WO2006034652A1 - Method of optical treatment - Google Patents

Method of optical treatment Download PDF

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Publication number
WO2006034652A1
WO2006034652A1 PCT/CN2005/001605 CN2005001605W WO2006034652A1 WO 2006034652 A1 WO2006034652 A1 WO 2006034652A1 CN 2005001605 W CN2005001605 W CN 2005001605W WO 2006034652 A1 WO2006034652 A1 WO 2006034652A1
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WO
WIPO (PCT)
Prior art keywords
human eye
retina
defocus
producing
image
Prior art date
Application number
PCT/CN2005/001605
Other languages
French (fr)
Inventor
Chi Ho To
Siu Yin Lam
Yan Yin Tse
Original Assignee
The Hong Kong Polytechnic University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Hong Kong Polytechnic University filed Critical The Hong Kong Polytechnic University
Priority to AT05792006T priority Critical patent/ATE493096T1/en
Priority to EP05792006A priority patent/EP1799166B1/en
Priority to JP2007533857A priority patent/JP4891249B2/en
Priority to AU2005289302A priority patent/AU2005289302B2/en
Priority to DE602005025663T priority patent/DE602005025663D1/en
Priority to CN2005800411794A priority patent/CN101090686B/en
Publication of WO2006034652A1 publication Critical patent/WO2006034652A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/02—Simple or compound lenses with non-spherical faces
    • G02B3/08—Simple or compound lenses with non-spherical faces with discontinuous faces, e.g. Fresnel lens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/18—Diffraction gratings
    • G02B5/1876—Diffractive Fresnel lenses; Zone plates; Kinoforms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/18—Diffraction gratings
    • G02B5/1876—Diffractive Fresnel lenses; Zone plates; Kinoforms
    • G02B5/189—Structurally combined with optical elements not having diffractive power
    • G02B5/1895—Structurally combined with optical elements not having diffractive power such optical elements having dioptric power
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
    • G02C2202/10—Optical elements and systems for visual disorders other than refractive errors, low vision
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
    • G02C2202/20—Diffractive and Fresnel lenses or lens portions
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
    • G02C2202/24—Myopia progression prevention

Definitions

  • the present invention relates to a method of optical treatment.
  • the present invention relates to a method for treating progression of refractive disorders, such as myopia and hyperopia, in human eyes.
  • the retina is the innermost layer of an eyeball and is the place where optical images created by the lens of the eye is focused.
  • the information from the images are turned into nerve impulses, which are then sent to the brain via the optic nerve. If the retina does not coincide with the resultant focal point of the optical elements of the eye, defocus is generated.
  • the term "defocus” refers to the shift of the optical images to a point behind or in front of the retina.
  • the human eye has a feedback mechanism that regulates the growth of the eye to achieve an optimal balance between the size/length of the eye and the focal length of the optical elements of the eye. This feedback mechanism is called emmetropization. Myopia and hyperopia are common refractive disorders of human eyes.
  • an optical image 12 is formed in front of the retina in the case of myopia.
  • Defocus in this case is positive and called myopic defocus 13.
  • the emmetropization mechanism operates to retard eye growth in size until the retina 11 coincides with the optical image 12 when the myopic defocus 13 diminished. As a result, the eye becomes less myopic.
  • optical image 22 is formed behind the retina 21 in the case of hyperopia.
  • Defocus in this form is negative and called hyperopic defocus 23.
  • the emmetropization mechanism operates to promote eye growth in size until the retina 21 coincides with the optical image 22 when the hyperopic defocus 23 diminished. As a result, the eye becomes less hyperopic.
  • the natural major sources of defocus for a human eye come from accommodation lag arid ambient defocus.
  • the accommodation lag is generally projected by the object of interest 35 onto the center of the retina 31 or macula 34 along a visual axis 32.
  • hyperopic defocus 36 It usually ranges from 0.5D to 1.0D of hyperopic defocus 36 for a non-presbyope during near visual tasks, such as reading.
  • Ambient defocus is projected by peripheral visual objects other than the object of interest 35. Since peripheral objects are usually positioned more distant than the object of interest 35, they usually produce myopic defocus up to 3.0D during near visual tasks. For example, peripheral object 37 produce myopic defocus 38 at periphery of retina 31. Habitually, the peripheral visual objects are seldom positioned closer than the object of interest 35. However, if they do like peripheral object 39, hyperopic defocus 33 will be produced.
  • the natural process of emmetropization is regulated by the equilibrium between the above opposite defocus. Incidences of refractive errors are secondary to the disruption of the equilibrium. For example, insufficient ambient myopic defocus may cause myopia. On the other hand, excessive ambient myopic defocus may cause hyperopia.
  • the present invention is directed to a method fox treating progression of a refractive disorder in a human eye.
  • the present invention provides methods for counteracting the development of myopia by enhancing myopic defocus.
  • the present invention also provides methods for counteracting the development of hyperopia by enhancing hyperopic defocus.
  • the apparatuses used in practice of the present invention alter the defocus equilibrium of the eye to influence axial eye growth in a direction towards emmetropic ⁇
  • the method for treating progression of a refractive disorder in a human eye includes producing a first image on a retina of the human eye and producing a second image to generate a defocus.
  • the method for treating progression of a refractive disorder in a human eye inclttdes providing a Fresnel lens having primary optical zones and secondary optical zones.
  • T ⁇ ie primary optical zones include a primary refractive power
  • secondary optical zone includes at least one secondary refractive power.
  • the method also includes correcting the refractive disorder with the primary refractive power and generating at least one defocus with the secondary refractive power.
  • the method for treating progression of a refractive disorder in a human eye includes prescribing an optical system having a back layer and a partially transparent front layer. The method also includes producing a primary image of one of the front and back layers on a retina of the human eye and producing a secondary image of the other layer of the front and back layers to geneorate a defocus.
  • the method for treating progression of a refractive disorder in a human eye includes providing a lens including a central optical zone having a primary optical power and at least one peripheral optical zone having a secondary optical power. The method also includes producing a primary image on a retina of the human eye with the first optical power and producing at least one secondary image with the second optical power to generate a defocus.
  • the method for treating progression of a refractive disorder in a human eye includes prescribing an optical system having a central visual object and at least one peripheral visual object.
  • the method also includes producing a first image of the central visual object on a central retina of the human eye and producing a second image of the peripheral visual object to generate a defocus.
  • HGl is a schematic diagram showing the section of a myopic eye and the nature of myopic defocus.
  • FIG.2 is a schematic diagram showing the section of a hyperopic eye and the nature of hyperopic defocus.
  • FIG3 is schematic diagram showing the section of an eye, illustrating the source and the formation of accommodation lag and ambient defocus.
  • FIG4a is a cross-sectional view of a Fresnel type concentric bi-focal or multi-focal lens used in practice of the present invention.
  • FIG.4b is a back view of the Fresnel type concentric bi-focal or multi-focal lens of
  • FIG5a is a diagram of a myopic eye fitted with a concentric bi-focal lens in accordance with the present invention.
  • FIG5b is a diagram of a myopic eye fitted with a concentric multi-focal lens in accordance with the present invention.
  • FIG.6a is a diagram of a hyperopic eye fitted with a concentric bi-focal lens in accordance with the present invention.
  • FIG.6b is a diagram of a hyperopic eye fitted with a concentric multi-focal lens in accordance with the present invention.
  • FIG7a is a diagram of a myopic eye fitted with an optical system having of a semi-transparent front layer and a non-transparent back layer in accordance with the present invention.
  • FIG.7b is a diagram of a hyperopic eye fitted with an optical system having a non-transparent back layer and a semi-transparent front layer in accordance with the present invention.
  • FIG8a is a cross-sectional view of a central-peripheral multi-focal lens used in practice of the present invention.
  • FIG.8b is a back view of the central-peripheral multi-focal lens of FIG. 8a.
  • FIG.9 is a diagram of a myopic eye fitted with the central-peripheral multi-focal lens of FIG. 8a and FIG. 8b in accordance with the present invention.
  • FIGlO is a diagram of a hyperopia eye fitted with the central-peripheral multi-focal lens of FIG. 8a and FIG. 8b in accordance with the present invention.
  • FIGlIa is a diagram of a myopic eye fitted with an optical system having peripheral visual objects positioned closer than a central visual object in accordance with the present invention.
  • FIGlIb is a diagram of a hyperopic eye fitted with an optical system having peripheral visual objects positioned closer than a central visual object in accordance with the present invention.
  • the present invention is directed to a method for treating progression of a refractive disorder in a human eye.
  • the present invention provides a method for counteracting the development of myopia by enhancing myopic defocus.
  • the present invention also provides a method for counteracting the development of hyperopia by enhancing of hyperopic defocus.
  • the apparatuses used in practice of the present invention alter the defocus equilibrium of the eye to influence axial eye growth in a direction towards emmetropia.
  • the artificial shift of the defocus equilibrium in the optical system of the eye may be introduced by any desired method, for example by spectacle lens, spectacle lens add-on, contact lens, corneal shape-modification, ocular implant or designated viewing system. It is preferred that the shift be introduced together with the conventional correction so that normal vision can be maintained throughout the treatment. This means that a focused image must be maintained near the macula 34, while one or more defocused images are being introduced into the optical system of the eye.
  • a treatment method in accordance with the present invention introduces at least a defocused image and a focused image in a superimposed manner.
  • the defocused and focused images can be introduced simultaneously, for example, by a concentric Fresnel type bi-focal or multi-focal lens as shown in FIGS. 4-6, diffractive multi-focal lens and their derivatives, or an optical system as shown in FIG. 7.
  • the Fresnel concentric bi-focal or multi-focal lens having alternating concentric optic zones 41 and 42 of at least two refractive powers used in practice of the present invention.
  • a common way to manufacture the Fresnel concentric bi-focal lens is to make one of the surfaces with two radius of curvature.
  • the zone 42 with a shorter radius of curvature (i.e. more curved) than the other zone 41 with a longer radius of curvature (i.e. flatter) exhibits a more negative refractive power.
  • the zone with a more negative power 44 and the zone with a less negative power 43 alternate in a concentric manner.
  • paraxial light rays and peripheral light rays share two common focal points.
  • FIG. 5a shows a myopic eye fitted with a Fresnel type concentric bi-focal lens 50 having a primary refractive power correcting the myopia and a secondary power to introduce myopic defocus in accordance with the present invention.
  • Light rays 51 entering the optical zones having the primary power are focused on the retina 52, producing a sharp image of a visual object.
  • other light rays 53 entering the optical zones having the secondary power are focused at a point 54 in front of the retina 52, producing the myopic defocus 55.
  • the myopic defocus 55 prevents the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
  • FIG. 6a shows a hyperopic eye fitted with a Fresnel type concentric bi-focal lens 60 having a primary refractive power to correct the hyperopia and a secondary power to introduce hyperopic defocus.
  • Light rays 61 entering the optical zones having the primary power are focused onto the retina 62, producing a sharp image of a visual object.
  • a Fresnel type of concentric multi-focal lens is a derivative of the Fresnel type concentric bi-focal lens. It has alternating concentric optic zones of more than two refractive powers. The primary refractive power corrects the refractive error, while the multiple secondary powers introduce optical defocus for treatment.
  • FIG.5b shows a myopic eye fitted with a Fresnel type concentric multi-focal lens 56 in accordance with the present invention.
  • Light rays 51 entering the optical zones having the primary power are focused on the retina 52, producing a sharp image of a visual object.
  • other light rays 53 entering the optical zones having the secondary powers are focused at points 57 in front of the retina 52, producing multiple myopic defocus 58 of various amplitudes.
  • the myopic defocus 58 prevent the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
  • FIG. 6b shows a hyperopic eye fitted with a Fresnel type concentric multi-focal lens
  • FIG. 7a shows a myopic eye fitted with an optical system having a primary semi-transparent front layer 71 and a secondary non-transparent back layer 73 in accordance with the present invention.
  • the front layer 71 matches the focal point of the eye, producing a sharp image 72 on the retina.
  • the back layer 73 produces an image 74 in front of the retina causing a myopic defocus 75 superimposed on the sharp image 72.
  • the myopic defocus 75 prevents the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
  • FIG. 7b shows a hyperopic eye fitted with an optical system having a primary non-transparent back layer 76 and a secondary semi-transparent front layer 78 in accordance with the present invention.
  • the back layer 16 matches the focal point of the eye, producing a sharp image 77.
  • the front layer 78 produces an image 79 behind the retina causing a hyperopic defocus 80 superimposed on the sharp image 77.
  • the hyperopic defocus 80 promotes the eye in growing or elongating. Consequently, myopic progression in the hyperopic eye is increased or induced, and hyperopia is reduced.
  • the optical quality of the retinal image produced by the primary components can be strengthened over the image produced by the secondary components. This can be achieved by manipulating the area ratio between the different zones of the Fresnel lenses and manipulating the transmission proportion of the semi-transparent layers.
  • An alternative method in accordance with the present invention introduces defocused image at peripheral retina only and keeps focused image at central retina. People habitually maintain a sharp image at central retina by a voluntary fixation reflex.
  • the way to simultaneously present two images is the introduction of the defocus image at peripheral retina through the use of a central-peripheral multi-focal lens as shown in FIGS. 8-10 and a optical system as shown in FIG. 11.
  • the central-peripheral multi-focal lens includes concentric optical zones of two or more optical powers.
  • One way to manufacture this kind of lens is to generate the zones with materials of different refractive index.
  • the central zone 81 which has a higher refractive index than the peripheral zone 82, exhibits higher refractive power.
  • the two zones 81 and 82 are positioned in a generally concentric manner, with the refractive power decreasing from the central towards the peripheral across the lens. The transition can be subtle or progressive, depending on the manufacturing process.
  • FIG. 9 shows a myopic eye fitted with a negative central-peripheral multi-focal lens, which has a primary central refractive power correcting the myopia and a secondary peripheral refractive power to introduce myopic defocus, in accordance with the present invention.
  • Light rays entering the central zone of the lens from a central visual objects 91 are focused onto the central retina, producing a corresponding central sharp image 92.
  • light rays entering the peripheral zone of the lens from the peripheral visual objects 93 are focused at points in front of the peripheral retina, producing the peripheral myopic defocus 94 required for the treatment effect for myopia.
  • the myopic defocus 94 prevents the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
  • FIG 10 shows a hyperopic eye fitted with a positive central-peripheral multi-focal lens, which have a primary central refractive power correcting the hyperopia and a secondary peripheral refractive power to introduce hyperopic defocus, in accordance with the present invention.
  • Light rays entering the central zone of the lens from the central visual objects 101 are focused onto the central retina, producing a corresponding central sharp image 102.
  • light rays entering the peripheral zone of the lens from the peripheral visual objects 103 are focused at points behind the peripheral retina, producing the peripheral hyperopic defocus 104 required for the treatment effect for hyperopia.
  • the hyperopic defocus 104 promotes the eye in growing or elongating. Consequently, myopic progression in the hyperopic eye is increased or induced, and hyperopia is reduced.
  • FIG. 11a shows a myopic eye fitted with a pre-designed visual environment or an optical system, which has peripheral visual objects 113 positioned far away from the eye compared with the central visual object 111, in accordance with the present invention.
  • Light rays from the central object 111 as directed by basic optics and the fixation reflex of the eye, are focused onto the central retina, producing a corresponding central sharp image 112.
  • peripheral myopic defocus 114 required for the treatment of myopia.
  • the myopic defocus 114 prevents the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
  • FIG. lib shows a hyperopic eye fitted with a pre-designed visual environment or an optical system, which has peripheral visual objects 117 positioned close to the eye compared with the central visual object 115.
  • Light rays from the central object 115 as directed by basic optics and the fixation reflex of the eye, are focused onto the central retina producing a corresponding central sharp image 116.
  • light rays from peripheral visual objects 117 are focused at points behind the peripheral retina, producing peripheral hyperopic defocus 118 required for the treatment of hyperopia.
  • the hyperopic defocus 118 promotes the eye in growing or elongating. Consequently, myopic progression in the hyperopic eye is increased or induced, and hyperopia is reduced.
  • the present invention has particular applications in curing and preventing the progression of refractive disorders of the eye such as myopia and hyperopia, it is to be understood that the invention could be used in other applications such as the prevention of pathological myopic degeneration of the eye.

Abstract

A method for treating progression of a refractive disorder in a human eye. The method includes the steps of producing a first image on a retina of the human eye and producing a second image to generate a defocus.

Description

METHOD OFOPTICALTREATMENT
HELD OF THE INVENTION
The present invention relates to a method of optical treatment. In particular, the present invention relates to a method for treating progression of refractive disorders, such as myopia and hyperopia, in human eyes.
BACKGROUND OFTHEINVENTION
The retina is the innermost layer of an eyeball and is the place where optical images created by the lens of the eye is focused. The information from the images are turned into nerve impulses, which are then sent to the brain via the optic nerve. If the retina does not coincide with the resultant focal point of the optical elements of the eye, defocus is generated. As used herein, the term "defocus" refers to the shift of the optical images to a point behind or in front of the retina. The human eye has a feedback mechanism that regulates the growth of the eye to achieve an optimal balance between the size/length of the eye and the focal length of the optical elements of the eye. This feedback mechanism is called emmetropization. Myopia and hyperopia are common refractive disorders of human eyes. They are generally described as an imbalance between the focusing power of optical elements of the eye and the size/length of the eye. Focus of a myopic eye lies in front of the retina of the eye, while focus of a hyperopia eye lies behind the retina of the eye. It is generally accepted that these disorders are results of inaccurate axial growth during post-natal development of the eyes. In other words, myopia typically develops when the size/length of the eye grows to exceed the focal length of the optical elements of the eye, while hyperopia typically develops when the size/length of the eye grows to be shorter than the focal length of the optical elements of the eye.
Referring to FIG. 1, an optical image 12 is formed in front of the retina in the case of myopia. Defocus in this case is positive and called myopic defocus 13. The emmetropization mechanism operates to retard eye growth in size until the retina 11 coincides with the optical image 12 when the myopic defocus 13 diminished. As a result, the eye becomes less myopic.
Referring to FTG. 2, optical image 22 is formed behind the retina 21 in the case of hyperopia. Defocus in this form is negative and called hyperopic defocus 23. The emmetropization mechanism operates to promote eye growth in size until the retina 21 coincides with the optical image 22 when the hyperopic defocus 23 diminished. As a result, the eye becomes less hyperopic.
Referring to FIG. 3, the natural major sources of defocus for a human eye come from accommodation lag arid ambient defocus. The accommodation lag is generally projected by the object of interest 35 onto the center of the retina 31 or macula 34 along a visual axis 32.
It usually ranges from 0.5D to 1.0D of hyperopic defocus 36 for a non-presbyope during near visual tasks, such as reading. Ambient defocus is projected by peripheral visual objects other than the object of interest 35. Since peripheral objects are usually positioned more distant than the object of interest 35, they usually produce myopic defocus up to 3.0D during near visual tasks. For example, peripheral object 37 produce myopic defocus 38 at periphery of retina 31. Habitually, the peripheral visual objects are seldom positioned closer than the object of interest 35. However, if they do like peripheral object 39, hyperopic defocus 33 will be produced.
The natural process of emmetropization is regulated by the equilibrium between the above opposite defocus. Incidences of refractive errors are secondary to the disruption of the equilibrium. For example, insufficient ambient myopic defocus may cause myopia. On the other hand, excessive ambient myopic defocus may cause hyperopia.
Existing optical aids and refractive surgeries, in the form of spectacles, contact lens, corneal implant or shape modification of cornea, are corrective approaches involving alteration of the gross focusing power of the eye to produce sharper retinal images. They do not eliminate or deal with the cause of the disorders, bat are just prosthetic.
The existing optical treatments to retard the progression of myopia by relieving the eye's accommodation during near visual tasks are recently shown to be clinically ineffective. Examples, of those treatments include bi-focal addition lenses, multi-focal progressive addition lenses'and'their derivatives, and spherical aberration manipulations.
SUMMARY OF THE INVENTION
The present invention is directed to a method fox treating progression of a refractive disorder in a human eye. Particularly, the present invention provides methods for counteracting the development of myopia by enhancing myopic defocus. The present invention also provides methods for counteracting the development of hyperopia by enhancing hyperopic defocus. The apparatuses used in practice of the present invention alter the defocus equilibrium of the eye to influence axial eye growth in a direction towards emmetropic ■ According to a general aspect of the present invention, the method for treating progression of a refractive disorder in a human eye includes producing a first image on a retina of the human eye and producing a second image to generate a defocus.
According to one aspect of the present invention, the method for treating progression of a refractive disorder in a human eye inclttdes providing a Fresnel lens having primary optical zones and secondary optical zones. Tϊie primary optical zones include a primary refractive power, and secondary optical zone includes at least one secondary refractive power. The method also includes correcting the refractive disorder with the primary refractive power and generating at least one defocus with the secondary refractive power.
According to another aspect of the present invention, the method for treating progression of a refractive disorder in a human eye includes prescribing an optical system having a back layer and a partially transparent front layer. The method also includes producing a primary image of one of the front and back layers on a retina of the human eye and producing a secondary image of the other layer of the front and back layers to geneorate a defocus. According to yet another aspect of the present invention, the method for treating progression of a refractive disorder in a human eye includes providing a lens including a central optical zone having a primary optical power and at least one peripheral optical zone having a secondary optical power. The method also includes producing a primary image on a retina of the human eye with the first optical power and producing at least one secondary image with the second optical power to generate a defocus.
According to yet another aspect of the present invention, the method for treating progression of a refractive disorder in a human eye includes prescribing an optical system having a central visual object and at least one peripheral visual object. The method also includes producing a first image of the central visual object on a central retina of the human eye and producing a second image of the peripheral visual object to generate a defocus.
BRIEF DESCRIPTION OF THE DRAWINGS
HGl is a schematic diagram showing the section of a myopic eye and the nature of myopic defocus. FIG.2 is a schematic diagram showing the section of a hyperopic eye and the nature of hyperopic defocus. FIG3 is schematic diagram showing the section of an eye, illustrating the source and the formation of accommodation lag and ambient defocus.
FIG4a is a cross-sectional view of a Fresnel type concentric bi-focal or multi-focal lens used in practice of the present invention. FIG.4b is a back view of the Fresnel type concentric bi-focal or multi-focal lens of
HG. 4a.
FIG5a is a diagram of a myopic eye fitted with a concentric bi-focal lens in accordance with the present invention.
FIG5b is a diagram of a myopic eye fitted with a concentric multi-focal lens in accordance with the present invention.
FIG.6a is a diagram of a hyperopic eye fitted with a concentric bi-focal lens in accordance with the present invention.
FIG.6b is a diagram of a hyperopic eye fitted with a concentric multi-focal lens in accordance with the present invention. FIG7a is a diagram of a myopic eye fitted with an optical system having of a semi-transparent front layer and a non-transparent back layer in accordance with the present invention.
FIG.7b is a diagram of a hyperopic eye fitted with an optical system having a non-transparent back layer and a semi-transparent front layer in accordance with the present invention.
FIG8a is a cross-sectional view of a central-peripheral multi-focal lens used in practice of the present invention.
FIG.8b is a back view of the central-peripheral multi-focal lens of FIG. 8a. FIG.9 is a diagram of a myopic eye fitted with the central-peripheral multi-focal lens of FIG. 8a and FIG. 8b in accordance with the present invention. FIGlO is a diagram of a hyperopia eye fitted with the central-peripheral multi-focal lens of FIG. 8a and FIG. 8b in accordance with the present invention.
FIGlIa is a diagram of a myopic eye fitted with an optical system having peripheral visual objects positioned closer than a central visual object in accordance with the present invention.
FIGlIb is a diagram of a hyperopic eye fitted with an optical system having peripheral visual objects positioned closer than a central visual object in accordance with the present invention.
DETAILED DESCRIPTION OF THE INVENTION
The present invention is directed to a method for treating progression of a refractive disorder in a human eye. Particularly, the present invention provides a method for counteracting the development of myopia by enhancing myopic defocus. The present invention also provides a method for counteracting the development of hyperopia by enhancing of hyperopic defocus. The apparatuses used in practice of the present invention alter the defocus equilibrium of the eye to influence axial eye growth in a direction towards emmetropia.
The artificial shift of the defocus equilibrium in the optical system of the eye may be introduced by any desired method, for example by spectacle lens, spectacle lens add-on, contact lens, corneal shape-modification, ocular implant or designated viewing system. It is preferred that the shift be introduced together with the conventional correction so that normal vision can be maintained throughout the treatment. This means that a focused image must be maintained near the macula 34, while one or more defocused images are being introduced into the optical system of the eye. A treatment method in accordance with the present invention introduces at least a defocused image and a focused image in a superimposed manner. The defocused and focused images can be introduced simultaneously, for example, by a concentric Fresnel type bi-focal or multi-focal lens as shown in FIGS. 4-6, diffractive multi-focal lens and their derivatives, or an optical system as shown in FIG. 7.
Referring now FIG 4a and 4b, there shown is the Fresnel concentric bi-focal or multi-focal lens having alternating concentric optic zones 41 and 42 of at least two refractive powers used in practice of the present invention. A common way to manufacture the Fresnel concentric bi-focal lens is to make one of the surfaces with two radius of curvature. For example, the zone 42 with a shorter radius of curvature (i.e. more curved) than the other zone 41 with a longer radius of curvature (i.e. flatter) exhibits a more negative refractive power. The zone with a more negative power 44 and the zone with a less negative power 43 alternate in a concentric manner. As a result, paraxial light rays and peripheral light rays share two common focal points.
FIG. 5a shows a myopic eye fitted with a Fresnel type concentric bi-focal lens 50 having a primary refractive power correcting the myopia and a secondary power to introduce myopic defocus in accordance with the present invention. Light rays 51 entering the optical zones having the primary power are focused on the retina 52, producing a sharp image of a visual object. At the same time, other light rays 53 entering the optical zones having the secondary power are focused at a point 54 in front of the retina 52, producing the myopic defocus 55. When a myopic patient uses the lens 50 to view an object, the myopic defocus 55 prevents the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
FIG. 6a shows a hyperopic eye fitted with a Fresnel type concentric bi-focal lens 60 having a primary refractive power to correct the hyperopia and a secondary power to introduce hyperopic defocus. Light rays 61 entering the optical zones having the primary power are focused onto the retina 62, producing a sharp image of a visual object.
Simultaneously, other light rays 63 entering the optical zones having the secondary power are focused at a point 64 behind the retina 62, producing the hyperopic defocus 65. When a hyperopia patient uses the lens 60 to view an object, the hyperopic defocus 65 promots the eye in growing or elongating. Consequently, myopic progression in the hyperopic eye is increased or induced, and hyperopia is reduced. A Fresnel type of concentric multi-focal lens is a derivative of the Fresnel type concentric bi-focal lens. It has alternating concentric optic zones of more than two refractive powers. The primary refractive power corrects the refractive error, while the multiple secondary powers introduce optical defocus for treatment. This can be achieved by a minor variation on the radius of curvature of the secondary optical zones. FIG.5b shows a myopic eye fitted with a Fresnel type concentric multi-focal lens 56 in accordance with the present invention. Light rays 51 entering the optical zones having the primary power are focused on the retina 52, producing a sharp image of a visual object. At the same time, other light rays 53 entering the optical zones having the secondary powers are focused at points 57 in front of the retina 52, producing multiple myopic defocus 58 of various amplitudes. When a myopic patient uses the lens 56 to view an object, the myopic defocus 58 prevent the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
FIG. 6b shows a hyperopic eye fitted with a Fresnel type concentric multi-focal lens
66. Light rays 61 entering the optical zones having the primary power are focused onto the retina 62, producing a sharp image of a visual object. Simultaneously, other light rays 63 entering the optical zones having the secondary powers are focused at points 61 behind the retina 62, producing multiple hyperopic defocus 68 of various amplitudes. When a hyperopic patient uses the lens 66 to view an object, the hyperopic defocus 68 promotes the eye in growing or elongating. Consequently, myopic progression in the hyperopic eye is increased or induced, and hyperopia is reduced. FIG. 7a shows a myopic eye fitted with an optical system having a primary semi-transparent front layer 71 and a secondary non-transparent back layer 73 in accordance with the present invention. The front layer 71 matches the focal point of the eye, producing a sharp image 72 on the retina. At the same time, the back layer 73 produces an image 74 in front of the retina causing a myopic defocus 75 superimposed on the sharp image 72. When a myopic patient uses this optical system, the myopic defocus 75 prevents the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
FIG. 7b shows a hyperopic eye fitted with an optical system having a primary non-transparent back layer 76 and a secondary semi-transparent front layer 78 in accordance with the present invention. The back layer 16 matches the focal point of the eye, producing a sharp image 77. In the same time, the front layer 78 produces an image 79 behind the retina causing a hyperopic defocus 80 superimposed on the sharp image 77. When a hyperopic patient uses this optical system, the hyperopic defocus 80 promotes the eye in growing or elongating. Consequently, myopic progression in the hyperopic eye is increased or induced, and hyperopia is reduced.
To improve the visual performance produced by the treatment methods and to avoid the user from mixing up his or her primary and secondary optical components, the optical quality of the retinal image produced by the primary components can be strengthened over the image produced by the secondary components. This can be achieved by manipulating the area ratio between the different zones of the Fresnel lenses and manipulating the transmission proportion of the semi-transparent layers.
An alternative method in accordance with the present invention introduces defocused image at peripheral retina only and keeps focused image at central retina. People habitually maintain a sharp image at central retina by a voluntary fixation reflex.
Accordingly, the way to simultaneously present two images is the introduction of the defocus image at peripheral retina through the use of a central-peripheral multi-focal lens as shown in FIGS. 8-10 and a optical system as shown in FIG. 11.
As shown in FIGS. 8a and 8b, the central-peripheral multi-focal lens includes concentric optical zones of two or more optical powers. One way to manufacture this kind of lens is to generate the zones with materials of different refractive index. The central zone 81, which has a higher refractive index than the peripheral zone 82, exhibits higher refractive power. The two zones 81 and 82 are positioned in a generally concentric manner, with the refractive power decreasing from the central towards the peripheral across the lens. The transition can be subtle or progressive, depending on the manufacturing process. FIG. 9 shows a myopic eye fitted with a negative central-peripheral multi-focal lens, which has a primary central refractive power correcting the myopia and a secondary peripheral refractive power to introduce myopic defocus, in accordance with the present invention. Light rays entering the central zone of the lens from a central visual objects 91 are focused onto the central retina, producing a corresponding central sharp image 92. Simultaneously, light rays entering the peripheral zone of the lens from the peripheral visual objects 93 are focused at points in front of the peripheral retina, producing the peripheral myopic defocus 94 required for the treatment effect for myopia. When a myopic patient uses the lens to view the visual objects 91 and 93, the myopic defocus 94 prevents the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
FIG 10 shows a hyperopic eye fitted with a positive central-peripheral multi-focal lens, which have a primary central refractive power correcting the hyperopia and a secondary peripheral refractive power to introduce hyperopic defocus, in accordance with the present invention. Light rays entering the central zone of the lens from the central visual objects 101 are focused onto the central retina, producing a corresponding central sharp image 102. Simultaneously, light rays entering the peripheral zone of the lens from the peripheral visual objects 103 are focused at points behind the peripheral retina, producing the peripheral hyperopic defocus 104 required for the treatment effect for hyperopia. When a hyperopic patient uses this optical system, the hyperopic defocus 104 promotes the eye in growing or elongating. Consequently, myopic progression in the hyperopic eye is increased or induced, and hyperopia is reduced.
FIG. 11a shows a myopic eye fitted with a pre-designed visual environment or an optical system, which has peripheral visual objects 113 positioned far away from the eye compared with the central visual object 111, in accordance with the present invention. Light rays from the central object 111 , as directed by basic optics and the fixation reflex of the eye, are focused onto the central retina, producing a corresponding central sharp image 112.
Simultaneously, light rays from peripheral visual objects 113 are focused at points in front of the peripheral retina, producing peripheral myopic defocus 114 required for the treatment of myopia. When a myopic patient uses this optical system, the myopic defocus 114 prevents the eye from growing or elongating. Consequently, myopic progression in the myopic eye is slowed, stopped or reversed.
FIG. lib shows a hyperopic eye fitted with a pre-designed visual environment or an optical system, which has peripheral visual objects 117 positioned close to the eye compared with the central visual object 115. Light rays from the central object 115, as directed by basic optics and the fixation reflex of the eye, are focused onto the central retina producing a corresponding central sharp image 116. Simultaneously, light rays from peripheral visual objects 117 are focused at points behind the peripheral retina, producing peripheral hyperopic defocus 118 required for the treatment of hyperopia. When a hyperopic patient uses this optical system, the hyperopic defocus 118 promotes the eye in growing or elongating. Consequently, myopic progression in the hyperopic eye is increased or induced, and hyperopia is reduced. Although the present invention has particular applications in curing and preventing the progression of refractive disorders of the eye such as myopia and hyperopia, it is to be understood that the invention could be used in other applications such as the prevention of pathological myopic degeneration of the eye.
Although the present invention has been described with reference to preferred methods, workers skilled in the art will recognize that changes may be made in form and detail without departing from the spirit and scope of the invention. In addition, the invention is not to be taken as limited to all of the details thereof as modifications and variations thereof may be made without departing from the spirit or scope of the invention.

Claims

CLAIMS We claim:
1. A method for treating progression of a refractive disorder in a human eye comprising: (a) providing a Fresnel lens comprising primary optical zones having a primary refractive power and secondary optical zones having at least one secondary refractive power; and (b) correcting the refractive disorder with the primary refractive power and generating at least one defocus with the secondary refractive power.
2. The method of claim 1, wherein: the refractive disorder in a human eye comprises myopia; and the step (b) comprises focusing a first stream of light rays of an object onto a retina of the human eye through the primary optical zones to correct the myopia and focusing a second stream of light rays of the object in front of the retina through the secondary optical zones to generate at least one myopic defocus.
3. The method of claim 1, wherein: the refractive disorder in a human eye comprises hyperopia; and the step (b) comprises focusing a primary stream of light rays of an object onto a retina of the human eye through the first optical zones to correct the hyperopia and focusing a second stream of light rays of the object behind the retina through the secondary optical zones to generate at least one hyperopia defocus.
4. The method of claim 1, wherein the step (a) comprises providing a Fresnel concentric bi-focal lens to produce a defocus in step (b) .
5. The method of claim 1, wherein the step (a) comprises providing a Fresnel concentric multi-focal lens producing two or more defocuses in step (b).
6. A method for treating progression of a refractive disorder in a human eye comprising: (a) providing an optical system having a back layer and a partially transparent front layer; and (b) producing a primary image of one of the front and back layers on a retina of the human eye and producing a secondary image of the other layer of the front and back layers to generate a defocus.
7. The method of 6 wherein: the refractive disorder in a human eye comprises myopia; and the step (b) comprises producing the primary image of the partially transparent front layer on the retina and producing the secondary image of the back layer in front of the retina to generate a myopic defocus.
8. The method of 6 wherein: the refractive disorder in a human eye comprises hyperopia; and the step (b) comprises producing the primary image of the back layer on the retina and producing the secondary image of the partially transparent front layer behind the retina to generate a hyperopic defocus.
9. A method for treating progression of a refractive disorder ixi a human eye comprising:
(a) providing a lens including a central optical zone having a primary optical power and at least one peripheral optical zone having a secondary optical power; and
(b) producing a primary image on a retina of the human eye with the first optical power and producing at least one secondary image with trie second optical power to generate a defocus.
10. The method of 9 wherein: the refractive disorder in a human eye comprises myopia; and the step (b) comprises focusing a light stream of a central visual object onto the retina of the human eye through the central optical zone and focusing a light stream of a peripheral visual object in front of the retina through the peripheral optical zone to generate a myopic defocus.
11. The method of 9 wherein: the refractive disorder in a human eye comprises hyperopia; and the step (b) comprises focusing a light stream of a central visual object onto the retina of the human eye through the central optical zone and focusing a light stream of a peripheral visual object behind the retina through the peripheral optical zone to generate a hyperopic defocus.
12. A method for treating progression of a refractive disorder in a human eye comprising:
(a) providing an optical system having a central visual object and at least one peripheral visual object; and
(b) producing a first image of the central visual object on a central retina of the- human eye and producing a second image of the peripheral visual object to generate a defocus.
13. The method of 12 wherein: the refractive disorder in a human eye comprises myopia; and producing a second image of the peripheral visual object to generate a defocus of the step (b) comprises producing the second image of the peripheral visual object in front of the peripheral retina of the human eye to generate a myopic defocus.
14. The method of 12 wherein: the refractive disorder in a human eye comprises hyperopia; and producing a second image of the peripheral visual object to generate a defocus of the step (b) comprises producing the second image of the peripheral visual object behind the peripheral retina of the human eye to generate a hyperopic defocus.
15. A method for treating progression of a refractive disorder in a human eye compri sing:
(a) producing a first image on a retina of the human eye; and
(b) producing a second image to generate a defocus.
16. The method of claim 15, wherein: the refractive disorder in a human eye comprises myopia; and the step (b) comprises producing the second image in front of the retina of the human eye to generate a myopic defocus.
17. The method of claim 15, wherein: the refractive disorder in a human eye comprises hyperopia; and the step (b) includes producing the second image behind the retina of the human eye to generate a hyperopic defocus.
PCT/CN2005/001605 2004-09-30 2005-09-29 Method of optical treatment WO2006034652A1 (en)

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JP2007533857A JP4891249B2 (en) 2004-09-30 2005-09-29 Optical therapy method
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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2084568A2 (en) * 2006-10-10 2009-08-05 Novartis AG A lens having an optically controlled peripheral portion and a method for designing and manufacturing the lens
DE102009053467A1 (en) 2008-11-14 2010-07-08 Rodenstock Gmbh Spectacles glass for e.g. preventing progression of myopia, has peripheral view regions with refractive power, which is partially changed from central view region in horizontal direction towards right and left edges of glass to same sign
US7766478B2 (en) 2004-07-01 2010-08-03 Auckland Uniservices Limited Contact lens and method for prevention of myopia progression
JP2010526563A (en) * 2007-04-27 2010-08-05 ザ インスティチュート フォー アイ リサーチ リミテッド Determination of visual acuity adjustment to delay the progression of myopia
US7832859B2 (en) 2007-03-09 2010-11-16 Auckland Uniservices Limited Contact lens and method
AU2009330163B2 (en) * 2008-12-22 2014-05-01 The Medical College Of Wisconsin, Inc. Method and apparatus for limiting growth of eye length
WO2014084411A1 (en) * 2012-11-30 2014-06-05 Essilor International Fresnel lens and optical device
US8950860B2 (en) 2010-09-09 2015-02-10 The Hong Kong Polytechnic University Method and system for retarding the progression of myopia
US10884264B2 (en) 2018-01-30 2021-01-05 Sightglass Vision, Inc. Ophthalmic lenses with light scattering for treating myopia
EP3812142A1 (en) 2019-10-23 2021-04-28 Carl Zeiss Vision International GmbH Method for producing a spectacle lens and a product comprising a spectacle lens
EP2616876B1 (en) 2010-09-13 2021-06-23 The Hong Kong Polytechnic University System for retarding progression of myopia
WO2022038581A1 (en) * 2020-08-21 2022-02-24 Brien Holden Vision Institute Limited Ophthalmic devices, systems and/or methods for management of ocular conditions and/or reducing night vision disturbances
EP3988290A1 (en) 2020-10-23 2022-04-27 Carl Zeiss Vision International GmbH Method for manufacturing a spectacle lens
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US11353721B2 (en) 2018-03-01 2022-06-07 Essilor International Lens element
US11378818B2 (en) 2018-03-01 2022-07-05 Essilor International Lens element
EP4089473A1 (en) 2021-05-10 2022-11-16 Carl Zeiss Vision International GmbH Spectacle lens design, spectacle lens kit, method of manufacturing a spectacle lens and method of providing a spectacle lens design
US11543681B2 (en) 2016-08-01 2023-01-03 University Of Washington Ophthalmic lenses for treating myopia
US11718052B2 (en) 2017-05-08 2023-08-08 Sightglass Vision, Inc. Contact lenses for reducing myopia and methods for making the same
EP4283382A1 (en) 2022-05-27 2023-11-29 Carl Zeiss Vision International GmbH Stiles-crawford-effect based mechanism and spectacle lens for retinal-region weighted prevention of myopia progression
US11927771B2 (en) 2014-06-05 2024-03-12 Optica Amuka (A.A.) Ltd. Control of dynamic lenses
US11953764B2 (en) 2017-07-10 2024-04-09 Optica Amuka (A.A.) Ltd. Tunable lenses with enhanced performance features

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2637053C (en) 2006-01-12 2014-02-25 Institute For Eye Research Method and apparatus for controlling peripheral image position for reducing progression of myopia
CN101467092B (en) 2006-06-08 2011-01-12 视力Crc有限公司 Means for controlling the progression of myopia
SG10201506615RA (en) * 2008-04-18 2015-10-29 Holden Brien Vision Inst Myopia control means
RU2544877C2 (en) * 2008-08-11 2015-03-20 Новартис Аг Lens design and method of preventing or slowing progression of myopia
EP2376976A1 (en) * 2008-12-19 2011-10-19 Novartis AG Correction of peripheral defocus of an eye and control of refractive error development
WO2011106838A1 (en) * 2010-03-03 2011-09-09 Brien Holden Vision Institute Contact lenses for myopic eyes and methods of treating myopia
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
WO2013015743A1 (en) * 2011-07-27 2013-01-31 National University Of Singapore Optical lens for slowing myopia progression
TWI588560B (en) 2012-04-05 2017-06-21 布萊恩荷登視覺協會 Lenses, devices, methods and systems for refractive error
US20140039361A1 (en) * 2012-08-06 2014-02-06 The Hong Kong Polytechnic University Methods and viewing systems for inhibiting ocular refractive disorders from progressing
US10231897B2 (en) 2012-08-06 2019-03-19 The Hong Kong Polytechnic University Methods, devices, and systems for inhibiting ocular refractive disorders from progressing
US9201250B2 (en) 2012-10-17 2015-12-01 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
KR102199677B1 (en) 2012-10-17 2021-01-08 브리엔 홀덴 비전 인스티튜트 리미티드 Lenses, devices, methods and systems for refractive error
SG10201400920RA (en) * 2014-03-24 2015-10-29 Menicon Singapore Pte Ltd Apparatus and methods for controlling axial growth with an ocular lens
CN111683629A (en) * 2017-12-11 2020-09-18 香港理工大学 Method, device and system for inhibiting progression of refractive error of an eye
US11789292B2 (en) 2018-01-22 2023-10-17 Johnson & Johnson Vision Care, Inc. Ophthalmic lens with an optically non-coaxial zone for myopia control
US10901237B2 (en) 2018-01-22 2021-01-26 Johnson & Johnson Vision Care, Inc. Ophthalmic lens with an optically non-coaxial zone for myopia control
US11768386B2 (en) 2018-01-22 2023-09-26 Johnson & Johnson Vision Care, Inc. Ophthalmic lens with an optically non-coaxial zone for myopia control
CN110221454A (en) * 2018-03-01 2019-09-10 依视路国际公司 Lens element
US20210263337A1 (en) * 2018-06-20 2021-08-26 Essilor International Lens element
JP2021529068A (en) 2018-07-07 2021-10-28 アキュセラ インコーポレイテッド Device to prevent retinal hypoxia
KR20210032529A (en) 2018-07-30 2021-03-24 어큐셀라 인코포레이티드 Optical design of electronic contact lenses to reduce myopia progression
CN109445127A (en) * 2018-11-16 2019-03-08 珠海博爱之光科技有限公司 A kind of optical treatment system for human eye
EP4003250A4 (en) 2019-07-31 2023-08-23 Acucela Inc. Device for projecting images on the retina
WO2021056018A1 (en) 2019-09-16 2021-03-25 Acucela Inc. Assembly process for an electronic soft contact lens designed to inhibit progression of myopia
US11777340B2 (en) 2020-02-21 2023-10-03 Acucela Inc. Charging case for electronic contact lens
US11754858B2 (en) 2020-04-30 2023-09-12 Coopervision International Limited Multifocal ophthalmic lens and related methods
US11762220B2 (en) 2020-04-30 2023-09-19 Coopervision International Limited Multifocal ophthalmic lenses and related methods
US11934043B2 (en) 2020-04-30 2024-03-19 Coopervision International Limited Myopia control lens and related methods
CA3177695A1 (en) 2020-05-13 2021-11-18 Ryo Kubota Electro-switchable spectacles for myopia treatment
US20230181030A1 (en) 2020-05-19 2023-06-15 Sightglass Vision, Inc. Ophthalmic lenses, methods of manufacturing the ophthalmic lenses, and methods of dispensing eye care products including the same
JP2023528307A (en) 2020-06-08 2023-07-04 アキュセラ インコーポレイテッド A patch-on device for treating progressive refractive error using peripheral defocusing
CN115698832A (en) 2020-06-08 2023-02-03 奥克塞拉有限公司 Asymmetric projection lens for treating astigmatism
CA3174148A1 (en) 2020-06-08 2021-12-16 Acucela Inc. Projection of defocused images on the peripheral retina to treat refractive error
US11281022B2 (en) 2020-06-10 2022-03-22 Acucela Inc. Apparatus and methods for the treatment of refractive error using active stimulation
CN111948823B (en) * 2020-08-21 2024-01-23 香港理工大学 Virtual reality equipment capable of inhibiting myopia deepening and optical path structure thereof
US11209672B1 (en) 2021-04-06 2021-12-28 Acucela Inc. Supporting pillars for encapsulating a flexible PCB within a soft hydrogel contact lens
US11366341B1 (en) 2021-05-04 2022-06-21 Acucela Inc. Electronic case for electronic spectacles
WO2023005211A1 (en) * 2021-07-28 2023-02-02 香港理工大学 Ring focus spectacle lens for controlling myopia progression, and manufacturing method therefor
WO2023114400A1 (en) 2021-12-15 2023-06-22 Sightglass Vision, Inc. Automated process for forming features on ophthalmic lens

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904281A (en) * 1969-12-08 1975-09-09 Optical Sciences Group Inc Flexible refracting membrane adhered to spectacle lens
US4210391A (en) * 1977-09-14 1980-07-01 Cohen Allen L Multifocal zone plate
WO1997010527A1 (en) * 1995-09-14 1997-03-20 The Regents Of The University Of California Structured index optics and ophthalmic lenses for vision correction
EP0927905A1 (en) * 1997-12-30 1999-07-07 Monique Mouflin Optical device for ambyopia
RU2195233C1 (en) * 2001-05-23 2002-12-27 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Method for treating nystagmus and amblyopia
RU2197198C2 (en) * 2000-02-15 2003-01-27 Булатов Юрий Павлович All-purpose means for correcting pathological disorders of vision organs

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162122A (en) * 1977-09-14 1979-07-24 Cohen Allen L Zonal bifocal contact lens
US4340283A (en) 1978-12-18 1982-07-20 Cohen Allen L Phase shift multifocal zone plate
US4338005A (en) 1978-12-18 1982-07-06 Cohen Allen L Multifocal phase place
DE3033458C2 (en) * 1980-09-05 1986-01-16 Frisch Kabel- Und Verseilmaschinenbau Gmbh, 4030 Ratingen Device for stranding strand-like material with stranding direction alternating in steps
DE3222099C2 (en) 1982-06-11 1984-06-20 Titmus Eurocon Kontaktlinsen Gmbh & Co Kg, 8750 Aschaffenburg Bifocal contact lens of the bivisual type
US4890913A (en) 1982-10-13 1990-01-02 Carle John T De Zoned multi-focal contact lens
DE3381691D1 (en) 1982-10-13 1990-08-02 Ng Trustees & Nominees Ltd BIFOCAL CONTACT LENSES.
EP0109753B1 (en) 1982-10-27 1988-07-27 Pilkington Plc Bifocal contact lens comprising a plurality of concentric zones
US4636049A (en) 1983-09-20 1987-01-13 University Optical Products Co. Concentric bifocal contact lens
US4752123A (en) 1985-11-19 1988-06-21 University Optical Products Co. Concentric bifocal contact lens with two distance power regions
GB8529006D0 (en) 1985-11-25 1986-01-02 Highgate D J Hydrophilic materials
US5144483A (en) 1986-05-14 1992-09-01 Cohen Allen L Diffractive multifocal optical device
US5017000A (en) 1986-05-14 1991-05-21 Cohen Allen L Multifocals using phase shifting
US5121979A (en) 1986-05-14 1992-06-16 Cohen Allen L Diffractive multifocal optical device
US5270744A (en) 1987-06-01 1993-12-14 Valdemar Portney Multifocal ophthalmic lens
US4828558A (en) 1987-07-28 1989-05-09 Kelman Charles D Laminate optic with interior Fresnel lens
US4981342A (en) 1987-09-24 1991-01-01 Allergan Inc. Multifocal birefringent lens system
US5054905A (en) 1987-11-12 1991-10-08 Cohen Allen L Progressive intensity phase bifocal
US5056908A (en) 1987-11-12 1991-10-15 Cohen Allen L Optic zone phase channels
US4881805A (en) 1987-11-12 1989-11-21 Cohen Allen L Progressive intensity phase bifocal
US5009497A (en) 1987-11-12 1991-04-23 Cohen Allen L Contact lenses utilizing keel orientation
CA1316728C (en) 1988-04-01 1993-04-27 Michael J. Simpson Multi-focal diffractive ophthalmic lenses
US5116111A (en) 1988-04-01 1992-05-26 Minnesota Mining And Manufacturing Company Multi-focal diffractive ophthalmic lenses
US5076684A (en) 1988-04-01 1991-12-31 Minnesota Mining And Manufacturing Company Multi-focal diffractive ophthalmic lenses
EP0681198A1 (en) 1988-07-20 1995-11-08 Allen L. Dr. Cohen Multifocal ophthalmic lens
US4995714A (en) 1988-08-26 1991-02-26 Cohen Allen L Multifocal optical device with novel phase zone plate and method for making
US5121980A (en) 1989-04-19 1992-06-16 Cohen Allen L Small aperture multifocal
US5002382A (en) 1989-12-07 1991-03-26 Leonard Seidner Multifocal corneal contact lenses
US5024517A (en) 1989-12-07 1991-06-18 Leonard Seidner Monovision corneal contact lenses
US4971432A (en) 1989-12-07 1990-11-20 Koeniger Erich A Bifocal contact lens
US5178636A (en) 1990-05-14 1993-01-12 Iolab Corporation Tuned fresnel lens for multifocal intraocular applications including small incision surgeries
US5096285A (en) 1990-05-14 1992-03-17 Iolab Corporation Multifocal multizone diffractive ophthalmic lenses
US5117306A (en) 1990-07-17 1992-05-26 Cohen Allen L Diffraction bifocal with adjusted chromaticity
US5229797A (en) 1990-08-08 1993-07-20 Minnesota Mining And Manufacturing Company Multifocal diffractive ophthalmic lenses
US5108169A (en) 1991-02-22 1992-04-28 Mandell Robert B Contact lens bifocal with switch
US5106180A (en) 1991-05-30 1992-04-21 Robert Marie Multifocal ophthalmic lens
SK377492A3 (en) 1992-01-28 1995-05-10 Johnson & Johnson Vision Prod Multifocal refracting lens and method of its manufacture
US5517259A (en) 1992-11-23 1996-05-14 Innotech, Inc. Method of manufacturing toric single vision, spherical or aspheric bifocal, multifocal or progressive contact lenses
US5406341A (en) 1992-11-23 1995-04-11 Innotech, Inc. Toric single vision, spherical or aspheric bifocal, multifocal or progressive contact lenses and method of manufacturing
US5448312A (en) 1992-12-09 1995-09-05 Johnson & Johnson Vision Products, Inc. Pupil-tuned multifocal ophthalmic lens
US5760871A (en) 1993-01-06 1998-06-02 Holo-Or Ltd. Diffractive multi-focal lens
US5349393A (en) 1993-06-01 1994-09-20 Kreft James P Light-transmitting elastomeric suction lens
CA2185685A1 (en) 1994-03-17 1995-09-21 Werner Fiala Zoned lens
DE59509463D1 (en) 1994-03-30 2001-09-06 Rodenstock Optik G PROGRESSIVE EYEGLASSES SERIES
HUP9601126A3 (en) 1995-05-04 1999-10-28 Johnson & Johnson Vision Prod Concentric, aspheric, multifocal lens
IL117935A0 (en) 1995-05-04 1996-08-04 Johnson & Johnson Vision Prod Multifocal ophthalmic lens
US5929969A (en) 1995-05-04 1999-07-27 Johnson & Johnson Vision Products, Inc. Multifocal ophthalmic lens
US6045578A (en) * 1995-11-28 2000-04-04 Queensland University Of Technology Optical treatment method
ATE367597T1 (en) 1996-04-04 2007-08-15 Carl Zeiss Vision Au Holding PROGRESSIVE LENSES AND METHODS OF DESIGN AND USE THEREOF
US5898473A (en) 1997-04-25 1999-04-27 Permeable Technologies, Inc. Multifocal corneal contact lens
US6626532B1 (en) * 1997-06-10 2003-09-30 Olympus Optical Co., Ltd. Vari-focal spectacles
US6343861B1 (en) 1998-06-12 2002-02-05 Sola International Holdings, Ltd. Myopia lens
IL124991A (en) 1998-06-18 2002-12-01 Rotlex 1994 Ltd Multifocal lens combining the advantages of progressive addition lenses and diffractive lenses
US6120148A (en) 1998-10-05 2000-09-19 Bifocon Optics Gmbh Diffractive lens
US20050099597A1 (en) * 2002-12-24 2005-05-12 Calhoun Vision Light adjustable multifocal lenses
US6491394B1 (en) * 1999-07-02 2002-12-10 E-Vision, Llc Method for refracting and dispensing electro-active spectacles
US6536899B1 (en) 1999-07-14 2003-03-25 Bifocon Optics Gmbh Multifocal lens exhibiting diffractive and refractive powers
US7803153B2 (en) * 1999-12-29 2010-09-28 New England College Of Optometry Method for preventing myopia progression through identification and correction of optical aberrations
FR2803921B1 (en) 2000-01-14 2002-04-05 Essilor Int SET OF TWO OPHTHALMIC LENSES, RANGE AND METHOD FOR CONSTITUTING SUCH A GAME
US6364483B1 (en) 2000-02-22 2002-04-02 Holo Or Ltd. Simultaneous multifocal contact lens and method of utilizing same for treating visual disorders
AU2001287997A1 (en) 2000-09-29 2002-04-08 Werner J. Fiala Ophthalmic lens with surface structures
CN1356785A (en) * 2000-12-07 2002-07-03 刘喜胜 Fresnel lens
SE0101293D0 (en) * 2001-04-11 2001-04-11 Pharmacia Groningen Bv Technical field of the invention
US6752499B2 (en) * 2001-07-11 2004-06-22 Thomas A. Aller Myopia progression control using bifocal contact lenses
US6559251B1 (en) 2002-08-02 2003-05-06 Equistar Chemicals, Lp Process for making low-density polyolefins
US7036931B2 (en) 2003-01-29 2006-05-02 Novartis Ag Ophthalmic lenses
US20040237971A1 (en) * 2003-06-02 2004-12-02 Hema Radhakrishnan Methods and apparatuses for controlling optical aberrations to alter modulation transfer functions
US6951391B2 (en) 2003-06-16 2005-10-04 Apollo Optical Systems Llc Bifocal multiorder diffractive lenses for vision correction
US7287852B2 (en) 2003-06-30 2007-10-30 Fiala Werner J Intra-ocular lens or contact lens exhibiting large depth of focus
ATE452611T1 (en) * 2003-11-19 2010-01-15 Vision Crc Ltd DEVICES FOR CHANGING THE RELATIVE CURRAVITY OF THE FIELD AND THE POSITIONS OF PERIPHERAL AXIS-SHIFTED FOCAL POSITIONS
US7503655B2 (en) 2003-11-19 2009-03-17 Vision Crc Limited Methods and apparatuses for altering relative curvature of field and positions of peripheral, off-axis focal positions
AU2005260234B2 (en) 2004-07-01 2010-12-09 Auckland Uniservices Limited Contact lens and method for prevention of myopia progression
US7697750B2 (en) 2004-12-06 2010-04-13 John Castle Simmons Specially coherent optics
US7401922B2 (en) 2005-04-13 2008-07-22 Synergeyes, Inc. Method and apparatus for reducing or eliminating the progression of myopia
US7073906B1 (en) 2005-05-12 2006-07-11 Valdemar Portney Aspherical diffractive ophthalmic lens
CA2637053C (en) 2006-01-12 2014-02-25 Institute For Eye Research Method and apparatus for controlling peripheral image position for reducing progression of myopia
CN101467092B (en) 2006-06-08 2011-01-12 视力Crc有限公司 Means for controlling the progression of myopia
CN101523270B (en) 2006-07-31 2010-12-08 眼科研究所 Corneal and epithelial remodelling
KR101535311B1 (en) 2007-03-09 2015-07-08 오클랜드 유니서비시즈 리미티드 Contact lens, method of correcting myopic vision, and method of producing a contact lens
WO2008131479A1 (en) 2007-04-27 2008-11-06 The Institute For Eye Research Limited Determination of optical adjustments for retarding myopia progression
US7637612B2 (en) 2007-05-21 2009-12-29 Johnson & Johnson Vision Care, Inc. Ophthalmic lenses for prevention of myopia progression
SG10201506615RA (en) 2008-04-18 2015-10-29 Holden Brien Vision Inst Myopia control means
WO2009152582A1 (en) 2008-06-17 2009-12-23 The Institute For Eye Research Limited Physical model eye systems and methods

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904281A (en) * 1969-12-08 1975-09-09 Optical Sciences Group Inc Flexible refracting membrane adhered to spectacle lens
US4210391A (en) * 1977-09-14 1980-07-01 Cohen Allen L Multifocal zone plate
WO1997010527A1 (en) * 1995-09-14 1997-03-20 The Regents Of The University Of California Structured index optics and ophthalmic lenses for vision correction
EP0927905A1 (en) * 1997-12-30 1999-07-07 Monique Mouflin Optical device for ambyopia
RU2197198C2 (en) * 2000-02-15 2003-01-27 Булатов Юрий Павлович All-purpose means for correcting pathological disorders of vision organs
RU2195233C1 (en) * 2001-05-23 2002-12-27 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Method for treating nystagmus and amblyopia

Cited By (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7766478B2 (en) 2004-07-01 2010-08-03 Auckland Uniservices Limited Contact lens and method for prevention of myopia progression
US7997725B2 (en) 2004-07-01 2011-08-16 Auckland Uniservices Limited Contact lens and method for prevention of myopia progression
EP2084568A2 (en) * 2006-10-10 2009-08-05 Novartis AG A lens having an optically controlled peripheral portion and a method for designing and manufacturing the lens
JP2010506240A (en) * 2006-10-10 2010-02-25 ノバルティス アーゲー Lens with optically controlled peripheral portion and method for designing and manufacturing the lens
EP2629138A3 (en) * 2006-10-10 2013-10-23 Novartis AG A contact lens for preventing myopia
US7832859B2 (en) 2007-03-09 2010-11-16 Auckland Uniservices Limited Contact lens and method
JP2010526563A (en) * 2007-04-27 2010-08-05 ザ インスティチュート フォー アイ リサーチ リミテッド Determination of visual acuity adjustment to delay the progression of myopia
DE102009053467A1 (en) 2008-11-14 2010-07-08 Rodenstock Gmbh Spectacles glass for e.g. preventing progression of myopia, has peripheral view regions with refractive power, which is partially changed from central view region in horizontal direction towards right and left edges of glass to same sign
AU2009330163B2 (en) * 2008-12-22 2014-05-01 The Medical College Of Wisconsin, Inc. Method and apparatus for limiting growth of eye length
US11493781B2 (en) 2008-12-22 2022-11-08 The Medical College Of Wisconsin, Inc. Method and apparatus for limiting growth of eye length
US10795181B2 (en) 2008-12-22 2020-10-06 The Medical College Of Wisconsin, Inc. Method and apparatus for limiting growth of eye length
US11048102B2 (en) 2008-12-22 2021-06-29 The Medical College Of Wisconsin, Inc. Method and apparatus for limiting growth of eye length
US8950860B2 (en) 2010-09-09 2015-02-10 The Hong Kong Polytechnic University Method and system for retarding the progression of myopia
US9829722B2 (en) 2010-09-09 2017-11-28 The Hong Kong Polytechnic University Method and system for retarding the progression of myopia
EP2616876B1 (en) 2010-09-13 2021-06-23 The Hong Kong Polytechnic University System for retarding progression of myopia
EP3929653A1 (en) 2010-09-13 2021-12-29 The Hong Kong Polytechnic University A method and system for retarding the progression of myopia
WO2014084411A1 (en) * 2012-11-30 2014-06-05 Essilor International Fresnel lens and optical device
US9709820B2 (en) 2012-11-30 2017-07-18 Essilor International (Compagnie Generale D'optique) Fresnel lens and optical device
US11927771B2 (en) 2014-06-05 2024-03-12 Optica Amuka (A.A.) Ltd. Control of dynamic lenses
US11543681B2 (en) 2016-08-01 2023-01-03 University Of Washington Ophthalmic lenses for treating myopia
US11718052B2 (en) 2017-05-08 2023-08-08 Sightglass Vision, Inc. Contact lenses for reducing myopia and methods for making the same
US11953764B2 (en) 2017-07-10 2024-04-09 Optica Amuka (A.A.) Ltd. Tunable lenses with enhanced performance features
US10884264B2 (en) 2018-01-30 2021-01-05 Sightglass Vision, Inc. Ophthalmic lenses with light scattering for treating myopia
US11914228B2 (en) 2018-01-30 2024-02-27 Sightglass Vision, Inc. Ophthalmic lenses with light scattering for treating myopia
US11353721B2 (en) 2018-03-01 2022-06-07 Essilor International Lens element
US11899286B2 (en) 2018-03-01 2024-02-13 Essilor International Lens element
US11852904B2 (en) 2018-03-01 2023-12-26 Essilor International Lens element
US11378818B2 (en) 2018-03-01 2022-07-05 Essilor International Lens element
US11385475B2 (en) 2018-03-01 2022-07-12 Essilor International Lens element
US11385476B2 (en) 2018-03-01 2022-07-12 Essilor International Lens element
US11442290B2 (en) 2018-03-01 2022-09-13 Essilor International Lens element
US11567344B2 (en) 2018-03-01 2023-01-31 Essilor International Lens element
US11958305B2 (en) 2019-10-23 2024-04-16 Carl Zeiss Vision International Gmbh Method of producing a spectacle lens and product comprising a spectacle lens
WO2021078989A1 (en) 2019-10-23 2021-04-29 Carl Zeiss Vision International Gmbh Method of producing a spectacle lens and product comprising a spectacle lens
EP3812142A1 (en) 2019-10-23 2021-04-28 Carl Zeiss Vision International GmbH Method for producing a spectacle lens and a product comprising a spectacle lens
WO2022038581A1 (en) * 2020-08-21 2022-02-24 Brien Holden Vision Institute Limited Ophthalmic devices, systems and/or methods for management of ocular conditions and/or reducing night vision disturbances
WO2022084557A1 (en) 2020-10-23 2022-04-28 Carl Zeiss Vision International Gmbh Method of manufacturing a spectacle lens
WO2022084558A1 (en) 2020-10-23 2022-04-28 Carl Zeiss Vision International Gmbh Method for manufacturing a spectacle lens
EP3988290A1 (en) 2020-10-23 2022-04-27 Carl Zeiss Vision International GmbH Method for manufacturing a spectacle lens
EP3988288A1 (en) 2020-10-23 2022-04-27 Carl Zeiss Vision International GmbH Method of manufacturing a spectacle lens
EP3988289A1 (en) 2020-10-23 2022-04-27 Carl Zeiss Vision International GmbH Method of manufacturing a spectacle lens
US11926557B2 (en) 2020-10-23 2024-03-12 Carl Zeiss Vision International Gmbh Method of manufacturing a spectacle lens
WO2022084559A2 (en) 2020-10-23 2022-04-28 Carl Zeiss Vision International Gmbh Method of manufacturing a spectacle lens
US11899287B2 (en) 2020-10-23 2024-02-13 Carl Zeiss Vision International Gmbh Method of manufacturing a spectacle lens
EP4270098A2 (en) 2020-11-26 2023-11-01 Carl Zeiss Vision International GmbH Spectacle lens design, spectacle lens kit, data set, computer-implemented method of designing a spectacle lens and method of manufacturing a spectacle lens
EP4006626A1 (en) 2020-11-26 2022-06-01 Carl Zeiss Vision International GmbH Spectacle lens design, spectacle lens kit and method of manufacturing a spectacle lens
WO2022112533A2 (en) 2020-11-26 2022-06-02 Carl Zeiss Vision International Gmbh Spectacle lens design, spectacle lens kit, data set, computer-implemented method of designing a spectacle lens and method of manufacturing a spectacle lens
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