WO2006043171A3 - Methods of using alpha2delta-1 selective compounds - Google Patents

Methods of using alpha2delta-1 selective compounds Download PDF

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Publication number
WO2006043171A3
WO2006043171A3 PCT/IB2005/003174 IB2005003174W WO2006043171A3 WO 2006043171 A3 WO2006043171 A3 WO 2006043171A3 IB 2005003174 W IB2005003174 W IB 2005003174W WO 2006043171 A3 WO2006043171 A3 WO 2006043171A3
Authority
WO
WIPO (PCT)
Prior art keywords
determining
methods
ligand
agent
subtype
Prior art date
Application number
PCT/IB2005/003174
Other languages
French (fr)
Other versions
WO2006043171A2 (en
Inventor
Ti-Zhi Su
Original Assignee
Warner Lambert Co
Ti-Zhi Su
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Ti-Zhi Su filed Critical Warner Lambert Co
Publication of WO2006043171A2 publication Critical patent/WO2006043171A2/en
Publication of WO2006043171A3 publication Critical patent/WO2006043171A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention is directed to methods of using compounds with selectivity for the α2δ-1 calcium channel subunit subtype. Methods for determining whether a test agent binds to an α2δ-1 polypeptide, for screening for a test agent that binds to an α2δ-1 polypeptide, for determining α2δ-1 or α2δ-2 selectivity of an agent, for quantifying binding sites of a specific α2δ-1 selective (ASL-1) ligand in a biological sample, for quantifying ASL1 binding sites in a biological sample, for determining the tissue distribution of α2δ-1, for determining the subtype occupancy of an agent, and for determining the subtype occupancy of an α2δ-1 ligand, are provided. The invention also includes articles of manufacture comprising vessels containing a specific α2δ-1 selective ligand.
PCT/IB2005/003174 2004-10-23 2005-10-10 Methods of using alpha2delta-1 selective compounds WO2006043171A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62118604P 2004-10-23 2004-10-23
US60/621,186 2004-10-23

Publications (2)

Publication Number Publication Date
WO2006043171A2 WO2006043171A2 (en) 2006-04-27
WO2006043171A3 true WO2006043171A3 (en) 2007-03-29

Family

ID=36203328

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003174 WO2006043171A2 (en) 2004-10-23 2005-10-10 Methods of using alpha2delta-1 selective compounds

Country Status (1)

Country Link
WO (1) WO2006043171A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000068184A1 (en) * 1999-05-10 2000-11-16 Warner-Lambert Company Aromatic amides
WO2000076958A2 (en) * 1999-06-10 2000-12-21 Warner-Lambert Company Mono- and disubstituted 3-propyl gamma-aminobutyric acids
WO2001020336A2 (en) * 1999-09-16 2001-03-22 Warner-Lambert Company SCREENING FOR α2δ-1 SUBUNIT BINDING LIGANDS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000068184A1 (en) * 1999-05-10 2000-11-16 Warner-Lambert Company Aromatic amides
WO2000076958A2 (en) * 1999-06-10 2000-12-21 Warner-Lambert Company Mono- and disubstituted 3-propyl gamma-aminobutyric acids
WO2001020336A2 (en) * 1999-09-16 2001-03-22 Warner-Lambert Company SCREENING FOR α2δ-1 SUBUNIT BINDING LIGANDS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GONG H C ET AL: "Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes", JOURNAL OF MEMBRANE BIOLOGY, vol. 184, no. 1, 1 November 2001 (2001-11-01), pages 35 - 43, XP002380949, ISSN: 0022-2631 *
HILL DAVID R ET AL: "Localization of tritiated gabapentin to a novel site in rat brain: Autoradiographic studies", EUROPEAN JOURNAL OF PHARMACOLOGY MOLECULAR PHARMACOLOGY SECTION, vol. 10, no. 3, 1993, pages 303 - 309, XP002404700, ISSN: 0922-4106 *

Also Published As

Publication number Publication date
WO2006043171A2 (en) 2006-04-27

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