WO2006032909A3 - Pka ii anchoring disruption polypeptide - Google Patents

Pka ii anchoring disruption polypeptide Download PDF

Info

Publication number
WO2006032909A3
WO2006032909A3 PCT/GB2005/003677 GB2005003677W WO2006032909A3 WO 2006032909 A3 WO2006032909 A3 WO 2006032909A3 GB 2005003677 W GB2005003677 W GB 2005003677W WO 2006032909 A3 WO2006032909 A3 WO 2006032909A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecule
pka
polypeptide
anchoring disruption
mimic
Prior art date
Application number
PCT/GB2005/003677
Other languages
French (fr)
Other versions
WO2006032909A2 (en
Inventor
Birgitte Lygren
Cathrine Rein Carlson
Kjetil Tasken
John Scott
Original Assignee
Univ Oslo
Jones Elizabeth Louise
Birgitte Lygren
Cathrine Rein Carlson
Kjetil Tasken
John Scott
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oslo, Jones Elizabeth Louise, Birgitte Lygren, Cathrine Rein Carlson, Kjetil Tasken, John Scott filed Critical Univ Oslo
Publication of WO2006032909A2 publication Critical patent/WO2006032909A2/en
Publication of WO2006032909A3 publication Critical patent/WO2006032909A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A PKA II anchoring disruption molecule or AKAP mimic, wherein said molecule or mimic is a polypeptide which comprises the following amino acid sequence: X1 X2 E X3 X4 A K Q I V X5 X6 X7 I X8 X9 X10 (sequence (1) ) or a peptidomimetic or analogue thereof is provided. Also provided are antibodies to the molecule, nucleic acid molecules comprising a sequence encoding the molecule and pharmaceutical compositions. A method of altering the PKA type II signalling pathway in a cell by administration of the anchoring disruption molecule or AKAP mimic, in particular to treat cardiovascular and metabolic disorders is also provided.
PCT/GB2005/003677 2004-09-24 2005-09-26 Pka ii anchoring disruption polypeptide WO2006032909A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0421356.7 2004-09-24
GB0421356A GB0421356D0 (en) 2004-09-24 2004-09-24 Inhibitors

Publications (2)

Publication Number Publication Date
WO2006032909A2 WO2006032909A2 (en) 2006-03-30
WO2006032909A3 true WO2006032909A3 (en) 2006-11-02

Family

ID=33397258

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/003677 WO2006032909A2 (en) 2004-09-24 2005-09-26 Pka ii anchoring disruption polypeptide

Country Status (2)

Country Link
GB (1) GB0421356D0 (en)
WO (1) WO2006032909A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0518027D0 (en) * 2005-09-05 2005-10-12 Birkeland Innovasjon As Compounds
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
ES2672974T3 (en) * 2012-06-01 2018-06-19 Ibc Pharmaceuticals, Inc. Multimeric complexes with improved in vivo stability, improved pharmacokinetics and efficacy
WO2015010048A1 (en) * 2013-07-19 2015-01-22 University Of Georgia Research Foundation, Inc. Chemically-stabilized a kinase anchoring protein (akap) peptide disruptors
GB201320506D0 (en) 2013-11-26 2014-01-01 Uni I Oslo Cyclic amino compounds for the use in the treatment of cardiac disorders

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALTO NEAL M ET AL: "Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 8, 15 April 2003 (2003-04-15), pages 4445 - 4450, XP002375233, ISSN: 0027-8424 *
BURNS-HAMURO LORA L ET AL: "Designing isoform-specific peptide disruptors of protein kinase A localization.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1 APR 2003, vol. 100, no. 7, 1 April 2003 (2003-04-01), pages 4072 - 4077, XP002369142, ISSN: 0027-8424 *
HAUSKEN ZACHARY E ET AL: "Mutational analysis of the A-kinase anchoring protein (AKAP)-binding site on RII: Classification of side chain determinants for anchoring and isoform selective association worth", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 46, 1996, pages 29016 - 29022, XP002375234, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
GB0421356D0 (en) 2004-10-27
WO2006032909A2 (en) 2006-03-30

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