WO2006042542A3 - Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin - Google Patents

Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin Download PDF

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Publication number
WO2006042542A3
WO2006042542A3 PCT/DK2005/000636 DK2005000636W WO2006042542A3 WO 2006042542 A3 WO2006042542 A3 WO 2006042542A3 DK 2005000636 W DK2005000636 W DK 2005000636W WO 2006042542 A3 WO2006042542 A3 WO 2006042542A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal
tetanus
media containing
toxoids
diphtheria
Prior art date
Application number
PCT/DK2005/000636
Other languages
French (fr)
Other versions
WO2006042542A2 (en
Inventor
Susanne Aamand
Jesper Westphal Petersen
Original Assignee
Statens Seruminstitut
Susanne Aamand
Jesper Westphal Petersen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Statens Seruminstitut, Susanne Aamand, Jesper Westphal Petersen filed Critical Statens Seruminstitut
Publication of WO2006042542A2 publication Critical patent/WO2006042542A2/en
Publication of WO2006042542A3 publication Critical patent/WO2006042542A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention discloses that non-animal and non-soy based result in increased growth of C.tetani, C.diphteriae, and B.pertussis and result in equivalent or increased yield of tetanus toxin, diphteria toxin and pertussis toxin, respectively, compared to cultivation of the bacteria in media containing animal-derived or soy-derived proteinaceous material. Preferably the proteinaceous hydrolysates are derived from wheat, a mixture of rice and wheat, from potato, or from yeast.
PCT/DK2005/000636 2004-10-19 2005-10-05 Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin WO2006042542A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200401595 2004-10-19
DKPA200401595 2004-10-19
DKPA200500110 2005-01-21
DKPA200500110 2005-01-21

Publications (2)

Publication Number Publication Date
WO2006042542A2 WO2006042542A2 (en) 2006-04-27
WO2006042542A3 true WO2006042542A3 (en) 2006-12-07

Family

ID=36095798

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2005/000636 WO2006042542A2 (en) 2004-10-19 2005-10-05 Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin

Country Status (1)

Country Link
WO (1) WO2006042542A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0505996D0 (en) * 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
PL1869161T3 (en) 2005-10-11 2010-07-30 Probiotical Spa Method for the preparation of anallergic probiotic bacterial cultures and related use
KR101220239B1 (en) * 2008-04-01 2013-01-09 바이오스펙트럼 주식회사 Composition for Promoting Stem Cell Proliferation Comprising Vegetable Peptone
EP2592137A1 (en) 2011-11-11 2013-05-15 Novartis AG Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
DE102011122891B4 (en) 2011-11-11 2014-12-24 Novartis Ag Fermentation medium, which is free of animal components, for the preparation of diphtheria toxoids for use in the vaccination of humans
DE102011118371B4 (en) 2011-11-11 2014-02-13 Novartis Ag Composition suitable for human vaccination, comprising a diphtheria toxoid, and process for its preparation
GB2495341B (en) 2011-11-11 2013-09-18 Novartis Ag Fermentation methods and their products
WO2014009971A2 (en) 2012-07-07 2014-01-16 Bharat Biotech International Limited Non-alcoholic vaccine compositions free from animal- origin and process for preparation thereof
CN104263687A (en) * 2014-09-29 2015-01-07 成都欧林生物科技股份有限公司 Animal origin free culture medium for bordetella pertussis and culture method of animal origin free culture medium
KR101723167B1 (en) * 2015-04-28 2017-04-05 주식회사 대웅 Medium Composition for Preparing Botulinum Toxin
KR101723168B1 (en) * 2015-04-28 2017-04-05 주식회사 대웅 Medium Composition for Preparing Botulinum Toxin
KR101729251B1 (en) 2015-04-28 2017-04-21 주식회사 대웅 Medium Composition for Preparing Botulinum Toxin
CN106282277A (en) * 2015-06-12 2017-01-04 天津康希诺生物技术有限公司 A kind of culture medium for preparing tetanus toxin and application thereof
SG11201901394XA (en) 2016-09-02 2019-03-28 Sanofi Pasteur Inc Neisseria meningitidis vaccine
EP3632465A1 (en) 2018-10-03 2020-04-08 Sanofi Pasteur Inc. Combined immunization against meningococcal disease and human papillomavirus
KR102209159B1 (en) * 2019-03-29 2021-01-29 (주)제테마 A Method for Producing a Toxin
KR102197224B1 (en) * 2019-03-29 2020-12-31 (주)제테마 A Composition for Culturing Bacteria
KR102447441B1 (en) * 2019-04-15 2022-09-27 (주)제테마 A Purification Method of Botulinum Toxin
KR102516204B1 (en) * 2019-04-15 2023-03-30 (주)제테마 A Purification Method of Botulinum Toxin
TW202136518A (en) * 2019-12-20 2021-10-01 瑞士商葛德瑪控股公司 Method of producing botulinum toxin
CN112646747B (en) * 2021-01-08 2024-03-15 苏州聚微生物科技有限公司 Clostridium tetani culture medium
WO2023200704A1 (en) 2022-04-11 2023-10-19 Sanofi Pasteur Inc. Protein-saccharide conjugation with sodium cyanoborohydride
CN117535211B (en) * 2024-01-09 2024-04-16 中国医学科学院医学生物学研究所 Culture medium combination of diphtheria bacillus and preparation method of diphtheria toxoid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054296A1 (en) * 1997-05-28 1998-12-03 Chiron S.P.A. Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin
WO2001005997A2 (en) * 1999-07-16 2001-01-25 Massachusetts Institute Of Technology Method for production of tetanus toxin using media substantially free of animal products
WO2004083400A2 (en) * 2003-03-18 2004-09-30 Cascade Biologics, Inc. Animal product-free cell culture media extracts, supplements and culture media supplement systems
WO2005056773A1 (en) * 2003-12-12 2005-06-23 Sanofi Pasteur Limited Production of diphtheria toxin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054296A1 (en) * 1997-05-28 1998-12-03 Chiron S.P.A. Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin
WO2001005997A2 (en) * 1999-07-16 2001-01-25 Massachusetts Institute Of Technology Method for production of tetanus toxin using media substantially free of animal products
WO2004083400A2 (en) * 2003-03-18 2004-09-30 Cascade Biologics, Inc. Animal product-free cell culture media extracts, supplements and culture media supplement systems
WO2005056773A1 (en) * 2003-12-12 2005-06-23 Sanofi Pasteur Limited Production of diphtheria toxin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"scientific research 2003/2004 / Fluka catalogue", 2003, FLUKA CHEMIE GMBH, XP002377083 *
LARKIN M: "Vegetarian option for biotech drugs could cut BSE risk", LANCET INFECTIOUS DISEASES, US, vol. 2, no. 12, December 2002 (2002-12-01), pages 715, XP004816264, ISSN: 1473-3099 *
WHITMER M E ET AL: "DEVELOPMENT OF IMPROVED DEFINED MEDIA FOR CLOSTRIDIUM BOTULINUM SEROTYPES A, B, AND E", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, WASHINGTON,DC, US, vol. 54, no. 3, March 1988 (1988-03-01), pages 753 - 759, XP008040512, ISSN: 0099-2240 *

Also Published As

Publication number Publication date
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