WO2006043940A1 - Topical skin lightening cream - Google Patents
Topical skin lightening cream Download PDFInfo
- Publication number
- WO2006043940A1 WO2006043940A1 PCT/US2004/034228 US2004034228W WO2006043940A1 WO 2006043940 A1 WO2006043940 A1 WO 2006043940A1 US 2004034228 W US2004034228 W US 2004034228W WO 2006043940 A1 WO2006043940 A1 WO 2006043940A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- percent
- concentration
- skin lightening
- topical skin
- cream according
- Prior art date
Links
- 230000000699 topical effect Effects 0.000 title claims abstract description 45
- 239000006071 cream Substances 0.000 title claims description 53
- 206010040829 Skin discolouration Diseases 0.000 title claims description 47
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims abstract description 58
- 150000003431 steroids Chemical class 0.000 claims abstract description 45
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims abstract description 25
- 229960001727 tretinoin Drugs 0.000 claims abstract description 25
- 230000000475 sunscreen effect Effects 0.000 claims abstract description 24
- 239000000516 sunscreening agent Substances 0.000 claims abstract description 24
- 230000037072 sun protection Effects 0.000 claims abstract description 10
- 238000011282 treatment Methods 0.000 claims abstract description 10
- 206010010356 Congenital anomaly Diseases 0.000 claims abstract description 7
- 230000002500 effect on skin Effects 0.000 claims abstract description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 32
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 28
- 229960000890 hydrocortisone Drugs 0.000 claims description 14
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 12
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 6
- 229960003471 retinol Drugs 0.000 claims description 6
- 235000020944 retinol Nutrition 0.000 claims description 6
- 239000011607 retinol Substances 0.000 claims description 6
- 229960005294 triamcinolone Drugs 0.000 claims description 5
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims description 5
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical group [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 46
- 238000009472 formulation Methods 0.000 description 19
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000003974 emollient agent Substances 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 239000003755 preservative agent Substances 0.000 description 5
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 3
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 3
- -1 PEG-100 stearate Chemical compound 0.000 description 3
- 208000012641 Pigmentation disease Diseases 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 3
- 229960005193 avobenzone Drugs 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- 230000028709 inflammatory response Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 229960001679 octinoxate Drugs 0.000 description 3
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 3
- 229940001584 sodium metabisulfite Drugs 0.000 description 3
- 235000010262 sodium metabisulphite Nutrition 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- 206010008570 Chloasma Diseases 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- 206010034972 Photosensitivity reaction Diseases 0.000 description 2
- 206010036229 Post inflammatory pigmentation change Diseases 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 206010064127 Solar lentigo Diseases 0.000 description 2
- 206010043189 Telangiectasia Diseases 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 2
- 229960000601 octocrylene Drugs 0.000 description 2
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 2
- 229960001173 oxybenzone Drugs 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 2
- 229960003415 propylparaben Drugs 0.000 description 2
- 208000009056 telangiectasis Diseases 0.000 description 2
- OQQOAWVKVDAJOI-UHFFFAOYSA-N (2-dodecanoyloxy-3-hydroxypropyl) dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCC OQQOAWVKVDAJOI-UHFFFAOYSA-N 0.000 description 1
- XMFXBMLFOSSELI-UHFFFAOYSA-N 2-octyldodecyl 12-octadecanoyloxyoctadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(CCCCCC)CCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC XMFXBMLFOSSELI-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical class C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000021710 Hyperpigmentation disease Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- 206010037867 Rash macular Diseases 0.000 description 1
- 241000219053 Rumex Species 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229940073669 ceteareth 20 Drugs 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 229940086555 cyclomethicone Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000007854 depigmenting agent Substances 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Chemical class 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 229940074049 glyceryl dilaurate Drugs 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 208000000069 hyperpigmentation Diseases 0.000 description 1
- 230000003810 hyperpigmentation Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 208000013469 light sensitivity Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 229940100460 peg-100 stearate Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Chemical class 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001296 polysiloxane Chemical class 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical class [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 230000008833 sun damage Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Definitions
- the present invention is a novel topical cream formulation used for reducing the appearance of dermatological blemishes. More particularly, to reduce or eliminate the appearance of melasma, solar lentigo, post- inflammatory hyperpigmentation and other non-congenital hyperpigmentation diseases .
- a variety of skin lightening products are currently available on the market. Some of these employ a single active ingredient while others employ a formulation of two or more additive or synergistic compounds. Unfortunately the effect of a single ingredient is usually limited and each known formula has notable disadvantages and often introduces unintentional side effects concomitant with treatment of the primary condition of undesired pigmentation.
- TrilumaTM which contains 4% hydroquinone, tretinoin and a fluorinated steroid
- United States patent 6,699,464 describes a composition containing hydroquinone, rumex extract and sunscreen cream sun protection factor 15, ClaripelTM which contains 4% hydroquinone and sunscreen cream sun protection factor 15 (SPF 15) and GlyquinTM which contains 4% hydroquinone, glycolic acid and sunscreen cream SPF 15.
- ClaripelTM which contains 4% hydroquinone and sunscreen cream sun protection factor 15 (SPF 15)
- GlyquinTM which contains 4% hydroquinone, glycolic acid and sunscreen cream SPF 15.
- Tretinoin is an effective treatment for both wrinkles and skin pigmentation but is also known to cause skin sensitivity that can lead to skin darkening.
- Sunscreen may ) be used to protect from sun damage but is not effective in treating inflammation that often accompanies application of hydroquinone or tretinoin.
- Steroids can be used to counteract the inflammatory effect of hydroquinone and tretinoin, however, if the i strength of the steroid is too great such as the case with using fluorinated steroids there is a ris k of developing telangiectasia.
- the present invention provides a topical skin lightening cream for the treatment of non-congenital dermal blemishes comprising, hydroquinone, tretinoin, a low potency steroid and sunscreen.
- the concentration of hydroquinone is not less than 2 percent and not more than 12 percent, preferably not less than 4 percent and not more than 10 percent and most preferably 8 percent.
- the concentration of tretinoin is not less than 0.01 percent and not more than 0.10 percent, preferably not less than 0.03 percent and not more than 0.08 percent and most preferably 0.05 percent.
- the steroid is a low potency steroid selected from class 5, 6 or 7 steroids.
- the steroid is hydrocortisone or triamcilinone.
- hydrocortisone When hydrocortisone is the steroid of choice its concentration is preferably not less than 0.5 percent and not more than 10.0 percent, preferably not less than 1.0 percent and not more than 5.0 percent, most preferably 2.5 percent.
- the steroid When the steroid is triamcilinone it is preferably unfluorinated triamcilinone at a concentration not less than 0.01 percent and not more than 0.1 percent. Preferably not less than 0.025 percent and not more than 0.05 percent most preferably 0.05 percent.
- the sunscreen preferably has a sun protection factor of not less than 15 and not more than 50.
- the topical skin lightening cream further comprises an excipient.
- the excipient is metabisulfite.
- the topical skin lightening cream may further comprise glycolic acid at a concentration not less than 5.0 percent and not more than 15.0 percent.
- the glycolic acid is not less than 8.0 percent and not more than 12.0 percent. Most preferably the concentration of glycolic acid is 10.0 percent.
- a topical skin lightening cream is provided that is less potent and may be provided to consumers over the counter.
- This topical skin lightening cream comprises hydroquinone, retinol, a low potency steroid and sunscreen.
- concentration of hydroquinone is not more than 2 percent; the concentration of retinol is not more than 0.5 percent; the steroid is a class 5 steroid preferably hydrocortisone of a concentration of about 1.0 percent; and the sunscreen has a sun protection factor of not less than 15 and not more than 50.
- the topical skin lightening cream further comprising glycol ' ic acid at a concentration not more than about 20 percent.
- the topical skin lightening cream may further comprise, one or more antioxidants, one or more excipients, one or more preservatives, one or more emulsifiers, and/or one or more emollients .
- the present invention provides a novel topical composition for the treatment of non-congenital dermal blemishes, such as melasma, a type of hyperpigmentation that appears as dark blotchy clusters on the face often caused by hormonal fluctuations in pregnancy, birth control pills or hormone replacement therapy; solar lentigo, dark spots that result from exposure to the sun; and post- inflammatory hyperpigmentation, the dark discoloration that sometimes appears after acne heals or with trauma.
- the composition comprises hydroquinone, tretinoin, sunscreen and a low potency steroid.
- the composition comprises not less than about 2 percent and not more than about 12 percent hydroquinone, preferably not less than about 4 percent and not more than about 10 percent and most preferably about 8 percent.
- the composition comprises not less than about 0.01 percent and not more than about 0.10 percent tretinoin, preferably not less than about 0.03 percent and not more than about 0.08 percent and most preferably about 0.05 percent.
- the sunscreen cream preferably has a SPF of not less than about 15 and not more than about 50.
- Each individual patient may experience differing sun light sensitivity consequently those having a more violent reaction may desire a higher SPF sunscreen cream then those with a more mild reaction who might prefer a lower SPF sunscreen cream.
- the compositions of the present invention include sunscreens which in combination with other ingredients provide a composition which has a SPF of at least 15. To provide a formula with a SPF value of not less than 15 usually requires the use of more than a single UVB sunscreen.
- Suitable UVB sunscreens for use in the compositions of the present invention include avobenzone, octyl methoxycinnamate (also known as octinoxate) , oxybenzone and octocrylene.
- Avobenzone additionally functions as the preferred UVA sunscreen, however it is not measured as part of the SPF value.
- the amount of octyl methoxycinnamate, octocrylene, oxybenzone and/or avobenzone in a given formulation will vary depending on the sun protection factor desired. Preferably a higher sun protection factor such as SPF 50 is desirable.
- the low potency steroid is preferably selected from class 5, 6 or 7 steroids. Because each patient is unique they may experience different inflammatory responses to the hydroquinone and tretinoin depending on the concentration provided in the composition. Consequently, those having a stronger inflammatory response may desire an increased potency steroid such as a class 5 steroid or an increased concentration of a lower class steroid. A class 5 or lower steroid would be of sufficient strength to minimize any inflammatory effects from higher concentrations of hydroquinone but not cause undesired adverse effects such as telangiectasia. Correspondingly those individuals with a mild inflammatory response may desire a lower potency steroid such as a class 7 steroid or a lower concentration of the steroid.
- the low potency steroid may be hydrocortisone or triamcilinone.
- the low potency steroid is hydrocortisone cream it is preferably provided in a concentration not less than about 0.5 percent and not more than about 10.0 percent, particularly preferred concentrations are not less than 1.0 percent to not more than 5.0 percent and most preferably about 2.5 percent.
- the low potency steroid is triamcilinone it is preferably not fluorinated and of a concentration not less than about 0.01 percent and not more than about 0.1 percent, particularly preferred concentrations are not less than about 0.025 percent to not more than about 0.05 percent and most preferably about 0.05 percent.
- composition of the present invention may further comprise an excipient that may aid in the application of the formulation, effective uptake of the formulation, preserving the formulation or any combination thereof.
- excipients are available commerrcially and may be utilized in the formulation of the present invention.
- the excipient is metaloisulfite.
- Emulsifiers and emollients are used to provide a suitable texture and impart the characteristics of a vanishing cream. Any suitable emollients and emulsifiers can be used in the present composit-Lon.
- suitable emulsifiers/emollients include, for example: ceteareth-20, cetostearyl alcohol, diethylaminethyl stearate, glyceryl dilaurate, glyceryl monostearate, glyceryl stearate, PEG-100 stearate, octyldodecyl stearoyl stearate, polysorbate 80, quaternium-2 ⁇ , stearyl alcohol.
- the emulsifiers and emollients may generally comprise from about 20 percent to about 50 percent b>y weight of the formulation.
- Other moisturizers that may be included in the formulation include for example sodium PCA, dimethicone, cyclomethicone, propylene glycol and polysiloxane derivatives .
- composition of the present invention can also include antioxidants which enhance the dermatologically useful effect of the formulation.
- suitable antioxidants include vitamin E, sodium metabisulfite and propyl gallate.
- concentration of antioxidants may range from about 0.02 percent to about 1 percent by weight of the formulation, and preferably in the range from about 0.05 percent to about 0.5 percent by weight of the formulation. Any antioxidants, which are compatible with the present formulation, can be used.
- composition may further comprise glycolic acid to increase the absorption efficiency of hydroquinone and assist in the skin lightening effect of the formulation.
- concentration of glycolic acid is not less than about 5.0 percent and not more than about 15.0 percent, particularly preferred concentrations are not less than about 8.0 percent and not more than about 12.0 percent, and most preferably about 10.0 percent.
- the formulations of the present invention may further comprise antimicrobial preservatives.
- Any suitable preservatives can be used in the present composition.
- suitable preservatives include for example methyl paraben, propyl paraben and butylated hydroxytoluene.
- Formulations of the present invention may further comprise agents that increase the viscosity of the final formulation such as for example xanthum gum.
- a less potent composition may be provided as an over-the-counter formulation for reducing wrinkles and skin lightening comprising hydroquinone, retinol, sunscreen and low potency steroid.
- the composition comprises hydroquinone, tretinoin, sunscreen and a low potency steroid.
- the composition comprises not more than 2 percent hydroquinone, not more than 0.5 percent retinol a known effective treatment for both wrinkles and skin pigmentation similar to tretinoin, a low potency steroid, preferably class 5 such as hydrocortisone, at a concentration of about 1.0 percent and sunscreen (non-paba) having SPF of not less than about 15 and not more than about 50.
- this composition may further comprise glycolic acid at a concentration of not more than 20 percent.
- compositions above may be prepared by mixing to homogeneity the four compounds, hydroquinone, tretinoin, sunscreen and low potency steroid in an amount based on the desired percentage by weight.
- an excipient may be added as desired to facilitate use as a cream, as a preservative or as an agent to assist in the uptake of the hydroquinone, tretinoin or low potency steroid.
- a concentration of glycolic acid may also be added to the formulation to enhance or increase uptake of the active ingredients of the composition or as an additional skin- lightening agent based on the desired percentage by weight.
- One preferred method of making the composition includes boiling and then cooling an appropriate volume of water to 75 degrees C, and dissolving methyl para ' ben, and sodium metabisulfite to form a first solution; this is followed by cooling the first solution, and adding propylene glycol as an aqueous solution, and hydroqminone, triamcinolone and tretinoin to form a second soLution. Next, the following ingredients are combined and hea r ted to 65 degree C to form a uniform composition Solbar, propyl paraben, xanthum gum, Vitamin E and butyl hydroxytoluene this is added to the second solution to achieve a ⁇ niform combined composition.
- a preferred composition of the present invention comprises the following active ingredients: Percentage
- Trie following compositions was prepared in accordance with trie present invention: grams Percentage
- the gram amounts listed above are for a formulation having a final weight of 750 grams.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2004/034228 WO2006043940A1 (en) | 2004-10-15 | 2004-10-15 | Topical skin lightening cream |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2004/034228 WO2006043940A1 (en) | 2004-10-15 | 2004-10-15 | Topical skin lightening cream |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006043940A1 true WO2006043940A1 (en) | 2006-04-27 |
Family
ID=36203253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/034228 WO2006043940A1 (en) | 2004-10-15 | 2004-10-15 | Topical skin lightening cream |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006043940A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009063491A2 (en) * | 2007-09-11 | 2009-05-22 | Glenmark Pharmaceuticals Limited | Topical compositions for skincare |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3856934A (en) * | 1970-06-24 | 1974-12-24 | A Kligman | Skin depigmentation |
US5989596A (en) * | 1997-06-09 | 1999-11-23 | Coletica | Compositions comprising a depigmenting agent consisting of sulfites and metabisulfites and plant extracts for use in inhibiting melanogenesis or for depigmenting |
US6749840B2 (en) * | 2001-05-02 | 2004-06-15 | New York University | Inhibition of pigmentation by inhibition of fatty acid synthase |
-
2004
- 2004-10-15 WO PCT/US2004/034228 patent/WO2006043940A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3856934A (en) * | 1970-06-24 | 1974-12-24 | A Kligman | Skin depigmentation |
US5989596A (en) * | 1997-06-09 | 1999-11-23 | Coletica | Compositions comprising a depigmenting agent consisting of sulfites and metabisulfites and plant extracts for use in inhibiting melanogenesis or for depigmenting |
US6749840B2 (en) * | 2001-05-02 | 2004-06-15 | New York University | Inhibition of pigmentation by inhibition of fatty acid synthase |
Non-Patent Citations (2)
Title |
---|
CLARK J.: "Cream Combo Melasma "Drug of Choice"", DEMATOLOGY TIMES, vol. 23, no. 5, May 2002 (2002-05-01), pages 1 - 2, XP008062911 * |
GUEVARA I.L. ET AL: "Melasma Treated with Hydroquinone, Tretinoin, and a Fluorinated Stereoid", INTERNATIONAL J. OF DERM., vol. 40, no. 3, March 2001 (2001-03-01), pages 210 - 215, XP008062384 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009063491A2 (en) * | 2007-09-11 | 2009-05-22 | Glenmark Pharmaceuticals Limited | Topical compositions for skincare |
WO2009063491A3 (en) * | 2007-09-11 | 2009-11-19 | Glenmark Pharmaceuticals Limited | Topical compositions for skincare |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6699464B1 (en) | Compositions for treatment of hyperpigmentation and methods for making and using such compositions | |
US4610978A (en) | Compositions containing 1α-hydroxycholecalciferol for topical treatment of skin disorders and methods employing same | |
KR101295789B1 (en) | Skin treatment compositions | |
MXPA04000002A (en) | Agent containing fat (oil), which contains onion extract, the production and use thereof for caring, preventing or treating damaged skin tissue, especially scarred tissue. | |
US20060029556A1 (en) | Aqueous-alcoholic depigmenting gels | |
JP2013501067A (en) | Vitamin D sunscreen formulation for treatment and method for using it | |
USRE33107E (en) | Compositions containing 1α-hydroxycholecalciferol for topical treatment of skin disorders and methods employing same | |
US20110236503A1 (en) | Topical Skincare Composition | |
CN112587446A (en) | Composition for treating acne and preparation method and application thereof | |
KR20190013101A (en) | Composition for preventing or treating scar | |
US20080057138A1 (en) | Restorative skin cream | |
WO2009020518A1 (en) | Topical acne vulgaris composition with a sunscreen | |
KR20130055182A (en) | Composition for improving acnes and kit for improving acnes containing the same | |
EP1529520A1 (en) | Use of licochalcone A or a licochalcone A containing extract from Radix Glycyrrhizae inflatae against postinflammatory hyperpigmentation | |
WO2009063491A2 (en) | Topical compositions for skincare | |
WO2006043940A1 (en) | Topical skin lightening cream | |
US20060083697A1 (en) | Topical skin lightening cream | |
EP0421110B1 (en) | Synergistic skin depigmentation composition | |
EP0968707A2 (en) | Compositions against acne and inflamed comedones containing serine proteases and one or more calcium salts | |
US20110274727A1 (en) | Depigmenting topical compositions and their uses | |
US20030194385A1 (en) | Pharmaceutical formulations containing solubilized hydroquinone, salicylic acid and hydrocortisone for the treatment of melasma and related dermatological problems | |
EP1337220A2 (en) | Compositions having comfrey and methods for reducing retinoid-induced skin irritation | |
AU2015210366A1 (en) | Therapeutic vitamin d sun-protecting formulations and methods for their use | |
US20180185258A1 (en) | Skin care compositions | |
CN112336688A (en) | Oil-in-water type compound hydroquinone emulsion as well as preparation method and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 04795400 Country of ref document: EP Kind code of ref document: A1 |