WO2006038386A1 - Probe for detecting radioactive isotope and method for detecting radioactive isotope - Google Patents

Probe for detecting radioactive isotope and method for detecting radioactive isotope Download PDF

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Publication number
WO2006038386A1
WO2006038386A1 PCT/JP2005/015094 JP2005015094W WO2006038386A1 WO 2006038386 A1 WO2006038386 A1 WO 2006038386A1 JP 2005015094 W JP2005015094 W JP 2005015094W WO 2006038386 A1 WO2006038386 A1 WO 2006038386A1
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WO
WIPO (PCT)
Prior art keywords
radioisotope
radiation image
detection probe
subject
light shielding
Prior art date
Application number
PCT/JP2005/015094
Other languages
French (fr)
Japanese (ja)
Inventor
Kunihide Nishizawa
Takuya Sase
Shigeki Ito
Original Assignee
National University Corporation Nagoya University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by National University Corporation Nagoya University filed Critical National University Corporation Nagoya University
Priority to JP2006539183A priority Critical patent/JP4882070B2/en
Publication of WO2006038386A1 publication Critical patent/WO2006038386A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/40Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/4057Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis by using radiation sources located in the interior of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4216Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using storage phosphor screens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/425Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using detectors specially adapted to be used in the interior of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4258Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation

Definitions

  • the present invention relates to a radioisotope detection probe and a radioisotope detection method.
  • Radioisotopes are widely used in research, education, industry, medicine, and the like.
  • radioactive iodine when used, the ingested radioactive iodine accumulates in the thyroid gland and causes the thyroid gland to be exposed.
  • Patent Document 1 Japanese Patent Laid-Open No. 7-333344
  • the radiation image conversion plate is a two-dimensional radiation detection medium that replaces the X-ray film, and is used in a system combined with a dedicated image analyzer.
  • the present invention has been made in view of the above circumstances, and includes a radiation image conversion plate containing a photostimulable phosphor, a radioisotope detection probe for obtaining a clear image with high sensitivity, and a radioisotope
  • An object is to provide a detection method.
  • the invention of claim 1 is a radioisotope detection probe for obtaining a radiographic image of a radioisotope existing in a predetermined organ of a subject.
  • a fixture that can be fixed to a predetermined part of the subject, a light-shielding bag that is supported and fixed to the fixture and shields visible light, and is inserted into the light-shielding bag and contains a stimulable phosphor.
  • a radioisotope detection probe comprising a radiation image conversion plate.
  • the invention of claim 2 is the invention of claim 1, wherein the surface of the light shielding bag facing the predetermined portion is on the surface of the radiation image conversion plate. It is characterized by a lead-containing collimator provided with a plurality of through holes penetrating in the intersecting direction.
  • the invention of claim 3 is the invention of claim 1, characterized in that the side of the light shielding bag facing the predetermined portion is covered with a cushioning material. .
  • the invention according to claim 4 is the invention according to claim 2 or claim 3, wherein the side of the collimator facing the predetermined portion is covered with a cushioning material. It is characterized by that.
  • the invention of claim 5 is the apparatus of any one of claims 1 to 4, wherein the light shielding bag is configured to be detachable from the fixture. It is characterized by this.
  • the invention of claim 6 is a radioisotope detection method for obtaining a radioisotope radiation image present in a predetermined organ of a subject, and a radiographic image containing a stimulable phosphor
  • a latent image forming step of forming a latent image on the radiation image conversion plate and an analyzing step of analyzing the formed latent image to obtain the radiation image are characterized.
  • the probe for detecting a radioisotope of the invention of the present invention is used as follows. That is, first, a fixture having a light-shielding bag into which a radiation image conversion plate is inserted is supported and fixed to a predetermined part (eg, neck) of a subject. In this state, when waiting for a predetermined time to elapse, a latent image is formed on the radiation image conversion plate. After the latent image is formed, the radiation image conversion plate is taken out from the light shielding bag in the dark room, and an image is obtained by a dedicated image analysis device.
  • a predetermined part eg, neck
  • the radioisotope detection probe of the present invention is fixed to a predetermined part of the human body while the latent image is formed.
  • the relative position of the part does not change, and as a result, the image is not blurred and a clear image is obtained.
  • the radiation image conversion plate is placed in a light shielding bag, the formed latent image is not erased by visible light.
  • the lead-containing collimator provided with a plurality of through holes penetrating in the direction intersecting the plane of the radiation image conversion plate is provided, the radiation in this direction is selective. And the resolution of the latent image formed on the radiation image conversion plate is improved.
  • the side of the fixture facing the predetermined part is covered with the cushioning material, so there is no risk of damaging the predetermined part with the fixture.
  • the light shielding bag is configured to be detachable from the fixture. It is convenient to carry it by removing the light shielding bag with the radiation image conversion plate inserted and carrying it to the darkroom for analysis.
  • FIG. 1 is a plan view of a radioisotope detection probe according to a first embodiment.
  • Fig. 2 is a cross-sectional view of the probe for detecting a radioisotope (A-A cross-sectional view of Fig. 1).
  • FIG. 3 is an exploded plan view of a probe for detecting radioisotopes.
  • FIG. 4 is a perspective view of the radiation image forming unit as seen from the front side and a perspective view from the back side.
  • FIG. 5 is a perspective view showing a light shielding bag and a radiation image conversion plate.
  • Fig. 6 is a perspective view showing a state in which a radioactive isotope detection probe is attached to the neck.
  • FIG. 7 is a perspective view of the radioactive isotope detection probe of the second embodiment.
  • FIG. 8 is a cross-sectional view of FIG.
  • FIG. 9 is an exploded perspective view of a radioactive isotope detection probe.
  • FIG. 10 is a plan view of the collimator ((A); collimator A, (B); collimator B, (C) collimator C).
  • FIG. 11 is a perspective view showing a state in which a radioactive isotope detection probe is attached to the neck.
  • FIG. 12 is a schematic perspective view of a neck-thyroid model in the example.
  • FIG.13 Figure 13 shows images when using each radioisotope detection probe ((A); using radioisotope detection probe A, (B); using radioisotope detection probe B, (C): When using radioisotope detection probe C, (D): When using radioisotope detection probe D).
  • FIG. 14 is a perspective view of a radioisotope detection probe of a third embodiment.
  • FIG. 15 is a partially enlarged perspective view showing a state in which the radiation image converting plate breastplate portion housed in the light shielding bag is housed.
  • FIG. 16 shows a radioisotope detection probe mounted on the body of a subject.
  • the radioactive isotope detection probe 1 of this embodiment is for accumulating in a subject's thyroid gland (corresponding to a predetermined organ) to obtain radiation images of V, 12 and 131 1.
  • This radioisotope detection probe 1 is formed in a curved belt shape as a whole, and has a fixture 5 configured to be fixed to the neck 3 by being wound around the neck 3 (corresponding to a predetermined site) of the subject.
  • the radiographic image forming unit 7 is detachably mounted near the center of the fixture 5.
  • the fixture 5 is made of a soft synthetic resin such as a foamed urethane resin having a curved band as a whole, and corresponds to the length of the neck 3 wound around the neck 3 and the length of the neck 3. Width.
  • a band 9 having a hook and loop fastener 9A is attached to one end of the fixture 5, and a hook and loop fastener 11 that can be engaged with the hook and loop fastener 9A of the band 9 is attached near the other end of the fixture 5. It is The fastener 5 is fixed to the neck 3 by engaging the fasteners 9A and 11 on the surface in a state of being wound around the neck 3.
  • the radiation image forming unit 7 has a curved belt shape as a whole, is approximately 1Z3 in length of the fixture 5, and is approximately the same width as the fixture 5.
  • a hook-and-loop fastener 7A is provided at this location, and the hook-and-loop fastener 7A is engaged with and fixed to the hook-and-loop fastener 5A provided on the surface of the fixture 5.
  • the radiation image forming unit 7 includes a light shielding bag 15 for blocking visible light from a radiation image conversion plate 13 containing a stimulable phosphor as shown in FIG. As shown in FIG. 4, a light shielding bag 15 is further inserted into a cloth bag 17 (corresponding to the cushioning material of the present invention).
  • the radiation image conversion plate 13 for example, a product name: Imaging Plate manufactured by Fuji Photo Film Co., Ltd. can be used.
  • the light shielding bag 15 is for preventing the latent image formed on the radiation image conversion plate 13 from being erased by visible light.
  • the light shielding bag 15 having a material strength obtained by laminating aluminum on polyethylene is used.
  • the cloth bag 17 preferably has a soft material on the surface so that the skin of the neck 3 of the subject is not damaged.
  • the radiation image conversion plate 13 containing the stimulable phosphor is inserted into the light shielding bag 15, and the light shielding bag 15 is further inserted into the cloth bag 17 to form the radiation image forming unit 7.
  • the radiographic image forming unit 7 is attached to the fixture 5 to form a radioisotope detection probe 1, and the radioisotope detection probe 1 faces the throat side of the neck 3 of the subject. In this way, fix it to the neck 3 (see Fig. 6). In this way, the thyroid gland and the radiation image conversion plate 13 face each other, and a latent image is formed on the radiation image conversion plate 13.
  • the radioisotope detection probe 1 is removed from the neck 3, and the radiation image forming unit 7 is removed from the radioisotope detection probe 1.
  • the light shielding bag 15 taken out from the radiation image forming unit 7 or the radiation image forming unit 7 is carried into the dark room, the radiation image conversion plate 13 is taken out, and the image is captured by a dedicated image analyzer (for example, BAS-2500 Fuji Photo Film). Get a statue.
  • the radioisotope detection probe 1 of the present embodiment while forming a latent image, the radioisotope detection probe 1 is fixed to the neck 3 of the subject body. And the relative position of the radiation image conversion plate 13 do not change, and as a result, the image is not blurred and a clear image is obtained. [0028] In addition, the radiation image forming unit 7 and the neck 3 can be brought into a close contact state, and the distance between the radiation image conversion plate 13 and the thyroid gland is reduced, so that the sensitivity is improved.
  • the radiation image forming unit 7 and the light shielding bag 15 are detachable from the radioisotope detection probe 1, the radiation image forming unit It is convenient to carry 7 or the light shielding bag 15 in the dark room and analyze it.
  • FIGS. A second embodiment of the present invention will be described with reference to FIGS. Note that the same components as those in the first embodiment are denoted by the same reference numerals, and description of the structure, operation, and effect is omitted.
  • the second embodiment is different from the first embodiment mainly in that the structure of the fixture 5 and the collimator 21 are provided.
  • radioisotope detector probe 1 of this embodiment is for obtaining a radiation image of the Ru 12 and m i.
  • This radioisotope detection probe 1 is formed in a portal cross-sectional shape as a whole as shown in FIGS. 7 to 9, and is fitted over the neck 3 of a subject lying on his / her back on a bed. It can be fixed to 3 (see Fig. 11).
  • the fixture 5 includes a substantially rectangular frame-shaped upper surface wall 23 having an opening in the center, and a pair of side pieces 25 that extend downward on both the left and right ends of the upper surface wall 23.
  • the lid portion 27 that covers the opening of the upper wall 23 forms a gate shape as a whole.
  • the leg portion 25A is screwed into a screw hole 25B whose upper end is threaded upward from the lower end surface of the side piece 25.
  • the leg portion 25A By turning the leg portion 25A clockwise or counterclockwise, the top wall 23 is displaced in the vertical direction. In this way, the height of the top wall 23 can be adjusted according to the height of the subject's neck.
  • a collimator 21 and a light shielding bag 15 into which a radiation image conversion plate 13 containing a stimulable phosphor is inserted are arranged almost horizontally.
  • the collimator 21 and the light shielding bag 15 are crimped while the top wall 23 and the lid 27 Sandwiched between.
  • the lower surface of the collimator 21 is also exposed to the opening force.
  • a cushioning material 29 covered with a soft cloth and a cloth 29B is disposed around an elastic resin 29A such as a polyurethane sponge.
  • the collimator 21 has a lead plate shape as a whole, and is provided with a plurality of through holes 31 penetrating in a direction intersecting the surface of the radiation image conversion plate 13.
  • the collimator 21 is, for example, a lead cylindrical tube having a height of 10 mm, a wall thickness of 0.14 mm, and an inner diameter of 3 mm arranged in a hermetic manner and interconnected.
  • the collimator 21 is, for example, a lead cylindrical tube having a height of 10 mm, a wall thickness of 0.14 mm, and an inner diameter of 3 mm arranged in a hermetic manner and interconnected.
  • the collimator 21 since the collimator 21 is provided, the radiation in the direction of the through hole 31 selectively passes and the resolution of the image formed on the radiation image conversion plate 13 is improved. To do.
  • the radioisotope detection probe 1 of the present embodiment is used in close contact with the human neck 3, so that the distance between the radiation image conversion plate 13 and the thyroid gland is close, so that the sensitivity is good.
  • the radioisotope detection probe 1 is separable from the image analysis apparatus and is small and lightweight, so that the subject's hospital room and Then, after transporting only the radioisotope detection probe 1 to the home of the subject at home and forming a latent image, the radioisotope detection probe 1 may be taken back to the laboratory and analyzed by an image analyzer. Therefore, it is possible to remarkably reduce the burden of these patients, which is not necessary for serious patients and elderly people to go to the examination room.
  • an imaging plate (medical IP; ST-III, Fuji Photo Film) was cut into 110 mm X 200 mm and used.
  • the imaging plate erased the afterimage using an eraser for 30 minutes immediately before use.
  • the imaging plate was inserted into the light shielding bag 15 to prevent the latent image from being erased by white light (visible light). Then, the radioisotope detection probe A shown in FIG.
  • Radioisotope detection probe B was prepared in the same manner as radioisotope detection probe A, except that collimator B was used.
  • a radioactive isotope detection probe C was prepared in the same manner as the radioactive isotope detection probe A except that the collimator C was used.
  • a radioisotope detection probe D was prepared in the same manner as radioisotope detection probe A, except that no collimator was used.
  • Radioisotope detection probes A to D were set on the neck-thyroid model 36 shown in FIG.
  • This neck-thyroid model 36 consists of a model 37 equipped with a 20-ml hollow human thyroid model 33 (manufactured by Kyoto Kagaku; 1. 8 mm-thick methacrylic resin) and a cylindrical shape with an upper and lower bottom that surrounds this model 37.
  • Neck model 41 0.5mm thick methacrylic resin
  • the human thyroid model 33 is filled with 123 I IMBq in total, and the neck model 41 is filled with water.
  • the irradiation time is 10 minutes, and the imaging plate after irradiation is image analysis equipment (BAS-250 0 Fuji Photo Film), personal computer (Power Mac 8500/180, Apple Computer), measurement software (Image Reader ver.3.30 Fuji Photo Film), analysis software (Image Gauge ver.3.30 Fuji Photo Film).
  • the reading sensitivity of the image analyzer was set to S1000.
  • FIG. (A) is when using radioisotope detection probe A
  • (B) is when using radioisotope detection probe B
  • (C) is when using radioisotope detection probe C
  • (D) is It is an image when the probe D for detecting a radioisotope is used.
  • the radioisotope detection probes A to C were used, the image resolution was higher than when the radioisotope detection probe D without a collimator was used, and the shape of the human thyroid model 33 was clearly observed. .
  • the radioisotope detection probe 50 of this embodiment is an organ (such as the lung, liver, gastrointestinal tract, bone marrow, etc.) present in the body B of subject S (corresponding to a predetermined site of the present invention). This is to obtain a radiographic image of the radioisotope accumulated in the corresponding).
  • organ such as the lung, liver, gastrointestinal tract, bone marrow, etc.
  • the radioisotope detection probe 50 of the present embodiment includes an apron 51 (corresponding to the fixture of the present invention) attached to the body B of the subject S, and a light shield attached to the apron 51.
  • a bag 59 and a radiation image conversion plate 58 are provided (see FIG. 14).
  • the apron 51 includes a breast pad 52 (corresponding to the cushioning material of the present invention) that is addressed to the chest side in the body B of the subject S, and a back pad 53 (also of the present invention) that is addressed to the back side. Corresponding to cushioning material).
  • the breast pad portion 52 is formed in a rectangular bag shape with a cloth such as cotton, and the size of the chest pad portion 52 is set to be able to cover almost the entire chest of the subject S.
  • a long surface fastener 52B is attached to the inside of the opening portion 52A along the opening edge so that the mouth of the bag can be opened and closed.
  • the back pad 53 is formed in a rectangular bag shape that is substantially the same shape as the breast pad 52, and its opening 53A can be similarly opened and closed by a surface fastener 53B.
  • the breast pad portion 52 and the back pad portion 53 are attached to the subject S with the openings 52A and 53A facing down, respectively.
  • One end of a pair of shoulder straps 54 is connected to the upper edge of the breast pad 52 (the edge on the side facing the opening edge) slightly outside the center in the left-right direction.
  • the other end of the shoulder strap 54 is connected to a position slightly outside the center in the left-right direction at the upper edge of the back pad 53 (the edge on the side facing the opening edge).
  • the interval between the pair of shoulder straps 54 is an interval through which the head and neck of the subject S can pass.
  • These shoulder straps 54 are equipped with an agitator 55 so that the length can be adjusted freely! /
  • the belt portions 56 are each extended outward in the width direction.
  • a loop tape 57A of a hook-and-loop fastener 57 is attached almost entirely to the surface which is the inner side (the side facing the body portion B of the subject S) when the subject S wears it.
  • hook tape 57B which is paired with loop tape 57A in hook-and-loop fastener 57, is attached to breast pad 52 at the left and right end positions at the lower end position of the outer surface when subject S wears! / RU With this surface fastener 57, the band 56 can be fixed to the breast pad 52 at an arbitrary position in the extending direction.
  • a radiation image conversion plate 58 housed in the light shielding bag 59 is housed inside the breast pad portion 52 and the back pad portion 53.
  • the radiation image conversion plate 58 contains a stimulable phosphor as in the above embodiment, and for example, trade name: Imaging Plate manufactured by Fuji Photo Film Co., Ltd. can be used.
  • As the light shielding bag 59 as long as it can prevent the latent image formed on the radiation image conversion plate 58 from being erased by blocking visible light, as in the above-described embodiment, for example, aluminum is used for polyethylene. Laminated materials can be used.
  • the radiation image conversion plate 58 housed in the light shielding bag 59 is attached to the breast pad 52 and the apron 51. It is accommodated in the back pad 53 and the openings 52A and 53A are closed (see FIG. 15).
  • the apron 51 is attached to the body B of the subject S (see FIG. 16).
  • the subject's S neck is passed between a pair of shoulder straps 54, and the chest rest 52 is suspended from the shoulder so that the chest rest 52 is placed on the subject's S chest and the back rest 53 is placed on the back.
  • the height of chest support 52 and back support 53 matches the position to be inspected on the chest and back by operating Ajista 55.
  • the band 56 is wrapped around the chest side while the chest pad 5 is firmly attached to the chest of the subject S and the back pad 53 is tightly attached to the back of the subject S.
  • the loop tape 57A is attached to almost the entire inner surface of the belt portion 56. Therefore, the amount of winding of the belt portion 56 is adjusted according to the physique of the subject S, and the extension of the belt portion 56 is performed. It can be secured to the hook tape 57B on the breast pad 52 side at an appropriate position in the direction.
  • the apron 51 is fixed in a state where the chest rest 52 is placed on the chest of the subject S and the back rest 53 is placed in close contact with the back.
  • the height of the chest pad part 52 and the back pad part 53 may be adjusted so as to match the abdomen and waist part by operating the adjuster 55. Good.
  • a latent image is formed on the radiation image conversion plate 58.
  • the subject S can change his / her posture freely within a range without changing the relative position of the chest pad 52 and the back pad 53 with respect to the body B of the subject S. It is also possible to do difficult work.
  • the apron 51 is removed from the body B of the subject S, and the light shielding bag 59 containing the radiation image conversion plate 58 is removed from the breast pad 52 and the back pad 53. Then, the light shielding bag 59 is carried into the dark room, the radiation image conversion plate 58 is taken out, and analyzed by a dedicated image analysis device (for example, BAS-2500 Fuji Photo Film). If subject S has ingested radioactive materials such as 6G Co, 13 7 Cs, etc., and these radioactive materials have accumulated in each organ in the body, the organs accumulated by the radiation generated by these radioactive materials An image corresponding to the position and the accumulation amount is obtained.
  • a dedicated image analysis device for example, BAS-2500 Fuji Photo Film
  • the radioisotope detection probe 50 is fixed substantially in close contact with the chest and back of the subject S while forming a latent image! Therefore, the relative positions of the radiation image conversion plate 58 and the chest and back do not change, and as a result, the image is not blurred and a clear image is obtained.
  • the subject S who does not need a large-scale device as in the case of using a conventional whole body counter is not restrained for a long time, so for example, a simple inspection of the presence or absence of internal exposure of a worker working at a nuclear power facility.
  • collimator 21 may be used in the same manner as in the second embodiment.
  • the collimator 21 is exemplified by the one in which the predetermined pipes are arranged in the form of a heart cam.
  • the shape and size of the pipes forming the collimator 21 are not particularly limited.
  • the present invention is not limited to the collimator 21 in which the tubes are assembled, and a plurality of through holes 31 may be formed in a lead-containing plate.
  • the material of the collimator 21 is not limited to lead, and metals other than lead can also be used.
  • a breast, heart, sentinel lymph node, wrist joint, and other various organs may be used.
  • the predetermined part may be, for example, an extremity, a head, or the like other than those exemplified in the above embodiment.
  • the radioisotope detection probe of the present invention may be used to obtain an image of a radioisotope that emits.
  • the chest pad part 52 and the back pad part 53 are attached to the subject S with the openings 52A and 53A on the lower side, but they may be attached with the opening part facing up or sideways. Yes.
  • the side to which the belt portion 56 is attached is the back pad portion 53, but the side to which the belt portion is attached may be the breast pad portion.

Abstract

A probe (1) for detecting radioactive isotope being used to obtain the radiation images of 123I and 131I accumulated at the thyroid gland (predetermined organ) of a subject S. The probe (1) for detecting radioactive isotope comprises a fastening band (5) arranged to be fixed to the neck (3), by being wound around the neck (predetermined part) of the subject S, and a radiation image forming unit (7) fixed remavably to the vicinity of the center of the fastening band (5). The radiation image forming unit (7) is made by inserting a radiation image transformation plate (13) containing stimulable phosphor into a visible light shielding bag (15) and then inserting the light shielding bag (15) into a cloth bag (serving as a shock absorber) (17).

Description

明 細 書  Specification
放射性同位元素検出用プローブ、および放射性同位元素検出方法 技術分野  Radioisotope detection probe and radioisotope detection method
[0001] 本発明は、放射性同位元素検出用プローブ、および放射性同位元素検出方法に 関する。  The present invention relates to a radioisotope detection probe and a radioisotope detection method.
背景技術  Background art
[0002] 放射性同位元素 (ラジオアイソトープ)は、研究、教育、産業、医療等に幅広く利用 されている。  [0002] Radioisotopes are widely used in research, education, industry, medicine, and the like.
例えば、各種医学診断のために用いられている。また、作業者が、放射性同位元 素を誤った方法で使用すると、これが体内に摂取されて体内汚染を起こすおそれが ある。例えば、放射性ヨウ素を用いた場合には、摂取された放射性ヨウ素は甲状腺内 に蓄積されて甲状腺を被爆させる。  For example, it is used for various medical diagnoses. Also, if an operator uses a radioisotope in the wrong way, it may be ingested and cause body contamination. For example, when radioactive iodine is used, the ingested radioactive iodine accumulates in the thyroid gland and causes the thyroid gland to be exposed.
核医学検査では患者の放射性同位元素の摂取量や体内分布を調べるために、シ ンチレーシヨン検出器及びシンチレーションカメラ(シンチカメラ、ガンマカメラ)を用い た検査が行われている(例えば、特許文献 1参照)。  In nuclear medicine examinations, examinations using scintillation detectors and scintillation cameras (scintillation cameras, gamma cameras) are performed to examine the intake and distribution of radioactive isotopes in patients (for example, see Patent Document 1). ).
[0003] ところが、シンチレーションカメラを用いた検査では、患者等は、病院や大学等に出 向いて、シンチレーションカメラによって、放射性同位元素の蓄積量を測定しなけれ ばならな力つた。このため、例えば、患者が在宅の場合には、放射性同位元素の蓄 積量を測定することは困難であった。 [0003] However, in an examination using a scintillation camera, patients and the like had the power to go to hospitals and universities and measure the amount of accumulated radioisotopes with a scintillation camera. For this reason, for example, when the patient is at home, it has been difficult to measure the accumulated amount of radioisotope.
特許文献 1:特開平 7— 333344号公報  Patent Document 1: Japanese Patent Laid-Open No. 7-333344
発明の開示  Disclosure of the invention
発明が解決しょうとする課題  Problems to be solved by the invention
[0004] 一方、シンチレーションカメラの代わりに、輝尽性蛍光体を含有する放射線像変換 板を用いた方法が考案されている。放射線像変換板は、 X線フィルムに代わる二次 元放射線検出媒体であり、専用の画像解析装置と組み合わせたシステムで利用され るものである。 On the other hand, a method using a radiation image conversion plate containing a stimulable phosphor instead of a scintillation camera has been devised. The radiation image conversion plate is a two-dimensional radiation detection medium that replaces the X-ray film, and is used in a system combined with a dedicated image analyzer.
[0005] しカゝしながら、これまでの放射線像変換板の使用方法では感度がそれ程高くな!/ヽ ために、露光時間が長ぐ潜像形成中に被検者と放射線像変換板との相対位置が 変化しやすく、像がぶれやす ヽと ヽぅ問題点があった。 [0005] However, the sensitivity of the conventional method of using a radiation image conversion plate is so high! For this reason, the relative position between the subject and the radiation image conversion plate is likely to change during the formation of a latent image with a long exposure time, and the image may be blurred.
本発明は、上記事情に鑑みてなされたもので、輝尽性蛍光体を含有する放射線像 変換板を備え、高感度で鮮明な像を得るための放射性同位元素検出用プローブ、 および放射性同位元素検出方法を提供することを目的とする。  The present invention has been made in view of the above circumstances, and includes a radiation image conversion plate containing a photostimulable phosphor, a radioisotope detection probe for obtaining a clear image with high sensitivity, and a radioisotope An object is to provide a detection method.
課題を解決するための手段  Means for solving the problem
[0006] 上記の目的を達成するための手段として、請求の範囲第 1項の発明は、被験者の 所定器官に存在する放射性同位元素の放射線像を得るための放射性同位元素検 出用プローブであって、被験者の所定部位に固定可能に構成された固定具と、この 固定具に支持固定され、可視光を遮光する遮光袋と、この遮光袋内に挿入され、輝 尽性蛍光体を含有する放射線像変換板とを備えていることを特徴とする放射性同位 元素検出用プローブである。  [0006] As means for achieving the above object, the invention of claim 1 is a radioisotope detection probe for obtaining a radiographic image of a radioisotope existing in a predetermined organ of a subject. A fixture that can be fixed to a predetermined part of the subject, a light-shielding bag that is supported and fixed to the fixture and shields visible light, and is inserted into the light-shielding bag and contains a stimulable phosphor. A radioisotope detection probe comprising a radiation image conversion plate.
[0007] 請求の範囲第 2項の発明は、請求の範囲第 1項に記載のものにおいて、前記遮光 袋の前記所定部位と対向する面側には、前記放射線像変換板の面に対して交わる 方向に貫通した複数の貫通孔を設けた鉛含有のコリメータが備えられていることを特 徴とする。 [0007] The invention of claim 2 is the invention of claim 1, wherein the surface of the light shielding bag facing the predetermined portion is on the surface of the radiation image conversion plate. It is characterized by a lead-containing collimator provided with a plurality of through holes penetrating in the intersecting direction.
[0008] 請求の範囲第 3項の発明は、請求の範囲第 1項に記載のものにおいて、前記遮光 袋の前記所定部位に面する側は、緩衝材により被覆されていることを特徴とする。  [0008] The invention of claim 3 is the invention of claim 1, characterized in that the side of the light shielding bag facing the predetermined portion is covered with a cushioning material. .
[0009] 請求の範囲第 4項の発明は、請求の範囲第 2項又は請求の範囲第 3項に記載のも のにおいて、前記コリメータの前記所定部位に面する側は、緩衝材により被覆されて いることを特徴とする。  [0009] The invention according to claim 4 is the invention according to claim 2 or claim 3, wherein the side of the collimator facing the predetermined portion is covered with a cushioning material. It is characterized by that.
[0010] 請求の範囲第 5項の発明は、請求の範囲第 1項ないし請求の範囲第 4項のいずれ かに記載のものにおいて、前記遮光袋が前記固定具と着脱可能に構成されているこ とを特徴とする。  [0010] The invention of claim 5 is the apparatus of any one of claims 1 to 4, wherein the light shielding bag is configured to be detachable from the fixture. It is characterized by this.
[0011] 請求の範囲第 6項の発明は、被験者の所定器官に存在する放射性同位元素の放 射線像を得るための放射性同位元素検出方法であって、輝尽性蛍光体を含有する 放射線像変換板を可視光を遮光する遮光部材により遮光した状態で被験者の所定 部位に固定する固定工程と、固定された前記放射線像変換板を所定時間放置する ことで前記放射線像変換板に潜像を形成させる潜像形成工程と、形成された前記潜 像を解析して前記放射線像を得る解析工程と、を経ることを特徴とする。 [0011] The invention of claim 6 is a radioisotope detection method for obtaining a radioisotope radiation image present in a predetermined organ of a subject, and a radiographic image containing a stimulable phosphor A fixing step of fixing the conversion plate to a predetermined part of the subject in a state where the conversion plate is shielded by a light shielding member that shields visible light, and the fixed radiation image conversion plate is left for a predetermined time. Thus, a latent image forming step of forming a latent image on the radiation image conversion plate and an analyzing step of analyzing the formed latent image to obtain the radiation image are characterized.
発明の効果  The invention's effect
[0012] <請求の範囲第 1項および請求の範囲第 6項の発明 >  <Invention of Claims 1 and 6>
本請求の範囲の発明の放射性同位元素検出用プローブは、以下のようにして使用 される。すなわち、まず、放射線像変換板を挿入した遮光袋が支持固定された固定 具を被験者の所定部位 (例えば、首)に固定する。この状態で、所定時間経過するの を待つと、放射線像変換板に潜像が形成される。潜像が形成された後に、暗室内で 放射線像変換板を遮光袋カゝら取り出して、専用の画像解析装置により画像を得る。  The probe for detecting a radioisotope of the invention of the present invention is used as follows. That is, first, a fixture having a light-shielding bag into which a radiation image conversion plate is inserted is supported and fixed to a predetermined part (eg, neck) of a subject. In this state, when waiting for a predetermined time to elapse, a latent image is formed on the radiation image conversion plate. After the latent image is formed, the radiation image conversion plate is taken out from the light shielding bag in the dark room, and an image is obtained by a dedicated image analysis device.
[0013] 本請求の範囲の放射性同位元素検出用プローブによれば、潜像を形成している間 、放射性同位元素検出用プローブは人体の所定部位に固定されるから、放射線像 変換板と所定部位の相対位置が変化せず、その結果、像がぶれず鮮明な像が得ら れる。  [0013] According to the radioisotope detection probe of the present invention, the radioisotope detection probe is fixed to a predetermined part of the human body while the latent image is formed. The relative position of the part does not change, and as a result, the image is not blurred and a clear image is obtained.
また、放射線像変換板は、遮光袋に入れられているから、形成された潜像が可視 光によって消去されない。  Further, since the radiation image conversion plate is placed in a light shielding bag, the formed latent image is not erased by visible light.
[0014] <請求の範囲第 2項の発明 > [0014] <Invention of Claim 2>
本請求の範囲の発明によれば、放射線像変換板の面に対して交わる方向に貫通 した複数の貫通孔を設けた鉛含有のコリメータが備えられているから、この方向の放 射線が選択的に通過して、放射線像変換板に形成される潜像の解像度が向上する  According to the invention of this claim, since the lead-containing collimator provided with a plurality of through holes penetrating in the direction intersecting the plane of the radiation image conversion plate is provided, the radiation in this direction is selective. And the resolution of the latent image formed on the radiation image conversion plate is improved.
[0015] <請求の範囲第 3項の発明 > [0015] <Invention of Claim 3>
本請求の範囲の発明によれば、固定具の所定部位に面する側は、緩衝材により被 覆されて!/、るから、所定部位を固定具によつて傷つけるおそれがな 、。  According to the invention of the present claims, the side of the fixture facing the predetermined part is covered with the cushioning material, so there is no risk of damaging the predetermined part with the fixture.
[0016] <請求の範囲第 4項の発明 > <Invention of Claim 4>
本請求の範囲の発明によれば、コリメータの所定部位に面する側は、緩衝材により 被覆されているから、所定部位をコリメータによって傷つけるおそれがない。  According to the invention of this claim, since the side facing the predetermined part of the collimator is covered with the cushioning material, there is no possibility that the predetermined part is damaged by the collimator.
[0017] <請求の範囲第 5項の発明 > <0017> <Invention of Claim 5>
本請求の範囲の発明によれば、遮光袋が固定具と着脱可能に構成されているから 、放射線像変換板が挿入された遮光袋を取り外して暗室に運び解析すればよぐ運 搬に便利である。 According to the invention of this claim, the light shielding bag is configured to be detachable from the fixture. It is convenient to carry it by removing the light shielding bag with the radiation image conversion plate inserted and carrying it to the darkroom for analysis.
図面の簡単な説明 Brief Description of Drawings
[図 1]図 1は、第 1実施形態の放射性同位元素検出用プローブの平面図である。 FIG. 1 is a plan view of a radioisotope detection probe according to a first embodiment.
[図 2]図 2は、放射性同位元素検出用プローブの断面図(図 1の A— A断面図)である  [Fig. 2] Fig. 2 is a cross-sectional view of the probe for detecting a radioisotope (A-A cross-sectional view of Fig. 1).
[図 3]図 3は、放射性同位元素検出用プローブの分解平面図である。 FIG. 3 is an exploded plan view of a probe for detecting radioisotopes.
[図 4]図 4は、放射線像形成ユニットの表側カゝら見た斜視図、及び裏側から見た斜視 図である。  FIG. 4 is a perspective view of the radiation image forming unit as seen from the front side and a perspective view from the back side.
[図 5]図 5は、遮光袋及び放射線像変換板を示す斜視図である。  FIG. 5 is a perspective view showing a light shielding bag and a radiation image conversion plate.
[図 6]図 6は、放射性同位元素検出用プローブを首に取り付けた様子を示す斜視図 である。  [Fig. 6] Fig. 6 is a perspective view showing a state in which a radioactive isotope detection probe is attached to the neck.
[図 7]図 7は、第 2実施形態の放射性同位元素検出用プローブの斜視図である。  FIG. 7 is a perspective view of the radioactive isotope detection probe of the second embodiment.
[図 8]図 8は、図 7の断面図である。 FIG. 8 is a cross-sectional view of FIG.
[図 9]図 9は、放射性同位元素検出用プローブの分解斜視図である。  FIG. 9 is an exploded perspective view of a radioactive isotope detection probe.
[図 10]図 10は、コリメータの平面図((A);コリメータ A、(B) ;コリメータ B、(C)コリメ一 タ C)である。  FIG. 10 is a plan view of the collimator ((A); collimator A, (B); collimator B, (C) collimator C).
[図 11]図 11は、放射性同位元素検出用プローブを首に取り付けた様子を示す斜視 図である。  FIG. 11 is a perspective view showing a state in which a radioactive isotope detection probe is attached to the neck.
[図 12]図 12は、実施例における首—甲状腺模型の模式的斜視図である。  FIG. 12 is a schematic perspective view of a neck-thyroid model in the example.
[図 13]図 13は、各放射性同位元素検出用プローブ使用時の画像((A);放射性同 位元素検出用プローブ使用 A使用時、(B);放射性同位元素検出用プローブ B使用 時、(C) ;放射性同位元素検出用プローブ C使用時、(D);放射性同位元素検出用 プローブ D使用時)である。 [Fig.13] Figure 13 shows images when using each radioisotope detection probe ((A); using radioisotope detection probe A, (B); using radioisotope detection probe B, (C): When using radioisotope detection probe C, (D): When using radioisotope detection probe D).
[図 14]図 14は、第 3実施形態の放射性同位元素検出用プローブの斜視図である。  FIG. 14 is a perspective view of a radioisotope detection probe of a third embodiment.
[図 15]図 15は、遮光袋内に収められた放射線像変換板胸当て部に収容する様子を 示す部分拡大斜視図である。 [FIG. 15] FIG. 15 is a partially enlarged perspective view showing a state in which the radiation image converting plate breastplate portion housed in the light shielding bag is housed.
[図 16]図 16は、放射性同位元素検出用プローブを被験者の胴体部に装着した様子 を示す斜視図である。 [FIG. 16] FIG. 16 shows a radioisotope detection probe mounted on the body of a subject. FIG.
符号の説明  Explanation of symbols
[0019] 1…放射性同位元素検出用プローブ  [0019] 1 ... Radioisotope detection probe
3…首 (所定部位)  3 ... Neck (predetermined part)
5…固定具  5 ... Fixing tool
7· ··放射線像形成ユニット  7. Radiation imaging unit
13· ··放射線像変換板  13 ··· Radiation image converter
15…遮光袋  15 ... Shading bag
17…布袋 (緩衝材)  17… Cloth bag (buffer material)
発明を実施するための最良の形態  BEST MODE FOR CARRYING OUT THE INVENTION
[0020] <第 1実施形態 >  [0020] <First embodiment>
本発明の第 1実施形態について図 1から図 6を参照して説明する。本実施形態の放 射性同位元素検出用プローブ 1は、被験者の甲状腺 (所定器官に相当)に蓄積して V、る12 及び1311の放射線像を得るためのものである。この放射性同位元素検出用プ ローブ 1は、全体として湾曲帯状に形成されており、被験者の首 3 (所定部位に相当) に巻き付けることによって首 3に固定可能に構成された固定具 5と、この固定具 5の中 央付近に着脱自在に装着された放射線像形成ユニット 7とからなる。 A first embodiment of the present invention will be described with reference to FIGS. The radioactive isotope detection probe 1 of this embodiment is for accumulating in a subject's thyroid gland (corresponding to a predetermined organ) to obtain radiation images of V, 12 and 131 1. This radioisotope detection probe 1 is formed in a curved belt shape as a whole, and has a fixture 5 configured to be fixed to the neck 3 by being wound around the neck 3 (corresponding to a predetermined site) of the subject. The radiographic image forming unit 7 is detachably mounted near the center of the fixture 5.
[0021] 固定具 5は、全体として湾曲帯状の例えば発砲ウレタン榭脂などの軟質合成樹脂 製で、首 3に対してほぼ一巻状に卷回される長さと、首 3の長さに相当する幅とを有 する。固定具 5の片端には、面ファスナ 9Aを備えたバンド 9が取り付けられており、固 定具 5の他端付近には、バンド 9の面ファスナ 9Aと係着可能な面ファスナ 11が取り付 けられている。固定具 5は、首 3に巻き付けた状態で、面上ファスナ 9A, 11同士を係 着させることで首 3に固定されるようになって 、る。  [0021] The fixture 5 is made of a soft synthetic resin such as a foamed urethane resin having a curved band as a whole, and corresponds to the length of the neck 3 wound around the neck 3 and the length of the neck 3. Width. A band 9 having a hook and loop fastener 9A is attached to one end of the fixture 5, and a hook and loop fastener 11 that can be engaged with the hook and loop fastener 9A of the band 9 is attached near the other end of the fixture 5. It is The fastener 5 is fixed to the neck 3 by engaging the fasteners 9A and 11 on the surface in a state of being wound around the neck 3.
[0022] 放射線像形成ユニット 7は、全体として湾曲帯状で、固定具 5の長さのほぼ 1Z3程 度の長さで、かつ固定具 5とほぼ同一幅とされ、その裏面の縁部 6力所に面ファスナ 7 Aが設けられており、この面ファスナ 7Aが固定具 5の表面に設けられた面ファスナ 5 Aと係着して固定されるようになっている。放射線像形成ユニット 7は、詳細には、図 5 に示すように輝尽性蛍光体を含有する放射線像変換板 13を可視光を遮る遮光袋 15 に挿入し、図 4に示すようにさらに遮光袋 15を布袋 17 (本発明の緩衝材に相当)に 挿入してなる。 [0022] The radiation image forming unit 7 has a curved belt shape as a whole, is approximately 1Z3 in length of the fixture 5, and is approximately the same width as the fixture 5. A hook-and-loop fastener 7A is provided at this location, and the hook-and-loop fastener 7A is engaged with and fixed to the hook-and-loop fastener 5A provided on the surface of the fixture 5. In detail, the radiation image forming unit 7 includes a light shielding bag 15 for blocking visible light from a radiation image conversion plate 13 containing a stimulable phosphor as shown in FIG. As shown in FIG. 4, a light shielding bag 15 is further inserted into a cloth bag 17 (corresponding to the cushioning material of the present invention).
[0023] 放射線像変換板 13としては、例えば、富士写真フィルム (株)製の商品名:イメージ ングプレートを用いることができる。遮光袋 15は、放射線像変換板 13に形成された 潜像が可視光により消去されることを防止するためのもので、例えばポリエチレンにァ ルミ-ゥムをラミネートした素材力もなる遮光袋 15を使用できる。布袋 17は、被験者 の首 3の皮膚を傷つけな 、ように表面の柔らかな素材力もなるものが好ま 、。  [0023] As the radiation image conversion plate 13, for example, a product name: Imaging Plate manufactured by Fuji Photo Film Co., Ltd. can be used. The light shielding bag 15 is for preventing the latent image formed on the radiation image conversion plate 13 from being erased by visible light. For example, the light shielding bag 15 having a material strength obtained by laminating aluminum on polyethylene is used. Can be used. The cloth bag 17 preferably has a soft material on the surface so that the skin of the neck 3 of the subject is not damaged.
[0024] 次に、上記構成からなる本実施形態の放射性元素検出用プローブ 1の作用効果に ついて説明する。  Next, the function and effect of the radioactive element detection probe 1 of the present embodiment configured as described above will be described.
まず、輝尽性蛍光体を含有する放射線像変換板 13を遮光袋 15に挿入し、さらに 遮光袋 15を布袋 17に挿入して放射線像形成ユニット 7とする。そして、この放射線像 形成ユニット 7を固定具 5に装着して放射性同位元素検出用プローブ 1とし、放射性 同位元素検出用プローブ 1を放射線像形成ユニット 7が被験者の首 3の喉側に面す るようにして首 3に固定する(図 6参照)。このようにすると、甲状腺と放射線像変換板 13とが対面し、放射線像変換板 13に潜像が形成される。  First, the radiation image conversion plate 13 containing the stimulable phosphor is inserted into the light shielding bag 15, and the light shielding bag 15 is further inserted into the cloth bag 17 to form the radiation image forming unit 7. The radiographic image forming unit 7 is attached to the fixture 5 to form a radioisotope detection probe 1, and the radioisotope detection probe 1 faces the throat side of the neck 3 of the subject. In this way, fix it to the neck 3 (see Fig. 6). In this way, the thyroid gland and the radiation image conversion plate 13 face each other, and a latent image is formed on the radiation image conversion plate 13.
[0025] 次に、固定状態のまま所定時間、例えば 3〜20分間経過するのを待つ。なお、この 待ち時間の間に、被験者は自由に姿勢を変えることもでき、歩行や仕事をすることも 可能である。放射性同位元素検出用プローブ 1の首 3への固定により、甲状腺と放射 線像変換板 13との相対位置が変化しないからである。  [0025] Next, it waits for a predetermined time, for example, 3 to 20 minutes to pass in the fixed state. During this waiting time, the subject can freely change his / her posture and can walk and work. This is because fixing the radioisotope detection probe 1 to the neck 3 does not change the relative position between the thyroid gland and the radiation image conversion plate 13.
[0026] その後、放射性同位元素検出用プローブ 1を首 3から外し、放射性同位元素検出 用プローブ 1から放射線像形成ユニット 7を外す。放射線像形成ユニット 7又は放射 線像形成ユニット 7から取り出した遮光袋 15を暗室内に運び、放射線像変換板 13を 取り出して、専用の画像解析装置 (例えば、 BAS-2500 富士写真フィルム)により画 像を得る。  Thereafter, the radioisotope detection probe 1 is removed from the neck 3, and the radiation image forming unit 7 is removed from the radioisotope detection probe 1. The light shielding bag 15 taken out from the radiation image forming unit 7 or the radiation image forming unit 7 is carried into the dark room, the radiation image conversion plate 13 is taken out, and the image is captured by a dedicated image analyzer (for example, BAS-2500 Fuji Photo Film). Get a statue.
[0027] 本実施形態の放射性同位元素検出用プローブ 1によれば、潜像を形成して!/、る間 、放射性同位元素検出用プローブ 1は被験者体の首 3と固定されるから、甲状腺と放 射線像変換板 13との相対位置が変化せず、その結果、像がぶれず鮮明な像が得ら れる。 [0028] また、放射線像形成ユニット 7と首 3とをほぼ密着状態とすることができ、放射線像変 換板 13と甲状腺との距離が近くなるから、感度が向上する。 [0027] According to the radioisotope detection probe 1 of the present embodiment, while forming a latent image, the radioisotope detection probe 1 is fixed to the neck 3 of the subject body. And the relative position of the radiation image conversion plate 13 do not change, and as a result, the image is not blurred and a clear image is obtained. [0028] In addition, the radiation image forming unit 7 and the neck 3 can be brought into a close contact state, and the distance between the radiation image conversion plate 13 and the thyroid gland is reduced, so that the sensitivity is improved.
また、本実施形態の放射性同位元素検出用プローブ 1によれば、放射性同位元素 検出用プローブ 1から、放射線像形成ユニット 7及び遮光袋 15が着脱可能に構成さ れているから、放射線像形成ユニット 7又は遮光袋 15を暗室内に運び解析すればよ ぐ運搬に便利である。  Further, according to the radioisotope detection probe 1 of the present embodiment, since the radiation image forming unit 7 and the light shielding bag 15 are detachable from the radioisotope detection probe 1, the radiation image forming unit It is convenient to carry 7 or the light shielding bag 15 in the dark room and analyze it.
[0029] <第 2実施形態 > [0029] <Second Embodiment>
本発明の第 2実施形態について図 7から図 13を参照して説明する。なお、第 1実施 形態と同じ構成については、同一の符号を付し、構造、作用及び効果の説明は省略 する。  A second embodiment of the present invention will be described with reference to FIGS. Note that the same components as those in the first embodiment are denoted by the same reference numerals, and description of the structure, operation, and effect is omitted.
第 2実施形態では、主として固定具 5の構造及びコリメータ 21を備える点が第 1実 施形態と異なっている。  The second embodiment is different from the first embodiment mainly in that the structure of the fixture 5 and the collimator 21 are provided.
[0030] 本実施形態の放射性同位元素検出用プローブ 1は、第 1実施形態と同様に、被験 者の甲状腺に蓄積して 、る12 及び miの放射線像を得るためのものである。この放射 性同位元素検出用プローブ 1は、図 7〜9に示すように全体として門形断面形状に形 成されており、ベット上に仰向けに横たわる被験者の首 3に跨ぐように嵌め込まれて 首 3に固定可能に構成されている(図 11参照)。 [0030] radioisotope detector probe 1 of this embodiment, like the first embodiment, accumulated in the thyroid of subjects, is for obtaining a radiation image of the Ru 12 and m i. This radioisotope detection probe 1 is formed in a portal cross-sectional shape as a whole as shown in FIGS. 7 to 9, and is fitted over the neck 3 of a subject lying on his / her back on a bed. It can be fixed to 3 (see Fig. 11).
[0031] 固定具 5は、図 9に示すように、中央に開口部を有する略矩形枠状の上面壁 23と、 上面壁 23の左右両側端力も下方へ延出する一対の側片 25と、上面壁 23の開口部 を覆う蓋部 27により構成され全体として門形状をなしている。各側片 25の下端面に は、高さ調整用のねじ式の脚部 25Aが設けられている。脚部 25Aは、その雄ねじ部 が側片 25の下端面から上方に向かって穿設されたねじ孔 25Bに螺合されており、脚 部 25Aを右回り又は左回りにまわすことで、上面壁 23が上下方向に変位するように されている。このようにして、上面壁 23の高さを被験者の首の高さに応じて調節でき るようになっている。  As shown in FIG. 9, the fixture 5 includes a substantially rectangular frame-shaped upper surface wall 23 having an opening in the center, and a pair of side pieces 25 that extend downward on both the left and right ends of the upper surface wall 23. The lid portion 27 that covers the opening of the upper wall 23 forms a gate shape as a whole. On the lower end surface of each side piece 25, a screw-type leg portion 25A for height adjustment is provided. The leg portion 25A is screwed into a screw hole 25B whose upper end is threaded upward from the lower end surface of the side piece 25. By turning the leg portion 25A clockwise or counterclockwise, the top wall 23 is displaced in the vertical direction. In this way, the height of the top wall 23 can be adjusted according to the height of the subject's neck.
[0032] 上面壁 23と蓋部 27との間には、下力も順にコリメータ 21、輝尽性蛍光体を含有す る放射線像変換板 13を挿入した遮光袋 15がほぼ水平に配されており、締め金具 28 を締めることにより、コリメータ 21と遮光袋 15とが圧着されつつ、上面壁 23と蓋部 27 間に挟持される。そして、コリメータ 21の下面が開口力も露出するようにされている。 なお、図 8、 9に示すように、コリメータ 21の下面及び両側片 25の内側には、ポリウレ タンスポンジ等の弹性榭脂 29A周りに柔らカゝ 、布 29Bを被覆した緩衝材 29が配され ており、これらの緩衝材 29により首 3を傷つけないようにするとともに、首 3がこれらの 緩衝材 29により三方向から支持固定され、首 3が若干左右に若干振れたとしても固 定具 5と首 3の相対位置が変化しな 、ようにされて 、る。 [0032] Between the top wall 23 and the lid portion 27, a collimator 21 and a light shielding bag 15 into which a radiation image conversion plate 13 containing a stimulable phosphor is inserted are arranged almost horizontally. By tightening the fastener 28, the collimator 21 and the light shielding bag 15 are crimped while the top wall 23 and the lid 27 Sandwiched between. The lower surface of the collimator 21 is also exposed to the opening force. As shown in FIGS. 8 and 9, on the lower surface of the collimator 21 and the inside of the both side pieces 25, a cushioning material 29 covered with a soft cloth and a cloth 29B is disposed around an elastic resin 29A such as a polyurethane sponge. These cushioning materials 29 prevent the neck 3 from being damaged, and the neck 3 is supported and fixed in three directions by these cushioning materials 29, so that the fixing tool 5 is fixed even if the neck 3 slightly swings left and right. And the relative position of the neck 3 does not change.
[0033] コリメータ 21は、全体として鉛製の板状をなし、放射線像変換板 13の面に対して交 わる方向に貫通した複数の貫通孔 31が設けられて 、る。 The collimator 21 has a lead plate shape as a whole, and is provided with a plurality of through holes 31 penetrating in a direction intersecting the surface of the radiation image conversion plate 13.
詳細には、コリメータ 21は図 10に示すように、例えば、高さ 10mm、壁の厚さ 0. 14 mm、内径 3mmの鉛製円筒管がハ-カム状に配置して相互連結されたもの(図 10 ( A)参照、以下コリメータ A)や、(b)高さ 20mm、壁の厚さ 0. 14mm,内径 2mmの鉛 製円筒管がハ-カム状に配置して相互連結されたもの(図 10 (B)参照、以下コリメ一 タ B)や、(c)高さ 40mm、壁の厚さ 0. 2mm、対角径 2mmの鉛製正六角形の管がハ 二カム状に配置して相互連結されたもの(図 10 (C)参照、以下コリメータ C)が使用さ れる。  Specifically, as shown in FIG. 10, the collimator 21 is, for example, a lead cylindrical tube having a height of 10 mm, a wall thickness of 0.14 mm, and an inner diameter of 3 mm arranged in a hermetic manner and interconnected. (See Fig. 10 (A), below collimator A), and (b) Lead cylindrical tubes with a height of 20 mm, wall thickness of 0.14 mm, and inner diameter of 2 mm arranged in a hard cam and interconnected. (See Fig. 10 (B), below collimator B) and (c) Lead hexagonal pipes with a height of 40 mm, wall thickness of 0.2 mm, and diagonal diameter of 2 mm arranged in a double cam shape. Interconnected (see Fig. 10 (C), collimator C).
[0034] 本実施形態の構成によれば、コリメータ 21が備えられているから、貫通孔 31の方向 の放射線が選択的に通過して、放射線像変換板 13に形成される像の解像度が向上 する。  According to the configuration of the present embodiment, since the collimator 21 is provided, the radiation in the direction of the through hole 31 selectively passes and the resolution of the image formed on the radiation image conversion plate 13 is improved. To do.
また、本実施形態の放射性同位元素検出用プローブ 1は、人の首 3に密着使用す るので、放射線像変換板 13と甲状腺との距離が近くなるから、感度がよい。  In addition, since the radioisotope detection probe 1 of the present embodiment is used in close contact with the human neck 3, the distance between the radiation image conversion plate 13 and the thyroid gland is close, so that the sensitivity is good.
また、本実施形態の放射性同位元素検出用プローブ 1を用いたシステムでは、放 射性同位元素検出用プローブ 1は、画像解析装置とは分離可能で、かつ小形軽量 であるため、被験者の病室や、在宅の被験者の自宅まで放射性同位元素検出用プ ローブ 1のみを運搬し、潜像を形成後、放射性同位元素検出用プローブ 1を、検査室 に持ち帰り画像解析装置により解析すればよい。従って、重症の患者、高齢者が検 查室に出向く必要はなぐこれらのものの負担を著しく軽減することができる。  Further, in the system using the radioisotope detection probe 1 of the present embodiment, the radioisotope detection probe 1 is separable from the image analysis apparatus and is small and lightweight, so that the subject's hospital room and Then, after transporting only the radioisotope detection probe 1 to the home of the subject at home and forming a latent image, the radioisotope detection probe 1 may be taken back to the laboratory and analyzed by an image analyzer. Therefore, it is possible to remarkably reduce the burden of these patients, which is not necessary for serious patients and elderly people to go to the examination room.
[0035] <実施例 > [0035] <Example>
ここで、第 2実施形態の放射性元素検出用プローブ 1を用いて行った実験について 詳細に説明する。 Here, an experiment conducted using the radioactive element detection probe 1 of the second embodiment This will be described in detail.
<放射性同位元素検出用プローブ A>  <Radioisotope detection probe A>
放射線像変換板 13として、イメージングプレート(医療用 IP ; ST— III、富士写真フ イルム)を 110mm X 200mmに切断して使用した。  As the radiation image conversion plate 13, an imaging plate (medical IP; ST-III, Fuji Photo Film) was cut into 110 mm X 200 mm and used.
イメージングプレートは使用の直前に 30分間消去器を用いて残像を消去した。そし て、イメージングプレートは、白色光 (可視光)による潜像消去を防ぐために遮光袋 15 に挿入した。そして、上記コリメータ Aと合わせた状態で固定具 5にセットし図 7に示す 放射性同位元素検出用プローブ Aとした。  The imaging plate erased the afterimage using an eraser for 30 minutes immediately before use. The imaging plate was inserted into the light shielding bag 15 to prevent the latent image from being erased by white light (visible light). Then, the radioisotope detection probe A shown in FIG.
[0036] <放射性同位元素検出用プローブ B> [0036] <Radioisotope detection probe B>
コリメータ Bを使用した以外は、放射性同位元素検出用プローブ Aと同様にして放 射性同位元素検出用プローブ Bを作製した。  Radioisotope detection probe B was prepared in the same manner as radioisotope detection probe A, except that collimator B was used.
<放射性同位元素検出用プローブ C >  <Radioisotope detection probe C>
コリメータ Cを使用した以外は、放射性同位元素検出用プローブ Aと同様にして放 射性同位元素検出用プローブ Cを作製した。  A radioactive isotope detection probe C was prepared in the same manner as the radioactive isotope detection probe A except that the collimator C was used.
<放射性同位元素検出用プローブ D>  <Radioisotope detection probe D>
コリメータを使用しないこと以外は、放射性同位元素検出用プローブ Aと同様にして 放射性同位元素検出用プローブ Dを作製した。  A radioisotope detection probe D was prepared in the same manner as radioisotope detection probe A, except that no collimator was used.
[0037] く放射線像の形成及び解析 > [0037] Formation and analysis of radiation images>
放射性同位元素検出用プローブ A〜Dをそれぞれ図 12に示す首—甲状腺模型 3 6にセットした。この首—甲状腺模型 36は、容積 20mlの中空の人体甲状腺模型 33 ( 京都科学製; 1. 8mm厚メタクリル榭脂製)を備えた模型 37と、この模型 37を包囲す る上下有底円筒状の首模型 41 (0. 5mm厚メタクリル榭脂製)とカゝらなる。(なお、首 模型 41は、側壁の一部を開口させ、ここに 0. 25mm厚のアクリルフィルム 41 Aを嵌 めこんである)。そして、人体甲状腺模型 33には合計で123I IMBqを充填し、更に首 模型 41内に水を充填してある。なお、放射性同位元素検出用プローブ A〜Dを首— 甲状腺模型 36にセットする際には、首模型 41の開口に嵌めこまれたアクリルフィルム 41 Aがコリメータ 21と対面するように配した。 Radioisotope detection probes A to D were set on the neck-thyroid model 36 shown in FIG. This neck-thyroid model 36 consists of a model 37 equipped with a 20-ml hollow human thyroid model 33 (manufactured by Kyoto Kagaku; 1. 8 mm-thick methacrylic resin) and a cylindrical shape with an upper and lower bottom that surrounds this model 37. Neck model 41 (0.5mm thick methacrylic resin) (Note that the neck model 41 has a part of the side wall opened, and a 0.25 mm thick acrylic film 41 A is fitted here). The human thyroid model 33 is filled with 123 I IMBq in total, and the neck model 41 is filled with water. When the radioisotope detection probes A to D were set on the neck-thyroid model 36, the acrylic film 41 A fitted in the opening of the neck model 41 was arranged so as to face the collimator 21.
照射時間は 10分間とし、照射後のイメージングプレートを画像解析装置 (BAS-250 0 富士写真フィルム)、パーソナルコンピュータ (Power Mac 8500/180,Apple Comput er)、測定ソフト (Image Reader ver.3.30 富士写真フィルム)、解析ソフト(Image Gauge ver.3.30 富士写真フィルム)により解析した。画像解析装置の読み取り感度は S 100 0に設定した。 The irradiation time is 10 minutes, and the imaging plate after irradiation is image analysis equipment (BAS-250 0 Fuji Photo Film), personal computer (Power Mac 8500/180, Apple Computer), measurement software (Image Reader ver.3.30 Fuji Photo Film), analysis software (Image Gauge ver.3.30 Fuji Photo Film). The reading sensitivity of the image analyzer was set to S1000.
[0038] 結果を図 13に示す。なお、(A)は放射性同位元素検出用プローブ A使用時、(B) は放射性同位元素検出用プローブ B使用時、(C)は放射性同位元素検出用プロ一 ブ C使用時、(D)は放射性同位元素検出用プローブ D使用時の画像である。放射性 同位元素検出用プローブ A〜Cを使用した場合は、コリメータ無しの放射性同位元 素検出用プローブ D使用時よりも画像の解像度が向上し、人体甲状腺模型 33の形 状が明確に観察された。  [0038] The results are shown in FIG. (A) is when using radioisotope detection probe A, (B) is when using radioisotope detection probe B, (C) is when using radioisotope detection probe C, (D) is It is an image when the probe D for detecting a radioisotope is used. When the radioisotope detection probes A to C were used, the image resolution was higher than when the radioisotope detection probe D without a collimator was used, and the shape of the human thyroid model 33 was clearly observed. .
[0039] <第 3実施形態 >  [0039] <Third embodiment>
以下、本発明の第 3実施形態について、図 14〜図 16を参照しつつ説明する。本実 施形態の放射性同位元素検出用プローブ 50は、被験者 Sの胴体部 B (本発明の所 定部位に該当)に存在する肺、肝臓、胃腸、骨髄等の器官 (本発明の所定器官に該 当)に蓄積する放射性同位元素の放射線像を得るためのものである。  Hereinafter, a third embodiment of the present invention will be described with reference to FIGS. The radioisotope detection probe 50 of this embodiment is an organ (such as the lung, liver, gastrointestinal tract, bone marrow, etc.) present in the body B of subject S (corresponding to a predetermined site of the present invention). This is to obtain a radiographic image of the radioisotope accumulated in the corresponding).
[0040] 本実施形態の放射性同位元素検出用プローブ 50は、被験者 Sの胴体部 Bに取り 付けられるエプロン部 51 (本発明の固定具に該当する)と、このエプロン部 51に装着 される遮光袋 59および放射線像変換板 58とを備えている(図 14参照)。  [0040] The radioisotope detection probe 50 of the present embodiment includes an apron 51 (corresponding to the fixture of the present invention) attached to the body B of the subject S, and a light shield attached to the apron 51. A bag 59 and a radiation image conversion plate 58 are provided (see FIG. 14).
エプロン部 51は、被験者 Sの胴体部 Bにおいて胸側に宛がわれる胸当て部 52 (本 発明の緩衝材に該当する)と、および背中側に宛がわれる背当て部 53 (同じく本発 明の緩衝材に該当する)を備えている。  The apron 51 includes a breast pad 52 (corresponding to the cushioning material of the present invention) that is addressed to the chest side in the body B of the subject S, and a back pad 53 (also of the present invention) that is addressed to the back side. Corresponding to cushioning material).
[0041] 胸当て部 52は、綿などの布地により矩形の袋状に形成されたもので、その大きさは 被験者 Sの胸部のほぼ全体を覆うことが可能な大きさとされている。この胸当て部 52 において開口部 52Aの内側には、開口縁に沿って長尺の面ファスナ 52Bが取り付け られ、これにより袋の口を開閉できるようにされている。一方、背当て部 53は、胸当て 部 52とほぼ同形の矩形袋状に形成されており、その開口部 53Aは同様に面ファスナ 53Bにより開閉できるようにされている。これら胸当て部 52および背当て部 53は、そ れぞれ開口部 52A、 53Aを下側にして被験者 Sに装着される。 [0042] 胸当て部 52の上端縁(開口縁と対向する側の縁部)には、左右方向の中央よりや や外側位置に、一対の肩紐部 54の一端部が接続されており、この肩紐部 54の他端 部は、背当て部 53の上端縁(開口縁と対向する側の縁部)において左右方向の中央 よりやや外側位置にそれぞれ接続されている。一対の肩紐部 54の間隔は、被験者 S の頭部および首部が通過可能な間隔とされて 、る。これらの肩紐部 54にはアジヤス タ 55が備えられており、長さを自在に調節できるようにされて!/、る。 [0041] The breast pad portion 52 is formed in a rectangular bag shape with a cloth such as cotton, and the size of the chest pad portion 52 is set to be able to cover almost the entire chest of the subject S. In the breast pad portion 52, a long surface fastener 52B is attached to the inside of the opening portion 52A along the opening edge so that the mouth of the bag can be opened and closed. On the other hand, the back pad 53 is formed in a rectangular bag shape that is substantially the same shape as the breast pad 52, and its opening 53A can be similarly opened and closed by a surface fastener 53B. The breast pad portion 52 and the back pad portion 53 are attached to the subject S with the openings 52A and 53A facing down, respectively. [0042] One end of a pair of shoulder straps 54 is connected to the upper edge of the breast pad 52 (the edge on the side facing the opening edge) slightly outside the center in the left-right direction. The other end of the shoulder strap 54 is connected to a position slightly outside the center in the left-right direction at the upper edge of the back pad 53 (the edge on the side facing the opening edge). The interval between the pair of shoulder straps 54 is an interval through which the head and neck of the subject S can pass. These shoulder straps 54 are equipped with an agitator 55 so that the length can be adjusted freely! /
[0043] 背当て部 53の両側縁下端位置からは、それぞれ帯部 56が幅方向外側に向力つて 延出されている。この帯部 56において、被験者 Sが装着した際に内側 (被験者 Sの胴 体部 Bと対向する側)となる面には、ほぼ全面にわたって面ファスナ 57のループテー プ 57Aが取り付けられている。一方、胸当て部 52には、被験者 Sが装着した際に外 側となる面の下端位置において左右両端位置に、それぞれ面ファスナ 57において ループテープ 57Aと対となるフックテープ 57Bが取り付けられて!/、る。この面ファスナ 57により、帯部 56を延出方向の任意位置において胸当て部 52に固着することがで きる。  [0043] From the lower end positions of both side edges of the backrest portion 53, the belt portions 56 are each extended outward in the width direction. In the band portion 56, a loop tape 57A of a hook-and-loop fastener 57 is attached almost entirely to the surface which is the inner side (the side facing the body portion B of the subject S) when the subject S wears it. On the other hand, hook tape 57B, which is paired with loop tape 57A in hook-and-loop fastener 57, is attached to breast pad 52 at the left and right end positions at the lower end position of the outer surface when subject S wears! / RU With this surface fastener 57, the band 56 can be fixed to the breast pad 52 at an arbitrary position in the extending direction.
[0044] 胸当て部 52および背当て部 53の内部には、遮光袋 59の内部に収容された放射 線像変換板 58が収容される。放射線像変換板 58としては、上記実施形態と同様、 輝尽性蛍光体を含有するものであって、例えば、富士写真フィルム (株)製の商品名 :イメージングプレートを用いることができる。遮光袋 59としては、上記実施形態と同 様、可視光を遮ることで、放射線像変換板 58に形成された潜像が消去されることを 防止できるものであればよぐ例えばポリエチレンにアルミニウムをラミネートした素材 力 なるものを使用できる。  [0044] Inside the breast pad portion 52 and the back pad portion 53, a radiation image conversion plate 58 housed in the light shielding bag 59 is housed. The radiation image conversion plate 58 contains a stimulable phosphor as in the above embodiment, and for example, trade name: Imaging Plate manufactured by Fuji Photo Film Co., Ltd. can be used. As the light shielding bag 59, as long as it can prevent the latent image formed on the radiation image conversion plate 58 from being erased by blocking visible light, as in the above-described embodiment, for example, aluminum is used for polyethylene. Laminated materials can be used.
[0045] この放射性同位元素検出用プローブ 50を用いて被験者 Sの検査を行う際には、ま ず、遮光袋 59内に収められた放射線像変換板 58を、エプロン部 51における胸当て 部 52および背当て部 53の内部に収容し、開口部 52A、 53Aを閉じる(図 15参照)。  [0045] When the subject S is inspected using the radioisotope detection probe 50, first, the radiation image conversion plate 58 housed in the light shielding bag 59 is attached to the breast pad 52 and the apron 51. It is accommodated in the back pad 53 and the openings 52A and 53A are closed (see FIG. 15).
[0046] 次に、エプロン部 51を被験者 Sの胴体部 Bに装着する(図 16参照)。まず、一対の 肩紐部 54の間に被験者 Sの首を通し、胸当て部 52が被験者 Sの胸部、背当て部 53 が背部に配されるようにして肩から吊り下げる。このとき、アジヤスタ 55を操作して胸 当て部 52および背当て部 53の高さが胸部および背部の検査したい位置に合致する ように調整する。次いで、被験者 Sの胸部に胸当て部 5を力 背部に背当て部 53を密 着させつつ、帯部 56を胸側に巻き付け、面ファスナ 57によってこの帯部 56と胸当て 部 53とを固着する。このとき、帯部 56の内側面には、ほぼ全面にわたってループテ ープ 57Aが取り付けられて 、るから、被験者 Sの体格に応じて帯部 56の巻き付け量 を調整し、帯部 56の延出方向の適切な位置において胸当て部 52側のフックテープ 57Bに固着することができる。 Next, the apron 51 is attached to the body B of the subject S (see FIG. 16). First, the subject's S neck is passed between a pair of shoulder straps 54, and the chest rest 52 is suspended from the shoulder so that the chest rest 52 is placed on the subject's S chest and the back rest 53 is placed on the back. At this time, the height of chest support 52 and back support 53 matches the position to be inspected on the chest and back by operating Ajista 55. Adjust as follows. Next, the band 56 is wrapped around the chest side while the chest pad 5 is firmly attached to the chest of the subject S and the back pad 53 is tightly attached to the back of the subject S. At this time, the loop tape 57A is attached to almost the entire inner surface of the belt portion 56. Therefore, the amount of winding of the belt portion 56 is adjusted according to the physique of the subject S, and the extension of the belt portion 56 is performed. It can be secured to the hook tape 57B on the breast pad 52 side at an appropriate position in the direction.
このようにして、被験者 Sの胸部に胸当て部 52が、背部に背当て部 53がほぼ密着 状態に宛がわれた状態でエプロン部 51が固定される。  In this way, the apron 51 is fixed in a state where the chest rest 52 is placed on the chest of the subject S and the back rest 53 is placed in close contact with the back.
[0047] なお、例えば被験者 Sの腹部や腰部を検査した 、場合には、アジヤスタ 55を操作し て胸当て部 52および背当て部 53の高さが腹部および腰部に合致するように調整す ればよい。 [0047] Note that, for example, when the abdomen and waist of the subject S are inspected, the height of the chest pad part 52 and the back pad part 53 may be adjusted so as to match the abdomen and waist part by operating the adjuster 55. Good.
[0048] この状態で、所定時間、例えば 3〜20分間経過するのを待ち、放射線像変換板 58 に潜像を形成させる。なお、この待ち時間の間に、被験者 Sは胸当て部 52および背 当て部 53の被験者 Sの胴体部 Bに対する相対位置が大きく変化しな 、範囲で自由 に姿勢を変えることもでき、歩行や簡単な仕事等をすることも可能である。  In this state, after waiting for a predetermined time, for example, 3 to 20 minutes, a latent image is formed on the radiation image conversion plate 58. During this waiting time, the subject S can change his / her posture freely within a range without changing the relative position of the chest pad 52 and the back pad 53 with respect to the body B of the subject S. It is also possible to do difficult work.
所定時間経過後、エプロン部 51を被験者 Sの胴体部 Bから外し、放射線像変換板 58の入った遮光袋 59を胸当て部 52および背当て部 53から取り外す。そして、この 遮光袋 59を暗室内に運び、放射線像変換板 58を取り出して、専用の画像解析装置 (例えば、 BAS-2500 富士写真フィルム)により解析する。被験者 Sが例えば 6GCo、 13 7Cs等の放射性物質を吸い込むこと等によりこれらの放射性物質が体内の各器官に 蓄積されていれば、これらの放射性物質力 発せられる放射線により、蓄積されてい る器官の位置や蓄積量に対応した画像が得られる。 After a predetermined time has elapsed, the apron 51 is removed from the body B of the subject S, and the light shielding bag 59 containing the radiation image conversion plate 58 is removed from the breast pad 52 and the back pad 53. Then, the light shielding bag 59 is carried into the dark room, the radiation image conversion plate 58 is taken out, and analyzed by a dedicated image analysis device (for example, BAS-2500 Fuji Photo Film). If subject S has ingested radioactive materials such as 6G Co, 13 7 Cs, etc., and these radioactive materials have accumulated in each organ in the body, the organs accumulated by the radiation generated by these radioactive materials An image corresponding to the position and the accumulation amount is obtained.
[0049] 以上のように本実施形態にぉ 、ても、潜像を形成して!/ヽる間、放射性同位元素検 出用プローブ 50が被験者 Sの胸部および背部にほぼ密着状態に固定されるから、 放射線像変換板 58と胸部および背部との相対位置が変化せず、その結果、像がぶ れず鮮明な像が得られる。また、従来のホールボディカウンタを使用する場合のよう な大掛かりな装置が必要なぐ被験者 Sを長時間拘束することもないため、例えば原 子力施設で働く作業員の内部被曝の有無の簡易な検査等に応用することができる。 <他の実施形態 > As described above, in this embodiment, the radioisotope detection probe 50 is fixed substantially in close contact with the chest and back of the subject S while forming a latent image! Therefore, the relative positions of the radiation image conversion plate 58 and the chest and back do not change, and as a result, the image is not blurred and a clear image is obtained. In addition, the subject S who does not need a large-scale device as in the case of using a conventional whole body counter is not restrained for a long time, so for example, a simple inspection of the presence or absence of internal exposure of a worker working at a nuclear power facility. Etc. <Other embodiments>
本発明は上記記述及び図面によって説明した実施形態に限定されるものではなく 、例えば次のような実施形態も本発明の技術的範囲に含まれ、さらに、下記以外にも 要旨を逸脱しない範囲内で種々変更して実施することができる。  The present invention is not limited to the embodiments described with reference to the above description and drawings. For example, the following embodiments are also included in the technical scope of the present invention, and are within the scope not departing from the gist other than the following. Various modifications can be made.
(1)上記第 1実施形態では、コリメータ 21を使用しない例を示したが、第 2実施形態 と同様にコリメータ 21を使用したものであってもよい。  (1) Although an example in which the collimator 21 is not used has been described in the first embodiment, the collimator 21 may be used in the same manner as in the second embodiment.
(2)上記第 2実施形態では、コリメータ 21は、所定の管がハ-カム状に配置された ものを例示したが、コリメータ 21を形成する管の形状、サイズ等は特に限定されない 。また、管を集合させたコリメータ 21に限定されず、鉛含有板に複数の貫通孔 31を 穿設したものであっても構わない。また、コリメータ 21の材質は鉛に限定されるもので はなぐ鉛以外の金属も使用可能である。  (2) In the second embodiment, the collimator 21 is exemplified by the one in which the predetermined pipes are arranged in the form of a heart cam. However, the shape and size of the pipes forming the collimator 21 are not particularly limited. Further, the present invention is not limited to the collimator 21 in which the tubes are assembled, and a plurality of through holes 31 may be formed in a lead-containing plate. The material of the collimator 21 is not limited to lead, and metals other than lead can also be used.
(3)本発明を適用できる所定器官としては、上記実施形態に例示した他に、例えば 、乳房、心臓、センチネルリンパ節、手関節、その他の各種臓器であってもよぐまた (3) As a predetermined organ to which the present invention can be applied, in addition to those exemplified in the above embodiment, for example, a breast, heart, sentinel lymph node, wrist joint, and other various organs may be used.
、所定部位としては、上記実施形態に例示した他に、例えば四肢、頭部等であっても よい。 The predetermined part may be, for example, an extremity, a head, or the like other than those exemplified in the above embodiment.
また、上記に例示した放射性同位元素の他に、 125I、 99mTc、 2Q1T1、 87Ga、 6QCo、 137Cs 、 2"An、その他人体を通過して人体外から検出されるような放射線を放出する放射 性同位元素の像を得るために本発明の放射性同位元素検出用プローブを使用して も構わない。 In addition to the radioisotopes exemplified above, 125 I, 99m Tc, 2Q1 T1, 87 Ga, 6Q Co, 137 Cs, 2 "An, and other radiation that can be detected from outside the human body The radioisotope detection probe of the present invention may be used to obtain an image of a radioisotope that emits.
(4)第 3実施形態では、胸当て部 52および背当て部 53を、開口部 52Aおよび 53A を下側として被験者 Sに装着したが、開口部を上または横に向けて装着しても構わな い。また、第 3実施形態では、帯部 56が取り付けられている側を背当て部 53としたが 、帯部が取り付けられている側を胸当て部としても構わない。  (4) In the third embodiment, the chest pad part 52 and the back pad part 53 are attached to the subject S with the openings 52A and 53A on the lower side, but they may be attached with the opening part facing up or sideways. Yes. In the third embodiment, the side to which the belt portion 56 is attached is the back pad portion 53, but the side to which the belt portion is attached may be the breast pad portion.

Claims

請求の範囲 The scope of the claims
[1] 被験者の所定器官に存在する放射性同位元素の放射線像を得るための放射性同 位元素検出用プローブであって、  [1] A radioactive isotope detection probe for obtaining a radiographic image of a radioisotope existing in a predetermined organ of a subject,
被験者の所定部位に固定可能に構成された固定具と、  A fixture configured to be fixable to a predetermined part of the subject;
この固定具に支持固定され、可視光を遮光する遮光袋と、  A light shielding bag that is supported and fixed to the fixture and shields visible light;
この遮光袋内に挿入され、輝尽性蛍光体を含有する放射線像変換板とを備えてい ることを特徴とする放射性同位元素検出用プローブ。  A radioisotope detection probe comprising a radiation image conversion plate inserted in the light shielding bag and containing a stimulable phosphor.
[2] 前記遮光袋の前記所定部位と対向する面側には、前記放射線像変換板の面に対 して交わる方向に貫通した複数の貫通孔を設けた鉛含有のコリメータが備えられてい ることを特徴とする請求の範囲第 1項に記載の放射性同位元素検出用プローブ。  [2] A lead-containing collimator provided with a plurality of through holes penetrating in a direction intersecting the surface of the radiation image conversion plate is provided on the surface of the light shielding bag facing the predetermined portion. The radioisotope detection probe according to claim 1, wherein the probe is for detecting a radioisotope.
[3] 前記遮光袋の前記所定部位に面する側は、緩衝材により被覆されて ヽることを特 徴とする請求の範囲第 1項に記載の放射性同位元素検出用プローブ。  [3] The probe for detecting a radioisotope according to claim 1, wherein a side facing the predetermined part of the light shielding bag is covered with a buffer material.
[4] 前記コリメータの前記所定部位に面する側は、緩衝材により被覆されていることを特 徴とする請求の範囲第 2項又は請求の範囲第 3項に記載の放射性同位元素検出用 プローブ。  [4] The radioisotope detection probe according to claim 2 or 3, wherein a side of the collimator facing the predetermined part is covered with a buffer material. .
[5] 前記遮光袋が前記固定具と着脱可能に構成されていることを特徴とする請求の範 囲第 1項ないし請求の範囲第 4項のいずれかに記載の放射性同位元素検出用プロ ーブ。  [5] The radioisotope detection probe according to any one of claims 1 to 4, wherein the light shielding bag is configured to be detachable from the fixture. B
[6] 被験者の所定器官に存在する放射性同位元素の放射線像を得るための放射性同 位元素検出方法であって、  [6] A radioisotope detection method for obtaining a radiographic image of a radioisotope existing in a predetermined organ of a subject,
輝尽性蛍光体を含有する放射線像変換板を可視光を遮光する遮光部材により遮 光した状態で前記被験者の所定部位に固定する固定工程と、  A fixing step of fixing the radiation image conversion plate containing the stimulable phosphor to the predetermined site of the subject in a state where the radiation image conversion plate is shielded by a light shielding member that shields visible light;
固定された前記放射線像変換板を所定時間放置することで前記放射線像変換板 に潜像を形成させる潜像形成工程と、  A latent image forming step of forming a latent image on the radiation image conversion plate by leaving the fixed radiation image conversion plate for a predetermined time; and
形成された前記潜像を解析して前記放射線像を得る解析工程と、を経ることを特徴 とする放射性同位元素検出方法。  Analyzing the formed latent image to obtain the radiation image, and a radioisotope detection method.
PCT/JP2005/015094 2004-10-04 2005-08-18 Probe for detecting radioactive isotope and method for detecting radioactive isotope WO2006038386A1 (en)

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