WO2006039675A3 - Apparatus and method for nanomanipulation of biomolecules and living cells - Google Patents

Apparatus and method for nanomanipulation of biomolecules and living cells Download PDF

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Publication number
WO2006039675A3
WO2006039675A3 PCT/US2005/035551 US2005035551W WO2006039675A3 WO 2006039675 A3 WO2006039675 A3 WO 2006039675A3 US 2005035551 W US2005035551 W US 2005035551W WO 2006039675 A3 WO2006039675 A3 WO 2006039675A3
Authority
WO
WIPO (PCT)
Prior art keywords
electromagnetic
core
particles
biomolecules
living cells
Prior art date
Application number
PCT/US2005/035551
Other languages
French (fr)
Other versions
WO2006039675A2 (en
Inventor
Donald E Ingber
Benjamin D Matthews
David A Lavan
Darryl Overby
Original Assignee
Childrens Medical Center
Donald E Ingber
Benjamin D Matthews
David A Lavan
Darryl Overby
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center, Donald E Ingber, Benjamin D Matthews, David A Lavan, Darryl Overby filed Critical Childrens Medical Center
Publication of WO2006039675A2 publication Critical patent/WO2006039675A2/en
Publication of WO2006039675A3 publication Critical patent/WO2006039675A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

The present invention relates to an electromagnetic needle for magnetically manipulating microscopic particles and a method of making the same, and more particularly, to a method for nanomanipulating biomolecules and/or living cells using the electromagnetic needle of the present invention. The temperature-controlled electromagnetic microneedle includes an electromagnetic core having a magnetic probe tip. A wire coil is wound around at least a portion of the core and electrically isolated from the core. A thermo-regulating water jacket having a first and second end and enveloping the electromagnetic core and wire coil allows the probe tip to extend from the first end. Magnetically responsive particles upon which a biologically active substance is absorbed are administered to a subject. A catheter having a magnet attached thereto is inserted into the body of the subject. The magnet guides the particles to a site to be treated with the biologically active substance.
PCT/US2005/035551 2004-10-01 2005-10-03 Apparatus and method for nanomanipulation of biomolecules and living cells WO2006039675A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61499904P 2004-10-01 2004-10-01
US60/614,999 2004-10-01

Publications (2)

Publication Number Publication Date
WO2006039675A2 WO2006039675A2 (en) 2006-04-13
WO2006039675A3 true WO2006039675A3 (en) 2006-06-29

Family

ID=36143152

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/035551 WO2006039675A2 (en) 2004-10-01 2005-10-03 Apparatus and method for nanomanipulation of biomolecules and living cells

Country Status (1)

Country Link
WO (1) WO2006039675A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9694103B2 (en) 2003-04-16 2017-07-04 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
US7635734B2 (en) 2004-02-17 2009-12-22 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
US9028829B2 (en) 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US8562505B2 (en) 2004-02-20 2013-10-22 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US20090216320A1 (en) * 2006-04-21 2009-08-27 The Children's Hospital Of Philadelphia Magnetic Gradient Targeting And Sequestering Of Therapeutic Formulations And Therapeutic Systems Thereof
WO2008156904A2 (en) * 2007-04-09 2008-12-24 Children's Medical Center Corporation Systems and methods for nanomagnetic actuation of molecular cell signaling
DE102009004086A1 (en) * 2009-01-05 2010-07-22 Gottfried Wilhelm Leibniz Universität Hannover Electromagnetic microsystem for manipulating magnetic micro- or nanobeads
CN103432688A (en) * 2013-08-24 2013-12-11 仇活连 Reinforced electromagnetic therapeutic apparatus with superimposed magnetic fields
CN113143843B (en) * 2021-03-15 2023-11-28 上海交通大学 Medical nanoparticle fixed-point treatment device and manufacturing method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030083646A1 (en) * 2000-12-22 2003-05-01 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US6603994B2 (en) * 2000-12-28 2003-08-05 Scimed Life Systems, Inc. Apparatus and method for internally inducing a magnetic field in an aneurysm to embolize aneurysm with magnetically-controllable substance
US6626819B2 (en) * 2001-01-12 2003-09-30 Scimed Life Systems, Inc. Permanent magnetic and electromagnetic apparatus for embolizing an aneurysm with magnetically controllable embolic and method
US20030187320A1 (en) * 2002-03-29 2003-10-02 Toby Freyman Magnetically enhanced injection catheter
US6673104B2 (en) * 2001-03-15 2004-01-06 Scimed Life Systems, Inc. Magnetic stent
US6692490B1 (en) * 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
US20040143213A1 (en) * 2002-11-12 2004-07-22 Collegium Pharmaceutical, Inc. Inertial drug delivery system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692490B1 (en) * 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
US20030083646A1 (en) * 2000-12-22 2003-05-01 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US6603994B2 (en) * 2000-12-28 2003-08-05 Scimed Life Systems, Inc. Apparatus and method for internally inducing a magnetic field in an aneurysm to embolize aneurysm with magnetically-controllable substance
US6626819B2 (en) * 2001-01-12 2003-09-30 Scimed Life Systems, Inc. Permanent magnetic and electromagnetic apparatus for embolizing an aneurysm with magnetically controllable embolic and method
US6673104B2 (en) * 2001-03-15 2004-01-06 Scimed Life Systems, Inc. Magnetic stent
US20030187320A1 (en) * 2002-03-29 2003-10-02 Toby Freyman Magnetically enhanced injection catheter
US20040143213A1 (en) * 2002-11-12 2004-07-22 Collegium Pharmaceutical, Inc. Inertial drug delivery system

Also Published As

Publication number Publication date
WO2006039675A2 (en) 2006-04-13

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