WO2006023757A3 - Novel tricyclic, bicyclic, monocyclic, and acyclic amines as potent sodium channel blocking agents - Google Patents

Novel tricyclic, bicyclic, monocyclic, and acyclic amines as potent sodium channel blocking agents Download PDF

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Publication number
WO2006023757A3
WO2006023757A3 PCT/US2005/029605 US2005029605W WO2006023757A3 WO 2006023757 A3 WO2006023757 A3 WO 2006023757A3 US 2005029605 W US2005029605 W US 2005029605W WO 2006023757 A3 WO2006023757 A3 WO 2006023757A3
Authority
WO
WIPO (PCT)
Prior art keywords
sodium channel
bicyclic
monocyclic
blocking agents
channel blocking
Prior art date
Application number
PCT/US2005/029605
Other languages
French (fr)
Other versions
WO2006023757A2 (en
Inventor
Milton L Brown
Original Assignee
Univ Virginia
Milton L Brown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia, Milton L Brown filed Critical Univ Virginia
Publication of WO2006023757A2 publication Critical patent/WO2006023757A2/en
Publication of WO2006023757A3 publication Critical patent/WO2006023757A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/31—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by at least three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Abstract

The present invention provides acyclic, bicyclic, monocyclic, and tricyclic analogs and derivatives of tricyclic antidepressants which have sodium channel inhibiting activity. The compounds of the invention are useful as analgesics and anesthetics for diseases, conditions, and disorders where regulation of sodium channel activity can alleviate pain.
PCT/US2005/029605 2004-08-19 2005-08-19 Novel tricyclic, bicyclic, monocyclic, and acyclic amines as potent sodium channel blocking agents WO2006023757A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60281904P 2004-08-19 2004-08-19
US60/602,819 2004-08-19

Publications (2)

Publication Number Publication Date
WO2006023757A2 WO2006023757A2 (en) 2006-03-02
WO2006023757A3 true WO2006023757A3 (en) 2006-08-03

Family

ID=35968223

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029605 WO2006023757A2 (en) 2004-08-19 2005-08-19 Novel tricyclic, bicyclic, monocyclic, and acyclic amines as potent sodium channel blocking agents

Country Status (1)

Country Link
WO (1) WO2006023757A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
WO2008121859A1 (en) * 2007-03-30 2008-10-09 Xenon Pharmaceuticals Inc. Methods of using tricyclic compounds in treating sodium channel-mediated diseases or conditions
US8629135B2 (en) 2008-07-14 2014-01-14 Queen's University At Kingston Pharmaceutical compositions comprising RET inhibitors and methods for the treatment of cancer
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
AR080055A1 (en) 2010-02-01 2012-03-07 Novartis Ag DERIVATIVES OF PIRAZOLO- [5,1-B] -OXAZOL AS ANTAGONISTS OF THE RECEIVERS OF CRF -1
JP5748777B2 (en) 2010-02-02 2015-07-15 ノバルティス アーゲー Cyclohexylamide derivatives as CRF receptor antagonists
US8546416B2 (en) 2011-05-27 2013-10-01 Novartis Ag 3-spirocyclic piperidine derivatives as ghrelin receptor agonists
AU2013255458A1 (en) 2012-05-03 2014-10-09 Novartis Ag L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022895A (en) * 1997-03-14 2000-02-08 Gruenenthal Gmbh Substituted amino compounds and their use as substances having an analgesic effect
US6262104B1 (en) * 1995-09-15 2001-07-17 Smithkline Beecham P.L.C. Diarylalkenylamine derivatives
US6545057B2 (en) * 2000-09-26 2003-04-08 The Brigham And Women's Hospital Inc. Tricyclic antidepressants and their analogues as long-acting local anesthetics and analgesics
US20030096805A1 (en) * 2000-09-26 2003-05-22 Wang Ging Kuo Antidepressants and their analogues as long-acting local anesthetics and analgesics

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262104B1 (en) * 1995-09-15 2001-07-17 Smithkline Beecham P.L.C. Diarylalkenylamine derivatives
US6022895A (en) * 1997-03-14 2000-02-08 Gruenenthal Gmbh Substituted amino compounds and their use as substances having an analgesic effect
US6545057B2 (en) * 2000-09-26 2003-04-08 The Brigham And Women's Hospital Inc. Tricyclic antidepressants and their analogues as long-acting local anesthetics and analgesics
US20030096805A1 (en) * 2000-09-26 2003-05-22 Wang Ging Kuo Antidepressants and their analogues as long-acting local anesthetics and analgesics

Also Published As

Publication number Publication date
WO2006023757A2 (en) 2006-03-02

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