WO2006038690A1

WO2006038690A1 - Functional food and drink

Info

Publication number: WO2006038690A1
Application number: PCT/JP2005/018633
Authority: WO
Inventors: Naomi Kuze; Masato Kawaguchi; Taisuke Koike; Isao Horiuchi
Original assignee: Japan Applied Microbiology Research Institute Ltd.
Priority date: 2004-10-07
Filing date: 2005-10-07
Publication date: 2006-04-13
Also published as: JPWO2006038690A1

Abstract

A functional food and drink having been enhanced with respect to the functions such as antibacterial, antioxidant, antiallergic, and antitumor properties and protection against hepatic function disorder. There is provided a food or drink containing red propolis as a raw ingredient, characterized in that the original plant of the red propolis is at least one member selected from among Stryphnodendron adstringens, Schinus molle, Rhizophora mangle and Manikara elata, and that the food or drink has at least one functional activity selected from among antibacterial, antioxidant, antiallergic, and antitumor properties and protection against hepatic function disorder. Accordingly, over those of the conventional propolis, the antibacterial, antioxidant, antiallergic, and antitumor properties and protection against hepatic function disorder have been enhanced.

Description

Specification

Functional food and drink

Technical field

[0001] The present invention particularly relates to a functional food or drink.

Background art

[0002] In recent years, it has become increasingly social to improve the functionality of products of this type, such as antibacterial and anti-acidic properties, from the viewpoint of ensuring safety and maintaining health. The trend is as desired. However, the functionality possessed by this type of product has not yet achieved sufficient efficacy, and further enhancement of functionality is strongly desired.

[0003] Therefore, conventional techniques disclosed in Patent Documents 1 and 2 that respond to such demands have been proposed.

Patent Document 1: JP-A-5-316968

Patent Document 2: JP 2004-159655 A

Disclosure of the invention

Problems to be solved by the invention

[0004] However, these conventional techniques have a drawback that they are not practical because they require complicated and complicated processes for extraction and production.

[0005] An object of the present invention is to provide a functional food or drink that can eliminate such inconveniences.

Means for solving the problem

[0006] The present invention has the following configurations to solve the above problems.

The gist of the invention of claim 1 is a food or drink product containing red propolis as a raw material,

Eyes ij ti red-mouthed hollis is characterized by having at least one of Strypnnodendron aastnngens ^ ¾chinus molie, Rhi zophora mangle, and Manikara elata as origin plant,

The food or drink has antibacterial action, antioxidant action, antiallergic action, antitumor action, or liver function. It exists in the food / beverage products characterized by having one or more functional effects of the protective effect of ability disorder.

The gist of the invention described in claim 2 is that the red propolis has an absorption spectrum maximum in the vicinity of a wavelength of 280 nm in the ultraviolet absorption spectrum, and has a specific power ^ or more with the absorbance in the vicinity of the stable region, and the visible region. 2. The food / beverage according to claim 1, wherein the absorption spectrum has a maximum absorbance near a wavelength of 500 nm and a ratio of the absorbance in the nearby stable region is 5 or more.

The gist of the invention described in claim 3 is an antibacterial agent containing red propolis as an active ingredient,

Ij self-red propolis ί, Stryphnoaendron adstringens ^ ¾chmus molle, Rhi zophora mangle, and Manikara elata

The antibacterial agent resides in an antibacterial agent characterized by being used for food and drink, cosmetics, or pharmaceuticals.

The gist of the invention described in claim 4 is that the red propolis has an absorption spectrum maximum in the vicinity of a wavelength of 280 nm in the ultraviolet absorption spectrum, and has a specific power ^ or more with the absorbance in the vicinity of the stable region, and the visible region. 4. The antibacterial agent according to claim 3, wherein the absorption spectrum has a maximum absorbance near a wavelength of 500 nm and a ratio of the absorbance in the vicinity of the stable region is 5 or more.

The gist of the invention described in claim 5 is an antioxidizing agent containing red propolis as an active ingredient,

The antioxidant is an antioxidant for use in foods and drinks, cosmetics, or pharmaceuticals.

The gist of the invention of claim 6 is that the red propolis has an absorption maximum in the vicinity of a wavelength of 280 nm in the ultraviolet absorption spectrum, and has a specific power with an absorbance in the vicinity of the stable region ^ or more The antioxidant according to claim 5, wherein the antioxidant has a maximum absorbance near a wavelength of 500 nm in the visible absorption spectrum, and the ratio of the absorbance in the nearby stable region is 5 or more. Exist.

The gist of the invention of claim 7 is an anti-allergic agent containing red propolis as an active ingredient,

Eyes li self red propolis ίMA, Stryphnoaendron adstringens, ¾chmus molle, Rhi zophora mangle, and Manikara elata

The antiallergic agent is an antiallergic agent characterized in that it is used for foods and drinks, cosmetics or pharmaceuticals.

The gist of the invention described in claim 8 is that the red propolis has an absorption spectrum maximum in the vicinity of a wavelength of 280 nm in the ultraviolet absorption spectrum, has a specific power ^ or more with the absorbance in the vicinity of the stable region, and is visible. 8. The antiallergic agent according to claim 7, wherein the absorption spectrum has a maximum value of absorbance around a wavelength of 500 nm, and a ratio of the absorbance in the nearby stable region is 5 or more.

The gist of the invention described in claim 9 is an antitumor agent containing red propolis as an active ingredient,

The antitumor agent is an antitumor agent characterized in that it is used for foods and drinks or pharmaceuticals.

The gist of the invention of claim 10 is that the red propolis has an absorption spectrum maximum in the vicinity of a wavelength of 280 nm in the ultraviolet absorption spectrum, has a specific power ^ or more with the absorbance in the vicinity of the stable region, and has a visible region. 10. The antitumor agent according to claim 9, wherein the absorption spectrum has a maximum absorbance near a wavelength of 500 nm and a ratio of the absorbance in the vicinity of the stable region is 5 or more.

The gist of the invention described in claim 11 is that the liver contains red propolis as an active ingredient. A dysfunction protective agent,

Eyes ij ti red propolis ί, Stryphnodendron adstringens, Schinus molle, Rhi zophora mangle, and Manikara elata

The liver dysfunction protective agent is for a liver dysfunction protective agent characterized in that it is used for foods and drinks or pharmaceuticals.

The gist of the invention of claim 12 is that the red propolis has an absorption spectrum at a wavelength near 280 nm in the ultraviolet absorption spectrum, has a specific power ^ or more with the absorbance in the nearby stable region, and is visible. 12. The liver dysfunction protective agent according to claim 11, wherein the absorption spectrum has a maximum absorbance at a wavelength of about 500 nm and a ratio of the absorbance in the vicinity of the stable region is 5 or more. The invention's effect

[0007] According to the present invention, a functional food or drink containing a red propolis derived from a specific plant of origin as a raw material can be easily provided. Therefore, sufficient antibacterial action, antioxidant action, and antiallergic action are provided. In addition, functional foods and drinks having an antitumor action or liver dysfunction protection action can be provided. By taking this food and drink, it becomes possible to improve health.

[0008] Further, since red propolis derived from a plant of a specific origin is contained as an active ingredient, an antibacterial agent, an antioxidant, an antiallergic agent, an antitumor agent, or a liver dysfunction protective agent can be provided. It is possible to provide a safe antibacterial agent, antioxidant, antiallergic agent, antitumor agent, or liver dysfunction protective agent having functionality and excellent practicality.

Brief Description of Drawings

[0009] FIG. 1 is a bar graph showing the anti-acidic ability of various propolises.

FIG. 2 is a graph showing the spectral characteristics (ultraviolet region) of two types of propolis.

FIG. 3 is a graph showing spectral characteristics (visible region) of two types of propolis.

FIG. 4 shows an antibacterial action (MRSA) of an antibacterial agent in Example 3 of the present invention.

FIG. 5 shows an antibacterial action (MSSA) of an antibacterial agent in Example 3 of the present invention.

FIG. 6 shows the antibacterial action (Staphylococcus epidermidis) of the antibacterial agent in Example 3 of the present invention.

FIG. 7 shows the liver dysfunction protective action of the liver dysfunction protective agent in Example 7 of the present invention. FIG. 8 shows the antitumor effect of an antitumor agent in Example 8 of the present invention.

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, embodiments of the present invention will be described with reference to the drawings.

[0011] The functional food and drink, antibacterial agent, antioxidant, antiallergic agent, antitumor agent, and liver dysfunction protective agent according to the present invention contain Brazilian red propolis as an active ingredient. This red propolis is different from normal propolis in that it has a red color. This is the origin of the plant, a strypnnodendron adstrmgens, ¾chmus molie, Rhizopnora m angle, Manikara elata, or multiple species of these. Because it is.

Stryphnodendron adstringens is a special deciduous sub-tree of Brazil that has vascular contraction. Schinus molle is an evergreen Takagi of the Japanese name “Pepper botanus”, and scabbard is used for astringents, wounds, tonics, translucents, diuretics, anti-diarrhea, swelling medicines, etc. Rhizophora mangle is a Japanese name “American hirugi”, a high tree that has astringent and hemostatic properties and is also used for tumors. Manikara elata is an ultra-high tree produced in Brazil and is used for tumor swelling and softening. All of these origin plants have red crusts and are considered to be the origin plant of the red propolis used in the present invention.

In addition, as shown by the solid line graph in FIG. 2, this red propolis has an absorption spectrum maximum in the vicinity of a wavelength of 280 nm (275 to 285 nm) in the ultraviolet absorption spectrum, and has a stable region (wavelength of 320 nm). Spectral characteristics with a ratio of absorbance of (near) to 1 or more. In addition, as shown by the solid line graph in Fig. 3, this red propolis has a maximum absorbance at a wavelength of about 50 Onm (490-510 nm) in the visible absorption spectrum, and a stable region in the vicinity (around a wavelength of 650 nm). ) Shows a spectral characteristic whose ratio to the absorbance is 5 or more. For comparison, the spectral characteristics of Brazilian yellow propolis are shown in phantom lines in Fig. 2. Here, the absorbance means a common logarithm of the reciprocal of the transmittance.

[0013] This red propolis has an excellent antibacterial action, antibacterial action, antioxidant action, antiallergic action, antitumor action, and liver dysfunction protective action not found in conventional propolis. It can be used as functional foods and drinks that are expected to work, and as antibacterial agents, antioxidants, antiallergic agents, antitumor agents, and liver dysfunction protective agents. [0014] When this red propolis is used as the above-mentioned functional food or drink, it may be directly added to the food or drink, or an active ingredient extracted by hot water extraction or solvent extraction is added to the food or drink. You may do it. The active ingredient in the red propolis bulk contains both fat-soluble and water-soluble ingredients, so it is possible to extract both fat-soluble and water-soluble active ingredients such as liquid carbon dioxide extraction. It is preferable to purify by a simple method.

[0015] The antibacterial agent, the antioxidant, and the antiallergic agent can be used for various uses such as food and drink, cosmetics, and pharmaceuticals. Here, food and drink products include processed agricultural products such as vegetable juice and tofu, processed fishery products such as sausages and chikuwa, processed livestock products such as cheese and ham, pickles, Japanese confectionery, Western confectionery, and other livestock feeds. is there. Cosmetics include bathing agents, shampoos, rinses, emulsions, hair creams, lipsticks and toothpastes. In addition, for pharmaceutical use, there are mouthwash, food poisoning, internal medicine for infectious diseases, wound medicine, external salve for burns, nasal spray and the like.

The antitumor agent and hepatic dysfunction protective agent can be used for various uses such as food and drink as described above.

[0016] These antibacterial agents, antioxidant agents, antiallergic agents, antitumor agents, and hepatic dysfunction protective agents have various dosage forms such as powders, granules, tablets, etc., depending on their use and usage. It can be a shape.

Example 1

[0017] In order to evaluate the antibacterial properties of the antibacterial agent according to the present invention, the concentration of the Brazilian red populus was varied in 6 steps within a range of 100 to 5,000 μg / mL. At this time, it was examined how the growth of the test bacteria in the medium changes. For comparison, the same measurement was performed for Cuban red propolis and Brazilian yellow propolis. Specifically, the sample was dissolved in 80% ethanol (EtOH), and the growth was observed after inoculating the test bacteria on pour medium (plate agar medium) of each concentration. The measurement results are summarized in Table 1.

[0018] For Brazilian red propolis, the number of samples is 2 (Brazilian red (1), Brazil red (2)), and for Cuban red propolis, the number of samples is 2 ( Cuban red (1), Cuban red (2)), and for Brazilian yellow propolis, the number of samples is 1 ( Brazil yellow). In addition, Escherichia coli (hereinafter abbreviated as E.coli), Peudomonas aeruginosa (hereinafter abbreviated as P.aerugmosa), Enterococcus faec alis (hereinafter abbreviated as E. faecahs). J, Four types of Staphylococcus aureus (hereinafter abbreviated as S. aureus) were used.

[Table 1] Concentration of propolis in the medium [ag / mL] * ^Lambda sample * Test bacteria 100 250 500 1 000 2, 500 5 000

E.coli 3+ 3+ 2+ + + + Key: Red (1)

P.aeruginosa 3+ 3+ 2+ + + + ϋ. Faecalis

S. aureus

E.coli 3+ 3+ 2+ 2+ 2+ + Kiniva Red (2)

P.aeruginosa 3+ 3+ 3+ 2+ 2+ + h. Faecalis

S. aureus

E.coli 3+ 3+ 2+ +

Nozil Red (1)

P.aeruginosa 3+ 3+ 2+ +

t. faecalis

S. aureus

E.coli 3+ 3+ 2+ +

Matedil red (2)

P.aeruginosa 3+ 3+ 2+ +

. faecalis

S. aureus

E.coli 3+ 3+ 3+ 3+ 3+ 3+ Jill yellow

P.aeruginosa 3+ 3+ 3+ 3+ 3+ 30

E. faecalis 2+ +

S. aureus 2+ +

3+; good colony formation +; weak growth but colony formation

2+; between 1+ and 3+

Soil: Insufficient colony formation, but slightly growing

; It is all not observed at all the growth * _C ontrol is 3+

* Cuban red; Cuban red propolis

Brazilian red; Brazilian red mouth police

Brazil yellow; Provolis from Minas, Brazil

* * Samples were dissolved in 80% EtOH and pour medium was prepared at each concentration. Based on the results in Table 1, the minimum concentration that inhibits the growth of the test bacteria in each sample, that is, the minimum inhibitory concentration (MIC). Asked. The results are summarized in Table 2. The lower the minimum inhibitory concentration (MIC), the stronger the antibacterial effect of the sample. Show.

[0021] [Table 2]

Unit: g / mL Test Bacteria Brazil Yellow:, Rasil Red (1) Brady Red (2) Yellow Red (1) Yellow Red (2)

E.coh 2, 500 2, 500

― * ―

P.aeruginosa 2, 500 2, 500 — *

E. faecalis 1,000 100 or less 100 or less 100 or less 250

S. aureus 500 100 or less 100 or less 100 or less 100 or less

* No growth inhibition in 5,000 μg / mL thick skin

[0022] As is apparent from Table 2, it was found that the antibacterial action was the strongest for Brazilian red propolis, followed by Cuban red propolis, and Brazilian yellow propolis was the weakest.

Example 2

[0023] In the same manner as in Example 1, the experiment was carried out with the propolis concentration varied in the range of 40 3000 μg ZmL, and the minimum growth inhibitory concentrations of various test bacteria were calculated. There are five types of test bacteria: E. coli P. aeruginosa ^ S. aureus ^ Bacillus subtillis (abbreviated as ^ λ F B. subtillis) and Candid a albicanc (hereinafter abbreviated as C. albicanc). Was used. The results are shown in Table 3.

[0024] [Table 3] Unit: U g / mL Test bacteria Brazil yellow Brazil red (1) Brazil red (2) Cuba red (1)

E.coli> 3000 2500> 3000> 3000

P.aeruginose> 3000 2500> 3000> 3000

S. aureus 500 40 80 80

B. subtil lis 2500 500 500 500

C. albicanc 500 80 80 80

[0025] That is, for the two types of E. coli and P. aeruginosa test strains, the minimum growth inhibitory concentration (MIC) of 5,000 μg ZmL for Cuban red propolis and Brazilian propolis is 5,000 μg ZmL. The Brazilian red propolis had a minimum growth inhibitory concentration (MIC) of 2,500 μgZmL, whereas the growth inhibition was not observed even at 5,000 μgZmL. [0026] As for E. faecalis, the minimum growth inhibitory concentration (MIC) of Brazilian yellow propolis is 1,000 μgZmL, while that of Brazilian red propolis is the minimum growth inhibitory concentration ( MIC) dropped significantly to below 100 μgZmL.

For S. aureus, Brazilian yellow propolis has a minimum inhibitory concentration (MIC) of 500 μgZmL, while Brazilian red propolis has a minimum inhibitory concentration (MIC) of 40 to 80 μm. It was significantly lower than gZmL.

For B. subtillis, Brazilian yellow propolis has a minimum inhibitory concentration (Ml C) of 2500 μgZmL, while Brazilian red propolis has a minimum inhibitory concentration (MIC) of 500 μgZmL. And decreased significantly.

For C. albicanc, Brazilian yellow propolis has a minimum inhibitory concentration (Ml C) of 500 μgZmL, while Brazilian red propolis has a minimum inhibitory concentration (MIC) of 80 μg. It was significantly reduced to gZmL.

[0027] And for Brazilian red propolis! If the concentration is 500 μgZmL or more, the antibacterial activity is improved against all 6 types of test bacteria, If the value is 1,000 g ZmL or more and 2,500 gZmL or more, the tendency becomes remarkable. Therefore, the optimal concentration of red propolis produced in Brazil is 100 gZmL or more when using E. faecalis, S. aureus, and C. albicanc from the viewpoint of antibacterial properties. When used for seeds, it is 500 gZmL or more (preferably 1,000 / z gZmL or more, more preferably 2,500 μgZmL or more).

Example 3

[0028] The antimicrobial action of red propolis was tested using test bacteria other than those described above.

Examples of the test bacteria include Methicillin Resistant Staphylococcus aureus (methicillin metastatic Staphylococcus aureus, hereinafter abbreviated as MRSA), Methicillin Sensitive Staphylococcus aureus (methicillin-sensitive Staphylococcus aureus, hereinafter abbreviated as MSSA), Three types of Staphylococcus epider midis (Staphylococcus epidermidis) were used. We examined how the growth of the test bacteria in the medium changes when the Brazilian red propolis content is changed to 200 gZmL and 20 gZmL. For comparison, the same measurement was performed for Brazilian yellow propolis. Specifically, the sample extracted with liquid carbon dioxide gas is 80% ethanol (EtOH). After inoculating the test bacteria in pour medium (plate agar medium) of each concentration, the growth state was observed. The measurement results are shown in Figs.

[0029] As shown in Figs. 4 to 6, in any of the test bacteria, the red propolis administration group showed a growth inhibition rate of 80% or more at 200 gZmL. This effect was higher than that of conventional propolis.

Example 4

[0030] In order to evaluate the antioxidant properties of the antioxidants according to the present invention, the antioxidant properties were measured using DPPH radical scavenging ability mainly measuring fat-soluble substances. For Brazilian red propolis, the number of samples is 2 (Brazilian red (1), Brazilian red (2)), and for Cuban red propolis, the number of samples is 2 (Cuban red (1), Cuban red (2)) and for Brazilian yellow propolis, the number of samples is 1 (Brazilian yellow)

[0031] The results are shown graphically in FIG. In the graph of FIG. 1, “1” on the vertical axis means a value that erases 50% of ImM DPPH at a sample concentration of lmgZlOOmL. As can be seen from the graph in FIG. 1, it was found that the antioxidant capacity was highest for Brazilian red propolis, followed by Brazilian yellow propolis, and Cuba red propolis being the lowest. Example 5

[0032] In the same manner as in Example 3, the DPPH radical scavenging ability and the SOD-like activity measurement were used to measure the antioxidant activity. DPPH radical scavenging activity shows relatively lipid-soluble anti-acid activity due to extraction with ethanol, and SOD-like activity is water-soluble anti-acid activity due to extraction with water It is thought that it shows. As a sample, an original mass of propolis, a liquid carbon dioxide extracted from this, and a water extracted one were used. The results are shown in Table 4.

[0033] [Table 4] Sample recovery rate DPPH radical scavenging ability SOD-like activity

(%) UNIT (mg / mL) (total activity) Nitrite unit / g (total activity) Raw mass (100) 1.01 1.01 350.80 350.80 Brazilian red (1) Liquefied carbon dioxide extraction 40 1.82 0.73 1 39.03 55.61

Water extraction 12 0.03 0.00 1491.06 1 78.92 Bulk (100) 0.73 0.73 243.61 243.61 Brazil yellow Liquefied carbon dioxide extraction 35 1.76 0.61 507.65 1 77.68

Water extraction 12 1.20 0.14 2063.52 247.62 [0034] As shown in Table 4, red propolis was found to have higher anti-oxidative activity in both the fat-soluble state and water-soluble state than the conventional propolis in the original state. In addition, DPPH radical scavenging activity was found to be higher in red propolis, and DPPH radical scavenging activity was found to increase by about 1.5 times by extraction with liquid sodium carbonate gas.

Example 6

[0035] In order to evaluate the antiallergic activity of the antiallergic agent according to the present invention, antiallergic ability was measured using whole anaphylactic shock-induced mice. To induce systemic anaphylactic shock, mice were administered compound48 / 80. As for propolis, a water-extracted powder extracted with hot bulk water was used for oral administration to mice. As a control, a control that was given water instead of propolis was used as a control. The results are shown in Table 5.

[0036] [Table 5] Survival rate (%)

Sample i _e 20 i ₂ 60

Control 0 0

As shown in Table 5, the Control group was annihilated 20 minutes after induction of anaphylactic shock, whereas the Propolis administration group was completely annihilated. It was also found that red propolis showed a higher survival rate than conventional propolis, and the higher the sample concentration, the higher the survival rate. Example 7

[0038] In order to evaluate the liver dysfunction protective action of the liver dysfunction protective agent according to the present invention, the liver dysfunction protective action was measured using experimental hepatopathy-induced rats. Rats were administered tetrasalt carbon dioxide to induce experimental liver injury.

Six-week-old Wistar male rats were grouped so that their body weights were equalized after one week of preliminary breeding, and were divided into control group, yellow propolis group, and red propolis group (n = 8). In the oral police administration group, yellow and red propolis hot water extracts were administered by oral gavage daily for 8 days using a metal gastric sonde at a dose of 200 mgZkgZday. In the control group, 1 ml of purified water was administered. After the final administration, the animals were fasted for 12 hours or longer, 0.05 ml CC14 / 0.2 ml olive oil per 100 g body weight was orally administered, and serum GPT and GOT were measured 24 hours later. The results are shown in FIG.

[0039] The GPT value was 549 in the order of control, yellow propolis, and red propolis, respectively.

± 216 (mean SD; the same applies hereinafter), 471 ± 160, 307 ± 59 IU / L.

Assuming that the GOT value and GPT value of these control groups are 100%, the GOT value was suppressed by 31.9% in the conventional yellow propolis administration group and 44.6% in the red propolis administration group. Regarding the value, 18.4% of suppression was observed in the yellow propolis administration group and 46.9% suppression in the red propolis administration group. In particular, the red propolis administration group was significantly lower than the control group (P 0.05). From this, it was shown that the red propolis used in the present invention has a stronger liver dysfunction protective effect than the conventional yellow propolis. Example 8

[0040] In order to evaluate the antitumor activity of the antitumor agent according to the present invention, the inbred mouse C57BLZ6N, female, and 6 weeks of age tested were preliminarily raised for one week, and the average body weight of each group was one. Six groups were composed of 10 animals per group. As samples, prepare control (purified water), propolis A of other companies' propolis products (manufacturing: Kyowa Hakko Kogyo Co., Ltd., sales: San Hells Co., Ltd.), and red propolis hot water extract of the present invention. Prepare a mouse body weight of 800 mg / kg and administer once a day using an oral sonde. Started. On day 8 of administration (dayO), EL-4 (mouse lymphoma) was inoculated subcutaneously at a ratio of 1.5 X 104 cells / 0.2 mlZhead on the back of the lumbar region. The sample administration was continued and the tumor volume (major axis X minor axis) was measured. On dayl7, each mouse was sacrificed by cervical dislocation, and then the spleen, thymus and tumor were removed and weighed. The results are shown in Table 6 and Fig. 8.

[0041] [Table 6]

[0042] As shown in Table 6 and Fig. 8, compared to the control group, the tumor growth inhibitory effect was 12.1% for the other company's product and 54.7% for the red propolis hot water extract of the present invention. It was observed . Thus, it has been found that the red propolis-derived antitumor agent of the present invention can be expected to have a high antitumor effect.

Industrial applicability

[0043] The functional food or drink product containing the red propolis of the present invention as a raw material has a sufficient antibacterial action, antioxidant action, antiallergic action, antitumor action, or liver dysfunction protective action. Food and drink can be provided relatively easily. Taking these foods and drinks can improve your health.

[0044] Further, since red propolis derived from a plant of a specific origin is contained as an active ingredient, an antibacterial agent, an antioxidant, an antiallergic agent, an antitumor agent, or a liver dysfunction protective agent can be provided. It is possible to provide a safe antibacterial agent, antioxidant, antiallergic agent, antitumor agent, or liver dysfunction protective agent that has functionality and is excellent in safety and practicality.

Claims

The scope of the claims

[1] A food or drink containing red propolis as a raw material,

The food or drink has one or more functional actions of antibacterial action, antioxidant action, antiallergic action, antitumor action, or liver dysfunction protecting action.

[2] The red propolis has an absorption spectrum at a wavelength around 280 nm in the ultraviolet absorption spectrum, a ratio of the absorbance in the vicinity of the stable region is 1 or more, and a visible absorption spectrum. 2. The food or drink according to claim 1, wherein the food or drink has a maximum absorbance in the vicinity of a wavelength of 500 nm and a ratio of the absorbance in the vicinity of the stable region is 5 or more.

[3] An antibacterial agent containing red propolis as an active ingredient,

The antibacterial agent is for foods and drinks, cosmetics or pharmaceuticals

[4] The red propolis has an absorption spectrum at a wavelength near 280 nm in the ultraviolet absorption spectrum, a ratio of 1 or more to the absorbance in the nearby stable region, and a visible absorption spectrum. 4. The antibacterial agent according to claim 3, wherein the antibacterial agent has a maximum value of absorbance near a wavelength of 500 nm and a ratio of the absorbance in the vicinity of the stable region is 5 or more.

[5] An antioxidant containing red propolis as an active ingredient,

Antioxidant _Q characterized in that the antioxidant is for food and drink, cosmetics or pharmaceuticals.

[6] The red propolis has an absorption spectrum at a wavelength near 280 nm in the ultraviolet absorption spectrum, a ratio of the absorbance in the vicinity of the stable region is 1 or more, and a visible absorption spectrum. 6. The antioxidant according to claim 5, wherein the antioxidant has a maximum absorbance near a wavelength of 500 nm and has a ratio of 5 or more to the absorbance in the nearby stable region.

[7] An anti-allergic agent containing red propolis as an active ingredient,

The antiallergic agent is characterized in that the antiallergic agent is for foods and drinks, cosmetics or pharmaceuticals.

[8] The red propolis has an absorption spectrum at a wavelength near 280 nm in the ultraviolet absorption spectrum, a ratio of the absorbance in the vicinity of the stable region is 1 or more, and a visible absorption spectrum. 8. The antiallergic agent according to claim 7, wherein the antiallergic agent has a maximum absorbance in the vicinity of a wavelength of 500 nm and a ratio of the absorbance in the vicinity of the stable region is 5 or more.

[9] An antitumor agent comprising red propolis as an active ingredient,

The antitumor agent is for food or drink or for pharmaceuticals.

[10] The red propolis has an absorption spectrum at a wavelength near 280 nm in the ultraviolet absorption spectrum, a ratio of the absorbance in the vicinity of the stable region is 1 or more, and a visible absorption spectrum. 10. The antitumor agent according to claim 9, wherein the antitumor agent has a maximum absorbance in the vicinity of a wavelength of 500 nm and a ratio of the absorbance in the vicinity of the stable region is 5 or more.

[11] A liver dysfunction protective agent containing red propolis as an active ingredient,

The liver function disorder protective agent is for food and drink or for pharmaceuticals Obstacle protectant.

The red propolis has a maximum absorbance at a wavelength of about 280 nm in the ultraviolet absorption spectrum, a ratio of 1 or more to the absorbance in the nearby stable region, and a visible absorption spectrum at a wavelength of 500 nm. 12. The liver dysfunction protective agent according to claim 11, which has a local maximum absorbance and has a ratio of 5 or more to the absorbance in the nearby stable region.