazole-4-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl- pyridin-2-yl)-lH-imidazol-2-yl]-cyclohexyl}-amide;
102) 4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
103) 4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
104) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-bromo-pyridin-2-y"l)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
105) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(thiophene-3-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine; 106) 2-'{5-Benzorø]dϊrø piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
107) 4-[2-(l-phenylmethanesulfonyl-piperidin-4-yl)-5-(6-methyl-pyridin-2-yl)-lH-imidazol-
4-yl]-pyridin-2-yl-fluoride;
108) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-trifluoromethyl-pyridin-2-yl)- lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
109) 4- [ 5 -B enzo [1,3] dioxol-5 -yl-4-(6-bromo-pyridin-2-yl)- 1 -hydroxy- 1 H-imidazol-2-yl] - piperidine-1-carboxylic acid benzyl ester;
110) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl] -6-bromo-pyridine;
111) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2]oct-l -yl} -methanol;
112) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
113) 4- [4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-2H-imidazol-2-yl]-piperidine- 1 - sulfonic acid dimethylamide;
114) 1- {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-irnidazol-2-yl]-piperidin- l-yl}-3-phenyl-propan-l-one;
115) 2- {5-Benzo[l,3]dioxol-5-yl-2-[l-(propane-2-sulfonyl)-piperidiii-4-yl]-3H-imidazol-4- yl}-6-methyl-pyridine; 116) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imi(lazol-2-yl]- bicyclo [2.2.2]octane-l -carbonitrile;
117) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imi(lazol-2-yl]- bicyclo[2.2.2]oct-l-ylamine;
118) N- {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-iinidazol-2-yl]- bicyclo [2.2.2] oct- 1 -yl} -C-phenyl-methanesulfonamide;
119) N- {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2] oct- 1 -yl} -methanesulfonamide;
120) N- {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2]oct- 1-yl} -C-pyridin-2-yl-methanesulfonamide;
121) 2- {5-Benzo[l,3]dioxol-5-yl-2-[4-(lH-tetrazol-5-yl)-bicyclo[2.2.2]oct-l-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
122) N- {4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetamide; 123) Thiophene-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl}-amide;
124) l-Methyl-lH-imidazole-4-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl- pyridin-2-yl)-lH-imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl}-amide;
125) Thiophene-3 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl}-amide;
126) 2- {5-Benzo[ 1 ,3]dioxo l-5-yl-2-[ 1 -(2-phenyl-ethenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl}-6-methyl-pyridine;
127) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(2-ρhenyl-ethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
128) Methanesulfonic acid 4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl] -bicyclo[2.2.2] oct- 1 -ylmethyl ester;
129) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetonitrile;
130) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetic acid;
131) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l -ylmethyl} -methanesulfonamide;
132) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(biphenyl-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
133) 2-{5 -Benzo [1,3] dioxo 1-5 -yl-2- [ 1 -(4-phenoxy-benzenesulfonyl)-piperidin-4-yl] -3H- imidazol-4-yl} -6-methyl-pyridine;
134) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(3,4-dichloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
135) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct- 1 -ylmethyl} -C-phenyl-methanesulfonamide; 136) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l -ylmethyl} -C-pyridin-2-yl-methanesulfonamide; 137) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid benzylamide;
138) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (pyridin-2-ylmethyl)-amide; 139) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid 3-chloro-4-fluoro-benzylamide; 140) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6'-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (furan-2-ylmethyl)-amide;
141) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfonyl-pyrrolidin-3-yl)-3H-imidazol-4-yl]-6- methyl-pyridine ;
142) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(butane- l-sulfonyl)-pyrrolidin-3-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
143) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(l-methyl-lH-imidazole-4-sulfonyl)-pyrrolidm-3-yl]- 3H-imidazol-4-yl} -6-methyl-pyridine;
144) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylnxethanesulfonyl-pyrrolidin-3-yl)-3H-imidazol- 4-yl] -6-methyl-pyridine;
145) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(4-chloro-benzenesulfonyl)-pyrrolidin-3-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
146) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
147) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-naphtlialen-2-yl-ethanesulfonyl)-piperidm-4-yl]- 3H-imidazol-4-yl}-6-methyl-pyridine;
148) l-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine- l-sulfonylmethyl}-7,7-dimethyl-bicyclo[2.2.1]lieptan-2-one;
149) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
150) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methylamide;
151) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid ethylamide;
152) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid butylamide;
153) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid isopropylamide; 154) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (3-imidazol-l-yl-propyl)-amide; 155) 2-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine- 1 -sulfonylmethyl} -phenylamine;
156) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (l-methyl-5-methylsulfanyl-lH-[l,2,4]triazol-3-yl)- amide; 157) 4-[4-Benzo["ϊ ,3]dioxol-5-yr-5-(d':methyl-pyridin-2-yl)- lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid cyclohexylamide;
158) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct- 1 -yl} -pyrrolidin- 1 -yl-methanone;
159) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid dimethylamide;
160) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid diethylamide;
161) 4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-meth.yl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid dipropylamide;
162) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lEi-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid (5,7-difluoro-benzothiazol-2-yl)-arnide; 163) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid benzothiazol-2-ylamide; 164) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lEi-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (lH-benzoimidazol-2-yl)-amide; 165) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (2-hydroxy-l-methyl-2-phenyl-ethyl)-amide; 166) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid (pyridin-4-ylmethyl)-amide;
167) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin-l- yl } -(3 -chloro-phenyl)-methanone;
168) {4-[4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)- 1 H-imidazol-2-yl]-piperidin- 1 - yl} -(4-fluoro-phenyl)-methanone;
169) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin-l- yl}-(4-methoxy-ρhenyl)-methanone;
170) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-cyclopropyl-pyridin-2-^l)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid;
171) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methoxy-amide;
172) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
173) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmetliyl}-carbamic acid benzyl ester; 174) 4'-[4-Benzo[l,'3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid hydrazide;
175) N- {4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl} -acetamide;
176) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethylj-methanesmfonarnide;
177) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmemylj-C-phenyl-rnethanesulfonamide;
178) Butane- 1 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl] -cyclohexylmethyl} -amide;
179) Propane-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-cyclohexylmethyl}-amide;
180) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohex:ylmethyl}-C-pyridin-2-yl-methanesulfonamide;
181)N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohex:ylmethyl}-C-pyridm-4-yl-methanesulfonamide;
182) (4-Methoxy-benzyl)- {4-[5-(6-methyl-pyridin-2-yl)-2-(l -phenylmethanesulfonyl- piperidin-4-yl)-lH-imidazol-4-yl]-pyridin-2-yl} -amine;
183) 4-[5-(6-Methyl-pyridin-2-yl)-4-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
184) 4-[5-(6-Methyl-pyridin-2-yl)-4-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
185) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
186) 4-[4-(6-Methyl-pyridin-2-yl)-5-[l52,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
187) 4-[4-(6-Methyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
188) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl- lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid;
189) N- -(4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridm-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-2,2,2-trifluoro-acetamide;
190) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol; 191) 4-[4-(6-Cyclopropyl-pyridiix-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carbox:ylic acid amide;
192) 4-[4-(6-Cyclopropyl-pyridirL-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carbox:ylic acid hydroxyamide;
193) N-{4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct- 1 -yl} -sulfamide;
194) Sulfamic acid 4-[4-benzo[1.3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl ester;
195) {4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl} - carbamic acid benzyl ester;
196) N- {4-[4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carbonyl} -methanesulfonamide;
197) N- {4-[4-Benzo[ 1 ,3]dioxol-5 -yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carbonyl} -benzenesulfonamide;
198) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester; 199) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid;
200) N-{4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl}- acetamide;
201) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane- 1-carboxylic acid methyl ester;
202) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane- 1-carboxylic acid;
203) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane- 1-carboxylic acid hydroxyamide;
204) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane- 1-carboxylic acid amide;
205) N-{4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl}- methanesulfonamide;
206) 2,2,2-Triiluoro-N-{4-[4-(6-inethyl-ρyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- cyclohexyl} -acetamide;
207) 4-[4-(5-Fluoro-6-methyl-pyτidin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol- 2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester; 208) {4-[2- [ 1 -(Butane- 1 -sύ"Iϊohyl)-pip"eridin-4-yl]-5 -(6-methyl-pyridin-2-yl)- 1 H-imidazol-4- yl]-pyridin-2-yl}-(4-methoxy-benzyl)-amine;
209) 4-[2-[l-(Butane-l-sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)-lH-imidazol-4- yl] -pyridin-2-ylamine;
210) 2-[5-Benzo[l ,3]dioxol-5-yl-2-(l -phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl]-6-ethyl-pyridine;
211) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
212) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
213) N- {4- [5-(6-Methyl-pyridin-2-yl)-4-quinoxalin-6-yl- 1 H-imidazol-2-yl] - bicyclo[2.2.2]oct-l-yl}-methanesulfonamide;
214) N-{4-[5-(6-Methyl-pyridin-2-yl)-4-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetamide.
215) 4-[2-(6-Methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyridin-3-yl]-pyrimidin-2-ylamine;
216) 4-(2-pyridin-2-yl-pyrazolo[l,5-a]pyridin-3-yl)-pyrimidin-2-ylamme;
217) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyridin-3-yl]-pyrimidin-2-ylamme;
218) 2-(6-methyl-pyridin-2-yl)-3-(2-methylsulfaxiyl-pyrimidin-4-yl)-pyrazolo[l,5-a]pyridine;
219) 4-[2-(6-chloro-pyridin-2-yl)-pyrazolo[l,5-c]pyrimidin-3-yl]-pyrimidin-2-ylamine;
220) 2-(6-methyl-pyridin-2-yl)-3-(2-moφholin-4-yl-pyrimidm-4-yl)-pyrazolo[l,5- c]pyrimidine;
221) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyrazin-3-yl]-pyrimidin-2-ylamine;
222) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[ 1 ,5-a]pyrimidin-3-yl]-pyrimidin-2-ylamine;
223) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-c]pyrimidin-3-yl]-pyrimidin-2-ylamine;
224) (2-Methoxy-ethyl)- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
225) (3- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-ρyrimidin-2-ylamino} - propyl)-carbamic acid tert-butyl ester;
226) (3-Imidazol-l-yl-propyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
227) (4-Methoxy-benzyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
228) [2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridin- 6-yl]-methanol; 229) 3-(2-Methanesulfonyl-^ a]pyridine;
230) (4-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- butyl)-carbamic acid tert-butyl ester;
231) (4-Amino-benzyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridm-3-yl]- pyrimidin-2-yl} -amine;
232) (5- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - pentyl)-carbamic acid tert-butyl ester;
233) [3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridin-6-yl]- methanol;
234) [3-(2-ammo-pyrimidin-4-yl)-2-(6-metriyl-pyridm-2-yl)-imidazo[l,2-a]pyridin-7-yl]- methanol;
235) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(2-moipholin-4-yl-ethyl)-amine;
236) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(2-pyridin-2-yl-ethyl)-amine;
237) [3-(2-Amino-pyrimidin-4-yl)-6-metriyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(2-pyridin-3-yl-ethyl)- amine;
238) [3 -(2-methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2- a]pyridm-6-yl]-methanol;
239) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(2-pyridin-4-yl-ethyl)-amine;
240) [3-(2-Amino-pyrimidin-4-yl)-6-metliyl-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridin-8-yl]-(3-morpholin-4-yl-propyl)-amine;
241) [3 -(4-Methyl-piperazin- 1 -yl)-propyl] - {4- [2-(6-methyl-pyridin-2 -yl)-imidazo [1,2- a]pyridin-3-yl]-pyrimidin-2-yl}-amine;
244) [3-(4-Methyl-piperidm-l-yl)-propyl]-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-3-yl]-pyrimidin-2-yl}-amine;
245) [4-(2-Pyridin-2-yl-imidazo[l,2-a]pyridin-3-yl)-pyrimidin-2-yl]-pyridin-3-ylmetriyl- amine;
246) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrirnidin-2-yl}-((R)-l- phenyl-ethyl)-amine;
247) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrirnidin-2-yl}-((S)-l- phenyl-ethyl)-amine; 248) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-yl} -(1H- tetrazol-5-yl)-amine;
249) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2H- pyrazol-3 -yl)-amine;
250) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2- moφholin-4-yl-ethyl)-amine;
251) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2-pyriciin- 2-yl-ethyl)-amine;
252) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2-pyrid.in- 3 -yl-ethyl)-amine;
253) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2-pyridin- 4-yl-ethyl)-amine;
254) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(3- moφholin-4-yl-propyl)-amine;
255) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(3- piperidin- 1 -yl-propyl)-amine;
256) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidm-2-yl}- [1,3 ,4]thiadiazol-2-yl-amine;
257) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyτiciine;
258) 2-(6-Methyl-pyridin-2-yl)-3-(2-meth.ylsulfanyl-pyrimidm-4-yl)-iniidazo[l,2-a]pyrid.ine- 6-carboxylic acid methyl ester;
259) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-iinidazo[l,2-a]pyriciine- 7-carboxylic acid ethyl ester;
260) 2-(6-Methyl-pyridin-2-yl)-3-(2-metriylsulfanyl-pyrirnidin-4-yl)-irriidazo[l,2- a]pyrimidin-7-ylamme;
261) {7,7-Dimethyl-8-[5-(4-{4-[2-(6-methyl-ρyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ylamino} -butylcarbamoyl)-p entyl]-2-oxo-4-trifluoromethyl-7,8-dihydro-2H[- 1 - oxa-8-aza-anthracen-5 -yl} -methanesulfonic acid;
262) 2-(2,7-Difluoro-6-hydroxy-3-oxo-9,9a-dihydro-3H-xanthen-9-yl)-3,5,6-trifluoro-4-[(4-
{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- butylcarbamoyl)-methylsulfanyl] -benzoic acid;
263) -(6-Methyl-pyridiri-2-yl)-3-(2-morpholin-4-yl-pyrirnidin-4-yl)-irnidazo[ 1 ,2-a]pyridine;
264) 2-(6-Methyl-pyridin-2-yl)-3-(2-piperidin-l-yl-pyrimidiri-4-yl)-irnidazo[l,2-a]pyridάne;
265) 2-(6-Methyl-pyridin-2-yl)-3 -(2-pyrrolidin- 1 -yl-pyrimidin-4-yl)-imidazo [ 1 ,2-a]pyridine; 266) 2-(6-Methyl-ρyridin-2-yl)-3-[2-(l H-tetrazol-5-yl)-ρyrimidin-4-yl]-imidazo[ 1 ,2- a]pyridine;
267) 2-(6-Methyl-pyridin-2-yl)-3 -pyrimidin-4-yl-imidazo[ 1 ,2-a]pyridine; 268) 2-(6-Methyl-pyridin-2-yl)-3-pyrimidin-4-yl-imidazo[l,2-a]pyrimidin-7-ylamine; 269) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-8- ylamine;
270) 3-(2-Amino-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carbonitrile;
271) 3-(2-Amino-pyrimidin-4-yl)-2-(6-metliyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid;
272) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l52-a]pyridine-6- carboxylic acid ([l,4]dioxan-2-ylmethyl)-aniide;
273) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide;
274) 3 -(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid (2-dimethylamino-ethyl)-amide;
275) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid (2-methoxy-ethyl)-amide;
276) 3 -(2-Amino-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridine-6- carboxylic acid (2-thioplien-2-yl-ethyl)-amide;
277) 3-(2-Amino-pyrimidin-4-yl)-2-(6-niethyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid [3-(4-methyl-piperazin-l-yl)-propyl]-amide;
278) 3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid amide;
279) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid cyclopropylamide;
280) 3-(2-Amino-pyrirnidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid ethylamide;
281) 3-(2-Amino-pyrimidm-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridirie-6- carboxylic acid hydroxyamide;
282) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid methoxy-amide;
283) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-irriidazo[l,2-a]pyridine-6- carboxylic acid methyl ester; 284) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid;
285) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide;
286) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (2-amino-ethyl)-amide;
287) 3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (2-dimethylamino-ethyl)-amide;
288) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2- a]pyridine-7- carboxylic acid (2-hydroxy-ethyl)-amide;
289) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2- a]pyridine-7- carboxylic acid (2-oxo-2-pyridin-3-yl-ethyl)-amide;
290) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridine-7- carboxylic acid (2-thiophen-2-yl-ethyl)-amide;
291) 3-(2-Amino-pyrimidin-4-yl)-2-(6-metriyl-pyridin-2-yl)-irαidazo[l ,2- a]pyridine-7- carboxylic acid (piperidin-3-ylmethyl)-amide;
292) 3-(2-Amino-pyrimidin-4-yl)-2-(6-metliyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridine-7- carboxylic acid 2,2-dimethylhydrazide;
293) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridine-7- carboxylic acid amide;
294) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2- a]pyridine-7- carboxylic acid cyclopropylamide;
295) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[ 1 ,2- a]pyridine-7- carboxylic acid ethyl ester;
296) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid ethylamide;
297) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid hydroxyamide;
298) 3-(2-Arnino-pyriniidin-4-yl)-2-(6-methyl-pyridm-2-yl)-irnidazo[l,2-a]pyridirie-7- carboxylic acid methoxy-amide;
299) 3-(2-Amino-pyrimidin-4-yl)-2-(6-metriyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyrimidin-7- ylamine;
300) 3-(2-Azetidin-l-yl-pyrimidin-4-yl)-2-(6-rnethyl-pyridin-2-yl)-imida2o[l,2-a]pyridine; 301) 3-(2-Methanesulfonyl-pyrirnidin-4-yl)-2-(6-methyl-pyridin-2-yl)-inxidazo[l,2-a] pyridine-7-carboxylic acid ethyl ester; 302) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridine-6-carboxylic acid methyl ester;
303) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-7-rnethyl-2-(6-methyl-pyridin-2-yl)-iinidazo[l,Z- a] pyridine;
304) 3-(2-Methanesulfonyl-p3θimidin-4-yl)-8-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a] pyridine;
305) 3,3-Dimethyl-N-[2-(6-inethyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)- imidazo[l,2-a]pyrimidin-7-yl]-butyr amide;
306) 3-(2-Methanesulfonyl-pyriniidin-4-yl)-2-(6-niethyl-pyridin-2-yl)-imidazo[l,2- a]pyridine-6-carbonitrile;
307) 3-(2-Methylsulfanyl-pyrimidin-4-yl)-2-pyridin-2-yl-imidazo[l,2-a]pyridine;
308) 3,6-Dichloro-N-(4- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]- pyrimidin-2-ylamino}-butyl)-2-(2,4,5,7-Tetracliloro-6-hydroxy-3-oxo-9,9a-dihydro-3H- xanthen-9-yl)-terephthalamic acid;
309) 3-[2-(2-Methyl-aziridin-l-yl)-pyrimidin-4-yl]-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a_] pyridine;
310) 3-[2-(4-Methyl-piperazin- 1 -yl)-pyrimidin-4-yl]-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a] pyridine;
311) 3-{[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carbonyl]-amino} -propionic acid methyl ester;
312) 3-{[3-(2-Amino-pyrimi<im-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridine-7- carbonyl]-amino} -propionic acid methyl ester;
313) 3- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - phenol;
314) 4-(2- {4-[2-(6-Methyl-p3rridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - ethyl)-benzenesulfonamide;
315) 4-(2-Pyridin-2-yl-imidazo[l ,2-a]pyridin-3-yl)-pyrimidin-2-ylamine; 316) 4-[2-(6-Chloro-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamine;
317) 4-[2-(6-Methyl-pyridin-2-yl)-7-trifluoromethyl-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin— 2-yl- amine;
318) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamine;
319) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidine-2-carbonitrile;
320) 4-[2-(6-Methyl-pyridin.-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidine-2-carboxylic acid amide; 32Ϊ) 4-[6-Bromo-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
322) 4-[6-Chloro-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
323) 4-[6-Fluoro-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
324) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-morpholin-4-yl-etliylamino)-imidazo[l,2-a] pyridin-3 -yl] -pyrimidin-2-ol;
325) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-2-yl-ethylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidin-2-ol;
326) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-3-yl-ethylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidin-2-ol;
327) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-4-yl-ethylamino)-imidazo[ 1 ,2-a] pyridin-3 -yl] -pyrimidin-2-ol;
328) 4-[6-Methyl-2-(6-methyl-pyridm-2-yl)-8-morpholin-4-yl-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ol;
329) 4-[6-Methyl-2-(6-metriyl-pyridin-2-yl)-8-morpholm-4-yl-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ylamine;
330) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
331) 4-[7-Aminomethyl-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2- yl-amine;
332) 4-[7-Methyl-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridin-3 -yl] -pyrimidin-2- ylamine;
333) 4-[8-Benzyloxy-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ol; 334) 4-[8-Benzyloxy-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl- amine;
335) 4-[8-Bromo-6-methyl-2-(6-methyl-pyridin-2-yl)-imidaz;o[l,2-a]pyridin-3-yl]-pyrimidin- 2-ol;
336) 4-[8-Methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]p3τidin-3-yl]-pyrimidin-2- ylamine;
337) 6-Chloro-3-(2-methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a] pyridine;
338) 5-Dimethylamino-naphthalene-l -sulfonic acid (4-{4-[2-(6-methyl-pyridin-2-yl)- imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} -butyl)-amide; 339) 6-(2J-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-N-(4-{4-[2-(6-rnetliyl-ρyridm-2-yl)- imidazo[l,2-a]pyridin-3-yl]-pyrimidm-2-ylamino}-butyl)-isophthalamic acid;
340) 6-Ammo-9-[2-carboxy-5-(4-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[ l,2-a]ρyridin-3-yl]- pyrimidin-2-ylamino}-butylcarbamoyl)-phenyl]-xanthen-3-ylidene-ammonium;
341) 6-Bromo-2-(6-methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a] pyridine;
342) 6-Fluoro-2-(6-methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-'4-yl)-imidazo[l,2-a] pyridine;
343) 7-Amino-4-methyl-3-[(4-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ylammo}-butylcarbamoyl)-metliyl]-2-oxo-2H-chromene-6-sτilfoiiic acid;
344) Cyclobutyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-yl} - amine;
345) Cyclopentyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3 -yl]-pyrimidin-2- yl} -amine;
346) Cyclopropyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3 -yl]-pyrimidin-2- yl} -amine;
347) Cyclopropyl-methyl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
348) Dimethyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-yl} - amine;
349) Isopropyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-yl} - amine;
350) Methyl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- amine;
350a) N-(2- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-p3rrimidin-2- ylamino} -ethyl)-acetamide;
351) N-(4- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyτimidin.-2-ylamino} - butyl)-acetamide;
352) N,N-Dimethyl-Nl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-
2-yl} -ethane-1 ,2-diamine;
353) N-[2-(6-Metliyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a] pyrimidin-7-yl]-3-pyridin-3-yl-propionamide;
354) N-[2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a] pyrimidin-7-yl] -nicotinamide; 355) N-i2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidm-4-yl)-imidazo[l,2-a] pyrimidin-7-yl] -propionamide;
356) N-[3-(2-Amino-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-iinidazo[l,2-a]pyridine-6- carbonylj-methanesulfonamide;
357) N- [3 -(2- Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-iinidazo [ 1 ,2-a]pyridine-7- carbonyl] -methanesulfonamide;
358) N-[3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidin-7- yl]-2-(3-methoxy-phenyl)-acetamide;
359) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidin-7- yl] -3 ,3 -dimethyl-butyr amide;
360) N-[3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-iinidazo[l,2-a]pyrimidin-7- yl] -3 -pyridin-3 -yl-propionamide;
361 ) N-[3 -(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-iτnidazo [ 1 ,2-a]pyrimidin-7- yl]-acetamide;
362) N-[3 -(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyrimidin-7- yl] -nicotinamide;
363) N- [3 -(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a] pyrimidin-7 -yl] -2-(3 -methoxy-ρhenyl)-acetamide;
364) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyri.din-2-yl)-imidazo[l,2-a] pyrimidin-7-yl]-3,3-dimethyl-butyramide;
365) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridiii-2-yl)-imidazo[l,2-a] pyrimidin-7-yl]-3-pyridin-3-yl-propionamide;
366) N-[3-(2-Methanesulfonyl-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7 -yl] -nicotinamide;
367) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7-yl] -propionamide;
368) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidin-7- yl] -propionamide;
369) N-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- acetamide;
370) Nl - {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3 -yl]-pyrimidin-2-yl} -butane-
1 ,4-diamine;
371) Nl-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- propane- 1 ,3-diamine; 372) N-(4- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - butyl)-(BODIPY FL) amide; and
373) N-(4- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - butyl)-(Texas Red-X) amide
374) N-[3-(2-ammo-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidin-7- yl]-acetamide;
375) N- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-yl} - acetamide.
376) 3-(3-pyridin-2-yl-4-qumolin-4-yl-pyrazol-l-yl)-propylamine,
377) N- [3 -(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol- 1 -yl)-propyl] -acetamide,
378) N-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propyl]-metlianesulfonamide,
379) dimethyl-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propyl]-amine,
380) 4-{3-pyridin-2-yl-l-[2-(lH-tetrazol-5-yl)-ethyl]-lH-pyrazol-4-yl}-quinoline,
381) 4-[3-pyridin-2-yl-l-(3-pyrrolidin-l-yl-propyl)-lH-pyrazol-4-yl]-quinoline,
382) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyridin-2-ylamine,
383) 2,4-dimethoxy-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyrimidine,
384) 3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propionic acid, 385) 5 -(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)- 1 H-indole, 386) 2-[4-(2,3-dihydro-benzo[l,4]dioxin-6-yl)-lH-pyrazol-3-yl]-pyridine, 387) N-hydroxy-3-(3-pyridm-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propionamide, 388) 2-(3 -pyridin-2-yl-4-quinolin-4-yl-pyrazol- 1 -yl)-ethylamine, 389) N-[2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-ethyl]-metlianesulfonamide, 390) 2-metliyl-4-methylsulfanyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyrimidine, 391) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-pyridine,
392) 2-[4-(2,3-dihydro-benzofuran-5-yl)-lH-pyrazol-3-yl]-pyridine,
393) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[d]isoxazole,
394) 3-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-proρionitrile, 395) N-{3-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-propyl}- methanesulfonamide,
396) 2-[4-(2,3-dihydro-benzo[l,4]dioxin-6-yl)-lH-pyrazol-3-yl]-6-methyl-pyridine, 397) [4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-acetonitrile, 398) N-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethyl}- methanesulfonamide,
399) 4-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-2-methylsulfanyl-pyrimidine,
400) 4-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-2H-phthalazin- 1 -one, 401) l-[5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-2,3-dihydro-indol-l-yl]-ethanone,
402) 6-(3-pyridin-2-yl- 1 H-pyrazol-4-yl)-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridine, 403) 3-methyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one, 404) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-4H-benzo[l,4]oxazin-3-one, 405) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinoxaline,
406) 3-(4-nitro-benzyl)-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
407) 5-methyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]pyridine,
408) 4-methyl-7-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3,4-dihydro-lH-benzo[e][l,4]diazepine-
2,5-dione,
409) 2,3-dimethyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
410) 6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine,
41 Oa) 1 -rriethoxy-4-(3-pyridin~2-yl-lH-pyrazol-4-yl)-isoquinoline,
411) 2-methyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]ρyridine,
41 Ia) 4-(3-pyridin-2-yl-lH-pyrazol-4-yl)-2H-isoquinolin-l-one,
412) 2-(4-benzo[ 1 ,3] dioxol-5 -yl- 1 H-pyrazol-3 -yl)-6-trifluoromethyl-pyridine,
412a) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-vinyl-pyridine,
413) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-propenyl-pyridine,
414) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-ethyl-pyridine,
415) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-propyl-pyridine,
416) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-cyclopropyl-pyridine,
417) l-[6-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-pyridin-2-yl]-ethanol,
418) 4-methoxy-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline,
419) 6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-quinoline,
420) 6-(3 -pyridin-2-yl-lH-pyrazol-4-yl)-quinazolin-4-ylamine, 421) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
422) 7-(3 -pyridin-2-yl-lH-pyrazol-4-yl)-pyrido[l,2-a]pyrimidin-4-one, 423) 6-[3-(6-cyclopropyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine, 424) 3-methyl-6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3H-quinazolin-4-one, 425) 4-(2-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethoxy}- ethoxy)-bicyclo[2.2.2]octane- 1 -carboxylic acid,
426) 4-(2-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethoxy} - ethoxy)-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester, 427) 4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester,
428) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-isopropyl-pyridine, 429) 2-(4-benzo[ 1 ,3]dioxol-5-yl-5-trifluoromethyl-lH-pyrazol-3-yl)-6-bromo-pyridine, 430) 6-[3-(5-fluoro-6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridirLe,
431) 6-[3-(6-trifluoromethyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l ,2,4]triazolo[l ,5-a]pyridine,
432) 6-[3-(6-methyl-pyridin-2-yl)- 1 H-pyrazol-4-yl]-quinoxaline,
432a) 6-[3-(6-cyclopropyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3-methyl-3H-quinazolin-4-oner, 433) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-b]pyridazine, 433a) 6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-quinoline, 434) 6-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-3-fluoro-2-methyl-pyridine,
435) 7-methoxy-3-methyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
436) (4-morpholin-4-yl-phenyl)-[6-(3-pyridin-2-yl-lH-ρyrazol-4-yl)-quinazolin-4-yl]-amine, 437) 4-isopropoxy-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline,
438) 6-(3-Pyridm-2-yl-lH-pyrazol-4-yl)-quinolin-4-ylamine,
439) {4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohexyl}- carbamic acid benzyl ester,
440) 4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohexylaini]χe, 441) N-{4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohexyl} - methanesulfonarnide,
442) 6-[3-(5-fluoro-6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-quinoxaline, 443) 7-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]pyridine,
444) l-tert-butyl-3-[6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolm-4-yl]-urea,
445) 5-(3-ρyridin-2-yl-lH-pyrazol-4-yl)-benzo[l ,2,5]thiadiazole,
446) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[l,2,5]oxadiazole,
447) 5-(3-Pyridin-2-yl-lH-pyrazol-4-yl)-benzooxazole, 448) 4-morpholin-4-yl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-q\iinazoline, 449) 6- [3 -(6-trifluoromethyl-pyridin-2-yl)- 1 H-pyrazol-4-yl] -quinoxaline, 450) 4-(4-methoxy-phenyl)-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolme, 451) 5-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-benzo[l,2,5]tbiadiazole,
452) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzothiazole,
453) 3-(3-methoxy-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
454) S-methyl-thiophene^-carboxylic acid [6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoLin-4- yl] -amide,
455) 5-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3-phenyl-benzo[c]isoxazole, 456) 3-(4-methoxy-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole, 457) 3-(4-chloro-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
458) 3 -(4-ethyl-phenyl)-5-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-benzo [cjisoxazole, 459) (4-methoxy-pE'enyϊ)- [6"-(3-pyridϊh-2-yl- 1 H-pyrazol-4-yl)-quinazolin-4-yl]-methanone,
460) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3-thiophen-3-yl-benzo[c]isoxazole,
461 ) 5 -(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)- 1 H-indazole-3 -carboxylic acid,
462) 5-(3-Pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid methylamide,
463) 5-(3-pyridiii-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid diethylamide,
464) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid (2,2-dimethyl- propyl)-amide,
465) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid phenylamide, 466) morpholin-4-yl-[5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazol-3-yl]-methanone,
467) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid benzylamide,
468) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid cyclopentylamide; 469) 4-[4-benzo[l,3]dioxol-5-yl-5-(2-methylsulfanyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- benzamide;
470) 4-[4-benzo[l,3]dioxol-5-yl-5-(2-methylsulfanyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- benzonitrile;
471) 4-[5-(2-methaiiesulfonyl-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
472) 4-[5-(2-methoxy-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2] octane- 1 -carboxylic acid methyl ester;
473) 4-[5-(2-hydroxy-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
474) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l -carboxylic acid methyl ester;
475) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid;
476) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)- 1 H-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
477) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
478) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methoxy-amide;
479) 4-[5-(2-ammo-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2] octane- 1 -carboxylic acid;
480) {4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]oct-l-yl}-carbamic acid benzyl ester; 481 ) N-|4-['5-(2-cycfoprbpyf amϊno-p'yrimidin-4-yl)-4-(6-metliyl-pyridin-2-yl)- 1 H-imidazol-
2-yl]-bicyclo[2.2.2]oct-l-yl}-acetamide;
482) N-{4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-
2-yl]-bicyclo[2.2.2]oct-l-yl}-methanesulfonamide;
483) N-{4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-
2-yl]-bicyclo[2.2.2]oct-l-yl}-2,2,2-trifluoro-acetamide;
484) 4-[5-quinoxalin-6-yl-4-(2-trifluoromethyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
485) 4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
486) 6-[2-tert-butyl-5-(2-cyclopropyl-pyrimidm-4-yl)-3H-imidazol-4-yl]-quinoxaline;
487) 6-[5-(2-byclopropyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline;
488) {4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanol;
489) 6-[5-(2-trifluoromethyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline; 490) 6-[2-tert-butyl-5-(2-trifluoroniethyl-pyrimidm-4-yl)-3H-imidazol-4-yl]-quinoxaline; 491) 4-[5-quinoxalin-6-yl-4-(2-trifluoromethyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
492) 4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
493) 6-[5-(2-cyclopropyl-pyrimidin-4-yl)-2-(l-methanesulfonyl-piperidm-4-yl)-3H-imidazol-
4-yl] -quinoxaline;
494) 445.(2-methyl-pyrimidin-4-yl)-4-[l,2,4]triazolo[4,3-a]pyridm-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
495) 4.[4.(2-methyl-ρyrimidin-4-yl)-5-[l,254]triazolo[l,5-a]ρyridine-6-yl-lH-irnidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid amide;
496) 4-[4-(2-methyl-pyrirriidiri-4-yl)-5-[l,2,4]triazolo[l,5-a]pyridine-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid;
497) 4-[4-(2-methyl-pyrimidm-4-yl)-5-[l,2,4]triazolo[l,5-a]pyridine-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
498) 4-[4-(2-metb.yl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexanol,
499) 4-[4-(2-methyl-pyrimidm-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol,
500) 4-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-2-methyl-pyrimidine,
500a) 6-[3-(2-methyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine,
502) 6- [3 -(2-methyl-pyrimidin-4-yl)- 1 H-pyrazol-4-yl] -quinoxaline,
502a) 6-[3-(2-trifluoromethyl-pyrimidm-4-yl)-lH-pyrazol-4-yl]-quinoxaline,
503) 6-[3-(2-cyclopropyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-quinoxaline,
504) 4-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-2-trifluoromethyl-pyriniidine,
505) 7-[3-(2-trifluoromethyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine, or
506) 6-[3-(2-Trifluoromethyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-qumoline.
21. The method of claim 13, wherein the inhibitor is administered locally.
22. The method of claim 13, wherein the inhibitor is administered via an implantable device.
23. The method of claim 22, wherein the device is a delivery pump.
24. The method of claim 22, wherein the device is a stent.
25. An implantable device comprising an inhibitor of TGFb type I receptor or Alk4.
26. The device of claim 25, wherein the inhibitor has the structure shown in formula I:
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein
R1"1 is aryl, heteroaryl, aralkyl, or heteroaralkyl; each R!"a is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfmyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
X1-I is cycloalkyl or heterocycloalkyl; YIVis 1a bond,":C(0)-;-C(0)-O-, -O-C(O)-, -S(O)P-O-, -O-S(O)P-, -C(O)-N(Rb)-, -N(Rb)-C(O)-, -O-C(O)-N(Rb)-, -N(Rb)-C(O)-O-, -O-S(O)p-N(Rb)-, -N(Rb)- S(O)P-O-, -N(Rb)-C(O)-N(Rc)-, -N(Rb)-S(O)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb)-C(O)-, -C(O)-N(Rb)-S(O)p-N(Rc)-, -C(O)-O-S(O)p-N(Rb)-, -N(Rb)-S(O)p-N(Rc)-C(O)-, -N(Rb)-S(O)p-O-C(O)-, -S(O)P-N(R")-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)P-, -O-, -S-, or -(C(Rb)(Rc))q-, wherein each of Rb and Rc is independently hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; p is 1 or 2; and q is 1-4;
R1"2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl; each of A1"1 and A1"2, independently, is O, S, N, or NRb, provided that at least one of A M and A 1^ iS N; and m is 0, 1, 2, or 3, provided that when m >2, two adjacent Rμa groups can optionally together to form a 4- to 8-membered optionally substituted cyclic moiety.
27. The device of claim 25, wherein the inhibitor has the structure shown in formula II:
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein each OfXn
-1, Xn
-2, Xn
-3, and Xπ-
4 is independently CR
X or N, provided that no more than two of Xn
-1, Xn
-2, Xn
-3, and Xn
-4 can be N simultaneously; each OfYn
-1 and Yn
-2 is independently CR
y or N, provided that at least one OfYn
-1 and Yn
-2 must be N; each R
11"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfϊnyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyL sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycϊo
'alkylsϋl
'Fanyl, aryl
'faryroxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; each R
11"2 is independently alkyl, alkenyl, alkynyl, acyl, halo, hydroxy, -NH
2, - NH(alkyl), -N(alkyl)
2, -NH(cycloalkyl), -N(alkyl)(cycloalkyl), -NH(heterocycloalkyl), - NH(heteroaryl), -NH-alkyl-heterocycloalkyl, -NH-alkyl-heteroaryl, -NH(aralkyl), cycloalkyl, (cycloalkyl)alkyl, aryl, aralkyl, aroyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heteroaryl, heteroaralkyl, heteroaroyl, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto
^ alkoxy, cycloalkyloxy, cycloalkyl-alkoxy, aryloxy, arylalkoxy, heterocycloalkyloxy, (heterocycloalkyl)alkoxy, heteroaryloxy, heteroarylalkoxy, alkylsulfanyl, cycloalkylsixlfanyl, (cycloalkyl)alkylsulfanyl, arylsulfanyl, aralkylsulfanyl, heterocycloalkylsulfanyl, (heterocycloalkyl)alkylsulfanyl, heteroarylsulfanyl, heteroarylalkylsulfanyl, alkylsulfmyl, alkylsulfonyl, aminocarbonyl, aminosulfonyl, alkylcarbonylamino, cycloalkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalkytycarbonylamino, (heterocycloalkytyalkylcarbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino, alkoxycarbonylaminoalkylamino, (heteroaryl)arylcarbonylaminoalkylammo, heteroaralkylcarbonylaminoalkylamino, (heteroary^arylsulfonylaminoalkylcarbonylaminoalkylamino, arylsulfonylaminoalkyl amino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, or carbamoyl; m is 0, 1, 2, 3, or 4, and when m >2, two adjacent R
1 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; n is 0, 1, 2, or 3, and when n ≥2, two adjacent R
2 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; and each of R
x and R
y is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, cycloalkylcarbonyl, (cycloalkyl)alkylcarboaiyl, aroyl, aralkylcarbonyl, heterocycloalkylcarbonyl, (heterocycloalkyl)acyl, heteroaroyl, (heteroaryl)acyl, aminocarbonyl, alkylcarbonylamino, (amino)aminocarbonyl, alkylsulfonylaminocarbonyl, alkylsulfonylamino, cycloalkylcarbonylamino, cycloalkylsulfonylamino, (cycloalkyl)alkylcarbonylamino, (cycloaUcyl)alkylsulfonylamino, arylcarbonylamino, arylsulfonylamino, aralkylcarbonylamino, aralkylsulfonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkyl)sulfonylamino, (heterocycloalkyl)alkylcarbonylamino, (heterocycloalkyl)alkylsulfonylamino, heteroarylcarbonylamino, heteroarylsulfonylamino, heteroaralkylcarbonylamino, heteroaralkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfarnoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, (cycloalkyl)alkyl, (cycloaϊkyl)alkoxy, (cycloalkyl)alkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, (heterocycloalkyl)alkyl, (heterocycloalkyl)alkoxy, (heterocycloalkyl)alkylsulfanyl, aryl, aryloxy, arylsulfanyl, aralkyl, aralkyloxy, aralkylsulfanyl, arylalkenyl, arylalkynyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, heteroaralkyl, (heteroaryl)alkoxy, or (heteroaryl)alkylsulfanyl.
28.. The device of claim 25, wherein the inhibitor has the structure shown in formula III
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein each of Xm-i, Xm-2, X111-3, and X11I-4 is independently CRm"x or N, provided that only two OfXiII-1, Xm-2, Xm-3, and Xm-4 can be N simultaneously; each of Ym-1 and Ym-2 is independently CRm"y or N, provided that at least one ofVnn and Ym-2 must be N; each R111"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; each R111"2 is independently alkyl, alkenyl, alkynyl, acyl, halo, hydroxy, -NH2, -NH(alkyl), -N(alkyl)2, -NH(cycloalkyl), -N(alkyl)(cyclocalkyl)5 - NH(heterocycloalkyl),
-NH(heteroaryl), -NH-alkyl-heterocycloalkyl, -NH-alkyl-heteroaryl, -NH(aralkyl), cycloalkyl, (cycloalkyl)alkyl, aryl, aralkyl, aroyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heteroaryl, heteroaralkyl, heteroaroyl, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkoxy, cycloalkyloxy, (cycloalkyl)alkoxy, aryloxy, arylalkoxy, hetlπfcyclόallyloxy!," '(heterocycloalkyl)alk:oxy, heteroaryloxy, heteroarylalkoxy, alkylsulfanyl, cycloalkylsulfanyl, (cycloalkyl)alkylsulfanyl, arylsulfanyl, aralkylsulfanyl, heterocycloalkylsulfanyl, (heterocycloalkyl)alkylsulfanyl, heteroarylsulfanyl, heteroarylalkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, aminosulfonyl, alkylcarbonylamino, cycloalkylcarbonylamino, (cycloalky^alkylcarbonylamino, arylcarbonylamino, aralkylcarbonylamino , (heterocycloalkytycarbonylamino, (heterocycloalky^alkylcarbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino, alkoxycarbonylaminoalkylamino, (heteroary^arylcarbonylaminoalkylamino, heteroaralkylcarbonylaminoalkylamino, (heteroary^arylsulfonylaminoalkylcarbonylaminoalkylamino, arylsulfonylaminoalkylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, or carbamoyl; m is 0, 1, 2, 3, or 4, and when m ≥_2, two adjacent R111"1 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; n is 0, 1, 2, or 3, and when n Ξ≥2, two adjacent R111"2 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; and each of Rπi"x and Rm~y is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, cycloalkylcarbonyl, (cycloalkyl)alkylcarbonyl, aroyl, aralkylcarbonyl, heterocycloalkylcarbonyl, (heterocycloalkyl)acyl, heteroaroyl, (heteroaryl)acyl, aminocarbonyl, alkylcarbonylamino, (amino)aminocarbonyl, alkylsulfonylaminocarbonyl, alkylsulfonylamino, cycloalkylcarbonylamino, cycloalkylsulfonylamino, (cycloalkytyalkylcarbonylamino, (cycloalkyl)alkylsulfonylamino, arylcarbonylamino, arylsulfonylamino, aralkylcarbonylamino, aralkylsulfonylamino, (heterocycloalkytycarbonylamino, (heterocycloalkyl)sulfonylamino, (heterocycloalkytyalkylcarbonylamino, (rieterocycloalky^alkylsulfonylamino, heteroarylcarbonylamino, heteroarylsulfonylamino, heteroaralkylcarbonylamino, heteroaralkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, (cycloalkyl)alkyl, (cycloalkyl)alkoxy, (cycloalkyl)alkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, (heterocycloallcytyalkyl, (heterocycloalkyl)alkoxy, (heterocycloalkyl)alkylsulfanyl, aryl, aryloxy, arylsulfanyl, aralkyl, aralkyloxy, aralkylsulfanyl, arylalkenyl, arylalkynyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, heteroaralkyl, (heteroaryl)alkoxy, or (heteroaryl)alkylsulfanyl.
29. The device of claim 25, wherein the inhibitor has the structure shown in formula IV
or an N-oxide or a pharmaceutically acceptable salt thereo f, wherein each R™"8 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carh>oxy, sulfo, mercapto, alkylsulfanyl, alkylsulfmyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfon;ylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloallcylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroarylox;y, heteroarylsulfanyl, or heteroaroyl;
R™'1 is a bond, alkylene, alkenylene, alkynylene, or -(CH2)F1 -O-(CH2)r2-, wherein each of rl and r2 is independently 2 or 3;
R^"2 is cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, or a bond;
R^"3 is -C(O)-, -C(O)O-, -OC(O)-, -C(O)-N(R1^)-, -N(R1^)-C(O)-, -0-C(0)-N(RIV" b)-, -N(R1^)-C(O)-O-, -0-S(O)P-N(R^"13)-, -N(R^13)- S(O)p-0-, -N(RIV"b)-C(0)-N(RIV-c)-, -N(RIV-b)-S(0)p-N(RIV-b)-, -C(O)-N(R^)-S(O)P-, -S(O)P-N(R^)-C(O)-, -S(O)P-N(R^)-, -N(R1^)-S(OV, -N(R^'13)-, -S(O)p-, -0-, -S-, or -(C(RIV~b)(RIV-c))q-, or a bond; wherein each 0£j^iv-b 3J1(J R1V-0 jg independently hydrogen, hydroxy, alkiyl, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; and p is 1 or 2 and q is 1-4;
R^"4 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkryl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl;
Rw~5 is hydrogen, unsubstituted alkyl, halo-substituted alkyl, alkoxy, alkylsulfinyl, amino, alkenyl, alkynyl, cycloalkyl, cycloalkoxy, cycloallkylsulfinyl, heterocycloalkyl, heferδ'e'yclόalkόxy, heterocycloalkylsulfinyl, aryl, aryloxy, arylsulfϊnyl, heteroaryl, heteroaryloxy, or heteroarylsulfinyl; j^iv-6 is (i) a 5_ tø 6-niembered heterocyclyl containing 1-3 hetero ring atoms selected from the group consisting of -O-, -S-, -N=, and -NR1^-, wherein Rw'd is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, tieteroaryl, or hetero aralkyl; said heterocyclyl being substituted with R^"6 and optionally substituted with one to two R1^; wherein R™"6 is oxo, thioxo, alkoxy, alkylsulfmyl, -NH2, -NH(unsubstituted alkyl), or -N(unsubstituted alkyl)2, and R1^ is alkyl, alkenyl, alkynyl, alkoxy, acyU halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mexcapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; or
(2) a fused ring heteroaryl selected from the group consisting of:
wherein ring A is an aromatic ring containing 0-4 hetero ring atoms and ring B is a 5- to 7- membered aromatic or nonaromatic ring containing 0-4 hetero ring atoms, provided that at least one of ring A and ring B contains one or more hetero ring atoms; ring A' is an aromatic ring containing 0-4 hetero ring atoms and ring B' is a 5- to 7-membered saturated or unsaturated ring containing 0-4 hetero ring atoms, provided that at least one of ring A' and ring B' contains one or more hetero ring atoms; each hetero ring atom is -O-, -S—
s -N=, or - NR^
"8-; each X
1 is independently N or C; each X
2 is independently -O- -S-, -N=, -NR
1^- , or -CHR^
"11-; where R
IV"8 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, axalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroaralkyl; each of R
1^
"11 and R^
"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcaPbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycldklkyT, cycroalfeyToxy7cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; and n is 0-2; and m is 0-3, and when m ≥2, two adjacent R
w'a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; provided that if R^
"6 is 2-naphthyridinyl, 4-quinolinyl, imidazo[l,2-a]pyridyl, or benzimidazolyl, then -R^-R^-R^-R™
"4 is not H, unsubstituted alkyl, -CH
2-C(O)-N(H)-alkyl, -CH
2-C(O)-N(alkyl)
2, or benzyl.
30. The device of claim 25, wherein the inhibitor has the structure shown in formula V
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein
Rv"! is heteroaryl; each Rv~\ independently, is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
Xv is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or a bond;
Yv is a bond, -C(O)-, -C(O)-O-, -O-C(O)-, -S(O)P-O-, -O-S(O)P-, -C(O)-N(Rb)-, -N(Rb)-C(O)-, -O-C(O)-N(Rb)-, -N(Rb)-C(O)-O-, -C(O)-N(Rb)-O-, -O-N(Rb)-C(O)-, -O-S(O)p-N(Rb)-, -N(Rb)- S(O)p-O-, -S(O)p-N(Rb)-O-, -O-N(Rb)-S(O)p-, -N(Rb)-C(O)-N(Rc)-, -N(Rb)-S(0)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb)-C(O)-, -C(O)-N(Rb)-S(O)p-N(Rc)-, -C(0)-σ-S(6%4ll&bj-; -N(RD)'-Si:O)' p-N(Rc)-C(O)-, -N(Rb)-S(O)p-0-C<O)-, -S(O)p-N(Rb)-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)p-, -O-, -S-, or -(C(Rb)(Rc))q-, wherein each of Rb and Rc, independently, is hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; p is 1 or 2 and q is 1-4;
Rv"2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocyclo alkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl; each of A , v- "i and A , V- "2 , independently, is N or NR ; and m is 0, 1, 2, or 3, and when m >2, two adjacent R v"a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety, provided that if Xv is a bond, then Yv is a bond; Rv"2 is hydrogen or alkyl; m is 1, 2, or 3; and at least one Rv'a is substituted at the 2-pyrimidinyl position.
31. The device of claim 25, wherein the inhibitor has the structure shown in formula VI:
or an N-oxide or a pharmaceutically acceptable salt thereof, wherein each RVI"a, independently, is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, - NH2, -NH(unsubstituted alkyl), -N(unsubstituted alkyl)2, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfϊnyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylarnino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; ,.Jf Vi-I j™ a bond, alkylene, alkenylene, alkynylene, or -(CH2)rl-O-(CH2)r2-, where each of rl and r2, independently, is 2 or 3;
RVI"2 is cycloalkylene, heterocycloalkylene, cyclo alkenylene, heterocycloalkenylene, arylene, heteroarylene, or a bond;
RVI"3 is -C(O)-, -C(O)-O-, -0-C(O)-, -S(O)p-O-, -O-S(O)P-, -C(0)-N(Rb)-, -N(Rb)-C(O)-, -0-C(0)-N(Rb)-, -N(Rb)-C(0)-0-, -C(0)-N(Rb)-0-, -0-N(Rb)-C(0)-, -0-S(0)p-N(Rb)-,
-N(Rb)- S(O)p-O-, -S(0)p-N(Rb)-0-, -O-N(Rb)-S(O)p-, -N(Rb)-C(0)-N(Rc)-, -N(Rb)-S(0)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb)-C(O)-, -C(0)-N(Rb)-S(0)p-N(Rc)-, -C(O)-O-S(O)p-N(Rb)-, -N(Rb)-S(0)p-N(Rc)-C(0)-3 -N(Rb)-S(O)p-O-C(O)-, -S(O)p-NCRb)-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)p-, -0-, -S-, -(C(Rb)(Rc))q-, or a bond; wherein each of Rb and Rc is independently hydrogen, hydroxy, alkyl, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; and p is 1 or 2 and q is 1-4;
RVI"4 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, heterocyclo alkenyl, (heterocycloalkenyl)alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl;
RVI"5 is hydrogen, unsubstituted alkyl, halo-substituted alkyl, alkoxy, alkylsulfϊnyl, amino, alkenyl, alkynyl, cycloalkoxy, cycloalkylsulfinyl, heterocycloalkoxy, heterocycloalkylsulfinyl, aryloxy, arylsulfinyl, heteroaryloxy, or heteroarylsulfinyl;
RVI"6 is a 5- to 6-membered monocyclic heterocyclyl or a 8- to 11-membered tricyclic heteroaryl; each being optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; and m is 0-3, and when m ≥2, two adjacent R VI"a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety.
32. The device of claim 25, wherein the inhibitor is
1) 4-(4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl)-piperidine-l- carboxylic acid benzyl ester; 2) l4'-(4'-βenzotϊ3TSϊoxol-5-yl-5-pyndin-2-yl-lH-imidazol-2-yl)-piperi acid benzyl ester;
3) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
4) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-pyrrolidine-l- carboxylic acid benzyl ester;
5) 2-(5-Benzo[l,3]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-6-methyl-pyridine; 6) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidme-l-carboxylic acid benzyl ester;
7) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidme-l- carboxylic acid benzyl ester;
8) 3 - [4-Benzo [ 1 ,3 ]dioxol- 5 -yl-5-(6-methyl-pyridin-2-yl)- 1 H-imidazol-2-yl] -pyrrolidine- 1 - carboxylic acid benzyl ester; 9) 2-(5-Benzo[l,3]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-6-methyl-pyridine;
10) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl]-6-methyl-pyridine;
11) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl]-pyridine;
12) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
13) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
14) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 2-chloro-benzyl ester;
15) 4-(4-Benzo[ 1 ,3]dioxol-5-yl-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidine- 1 -carboxylic acid 2,4-dichloro-benzylamide;
16) l-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-l-yl]- ethanone;
17) 2-[5-Benzo[ 1 ,3]dioxol-5-yl-2-(l -furan-2-yl-methyl-ρiperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
18) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-cyclohexyl}- carbamic acid benzyl ester;
19) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl] cyclohexylamine; 205Ε-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexyl}-C-ρhenyl-methanesulfonamide;
21) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
22) 4-[4-Beiizo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1 -carboxylic acid;
23) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-carbamic acid benzyl ester;
24) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-ethyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
25) 2-(5-Benzo[l,3]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-pyridine;
26) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-nitro-benzyl ester;
27) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidme-l-carboxylic acid 4,5-dimethoxy-2-nitro-benzyl ester;
28) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 3-fluoro-benzylamide;
29) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-fluoro-benzylamide;
30) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid benzylamide;
31) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(toluene-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}- pyridine;
32) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-methyl-benzylamide;
33) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-methoxy-benzylamide;
34) 4-(4-Benzo [ 1 ,3 ]dioxol-5-yl-5 -pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid 2-chloro-benzylamide;
35) 4-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-sulfonyl]- benzoic acid;
36) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid amide;
37) 4-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-sulfonyl]- benzonitrile; I 385'2^-{5-Benzo[T3]Hiox6i-5-yl-2-[l-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
39) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,4-dichloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
40) {5-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-sulfonyl]- naphthalen-l-yl}-dimethyl-amine;
41) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-4-yl-methyl)-piperidin-4-yl)]-3H-imidazol-4- yl} -pyridine;
42) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
43) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-methoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
44) l-{4-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l- sulfonylj-phenyl} -ethanone;
45) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-methyl-benzyl)-piperidin-4-yl]-3H-imidazol-4-yl}- pyridine;
46) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3-fluoro-5-trifluoromethyl-benzyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
47) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-cyclohexylmethyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
48) 2-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-l-ylmethyl]- cyclopropanecarboxylic acid ethyl ester;
49) 2-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-l-ylmetb.yl]- pyrrolidine- 1-carboxylic acid tert-butyl ester;
50) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ l-(2,2-dimethyl-[ 1 ,3]dioxolan-4-ylmethyl)-piperidin-4- yl] -3H-imidazol-4-yl} -pyridine;
51) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-ethanesulfonyl-piperidm-4-yl)-3H-imidazol-4-yl]- pyridine;
52) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(butane- 1 -sulfonyl)-piρeridin-4-yl]-3H-imidazol-4-yl} - pyridine;
53) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
54) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-phenyl-ethenesulfonyl)-piperidin-4-yl]-3H-imidazol- 4-yl} -pyridine; 55) 2-"{5-Berizdf 13 ]dioxol-5-yl-2-[ 1 -(propane- 1 -sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
56) 1 -[4-(4-Benzo [ 1 ,3]dioxol-5-yl-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidine- 1- sulfonylmethyl]-7,7-dimethyl-bicyclo[2.2.1]heptan-2-one;
57) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
58) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl} -pyridine;
59) 2-{5-Benzo[13]dioxol-5-yl-2-[l-(4-fluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
60) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,4-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl} -pyridine;
61 ) 2- {5-Benzo[ 1 ,3 ]dioxol-5-yl-2-[ 1 -(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol- 4-yl} -pyridine;
62) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-p-tolylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl] -pyridine;
63) 3-(4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l- carboxylic acid benzyl ester;
64) 3-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid benzyl ester;
65) 4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
66) 2- {5-Benzo[ 1,3] dioxol-5-yl-2-[ 1 -(pyridin-2-yl-methanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
67) 2- {5-Benzo[ 1 ,3] dioxol-5-yl-2-[ 1 -(2-naphthalen- 1 -yl-ethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
68) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-3-yl)-3H-imidazol-4- yl]-pyridine;
69) 3-[4-Benzo[l,3]dioxol-5-yl-l-b.ydroxy-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
70) 2- {5-Benzo[ 1 ,3] dioxol-5-yl-2-[ 1 -(pyridin-4-yl-methanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
71) 2- {5-Benzo[ 1 ,3] dioxol-5-yl-2-[ 1 -(pyridin-3-yl-methanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine; 72) 2~'{5-Berizόp'3]diόxό'I-5-yl-2- [ 1 -(3-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4- yl]-3H-imidazol-4-yl} -pyridine;
73) 3-[4-Benzo[l,3]dioxol-5-yl-l-h.ydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- pyrrolidine- 1-carboxylic acid benzyl ester;
74) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2- [ 1 -(4-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4- yl]-3H-imidazol-4-yl} -pyridine;
75) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2- [ 1 -(3,5-bis-trifluoromethyl-phenylmethanesulfonyl)- piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
76) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(biphenyl-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
77) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl} -pyridine;
78) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(pyridin-2-yl-methanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
79) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-phenoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
80) 2-{5-Benzo[l,3]dioxol-5-yl-2-[ l-(biphenyl-4-ylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
81) 4-[5-Benzo[l,3]dioxol-5-yl-l-rnethyl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine- 1-carboxylic acid benzyl ester;
82) 4-[4-Benzo[l,3]dioxol-5-yl-l-methyl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine- 1-carboxylic acid benzyl ester;
83) {4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylj-carbamic acid benzyl ester;
84) 2-{5-Benzo[l,3]dioxol-5-yl-2-[ l-(3-phenoxy-phenylmethanesulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
85) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-ethanesulfonyl-ρiρeridin-4-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
86) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(propane-1 -sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
87) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(butane- 1 -sulfonyl)-ρiperidin-4-yl]-3H-imidazol-4-yl} - 6-methyl-pyridine;
88) 2-{5-Benzo[l,3]dioxol-5-yl-2-[ l-(pyridin-3-ylmethanesulfonyl)-ρiperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
imidazol-4-yl} -6-methyl-pyridine;
90) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-difluoro-phen^ylmethanesulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
91) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3-trifluoromethyl-ρlienylmethanesulfonyl)-piperidin-4- yl] -3H-imidazol-4-yl} -6-methyl-pyridine;
92) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(tliiophene-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
93) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(butane-l-sulfonyO-piperidin-3-yl]-3H-imidazol-4-yl}-
6-methyl-pyridine;
94) 2-[5-Benzo[l ,3]dioxol-5-yl-2-(l -phenylmethanesulfbnyl-piperidin-3-yl)-3H-imidazol-4- yl] -6-methyl-pyridine;
95) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(l-methyl-lH-imidazole-4-sulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
96) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(5-methyl-isoxazole-4-sulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
97) 4-[5-Benzo[l,3]dioxol-5-yl-l-hydroxy-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
98) Butane- 1 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-cyclohexyl}-amide;
99) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexyl}-C-pyridin-2-yl-methanesulfonamide;
100) Thiophene-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-cyclohexyl}-amide;
101) 1 -Methyl- lH-imidazole-4-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl- pyridin-2-yl)-lH-imidazol-2-yl]-cyclohexyl}-amide;
102) 4-[4-Benzo[l ,3]dioxol-5-yl- 1 -hydroxy-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
103) 4-[4-Benzo[ 1 ,3]dioxol-5-yl- 1 -hydroxy-5-(6-methyl-pyridin-2-yl)- lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
104) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-bromo-pyridin-2-yl)-lH-imidazol-2-yl]-ρiperidine-l- carboxylic acid benzyl ester;
105) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(thiophene-3-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine; 106) '"!'- {5-Benzό[T,3]dioxol-5-yl-2-[ 1 -(5-methyl-2-trifluoromethyl-f\iran-3-sulfonyl)- piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
107) 4-[2-(l-phenylmethanesulfonyl-piperidin-4-yl)-5-(6-methyl-pyridin-2-yl)-lH-imidazol- 4-yl] -pyridin-2-yl- fluoride;
108) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-trifluoromethyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
109) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-bromo-pyridin-2-yl)-l-hydrox3^-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
110) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-pipericiin-4-yl)-3H-imidazol-4- yl] -6-bromo-pyridine;
111) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imicaazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanol;
112) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
113) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-2H-imidazol-2-yl]-piperidine-l- sulfonic acid dimethylamide;
114) l-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-irnidazol-2-yl]-piperidin-
1 -yl} -3 -phenyl-propan- 1 -one;
115) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(propane-2-sulfonyl)-piperidirx-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
116) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2] octane- 1 -carbonitrile;
117) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-ylamine;
118) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-metliyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-C-phenyl-methanesulfonamide;
119) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2] oct- 1 -yl} -methanesulfonamide;
120) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-C-pyridin-2-yl-methanesulfonamide;
121) 2-{5-Benzo[l,3]dioxol-5-yl-2-[4-(lH-tetrazol-5-yl)-bicyclo[2.2.2]oct-l-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
122) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetamide;
acid (4-[4-beiizo [ 1 ,3 ]dioxol-5 -yl-5 -(6-methyl-pyridin-2-yl)- 1 H- imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl} -amide;
124) l-Methyl-lH-imidazole-4-sulfbnic acid {4-[4-benzo[ 1,3] dioxol-5 -yl-5 -(6-methyl- pyridin-2-yl)-lH-imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl}-amide;
125) Thiophene-3 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl}-amide;
126) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[l -(2-phenyl-emenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
127) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
128) Methanesulfonic acid 4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]oct-l-ylmethyl ester;
129) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetonitrile;
130) {4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetic acid;
131) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2] oct- 1 -ylmethyl} -methanesulfonamide;
132) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(biphenyl-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
133) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-phenoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl}-6-methyl-pyridine;
134) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,4-dichloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
135) N- {4-[4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-ylmethyl}-C-phenyl-methanesulfonamide;
136) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct- 1 -ylmethyl} -C-pyridin-2-yl-methanesulfonamide;
137) 4-[4_Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid benzylamide;
138) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (pyridin-2-ylmethyl)-amide;
139) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid 3-chloro-4-fluoro-benzylamide; 14O) 4-[4-Benzott,'3]aioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (furan-2-ylmethyl)-amide;
141) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfonyl-ρyrrolidin-3-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
142) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(butane- 1 -sulfonyl)-pyrrolidin-3-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
143) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(l-methyl-lH-imidazole-4-sulfonyl)-pyrrolidin-3-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
144) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-pyrrolidin-3-yl)-3H-imidazol-
4-yl] -6-methyl-pyridine;
145) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloro-benzenesulfonyl)-pyrrolidin-3-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
146) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
147) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(2-naphthalen-2-yl-ethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl}-6-methyl-pyridine;
148) l-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine- 1 -sulfonylmethyl} -7,7-dimethyl-bicyclo[2.2.1 ]heptan-2-one;
149) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
150) 4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridm-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methylamide;
151) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid ethylamide;
152) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid butylamide;
153) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid isopropylamide; 154) 4.[4-Benzo[l53]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (3-imidazol-l-yl-propyl)-amide; 155) 2-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine- 1 -sulfonylmethyl} -phenylamine;
156) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (l-methyl-5-methylsulfanyl-lH-[l,2,4]triazol-3-yl)- amide; 15I{7) "4'-[l-Be'nzot r';3iaioxδl-5-yl-5-(6-methyl-pyridin-2-yl)- 1 H-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid cyclohexylamide;
158) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazoi-2-yl]- bicyclo[2.2.2]oct- 1 -yl} -pyrrolidin- 1 -yl-methanone;
159) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid dimethylamide;
160) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid diethylamide;
161) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid dipropylamide;
162) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (5,7-difluoro-benzothiazol-2-yl)-aniide; 163) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid benzothiazol-2-ylamide; 164) 4-[4-Benzo[l:,3]dioxol-5-yl-5-(6-meth.yl-pyridm-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid (lH-benzoimidazol-2-yl)-amide; 165) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (2 -hydroxy- l-methyl-2-phenyl-etlxyl)-amide; 166) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid (pyridin-4-ylmethyl)-amide;
167) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin-l- yl}-(3-chloro-phenyl)-methanone;
168) {4-[4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)- lH-imidazol-2-yl]-piperidin- 1 - yl} -(4-fluoro-phenyl)-methanone;
169) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin-l- yl } -(4-methoxy-phenyl)-methanone;
170) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-cyclopropyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid;
171) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methoxy-amide;
172) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid hydroxyamide;
173) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl}-carbamic acid benzyl ester; l^^'-^-Benzotr^ϊdioxoβ-yl-S-Cό-methyl-pyridin-l-y^-lH-imidazol^-yl]- bicyclo[2.2.2]octane-l-carboxylic acid hydrazide;
175) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl} -acetamide;
176) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethylj-methanesulfonamide;
177) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl}-C-phenyl-methanesulfonamide;
178) Butane- 1 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl] -cyclohexylmethyl} -amide;
179) Propane-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-cyclohexylmethyl} -amide;
180) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl}-C-pyridin-2-yl-methanesulfonamide;
181) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl}-C-pyridin-4-yl-methanesulfonamide;
182) (4-Methoxy-benzyl)-{4-[5-(6-methyl-pyridin-2-yl)-2-(l-phenylmethanesulfonyl- piperidin-4-yl)-lH-imidazol-4-yl]-pyridin-2-yl}-amine;
183) 4-[5-(6-Methyl-pyridin-2-yl)-4-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl- lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
184) 4-[5-(6-Methyl-pyridin-2-yl)-4-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
185) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl- lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
186) 4-[4-(6-Methyl-pyridin-2-yl)-5-[ 1 ,2,4]triazolo[ 1 ,5-a]ρyridin-6-yl- lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
187) 4-[4-(6-Methyl-pyridin-2-yl)-5-[l ,2,4]triazolo[l ,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
188) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane- 1 -carboxylic acid;
189) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-2,2,2-trifluoro-acetamide;
190) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol; 1 ø'ϊ )1!4-[i4-t6-Cycloprbpyl-'pyridin-2-yl)-5-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl- 1 H-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
192) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
193) N-{4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-sulfamide;
194) Sulfamic acid 4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl ester;
195) {4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl} - carbamic acid benzyl ester;
196) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carbonyl}-methanesulfonamide;
197) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carbonyl}-benzenesulfonamide;
198) 4-[5-(3-Metriyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH:- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester; 199) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid;
200) N-{4-[4-(6-Methyl-pyridm-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl}- acetamide;
201) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl- lH-imidazol-2-yl]-bicyclo[2.2.2]octane- 1-carboxylic acid methyl ester;
202) 4- [4-(6-Methyl-pyridin-2-yl)-5-qumoxalin-6-yl- 1 H-imidazol-2-yl] -bicyclo[2.2.2 ] octane- 1-carboxylic acid;
203) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane- 1-carboxylic acid hydroxyamide;
204) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane- 1-carboxylic acid amide;
205) N-{4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl}- methanesulfonamide;
206) 2,2,2-Trifluoro-N- {4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl- 1 H-imidazol-2-yl] - eye lohexyl} -acetamide;
207) 4-[4-(5-Fluoro-6-methyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-irriidazol- 2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester; 20S)lt4-t2-[T-(Bufane-l-sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)- lH-imidazol-4- yl]-pyridin-2-yl}-(4-methoxy-benzyl)-amine;
209) 4-[2-[l-(Butane-l-sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)-l H-imidazol-4- yl]-pyridin-2-ylamine;
210) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl]-6-ethyl-pyridine;
211) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridirx-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
212) 4- [5-(3 -Methyl-4-oxo-3 ,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridirx-2-yl)- 1 H- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
213) N-{4-[5-(6-Methyl-pyridin-2-yl)-4-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanesulfonamide;
214) N-{4-[5-(6-Methyl-ρyridin-2-yl)-4-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetamide.
215) 4-[2-(6-Methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyridin-3-yl]-pyrimidin-2-ylamine;
216) 4-(2-pyridin-2-yl-pyrazolo[l,5-a]pyridin-3-yl)-pyrimidin-2-ylamine;
217) 4- [2-(6-methyl-pyridin-2-yl)-pyrazolo [1,5 -a]pyridin-3 -yl] -pyrimidin-2-ylamine;
218) 2-(6-methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-pyrazolo [ 1 ,5-a]pyridine;
219) 4-[2-(6-chloro-pyridin-2-yl)-pyrazolo[l,5-c]pyrimidin-3-yl]-pyrimidin-2-ylamine;
220) 2-(6-methyl-pyridm-2-yl)-3-(2-moφholin-4-yl-pyrimidin-4-yl)-pyrazolo[l,5- c]pyrimidine;
221 ) 4- [2-(6-methyl-pyridin-2-yl)-pyrazolo [ 1 , 5 -a]pyrazin-3 -yl] -pyrimidin-2-ylamine; 222) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyrimidin-3-yl]-pyrimidin-2-ylamine; 223) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-c]pyrimidin-3-yl]-pyrimidin-2-ylamine; 224) (2-Methoxy-ethyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
225) (3-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin.-2-ylamino}- proρyl)-carbamic acid tert-butyl ester;
226) (3-Imidazol-l-yl-propyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
227) (4-Methoxy-benzyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridiiι-3-yl]- pyrimidin-2-yl} -amine;
228) [2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridin-
6-yl]-methanol; 22'9)"3'-(2:Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- ajpyridine;
230) (4- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - butyl)-carbamic acid tert-butyl ester;
231) (4-Amino-benzyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} - amine;
232) (5- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - pentyl)-carbamic acid tert-butyl ester;
233) [3-(2-Amirio-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-6-yl]- methanol;
234) [3-(2-ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-7-yl]- methanol;
235) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(2-morpholin-4-yl-ethyl)-amine;
236) [3-(2-Amirio-pyrirnidin-4-yl)-6-methyl-2-(6-rn.ethyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(2-pyridin-2-yl-ethyl)-amine;
237) [3 -(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-irnidazo [ 1 ,2- a]pyridin-8-yl]-(2-pyridin-3-yl-ethyl)-amine;
238) [3-(2-methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-irnidazo[ 1 ,2- a]pyridin-6-yl] -methanol ;
239) [3-(2-Amin.o-pyrirnidin-4-yl)-6-niethyl-2-(6-methyl-pyridin-2-yl)-irnidazo[l,2- a]pyridin-8-yl]-(2-pyridin-4-yl-ethyl)-amine;
240) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(3-morpholin-4-yl-propyl)-amine;
241 ) [3-(4-Methyl-piperazin- 1 -yl)-propyl]- {4-[2-(6-methyl-pyridin-2-yl)-imidazo [1,2- a]pyridin-3 -yl] -p yrimidin-2-yl} -amine;
244) [3-(4-Methyl-piperidin-l-yl)-propyl]- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2- a]pyridin-3 -yl] -p yrimidin-2-yl} -amine;
245) [4-(2-Pyridin-2-yl-imidazo[ 1 ,2-a]pyridm-3-yl)-pyrimidin-2-yl]-pyridin-3-yhnethyl- amine;
246) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-((R)-l- phenyl-ethyl)-amine;
247) {4- [2-(6-Methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridin-3 -yl]-pyrimidin-2-yl} -((S)- 1 - phenyl-ethyl)-amine; 241B)14-I2-(&-M'eayl-pyπdin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(lH- tetrazol-5-yl)-amine;
249) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-yl} -(2H- pyrazol-3-yl)-amine;
250) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2- morpholin-4-yl-ethyl)-amine;
251) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2-pyridin- 2-yl-ethyl)-amine;
252) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2-pyridin- 3-yl-ethyl)-amine;
253) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-yl} -(2-pyridin- 4-yl-ethyl)-amine;
254) {4-[2-(6-Methyl-ρyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(3- morpholin-4-yl-propyl)-amine;
255) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(3- piperidin- 1 -yl-propyl)-amine;
256) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- [1,3 ,4]thiadiazol-2-yl-amine;
257) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridine; 258) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridine- 6-carboxylic acid methyl ester;
259) 2-(6-Methyl-pyridin-2-yl)-3-(2-metliylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridine- 7-carboxylic acid ethyl ester;
260) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[ 1 ,2- a]pyrimidin-7-ylamine;
261) {7,7-Dimethyl-8-[5-(4-{4-[2-(6-methyl-ρyridin-2-yl)-imidazo[l,2-a]ρyridin-3-yl]- pyrimidin-2-ylamino} -butylcarbamoyl)-p entyl]-2-oxo-4-trifluoromethyl-7, 8-dihydro-2H- 1 - oxa-8-aza-anthracen-5-yl} -methanesulfonic acid;
262) 2-(2,7-Difluoro-6-hydroxy-3-oxo-9,9a-dihydro-3H-xanthen-9-yl)-3,5,6-trifluoro-4-[(4- {4-[2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidm-2-ylamino}- butylcarbarnoyl)-methylsulfanyl] -benzoic acid;
263) -(6-Methyl-pyridin-2-yl)-3-(2-moφholin-4-yl-pyrirnidin-4-yl)-imidazo[l,2-a]pyridine; 264) 2-(6-Methyl-pyridm-2-yl)-3-(2-piperidin-l-yl-pyrimidin-4-yl)-imidazo[l,2-a]pyridine; 265) 2-(6-Methyl-pyridin-2-yl)-3-(2-pyrrolidin- 1 -yl-pyrimidin-4-yl)-imidazo[ 1 ,2-a]pyridine; 2δ'6Jir2-(6-MetEyϊ-pyridin-2-yl)-3-[2-(lH-^ a]pyridine;
267) 2-(6-Methyl-pyridin-2-yl)-3 -pyrimidin-4-yl-imidazo [ 1 ,2-a]pyridine;
268) 2-(6-Methyl-pyridin-2-yl)-3-pyrimidin-4-yl-imidazo[l,2-a]pyrimidm-7-ylamine;
269) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-8- ylamine;
270) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyτidin-2-yl)-imidazo[l,2-a]pyridine-6- carbonitrile;
271) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyτidin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid;
272) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyτidin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide;
273) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide;
274) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyτidin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid (2-dimethylamino-ethyl)-amide;
275) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid (2-methoxy-ethyl)-amide;
276) 3-(2-Ainino-pyrimidm-4-yl)-2-(6-methyl-pyτidin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid (2-thiophen-2-yl-ethyl)-amide;
277) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyτidin-2-yl)-irriidazo[l,2-a]pyridirLe-6- carboxylic acid [3-(4-methyl-piperazin-l-yl)-propyl]-amide;
278) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid amide;
279) 3 -(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyτidin-2-yl)-imidazo [ 1 ,2-a]pyridine-6- carboxylic acid cyclopropylamide;
280) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyτidin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid ethylamide;
281) 3-(2-Amino-pyrimidm-4-yl)-2-(6-methyl-pyxidin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid hydroxyamide;
282) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyτidm-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid methoxy-amide;
283) 3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyτidin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid methyl ester; 284)'f3-(2-Amin6-pynήiidϊri-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]p^ carboxylic acid;
285) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]p3αidine-7- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide;
286) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-7- carboxylic acid (2-amino-ethyl)-amide;
287) 3-(2-Aniino-pyrimidin-4-yl)-2-(6-metliyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-7- carboxylic acid (2-dimethylamino-ethyl)-amide;
288) 3-(2-Aniino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (2-hydroxy-ethyl)-amide;
289) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (2-oxo-2-pyridin-3-yl-ethyl)-amide;
290) 3-(2-Arnino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]p3τidme-7- carboxylic acid (2-thiophen-2-yl-ethyl)-amide;
291) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (piperidin-3-ylmethyl)-amide;
292) 3-(2-Amino-pyrimidin-4-yl)-2-(6-rnethyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid 2,2-dimethylhydrazide;
293) 3-(2-Amino-pyrimidin-4-yl)-2-(6-rnethyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid amide;
294) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid cyclopropylamide;
295) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[ 1 ,2-a]pyridine-7- carboxylic acid ethyl ester;
296) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-7- carboxylic acid ethylamide;
297) 3 -(2- Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridine-7- carboxylic acid hydroxyamide;
298) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-7- carboxylic acid methoxy-amide;
299) 3 -(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyrimidin-7- ylamine;
300) 3-(2-Azetidm-l-yl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-irnidazo[l,2-a]pyridine;
301) 3 -(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a] pyridine-7-carboxylic acid ethyl ester; 302)'3'K2-MetHane'sulfonyl-pyπmidin-4-yl)-2-(6-methyl-pyridin-2- a]pyridine-6-carboxylic acid methyl ester;
303) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-7-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2- a] pyridine;
304) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-8-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2- a] pyridine;
305) 3,3-Dimethyl-N-[2-(6-methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)- imidazo[l,2-a]pyrimidin-7-yl]-butyramide;
306) 3 -(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [1,2- a]pyridine-6-carbonitrile;
307) 3 -(2-Methylsulfanyl-pyrimidin-4-yl)-2-pyridin-2-yl-imidazo [ 1 ,2-a]pyridine;
308) 3 ,6-Dichloro-N-(4- {4- [2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridin-3 -yl]- pyrimidin-2-ylamino}-butyl)-2-(2,4,5,7-Tetrachloro-6-hydroxy-3-oxo-9,9a-dihydro-3H- xanthen-9-yl)-terephthalamic acid;
309) 3 - [2-(2-Methyl-aziridin- 1 -yl)-pyrimidin-4-yl]-2-(6-methyl-pyridin-2-yl)-im.idazo[ 1 ,2- a] pyridine;
310) 3-[2-(4-Methyl-piperazin-l-yl)-pyrimidin-4-yl]-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a] pyridine;
311) 3-{[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carbonyl] -amino} -propionic acid methyl ester;
312) 3 - { [3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridine-7- carbonyl]-amino} -propionic acid methyl ester;
313) 3- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - phenol;
314) 4-(2- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- - ethyl)-benzenesulfonamide;
315) 4-(2-Pyridin-2-yl-imidazo[l,2-a]pyridin-3-yl)-pyrimidin-2-ylamine; 316) 4-[2-(6-Chloro-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamine;
317) 4-[2-(6-Methyl-pyridin-2-yl)-7-trifluoromethyl-imidazo[ 1 ,2-a]pyridm-3-yl]-pyrimidiiL-
2-yl-amine;
318) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrirnidin-2-ylamine;
319) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l52-a]pyridin-3-yl]-pyrimidine-2-carbonitrile;
320) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridm-3-yl]-pyrimidine-2-carboxylic acid amide; 32T) H-[6-6rbnϊ6-2K'6-met!Kyl-pyridm-2-yl)-imidazo[ 1 ,2-a]pyridm-3-yl]-pyrimidin-2- ylamine; 322) 4-[6-Chloro-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
323) 4-[6-Fluoro-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
324) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-morpholm-4-yl-ethylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidin-2-ol;
325) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-2-yl-eth.ylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidin-2-ol;
326) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-3-yl-etfcιylamino)-imidazo[ 1 ,2-a] pyridin-3 -yl] -pyrimidin-2-ol;
327) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-4-yl-etfcιylaiΗino)-imidazo[l,2-a] pyridin-3 -yl] -pyrimidin-2-ol;
328) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-morpholin-4-yl-inαidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ol;
329) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-morpholin-4-yl-iinidazo[ 1 ,2-a]pyridin-3-yl]- pyrimidin-2-ylaniine;
330) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
331) 4-[7-Aminomethyl-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a.]pyridin-3-yl]-pyrimidin-2- yl-amine;
332) 4-[7-Methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
333) 4-[8-Benzyloxy-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ol;
334) 4-[8-Benzyloxy-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl- amine;
335) 4-[8-Bromo-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l=(2-a]pyridm-3-yl]-pyrimidin-
2-ol;
336) 4-[8-Methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
337) 6-Chloro-3-(2-methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[ 1 ,2- a] pyridine;
338) 5-Dimethylammo-naphthalene-l-sulfonic acid (4-{4-[2-(6-rnethyl-pyridin-2-yl)- imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}-butyl)-amide; 3f9|"6-(2';7-b1ifϊuorδl-6-hydroxy-3-oxo-3H-xanthen-9-yl)-N-(4-{4-[2-(6- imidazo[ 1 ,2-a]pyridin-3 -yl] -pyrimidin-2-ylamino } -butyl)-isophthalamic acid; 340) 6-Amino-9-[2-carboxy-5-(4-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ylamino}-butylcarbamoyl)-phenyl]-xanthen-3-ylidene-animonium;
341) 6-Bromo-2-(6-methyl-ρyridin-2-yl)-3 -(2-methylsulfanyl-pyrimidin-4-yl)-imidazo [ 1 ,2-a] pyridine;
342) 6-Fluoro-2-(6-methyl-pyridin-2-yl)-3-(2-metliylsulfanyl-pyrimidin-4-yl)-inαidazo[l,2-a] pyridine;
343) 7-Amino-4-methyl-3-[(4- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyricϊin-3-yl]- pyrimidin-2-ylamino } -butylcarbamoyl)-methyl] -2-oxo-2H-chromene-6-sulfonic acid;
344) Cyclobutyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl3-pyrimidin-2-yl} - amine;
345) Cyclopentyl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- yl} -amine;
346) Cyclopropyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2- yl} -amine;
347) Cyclopropyl-methyl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
348) Dimethyl-{4-[2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrinxidin-2-yl}- amine;
349) Isopropyl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyriirLidin-2-yl'}- amine;
350) Methyl- {4- [2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridin-3-yl] -pyrimidin-2-yl} - amine;
350a) N-(2-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamino} -ethyl)-acetamide;
351) N-(4-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidm-2-ylamino}- butyl)-acetamide;
352) N,N-Dimethyl-N'-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-y'l]-pyrirnidin-
2-yl}-ethane-l,2-diamine;
353) N-[2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a] pyrimidin-7-yl]-3-pyridin-3-yl-propionamide;
354) N-[2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazc»[l,2-a] pyrimidin-7-yl] -nicotinamide; 355)Η-[2-(6-MethyI-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a] pyrimidin-7-yl]-propionamide;
356) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carbonyl]-methanesulfonamide;
357) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-metliyl-pyridin-2-yl)-iinidazo[l,2-a]pyridine-7- carbonyl] -methanesulfonamide;
358) N- [3 -(2-Amino-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyrimidin-7- yl] -2-(3 -methoxy-phenyl)-acetamide;
359) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6--methyl-pyridin-2-yl)-irnidazo[l,2-a]pyrimidiri-7- yl]-3 ,3 -dimethyl-butyr amide;
360) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidin-7- yl]-3-pyridin-3-yl-propionamide;
361) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidiri-7- yl]-acetamide;
362) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidiri-7- yl] -nicotinamide;
363) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7-yl]-2-(3-methoxy-phenyl)-acetamide;
364) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7-yl]-3,3-dimethyl-butyramide;
365) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7-yl]-3-pyridm-3-yl-propionamide;
366) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7-yl] -nicotinamide;
367) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7-yl]-propionamide;
368) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-metliyl-pyridm-2-yl)-imidazo[l,2-a]pyriniidia-7- yl] -propionamide;
369) N-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- acetamide;
370) Nl-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-butane-
1,4-diamine;
371) Nl - {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-yl} - propane- 1 ,3 -diamine; 372)11'N-(4-{4>-[2-('6-MfetHyl-pyπdm-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- butyl)-(BODIPY FL) amide; and
373) N-(4- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - butyl)-(Texas Red-X) amide
374) N-[3-(2-amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyrimidin-7- yl]-acetamide;
375) N-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- acetamide.
376) 3-(3-pyridm-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propylaniine,
377) N-[3-(3-pyridin-2-yl-4-qumolin-4-yl-pyrazol-l-yl)-propyl]-acetamide,
378) N-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol- 1 -yl)-propyl]-methanesulfonamide,
379) dimethyl-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propyl]-amine, 380) 4-{3-pyridin-2-yl-l-[2-(lH-tetrazol-5-yl)-ethyl]-lH-pyrazol-4-yl}-quinoline, 381) 4-[3 -pyridin-2-yl- 1 -(3-pyrrolidin- 1 -yl-propyl)- 1 H-pyrazol-4-yl] -quinoline,
382) 5 -(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-pyridin-2-ylamine,
383) 2,4-dimethoxy-5-(3 -pyridin-2-yl- lH-pyrazol-4-yl)-pyrimidine,
384) 3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propionic acid, 385) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indole, 386) 2-[4-(2,3-dihydro-benzo[l,4]dioxin-6-yl)-lH-pyrazol-3-yl]-pyridine, 387) N-hydroxy-3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propionamide, 388) 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-ethylamine,
389) N-[2-(3 -pyridin-2-yl-4-quinolin-4-yl-pyrazol- 1 -yl)-ethyl] -methanesulfonamide,
390) 2-methyl-4-methylsulfanyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyrimidine,
391) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-pyridine,
392) 2-[4-(2,3-dihydro-benzofuran-5-yl)- lH-pyrazol-3-yl] -pyridine,
393) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[d]isoxazole,
394) 3-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-propionitrile, 395) N-{3-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-propyl}- methanesulfonamide,
396) 2-[4-(2,3-dihydro-benzo[l,4]dioxin-6-yl)-lH-pyrazol-3-yl]-6-metliyl-pyridme, 397) [4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridm-2-yl)-pyrazol-l-yl]-acetonitrile, 398) N-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethyl}- methanesulfonamide,
399) 4-[3-(6-methyl-pyridin-2-yl)- 1 H-pyrazol-4-yl] -2-methylsulfanyl-pyrimidine,
400) 4-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-2H-ρhthalazm- 1 -one,
402) 6-(3-pyridin-2-yl- lH-pyrazol-4-yl)-[l ,2,4]triazolo[ 1 ,5-a]pyridine,
403) 3-methyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
404) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-4H-berizo[l,4]oxazm-3-one,
405) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinoxaline,
406) 3-(4-nitro-benzyl)-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
407) 5-methyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]pyridine,
408) 4-methyl-7-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-3 ,4-dihydro- 1 H-benzo [e] [ 1 ,4]diazepine- 2,5-dione,
409) 2,3-dimethyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one, 410) 6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l:,5-a]pyridine,
410a) 1 -methoxy-4-(3 -pyridin-2-yl- lH-pyrazol-4-yl)-isoquinoline, 411) 2-methyl-6-(3-pyridm-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]pyridine, 41 Ia) 4-(3 -pyridin-2-yl- lH-pyrazol-4-yl)-2H-isoquinolin-l -one,
412) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-trifluoromethyl-pyridine, 412a) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-vinyl-pyridine,
413) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-propenyl-pyridine, 414) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-ethyl-pyridine,
415) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-propyl-pyridine,
416) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-cyclopropyl-pyridine,
417) l-[6-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-pyridin-2-yl]-etlianol,
418) 4-methoxy-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline,
419) 6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-quinoline,
420) 6-(3-pyridin-2-yl- lH-pyrazol-4-yl)-qumazolin-4-ylamine,
421 ) 6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-3H-quinazolin-4-one,
422) 7-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyrido[l,2-a]pyrimidin-4-oixe,
423) 6-[3-(6-cyclopropyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine,
424) 3-methyl-6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3H-quinazolin-4-one, 425) 4-(2-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethoxy}- ethoxy)-bicyclo[2.2.2]octane-l-carboxylic acid,
426) 4-(2-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethoxy}- ethoxy)-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester, 427) 4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l -yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester,
428) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-isopropyl-pyridine, 429)i|'2-(4-benzδ[riS7dϊoxbl-5-yl-5-trifluoromethyl-lH-pyrazol-3-yl)-6-bromo-pyridine, 430) 6-[3-(5-fluoro-6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine;,
431) 6-[3-(6-trifluoromethyl-ρyridin-2-yl)-lH-pyrazol-4-yl]-[l ,2,4]triazolo[l ,5-a]pyridine.,
432) 6-[3-(6-methyl-pyridin-2-yl)- 1 H-pyrazol-4-yl]-quinoxaline,
432a) 6-[3-(6-cyclopropyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3-methyl-3H-qumazolin-4-one,
433) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l ,2,4]triazolo[l ,5-b]pyridazine, 433 a) 6-[3 -(6-methyl-pyridin-2-yl)- lH-pyrazol-4-yl] -quinoline,
434) 6-(4-benzo[l ,3 ]dioxol-5-yl-lH-pyrazol-3-yl)-3-fluoro-2-methyl-pyridine, 435) 7 -methoxy-3 -methyl-6-(3 -pyridin-2-yl- 1 H-pyr azol-4-yl)-3H-quinazolin-4-one,
436) (4-morpholin-4-yl-phenyl)-[6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-quinazolin-4-yl] -amine,
437) 4-isopropoxy-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline, 438) 6-(3-Pyridin-2-yl- 1 H-pyrazol-4-yl)-quinolin-4-ylamine,
439) {4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohexyl}- carbamic acid benzyl ester,
440) 4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohexylamine3,
441) N-{4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohexyl}- methanesulfonamide,
442) 6-[3-(5-fluoro-6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-quinoxaline,
443) 7-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]pyridine,
444) l-tert-butyl-3-[6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolin-4-yl]-urea,
445) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[l,2,5]thiadiazole,
446) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[l,2,5]oxadiazole,
447) 5-(3-Pyridin-2-yl-lH-pyrazol-4-yl)-benzooxazole, 448) 4-morpholin-4-yl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolme, 449) 6-[3-(6-trifluoromethyl-pyridin-2-yl)-lH-pyrazol-4-yl]-quinoxaline, 450) 4-(4-methoxy-phenyl)-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline,
451) 5-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-benzo[l ,2,5]thiadiazole,
452) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzothiazole,
453) 3-(3-methoxy-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
454) 5-methyl-thiopliene-2-carboxylic acid [6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolin_-4- yl] -amide,
455) 5-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3-phenyl-benzo[c]isoxazole,
456) 3-(4-methoxy-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
457) 3-(4-chloro-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
458) 3-(4-ethyl-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole, 459) |4-methoxy-pnenyl)-[i6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoπ
460) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3-thiophen-3-yl-benzo[c]isoxazole,
461) 5-(3 -pyridin-2-yl- 1 H-pyrazol- 4-yl)- 1 H-indazole-3 -carboxylic acid,
462) 5-(3-Pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid methylamide,
463) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid dimethylamide,
464) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid (2,2-dimethyl- propyl)-amide,
465) 5 -(3 -pyridin-2-yl- lH-pyrazol-4-yl)-l H-indazole-3 -carboxylic acid phenylamide, 466) morpholin-4-yl-[5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazol-3-yl]-methanone,
467) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid benzylamide,
468) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid cyclopentylamide; 469) 4-[4-benzo[l,3]dioxol-5-yl-5-(2-methylsulfanyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- benzamide;
470) 4-[4-benzo[l,3]dioxol-5-yl-5-(2-methylsulfanyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- benzonitrile;
471) 4-[5-(2-methanesulfonyl-pyrirnidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
472) 4-[5-(2-metlioxy-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
473) 4-[5-(2-hydroxy-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
474) 4-[5-(2-cyclopropylamino-pyτimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
475) 4-[5 -(2-cyclopropylamino-pyτimidin-4-yl)-4-(6-m.ethyl-pyridin-2-yl)- lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid;
476) 4-[5-(2-cyclopropylamino-pyiimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
477) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
478) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methoxy-amide;
479) 4-[5-(2-amino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
480) {4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]oct-l-yl}-carbarnic acid benzyl ester; 48 t) N- {4-[5-'[2-cyclopropylamino-pynmidin-4-yl)-4-(6-m.ethyl-pyridm-2-yl)- 1 H-imidazol-
2-yl]-bicyclo[2.2.2]oct-l-yl}-acetamide;
482) N-{4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-iinidazol-
2-yl]-bicyclo[2.2.2]oct- 1 -yl} -methanesulfonamide;
483) N-{4-[5-(2-cyclopropylammo-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-
2-yl]-bicyclo[2.2.2]oct-l-yl}-2,2,2-trifluoro-acetamide;
484) 4-[5-quinoxalin-6-yl-4-(2-trifluoromethyl-pyrimidin-4-yl)- 1 H-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
485) 4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
486) 6-[2-tert-butyl-5-(2-cyclopropyl-pyrimidin-4-yl)-3H-ixnidazol-4-yl]-quinoxaline;
487) 6-[5-(2-byclopropyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline;
488) {4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-iniidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanol;
489) 6-[5-(2-trifluoromethyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline;
490) 6-[2-tert-butyl-5-(2-trifluoromethyl-pyrimidin-4-yl)-3Η-imidazol-4-yl]-quinoxaline; 491) 4-[5-quinoxalin-6-yl-4-(2-trifluoromethyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
492) 4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yrl-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
493) 6-[5 -(2-cyclopropyl-pyrimidin-4-yl)-2-(l -methanesulf onyl-piperidin-4-yl)-3H-imidazol-
4-yl] -quinoxaline;
494) 4-[5-(2-methyl-pyrimidin-4-yl)-4-[l,2,4]triazolo[4,3-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
495) 4-[4-(2-methyl-pyrimidin-4-yl)-5-[l,2,4]triazolo[l,5-a]pyridine-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
496) 4-[4-(2-methyl-pyrirnidin-4-yl)-5-[l,2,4]triazolo[l,5-a]pyridine-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid;
497) 4-[4-(2-methyl-pyrimidin-4-yl)-5-[l,2,4]txiazolo[l,5-a]pyridine-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
498) 4-[4-(2-methyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexanol;
499) 4-[4-(2-methyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH:-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol,
500) 4-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-2-methyl-pyrimidine,
500a) 6-[3-(2-methyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-[l ,2,4]triazolo[l ,5-a]pyridine, 50 f) &-[3-(2-ffifIύδrόmetnyl:pyrirnidin-4-yl)- 1 H-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine,
502) 6- [3 -(2-methyl-pyrimidin-4-yl)- 1 H-pyrazol-4-yl] -quinoxaline,
502a) 6-[3-(2-trifluoromethyl-ρyrimidin-4-yl)-lH-pyrazol-4-yl]-quiiioxaline,
503) 6-[3-(2-cyclopropyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-quinoxaline,
504) 4-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-2-trifluoromethyl-pyrimidine,
505) 7-[3-(2-1rifluoromethyl-pyriniidin-4-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine, or
506) 6-[3-(2-Trifluoromethyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-quinoline.
33. The device of claim 25, wherein device is a delivery pump.
34. The device of claim 25, wherein the device is a stent.
35. A method of treating or preventing restinosis, vascular disease, or hypertension by administering to a subject in need thereof a compound of the formula 1, II, III, IV, V, or VI, or an N-oxide or a pharmaceutically acceptable salt thereof, wherein the compound of formula I has the structure:
R1"1 is aryl, heteroaryl, aralkyl, or heteroaralkyl; each RI-a is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, aUcylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylstilfanyl, heterocyclo alkyl, heterocycloalkyloxy, heterocycloalkylsulfan.yl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfairyl, or heteroaroyl;
Xi-1 is cycloalkyl or heterocycloalkyl;
Y1-1 is a bond, -C(O)-, -C(O)-O-, -O-C(O)-, -S(O)P-O-, -O-S(O)P-, -C(O)- N(Rb)-, -A(kbli)-C(05-7-0-d(b)-N(Rft)-, -N(Rb)-C(O)-O-, -0-S(Op-N(R13)-, -N(Rb)- S(0)p-O-, -N(Rb)-C(O)-N(Rc)-, -N(Rb)-S(O)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(0)p-N(Rb)-C(O)-, -C(0)-N(Rb)-S(0)p-N(Rc)-, -C(O)-O-S(O)p-N(Rb)-, -N(Rb)-S(O)p-N(Rc)-C(O)-, -N(Rb)-S(O)p-O-C(O)-, -S(O)p-N(Rb)-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)P-, -C-, -S-, or -(C(Rb)(Rc))q-, wherein each of Rb and Rc is independently hydrogen, hydroxy, alk;yl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl, p is 1 ox 2, and q is 1-4;
R1"2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl; each of A1"1 and A1"2, independently, is O, S, N, or NRb, provided that at lea.st one of A w and A l'2 is N; and m is 0, 1, 2, or 3, and when m >2, two adjacent R1"8 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; the compound of formula II has the structure:
wherein each OfXn
-1, Xπ-
2, Xn-
3, and Xn
-4 is independently CR
X or N, provided that aio more than two of X
H-1, X n
-2, X
H-3, and X
U-4 can be N simultaneously; each OfYn
-1 and Y
11-2 is independently CR
y or N, provided that at least one of Yn
-1 and Yn
-2 must be N; each R
11"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamiaio, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkylorxy,
'heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; each R
11"2 is independently alkyl, alkenyl, alkynyl, acyl, halo, hydroxy, -NH
2, -NH(alkyl), -N(alkyl)
2, -NH(cycloalkyl), -NCalkylXcycloalkyl), - NH(heterocycloalkyl), -NH(heteroaryl), -NH-alkyl-heterocycloalkyl, -NH-alkyl- heteroaryl, -NH(aralkyl), cycloalkyl, (cycloalkyl) alkyl, aryl, aralkyl, aroyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heteroaryl, heteroaralkyl, heteroaroyl, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkoxy, cycloalkyloxy, cycloalkyl-alkoxy, aryloxy, arylalkoxy, heterocycloalkyloxy, (heterocycloalkyl)alkoxy, heteroaryloxy, heteroarylalkoxy, alkylsulfanyl, cycloalkylsulfanyl, (cycloalkyl)alkylsulfanyl, arylsulfanyl, aralkylsulfanyl, heterocycloalkylsulfanyl, (heterocycloalkyl)alkylsulfanyl, heteroarylsulfanyl, heteroarylalkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, aminosulfonyl, alkylcarbonylamino, cycloalkylcarbonylamino, (cycloalky^alkylcarbonylamino, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalkytycarbonylamino, (heterocycloalkytyalkylcarbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino, alkoxycarbonylammoalkylamino, (heteroaryl)arylcarbonylaminoalkylamino, heteroaralkylcarbonylaminoalkylamino, (heteroary^arylsulfonylaminoalkylcarbonylaniirioalkylamino, arylsulfonylaminoalkylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, or carbamoyl; m is 0, 1, 2, 3, or 4, and when m >2, two adjacent R
1 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; n is 0, 1, 2, or 3, and when n ≥2, two adjacent R
2 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; and each of R
x and R
y is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfmyl, alkylsulfonyl, cycloalkylcarbonyl, (cycloalky^alkylcarbonyl, aroyl, aralkylcarbonyl, heterocycloalkylcarbonyl, (heterocycloalkyl)acyl, heteroaroyl, (heteroaryl)acyl, aminocarbonyl, alkylcarbonylamino, (amino)aminocarbonyl, alkylsulfonylaminocarbonyl, alkylsulfonylamino, cycloalkylcarbonylamino, cycloalkylsulfonylamino, (cycloalky^alkylcarbonylamino, (cycloalky^alkylsulfonylamino, arylcarbonylamino, arylsulfonylamino, aralkylcarbonylamino, aralkylsulfonylamino,
(heterocycloalky^carbonylamino, (heterocycloalkyl)sulfonylamino, "(lieϊerbcy"croallcyl)alk;ylcarbonylamino, (heterocycloalkytyalkylsulfonylamino, heteroarylcarbonylamino, heteroarylsulfonylamino, heteroaralkylcarbonylamino, heteroaralkylsulfonylami.no, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, (cycloalkyl)alkyl, (cycloalkyl)alkoxy, (cycloalkyl)alkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, (heterocycloalk;yl)alkyl, (heterocycloalkyl)alkoxy, (heterocycloalkyl)alkylsulfanyl, aryl-, aryloxy, arylsulfanyl, aralkyl, aralkyloxy, aralkylsulfanyl, arylalkenyl, arylalkynyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, heteroaralkyl, (heteroaryl)alk:oxy, or (heteroaryl)alkylsulfanyl; the compound of formula III has the structure:
wherein each of Xπn, Xm-2, Xπi-3, and Xra-4 is independently CRπi'x or N, provided that no more than two OfXm-1, Xπi-2, X111-3, and Xm-4 can be N simultaneously; each of Ym-i and Y1n-2 is independently CRiπ"y or N, provided that at least one OfYm-1 and Ym-2 must be N; each R111"1 is independently alkyl, alkenyl, alkynyl, alkozxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; each R111"2 is independently alkyl, alkenyl, alkynyl, acyU halo, hydroxy, -NH2, -NH(alkyl), -N(alkyl)2, -NH(cycloalkyl), -N(alkyl)(cyclocalkyl), - TSJH(heterocycIdalkyl), -lSIH(heteroaryl), -NH-alkyl-heterocycloalkyl, -NH-alkyl- heteroaryl, -NH(aralkyl), cycloalkyl, (cycloalkyl)alkyl, aryl, aralkyl, aroyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heteroaryl, heteroaralkyl, heteroaroyl, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkoxy, cycloalkyloxy, (cycloalkyl)alkoxy, aryloxy, arylalkoxy, heterocycloalkyloxy, (heterocycloalkyl)alkoxy, heteroaryloxy, heteroarylalkoxy, alkylsulfanyl, cycloalkylsulfanyl, (cycloalkyl)alkylsulfanyl, arylsulfanyl, aralkylsulfanyl, heterocycloalkylsulfanyl, (heterocycloalkyl)alkylsulfanyl, heteroarylsulfanyl, heteroarylalkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, aminosulfonyl, alkylcarbonylamino, cycloalkylcarbonylamino, (cycloalky^alkylcarbonylamino, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalkytycarbonylamino, (heterocycloalkytyalkylcarbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino, alkoxycarbonylaminoalkylamino, (heteroaryl)arylcarbonylaminoalkylamino, heteroaralkylcarbonylaminoalkylamino, (heteroary^arylsulfonylaminoalkylcarbonylaminoalkylamino, arylsulfonylaminoalkylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, or carbamoyl; m is 0, 1, 2, 3, or 4, and when m ≥2, two adjacent R111'1 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; n is 0, 1, 2, or 3, and when n Ξ≥2, two adjacent R111"2 groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; and each of Rm"x and Rπi"y is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, cycloalkylcarbonyl, (cycloalkytyalkylcarbonyl, aroyl, aralkylcarbonyl, heterocycloalkylcarbonyl, (heterocycloalkyl)acyl, heteroaroyl, (heteroaryl)acyl, aminocarbonyl, alkylcarbonylamino, (amino)aminocarbonyl, alkylsulfonylaminocarbonyl, alkylsulfonylamino, cycloalkylcarbonylamino, cycloalkylsulfonylamino, (cycloalkytyalkylcarbonylamino, (cycloalkytyalkylsulfonylamino, arylcarbonylamino, arylsulfonylamino, aralkylcarbonylamino, aralkylsulfonylamino, (heterocycloalkytycarbonylamino, (heterocycloalkyl)sulfonylamino, (heterocycloalky^alkylcarbonylamino, (heterocycloalkytyalkylsulfonylamino, heteroarylcarbonylamino, heteroarylsulfonylamino, heteroaralkylcarbonylamino, heteroaralkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, (cycloallcyϊ) aϊkyl, (cycloalkyl)alkoxy, (cycloalkyl)alkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, (heterocycloalkyl)alkyl, (heterocycloalkyl)alkoxy, (heterocycloalkyl)alkylsulfanyl, aryl, aryloxy, arylsulfanyl, aralkyl, aralkyloxy, aralkylsulfanyl, arylalkenyl, arylalkynyl, heteroaryl, heteroaryloxy, hetero arylsulfanyl, heteroaralkyl, (heteroaryl)alkoxy, or (heteroaryl)alkylsulfanyl; the compound of formula IV has the structure:
wherein each R™"* is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
R1^"1 is a bond, alkylene, alkenylene, alkynylene, or -(CH2)rl-O-(CH2)r2-, where each of rl and r2 is independently 2 or 3;
R^"2 is cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, or a bond;
RIV-3 is -C(O)-, -C(O)O-, -OC(O)-, -C(0)-N(RIV-b)-, -N(RIV"b)-C(0)-, -O- C(O)-N(R1^)-, -N(R1^)-C(O)-O-, -O-S(O)p-N(RIV-b)-, -N(R1^)- S(0)p-0-, -N(RIV" b)-C(0)-N(RIV-c)-, -N(RIV-b)-S(0)p-N(RIV"b)-, -C(O)-N(RIV"b)-S(O)p-, -S(0)p-N(RIV'b)- " Cf(O)-; -S(O)p-N(Rlv-b)-, -N(RIV-b)-S(O)p-, -N(R1^)-, -S(O)P-, -O-, -S-, or - (C(RIV"b)(RIV'c))q-, or a bond; wherein each of Rw'h and Rw'c is independently hydrogen, hydroxy, alkyl, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; p is 1 or 2; and q is 1-4;
Rw~4 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alk:yl, heterocycloalkyl, (heterocycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl;
Rw~5 is hydrogen, unsubstituted alkyl, halo-substituted alkyl, alkoxy., alkylsulfinyl, amino, alkenyl, alkynyl, cycloalkyl, cycloalkoxy, cycloalkylsulfmyl, heterocycloalkyl, heterocycloalkoxy, heterocycloalkylsulfinyl, aryl, aryloxy, arylsulfinyl, heteroaryl, heteroaryloxy, or heteroarylsulfinyl;
R^" is (1) a 5- to 6-membered heterocyclyl containing 1-3 hetero ring atoms selected from the group consisting of -O-, -S-, -N=, and -NR^"0-, where JZ.w~d is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroaralkyl; said heterocyclyl being substituted with R^"6 and optionally substituted with one to two Rw"f; where Rw'e is oxo, thioxo, alkoxy, alkylsulfmyl, -NH2, -NH(unsubstituted alkyl), or -N(unsubstituted a.lkyl)2, and R^ is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulflnyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocyclo alkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; or
(2) a fused ring heteroaryl selected from the group consisting of:
wherein ring A is an aromatic ring containing 0-4 hetero ring atoms, and ring B is a 5- to 7-membered aromatic or nonaromatic ring containing 0-4 hetero ring atoms, provided that at least one of ring A and ring B contains one or more hetero ring atoms; ring A' is an aromatic ring containing 0-4 hetero ring atoms, and ring B' is a 5- to 7-membered saturated or unsaturated ring containing 0-4 hetero ring atoms, provided that at least one of ring A' and ring B' contains one or more hetero ring atoms; each hetero ring atom is -O-, -S-, -N=, or -NR
IV"g-; each X
1 is independently N or C; each X
2 is independently -O- -S-, -N=, -NR
IV'g- or -CHR™
" h-; where R
w'e is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroaralkyl; each of R
w'h and R^
"1 is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; and n is 0-2; and m is 0-3, and when m >2, two adjacent R
w'& groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety; provided that if R^
"6 is 2-naphthyridinyl, 4-quinolinyl, imidazo[l,2-a]pyridyl, or benzimidazolyl, then -R^-R^-R^-R™
"4 is not H, unsubstituted alkyl, -CH
2-C(O)-N(H)-alkyl, -CH
2-C(O)-N(alkyl)
2, or benzyl; the compound of formula V has the structure
wherein
R >v- "i is heteroaryl; each Rv"a, independently, is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfϊnyl, alkylsulfonyl, aminocarbonyl, aiKyicaroonyiammo, aryicar-Dυπylamino, heteroarylcarbonylami.no, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
Xv is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or a bond;
Yv is a bond, -C(O)-. -C(O)-O-, -O-C(O)-, -S(O)P-O-, -O-S(O)P-, -C(O)-N(Rb)-, -N(Rb)-C(O)-, -O-C(O)-N(Rb)-, -N(Rb)-C(O)-O-, -C(0)-N(Rb)-0-, -O- N(Rb)-C(O)-, -0-S(OVN(R13)-, -N(Rb)- S(O)P-O-, -S(O)p-N(Rb)-O-, -O-N(Rb)-S(O)p-, -N(Rb)-C(O)-N(R>, -N(Rb)-S(O)p-N(Rc)-, -C(O)-N(Rb)-S(O)p-, -S(O)p-N(Rb)-C(O)-, -C(O)-N(Rb)-S(O)p-N(RcK -C(O)-O-S(O)p-N(Rb)-, -N(Rb)-S(O)p-N(Rc)-C(O)-, -N(Rb)-S(O)p-O-C(O)-, -S(O)p-N(Rb)-, -N(Rb)-S(O)p-, -N(Rb)-, -S(O)P-, -O-, -S-, or -(C(Rb)(Rc))q-, wherein eacli of Rb and Rc, independently, is hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl, p is 1 or 2, and q is 1-4;
Rv"2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl; each of Av"! and Av"2, independently, is N or NRb; and m is O, 1, 2, or 3, and when m >2, two adjacent R v"a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety, provided that if Xv is a bond, then Yv is a bond; Rv"2 is hydrogen or alkyl; m is 1, 2, or 3; and at least one Rv"a is substituted at the 2-pyrimidinyl position; and the compound of formula VI has trie structure: RV VIl--3>3__p RVN I-4
wherein each RVI"a, independently, is alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, -NH2, -NH(unsubstituted alkyl), -N(unsubstituted alkyl)2, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, heterocycloalkylcarbonyl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
RVM is a bond, alkylene, alkenylene, alkynylene, or -(CH2)rl-O-(CH2)r2-, where each of rl and r2, independently, is 2 or 3;
RVI"2 is cycloalkylene, heterocycloalkylene, cyclo alkenylene, heterocycloalkenylene, arylene, heteroarylene, or a bond;
R
VI"3 is -C(O)-, -C(O)-O-, -O-C(O)-, -S(O)p-O-, -O-S(O)
P-, -C(0)-N(R
b)-, -N(R
b)-C(0>, -0-C(0)-N(R
b)-, -N(R
b)-C(0)-0-, -C(O)-N(R
b)-O-, -0-N(R
b)-C(0)-, -O-S(O)
p-N(R
b)-, -N(R
b)- S(O)
p-O-, -S(O)
p-N(R
b)-O-, -O-N(R
b)-S(O)
p-, -N(R
b)-C(0)-N(R
c)-, -N(R
b)-S(0)p-N(R
c)-, -C(O)-N(R
b)-S(O)
p-, -S(O)
p-N(R
b)-C(O)-,
-N(R
b)-S(O)
p-O-C(O)-, -S(O)
p-N(R
b>, -N(R
b)-S(O)
p-, -N(R
b)-, -S(OV, -0-, -S-, -(C(R
b)(R
c))
q-, or a bond; wherein each of R
b and R
c is independently hydrogen, hydroxy, alkyl, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl, p is 1 or 2, and q is 1-4;
''K
VIJ4'is
"iiydrogeή, alkyϊ, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl;
RVI"5 is hydrogen, unsubstituted alkyl, halo-substituted alkyl, alkoxy, alkylsulfinyl, amino, alkenyl, alkynyl, cycloalkoxy, cycloalkylsulfinyl, heterocyclo alkoxy, heterocycloalkylsulfinyl, aryloxy, arylsulfήryl, heteroaryloxy, or heteroarylsulfϊnyl;
RVI"6 is a 5- to 6-membered monocyclic heterocyclyl or a 8- to 11-membered bicyclic heteroaryl; each being optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, gixanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylammo, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cyclo alkylsulfanyl, heterocycloalkyl, heterocyclo alkyloxy, heterocycloalkylsulfanyl, cycloalkylcarbonyl, heterocycloalkylcarbonyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; and m is 0-3, and when m Ξ≥2, two adjacent R VI"a groups can optionally join together to form a 4- to 8-membered optionally substituted cyclic moiety.
36. The method of claim 35, wherein restenosis is coronary restenosis, peripheral restenosis, carotid restenosis.
37. The method of claim 35, wherein vascular disease is intimal thickening, vascular remodeling, or organ transplant-related vascular disease.
38. The method of claim 37, wherein the vascular disease is intimal thickening or vascular remodeling.
39. The method of claim 35, wherein hypertension is primary or secondary hypertension, systolic hypertension, pulmonary hypertension or hypertension-induced vascular remodeling.
40. The method of claim 35, wherein the compound is l) 4-(4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl)-piperidine-l- carboxylic acid benzyl ester; 2) 4-(4-Benzo[ 1 ,3]dioxoI-5-yl-5-pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxyΗc acid benzyl ester;
3) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin.e-l- carboxylic acid benzyl ester;
4) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-pyrrolidine-l- carboxylic acid benzyl ester;
5) 2-(5-Benzo[l,3]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-6-methyl-pyridine; 6) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carbox>/lic acid benzyl ester;
7) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidirLe-l- carboxylic acid benzyl ester;
8) 3-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-pyrrolidixie-l- carboxylic acid benzyl ester;
9) 2-(5-Benzo[l,3]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-6-methyl-pyridine; 10) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-4-yl)-3H-imid-azol-4- yl] -6-methyl-pyridine;
11) 2-[5-Benzo[ 1 ,3]dioxol-5-yl-2-(l -phenylmethanesulfonyl-piperidin-4-yl)-3H-iinid-azol-4- yl] -pyridine;
12) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
13) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
14) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridm-2-yl-lH-imidazol-2-yl)-piperidine-l-carbo^cylic acid 2-chloro-benzyl ester;
15) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carbo^iylic acid 2,4-dichloro-benzylamide;
16) 1 -[4-(4-Benzo[ 1 ,33dioxol-5-yl-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidin- 1-yl]- ethanone;
17) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-furan-2-yl-methyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
18) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-cyclotiexyl}- carbamic acid benzyl ester;
19) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl] cyclohexylamine; 20) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylJ-C-phenyl-methanesulfonamide;
21) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
22) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
23) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-carbamic acid benzyl ester;
24) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-ethyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
25) 2-(5-Benzo[ 1 ,3]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-pyridine;
26) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-nitro-benzyl ester;
27) 4-(4-Benzo[ 1 ,3]dioxol-5-yl-5-pyridin-2-yl- 1 H-imidazol-2-yl)-piperidine- 1 -carboxylic acid 4,5-dimethoxy-2-nitro-benzyl ester;
28) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 3-fluoro-benzylamide;
29) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-fluoro-benzylamide;
30) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid benzylamide;
31) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(toluene-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}- pyridine;
32) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 4-methyl-benzylamide;
33) 4-(4-Benzo[ 1 ,3]dioxol-5-yl-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidine- 1-carboxylic acid 4-methoxy-benzylamide;
34) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid 2-chloro-benzylamide;
35) 4-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-sulfonyl]- benzoic acid;
36) 4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxylic acid amide;
37) 4-[4-(4-Benzo[ 1 ,3]dioxol-5-yl-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidine- 1 -sulfonyl]- benzonitrile; 38)'t2-T5-Benzo[I,3]dioxoT-5-yl-2-[l-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
39) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,4-dichloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
40) {5-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-sulfonyl]- naphthalen- 1 -yl} -dimethyl-amine;
41) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-4-yl-methyl)-piperidin-4-yl)]-3H-imidazol-4- yl} -pyridine;
42) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l -(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
43) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-methoxy-benzenesulfonyl)-pipeτidin-4-yl]-3H- imidazol-4-yl} -pyridine;
44) l-{4-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l- sulfonyl] -phenyl} -ethanone;
45) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-methyl-benzyl)-piperidin-4-yl]-3H-imidazol-4-yl}- pyridine;
46) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3-fluoro-5-trifluoromethyl-benzyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
47) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-cycloliexylmethyl-piperidm-4-yl)-3H-imidazol-4-yl]- pyridine;
48) 2-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-l-ylmethyl]- cyclopropanecarboxylic acid ethyl ester;
49) 2-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidin-l-ylmethyl]- pyrrolidine- 1-carboxylic acid tert-butyl ester;
50) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[l -(2,2-dimethyl-[ 1 ,3]dioxolan-4-ylrriethyl)-piperidin-4- yl] -3H-imidazol-4-yl} -pyridine;
51) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-ethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]- pyridine;
52) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(butane- 1 -sulfbnyl)-piperidin-4-yl] -3H-imidazol-4-yl} - pyridine;
53) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
54) 2- (5-Benzo[l ,3]dioxol-5-yl-2-[l-(2-phenyl-ethenesulfonyl)-piperidin-4-yl]-3H-imidazol- 4-yl} -pyridine; 55 j 2-X5-'feenzo['ϊ 31$^ yl} -pyridine;
56) l-[4-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l- sulfonylmethyl]-7,7-dimethyl-bicyclo[2.2.1]heptan-2-one;
57) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
58) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl} -pyridine;
59) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(4-fluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
60) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,4-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl} -pyridine;
61) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H-imιidazol- 4-yl} -pyridine;
62) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-p-tolylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl] -pyridine;
63) 3-(4-Benzo[ 1 ,3]dioxol-5-yl-l -hydroxy-5-pyridin-2-yl- lH-imidazol-2-yl)-piperidio.e- 1 - carboxylic acid benzyl ester;
64) 3-(4-Benzo[l,3]dioxol-5-yl-5-pyridin-2-yl-lH-imidazol-2-yl)-piperidine-l-carboxiylic acid benzyl ester;
65) 4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-vl]- piperidine-1 -carboxylic acid benzyl ester;
66) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(pyridin-2-yl-methanesulfonyl)-piperidin-4-yl] -3 H- imidazol-4-yl} -pyridine;
67) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-naphthalen-l-yl-ethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
68) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-3-yl)-3H-imidazol-4- yl]-pyridine;
69) 3-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1 -carboxylic acid benzyl ester;
70) 2- {5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-4-yl-methanesulfonyl)-ρiperidin-4-yl]-3 H- irnidazol-4-yl} -pyridine;
71) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(pyridin-3-yl-methanesulfonyl)-ρiρeridin-4-yl] -3 H- imidazol-4-yl} -pyridine; 72J'2-'{5-Benzo[l,3]diόxor-5-yl-2-[l-(3-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4- yl]-3H-imidazol-4-yl}-pyridine;
73) 3-[4-Benzo[l ,3]dioxol-5-yl-l -hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- pyrrolidine-1-carboxylic acid benzyl ester;
74) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(4-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4- yl]-3H-imidazol-4-yl} -pyridine;
75) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-bis-trifluorometliyl-phenylmethanesulfonyl)- piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
76) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(biphenyl-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -pyridine;
77) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl} -pyridine;
78) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-2-yl-methanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
79) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-phenoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
80) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(biphenyl-4-ylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -pyridine;
81) 4-[5-Benzo[l,3]dioxol-5-yl-l-methyl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
82) 4-[4-Benzo[l,3]dioxol-5-yl-l-methyl-5-(6-metliyl-pyridin-2-yl)-lH-irnidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
83) {4-[4-Benzo[ 1 ,3]dioxol-5-yl- 1 -hydroxy-5-(6-methyl-ρyridin-2-yl)- lH-imidazol-2-yl]- cyclohexylj-carbamic acid benzyl ester;
84) 2- {5 -Benzo [1,3] dioxol-5 -yl-2- [ 1 -(3 -phenoxy-phenylmethanesulfonyl)-piperidin-4-yl] - 3H-imidazol-4-yl}-6-methyl-pyridine;
85) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-ethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
86) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(propane-l-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
87) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(butane- 1 -sulfonyl)-ρiρeridin-4-yl]-3H-imidazol-4-yl} - 6-methyl-pyridine;
88) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l-(pyridin-3-ylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine; 89)"2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(pyridin-4-ylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
90) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
91) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(3-trifluoromethyl'phenylmethanesulfonyl)-piperidin-4- yl]-3H4midazol-4-yl}-6-methyl-pyridine;
92) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(thiophene-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl } -6-methyl-pyridine;
93) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(butane-1 -sulfonyl)-piρeridin-3-yl]-3H-imidazol-4-yl} - 6-methyl-pyridine;
94) 2-[5-Benzo[ 1 ,3]dioxol-5-yl-2-(l -phenylmemanesulfonyl-piperidin-3-yl)-3H-imidazol-4- yl] -6-methyl-pyridine;
95) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(l-methyl-lH-imidazole-4-sulfonyl)-piperidin-4-yl]- 3H-imidazol-4-yl}-6-methyl-pyridine;
96) 2- {5-Benzo[l ,3]dioxol-5-yl-2-[l -(5-methyl-isoxazole-4-sulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
97) 4-[5-Benzo[l,3]dioxol-5-yl-l-hydroxy-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
98) Butane-1 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)~lH- imidazol-2-yl] -cyclohexyl} -amide;
99) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- cyclohexyl}-C-pyridin-2-yl-methanesulfonamide;
100) Thiophene-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH- imidazol-2-yl] -cyclohexyl} -amide;
101) 1 -Methyl- lH-imidazole-4-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl- pyridin-2-yl)-lH-imidazol-2-yl]-cyclohexyl}-amide;
102) 4-[4-Benzo[ 1 ,3]dioxol-5-yl- l-hydroxy-5-(6-methyl-pyridin-2-yl)- lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
103) 4-[4-Benzo[l,3]dioxol-5-yl-l-hydroxy-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
104) 4-[4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-bromo-pyridin-2-yl)- lH-imidazol-2-yl]-piperidine- 1 - carboxylic acid benzyl ester;
105) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(thiophene-3-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine; 106) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(5-methyl-2-trifluoromethyl-furan-3-sulfonyl)- piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
107) 4-[2-( 1 -phenylmethanesulfonyl-piperidin-4-yl)-5-(6-methyl-pyridin-2-yl)-lH-imidazol- 4-yl]-pyridin-2-yl-fluoride;
108) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-trifluoromethyl-pyridin-2-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
109) 4-[5-Benzo[ 1 ,3]dioxol-5-yl-4-(6-bromo-pyridin-2-yl)- 1 -hydroxy- lH-imidazol-2-yl] - piperidine- 1-carboxylic acid benzyl ester;
110) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl] -6-bromo-ρyridine;
111) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanol;
112) 4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
113) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-2H-imidazol-2-yl]-piperidine-l- sulfonic acid dimethylamide;
114) l-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidm-
1 -yl} -3 -prienyl-propan- 1 -one;
115) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-meth.yl-pyridine;
116) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carbonitrile;
117) 4_[4_Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridm-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-ylamine;
118) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-C-phenyl-methanesulfonamide;
119) N-{4-[4-Benzo[l53]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanesulfonamide;
120) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-C-pyridin-2-yl-methanesulfonamide;
121) 2-{5-Benzo[l,3]dioxol-5-yl-2-[4-(lH-tetrazol-5-yl)-bicyclo[2.2.2]oct-l-yl]-3H- imidazol-4-yl}-6-methyl-ρyridine;
122) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetamide;
imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl}-amide;
124) 1 -Methyl- lH-imϊdazole-4-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl- pyridin-2-yl)-lH-imidazol-2-yl]-bicyclo[2.2.2]oct-l-yl}-amide;
125) Thiophene-3-sulfbnic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl] -bicyclo [2.2.2] oct- 1 -yl} -amide;
126) 2-{5-Benzo[l,3]ciioxol-5-yl-2-[l-(2-phenyl-ethenesulfonyl)-piperidm-4-yl]-3H- imidazol-4-yl} -6-meth.yl-pyridine;
127) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-phenyl-ethanesulfonyl)-ρiperidin-4-yl]-3H- imidazol-4-yl}-6-methyl-pyridine;
128) Methanesulfonic acid 4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl] -bicyclo [2.2.2] oct- 1 -ylmethyl ester;
129) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl }-acetonitrile;
130) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl} -acetic acid;
131) N-{4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-iniidazol-2-yl]- bicyclo[2.2.2]oct-l-ylmethyl}-methanesulfonamide;
132) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(biphenyl-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4- yl} -6-methyl-pyridine ;
133) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-phenoxy-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-mettιyl-pyridine;
134) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(3,4-dichloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-meth.yl-pyridine;
135) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-iniidazol-2-yl]- bicyclo[2.2.2]oct-l-ylmetb.yl}-C-phenyl-methanesulfonamide;
136) N- {4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo [2.2.2] oct- 1 -ylmethyl} -C-pyridin-2-yl-methanesulfonamide; 137) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid benzylamide;
138) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid (pyridin-2-ylmethyl)-amide; 139) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane- 1 -carboxylic acid 3-chloro-4-fluoro-benzylamide; 140) 4-[4-Benzo[l,3Jdioxol-5-yl-5-(6-metliyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (furan-2-ylmethyl)-amide;
141) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-methanesulfonyl-pyrrolidin-3-yl)-3H-imidazol-4-yl]-6- methyl-pyridine;
142) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(butane- l-sulfonyl)-ρyrrolidin-3-yl]-3H-imidazol-4- yl} -6-methyl-pyridine;
143) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(l-methyl-lH-imidazole-4-sulfonyl)-pyrrolidin-3-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
144) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenybΩ.ethanesulfonyl-pyrrolidin-3-yl)-3H-imidazol-
4-yl]-6-methyl-pyridine;
145) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(4-chloro-benzenesulfonyl)-pyrrolidin-3-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
146) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
147) 2-{5-Benzo[l,3]dioxol-5-yl-2-[l-(2-naphthalen-2-yl-ethanesulfonyl)-piperidin-4-yl]-
3H-imidazol-4-yl}-6-methyl-pyridine;
148) l-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine- l-sulfonylmethyl}-7,7-dimethyl-bicyclo[2.2.1]lieptan-2-one;
149) 2- {5-Benzo[ 1 ,3]dioxol-5-yl-2-[ 1 -(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H- imidazol-4-yl} -6-methyl-pyridine;
150) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methylamide;
151) 4-[4_Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid ethylamide;
152) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid butylamide;
153) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid isopropylamide; 154) 4-[4_Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (3-imidazol-l-yl-propyl)-amide; 155) 2-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidine- 1 -sulfonylmethyl} -phenylamine;
156) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (l-meth.yl-5-methylsulfanyl-lH-[l,2,4]triazol-3-yl)- amide;
2O8 157) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH:-iniidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid cyclohexylamide;
158) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-pyrrolidin-l-yl-methanone;
159) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH:-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid dimethylamide;
160) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH:-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid diethylamide;
161) 4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid dipropylamide;
162) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid (5,7-difluoro-benzothiazol-2-yl)-amide;
163) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH:-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid benzothiazol-2-ylamide;
164) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH:-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (lH-benzoimidazol-2-yl)-amide;
165) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH:-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid (2-hydroxy-l -methyl-2-phenyl-ethyl)-amide;
166) 4-[4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)- lEC-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid (pyridin-4-ylmethyl)-arnide;
167) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]-piperidin-l- yl}-(3-chloro-phenyl)-methanone;
168) {4-[4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-l H-imidazol-2-yl]-piperidin- 1 - yl} -(4-fluoro-phenyl)-methanone;
169) {4-[4-Benzo[ 1 ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-l Η-imidazol-2-yl]-piperidin- 1 - yl}-(4-methoxy-phenyl)-methanone;
170) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-cyclopropyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
171) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-lH:-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methoxy-amide;
172) 4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-lH[-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
173) {4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-ρyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethylj-carbamic acid benzyl ester; 174) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid hydrazide;
175) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl} -acetamide;
176) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethylj-methanesulfonamide;
177) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethylJ-C-phenyl-methanesulfonamide;
178) Butane- 1 -sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl] -cyclohexylmethyl} -amide;
179) Propane-2-sulfonic acid {4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH- imidazol~2-yl]-cyclohexylmethyl}-atnide;
180) N- {4-[4-Benzo[l ,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl}-C-pyridin-2-yl-methanesulfonamide;
181) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- cyclohexylmethyl}-C-pyridin-4-yl-methanesulfonamide;
182) (4-Methoxy-benzyl)-{4-[5-(6-methyl-pyridm-2-yl)-2-(l-phenylniethanesulfonyl- piperidin-4-yl)-lH-imidazol-4-yl]-pyridm-2-yl}-amme;
183) 4-[5-(6-Methyl-pyridin-2-yl)-4-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-iinidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
184) 4-[5-(6-Methyl-pyridm-2-yl)-4-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
185) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
186) 4-[4-(6-Methyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-iinidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
187) 4-[4-(6-Methyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]ρyridin-6-yl-lH-imIdazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid amide;
188) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl- lH-imidazol-2- yl] -bicyclo [2.2.2] octane- 1 -carboxylic acid;
189) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-2,2,2-trifluoro-acetamide;
190) 4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yO- bicyclo[2.2.2]octan-l-ol; 191) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
192) 4-[4-(6-Cyclopropyl-pyridin-2-yl)-5-[l,2,4]triazolo[l,5-a]pyridin-6-yl-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
193) N-{4-[5-Benzo[l,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-sulfatnide;
194) Sulfamic acid 4-[4-benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl ester;
195) {4-[4-(6-Methyl-pyridin-2-yl)-5-qumoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl}- carbamic acid benzyl ester;
196) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carbonyl}-methanesulfonamide;
197) N-{4-[4-Benzo[l,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carbonyl}-benzenesulfonamide;
198) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester; 199) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid;
200) N- {4-[4-(6-Methyl-pyridm-2-yl)-5-quinoxalin-6-yl- lH-imidazol-2-yl]-cyclohexyl} - acetamide;
201) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane-
1-carboxylic acid methyl ester;
202) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane-
1-carboxylic acid;
203) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane-
1-carboxylic acid hydroxyamide;
204) 4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-bicyclo[2.2.2]octane-
1-carboxylic acid amide;
205) N-{4-[4-(6-Methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexyl}- methanesulfonamide;
206) 2,2,2-Trifluoro-N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- cyclohexyl} -acetamide;
207) 4-[4-(5-Fluoro-6-methyl-pyridin-2-yl)-5-[ 1 ,2,4]triazolo[l ,5-a]pyridin-6-yl-lH-imidazol-
2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester; 208) {4-[2-[l-(Butane-l-sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)-lH-imidazol-4- yl] -pyridin-2-yl} -(4-methoxy-benzyl)-amine;
209) 4-[2-[l-(Butane-l-sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)-lH-imidazol-4- yl] -pyridin-2-ylamine;
210) 2-[5-Benzo[l,3]dioxol-5-yl-2-(l-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4- yl] -6-ethyl-pyridine;
211) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
212) 4-[5-(3-Methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-lH- imidazol-2-yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
213) N- {4-[5-(6-Methyl-pyridin-2-yl)-4-quinoxalin-6-yl- lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanesulfonamide;
214) N-{4-[5-(6-Methyl-pyridin-2-yl)-4-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-acetamide.
215) 4-[2-(6-Methyl-pyridin-2-yl)-pyrazolo[l ,5-a]pyridin-3-yl]-pyriraidin-2-ylamine;
216) 4-(2-pyridin-2-yl-pyrazolo[ 1 ,5-a]pyridin-3-yl)-pyrimidin-2-ylamine; 217) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyridin-3-yl]-pyrimidin-2-ylamine; 218) 2-(6-methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-pyrazolo[l,5-a]pyridine; 219) 4-[2-(6-chloro-pyridin-2-yl)-pyrazolo[l,5-c]pyrimidin-3-yl]-pyrimidin-2-ylaniine; 220) 2-(6-methyl-pyridin-2-yl)-3-(2-morpholin-4-yl-pyrimidm-4-yl)-pyrazolo[l,5- c]pyrimidine;
221) 4-[2-(6-methyl-pyridm-2-yl)-pyrazolo[l,5-a]pyrazin-3-yl]-pyrimidin-2-ylamine; 222) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-a]pyrimidm-3-yl]-pyrimidin-2-ylamine; 223) 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[l,5-c]pyrimidin-3-yl]-pyrimidin-2-ylamine;
224) (2-Methoxy-ethyl)- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
225) (3- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino} - propyl)-carbamic acid tert-butyl ester;
226) (3-Imidazol-l-yl-propyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
227) (4-Methoxy-benzyl)-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
228) [2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridin- 6-yl] -methanol; 229) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridine;
230) (4- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino } - butyl)-carbamic acid tert-butyl ester;
231) (4-Amino-benzyl)- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
232) (5- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2-ylamino } - pentyl)-carbamic acid tert-butyl ester;
233) [3-(2-Arnmo-pyrirnidin-4-yl)-2-(6-methyl-pyridin-2-yl)-irnidazo[l,2-a]pyridin-6-yl]- methanol;
234) [3-(2-ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-7-yl] - methanol;
235) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridin-8-yl]-(2-morpholin-4-yl-ethyl)-amine;
236) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]ρyridin-8-yl]-(2-pyridin-2-yl-ethyl)-amine;
237) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridm-8-yl]-(2-pyridin-3-yl-ethyl)-amine;
238) [3-(2-methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridin-6-yl]-methanol;
239) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridin-8-yl]-(2-pyridin-4-yl-ethyl)-amine;
240) [3-(2-Amino-pyrimidin-4-yl)-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- ajpyridin- 8 -yl] -(3 -morpholin-4-yl-propyl)-amine;
241) [3-(4-Methyl-piperazin- 1 -yl)-propyl]- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a]pyridin-3 -yl] -pyrimidin-2-yl} -amine;
244) [3-(4-Methyl-piperidin-l-yl)-propyl]-{4-[2-(6-methyl-pyridm-2-yl)-imidazo[l,2- a]pyridin-3-yl]-pyrimidin-2-yl}-amine;
245) [4-(2-Pyridm-2-yl-imidazo[l,2-a]pyridm-3-yl)-pyrimidin-2-yl]-pyridm-3-ylmethyl- amine;
246) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-((R)-l- phenyl-ethyl)-amine;
247) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-((S)-l- phenyl-ethyl)-amine; 248) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(lH- tetrazol-5 -yl)-amine;
249) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]ρyridin-3-yl]-pyrimidin-2-yl}-(2H- pyrazol-3-yl)-amine;
250) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2- morpholin-4-yl-ethyl)-amine;
251) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridm-3-yl]-pyrimidin-2-yl}-(2-pyridin- 2-yl-ethyl)-amine;
252) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(2-pyridin- 3 -yl-ethyl)-amine;
253) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidm-2-yl}-(2-pyridin- 4-yl-ethyl)-amine;
254) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}-(3- moφholin-4-yl-propyl)-amine;
255) {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-yl} -(3- piperidin- 1 -yl-propyl)-amine;
256) {4-[2-(6-Metliyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- [1 ,3,4]thiadiazol-2-yl-amine;
257) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridine; 258) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfaiiyl-pyrimidin-4-yl)-imidazo[l,2-a]pyridine- 6-carboxylic acid methyl ester;
259) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidm-4-yl)-imidazo[l,2-a]pyridine- 7-carboxylic acid ethyl ester;
260) 2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo [ 1 ,2- a]pyrimidin-7-ylamme;
261) {7,7-Dimethyl-8-[5-(4-{4-[2-(6-methyl-ρyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ylamino}-butylcarbarnoyl)-pentyl]-2-oxo-4-trifluoromethyl-7,8-dihydro-2H-l- oxa-8-aza-anthracen-5-yl} -methanesulfonic acid;
262) 2-(2,7-Difluoro-6-hydroxy-3-oxo-9,9a-dihydro-3H-xanthen-9-yl)-3,5,6-trifluoro-4-[(4- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- butylcarbamoyl)-methylsulfanyl]-benzoic acid;
263) -(6-Methyl-pyridm-2-yl)-3-(2-moipholin-4-yl-pyrimidm-4-yl)-irnidazo[l32-a]pyridine; 264) 2-(6-Methyl-pyridin-2-yl)-3-(2-piperidin-l-yl-pyrimidin-4-yl)-imidazo[l,2-a]pyridine; 265) 2-(6-Methyl-pyridin-2-yl)-3-(2-pyrrolidin-l-yl-pyrimidin-4-yl)-irnidazo[l,2-a]pyridine; 266) 2-(6-Methyl-pyridin-2-yl)-3-[2-(lH-tetrazol-5--yl)-pyrimidin-4-yl]-iniidazo[l,2- ajpyridine;
267) 2-(6-Methyl-pyridin-2-yl)-3-pyrimidin-4-yl-imidazo[l,2-a]pyridine;
268) 2-(6-Methyl-pyridin-2-yl)-3-pyrimidin-4-yl-imidazo[l,2-a]pyrimidin-7-ylamine;
269) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-8- ylamine;
270) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carbonitrile;
271) 3-(2-Aiiiino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridirie-6- carboxylic acid;
272) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide;
273) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide;
274) 3 -(2-Ammo-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid (2-dimethylamino-ethyl)-amide;
275) 3-(2-7\mmo-pyrimidin-4-yl)-2-(6-niethyl-pyridin-2-yl)-imidazo[l,2--a]pyridine-6- carboxylic acid (2-methoxy-ethyl)-amide;
276) 3 -(2- Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridine-6- carboxylic acid (2-thiophen-2-yl-ethyl)-amide;
277) 3-(2-Amino-pyrimidin-4-yl)-2-(6-niethyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid [3-(4-methyl-piperazin-l-yl)-propyl]-amide;
278) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid amide;
279) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carboxylic acid cyclopropylamide;
280) 3-(2-Amino-pyrirnidiri-4-yl)-2-(6-methyl-pyridin-2-yl)-irnidazo[l,2-a]pyridine-6- carboxylic acid ethylamide;
281) 3 -(2- Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridine-6- carboxylic acid hydroxyamide;
282) 3-(2-Amino-pyrirnidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridine-6- carboxylic acid methoxy-amide;
283) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-iinidazo[l,2-a]pyridme-6- carboxylic acid methyl ester; 284) 3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridi3ie-7- carboxylic acid;
285) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-iinidazo[l,2-a]pyridLiie-7- carboxylic acid ([l,4]dioxan-2-ylmethyl)-amide;
286) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (2-amino-ethyl)-amide;
287) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridiiie-7- carboxylic acid (2-dimethylamino-ethyl)-amide;
288) 3-(2-Amino-pyrirnidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridiiie-7- carboxylic acid (2-hydroxy-ethyl)-amide;
289) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid (2-oxo-2-pyridin-3-yl-ethyl)-amide;
290) 3-(2-Ammo-pyrirnidin-4-yl)-2-(6-methyl-pyridm-2-yl)-irnidazo[l,2-a]pyridirie-7- carboxylic acid (2-thiophen-2-yl-ethyl)-amide;
291 ) 3 -(2- Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-7- carboxylic acid (piperidin-3-ylmethyl)-amide;
292) 3-(2-Amino-pyrirnidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridirie-7- carboxylic acid 2,2-dimethylhydrazide;
293) 3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid amide;
294) 3 -(2- Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridine-7- carboxylic acid cyclopropylamide;
295) 3-(2-Ammo-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid ethyl ester;
296) 3-(2-Amino-pyrimidin-4-yl)-2-(6-metliyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid ethylamide;
297) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid hydroxyamide;
298) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridine-7- carboxylic acid methoxy-amide;
299) 3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[ 1 ,2-a]pyriinidin-7- ylamine;
300) 3-(2-Azetidin-l-yl-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridine;
301) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-ρyridin-2-yl)-irnidazo [ 1 ,2-a] pyridine-7-carboxylic acid ethyl ester; 302) 3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-metliyl-ρyridin-2-yl)-imidazo[l,2- a]pyridine-6-carboxylic acid methyl ester;
303) 3-(2-Methanesulforιyl-ρyrimidin-4-yl)-7-methyl-2-(6-niethyl-pyridin-2-yl)-imi<iazo[l,2- a] pyridine;
304) 3-(2-Methanesulfonyl-ρyrimidin-4-yl)-8-methyl-2-(6-methyl-pyridin-2-yl)-irnidazo[l,2- a] pyridine;
305) 3,3-Dimethyl-N-[2-(6-methyl-pyridin-2-yl)-3-(2-rnethylsulfanyl-pyrimidin-4-yl)- imidazo[l,2-a]pyrimidin-7-yl]-butyramide;
306) 3-(2-Methanesulfonyl-ρyrirnidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2- a]pyridine-6-carbonitrile;
307) 3 -(2-Methylsulfanyl-pyrimidin-4-yl)-2-pyridin-2-yl-imidazo [ 1 ,2-a]pyridine;
308) 3,6-Dichloro-N-(4- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ylamino}-bxιtyl)-2-(2,4,5,7-Tetrachloro-6-hydroxy-3-oxo-9,9a-dihydro-3H- xanthen-9-yl)-terephthalamic acid;
309) 3-[2-(2-Methyl-aziridin-l -yl)-pyrimidin-4-yl]-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a] pyridine;
310) 3- [2-(4-Methyl-pip erazin- 1 -yl)-pyrimidin-4-yl] -2-(6-methyl-pyridin-2-yl)-imidazo [1,2- a] pyridine;
311) 3- { [3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridine-6- carbonyl] -amino} -propionic acid methyl ester;
312) 3-{[3-(2-Amino-pyrimidin--4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyri<iine-7- carbonyl] -amino} -propionic acid methyl ester;
313) 3-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylanαino}- phenol;
314) 4-(2-{4-[2-(6-Meth.yl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}- ethyl)-benzenesulfonam.ide;
315) 4-(2-Pyridin-2-yl-imidazo[ 1 ,2-a]pyridin-3-yl)-pyrimidin-2-ylamine;
316) 4-[2-(6-Chloro-pyridm-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamme;
317) 4-[2-(6-Methyl-pyxidin-2-yl)-7-trifluoromethyl-imidazo[ 1 ,2-a]pyridin-3-yl]-ρyτimidin- 2-yl-amine;
318) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylamine;
319) 4-[2-(6-Methyl-pyτidin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidine-2-carboaitrile;
320) 4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidine-2-carbox:ylic acid amide; 321) 4-[6-Bromo-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
322) 4-[6-Chloro-2-(6-methyl-pyridin-2-yl)-iinidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
323) 4-[6-Fluoro-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
324) 4-[6-Methyl-2-(6-niethyl-pyridin-2-yl)-8-(2-morpholin-4-yl-ethylammo)-imidazo[ 1 ,2-a] pyridin-3-yl]-pyrimidin-2-ol;
325) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-2-yl-ethylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidin-2-ol;
326) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-3-yl-ethylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidin-2-ol;
327) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-(2-pyridin-4-yl-ethylamino)-imidazo[l,2-a] pyridin-3-yl]-pyrimidin-2-ol;
328) 446-Methyl-2-(6-methyl-pyridin-2-yl)-8-morpholin-4-yl-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ol;
329) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-8-morpholin-4-yl-imidazo[l,2-a]pyridin-3-yl]- pyrimidin-2-ylamine;
330) 4-[6-Methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridm-3-yl]-pyrimidm-2- ylamine;
331) 4-[7-Aminomethyl-2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2- yl-amine;
332) 4-[7-Methyl-2-(6-methyl-pyri<lin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
333) 4-[8-Benzyloxy-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ol;
334) 4-[8-Benzyloxy-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl- amine;
335) 4-[8-Bromo-6-methyl-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidm-
2-ol;
336) 4-[8-Methyl-2-(6-methyl-pyrid.in-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2- ylamine;
337) 6-Chloro-3-(2-methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2- a] pyridine;
338) 5-Dimethylamino-naphthalene-l -sulfonic acid (4-{4-[2-(6-methyl-pyridin-2-yl)- imidazof 1 ,2-a]pyridin-3 -yl] -pyrimidin-2-ylamino } -butyl)-amide; 339) 6-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-N-(4-{4-[2-(6-metliyl-pyridin-2-yl)- imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-ylamino}-butyl)-ϊsophthalamic acid;
340) 6- Amino-9-[2-carboxy-5 -(4- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3 -yl] - pyrimidin-2-ylamino } -butylcarbamoyl)-phenyl] -xanthen-3 -ylidene-ammonium;
341) 6-Bromo-2-(6-methyl-pyridin-2-yl)-3-(2-methylsulfaiiyl-pyrimidin-4-yl)-imidazo[l,2-a] pyridine;
342) 6-Fluoro-2-(6-methyl-pyridm-2-yl)-3-(2-methylsulfajayl-pyrimidin-4-yl)-imidazo[ 1 ,2-a] pyridine;
343) 7-Amino-4-methyl-3-[(4- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]- pyrimidin-2-ylamino}-butylcarbamoyl)-methyl]-2-oxo-2H[-chromene-6-sulfonic acid;
344) Cyclobutyl-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l-,2-a]pyridin-3-yl]-pyrimidin-2-yl}- amine;
345) Cyclopentyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridm-3-yl]-pyrimidin-2- yl} -amine;
346) Cyclopropyl- {4-[2-(6~methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]-pyrimidin-2- yl} -amine;
347) Cyclopropyl-methyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3-yl]- pyrimidin-2-yl} -amine;
348) Dimethyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-yl}- amine,
349) Isopropyl- {4-[2-(6-methyl-pyridin-2-yl)-imidazo[l ,2, -a]pyridin-3-yl]-pyrimidin-2-yl} - amine,
350) Methyl- {4-[2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrimidin-2-yl}- amine,
350a) N-(2-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-ρyrimidin-2- ylamino} -ethyl)-acetamide;
351) N-(4-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]p3rridin-3-yl]-pyrimidin-2-ylamino}- butyl)-acetamide;
352) N,N-Dimethyl-N'-{4-[2-(6-methyl-pyridin-2-yl)-imiciazo[l,2-a]pyridin-3-yl]-pyrimidm- 2-yl} -ethane-1 ,2-diamine;
353) N-[2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-p5τimidin-4-yl)-imidazo[l,2-a] pyrimidin-7-yl]-3-pyridin-3-yl-propionamide;
354) N-[2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-p3rrimidin-4-yl)-imidazo[l,2-a] pyrimidin-7-yl]-nicotinamide; 355) N-[2-(6-Methyl-pyridin-2-yl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[ 1 ,2-a] pyrimidin-7-yl]-propionamide;
356) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-6- carbonylj-methanesulfonamide;
357) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridine-7- carbonyl] -methanesulfonamide;
358) N-[3-(2-Ainino-pyriinidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyrimidin-7- yl]-2-(3-methoxy-phenyl)-acetamide;
359) N-[3-(2-Arnino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyrimidin-7- yl] -3 ,3 -dimethyl -butyr amide;
360) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyrimidin-7- yl] -3 -pyridin-3 -yl-propionamide;
361) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyrimidin-7- yl]-acetamide;
362) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyrimidin-7- yl] -nicotinamide ;
363) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a] pyrimidin-7-yl] -2-(3 -methoxy-phenyl)-acetamide;
364) N-[3-(2-Methanesulfonyl-pyrimidm-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7-yl] -3,3 -dimethyl-butyr amide;
365) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7-yl] - 3 -pyridin-3 -yl-propionamide;
366) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[ 1 ,2-a] pyrimidin-7-yl] -nicotinamide;
367) N-[3-(2-Methanesulfonyl-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a] pyrimidin-7-yl] -propionamide;
368) N-[3-(2-Amino-pyrimidin-4-yl)-2-(6-methyl-pyridin-2-yl)-imidazoπi,2-a]pyrimidin-7- yl] -propionamide;
369) N-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]pyridin-3-yl]-pyrirriidin-2-yl}- acetamide;
370) Nl - {4-[2-(6-Methyl-pyridin-2-yl)-imidazo [ 1 ,2-a]pyridin-3 -yl] -pyrimidin-2-yl} -butane-
1,4-diamine;
371) Nl-{4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l,2-a]ρyridin-3-yl]-pyrimidin-2-yl}- propane-1 ,3-diarnine; 372) N-(4- {4- [2-(6-Methyl-pyridin-2-yl)-imidazo[ 1 ,2-a]pyridin-3 -yl] -pyrimidin-2-ylamino } - butyl)-(BODIPY FL) amide; and
373) N-(4- {4-[2-(6-Methyl-pyridin-2-yl)-imidazo[l ,2-a]pyridin-3-yl]-pyrimidin-2-ylaniino} - butyl)-(Texas Red-X) amide
374) N-[3-(2-amino-pyrimidin-4-yl)-2-(6-methyl-pyridm-2-yl)-imidazo[l,2-a]pyrimidiix-7- yl]-acetamide;
375) N-{4-[2-(6-methyl-pyridin-2-yl)-imidazo[l,2-a]ρyridin-3-yl]-ρyrimidin-2-yl}- acetamide.
376) 3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l -yl)-propylamine,
377) N-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propyl]-acetamide,
378) N-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propyl]-methanesulfonamide,
379) dimethyl-[3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propyl]-amine,
380) 4-{3-pyridin-2-yl-l-[2-(lH-tetrazol-5-yl)-ethyl]-lH-pyrazol-4-yl}-quinoline,
381) 4- [3 -pyridin-2-yl- 1 -(3 -pyrrolidin- 1 -yl-propyl)- 1 H-pyrazol-4-yl]-quinoline,
382) 5-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-pyridin-2-ylamine, 383) 2,4-dimethoxy-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyrimidine, 384) 3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propionic acid, 385) 5-(3-pyridin-2-yl-lH-ρyrazol-4-yl)-lH-indole, 386) 2-[4-(2,3-dihydro-benzo[l,4]dioxin-6-yl)-lH-pyrazol-3-yl]-pyridine, 387) N-hydroxy-3-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-propionamide, 388) 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-l-yl)-ethylamine,
389) N- [2-(3 -pyridin^-yM-quinolin^-yl-pyrazol- 1 -yl)-ethyl] -methanesulfonamide,
390) 2-methyl-4-methylsulfanyl-6-(3-pyridm-2-yl-lH-pyrazol-4-yl)-pyrimidine,
391) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-pyridine,
392) 2-[4-(2,3-dihydro-benzofuran-5-yl)-lH-pyrazol-3-yl]-pyridine,
393) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[d]isoxazole,
394) 3-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-propionitrile,
395) N-{3-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-propyl}- methanesulfonamide,
396) 2-[4-(2,3-dihydro-benzo[l,4]dioxin-6-yl)-lH-pyrazol-3-yl]-6-methyl-pyridine,
397) [4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-acetonitrile,
398) N-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethyl}- methanesulfonamide,
399) 4-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-2-methylsulfanyl-pyrimidine,
400) 4-(3-pyridin-2-yl- 1 H-ρyrazol-4-yl)-2H-phthalazin- 1 -one, 40 ϊ) f -t5!k3-pyri'a&'2-yl-ffl-pyrazoϊ-4-yl)-2,3-dihydro-indo 402) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]pyridme,
403) 3-niethyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
404) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-4H-benzo[ 1 ,4]oxazin-3-one,
405) 6-(3-pyridin-2-yl- 1 H-pyrazol-4-yl)-quinoxaline, 406) 3-(4-nitro-benzyl)-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
407) 5 -methyl-6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl) - [ 1 ,2,4]triazolo[ 1 ,5-a]pyridine,
408) 4-methyl-7-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl) -3 ,4-dihydro- 1 H-benzo[e] [ 1 ,4] diazepine- 2,5-dione,
409) 2,3-dimethyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one, 410) 6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine,
41 Oa) 1 -methoxy-4-(3-pyridin-2-yl-lH-pyrazol-4-yl)-isoquinoline,
411) 2-methyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l,2,4]triazolo[l,5-a]pyridine,
41 Ia) 4-(3 -pyridin-2-yl- lH-pyrazol-4-yl)-2H-isoquinolin-l -one,
412) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-trifluoromethyl-pyridine,
412a) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-vinyl-pyridine,
413) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-propenyl-pyridine,
414) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-ethyl-pyridine,
415) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-propyl-pyridine,
416) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-cyclopropyl-pyridine,
417) 1 -[6-(4-benzo[l ,3]dioxol-5-yl-lH-pyrazol-3-yl)-pyridin-2-yl]-ethanol,
418) 4-methoxy-6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-quinazoline,
419) 6-(3-pyridin-2-yl- 1 H-pyrazol-4-yl)-quinoline, 420) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolIn-4-ylamine, 421) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one, 422) 7-(3-pyridin-2-yl-lH-pyrazol-4-yl)-pyrido[l 32-a]pyrimidin-4-one, 423) 6-[3-(6-cyclopropyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine,
424) 3-methyl-6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3H-quinazolin-4-one,
425) 4-(2- {2-[4-benzo[ 1 ,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l -yl]-ethoxy} - ethoxy)-bicyclo [2.2.2] octane- 1 -carboxylic acid,
426) 4-(2-{2-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-ethoxy}- ethoxy)-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester,
427) 4-[4-benzo[l ,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol- 1 -yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester,
428) 2-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-6-isopropyl-pyridine, 429) 2-(4-benzo[l,3]dioxol-5-yl-5-trifluoromethyl-lH-pyrazol-3-yl)-6-bromo-pyridine,
430) 6-[3-(5-fluoro-6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine,
431) 6-[3-(6-trifluoromethyl-pyridin-2-yl)-lH-pyrazol-4-yl]-[l ,2,4]triazolo[l ,5-a]pyridine,
432) 6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-quinoxaline,
432a) 6-[3-(6-cyclopropyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3-methyl-3H-quinazolm-4-one,
433) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-[l ,2,4]triazolo[l ,5-b]pyridazine,
433a) 6-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-quinoline,
434) 6-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-3-fluoro-2-methyl-pyridine,
435) 7-methoxy-3-methyl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3H-quinazolin-4-one,
436) (4-moφholm-4-yl-phenyl)-[6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-qumazolm-4-yl]-amine,
437) 4-isopropoxy-6-(3-pyridin-2-yl- 1 H-pyrazol-4-yl)-quinazoline,
438) 6-(3-Pyridin-2-yl-lH-pyrazol-4-yl)-quinolin-4-ylamine,
439) {4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohexyl}- carbamic acid benzyl ester,
440) 4-[4-benzo[ 1 ,3] dioxol-5 -yl-3-(6-methyl-pyridin-2-yl)-pyrazol- 1 -yl]-cyclohexylamine, 441) N-{4-[4-benzo[l,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-l-yl]-cyclohexyl}- methanesulfonamide,
442) 6-[3-(5-fluoro-6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-quinoxaline,
443) 7-(3-pyridin-2-yl- lH-ρyrazol-4-yl)-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridine,
444) 1 -tert-butyl-3 - [6-(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-quinazolin-4-yl] -urea,
445) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[l ,2,5]thiadiazole, 446) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[l,2,5]oxadiazole,
447) 5-(3 -Pyridin-2-yl- 1 H-pyrazol-4-yl)-benzooxazole,
448) 4-morpholin-4-yl-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline,
449) 6-[3-(6-trifluoromethyl-pyridin-2-yl)-lH-pyrazol-4-yl]-quinoxaline, 450) 4-(4-methoxy-phenyl)-6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazoline, 451) 5-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-benzo[l,2,5]thiadiazole,
452) 6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzothiazole,
453) 3-(3-methoxy-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
454) 5-methyl-thiophene-2-carboxylic acid [6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quinazolin-4- yl] -amide,
455) 5-[3-(6-methyl-pyridin-2-yl)-lH-pyrazol-4-yl]-3-phenyl-benzo[c]isoxazole,
456) 3-(4-methoxy-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole,
457) 3 -(4-chloro-phenyl)-5 -(3 -pyridin-2-yl- 1 H-pyrazol-4-yl)-benzo [c] isoxazole,
458) 3-(4-ethyl-phenyl)-5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-benzo[c]isoxazole, 459) (4-methoxy-phenyl)-[6-(3-pyridin-2-yl-lH-pyrazol-4-yl)-quirιazolin-4-yl]-metlianone, 460) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-3-thiophen-3-yl-benzo[c]isoxazole,
461) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid,
462) 5-(3-Pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid methylamide,
463) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid dimethylamide,
464) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylio acid (2,2-dimethyl- propyl)-amide,
465) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid phenylamide, 466) moφholin-4-yl-[5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazol-3-yl]-methanone,
467) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid benzylamide,
468) 5-(3-pyridin-2-yl-lH-pyrazol-4-yl)-lH-indazole-3-carboxylic acid cyclopentylamide, 469) 4-[4-benzo[l,3]dioxol-5-yl-5-(2-methylsulfanyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- benzamide; 470) 4-[4-benzo[l,3]dioxol-5-yl-5-(2-methylsulfanyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- benzonitrile; 471) 4-[5-(2-methanesulfonyl-pyrimidin-4-yl)-4-(6-methyl-pyridiπL-2-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
472) 4-[5-(2-methoxy-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-L H-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
473) 4-[5-(2-hydroxy-pyrimidm-4-yl)-4-(6-methyl-pyridin-2-yl)-lΗ-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
474) 4-[5.(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
475) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)- 1 H-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid;
476) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid amide;
477) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid hydroxyamide;
478) 4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]octane-l-carboxylic acid methoxy-amide;
479) 4-[5-(2-ammo-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)- 1 H-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
480) {4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-imidazol-2- yl]-bicyclo[2.2.2]oct-l-yl}-carbamic acid benzyl ester; 481) N-{4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridiri-2-yl)-lH-imidazol-
2-yl]-bicyclo[2.2.2]oct-l-yl}-acetamide;
482) N-{4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-methyl-pyridin-2-yl)-lH-iniidazol-
2-yl] -bicyclo [2.2.2] oct- 1 -yl} -methanesulfonamide;
483) N- {4-[5-(2-cyclopropylamino-pyrimidin-4-yl)-4-(6-metliyl-pyridin-2-yl)- 1 H-imidazol-
2-yl]-bicyclo[2.2.2]oct-l-yl}-2,2,2-trifluoro-acetamide;
484) 4-[5-qumoxalin-6-yl-4-(2-trifluoromethyl-pyrimidin-4-yl)-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
485) 4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-iinidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
486) 6-[2-tert-butyl-5-(2-cyclopropyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline;
487) 6-[5-(2-byclopropyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline;
488) {4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]oct-l-yl}-methanol;
489) 6-[5-(2-trifluoromethyl-pyrimidin-4-yl)-3H-imidazol-4-yl]-quinoxaline;
490) 6-[2-tert-butyl-5-(2-trifluoromethyl-pyrimidm-4-yl)-3H-imidazol-4-yl]-quinoxaline; 491) 4-[5-quinoxalin-6-yl-4-(2-trifluorometb.yl-pyrimidin-4-yl)-lH-imidazol-2-yl]- piperidine-1-carboxylic acid benzyl ester;
492) 4-[4-(2-cyclopropyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-iinidazol-2-yl]-piperidine-l- carboxylic acid benzyl ester;
493) 6-[5-(2-cyclopropyl-pyrirnidin-4-yl)-2-(l-methanesulfonyl-piperidin-4-yl)-3H-imidazol-
4-yl] -quinoxaline;
494) 4-[5-(2-methyl-pyrimidm-4-yl)-4-[l,2,4]triazolo[4,3-a]pyridm-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol;
495) 4-[4-(2-methyl-pyrimidin-4-yl)-5-[ 1 ,2,4]triazolo[ 1 ,5-a]pyridine-6-yl- lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l -carboxylic acid amide;
496) 4-[4-(2-methyl-ρyrimidin-4-yl)-5-[l,2,4]triazolo[l,5-a]pyridiiie-6-yl-lH-iniidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid;
497) 4-[4.(2-methyl-ρyrimidin-4-yl)-5-[l,2,4]triazolo[l,5-a]pyridine-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octane-l-carboxylic acid methyl ester;
498) 4-[4-(2-methyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]-cyclohexanol; and
499) 4-[4-(2-methyl-pyrimidin-4-yl)-5-quinoxalin-6-yl-lH-imidazol-2-yl]- bicyclo[2.2.2]octan-l-ol,
500) 4-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-2-methyl-pyrimidine,
500a) 6-[3-(2-methyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-[l52,4]triazolo[l,5-a]pyridine, 501) d-[3-(2-tπM'dfbm^
502) 6-[3-(2-methyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-quinoxaline,
502a) 6-[3 -(2-trifluoromethyl-pyrimidin-4-yl)- lH-pyrazol-4-yl] -quinoxaliire,
503) 6-[3-(2-cyclopropyl-pyrimidin-4-yl)-lH-pyrazol-4-yl]-quinoxaline,
504) 4-(4-benzo[l,3]dioxol-5-yl-lH-pyrazol-3-yl)-2-trifluoromethyl-pyrimidine,
505) 7-[3-(2-Mfluoromethyl-ρyrimidin-4-yl)-lH-pyrazol-4-yl]-[l,2,4]triazolo[l,5-a]pyridine, or
506) 6-[3-(2-Trifluoromethyl-pyrimidin-4-yl)- 1 H-pyrazol-4-yl]-quinoline.