WO2006040680A1 - Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline - Google Patents
Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline Download PDFInfo
- Publication number
- WO2006040680A1 WO2006040680A1 PCT/IB2005/003236 IB2005003236W WO2006040680A1 WO 2006040680 A1 WO2006040680 A1 WO 2006040680A1 IB 2005003236 W IB2005003236 W IB 2005003236W WO 2006040680 A1 WO2006040680 A1 WO 2006040680A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- varenicline
- pharmaceutically acceptable
- acceptable salt
- composition according
- composition
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 95
- 229960004751 varenicline Drugs 0.000 title claims abstract description 67
- JQSHBVHOMNKWFT-DTORHVGOSA-N varenicline Chemical compound C12=CC3=NC=CN=C3C=C2[C@H]2C[C@@H]1CNC2 JQSHBVHOMNKWFT-DTORHVGOSA-N 0.000 title claims abstract description 67
- 230000002685 pulmonary effect Effects 0.000 title claims abstract description 23
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Definitions
- Varenicline is also known as 5,8,14-tr ⁇ azatetracyclo[10 3 1 O 2 11 0 4 9 ]-hexadeca-
- Varenicline and pharmaceutically acceptable acid addition salts thereof are referred to in International Patent Publication WO 99/35131 , published July 15, 1999, the contents of which are incorporated herein by reference
- Varenicline binds to neuronal nicotinic acetylcholine specific receptor sites and is useful in modulating cholinergic function Accordingly, this compound is useful in the treatment of various conditions or diseases including, but not limited to, inflammatory bowel disease (including, but not limited to, ulcerative colitis, pyoderma gangrenosum and Crohn's disease), irritable bowel syndrome, spastic dystonia, chronic pain, acute pain, celiac sprue, pouchitis, vasoconstriction, anxiety, panic disorder, depression, bipolar disorder, autism, sleep
- inflammatory bowel disease including, but not limited to, ulcerative colitis, pyoderma gangrenosum and Crohn's disease
- irritable bowel syndrome spastic dystonia, chronic pain, acute pain, cel
- varenicline via intranasal, buccal, or pulmonary routes.
- intranasal, buccal, sublingual or pulmonary delivery of varenicline provides for rapid absorption, faster onset of therapeutic action and avoidance of liver first pass metabolism.
- the nasal, buccal, sublingual and pulmonary delivery route options of varenicline are preferred. Delivery of varenicline or its suitable pharmaceutical salts, herein referred to as the active ingredient, can be achieved in an intranasal, buccal, sublingual and pulmonary composition.
- varenicline having immediate release formulations which can be administered via intranasal, buccal, and pulmonary routes.
- the present invention provides a composition for nasal administration comprising varenicline or its pharmaceutically acceptable salt and an effective amount of an absorption- promoting agent to promote nasal absorption of the varenicline or its pharmaceutically acceptable salt after nasal administration of the composition thereof. Additionally, the present invention provides a composition for buccal administration comprising varenicline or its pharmaceutically acceptable salt and at least one excipient to form a solid dosage form with the varenicline or its pharmaceutically acceptable salt, wherein the solid dosage form disintegrates in an oral cavity at body temperature and adheres to body tissue of the oral cavity via direct adhesion to tissue or entrapment of the dosage form as in between the gum and inner cheek.
- the present invention also provides a composition for sublingual administration comprising varenicline or its pharmaceutically acceptable salt and at least one excipient to form a solid dosage form with the varenicline or its pharmaceutically acceptable salt, wherein the solid dosage form disintegrates in an oral cavity at body temperature under the tongue.
- the present invention provides a composition for pulmonary administration comprising varenicline or its pharmaceutically acceptable salt and at least one excipient combined with the varenicline or its pharmaceutically acceptable salt.
- the present invention provides a method for reducing nicotine addiction, aiding in the cessation of, or lessening of, tobacco use in a subject. DETAILED DESCRIPTION OF THE INVENTION
- the present invention provides various compositions and related methods for intranasal, buccal, and pulmonary delivery of varenicline or its pharmaceutically acceptable salts
- the present invention utilizes varenicline or its pharmaceutically acceptable salt as the active ingredient
- Varenicline can be used per se or in the form of its pharmaceutically acceptable salt, solvate and/or hydrate
- any pharmaceutically acceptable form of varenicline can be used in connection with the present invention, it is preferable to use a salt form of the drug
- a particularly preferred salt form of the drug is the L-tartrate salt
- the present invention provides a method for reducing nicotine addiction or aiding in the cessation or lessening of tobacco use in a subject
- the method includes steps of administering to a subject an amount of the immediate-release varenicline that is effective in reducing nicotine addiction or aiding in the cessation or lessening of tobacco use via administration via the intranasal, buccal, sublingual or pulmonary routes
- the present invention can be used to treat disorders or conditions including,
- buccal delivery means a method for drug absorption through the buccal ( ⁇ e , inner cheek) tissue
- sublingual delivery means delivery of the active compound of the present invention across any tissue under the tongue
- transmucosal deliver/' as used herein means delivery of the active compound of the present invention across any mucosal membrane
- Varenicline means the drug that binds to neuronal nicotinic acetylcholine specific receptor sites, and is useful in modulating cholinergic function Varenicline has the general formula of
- Varenicline includes the parent drug and all pharmaceutically acceptable salts and prodrugs thereof
- the parent drug of varenicline is described in International Patent Publication WO 99/35131 , published July 15, 1999, the contents of which are incorporated herein by reference in their entirety
- varenicline or any of its pharmaceutically acceptable salts, solvates and/or hydrates can be used Procedures for making varenicline are described in U S Patent No 6,410,550, the contents of which are incorporated herein by reference in their entirety
- the resolution of racemic mixtures of varenicline is described in WO01 /62736, which is also incorporated herein by reference in its entirety
- mgA refers to the number of milligrams of active drug based on the free base form of the drug
- pharmaceutically acceptable means the substance or composition must be compatible chemically, physically, and/or toxicologically, with the other ingredients comprising a formulation, and/or the mammal being treated therewith
- salt derivatives include, but are not limited to, hahdes, thiocyanates, sulfates, bisulfates, sulfites, bisulfites, arylsulfonates, alkylsulfates, phosphonates, monohydrogen-phosphates, dihydrogenphosphates, metaphosphates, pyrophosphonates, alkanoates, cycloalkylalkanoates, arylalkonates, adipates, alginates, aspartates, benzoates, fumarates, glucoheptanoates, glycerophosphates, lactates, maleates, nicotinates, oxalates, palmitates, pectinates, picrates, pivalates, succinates, tartarates, citrates, camphorates, camphorsulfonates, digluconates, trifluor
- ⁇ or "suitable period of time” means the period of time necessary to achieve a desired effect or result
- a mixture can be blended until a potency distribution is reached that is within an acceptable range for a given application or use of the blended mixture
- unit dose means a physically discrete unit that contains a predetermined quantity of active ingredient calculated to produce a desired therapeutic effect
- the dosage form can be in the form including, but not limited to, tablets, a bioadhesive patch or film, lozenges, hard candies, wafers, lollipops, sprays, gums, pills, pellets, spheres, and other forms known to those of skill in the art
- an effective amount means the amount determined by such considerations as are known in the art of reducing nicotine addiction or aiding in the cessation or lessening of tobacco use in an individual, wherein it must be effective to provide measurable relief in treated individuals such as exhibiting improvements including, but not limited to, more rapid recovery, improvement or elimination of symptoms or reduction of complications, lack of dependency upon nicotine-containing compounds, lack of desire towards nicotine-containing compounds, or other measurements as appropriate and known to those skilled in the medical arts
- compositions of varenicline can be desirably administered in doses ranging from about 0 1 mgA up to about 6 mgA per day (where mgA refers to mg of active drug based on the free base form of the drug), more preferably from about 0 5 to 4 mgA/day, and most preferably from about 1 to 4 mgA per day in single or divided doses Variations in such dosages, however, necessarily occur depending upon the weight and condition of the subject being treated Depending on individual responses, dosage levels below the lower limit of the aforesaid range can be more than adequate, while in other cases still larger doses can be employed without causing any harmful side effects
- the final pharmaceutical composition is processed into a unit dosage form and then packaged for distribution The processing step varies depending upon the particular unit dosage form For example, a tablet is generally compressed under pressure into a desired shape Those of skill in the art are well aware of the procedures used for manufacturing the various unit dosage forms In any embodiments of the present invention, the active blend of a dosage form
- intranasal, buccal, sublingual or pulmonary formulations are made of other ingredients including, but not limited to, excipients, diluents, binders, lubricants, glidants, disintegrants, carriers, flavors and mixtures thereof.
- acceptable other ingredients include but are not limited to starch, mannitol, kaolin, calcium sulfate, inorganic salts (e.g., sodium chloride), powdered cellulose derivatives, tribasic calcium phosphate, calcium sulfate, magnesium carbonate, magnesium oxide, poloxamers such as polyethylene oxide, hydroxypropyl methylcellulose, anionic excipients, cationic excipients, zwitterionic excipients (See, US Patent Number 6,436,950, which is incorporated herein by reference in its entirety), polymeric hydrogel, powder microsphere mucoadhesive compositions, thiolated polymeric excipients, polycationic material, chitosan, cross-linked starches, fats, carbohydrates, polyols, buffers, phosphate buffers, acetate buffers, methocel, sodium chloride, water, lactic acid, benzalkonium chloride, demineralized water, cellulose, microcrystalline cellulose
- Suitable grades of dicalcium phosphate include anhydrous (about 135 to 180 ⁇ m mean, available from PenWest Pharmaceuticals Co., Patterson, NY or Rhodia, Cranbury, NJ), and dihydrate (about 180 ⁇ m, available from PenWest Pharmaceuticals Co., Patterson, NY or Rhodia, Cranbury, NJ).
- the microcrystalline cellulose is present in an amount from about 10 wt% to about 70 wt% and the dicalcium phosphate is present in an amount from about 10 wt% to about 50 wt%. More preferably, microcrystalline cellulose is present in an amount of about 30-70 wt% and the dicalcium phosphate is present in an amount of about 20-40 wt%.
- examples of glidants include, but are not limited to, silicon dioxide, talc, cornstarch, combinations thereof, and any other similar glidants known to those of skill in the art.
- a binder may be added.
- Suitable binders include substances such as celluloses (e.g., cellulose, methylcellulose, ethylcellulose, hydroxypropyl cellulose and hydroxymethylcellulose), polypropylpyrrolidone, polyvinylprrolidone, gelatin, gum arabic, polyethylene glycol, starch, natural and synthetic gums (e.g., acacia, alginates, and gum arabic) and waxes.
- a lubricant is typically used in a tablet formulation to prevent the tablet and punches from sticking in the die.
- Suitable lubricants include calcium stearate, glyceryl monostearate, glyceryl palmitostearate, hydrogenated vegetable oil, light mineral oil, magnesium stearate, mineral oil, polyethylene glycol, sodium benzoate, sodium lauryl sulfate, sodium stearyl fumarate, stearic acid, talc and zinc stearate.
- a preferred lubricant is magnesium stearate.
- the magnesium stearate is generally present in an amount from about 0.25 wt% to about 4.0% wt%.
- Other Ingredients such as disintegrants may also be added to the composition to break up the dosage form and release the compound.
- Suitable disintegrants include sodium starch glycolate, sodium carboxymethyl cellulose, calcium carboxymethyl cellulose, croscarmellose sodium, polyvinylpyrrolidone, methyl cellulose, microcrystalline cellulose, powdered cellulose, lower alkyl-substituted hydroxypropyl cellulose, polacrilin potassium, starch, pregelatinized starch and sodium alginate.
- croscarmellose sodium and sodium starch glycolate are preferred, with croscarmellose sodium being most preferred.
- the croscarmellose sodium is generally present in an amount from about 0.5 wt% to about 6.0 wt%.
- the amount of disintegrant included in the dosage form will depend on several factors, including the properties of the dispersion, the properties of the porosigen (discussed below), and the properties of the disintegrant selected. Generally, the disintegrant will comprise from 1 wt% to 15 wt%, preferably from 1 wt% to 10 wt% of the dosage form.
- glidants include silicon dioxide, talc and cornstarch.
- acceptable other ingredients include, but are not limited to carriers and excipients such as but not limited to ion-exchange microspheres which carry suitable anionic groups such as carboxylic acid residues, carboxymethyl groups, sulphopropyl groups and methylsulphonate groups.
- Ion-exchange resins cation exchangers
- Chitosan which is partially deacetylated chitin, or poly-N-acetyl-D-glucosamine, or a pharmaceutically acceptable salt thereof such as hydrochloride, lactate, glutamate, maleate, acetate, formate, propionate, malate, malonate, adipate, succinate.
- Suitable other ingredients for use as non-ion-exchange microspheres include starch, gelatin, collagen and albumin.
- composition may further comprise an appropriate acid selected from the group consisting of hydrochloric acid, lactic acid, glutamic acid, maleic acid, acetic acid, formic acid, propionic acid, malic acid, malonic acid, adipic acid, succinic acid
- an appropriate acid selected from the group consisting of hydrochloric acid, lactic acid, glutamic acid, maleic acid, acetic acid, formic acid, propionic acid, malic acid, malonic acid, adipic acid, succinic acid
- Excipients to enhance absorption may also be used and further include phospholipids, e.g. phosphatidylglycerol or phosphatidylcholines; or lysophosphatidyl derivatives, e.g. lysolecithin, lysophosphatidyl- ethanolamine, lysophosphatidylcholine, lysophosphatidylglycerol, lysophosphatidylserine, lysophosphatidic acid, cyclodextrins. Gelling excipients or viscosity-increasing excipients may be added.
- phospholipids e.g. phosphatidylglycerol or phosphatidylcholines
- lysophosphatidyl derivatives e.g. lysolecithin, lysophosphatidyl- ethanolamine, lysophosphatidylcholine, lysophosphatid
- ingredients such as diluents are cellulose, microcrystalline cellulose, hydroxypropyl cellulose, starch, hydroxypropylmethyl cellulose and the like
- the intranasal compositions may also contain one or more preservatives selected from quaternary ammonium salts such as lauralkonium chloride, benzalkonium chloride, benzododecinium chloride, cetyl pyridium chloride, cetrimide, domiphen bromide; alcohols such as benzyl alcohol, chlorobutanol, o-cresol, phenyl ethyl alcohol; organic acids or salts thereof such as benzoic acid, sodium benzoate, potassium sorbate, parabens; or complex forming agents such as EDTA.
- quaternary ammonium salts such as lauralkonium chloride, benzalkonium chloride, benzododecinium chloride, cetyl pyridium chloride, cetrimide, domiphen bromide
- alcohols such as benzyl alcohol, chlorobutanol, o-cresol, phenyl ethyl alcohol
- organic acids or salts thereof such
- Excipients to adjust the tonicity of the composition may be added such as sodium chloride, glucose, dextrose, mannitol, sorbitol, lactose and the like. Additionally acid or basic buffers may be added to the intranasal composition to control the pH. Pulmonary Dosage Forms
- phospholipids such as phosphatidylcholine, such as dipalmitoylphosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylserine.
- the phospholipids can be present in the formulation in the amount from about 0 to about 90 wt %.
- the phospholipids can be present in the composition in the amount from about 10 to about 60 wt. %.
- the formulation can include a surfactant, herein referring to any agent which preferentially absorbs to an interface between two immiscible phases, such as the interface between water and an organic polymer solution, a water/air interface or organic solvent/air interface.
- a surfactant herein referring to any agent which preferentially absorbs to an interface between two immiscible phases, such as the interface between water and an organic polymer solution, a water/air interface or organic solvent/air interface.
- surfactants may also promote absorption of a therapeutic or diagnostic agent and increase bioavailability of the agent.
- Suitable surfactants include but are not limited to hexadecanol; fatty alcohols such as polyethylene glycol (PEG); polyoxyethylene-9-lauryl ether; a surface active fatty acid, such as palinitic acid or oleic acid; glycocholate; surfactin; a poloxomer; a sorbitan fatty acid ester such as sorbitan trioleate (Span 85); and tyloxapol.
- the surfactant can be present in the composition in an amount ranging from about 0 to about 90 weight %. Preferably, it can be present in the composition in an amount ranging from about 10 to about 60 weight %.
- suitable surfactants include but are not limited to hexadecanol; fatty alcohols such as polyethylene glycol (PEG); polyoxyethylene-9-lauryl ether; a surface active fatty acid, such as palmitic acid or oleic acid, glycocholate, surfactin, a poloxomer, a sorbitan fatty acid ester such as sorbitan trioleate (Span 85), and tyloxapo
- composition can also optionally include an amino acid Hydrophobic amino acids are preferred Suitable amino acids include naturally occurring and non-naturally occurring hydrophobic amino acids Examples of amino acids which can be employed include, but are not limited to glycine, proline, alanine, 5 eysteme, methionine, valine, leucine' tyro sine, isoleucine, phenylalanine, tryptophan
- the pulmonary composition can also include excipients such as, for example, dextran, polysaccharides, trehalose, cyclodextrins, proteins, peptides, polypeptides, fatty acids, inorganic salts such as sodium chloride or calcium chloride, organic acid salts such as sodium citrate and phosphates such as sodium dihydrogen phosphate
- excipients such as, for example, dextran, polysaccharides, trehalose, cyclodextrins, proteins, peptides, polypeptides, fatty acids, inorganic salts such as sodium chloride or calcium chloride, organic acid salts such as sodium citrate and phosphates such as sodium dihydrogen phosphate
- reducing carbohydrates are sugars and their derivatives that contain a free aldehyde or ketone group capable of acting as a reducing agent through the donation of electrons
- reducing carbohydrates include monosaccharides and disaccharides and more specifically include lactose, glucose, fructose, maltose and other similar sugars
- a volume mean diameter drug substance particle size of less than or equal to about 60 microns is preferably utilized.
- the composition for intranasal delivery includes varenicline or its pharmaceutically acceptable salts combined with various other ingredients known to those of skill in the art and as set forth above Further, the composition can provide an initial rapid release of the active ingredient followed by a sustained release of the active ingredient
- U S Patent Number 5,629,011 provides examples of this type of formulation and is incorporated herein by reference in its entirety
- compositions that utilize intranasal delivery and related methods thereof Moreover, there are numerous methods and related delivery vehicles that provide for intranasal delivery of various pharmaceutical compositions
- intranasal compositions that employ current marketed nicotine replacement therapies See, N J Benowitz, Drugs, 45, 157-170, 1993, which is incorporated herein by reference in its entirety
- polymer or cyclodext ⁇ n formulations can be used to enhance the bioavailability of the active ingredient of the present invention at the mucosal surface (See, U S Patent Numbers 5,324,718 and 5,472,954,
- nasal delivery compositions are chitosan-based and are suitable to increase the residence time of the active ingredient of the present invention on mucosal surfaces, which results in increasing its bioavailability
- Examples of these nasal delivery compositions are disclosed in U S Patent Numbers 6,465,626, 6,432,440, 6,391 ,318, and 5,840,341 , European Patent Numbers EP0993483 and EP1051190, and International Publication Numbers WO 96/05810, WO 96/03142, and WO 93/15737, all of which are incorporated herein by reference in their entirety
- compositions according to the invention can be administered by any appropriate method according to their form
- a composition including microspheres or a powder can be administered using a nasal insufflator device
- these devices are already employed for commercial powder systems intended for nasal application (e g , Fisons Lomudal System)
- the insufflator produces a finely divided cloud of the dry powder or microspheres
- the insufflator is preferably provided with a mechanism to ensure administration of a substantially fixed amount of the composition
- the powder or microspheres can be used directly with an insufflator, which is provided with a bottle or container for the powder or microspheres
- the powder or microspheres can be filled into a capsule such as a gelatin capsule, or other single dose device adapted for nasal administration
- the insufflator preferably has a mechanism to break open the capsule or other device
- varenicline Relative to an oral dosage form such as a tablet or capsule intranasal delivery of varenicline provides for rapid absorption, faster onset of therapeutic action and avoidance of liver first pass metabolism For patients who have difficulty in swallowing tablets, capsules or other solids or those who have intestinal failure the intranasal delivery route of varenicline is preferred Further, the composition can provide an initial rapid release of the active ingredient followed by a sustained release of the active ingredient
- a composition including a solution or dispersion in an aqueous medium can be administered as a spray for intranasal delivery of the active ingredient by using an appropriate device such as a metered dose aerosol valve or a metered dose pump
- an appropriate device such as a metered dose aerosol valve or a metered dose pump
- a gas or liquid propellant can be used Details of other devices are disclosed in the following patents, patent applications and publications WO03/026559, WO02/11800, WO00/51672, WO02/068029, WO02/068030, WO02/068031 , WO02/068032, WO03/000310, WO03/020350, WO03/082393, WO03/084591 , WO03/090812, WO00/41755, and the pharmaceutical literature (See, Bell, A Intranasal Delivery Devices, in Drug Delivery Devices Fundamentals and Applications, TyIe P (ed), Dekker, New York, 1988), Remington
- Transport of the active ingredient of the present invention across normal mucosal surfaces such as the nasal, pulmonary, buccal or sublingual mucosa can be enhanced by optionally combining it with an absorption promoting agent such as those disclosed in US Patents 5,629,011 , 5,023,252, 6,200,591 , 6,369,058, 6,380,175, and International Publication Number WO 01/60325, all of which are incorporated herein by reference in their entirety
- absorption promoting agents include, but are not limited to, cationic polymers, surface active agents, chelating agents, mucolytic agents, cyclodextrin, polymeric hydrogels, combinations thereof, and any other similar absorption promoting agents known to those of skill in the art
- Polymeric hydrogel-forming compositions, which exhibit muco-adhesion and controlled drug release properties can also be optionally included in the intranasal compositions of the present invention Examples of such formulations are disclosed in U S Patent Numbers 6,068,852 and 5,814,329, and International Public
- a composition including a solid dosage form for transmucosal, and preferably buccal or sublingual delivery
- the solid dosage form can be immediate release or controlled release, wherein the dosage form disintegrates and/or melts in the oral cavity at body temperature with or without the aid of fluids, salivary fluids, mechanical erosion, or combinations thereof
- the dosage form can be sprayed into the oral cavity in the form of a solution spray or a dry powder Relative to an oral dosage form such as a tablet or capsule buccal delivery of varenicline provides for rapid absorption, faster onset of therapeutic action and avoidance of liver first pass metabolism
- the buccal or sublingual delivery route of varenicline is preferred
- the composition can provide an initial rapid release of the active ingredient followed by a sustained release of the active ingredient.
- the composition may be adhesive towards the body tissue lining the oral cavity of the individual.
- the dosage form can be, but is not limited to, tablets, a bioadhesive patch or film, lozenges, hard candies, wafers, lollipops, sprays, gums, pills, pellets, spheres, combinations thereof, and other forms known to those of skill in the art.
- compositions and delivery vehicles suitable for buccal or sublingual delivery of the active ingredient of the present invention are disclosed in US Patent Numbers 6,676,959, 6,676,931 , 6,593,317, 6,552,024, 6,306,914, 6,284,264, 6,248,358, 6,210,699, 6,177,096, 6,197,331 , 6,153,222, 6,126,959, 6,286,698, 6,264,981 , 6,187,323, 6,173,851 , 6,110,486, 5,955,098, 5,869,082, 5,985,31 1 , 5,948,430, 5,753,256, 5,487,902, 5,470,566, 5,362,489, 5,288,498, 5,288,497, 5,269,321 , 6,488,953, 6,126,959, 6,641 ,838, 6,576,250, 6,509,036, 6,391 ,335, 6,365,182, 6,280,770, 6,221 ,392, 6,
- a composition and related method for pulmonary delivery Relative to an oral dosage form such as a tablet or capsule buccal delivery of varenicline provides for rapid absorption, faster onset of therapeutic action and avoidance of liver first pass metabolism. For patients who have difficulty in swallowing tablets, capsules or other solids or those who have intestinal failure the pulmonary delivery route of varenicline is preferred. Further, the composition can provide an initial rapid release of the active ingredient followed by a sustained release of the active ingredient.
- compositions for pulmonary delivery according to the present invention can be administered by any appropriate method according to their form.
- particles administered to the respiratory tract travel through the upper airways (oropharynx and larynx), the lower airways which include the trachea followed by bifurcations into the bronchi and bronchioli and through the tenninal bronchioli which in turn divide into respiratory bronchioli leading then to the ultimate respiratory zone, the alveoli or the deep lung.
- most of the mass of particles deposits in the deep lung or alveoli. This includes solutions or dispersions in an aqueous medium can be administered as a spray with an atomizer to create droplets with narrow size distributions.
- a composition including microspheres or a powder can be administered using a nasal insufflator device herein mentioned above.
- the insufflator produces a finely divided cloud of the dry powder or microspheres.
- the insufflator is preferably provided with a mechanism to ensure administration of a substantially fixed amount of the composition.
- the powder or microspheres can be used directly with an insufflator, which is provided with a bottle or container for the powder or microspheres.
- the powder or microspheres can be filled into a capsule such as a gelatin capsule, or other single dose device adapted for nasal administration
- the insufflator preferably has a mechanism to break open the capsule or other device
- a liquid formulation is prepared by dissolving 150 mg of varenicline tartrate in 10 ml of a 0 5% solution of medium viscosity grade of Chitosan (80% degree of deacetylation obtained from Protan Limited)
- the substituted cyclodextrin material beta-cyclodext ⁇ n (Sigma Chemical, Co ) is added to provide a concentration of 5%
- the liquid formulation is administered to the nose using a conventional pump spray device
- a bioadhesive powder formulation of varenicline tartrate is prepared using microspheres of cross-linked starch
- the microspheres are prepared by the method described in GB 1518121 and EP 223302 described above and incorporated herein by reference in their entirety
- a preferred size of microspheres is 1-100 micrometers
- varenicline tartrate 75 mg is dissolved in 30 ml water and mixed with 1 g of starch microspheres The product is freeze-d ⁇ ed to produce a free flowing powder The final concentration of varenicline tartrate in the product is 0 05 mg/mg of starch microspheres The powder is administered to the nasal cavity using an insufflator device The quantity administered is 1 0 mg microspheres per kg body weight containing 0 05 mg varenicline tartrate
- a nasal spray solution is exemplified herein Varenicline tartrate (1 5 g) is dissolved in 100ml 0 05M Phosphate buffer (pH 4 4) and sufficient sodium chloride is added to the solution to make it isotonic The solution is placed in a nasal administrator designed to deliver
- aqueous nasal gel is exemplified herein
- the aqueous nasal gel includes the following components
- varenicline free base 12 4 mg, 1 24% w/w
- Demmeralized water is added to obtain a final volume of 1 ml
- Sodium chloride then is added (5 mg, 0 5% w/w)
- the resulting solution is stored in small vials of about 125 micro liters These vials are adapted to fit into one unidose spraying device, which delivers about 100 micro liters of solution
- Each dose of 100 microliters contains approximately 1 2 mg of varenicline free base EXAMPLE 6
- Varenicline tartrate is ground in a mortar to an average particle size of 5 ⁇ m
- 180 mg of microcrystalline cellulose FMC Biopolymer, Philadelphia, PA, Avicel PH101 with a 90 % w/w average particles size of 63 to 150 ⁇ m
- 20 mg of hydroxypropyl cellulose Aqualon, Wilmington, DE HPC-H with a 90 % w/w average particles size of 10 to 100 ⁇ m
- 0 16 mg of magnesium stearate is added to form a mixture
- the resulting mixture is blended to prepare a powder composition EXAMPLE 7:
- a solid dosage form for buccal absorption is produced by melting 67 6 gm Akoprime E (a hydrogenated vegetable oil type Il NF 18, Karlshamns, AB, Karlshamn, Sweden), at 40°C until a clear solution is obtained At 40°C, xylitol (10 gm), cacao (16 9 gm), and a flavoring agent are added in portions and under homogenization until a visually dispersed system is obtained after which varenicline free base (0 25 gm) is added At 40° C, the mixture was further homogenized after which 5 gm egg lecithin (purified egg phospholipids) is added under continued homogenization. The obtained mixture is dispensed and molded in blisters and cooled to room temperature resulting in pieces ranging from 0.4 to about 0.8 g. There is 3.13 mg of varenicline per 0.8 gm dosage form.
- Akoprime E a hydrogenated vegetable oil type Il NF 18, Karlshamns, AB, Karlshamn, Sweden
- EXAMPLE 8 Preparation of a pulmonary dry powder composition of varenicline Varenicline free base( 0.01 g ) and 2.0 g dipalmitoylphosphatidylcholine (DPPC)
- Varenicline tartrate (0.01 g) is dissolved in 50 mL of ethanol. To this solution is dissolved 0.01 g of ascorbic acid. The resulting solution can be used in loaded into an aerosol metered dose inhalation device charged with a suitable propellant such as dichlorodifluormethane or dichlortetrafluoroethane.
- a suitable propellant such as dichlorodifluormethane or dichlortetrafluoroethane.
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CA002583101A CA2583101A1 (en) | 2004-10-15 | 2005-10-06 | Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline |
BRPI0515932-6A BRPI0515932A (en) | 2004-10-15 | 2005-10-06 | compositions and methods for intranasal, buccal, sublingual and pulmonary distribution of varenicline |
EP05812628A EP1802276A1 (en) | 2004-10-15 | 2005-10-06 | Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline |
JP2007536289A JP2008516942A (en) | 2004-10-15 | 2005-10-06 | Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline |
MX2007004495A MX2007004495A (en) | 2004-10-15 | 2005-10-06 | Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline. |
Applications Claiming Priority (2)
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US61909404P | 2004-10-15 | 2004-10-15 | |
US60/619,094 | 2004-10-15 |
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WO2006040680A1 true WO2006040680A1 (en) | 2006-04-20 |
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ID=35759196
Family Applications (1)
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PCT/IB2005/003236 WO2006040680A1 (en) | 2004-10-15 | 2005-10-06 | Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline |
Country Status (7)
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US (1) | US20060084656A1 (en) |
EP (1) | EP1802276A1 (en) |
JP (1) | JP2008516942A (en) |
BR (1) | BRPI0515932A (en) |
CA (1) | CA2583101A1 (en) |
MX (1) | MX2007004495A (en) |
WO (1) | WO2006040680A1 (en) |
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- 2005-10-06 CA CA002583101A patent/CA2583101A1/en not_active Abandoned
- 2005-10-06 EP EP05812628A patent/EP1802276A1/en not_active Withdrawn
- 2005-10-06 MX MX2007004495A patent/MX2007004495A/en unknown
- 2005-10-06 BR BRPI0515932-6A patent/BRPI0515932A/en not_active Application Discontinuation
- 2005-10-06 WO PCT/IB2005/003236 patent/WO2006040680A1/en active Application Filing
- 2005-10-06 JP JP2007536289A patent/JP2008516942A/en active Pending
- 2005-10-14 US US11/251,171 patent/US20060084656A1/en not_active Abandoned
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WO2018160043A1 (en) * | 2017-03-03 | 2018-09-07 | 주식회사 씨티씨바이오 | Preparation, comprising inclusion complex of varenicline or pharmaceutically acceptable salt thereof, for oral administration |
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WO2023275413A3 (en) * | 2021-12-23 | 2023-03-09 | Medichem, S.A. | Solid pharmaceutical formulations of varenicline |
Also Published As
Publication number | Publication date |
---|---|
US20060084656A1 (en) | 2006-04-20 |
BRPI0515932A (en) | 2008-08-12 |
JP2008516942A (en) | 2008-05-22 |
CA2583101A1 (en) | 2006-04-20 |
EP1802276A1 (en) | 2007-07-04 |
MX2007004495A (en) | 2007-05-10 |
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