WO2006027116A3 - Formulierungen des peptids p277 oder dessen varianten mit optimierter stabilität - Google Patents

Formulierungen des peptids p277 oder dessen varianten mit optimierter stabilität Download PDF

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Publication number
WO2006027116A3
WO2006027116A3 PCT/EP2005/009223 EP2005009223W WO2006027116A3 WO 2006027116 A3 WO2006027116 A3 WO 2006027116A3 EP 2005009223 W EP2005009223 W EP 2005009223W WO 2006027116 A3 WO2006027116 A3 WO 2006027116A3
Authority
WO
WIPO (PCT)
Prior art keywords
variants
peptide
peptide formulations
optimised
stability
Prior art date
Application number
PCT/EP2005/009223
Other languages
English (en)
French (fr)
Other versions
WO2006027116A2 (de
Inventor
Caroline Hops
Werner Mueller
Original Assignee
Sanofi Aventis Deutschland
Caroline Hops
Werner Mueller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland, Caroline Hops, Werner Mueller filed Critical Sanofi Aventis Deutschland
Priority to EP05782956A priority Critical patent/EP1791529A2/de
Publication of WO2006027116A2 publication Critical patent/WO2006027116A2/de
Publication of WO2006027116A3 publication Critical patent/WO2006027116A3/de
Priority to IL181557A priority patent/IL181557A0/en
Priority to US11/678,792 priority patent/US20070299245A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Formulierung des Peptids p277 oder dessen Varianten mit optimierter Stabilität Die Erfindung betrifft Formulierungen enthaltend das Peptid p277 sowie dessen Varianten, die sich durch eine erhöhte Stabilität während der Lagerung und des Transports auszeichnen. Die Erfindung betrifft daher Formulierungen enthaltend das Peptid p277 oder dessen Varianten und einen Citratpuffer.
PCT/EP2005/009223 2004-09-10 2005-08-26 Formulierungen des peptids p277 oder dessen varianten mit optimierter stabilität WO2006027116A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05782956A EP1791529A2 (de) 2004-09-10 2005-08-26 Formulierungen des peptids p277 oder dessen varianten mit optimierter stabilität
IL181557A IL181557A0 (en) 2004-09-10 2007-02-26 p277 PEPTIDE FORMULATIONS OR VARIANTS THEREOF HAVING OPTIMIZED STABILITY
US11/678,792 US20070299245A1 (en) 2004-09-10 2007-02-26 P277 peptide formulations or variants thereof having optimized stability

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004043750A DE102004043750A1 (de) 2004-09-10 2004-09-10 Formulierungen des Peptids p277 oder dessen Varianten mit optimierter Stabilität
DE102004043750.5 2004-09-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/678,792 Continuation US20070299245A1 (en) 2004-09-10 2007-02-26 P277 peptide formulations or variants thereof having optimized stability

Publications (2)

Publication Number Publication Date
WO2006027116A2 WO2006027116A2 (de) 2006-03-16
WO2006027116A3 true WO2006027116A3 (de) 2007-01-25

Family

ID=35636906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/009223 WO2006027116A2 (de) 2004-09-10 2005-08-26 Formulierungen des peptids p277 oder dessen varianten mit optimierter stabilität

Country Status (5)

Country Link
US (1) US20070299245A1 (de)
EP (1) EP1791529A2 (de)
DE (1) DE102004043750A1 (de)
IL (1) IL181557A0 (de)
WO (1) WO2006027116A2 (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019236A1 (en) * 1994-12-21 1996-06-27 Yeda Research And Development Co. Ltd. PEPTIDE p277 ANALOGS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR TREATMENT OR DIAGNOSIS OF DIABETES
WO2004064788A2 (en) * 2003-01-14 2004-08-05 Teva Pharmaceutical Industries, Ltd. Parenteral formulations of a peptide for the treatment of systemic lupus erythematosus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2612599A (en) * 1998-03-13 1999-10-11 Novo Nordisk A/S Stabilized aqueous peptide solutions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019236A1 (en) * 1994-12-21 1996-06-27 Yeda Research And Development Co. Ltd. PEPTIDE p277 ANALOGS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR TREATMENT OR DIAGNOSIS OF DIABETES
EP0820303A1 (de) * 1994-12-21 1998-01-28 Yeda Research & Development Company, Ltd. p277 PEPTIDANALOGE, PHARMAZEUTISCHE ZUSAMMENSTELLUNG DAVON ZUR BEHANDLUNG UND DIAGNOSE VON DIABETES
WO2004064788A2 (en) * 2003-01-14 2004-08-05 Teva Pharmaceutical Industries, Ltd. Parenteral formulations of a peptide for the treatment of systemic lupus erythematosus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ELIAS D ET AL: "TREATMENT OF AUTOIMMUNE DIANETES AND INSULITIS IN NOD MICE WITH HEAT SHOCK PROTEIN 60 PEPTIDE P277", DIABETES, NEW YORK, NY, US, vol. 44, no. 9, September 1995 (1995-09-01), pages 1132 - 1138, XP001034245, ISSN: 0012-1797 *

Also Published As

Publication number Publication date
DE102004043750A1 (de) 2006-03-30
EP1791529A2 (de) 2007-06-06
IL181557A0 (en) 2007-07-04
WO2006027116A2 (de) 2006-03-16
US20070299245A1 (en) 2007-12-27

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