WO2006032054A3 - Differenciation de cellules souches mesenchateuses de cellules souches cardiaques qui favorisent la cure cardiaque - Google Patents

Differenciation de cellules souches mesenchateuses de cellules souches cardiaques qui favorisent la cure cardiaque Download PDF

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Publication number
WO2006032054A3
WO2006032054A3 PCT/US2005/033422 US2005033422W WO2006032054A3 WO 2006032054 A3 WO2006032054 A3 WO 2006032054A3 US 2005033422 W US2005033422 W US 2005033422W WO 2006032054 A3 WO2006032054 A3 WO 2006032054A3
Authority
WO
WIPO (PCT)
Prior art keywords
cardiac
differentiation
mesenchymal stem
human mesenchymal
stem cells
Prior art date
Application number
PCT/US2005/033422
Other languages
English (en)
Other versions
WO2006032054A2 (fr
WO2006032054A9 (fr
Inventor
Ira S Cohen
Michael R Rosen
Richard B Robinson
Peter R Brink
Glenn Gaudette
Irina Potapova
Original Assignee
Univ Columbia
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Univ New York State Res Found filed Critical Univ Columbia
Priority to EP05812162A priority Critical patent/EP1805300A4/fr
Publication of WO2006032054A2 publication Critical patent/WO2006032054A2/fr
Publication of WO2006032054A9 publication Critical patent/WO2006032054A9/fr
Publication of WO2006032054A3 publication Critical patent/WO2006032054A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C12N2533/92—Amnion; Decellularised dermis or mucosa

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé permettant de traiter, in vivo, un patient souffrant d'un trouble cardiaque. Ce procédé consiste (i) à induire la différenciation d'une cellule souche, in vitro, d'une cellule cardiogène; et (ii) à administrer une quantité thérapeutiquement efficace de la cellule cardiogène de l'étape (i) au patient, ce qui permet de traiter le trouble cardiaque du patient. L'invention concerne également des articles de production et des procédés.
PCT/US2005/033422 2004-09-14 2005-09-14 Differenciation de cellules souches mesenchateuses de cellules souches cardiaques qui favorisent la cure cardiaque WO2006032054A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05812162A EP1805300A4 (fr) 2004-09-14 2005-09-14 Différenciation de cellules souches mésenchateuses de cellules souches cardiaques qui favorisent la cure cardiaque

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94103404A 2004-09-14 2004-09-14
US10/941,034 2004-09-14

Publications (3)

Publication Number Publication Date
WO2006032054A2 WO2006032054A2 (fr) 2006-03-23
WO2006032054A9 WO2006032054A9 (fr) 2006-05-26
WO2006032054A3 true WO2006032054A3 (fr) 2009-04-16

Family

ID=36060741

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/033422 WO2006032054A2 (fr) 2004-09-14 2005-09-14 Differenciation de cellules souches mesenchateuses de cellules souches cardiaques qui favorisent la cure cardiaque

Country Status (2)

Country Link
EP (1) EP1805300A4 (fr)
WO (1) WO2006032054A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2269461B1 (fr) 2004-07-30 2017-03-22 Mayo Foundation For Medical Education And Research Traitement de tissu cardiovasculaire
US8431397B2 (en) 2004-09-14 2013-04-30 The Trustees Of Columbia University In The City Of New York Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair
US8592209B2 (en) 2006-01-30 2013-11-26 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
US9765298B2 (en) 2006-07-24 2017-09-19 Mayo Foundation For Medical Education And Research Methods and materials for providing cardiac cells
JP2010505849A (ja) 2006-10-06 2010-02-25 ユニバーシティ オブ バージニア パテント ファウンデーション 糖尿病性創傷治癒に有用な方法および組成物
US20100189697A1 (en) * 2007-03-07 2010-07-29 Andre Terzic Cardiac-specific progenitor cells
WO2009145761A1 (fr) 2008-05-27 2009-12-03 Mayo Foundation For Medical Education And Research Procédés et matériaux destinés à utiliser des cellules dans le traitement du tissu cardiaque
US11147673B2 (en) 2018-05-22 2021-10-19 Boston Scientific Scimed, Inc. Percutaneous papillary muscle relocation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007993A (en) * 1995-06-28 1999-12-28 Insitut Fur Pflanzengenetik Und Kulturpflanzenforschung In vitro test for embryotoxic and teratogenic agents using differentiation-dependent reporter expression in pluripotent rodent embryonic cells
US20020022259A1 (en) * 2000-01-14 2002-02-21 Lee Ike W. Cardiac-cell specific enhancer elements and uses thereof
US20020076400A1 (en) * 1999-03-10 2002-06-20 University Of Pittsburgh Of The Commonwealth System Of Higher Education Adipose-derived stem cells and lattices

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006029084A2 (fr) * 2004-09-03 2006-03-16 Cornell Research Foundation, Inc. Cellules souches oct3/4+ derivees de la moelle osseuse

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007993A (en) * 1995-06-28 1999-12-28 Insitut Fur Pflanzengenetik Und Kulturpflanzenforschung In vitro test for embryotoxic and teratogenic agents using differentiation-dependent reporter expression in pluripotent rodent embryonic cells
US20020076400A1 (en) * 1999-03-10 2002-06-20 University Of Pittsburgh Of The Commonwealth System Of Higher Education Adipose-derived stem cells and lattices
US20020022259A1 (en) * 2000-01-14 2002-02-21 Lee Ike W. Cardiac-cell specific enhancer elements and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1805300A4 *

Also Published As

Publication number Publication date
WO2006032054A2 (fr) 2006-03-23
EP1805300A4 (fr) 2009-09-09
WO2006032054A9 (fr) 2006-05-26
EP1805300A2 (fr) 2007-07-11

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