WO2006022718A1 - Akt3 compositions and methods of use - Google Patents

Akt3 compositions and methods of use Download PDF

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WO2006022718A1
WO2006022718A1 PCT/US2004/026569 US2004026569W WO2006022718A1 WO 2006022718 A1 WO2006022718 A1 WO 2006022718A1 US 2004026569 W US2004026569 W US 2004026569W WO 2006022718 A1 WO2006022718 A1 WO 2006022718A1
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PCT/US2004/026569
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Dirksen Bussiere
Eric Fang
Jeremy Murray
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Novartis Vaccines And Diagnostics Inc.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Definitions

  • the present invention relates to the compositions, crystals, and the three dimensional structures of Akt3 and its mutants, to methods for forming the crystals, and to methods for using the three dimensional structures to design and identify therapeutic compounds for the treatment of Akt3 mediated diseases.
  • Humphreys, S.; Alessi, D.R. (2003) WNKl, the kinase mutated in an inherited high blood pressure syndrome, is a novel PKB/ Akt substrate.
  • vAkt was first identified as a cell-derived, viral oncogene present in the transforming murine leukemia retrovirus, AKT8 (Staal and Hartley, 1988). The virus was unusual in its ability to transform mink lung epithelial cells but not other cells, such as NIH3T3 fibroblasts, suggesting the presence of a novel, cell-type specific oncogene.
  • PKT Protein kinase B
  • AGC protein kinase superfamily was identified as the cellular homologue of Akt, giving rise to the current "PKB/Akt" nomenclature system (Brazil and Hemmings, 2001 ; and references within).
  • Aktl/ PKB ⁇ Akt2/ PKB ⁇
  • Akt3/ PKB ⁇ Akt3/ PKB ⁇
  • PKB/Akt was later shown to mediate downstream events associated with phosphatidylinositol 3-kinase (PI3K), which is recruited to the plasma membrane in response to growth factors (including platelet-derived growth factor (PDGF), epidermal growth factor (EGF) 5 basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF-I), nerve growth factor (NGF), stem cell factor, and vascular endothelial growth factor), cytokines (including interleukins 2, 3, 4, 5, and 8), insulin, bradykinin, RANTES, and endothelin, as well as attachment to the extracellular matrix (ECM) and various forms of cell stress (e.g., hypoxia and heat shock) (Lawlor and Alessi, 2001; Brazil and Hemmings, 2001; Scheid and Woodgett, 2003).
  • PDGF platelet-derived growth factor
  • EGF epidermal growth factor
  • bFGF basic fibroblast growth factor
  • IGF-I insulin-like growth factor
  • PI3K converts phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P 2 ; PIP2) to the lipid second-messenger, phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P 3 ; PIP3).
  • PIP3 or its breakdown product, phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P 3 ; PI(3,4)P2), recruits PKB/ Akt to the plasma membrane via the N-terminal, pleckstrin homology (PH) region of PKB.
  • HM docking domain
  • PDKl 3-phosphoinoside-dependent kinase
  • AGC AGC family kinase
  • Membrane bound PKB is activated by multi-site phosphorylation, particularly within the activation T-loop of the central catalytic domain. Phosphorylation at a threonine residue (Thr308 of PKB ⁇ , Thr309 of PKB ⁇ , Thr305 of PKB ⁇ ), situated within the activation T-loop, appears to be performed by PDKl, and is necessary for PKB activity.
  • Phosphorylation at a serine residue (Ser473 of PKB ⁇ , Ser474 of PKB ⁇ , Ser472 of PKB ⁇ ), located at the C-terminal hydrophobic domain of PKB, is also important for maximum PKB activity, although the mechanism of phosphorylation is not clear (Brazil and Hemmings, 2001; Scheid and Woodgett, 2003).
  • Phosphorylated PKB then participates in a number of downstream signaling events related to cell cycle regulation, survival, motility and growth (Lawlor and Alessi, 2001; Scheid and Woodgett, 2003). These processes are essential for normal cell function. In addition, mutations and/or aberrant expression of polypeptides affecting the activity and/or production of phosphorylated PKB have been implicated in human cancer (Luo et ah, 2003).
  • Aktl has been found to be overexpressed in gastric adenocarcinomas.
  • Akt2 overexpression is found in breast, ovarian, and pancreatic cancers.
  • Akt3 has recently been found to be overexpressed in estrogen negative breast cancers and androgen- insensitive prostate carcinomas (Nakatani et. al, 1999).
  • Akt3 is expressed in a limited number of tissues. Such preferential expression has generated interest in Akt3 as an attractive target for small molecule inhibition (Walker, et. al. 1998).
  • Akt3 shows approximately an 83% protein sequence identity to Aktl and a 78% identity to Akt2 (Masure et. al., 1999).
  • a crystal structure of Akt2/PKB ⁇ containing amino acid residues 143-481 has been determined (Huang, X. et. al. 2003). In this protein, Thr309 and Ser474 were unphosphorylated, which was found to reduce its activity.
  • Other truncated Akt2/PKB ⁇ crystal structures are also known.
  • WO 03/016516 discloses Akt2 crystals having residues 146-460, with Thr309 either phosphorylated or unphosphorylated, as well as crystals having residues 146-481.
  • the present invention provides various Akt3 compositions such as Akt3 polypeptides and crystals, and methods for producing Akt3 crystals.
  • the invention further provides methods for using the atomic coordinates corresponding to the crystal structures of Akt3 and its complexes to design and identify therapeutic compounds for the treatment of Akt3 mediated diseases.
  • the invention provides an Akt3 polypeptide crystal that is resolvable using X-ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination of the Akt3 polypeptide.
  • the Akt3 polypeptide has at least a 90% amino acid sequence identity to residues 138 to 479 of SEQ ID NO:1 or SEQ ID NO:2.
  • the sequence identity is at least 95%.
  • at least one of the Akt3 amino acid residues 305 or 472 is an aspartic amino acid.
  • the invention provides an Akt3 crystal, having the atomic coordinates set forth in Table 1, of an Akt3 polypeptide corresponding to SEQ ID NO:1.
  • the invention provides an Akt3 crystal, having the atomic coordinates set forth in Table 2, of an Akt3 mutant polypeptide having T305D and S472D substitutions corresponding to SEQ ID NO:2.
  • the invention provides a co-crystal of an Akt3 polypeptide complexed to an Akt3 binding compound wherein the co-crystal is resolvable using X-ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination of the Akt3 complex.
  • the invention provides an Akt3 co-crystal having the atomic coordinates set forth in Table 3, of an Akt3 polypeptide complexed to N-[6-(aminomethyl)-4-chloro-l,3- benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide.
  • the invention provides an Akt3 co-crystal having the atomic coordinates set forth in Table 4, of an Akt3 polypeptide complexed to N-[(lS)-2- amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thio ⁇ hene-2- carboxamide.
  • the invention provides an Akt3 co-crystal having the atomic coordinates set forth in Table 5, of an Akt3 mutant polypeptide having T305D and S472D substitutions and complexed to N-[(lS)-2-amino-l-(2,4- dichlorobenzyl)ethyl]-5-[2-(methylamino)pyriniidin-4-yl]thiophene-2-carboxamide.
  • the present invention further provides a method for crystallizing an Akt3 polypeptide complexed to a compound, comprising: (a) providing an Akt3 polypeptide; (b) contacting the Akt3 polypeptide with a compound; and (c) crystallizing the Akt3 polypeptide and compound from a solution to provide a crystallized complex, wherein the crystallized complex is resolvable using X-ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination.
  • the Akt3 polypeptide comprises amino acid residues 138-479 of SEQ ID NO:1. In other embodiments, the Akt3 polypeptide comprises amino acid residues 138-479 of SEQ ID NO:2. hi yet another embodiment the Akt3 polypeptide provided is an Akt3 polypeptide crystal.
  • the present invention provides a method for evaluating the ability of a compound to associate with an Akt3 polypeptide, the method comprising the steps of: (a) providing a three dimensional Akt3 structure using at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5, wherein the atomic coordinate root mean square deviation is less than 3. ⁇ A; (b) providing a three dimensional compound structure of said compound; (c) employing a fitting process to dock or superimpose said three dimensional compound structure onto said three dimensional Akt3 structure; and (d) analyzing the results of said fitting process.
  • the present invention provides a method for identifying a compound capable of modifying Akt3 activity, the method comprising the steps of: (a) providing a three dimensional Akt3 structure using at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5, wherein the atomic coordinate root mean square deviation is less than 3. ⁇ A; (b) providing a three dimensional compound structure of said compound; (c) employing a fitting process to dock or superimpose said three dimensional compound structure onto said three dimensional Akt3 structure; (d) analyzing the results of said fitting process; (e) synthesizing the compound; and (f) contacting the compound with an Akt3 polypeptide to determine the ability of the compound to modify Akt3 activity.
  • the root mean square deviation of the atomic coordinates in Tables 1, 2, 3, 4, or 5, is less than 2.5A. In other embodiments, the root mean square deviation is less than 2.0A. In yet other embodiments the root mean square deviation is less than 1. ⁇ A. In still other embodiments the root mean square deviation is less than 0.5A. In yet other embodiments the root mean square deviation is less than 0.1 A.
  • the three dimensional Akt3 structure has at least the amino acids set forth in Tables 6, 7, 8, 9, 10, or 11.
  • the three dimensional compound structure associates with one or more amino acid set forth in Tables 6, 7, 8, 9, 10, or 11.
  • the three dimensional compound structure is a known kinase inhibitor or portion thereof.
  • the three dimensional compound structure or portion thereof is N-[(lS)-2-amino-l- (2,4-dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2- carboxamide or N-[6-(aminomethyl)-4-chloro-l ,3-benzothiazol-2-yl]-5-(2- aminopyrimidin-4-yl)thiophene-2-carboxamide.
  • the three dimensional compound structure is selected from a database, hi a further embodiment, the three dimensional compound structure is designed de novo. hi some embodiments, the compound is a competitive ATP inhibitor.
  • the present invention also provides a computer for producing a three- dimensional representation of a molecule or molecular complex, wherein the computer comprises: (a) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5; (b) a working memory for storing instructions for processing said machine-readable data; (c) a central-processing unit coupled to said working memory and to said machine- readable data storage medium for processing said machine readable data into said three-dimensional representation; and (d) a means for displaying said three- dimensional representation.
  • the present invention further provides a computer for determining at least a portion of the atomic coordinates corresponding to an X-ray diffraction pattern of a molecule or molecular complex, wherein said computer comprises: (a) a machine- readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5; (b) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises an X-ray diffraction pattern of said molecule or molecular complex; (c) a working memory for storing instructions for processing said machine-readable data of (a) and (b); (d) a central-processing unit coupled to said working memory and to said machine-readable data storage medium of (a) and (b) for performing a Fourier transform of the machine readable data of (a) and for processing said machine readable data of (b) into structure coordinates; and
  • Figure 1 shows the crystal structure of Akt3 (2.5 Angstroms) corresponding to the atomic coordinates in Table 1.
  • Figure 2 shows the crystal structure of the Akt3 (T305D and S472D) mutant (1.95 Angstroms) corresponding to the atomic coordinates in Table 2.
  • Figure 3 shows the crystal structure of Akt3 complexed to N- [6- (aminomethyl)-4-chloro-l,3-benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene- 2-carboxamide (2.4 Angstroms) corresponding to the atomic coordinates in Table 3.
  • Figure 4 shows the crystal structure of Akt3 complexed to N-[(l S)-2- amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2- carboxamide (2.5 Angstroms) corresponding to the atomic coordinates in Table 4.
  • Figure 5 shows the crystal structure of the Akt3 (T305D and S472D) mutant complexed to N-[(lS)-2-amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2- (methylamino)pyrirnidin-4-yl]thiophene-2-carboxamide (2.35 Angstroms) corresponding to the atomic coordinates in Table 5.
  • Akt3 polypeptide refers to the native protein, mutants, variants, and portions thereof.
  • Akt3 mutants include proteins arising from replacement of one or more amino acid residues in the native protein with different amino acid residues.
  • Akt3 variants also include chimeric or fusion proteins.
  • Akt3 binding compound refers to compounds capable of binding to Akt3 and altering its activity. Akt3 binding compounds include compounds disclosed in WO 2004/007498, WO 2004/007499, WO 03/076429, WO 03/064397, WO 03/091246, WO 02/22610, WO 01/56993, WO 01/57022, WO 02/50065, WO 03/051366, WO 04/016597, and US provisional application 60/558342 filed March 30, 2004. The disclosures of these applications are incorporated by reference and for all purposes as if fully set forth therein.
  • SEQ ID NO: 1 refers to the expressed Akt3 polypeptide.
  • ID NO: 2 refers to the double mutant (T305D and S472D) Akt3 polypeptide, wherein the respective threonine and serine amino acid residues are replaced with aspartic acid residues. Both polypeptide sequences start with the N-terminal initiation Met (M) followed by Ala (A) which was included for ease of cloning. Next is the 6x His (H) purification tag. After the tag comes the Tev processing site, Glu-Asn-Leu-Tyr-Phe- Gln-Gly (ENLYFQG).
  • polypeptide residues are numbered Tl 38 to E479 in accordance with the numbering convention used in the Akt3 GenBank accession number NP_005456 (amino acid residues 1-479 of NP_005456 is shown in SEQ ID NO:3).
  • N,N'-Carbonyldiimidazole (1.0 eq) was added to a 0.2 M solution of compound 1C in anhydrous tetrahydrofuran. The mixture was stirred for 3 h at 50 0 C. The solution was returned to ambient temperature, and l-azidomethyl-2-(2,4- dichlorophenyl)ethylamine 2 (1.1 eq; see Scheme 2 below for synthesis) was added. The solution was stirred an additional 15 h at 50 0 C. The reaction mixture was diluted with one volume of methanol, and 3 M aqueous hydrochloric acid was then added (30 eq). The reaction was stirred 3 h at 50 0 C.
  • a reaction vessel containing a 0.05 M solution of compound ID was purged with argon.
  • a catalytic amount of 10% wt palladium on carbon was added.
  • the reaction vessel was purged with hydrogen, and the reaction was stirred at ambient temperature for 3 h.
  • the palladium was removed by filtration, and the filtrate was concentrated under reduced pressure.
  • the crude material was purified by reverse- phase HPLC to give compound 1.
  • ES/MS m/z 436 (MH + ), C 19 H 19 Cl 2 N 5 OS 436 g/mol.
  • Step 4 Deprotection to free amine: l-azidomethyl-2-(2,4-dichlorophenyl)ethylamine (2)
  • Step 3 Condensation to amide (3)
  • N,N'-Carbonyldiimidazole (1.00 eq) was added to a 0.2 M solution of compound 3C in anhydrous 1,4-dioxane. The mixture was stirred for 3 h at 6O 0 C. The solution was returned to ambient temperature, and 2-amino-6-(N-Boc- amino)methyl-4-chlorobenzthiazole 4 (1.1 eq, see Scheme 4 for synthesis) was added. The solution was stirred an additional 42 h at 100 °C. The reaction mixture was diluted with one volume of methanol, and 3 M aqueous hydrochloric acid was added (30 eq).
  • Step 5 Conversion to N-Boc-aminomethylbenzthiazole (4)
  • Step 1 Formation of vinylogous amide (5B)
  • Synthetic DNA oligomers were designed that encode the amino terminus of the Akt3 polypeptide to be generated.
  • the design included an initiation Methionine, poly-Histidine purification tag, and a TEV protease cleavage site.
  • the oligos SEQ ID NO:4 and SEQ ID NO:5 were designed to be compatible with Nco restriction site at the 5-prime end and Pstl at the 3-prime end.
  • the oligos also contained the Sapl restriction site, on the bottom strand, adjacent to the Pstl site. Both oligos contain a 5 prime terminal phosphate.
  • the oligos are annealed and then ligated into Litmus 28 vector (New England Biolabs) previously cut Nco/Pst.
  • the Litmus 28 vector was chosen because it has an extensive poly linker and lacks the Sapl site.
  • step 3 The resulting vector of step 2 was then digested SapI/EcoRl .
  • Akt-3 cDNA can be obtained from Open Biosystems (catalog # RHS 1271-8962006).
  • the 5- ⁇ rime PCR primer (SEQ ID NO:6) contains a Sapl cloning site, top strand.
  • Two 3-prime PCR primers were used. Each 3-prime prime contains translation "stop" codon and EcoRl cloning site.
  • One of the 3-prime PCR primers encodes wild-type (SEQ ID NO:7) and the other primer encodes the S472D substitution (SEQ ID NO:8).
  • step 8 The plasmids generated in step 8 were then digested Nco/EcoRl and the resulting fragments were cloned into pAcC4 previously cut Nco/EcoRl .
  • the resulting plasmids are the final expression vectors.
  • Protein production involved infection of suspended Tn5 (Trichoplusia ni) cells in protein-free media at multiplicity of infection (moi) of 2-10 for 48 hours.
  • Cell pellets containing the expressed AKT3 protein were collected by centrifugation at 1200 rpm, chilled for 10 minutes, and immediately frozen.
  • Akt3 polypeptides were purified according to the following procedure:
  • lysis buffer A 20 mM HEPES pH 7.5, 137JnMNaO, 1% Triton X-100, 15% Glycerol, 5 mM beta-mercaptoethanol (b-ME), 2 Complete EDTA-free Protease Inhibitor Tablets (Roche), 100 ug/ml each leupeptin and E-64 (Alexis Biochemicals), and optionally 10-50 ug/ml Pepstatin A (Roche). Complete thaw by stirring at RT.
  • the gradient profile should include a 50 ml wash at 10% C and 10-75% C linear gradient over 200 ml, concluding with a 75-100% C gradient over 20 ml. 5 ml fractions should be collected. Add EDTA to 1 mM and DTT to 10 mM into the fractions. Fractions are pooled according to SDS-PAGE, with a confirmatory Western Blot using Penta-His (Qiagen) as the primary antibody if necessary.
  • Akt3 and mutant (T305D and S472D) Akt3 crystals were grown at 18 0 C using the hanging drop vapor diffusion method.
  • the initial concentrations of the precipitating solution containing the purified Akt3 or Akt3 mutant were 13.4 mg/mL of Akt3 in 20 mM PPES pH 6.8, 15OmM NaCl, 10% glycerol, 10 mM DTT, ImM EDTA, 14%-20% PEG 4000, 50-200 mM CH 3 COOIvIH 4 , and 01.M CH 3 COONa pH 4.5-4.9.
  • the wild type kinase domain Akt3 crystals diffract to approximately 2.5 A resolution using a CuKa X-ray radiation source having the orthorhombic space group P2 1 2i2 1 .
  • the Akt3 and mutant (T305D and S472D) Akt3 crystals were solved by molecular replacement using the program EPMR. These crystals diffract to resolutions between 2.5-1.9 A depending on the crystal and X-ray radiation source.
  • Co-crystals were obtained by co-crystallization of the compound with the protein at 3-fold molar excess and also by soaking the compound (3.0 mM DMSO) into the Akt3 or the mutant (T305D and S472D) Akt3 crystals.
  • the Akt3 co-crystal structures were solved by molecular replacement using the program EPMR with the Akt3 or the mutant (T305D and S472D) Akt3 coordinates as the search model.
  • the coordinates from the molecular replacement solution were subjected to simulated annealing, energy minimization, and individual B-factor refinement using the programs from the CNX suite of programs (Accelrys, San Diego, CA).
  • the refined coordinates were used to calculate the 2Fo-Fc and Fo- Fc omit maps that were visualized in the program O. Additional rounds of refinement of the co-crystal structures were carried out using the programs in the CNX suite.
  • crystallization methods including, for example, microcrystallization methods can be utilized to obtain three-dimensional structural information useful in identifying possible therapeutic compounds in the treatment of various disease conditions mediated by Akt3 activity.
  • Akt3 kinase activity is measured using either a [ ⁇ 33 P]-ATP-based radiometric assay or an antibody-based, time-resolved fluorescence assay, which measures the level of phosphorylation of a biotin-labeled peptide in the presence of Akt3 kinase.
  • the reagents used in these assays, and the procedures for performing the assays, are described below.
  • Recombinant human Akt3 Histag full length Akt3 protein was expressed in insect cells and purified on Ni affinity resin.
  • Biotin-peptide substrate Biotin-Gly-Gly-Gly-Gly-Gly-Arg-Pro-Arg-Ala-Ala-Thr-Phe- NH 2 (American Peptide Company, Sunnyvale, CA); SEQ ID NO:11
  • Assay buffer (50 mM Tris-HCl (pH 7.5), 10 mM MgCl 2 , 5 mM MnCl 2 , 5 mM BGP, 2 mM DTT, and 0.01% BSA)
  • Test compounds are diluted in DMSO to 50 times the final assay concentration. 2 ⁇ l of each diluted test compound are then transferred to a 96-well plate and diluted with freshly prepared assay buffer to a final volume of 25 ⁇ l. 50 ⁇ l assay buffer comprising, 3 nM Akt3 enzyme and 1 ⁇ M biotin-peptide substrate, are then added to the diluted test compounds. The reaction is started by the addition of 25 ⁇ l of 800 nM ATP in assay buffer, resulting in final concentrations of 1.5 nM enzyme, 0.5 ⁇ M biotin-peptide substrate, and 200 nM ATP.
  • Radiometric assays are performed using conditions similar to those described for the time resolved fluorescence assay, except that [ ⁇ 33 P]-ATP is added at the start of each reaction to a final concentration of 5 ⁇ Ci/ml.
  • the reactions are stopped by the addition of EDTA and 100 ⁇ l of each reaction is transferred to 96- well, streptavidin-coated Flashplates (PerkinEhner), to capture the biotin-peptide substrate. After 1 hour, the plates are washed, sealed, and the amount of incorporated 33 P is determined using a Wallac MicroBeta Trilux plate counter.
  • Atomic coordinates of the Akt3 and Akt3 (T305D and S472D) mutant crystals are shown below in Tables 1 and 2 respectively.
  • Atomic coordinates of Akt3 complexed to N-[6-(ammomethyl)-4-chloro-l,3-benzothiazol-2-yl]-5-(2- aminopyrimidin-4-yl)thiophene-2-carboxamide andN-[(lS)-2-amino-l-(2,4- dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide are shown in Tables 3 and 4 respectively.
  • Table 5 shows the atomic coordinates of the Akt3 (T305D and S472D) mutant complexed to N-[(lS)-2-amino-l-(2,4- dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide.
  • the abbreviation “INH” refers to an Akt3 binding compound or inhibitor.
  • the abbreviations "TIP”, “OH2”, and “HOH” refer to a water molecule.
  • the abbreviation “GOL” refers to a glycerol molecule.

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Abstract

The present invention relates to the compositions, crystals, and the three dimensional structures of Akt3 and its mutants, to methods for forming the crystals, and to methods for using the three dimensional structures to design and identify therapeutic compounds for the treatment of Akt3 mediated diseases.

Description

AKT3 COMPOSITIONS AND METHODS OF USE
BACKGROUND OF THE INVENTION
1. Field Of The Invention
[0001] The present invention relates to the compositions, crystals, and the three dimensional structures of Akt3 and its mutants, to methods for forming the crystals, and to methods for using the three dimensional structures to design and identify therapeutic compounds for the treatment of Akt3 mediated diseases.
2. State of the Art
References
[0002] The following literature publications are cited in this section. All of the identified publications are herein incorporated by reference in their entirety to the same extent as if each individual publication was specifically and individually incorporated by reference in its entirety.
Alessi, D.R.; Caudwell, F.B.; Andjelkovic, M.; Hemmings, B.A.; Cohen, P.
(1996) Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase- 1 and p70 S6 kinase. FEBS Lett.
399:333-38. Brazil, D.P. and Hemmings, B.A. (2001) Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26:651 '-64. Don, J., Stelzer, G. (2002) The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis. MoI Cell
Endocrinol. 187:115-24. Harris, T.K. (2003) PDKl and PKB/Akt: ideal targets for development of new strategies to structure-based drug design. IUBMB Life. 55:117-26. Huang, X.; Begley, M.; Morgenstern, K. A.; Gu, Y.; Rose, P.; Zhao, H.; Zhu,
X. (2003) Crystal Structure of an Inactive Akt2 Kinase Domain.
Structure 11:21-30. Lewin, B. ed. (1997) Genes VI, Oxford University Press.
Lawlor, M. A. and Alessi, D.R. (2001) PKB/Akt: a key mediator of cell proliferation, survival and insulin responses. J Cell ScL 114:2903-10. Luckow, V. A. and Summers, M. D. (1988) Trends in the development of baculovirus expression vectors. BIO/TECHNOLOGY, 6:47-55. Luo, J.; Manning, B.D.; Cantley, L.C. (2003) Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 4:257-62. Masure, S.; Haefner, B.; Wesselink, J.; Hoefnagel, E.; Mortier, E.; Verhasselt,
P.; Tuytelaars, A.; Gordon, R.; Richardson, A. (1999) Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. Eur. J. Biochem. 265:353-360. Nakatani, K.; Thompson, D. A.; Barthel, A.; Sakaue, H.; Liu, W.; Weigel, R.
J.; Roth, R. A. (1999) Up-regulation of Akt3 in Estrogen-deficient
Breast Cancers and Androgen-independent Prostate Cancer Lines. J.
Biol. Chem. 274:21528-32. Obata, T.; Yaffe, M.B.; Leparc, G.G.; Piro, E.T.; Maegawa, H.; Kashiwagi,
A.; Kikkawa, R.; Cantley, L.C. (2000) Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J. Biol.
Chem. 275:36108-15. Powell, DJ.; Hajduch, E.; Kular, G.; Hundal, H.S. (2003) Ceramide disables
3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. MoI.
Cell. Biol. 23:7794-808. Radin, N.S. (2003) Killing tumours by ceramide-induced apoptosis: a critique of available drugs. Biochem. J. 371:243-56. Scheid, M.P. and Woodgett, J.R. (2003) Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett. 546:108-12. Staal, S.P. and Hartley, J. W. (1988) Thymic lymphoma induction by the
AKT8 murine retrovirus. J. Exp. Med. 167:1259-64. Tierney, E.P., Tulac, S., Huang, ST., and Giudice, L.C. (2003) Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulation. Physiol. Genomics.
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Humphreys, S.; Alessi, D.R. (2003) WNKl, the kinase mutated in an inherited high blood pressure syndrome, is a novel PKB/ Akt substrate.
Biochem. J. [Nov 11, 2003, electronic publication ahead of printed version]. Walker, K. S.; Deak, M.; Paterson, A.; Hudson, K.; Cohen, P.; and Alessi, D.
R. (1998) Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparision with protein kinase B α. Biochem. J 331 :299-308. Watson, J.D. et ah, eds. (1987) Molecular Biology of the Gene,
Benjamin/Cummings Pub. Co., Inc.. Yang, J.; Cron, P.; Good, V. M.; Thompson, V.; Hemmings, B. A.; Barford,
D. (2002) Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP. Nature
Structural Biology Vol. 9, no. 12, pg. 940-944.
[0003] vAkt was first identified as a cell-derived, viral oncogene present in the transforming murine leukemia retrovirus, AKT8 (Staal and Hartley, 1988). The virus was unusual in its ability to transform mink lung epithelial cells but not other cells, such as NIH3T3 fibroblasts, suggesting the presence of a novel, cell-type specific oncogene. Protein kinase B (PKB), a serine/threonine protein kinase belonging to the AGC protein kinase superfamily, was identified as the cellular homologue of Akt, giving rise to the current "PKB/Akt" nomenclature system (Brazil and Hemmings, 2001 ; and references within). At least three cellular homologues have now been identified {i.e., Aktl/ PKBα, Akt2/ PKBβ, and Akt3/ PKBγ) (Lawlor and Alessi, 2001 ; Scheid and Woodgett, 2003).
[0004] PKB/Akt was later shown to mediate downstream events associated with phosphatidylinositol 3-kinase (PI3K), which is recruited to the plasma membrane in response to growth factors (including platelet-derived growth factor (PDGF), epidermal growth factor (EGF)5 basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF-I), nerve growth factor (NGF), stem cell factor, and vascular endothelial growth factor), cytokines (including interleukins 2, 3, 4, 5, and 8), insulin, bradykinin, RANTES, and endothelin, as well as attachment to the extracellular matrix (ECM) and various forms of cell stress (e.g., hypoxia and heat shock) (Lawlor and Alessi, 2001; Brazil and Hemmings, 2001; Scheid and Woodgett, 2003).
[0005] At the plasma membrane, PI3K converts phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2; PIP2) to the lipid second-messenger, phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3; PIP3). PIP3, or its breakdown product, phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P3; PI(3,4)P2), recruits PKB/ Akt to the plasma membrane via the N-terminal, pleckstrin homology (PH) region of PKB.
[0006] In addition to the PH region, the PKB/Akt proteins are known to possess a docking domain (HM) for their upstream activating kinase, 3-phosphoinoside- dependent kinase (PDKl), also an AGC family kinase. The HM domain also appears to function as a site for other means of allosteric regulation (Scheid and Woodgett, 2003).
[0007] Membrane bound PKB is activated by multi-site phosphorylation, particularly within the activation T-loop of the central catalytic domain. Phosphorylation at a threonine residue (Thr308 of PKBα, Thr309 of PKBβ, Thr305 of PKBγ), situated within the activation T-loop, appears to be performed by PDKl, and is necessary for PKB activity. Phosphorylation at a serine residue (Ser473 of PKBα, Ser474 of PKBβ, Ser472 of PKBγ), located at the C-terminal hydrophobic domain of PKB, is also important for maximum PKB activity, although the mechanism of phosphorylation is not clear (Brazil and Hemmings, 2001; Scheid and Woodgett, 2003).
[0008] Phosphorylated PKB then participates in a number of downstream signaling events related to cell cycle regulation, survival, motility and growth (Lawlor and Alessi, 2001; Scheid and Woodgett, 2003). These processes are essential for normal cell function. In addition, mutations and/or aberrant expression of polypeptides affecting the activity and/or production of phosphorylated PKB have been implicated in human cancer (Luo et ah, 2003).
[0009] The individual Akt isoforms further show cancer dependent expression levels. Aktl has been found to be overexpressed in gastric adenocarcinomas. Akt2 overexpression is found in breast, ovarian, and pancreatic cancers. Akt3 has recently been found to be overexpressed in estrogen negative breast cancers and androgen- insensitive prostate carcinomas (Nakatani et. al, 1999). Unlike Aktl and Akt2, Akt3 is expressed in a limited number of tissues. Such preferential expression has generated interest in Akt3 as an attractive target for small molecule inhibition (Walker, et. al. 1998).
[0010] Akt3 shows approximately an 83% protein sequence identity to Aktl and a 78% identity to Akt2 (Masure et. al., 1999). A crystal structure of Akt2/PKBβ containing amino acid residues 143-481 has been determined (Huang, X. et. al. 2003). In this protein, Thr309 and Ser474 were unphosphorylated, which was found to reduce its activity. Other truncated Akt2/PKBβ crystal structures are also known. WO 03/016516 discloses Akt2 crystals having residues 146-460, with Thr309 either phosphorylated or unphosphorylated, as well as crystals having residues 146-481. Crystal structures of Akt2 having residues 146-467 fused to PIF (a 23 residue peptide containing the hydrophobic motif of the AGC kinase PRK2) and an Akt2-PIF chimeric protein further containing a S474D substitution are also known (Yang, et. al. 2002 and WO03/016517). Despite the recent disclosures of Akt2 crystals, no known Akt3 crystal structures have been reported.
[0011] Accordingly, the need exists for inhibitors of Akt3. Techniques such as structure based drug design would be helpful in the development and identification of Akt3 inhibitors. The use of such a strategy would be greatly facilitated if the crystal structures of Akt3 and Akt3 bound to an inhibitor are known.
SUMMARY OF THE INVENTION [0012] The present invention provides various Akt3 compositions such as Akt3 polypeptides and crystals, and methods for producing Akt3 crystals. The invention further provides methods for using the atomic coordinates corresponding to the crystal structures of Akt3 and its complexes to design and identify therapeutic compounds for the treatment of Akt3 mediated diseases.
[0013] Thus in some embodiments, the invention provides an Akt3 polypeptide crystal that is resolvable using X-ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination of the Akt3 polypeptide. In other embodiments, the Akt3 polypeptide has at least a 90% amino acid sequence identity to residues 138 to 479 of SEQ ID NO:1 or SEQ ID NO:2. In yet another embodiment the sequence identity is at least 95%. Ih still another embodiment, at least one of the Akt3 amino acid residues 305 or 472 is an aspartic amino acid.
[0014] In a further embodiment, the invention provides an Akt3 crystal, having the atomic coordinates set forth in Table 1, of an Akt3 polypeptide corresponding to SEQ ID NO:1. In another embodiment, the invention provides an Akt3 crystal, having the atomic coordinates set forth in Table 2, of an Akt3 mutant polypeptide having T305D and S472D substitutions corresponding to SEQ ID NO:2.
[0015] In yet another embodiment, the invention provides a co-crystal of an Akt3 polypeptide complexed to an Akt3 binding compound wherein the co-crystal is resolvable using X-ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination of the Akt3 complex. In one such embodiment, the invention provides an Akt3 co-crystal having the atomic coordinates set forth in Table 3, of an Akt3 polypeptide complexed to N-[6-(aminomethyl)-4-chloro-l,3- benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide. In still another embodiment, the invention provides an Akt3 co-crystal having the atomic coordinates set forth in Table 4, of an Akt3 polypeptide complexed to N-[(lS)-2- amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thioρhene-2- carboxamide. In another embodiment, the invention provides an Akt3 co-crystal having the atomic coordinates set forth in Table 5, of an Akt3 mutant polypeptide having T305D and S472D substitutions and complexed to N-[(lS)-2-amino-l-(2,4- dichlorobenzyl)ethyl]-5-[2-(methylamino)pyriniidin-4-yl]thiophene-2-carboxamide.
[0016] The present invention further provides a method for crystallizing an Akt3 polypeptide complexed to a compound, comprising: (a) providing an Akt3 polypeptide; (b) contacting the Akt3 polypeptide with a compound; and (c) crystallizing the Akt3 polypeptide and compound from a solution to provide a crystallized complex, wherein the crystallized complex is resolvable using X-ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination.
[0017] In some embodiments of the method for crystallization, the Akt3 polypeptide comprises amino acid residues 138-479 of SEQ ID NO:1. In other embodiments, the Akt3 polypeptide comprises amino acid residues 138-479 of SEQ ID NO:2. hi yet another embodiment the Akt3 polypeptide provided is an Akt3 polypeptide crystal.
[0018] In another embodiment, the present invention provides a method for evaluating the ability of a compound to associate with an Akt3 polypeptide, the method comprising the steps of: (a) providing a three dimensional Akt3 structure using at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5, wherein the atomic coordinate root mean square deviation is less than 3.θA; (b) providing a three dimensional compound structure of said compound; (c) employing a fitting process to dock or superimpose said three dimensional compound structure onto said three dimensional Akt3 structure; and (d) analyzing the results of said fitting process.
[0019] In yet another embodiment, the present invention provides a method for identifying a compound capable of modifying Akt3 activity, the method comprising the steps of: (a) providing a three dimensional Akt3 structure using at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5, wherein the atomic coordinate root mean square deviation is less than 3.θA; (b) providing a three dimensional compound structure of said compound; (c) employing a fitting process to dock or superimpose said three dimensional compound structure onto said three dimensional Akt3 structure; (d) analyzing the results of said fitting process; (e) synthesizing the compound; and (f) contacting the compound with an Akt3 polypeptide to determine the ability of the compound to modify Akt3 activity.
[0020] In some embodiments, the root mean square deviation of the atomic coordinates in Tables 1, 2, 3, 4, or 5, is less than 2.5A. In other embodiments, the root mean square deviation is less than 2.0A. In yet other embodiments the root mean square deviation is less than 1.θA. In still other embodiments the root mean square deviation is less than 0.5A. In yet other embodiments the root mean square deviation is less than 0.1 A.
[0021] In other embodiments of the methods of the invention, the three dimensional Akt3 structure has at least the amino acids set forth in Tables 6, 7, 8, 9, 10, or 11.
[0022] In yet other embodiments of the methods of the invention, the three dimensional compound structure associates with one or more amino acid set forth in Tables 6, 7, 8, 9, 10, or 11. In other embodiments, the three dimensional compound structure is a known kinase inhibitor or portion thereof. In still other embodiments, the three dimensional compound structure or portion thereof is N-[(lS)-2-amino-l- (2,4-dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2- carboxamide or N-[6-(aminomethyl)-4-chloro-l ,3-benzothiazol-2-yl]-5-(2- aminopyrimidin-4-yl)thiophene-2-carboxamide. In yet other embodiments, the three dimensional compound structure is selected from a database, hi a further embodiment, the three dimensional compound structure is designed de novo. hi some embodiments, the compound is a competitive ATP inhibitor.
[0023] The present invention also provides a computer for producing a three- dimensional representation of a molecule or molecular complex, wherein the computer comprises: (a) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5; (b) a working memory for storing instructions for processing said machine-readable data; (c) a central-processing unit coupled to said working memory and to said machine- readable data storage medium for processing said machine readable data into said three-dimensional representation; and (d) a means for displaying said three- dimensional representation.
[0024] The present invention further provides a computer for determining at least a portion of the atomic coordinates corresponding to an X-ray diffraction pattern of a molecule or molecular complex, wherein said computer comprises: (a) a machine- readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5; (b) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises an X-ray diffraction pattern of said molecule or molecular complex; (c) a working memory for storing instructions for processing said machine-readable data of (a) and (b); (d) a central-processing unit coupled to said working memory and to said machine-readable data storage medium of (a) and (b) for performing a Fourier transform of the machine readable data of (a) and for processing said machine readable data of (b) into structure coordinates; and (e) a display coupled to said central-processing unit for displaying said structure coordinates of said molecule or molecular complex.
BRIEF DESCRIPTION OF THE DRAWINGS
[0025] The foregoing aspects and many of the attendant advantages of this invention will become more readily appreciated by reference to the following detailed description, when taken in conjunction with the accompanying figures. Figures 1-5 were rendered using the program Quanta (Accelrys; San Diego, CA) from the indicated atomic coordinates. The N-terminus is located as indicated in the lower right hand corner for all the figures.
[0026] Figure 1 shows the crystal structure of Akt3 (2.5 Angstroms) corresponding to the atomic coordinates in Table 1. [0027] Figure 2 shows the crystal structure of the Akt3 (T305D and S472D) mutant (1.95 Angstroms) corresponding to the atomic coordinates in Table 2.
[0028] Figure 3 shows the crystal structure of Akt3 complexed to N- [6- (aminomethyl)-4-chloro-l,3-benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene- 2-carboxamide (2.4 Angstroms) corresponding to the atomic coordinates in Table 3.
[0029] Figure 4 shows the crystal structure of Akt3 complexed to N-[(l S)-2- amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2- carboxamide (2.5 Angstroms) corresponding to the atomic coordinates in Table 4.
[0030] Figure 5 shows the crystal structure of the Akt3 (T305D and S472D) mutant complexed to N-[(lS)-2-amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2- (methylamino)pyrirnidin-4-yl]thiophene-2-carboxamide (2.35 Angstroms) corresponding to the atomic coordinates in Table 5.
DETAILED DESCRIPTION OF THE INVENTION
[0031] It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of the present invention. It must be noted that as used herein and in the claims, the singular forms "a," "and" and "the" include plural referents unless the context clearly dictates otherwise.
[0032] In this specification and in the claims that follow, the term "Akt3 polypeptide" refers to the native protein, mutants, variants, and portions thereof. Akt3 mutants include proteins arising from replacement of one or more amino acid residues in the native protein with different amino acid residues. Akt3 variants also include chimeric or fusion proteins.
[0033] The term "three dimensional Akt3 structure" refers to the three dimensional representation of the Akt polypeptide as well as to the three dimensional representation of Akt3 polypeptide complexed to a compound. [0034] The term "Akt3 binding compound" refers to compounds capable of binding to Akt3 and altering its activity. Akt3 binding compounds include compounds disclosed in WO 2004/007498, WO 2004/007499, WO 03/076429, WO 03/064397, WO 03/091246, WO 02/22610, WO 01/56993, WO 01/57022, WO 02/50065, WO 03/051366, WO 04/016597, and US provisional application 60/558342 filed March 30, 2004. The disclosures of these applications are incorporated by reference and for all purposes as if fully set forth therein.
[0035] The one or three letter amino acid residue abbreviations are shown below.
Figure imgf000012_0001
[0036] SEQ ID NO: 1 below refers to the expressed Akt3 polypeptide. SEQ
ID NO: 2 refers to the double mutant (T305D and S472D) Akt3 polypeptide, wherein the respective threonine and serine amino acid residues are replaced with aspartic acid residues. Both polypeptide sequences start with the N-terminal initiation Met (M) followed by Ala (A) which was included for ease of cloning. Next is the 6x His (H) purification tag. After the tag comes the Tev processing site, Glu-Asn-Leu-Tyr-Phe- Gln-Gly (ENLYFQG). The remainder of the polypeptide residues are numbered Tl 38 to E479 in accordance with the numbering convention used in the Akt3 GenBank accession number NP_005456 (amino acid residues 1-479 of NP_005456 is shown in SEQ ID NO:3).
SEQ ID NO : 1
MAHHHHHHENLYFQGTHHKRKTMNDFDYLKLLGKGTFGKVILVREKΆSGKYYAMKIL KKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFH LSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLC KEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGWMYEMMCGRLPFYNQD HEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSG
VNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER
RPHFPQFSYSASGRE
SEQ ID NO:2
MAHHHHHHENLYFQGTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKIL KKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFH LSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLC KEGITDAATMKDFCGTPEYLAPEVLEDNDYGRAVDWWGLGWMYEMMCGRLPFYNQD HEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSG VNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER RPHFPQFDYSASGRE
SEQ ID NO:3
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVA KCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEE ERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASG KYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYV NGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHI KITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGWMYEMMCG RLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI MRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDG MDCMDNERRPHFPQFSYSASGRE
Akt3 crystals and co-crystals
[0037] The thiophene N-[(lS)-2-amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2- (methylamino)pyrimidin-4-yl]thiophene-2-carboxamide (1) and N-[6-(aminomethyl)- 4-chloro-l,3-benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide (3) shown below were synthesized as shown in Examples 1 and 2 respectively. The Akt3 polypeptides were expressed and purified as shown in Examples 3 and 4 respectively. A representative method for forming Akt3 crystals is described in Example 5. Examples 6 describes a method for assaying a compound for Akt3 activity.
Figure imgf000014_0001
N-[(lS)-2-amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4- yl]thiophene-2-carboxamide (1) and N-[6-(aminomethyl)-4-chloro-l,3-benzothiazol- 2-yl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide (3)
Example 1
Scheme 1. Synthesis of N-[(lS)-2-amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2- (methylamino)pyrimidin-4-yl]thiophene-2-carboxamide (1)
M
Figure imgf000014_0002
1A 1B
Figure imgf000014_0003
Step 1: Protection as t-butyl carbamate (IB)
[0038] Di-tert-butyldicarbonate (1.2 eq), 4-dimethylaminopyridine (0.2 eq), and triethylamine (1.2 eq) were added to a 0.5 M solution of compound IA (see Scheme 5 for synthesis of IA) in tetrahydrofuran. The mixture was stirred 16 h at ambient temperature. The mixture was diluted with ethyl acetate and washed sequentially with water and brine. The organic phase was dried over sodium sulfate, filtered, and concentrated to give compound IB which was used without further purification. ES/MS m/z 364 (MH+), CnH21N3O4S = 363 g/mol.
Step 2: Saponification to cafboxylic acid (1C)
[0039] Aqueous sodium hydroxide (2.0 eq) was added to a 0.2 M solution of compound IB in ethanol. The mixture was stirred for 16 h at ambient temperature. Volatiles were removed under reduced pressure. The residue was re-dissolved in dichloromethane and washed sequentially with dilute aqueous hydrochloric acid and brine. The organic phase was dried over sodium sulfate, filtered, and concentrated to give compound 1C which was used without further purification. ES/MS m/z 336 (MH+), C15H17N3O4S = 335 g/mol.
Step 3: Condensation to amide (ID)
[0040] N,N'-Carbonyldiimidazole (1.0 eq) was added to a 0.2 M solution of compound 1C in anhydrous tetrahydrofuran. The mixture was stirred for 3 h at 50 0C. The solution was returned to ambient temperature, and l-azidomethyl-2-(2,4- dichlorophenyl)ethylamine 2 (1.1 eq; see Scheme 2 below for synthesis) was added. The solution was stirred an additional 15 h at 50 0C. The reaction mixture was diluted with one volume of methanol, and 3 M aqueous hydrochloric acid was then added (30 eq). The reaction was stirred 3 h at 50 0C. Volatiles were removed under reduced pressure. The residue was re-dissolved in dichloromethane and washed sequentially with water and brine. The organic phase was dried over sodium sulfate, filtered, and concentrated to give compound ID which was used without further purification. ES/MS m/z 462 (MH+), C19H17Cl2N7OS = 462 g/mol. Step 4: Hydrogenolysis to free amine (1)
[0041] A reaction vessel containing a 0.05 M solution of compound ID was purged with argon. A catalytic amount of 10% wt palladium on carbon was added. The reaction vessel was purged with hydrogen, and the reaction was stirred at ambient temperature for 3 h. The palladium was removed by filtration, and the filtrate was concentrated under reduced pressure. The crude material was purified by reverse- phase HPLC to give compound 1. ES/MS m/z 436 (MH+), C19H19Cl2N5OS = 436 g/mol.
Scheme 2. Synthesis of l-azidomethyl-2-(2,4-dichlorophenyl)ethylamine (2)
Figure imgf000016_0001
2A 2B 2C
Figure imgf000016_0002
2 2D
Step 1 : Reduction to aminoalcohol (2B)
[0042] A 1.0 M solution of lithium borohydride (2.0 eq) in tetrahydrofuran was cooled to 0 °C. Chlorotrimethylsilane (4.00 eq) was added dropwise. The mixture was stirred for 20 min at ambient temperature and then returned to 0 °C. 2,4- dichloro-L-phenylalanine 2 A (1.0 eq) was added. The reaction was allowed to return to ambient temperature while stirring overnight. The mixture was cooled to 0 0C and quenched by the slow addition of methanol followed by 2 N aqueous sodium hydroxide (2 eq). Volatiles were removed under reduced pressure. The slurry was diluted with water and extracted with dichloromethane. The combined organic extracts were washed with brine, dried over sodium sulfate, filtered, and concentrated to give compound 2B that was used without further purification. ES/MS m/z 220 (MH+), C9H11Cl2NO = 220 g/mol.
Step 2: Protection as t-butyl carbamate (2C)
[0043] A 0.4 M solution of compound 2B (1.0 eq) in chloroform was cooled to 0 0C. Di-tert-butyl-dicarbonate (1.0 eq) was added. The solution was stirred overnight at ambient temperature. Volatiles were removed under reduced pressure. The material was purified by flash chromatography over silica gel (49:49:2 dichloromethane : ethyl acetate : methanol) to give compound 2C. ES/MS m/z 320 (MH+), C14H19Cl2NO3 = 320 g/mol.
Step 3: Mitsunobu to azide (2D)
[0044] A 0.3 M solution of compound 2C (1.0 eq) in tetrahydrofuran was cooled to 0 0C. Triphenylphosphine (1.1 eq) was added. A solution of diethylazodicarboxylate (1.0 eq) in toluene was added dropwise over 15 min. Diphenylphosphoryl azide (1.1 eq) was added, and the reaction was allowed to return to ambient temperature while stirring overnight. Volatiles were removed under reduced pressure. The material was purified by flash chromatography over silica gel (2:1 hexanes : ethyl acetate) to give compound 2D. ES/MS m/z 345 (MH+), C14H18Cl2N4O2 = 345 g/mol.
Step 4: Deprotection to free amine: l-azidomethyl-2-(2,4-dichlorophenyl)ethylamine (2)
[0045] A 0.1 M suspension of compound 2D in 1:1 methanol : 3 M aqueous hydrochloric acid was stirred overnight at 50 °C. The solution was brought to ambient temperature. Volatiles were removed under reduced pressure. The mixture was adjusted to pH 9 with aqueous sodium hydroxide and then extracted with dichloromethane. The combined organic extracts were dried over sodium sulfate, filtered, and concentrated to give compound 2 that was used without further purification. ES/MS m/z 245 (MH+), C9H10Cl2N4 = 245 g/mol.
Example 2 Scheme 3. Synthesis of N-[6-(aminomethyl)-4-chloro-l,3-benzothiazol-2-yi]- 5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide (3).
Figure imgf000018_0001
3A 3B
Figure imgf000018_0002
Step 1 : Protection as t-butyl carbamate (3B)
[0046] Di-tert-butyldicarbonate (2.2 eq), 4-dimethylaminopyridine (0.2 eq), and triethylamine (2.2 eq) were added to a 0.5 M solution of compound 3A (synthesized analogous to compound IA, Scheme 5) in tetrahydrofuran. The mixture was stirred 16 h at ambient temperature. The mixture was diluted with ethyl acetate and washed sequentially with water and brine. The organic phase was dried over sodium sulfate, filtered, and concentrated to give compound 3B which was used without further purification. ES/MS m/z 450 (MH+), C21H27N3O6S = 449 g/mol.
Step 2: Saponification to carboxylic acid (3C)
[0047] Aqueous sodium hydroxide (2.0 eq) was added to a 0.2 M solution of compound 3B in ethanol. The mixture was stirred for 16 h at ambient temperature. Volatiles were removed under reduced pressure. The residue was re-dissolved in dichloromethane and washed sequentially with dilute aqueous hydrochloric acid and brine. The organic phase was dried over sodium sulfate, filtered, and concentrated to give compound 3 C which was used without further purification. ES/MS m/z 422 (MH+), C19H23N3O6S = 421 g/mol.
Step 3: Condensation to amide (3) [0048] N,N'-Carbonyldiimidazole (1.00 eq) was added to a 0.2 M solution of compound 3C in anhydrous 1,4-dioxane. The mixture was stirred for 3 h at 6O0C. The solution was returned to ambient temperature, and 2-amino-6-(N-Boc- amino)methyl-4-chlorobenzthiazole 4 (1.1 eq, see Scheme 4 for synthesis) was added. The solution was stirred an additional 42 h at 100 °C. The reaction mixture was diluted with one volume of methanol, and 3 M aqueous hydrochloric acid was added (30 eq). The reaction was stirred 21 h at 60 °C. Volatiles were removed under reduced pressure. The residue was purified by reversed-phase HPLC and lyophilized to give compound 3 as its bistrifluoroacetic acid salt. ES/MS m/z All (MH+), C17H13ClN6OS2 = 416 g/mol.
Scheme 4. Synthesis of 2-amino-6-(N-Boc-amino)methyl-4-chlorobenzthiazole (4).
Figure imgf000019_0001
Step 1: Synthesis of isothiocyanate (4B)
[0049] Thiophosgene (1.1 eq) was added to a 0.5 M suspension of 4-amino-3- chloro-benzonitrile 4A (1.00 eq) in toluene. The mixture was stirred at 110 0C for 16 h. Volatiles were removed under reduced pressure to give compound 4B which was used without further purification. ES/MS m/z 195 (MH+), C8H3ClN2S = 194 g/mol.
Step 2: Synthesis of thiourea (4C)
[0050] Compound 4B (1.0 eq) was suspended in 1,4-dioxane. Concentrated ammonium hydroxide (2.0 eq) was added. The mixture was stirred for 30 min at ambient temperature. The slurry was concentrated to about half of its original volume and then filtered. The precipitate was rinsed with ether and then dried in a desiccator while under reduced pressure to give compound 4C. ES/MS m/z 212 (MH+), C8H6ClN3S = 21 l g/mol.
Step 3: Cyclization to 6-cyanobenzthiazole (4D)
[0051] A 0.6M solution of bromine (1.5 eq) in chloroform was added over 15 min. to a 0.4 M suspension of compound 4C (1.0 eq) in chloroform at ambient temperature. The mixture was stirred at 75 °C for 16 h and then returned to ambient temperature. The precipitate was collected and crushed to a fine powder. This material was returned to the filtrate. Additional bromine (0.5 eq) was added; and the mixture was stirred at 75 0C for 46 h. The reaction mixture was returned to ambient temperature and filtered. The precipitate was rinsed with ether and dried under reduced pressure to give compound 4D as its HBr salt. ES/MS m/z 210 (MH+), C8H4ClN3S = 209 g/mol.
Step 4: Reduction to 6-aminomethylbenzthiazole (4E)
[0052] Compound 4D (1.00 eq) was added to a 0.4M suspension of lithium aluminum hydride (4.00 eq) in ether at 0 0C. The slurry was stirred overnight at ambient temperature. The mixture was returned to 0 0C and quenched with water. The layers were separated. The aqueous phase was adjusted to pH 10-11 and then extracted with dichloromethane. The combined organic phases were dried over sodium sulfate, filtered, and concentrated to give compound 4E which was used without further purification. ESMS m/z 214 (MH+), C8H8ClN3S = 213 g/mol.
Step 5: Conversion to N-Boc-aminomethylbenzthiazole (4)
[0053] Di-tertbutyl-dicarbonate (1.0 eq) was added to a 0.1 M suspension of compound 4E in tetrahydrofuran and stirred for 1 h at ambient temperature. Volatiles were removed under reduced pressure. The material was purified by flash chromatography over silica gel (48:48:4 dichloromethane:ethyl acetate:methanol) to give compound 4. ES/MS m/z 314 (MH+), Ci3Hi6ClN3O2S = 313 g/mol. Scheme 5. Synthesis of 5-(2-methylamino-pyrimidin-4-yl)-thiophene-2-carboxylic acid ethyl ester IA
Figure imgf000021_0001
5A 5B
Figure imgf000021_0002
1A
Step 1 : Formation of vinylogous amide (5B)
[0054] Dimethylformamide dimethyl acetal (2.50 eq.) was added to a 0.30 M solution of compound 5A (1.00 eq.) in anhydrous toluene. The reaction was refluxed for 15 h and then returned to ambient temperature. The product was precipitated by the addition of 1 : 1 ether: hexanes and isolated by vacuum filtration. The filter cake was rinsed with additional 1:1 ether: hexanes and then dried under reduced pressure to give compound 5B as a tan solid. ES/MS m/z 240 (MH+), C11H13NO3S = 239 g/mol.
Step 2: Cyclization to aminopyrimidine TlA)
[0055] Sodium ethoxide (2.10 eq.) and methylguanidine hydrochloride (2.00 eq.) were added to a 0.2 M solution of compound 5B (1.00 eq.) in absolute ethanol at ambient temperature. The mixture was stirred at 70 0C for 16 h. Volatiles were removed under reduced pressure. The slurry was diluted with dichloromethane and washed sequentially with water and brine. The organic phase was dried over sodium sulfate, filtered, and concentrated to give compound IA. ES/MS m/z 264 (MH+), C12H13N3O2S = 263 g/mol.
Example 3
Polypeptide Expression [0056] In this example, the expression of the Akt3 polypeptide and Akt3 (T3O5D S472D) mutant construct is described.
Cloning strategy for the generation of Akt-3 polypeptides and mutants in baculovirus.
[0057] 1. Synthetic DNA oligomers were designed that encode the amino terminus of the Akt3 polypeptide to be generated. The design included an initiation Methionine, poly-Histidine purification tag, and a TEV protease cleavage site. The oligos SEQ ID NO:4 and SEQ ID NO:5 were designed to be compatible with Nco restriction site at the 5-prime end and Pstl at the 3-prime end. The oligos also contained the Sapl restriction site, on the bottom strand, adjacent to the Pstl site. Both oligos contain a 5 prime terminal phosphate.
SEQ ID NO : 4
CATGCCCACCACCACCATCACCACGAGAACCTGTACTTCCAGGGCACCCGAAGAGCC
TGCA
SEQ ID NO : 5 GGCTCTTCGGGTGCCCTGGAAGTACAGGTTCTCGTGGTGATGGTGGTGGTGGGC
[0058] 2. The oligos are annealed and then ligated into Litmus 28 vector (New England Biolabs) previously cut Nco/Pst. The Litmus 28 vector was chosen because it has an extensive poly linker and lacks the Sapl site.
[0059] 3. The resulting vector of step 2 was then digested SapI/EcoRl .
[0060] 4. PCR was performed from an Akt-3 cDNA template to generate two Akt-3 encoding cloning fragment, wild-type and S472D. Akt-3 cDNA can be obtained from Open Biosystems (catalog # RHS 1271-8962006). The 5-ρrime PCR primer (SEQ ID NO:6) contains a Sapl cloning site, top strand. Two 3-prime PCR primers were used. Each 3-prime prime contains translation "stop" codon and EcoRl cloning site. One of the 3-prime PCR primers encodes wild-type (SEQ ID NO:7) and the other primer encodes the S472D substitution (SEQ ID NO:8).
SEQ ID NO : 6 GCTCTTCCACCCACCACAAGAGAAAGACAATGAATG
SEQ ID NO : 7 GAATTCTTATTCTCGTCCACTTGCAGAGTAGGAAAATTGAG
SEQ ID NO:8 GAATTCTTATTCTCGTCCACTTGCAGAGTAGTCAAATTGAG
[0061] 5. The two PCR fragments were cloned into pCR2.1 topo (Invitrogen) vector.
[0062] 6. The Akt3 S472D clone in ρCR2.1 topo was then further mutated. Using Site-directed Mutagenesis (Strategene) the T305D substitution was generated. The oligos used are SEQ ID NO:9 and SEQ ID NO: 10.
SEQ ID NO:9 GATGCAGCCACCATGAAGGAGTTCTGTGGCACTCCAG
SEQ ID NO:10 CTGGAGTGCCACAGAACTCCTTCATGGTGGCTGCATC
[0063] 7. The wild-type fragments resulting from step 6 and the S472D T305D fragment from 7 were then cloned into the vector from step 3. These are the complete coding fragments.
[0064] 8. The plasmids generated in step 8 were then digested Nco/EcoRl and the resulting fragments were cloned into pAcC4 previously cut Nco/EcoRl . The resulting plasmids are the final expression vectors.
[0065] The sequences encoding specific forms of human AKT3 kinase were cloned into the baculovirus transfer vector pAcC4 (Luckow, et. al.) and cotransfected with linearized, BakPak-6 genomic DNA (Clonetech) using methods recommended by the vendor. Subsequently, the recombinant baculovirus obtained from this procedure was subcloned by plaque-purification on adherent Sf9 insect cells to yield several isolates expressing human AKT3. A clone was selected for its exceptional expression characteristics. Amplification of this baculovirus isolate was performed by infecting Sf21 cells at low multiplicity of infection (moi), to generate high-titer, low passage stock for protein production.
[0066] Protein production involved infection of suspended Tn5 (Trichoplusia ni) cells in protein-free media at multiplicity of infection (moi) of 2-10 for 48 hours. Cell pellets containing the expressed AKT3 protein were collected by centrifugation at 1200 rpm, chilled for 10 minutes, and immediately frozen.
Example 4
Polypeptide Purification
[0067] The expressed Akt3 polypeptides were purified according to the following procedure:
[0068] Thaw frozen insect cell pellet from 2 L of culture in room temperature (RT) water bath until loose from tube. Add to 50 ml lysis buffer A: 20 mM HEPES pH 7.5, 137JnMNaO, 1% Triton X-100, 15% Glycerol, 5 mM beta-mercaptoethanol (b-ME), 2 Complete EDTA-free Protease Inhibitor Tablets (Roche), 100 ug/ml each leupeptin and E-64 (Alexis Biochemicals), and optionally 10-50 ug/ml Pepstatin A (Roche). Complete thaw by stirring at RT. Break cells in a 100 ml Dounce homogenizer (Wheaton) using 10-15 strokes of the tightest plunger. Centrifuge at 18,000 rpm for 45 min. at 4 0C in a Beckman JA-20 rotor. Decant the supernatant as the load for Nickel Column 1.
[0069] Equilibrate a 5-ml HiTrap Chelating Sepharose column charged with nickel ions (GE Healthcare, formerly Amersham) with buffer B: 25 mM HEPES pH 7.4; 0.5 M NaCl; 5% glycerol; 5 mM imidazole; 5 mM b-ME. The flow rate is 5 ml/min. After loading the supernatant, wash to baseline and elute with a gradient to buffer C: 25 mM HEPES pH 7.4; 0.5 M NaCl; 5% glycerol; 200 mM imidazole; 5 mM b-ME. The gradient profile should include a 50 ml wash at 10% C and 10-75% C linear gradient over 200 ml, concluding with a 75-100% C gradient over 20 ml. 5 ml fractions should be collected. Add EDTA to 1 mM and DTT to 10 mM into the fractions. Fractions are pooled according to SDS-PAGE, with a confirmatory Western Blot using Penta-His (Qiagen) as the primary antibody if necessary.
[0070] To the pooled material, add 1000 U TEV Protease (US Biologicals). At 4 C, dialyze the pool against 2 L buffer D: 25mM HEPES pH 7.4, 10 mM NaCl, 5% glycerol, 10 mM DTT, 1 mM EDTA, changing the buffer at least three times over 24 hrs. Remove the pool and assay by LC/MS. If the protein is phosphorylated, dephosphorylate by adding Manganese chloride to 1.5 mM and 8,000-10,000 units lambda phosphatase enzyme (New England Biologicals). Monitor the progress of the TEV protease cleavage by SDS-PAGE or LC/MS. When cleavage is 90-100% complete, proceed to Q-Sepharose Column 2.
[0071] Equilibrate a 5 ml HiTrap Q-Sepharose Fast Flow (GE Healthcare) at 5 ml/min in buffer E: 25 mM HEPES pH 7.4; 100 mM NaCl; 5% glycerol; 5 mM b- ME. Load the cleaved and dephosphorylated Nickel Column 1 Pool. Wash to baseline with buffer E and elute with a gradient to buffer F: 25mM HEPES pH 7.4; 500 mM NaCl; 5% glycerol; 5 mM b-ME. The gradient profile is: 0-25% F in 20 ml, 25-60% F in 200 ml, and 60-100% F in 20 ml. Collect 5-ml fractions and pool by SDS-PAGE. The pool can be loaded directly onto Nickel Column 3.
[0072] Equilibrate a 5-ml HiTrap Chelating Sepharose column charged with nickel ions (GE Healthcare, formerly Amersham) with buffer G: 25 mM HEPES pH 7.4; 0.5 M NaCl; 5% glycerol; 2 mM imidazole; 5 mM b-ME. The flow rate is 5 ml/min. Load the Q-Pool, then wash to baseline and elute with a gradient to buffer H: 25 mM HEPES pH 7.4; 0.5 M NaCl; 5% glycerol; 200 mM imidazole; 5 mM b-ME. The gradient profile 0-100% H over 100 ml. 5 ml fractions should be collected. Add EDTA to 1 mM and DTT to 10 mM into the fractions. Fractions are pooled according to SDS-PAGE. Despite the removal of the His-tag by TEV protease, cleaved Akt3 binds to the Nickel Column, but elutes earlier than the uncleaved material. If necessary, concentrate the pool using a 15 ml Ultra-free centrifugal concentrator (Amicon Millipore) with a 10,000 Dalton membrane. This is the load for Column 4 Superdex 200 size exclusion.
[0073] Equilibrate a Superdex 200 26/60 Size Exclusion column (GE Healthcare) in buffer J: 20 mM PIPES pH 6.8; 100 mM NaCl; 10% glycerol; 10 mM DTT; 0.1 M EDTA. Load up to 5 ml of Nickel Column 3 Pool onto the column at 2.5 ml/min. Collect 2.5 ml fractions. Pool according to UV trace or SDS-PAGE. [0074] Concentrate the Superdex 200 pool to 10-15 mg/ml in an Ultra-free centrifugal concentrator (Amicon Millipore) with a 10,000 Dalton membrane.
Example 5
Crystallization, Co-crystallization, and Resolution
[0075] The Akt3 and mutant (T305D and S472D) Akt3 crystals were grown at 18 0C using the hanging drop vapor diffusion method. The initial concentrations of the precipitating solution containing the purified Akt3 or Akt3 mutant were 13.4 mg/mL of Akt3 in 20 mM PPES pH 6.8, 15OmM NaCl, 10% glycerol, 10 mM DTT, ImM EDTA, 14%-20% PEG 4000, 50-200 mM CH3COOIvIH4, and 01.M CH3COONa pH 4.5-4.9.
[0076] The mutant (T305D and S472D) Akt3 crystals diffract to approximately 1.95 A resolution using synchrotron radiation source. The crystals belong to the orthorhombic space group P212i21 with unit cell dimensions a=48.288, b=73.031, c=95.372, α = β = γ =90.0. The program HKL2000 was used to index, integrate, and scale the diffraction data.
[0077] The wild type kinase domain Akt3 crystals diffract to approximately 2.5 A resolution using a CuKa X-ray radiation source having the orthorhombic space group P212i21. The Akt3 and mutant (T305D and S472D) Akt3 crystals were solved by molecular replacement using the program EPMR. These crystals diffract to resolutions between 2.5-1.9 A depending on the crystal and X-ray radiation source.
[0078] Co-crystals were obtained by co-crystallization of the compound with the protein at 3-fold molar excess and also by soaking the compound (3.0 mM DMSO) into the Akt3 or the mutant (T305D and S472D) Akt3 crystals.
[0079] The Akt3 co-crystal structures were solved by molecular replacement using the program EPMR with the Akt3 or the mutant (T305D and S472D) Akt3 coordinates as the search model. The coordinates from the molecular replacement solution were subjected to simulated annealing, energy minimization, and individual B-factor refinement using the programs from the CNX suite of programs (Accelrys, San Diego, CA). The refined coordinates were used to calculate the 2Fo-Fc and Fo- Fc omit maps that were visualized in the program O. Additional rounds of refinement of the co-crystal structures were carried out using the programs in the CNX suite.
[0080] It will be appreciated that various crystallization methods including, for example, microcrystallization methods can be utilized to obtain three-dimensional structural information useful in identifying possible therapeutic compounds in the treatment of various disease conditions mediated by Akt3 activity.
Example 6
Akt3 kinase activity assays
[0081] Akt3 kinase activity is measured using either a [γ33P]-ATP-based radiometric assay or an antibody-based, time-resolved fluorescence assay, which measures the level of phosphorylation of a biotin-labeled peptide in the presence of Akt3 kinase. The reagents used in these assays, and the procedures for performing the assays, are described below.
[0082] The following reagents are used in the assays:
Recombinant human Akt3: Histag full length Akt3 protein was expressed in insect cells and purified on Ni affinity resin.
Biotin-peptide substrate: Biotin-Gly-Gly-Gly-Gly-Arg-Pro-Arg-Ala-Ala-Thr-Phe- NH2 (American Peptide Company, Sunnyvale, CA); SEQ ID NO:11
Affinity purified, rabbit anti-phospho-peptide antibody
DELFLA Eu-Nl labeled anti-rabbit antibody (PerkinElmer, Foster City, CA)
DELFIA Enhancement Solution (PerkinElmer, Foster City, CA)
[γ33P]-ATP (PerkinElmer, Foster City, CA)
Assay buffer: (50 mM Tris-HCl (pH 7.5), 10 mM MgCl2, 5 mM MnCl2, 5 mM BGP, 2 mM DTT, and 0.01% BSA)
Time resolved fluorescence assay
[0083] Test compounds are diluted in DMSO to 50 times the final assay concentration. 2 μl of each diluted test compound are then transferred to a 96-well plate and diluted with freshly prepared assay buffer to a final volume of 25 μl. 50 μl assay buffer comprising, 3 nM Akt3 enzyme and 1 μM biotin-peptide substrate, are then added to the diluted test compounds. The reaction is started by the addition of 25 μl of 800 nM ATP in assay buffer, resulting in final concentrations of 1.5 nM enzyme, 0.5 μM biotin-peptide substrate, and 200 nM ATP.
[0084] The reactions are allowed to proceed for 60 minute then stopped by the addition of EDTA to a final concentration of 30 mM. 100 μl of each reaction is transferred to a black 96-well Neutravidin plate (Pierce Biotechnology, Rockford, Illinois). The plates are washed after 1 hour, and anti-phosphopeptide primary antibody is added. After a 1 hour incubation, the plates are again washed, followed by the addition of DELFIA Eu-Nl-labeled anti-rabbit antibody for 1 hour. A final wash is followed by the addition of 100 μl DELFIA Enhancement Solution (PerkinEhner, Foster City, CA), accompanied by 3-5 minutes of shaking. Time resolved fluorescence is then measured using a Wallac Victor 2 instrument (PerkinElmer).
[Y33P] -ATP-based radiometric assay
[0085] Radiometric assays are performed using conditions similar to those described for the time resolved fluorescence assay, except that [γ33P]-ATP is added at the start of each reaction to a final concentration of 5 μCi/ml. The reactions are stopped by the addition of EDTA and 100 μl of each reaction is transferred to 96- well, streptavidin-coated Flashplates (PerkinEhner), to capture the biotin-peptide substrate. After 1 hour, the plates are washed, sealed, and the amount of incorporated 33P is determined using a Wallac MicroBeta Trilux plate counter. [0086] Atomic coordinates of the Akt3 and Akt3 (T305D and S472D) mutant crystals are shown below in Tables 1 and 2 respectively. Atomic coordinates of Akt3 complexed to N-[6-(ammomethyl)-4-chloro-l,3-benzothiazol-2-yl]-5-(2- aminopyrimidin-4-yl)thiophene-2-carboxamide andN-[(lS)-2-amino-l-(2,4- dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide are shown in Tables 3 and 4 respectively. Table 5 shows the atomic coordinates of the Akt3 (T305D and S472D) mutant complexed to N-[(lS)-2-amino-l-(2,4- dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide. In the tables, the abbreviation "INH" refers to an Akt3 binding compound or inhibitor. The abbreviations "TIP", "OH2", and "HOH" refer to a water molecule. The abbreviation "GOL" refers to a glycerol molecule.
Table 1. Atomic Coordinates of Akt3
REMARK refinement resolution: 50.0 - 2.50 A
REMARK starting r= 0.2337 free_r= 0.2783
REMARK final r= 0.2318 free_r= 0.2755
REMARK sg= P2 (1)2 (1)2(1) a= 47.963 b= 72.844 c= 95.316 alpha= 90 beta= 90 gamma= 90
ATOM 1 CB LYS 143 26.381 22.775 20.442 1.00 75.09 A C
ATOM 2 CG LYS 143 27.279 23.639 19.570 1.00 75.71 A C
ATOM 3 CD LYS 143 28.531 24.116 20.301 1.00 76.05 A C
ATOM 4 CE LYS 143 28.198 25.102 21.409 1.00 76.46 A C
ATOM 5 NZ LYS 143 29.426 25.734 21.972 1.00 76.25 A N
ATOM 6 C LYS 143 25.974 20.554 21.498 1.00 75.47 A C
ATOM 7 O LYS 143 25.216 19.953 20.731 1.00 75.51 A O
ATOM 8 N LYS 143 27.791 20.824 19.843 1.00 75.80 A N
ATOM 9 CA LYS 143 27.046 21.494 20.951 1.00 75.55 A C
ATOM 10 N THR 144 25.916 20.422 22.820 1.00 74.84 A N
ATOM 11 CA THR 144 24.924 19.552 23.444 1.00 73.86 A C
ATOM 12 CB THR 144 25.568 18.320 24.095 1.00 74.00 A C
ATOM 13 OGl THR 144 24.535 17.447 24.568 1.00 74.51 A O
ATOM 14 CG2 THR 144 26.446 18.728 25.270 1.00 73.26 A C
ATOM 15 C THR 144 24.139 20.287 24.516 1.00 73.37 A C
ATOM 16 O THR 144 24.576 21.319 25.020 1.00 73.04 A O
ATOM 17 N MET 145 22.980 19.740 24.861 1.00 72.71 A N
ATOM 18 CA MET 145 22.113 20.335 25.866 1.00 73.25 A C
ATOM 19 CB MET 145 21.148 19.275 26.393 1.00 74.37 A C
ATOM 20 CG MET 145 20.024 19.847 27.213 1.00 76.06 A C
ATOM 21 SD MET 145 19.155 21.114 26.269 1.00 79.68 A S
ATOM 22 CE MET 145 19.826 22.636 27.011 1.00 77.67 A C
ATOM 23 C MET 145 22.885 20.967 27.032 1.00 72.98 A C
ATOM 24 O MET 145 22.531 22.045 27.515 1.00 71.58 A O
ATOM 25 N ASN 146 23.941 20.293 27.478 1.00 72.72 A N
ATOM 26 CA ASN 146 24.762 20.781 28.585 1.00 72.34 A C
ATOM 27 CB ASN 146 25.693 19.665 29.080 1.00 73.57 A C
ATOM 28 CG ASN 146 24.934 18.474 29.649 1.00 73.70 A C
ATOM 29 ODl ASN 146 24.354 18.552 30.735 1.00 73.91 A O
ATOM 30 ND2 ASN 146 24.931 17.365 28.912 1.00 73.02 A N
ATOM 31 C ASN 146 25.599 22.000 28.195 1.00 71.39 A C
ATOM 32 O ASN 146 26.378 22.508 29.004 1.00 71.31 A O
ATOM 33 N ASP 147 25.435 22.466 26.959 1.00 69.97 A N
ATOM 34 CA ASP 147 26.189 23.619 26.465 1.00 68.02 A C
ATOM 35 CB ASP 147 26.523 23.434 24.983 1.00 69.06 A C
ATOM 36 CG ASP 147 27.514 22.309 24.740 1.00 70.51 A C
ATOM 37 ODl ASP 147 27.176 21.134 25.006 1.00 69.95 A O
ATOM 38 OD2 ASP 147 28.637 22.606 24.280 1.00 70.26 A O ATOM 39 C ASP 147 25.450 24.942 26.644 1.00 66.18 A C
ATOM 40 O ASP 147 26.026 26.019 26.459 1.00 66.66 A O
ATOM 41 N PHE 148 24.176 24.860 27.009 1.00 62.59 A N
ATOM 42 CA PHE 148 23.372 26.059 27.187 1.00 59.30 A C
ATOM 43 CB PHE 148 22.287 26.119 26.114 1.00 59.41 A C
ATOM 44 CG PHE 148 22.736 25.636 24.770 1.00 58.08 A C
ATOM 45 CDl PHE 148 23.427 26.471 23.911 1.00 58.47 A C
ATOM 46 CD2 PHE 148 22.466 24.338 24.367 1.00 58.25 A C
ATOM 47 CEl PHE 148 23.838 26.022 22.676 1.00 56.95 A C
ATOM 48 CE2 PHE 148 22.877 23.882 23.132 1.00 57.20 A C
ATOM 49 CZ PHE 148 23.563 24.726 22.286 1.00 57.44 A C
ATOM 50 C PHE 148 22.689 26.104 28.547 1.00 56.97 A C
ATOM 51 O PHE 148 22.426 25.071 29.166 1.00 56.30 A O
ATOM 52 N ASP 149 22.405 27.317 29.004 1.00 53.25 A N
ATOM 53 CA ASP 149 21.703 27.502 30.256 1.00 49.36 A C
ATOM 54 CB ASP 149 22.110 28.813 30.932 1.00 49.13 A C
ATOM 55 CG ASP 149 23.508 28.768 31.485 1.00 49.76 A C
ATOM 56 ODl ASP 149 23.913 27.674 31.930 1.00 50.76 A O
ATOM 57 OD2 ASP 149 24.192 29.818 31.491 1.00 51.11 A O
ATOM 58 C ASP 149 20.227 27.562 29.889 1.00 47.34 A C
ATOM 59 O ASP 149 19.848 28.231 28.926 1.00 47.63 A O
ATOM 60 N TYR 150 19.402 26.846 30.640 1.00 44.82 A N
ATOM 61 CA TYR 150 17.969 26.837 30.398 1.00 43.28 A C
ATOM 62 CB TYR 150 17.381 25.483 30.794 1.00 43.49 A C
ATOM 63 CG TYR 150 15.875 25.470 30.908 1.00 44.34 A C
ATOM 64 CDl TYR 150 15.076 26.038 29.927 1.00 43.66 A C
ATOM 65 CEl TYR 150 13.703 26.008 30.032 1.00 43.74 A C
ATOM 66 CD2 TYR 150 15.253 24.871 31.993 1.00 44.22 A C
ATOM 67 CE2 TYR 150 13.885 24.834 32.101 1.00 44.37 A C
ATOM 68 CZ TYR 150 13.116 25.402 31.122 1.00 43.63 A C
ATOM 69 OH TYR 150 11.751 25.353 31.236 1.00 43.95 A O
ATOM 70 C TYR 150 17.361 27.959 31.224 1.00 41.45 A C
ATOM 71 O TYR 150 17.156 27.824 32.424 1.00 41.87 A O
ATOM 72 N LEU 151 17.082' 29.076 30.567 1.00 40.48 A N
ATOM 73 CA LEU 151 16.534 30.242 31.240 1.00 37.28 A C
ATOM 74 CB LEU 151 16.906 31.500 30.458 1.00 35.33 A C
ATOM 75 CG LEU 151 18.342 31.965 30.689 1.00 36.08 A C
ATOM 76 CDl LEU 151 19.177 30.798 31.143 1.00 36.10 A C
ATOM 77 CD2 LEU 151 18.900 32.590 29.430 1.00 34.68 A C
ATOM 78 C LEU 151 15.038 30.221 31.501 1.00 36.68 A C
ATOM 79 O LEU 151 14.609 30.473 32.620 1.00 36.72 A O
ATOM 80 N LYS 152 14.241 29.926 30.481 1.00 36.58 A N
ATOM 81 CA LYS 152 12.797 29.910 30.659 1.00 37.38 A C
ATOM 82 CB LYS 152 12.296 31.352 30.804 1.00 37.79 A C
ATOM 83 CG LYS 152 10.786 31.519 30.888 1.00 37.65 A C
ATOM 84 CD LYS 152 10.438 32.856 31.532 1.00 39.21 A C
ATOM 85 CE LYS 152 8.985 33.235 31.282 1.00 42.58 A C
ATOM 86 NZ LYS 152 8.706 33.535 29.826 1.00 44.45 A N
ATOM 87 C LYS 152 12.054 29.208 29.531 1.00 37.73 A C
ATOM 88 O LYS 152 12.549 29.121 28.411 1.00 39.41 A O
ATOM 89 N LEU 153 10.868 28.695 29.836 1.00 37.67 A N
ATOM 90 CA LEU 153 10.057 28.027 28.832 1.00 38.99 A C
ATOM 91 CB LEU 153 9.054 27.081 29.499 1.00 38.62 A C
ATOM 92 CG LEU 153 8.452 25.962 28.633 1.00 40.48 A C
ATOM 93 CDl LEU 153 7.371 26.495 27.703 1.00 40.60 A C
ATOM 94 CD2 LEU 153 9.573 25.309 27.832 1.00 38.04 A C
ATOM 95 C LEU 153 9.325 29.133 28.072 1.00 40.61 A C
ATOM 96 O LEU 153 8.632 29.952 28.677 1.00 41.99 A O
ATOM 97 N LEU 154 9.503 29.171 26.753 1.00 41.54 A N
ATOM 98 CA LEU 154 8.869 30.193 25.923 1.00 42.57 A C
ATOM 99 CB LEU 154 9.780 30.543 24.748 1.00 39.59 A C
ATOM 100 CG LEU 154 11.044 31.260 25.200 1.00 38.35 A C
ATOM 101 CDl LEU 154 11.915 31.602 24.006 1.00 34.56 A C
ATOM 102 CD2 LEU 154 10.635 32.518 25.951 1.00 36.65 A C
ATOM 103 C LEU 154 7.495 29.774 25.411 1.00 44.08 A C
ATOM 104 O LEU 154 6.622 30.610 25.184 1.00 42.08 A O
ATOM 105 N GLY 155 7.310 28.473 25.238 1.00 47.43 A N
ATOM 106 CA GLY 155 6.036 27.971 24.771 1.00 51.90 A C
ATOM 107 C GLY 155 6.115 26.480 24.556 1.00 56.01 A C
ATOM 108 O GLY 155 7.202 25.903 24.551 1.00 55.94 A O
ATOM 109 N LYS 156 4.959 25.851 24.382 1.00 60.38 A N
ATOM 110 CA LYS 156 4.902 24.414 24.153 1.00 64.09 A C
ATOM 111 CB LYS 156 5.272 23.663 25.439 1.00 6B 30 A C ATOM 112 CG LYS 156 4.439 24.034 26.658 1.00 67.11 A C
ATOM 113 CD LYS 156 3.182 23.179 26.768 1.00 68.73 A C
ATOM 114 CE LYS 156 3.527 21.731 27.084 1.00 69.51 A C
ATOM 115 NZ LYS 156 4.259 21.595 28.380 1.00 70.07 A N
ATOM 116 C LYS 156 3.523 23.984 23.660 1.00 66.49 A C
ATOM 117 O LYS 156 2.506 24.610 23.983 1.00 67.03 A O
ATOM 118 N GLY 157 3.502 22.924 22.858 1.00 67.65 A N
ATOM 119 CA GLY 157 2.250 22.412 22.339 1.00 69.10 A C
ATOM 120 C GLY 157 2.209 20.910 22.518 1.00 70.48 A C
ATOM 121 O GLY 157 2.330 20.404 23.637 1.00 70.43 A O
ATOM 122 N THR 158 2.038 20.195 21.412 1.00 71.47 A N
ATOM 123 CA THR 158 1.997 18.738 21.436 1.00 72.63 A C
ATOM 124 CB THR 158 0.711 18.214 20.767 1.00 72.58 A C
ATOM 125 OGl THR 158 0.598 18.773 19.454 1.00 72.90 A O
ATOM 126 CG2 THR 158 -0.518 18.605 21.588 1.00 72.37 A C
ATOM 127 C THR 158 3.222 18.221 20.683 1.00 72.64 A C
ATOM 128 O THR 158 3.753 17.147 20.978 1.00 72.60 A O
ATOM 129 N PHE 159 3.667 19.018 19.719 1.00 72.63 A N
ATOM 130 CA PHE 159 4.828 18.701 18.898 1.00 72.72 A C
ATOM 131 CB PHE 159 4.711 19.435 17.558 1.00 75.82 A C
ATOM 132 CG PHE 159 4.162 20.833 17.678 1.00 79.15 A C
ATOM 133 CDl PHE 159 3.503 21.427 16.610 1.00 80.94 A C
ATOM 134 CD2 PHE 159 4.287 21.547 18.866 1.00 81.04 A C
ATOM 135 CEl PHE 159 2.972 22.707 16.724 1.00 82.06 A C
ATOM 136 CE2 PHE 159 3.761 22.828 18.989 1.00 81.91 A C
ATOM 137 CZ PHE 159 3.101 23.408 17.916 1.00 82.48 A C
ATOM 138 C PHE 159 6.135 19.075 19.596 1.00 70.72 A C
ATOM 139 O PHE 159 7.214 18.957 19.020 1.00 71.31 A O
ATOM 140 N GLY 160 6.031 19.517 20.843 1.00 68.52 A N
ATOM 141 CA GLY 160 7.214 19.902 21.592 1.00 65.14 A C
ATOM 142 C GLY 160 7.085 21.329 22.084 1.00 63.23 A C
ATOM 143 O GLY 160 5.971 21.834 22.257 1.00 63.15 A O
ATOM 144 N LYS 161 8.216 21.992 •22.306 1.00 60.19 A N
ATOM 145 CA LYS 161 8.187 23.366 22.782 1.00 56.69 A C
ATOM 146 CB LYS 161 7.915 23.396 24.287 1.00 57.36 A C
ATOM 147 CG LYS 161 9.132 23.123 25.155 1.00 57.78 A C
ATOM 148 CD LYS 161 9.783 21.790 24.834 1.00 56.66 A C
ATOM 149 CE LYS 161 10.895 21.485 25.823 1.00 55.66 A C
ATOM 150 NZ LYS 161 10.382 21.477 27.224 1.00 53.50 A N
ATOM 151 C LYS 161 9.470 24.128 22.491 1.00 53.96 A C
ATOM 152 O LYS 161 10.418 23.597 21.913 1.00 54.04 A O
ATOM 153 N VAL 162 9.486 25.384 22.915 1.00 49.75 A N
ATOM 154 CA VAL 162 10.626 26.258 22.712 1.00 46.29 A C
ATOM 155 CB VAL 162 10.245 27.433 21.795 1.00 46.41 A C
ATOM 156 CGl VAL 162 11.489 •28.131 21.297 1.00 45.74 A C
ATOM 157 CG2 VAL 162 9.399 26.933 20.639 1.00 45.81 A C
ATOM 158 C VAL 162 11.053 26.816 24.065 1.00 44.21 A C
ATOM 159 O VAL 162 10.216 27.072 24.932 1.00 43.07 A O
ATOM 160 N ILE 163 12.352 27.011 24.245 1.00 41.32 A N
ATOM 161 CA ILE 163 12.848 27.542 25.500 1.00 39.99 A C
ATOM 162 CB ILE 163 13.392 26.417 26.387 1.00 39.64 A C
ATOM 163 CG2 ILE 163 12.311 25.375 26.623 1.00 40.53 A C
ATOM 164 CGl ILE 163 14.601 25.767 25.710 1.00 40.10 A C
ATOM 165 CDl ILE 163 15.013 24.453 26.332 1.00 35.49 A C
ATOM 166 C ILE 163 13.957 28.558 25.298 1.00 38.92 A C
ATOM 1S7 O ILE 163 14.784 28.416 24.402 1.00 40.80 A O
ATOM 168 N LEU 164 13.965 29.594 26.128 1.00 36.27 A N
ATOM 169 CA LEU 164 15.005 30.598 26.049 1.00 33.80 A C
ATOM 170 CB LEU 164 14.673 31.792 26.940 1.00 31.84 A C
ATOM 171 CG LEU 164 15.783 32.832 27.064 1.00 30.26 A C
ATOM 172 CDl LEU 164 16.339 33.158 25.682 1.00 32.51 A C
ATOM 173 CD2 LEU 164 15.242 34.078 27.739 1.00 30.37 A C
ATOM 174 C LEU 164 16.236 29.879 26.562 1.00 34.60 A C
ATOM 175 O LEU 164 16.140 29.072 27.482 1.00 36.19 A O
ATOM 176 N VAL 165 17.390 30.172 25.974 1.00 34.96 A N
ATOM 177 CA VAL 165 18.621 29.506 26.360 1.00 35.33 A C
ATOM 178 CB VAL 165 18.840 28.263 25.461 1.00 34.00 A C
ATOM 179 CGl VAL 165 20.068 28.449 24.594 1.00 33.08 A C
ATOM 180 CG2 VAL 165 18.941 27.021 26.309 1.00 32.48 A C
ATOM 181 C VAL 165 19.830 30.433 26.258 1.00 37.26 A C
ATOM 182 O VAL 165 19.774 31.471 25.608 1.00 38.29 A O
ATOM 183 N ARG 166 20.914 30.071 26.929 1.00 39.87 A N
ATOM 184 CA ARG 166 22.135 30.862 26.874 1.00 43.94 A C ATOM 185 CB ARG 166 22.380 31.624 28.177 1.00 42.14 A C
ATOM 186 CG ARG 166 23.714 32.370 28.160 1.00 41.39 A C
ATOM 187 CD ARG 166 24.190 32.752 29.547 1.00 38.45 A C
ATOM 188 NE ARG 166 23.472 33.904 30.077 1.00 40.55 A N
ATOM 189 CZ ARG 166 22.741 33.890 31.189 1.00 37.38 A C
ATOM 190 NHl ARG 166 22.626 32.769 31.898 1.00 36.03 A N
ATOM 191 NH2 ARG 166 22.133 35.003 31.592 1.00 34.03 A N
ATOM 192 C ARG 166 23.297 29.912 26.650 1.00 46.66 A C
ATOM 193 O ARG 166 23.526 29.011 27.453 1.00 48.85 A O
ATOM 194 N GLU 167 24.032 30.108 25.563 1.00 49.96 A N
ATOM 195 CA GLU 167 25.164 29.241 25.272 1.00 53.17 A C
ATOM 196 CB GLU 167 25.662 29.467 23.843 1.00 54.02 A C
ATOM 197 CG GLU 167 26.508 28.318 23.309 1.00 56.88 A C
ATOM 198 CD GLU 167 27.380 28.723 22.130 1.00 59.00 A C
ATOM 199 OEl GLU 167 26.839 29.111 21.068 1.00 57.74 A O
ATOM 200 OE2 GLU 167 28.619 28.652 22.278 1.00 60.79 A O
ATOM 201 C GLU 167 26.272 29.562 26.268 1.00 54.17 A C
ATOM 202 O GLU 167 26.748 30.697 26.336 1.00 55.02 A O
ATOM 203 N LYS 168 26.664 28.555 27.044 1.00 55.86 A N
ATOM 204 CA LYS 168 27.703 28.687 28.066 1.00 57.48 A C
ATOM 205 CB LYS 168 28.179 27.293 28.486 1.00 59.12 A C
ATOM 206 CG LYS 168 27.249 26.544 29.427 1.00 61.43 A C
ATOM 207 CD LYS 168 27.367 27.097 30.836 1.00 63.94 A C
ATOM 208 CE LYS 168 26.729 26.175 31.864 1.00 65.12 A C
ATOM 209 NZ LYS 168 26.898 26.714 33.253 1.00 65.47 A N
ATOM 210 C LYS 168 28.913 29.524 27.645 1.00 57.63 A C
ATOM 211 O LYS 168 29.182 30.586 28.218 1.00 57.02 A O
ATOM 212 N ALA 169 29.634 29.029 26.641 1.00 57.60 A N
ATOM 213 CA ALA 169 30.840 29.670 26.120 1.00 57.29 A C
ATOM 214 CB ALA 169 31.360 28.873 24.922 1.00 55.94 A C
ATOM 215 C ALA 169 30.682 31.138 25.731 1.00 57.37 A C
ATOM 216 O ALA 169 31.244 32.032 26.373 1.00 57.31 A O
ATOM 217 N SER 170 29.920 31.369 24.667 1.00 57.39 A N
ATOM 218 CA SER 170 29.683 32.706 24.140 1.00 56.37 A C
ATOM 219 CB SER 170 29.008 32.614 22.774 1.00 57.12 A C
ATOM 220 OG SER 170 27.642 32.252 22.910 1.00 57.67 A O
ATOM 221 C SER 170 28.820 33.583 25.033 1.00 55.72 A C
ATOM 222 O SER 170 29.001 34.804 25.071 1.00 55.16 A O
ATOM 223 N GLY 171 27.868 32.967 25.729 1.00 53.79 A N
ATOM 224 CA GLY 171 26.979 33.733 26.582 1.00 52.36 A C
ATOM 225 C GLY 171 25.924 34.460 25.761 1.00 51.71 A C
ATOM 226 O GLY 171 25.269 35.378 26.249 1.00 50.54 A O
ATOM 227 N LYS 172 25.767 34.056 24.503 1.00 50.35 A N
ATOM 228 CA LYS 172 24.774 34.661 23.619 1.00 48.35 A C
ATOM 229 CB LYS 172 25.220 34.544 22.154 1.00 50.59 A C
ATOM 230 CG LYS 172 26.145 35.667 21.680 1.00 52.08 A C
ATOM 231 CD LYS 172 26.705 35.394 20.282 1.00 54.46 A C
ATOM 232 CE LYS 172 25.620 34.914 19.319 1.00 56.17 A C
ATOM 233 NZ LYS 172 24.427 35.817 19.248 1.00 57.23 A N
ATOM 234 C LYS 172 23.431 33.962 23.809 1.00 46.10 A C
ATOM 235 O LYS 172 23.378 32.760 24.074 1.00 44.02 A O
ATOM 236 N TYR 173 22.344 34.711 23.664 1.00 44.35 A N
ATOM 237 CA TYR 173 21.025 34.125 23.844 1.00 42.92 A C
ATOM 238 CB TYR 173 20.061 35.170 24.411 1.00 41.47 A C
ATOM 239 CG TYR 173 20.558 35.710 25.726 1.00 40.11 A C
ATOM 240 CDl TYR 173 21.317 36.873 25.776 1.00 39.95 A C
ATOM 241 CEl TYR 173 21.879 37.311 26.962 1.00 42.10 A C
ATOM 242 CD2 TYR 173 20.365 34.999 26.906 1.00 40.45 A C
ATOM 243 CE2 TYR 173 20.923 35.424 28.097 1.00 39.71 A C
ATOM 244 CZ TYR 173 21.681 36.580 28.122 1.00 42.03 A C
ATOM 245 OH TYR 173 22.257 37.008 29.299 1.00 42.25 A O
ATOM 246 C TYR 173 20.464 33.491 22.584 1.00 42.48 A C
ATOM 247 O TYR 173 20.758 33.924 21.472 1.00 41.47 A O
ATOM 248 N TYR 174 19.666 32.442 22.779 1.00 42.96 A N
ATOM 249 CA TYR 174 19.053 31.698 21.681 1.00 42.52 A C
ATOM 250 CB TYR 174 20.004 30.594 21.191 1.00 41.07 A C
ATOM 251 CG TYR 174 21.267 31.094 20.544 1.00 41.94 A C
ATOM 252 CDl TYR 174 21.218 31.831 19.373 1.00 42.55 A C
ATOM 253 CEl TYR 174 22.369 32.294 18.769 1.00 43.38 A C
ATOM 254 CD2 TYR 174 22.506 30.829 21.102 1.00 41.50 A C
ATOM 255 CE2 TYR 174 23.667 31.287 20.509 1.00 43.67 A C
ATOM 256 CZ TYR 174 23.593 32.021 19.337 1.00 45.03 A C
ATOM 257 OH TYR 174 24.743 32.481 18.720 1.00 44.59 A O ATOM 258 C TYR 174 17.746 31.038 22.110 .00 42.04 A C
ATOM 259 O TYR 174 17.516 30.799 23.289 .00 42.04 A O
ATOM 260 N ALA 175 16.894 30.745 21.138 .00 41.28 A N
ATOM 261 CA ALA 175 15.648 30.060 21.411 ,00 41.15 A C
ATOM 262 CB AIA 175 14.502 30.762 20.727 ,00 39.83 A C
ATOM 263 C ALA 175 15.845 28.671 20.817 ,00 42.15 A C
ATOM 264 O ALA 175 16.032 28.537 19.612 .00 42.09 A O
ATOM 265 N MET 176 15.820 27.641 21.658 .00 43.45 A N
ATOM 266 CA MET 176 16.010 26.271 21.186 .00 45.08 A C
ATOM 267 CB MET 176 16.855 25.488 22.194 1.00 43.05 A C
ATOM 268 CG MET 176 17.186 24.067 21.763 00 40.58 A C
ATOM 269 SD MET 176 17.927 23.077 23.096 00 41.30 A S
ATOM 270 CE MET 176 19.658 23.626 23.012 00 34.42 A C
ATOM 271 C MET 176 14.689 25.538 20.944 00 47.36 A C
ATOM 272 O MET 176 13.903 25.337 21.866 00 48.22 A O
ATOM 273 N LYS 177 14.441 25.152 19.696 1.00 50.70 A N
ATOM 274 CA LYS 177 13.215 24.437 19.357 1.00 54.76 A C
ATOM 275 CB LYS 177 12.914 24.560 17.861 1.00 57.66 A C
ATOM 276 CG LYS 111 11.533 25.138 17.501 1.00 61.19 A C
ATOM 277 CD LYS 177 10.392 24.119 17.588 1.00 63.13 A C
ATOM 278 CE LYS 177 10.054 23.730 19.028 1.00 64.26 A C
ATOM 279 NZ LYS 177 8.873 22.809 19.108 1.00 64.30 A N
ATOM 280 C LYS 177 13.452 22.982 19.707 1.00 57.86 A C
ATOM 281 0 LYS 177 14.455 22.394 19.293 1.00 57.60 A O
ATOM 282 N ILE 178 12.543 22.404 20.480 1.00 60.28 A N
ATOM 283 CA ILE 178 12.678 21.011 20.876 1 00 63.05 A C
ATOM 284 CB ILE 178 12.991 20.897 22.375 1 00 62.85 A C
ATOM 285 CG2 ILE 178 12.894 19.447 22.819 1 00 62.35 A C
ATOM 286 CGl ILE 178 14.385 21.475 22.647 1 00 63.52 A C
ATOM 287 CDl ILE 178 14.823 21.402 24.096 1 00 63.23 A C
ATOM 288 C ILE 178 11.425 20.215 20.556 1 00 64.95 A C
ATOM 289 O ILE 178 10.514 20.107 21.380 1 00 64.67 A O
ATOM 290 N LEU 179 11.392 19.664 19.345 1 00 67.97 A N
ATOM 291 CA LEU 179 10.262 18.866 18.876 1 00 70.86 A C
ATOM 292 CB LEU 179 10.221 18.832 17.345 1 00 70.28 A C
ATOM 293 CG LEU 179 9.794 20.115 16.632 1.00 70.33 A C
ATOM 294 CDl LEU 179 8.414 20.540 17.131 1.00 70.53 A C
ATOM 295 CD2 LEU 179 10.814 21.206 16.880 1.00 69.83 A C
ATOM 296 C LEU 179 10.315 17.439 19.405 1.00 72.70 A C
ATOM 297 O LEU 179 11.381 16.809 19.433 1.00 72.32 A O
ATOM 298 N LYS 180 9.152 16.942 19.820 1.00 75.07 A N
ATOM 299 CA LYS 180 9.032 15.592 20.357 1.00 77.95 A C
ATOM 300 CB LYS 180 7.584 15.105 20.235 1.00 78.26 A C
ATOM 301 CG LYS 180 6.665 15.685 21.298 78.17 A C
ATOM 302 CD LYS 180 7.193 15.317 22.671 77.82 A C
ATOM 303 CE LYS 180 6.393 15.963 23.776 78.15 A C
ATOM 304 NZ LYS 180 6.944 15.565 25.101 78.53 A N
ATOM 305 C LYS 180 9.972 14.622 19.655 79.62 A C
ATOM 306 O LYS 180 9.808 14.342 18.464 1.00 79.30 A O
ATOM 307 N LYS 181 10.955 14.121 20.405 .00 81.26 A N
ATOM 308 CA LYS 181 11.941 13.179 19.885 .00 83.16 A C
ATOM 309 CB LYS 181 11.785 11.814 20.561 .00 82.90 A C
ATOM 310 CG LYS 181 11.778 11.860 22.082 .00 82.19 A C
ATOM 311 CD LYS 181 11.590 10.469 22.661 .00 80.98 A C
ATOM 312 CE LYS 181 10.467 9.730 21.951 .00 80.17 A C
ATOM 313 NZ LYS 181 9.187 10.492 21.976 .00 79.89 A N
ATOM 314 C LYS 181 11.771 13.021 18.381 .00 85.01 A C
ATOM 315 O LYS 181 12.559 13.557 17.601 .00 86.68 A O
ATOM 316 N GLU 182 10.738 12.286 17.977 .00 85.88 A N
ATOM 317 CA GLU 182 10.462 12.067 16.562 .00 85.91 A C
ATOM 318 CB GLU 182 11.386 10.974 16.006 .00 86.13 A C
ATOM 319 CG GLU 182 12.873 11.360 15.954 .00 85.40 A C
ATOM 320 CD GLU 182 13.584 11.239 17.298 .00 85.38 A C
ATOM 321 OEl GLU 182 14.701 11.790 17.427 .00 84.08 A O
ATOM 322 OE2 GLU 182 13.035 10.590 18.219 .00 85.22 A O
ATOM 323 C GLU 182 8.999 11.686 16.325 .00 86.24 A C
ATOM 324 O GLU 182 8.702 10.595 15.839 .00 86.43 A O
ATOM 325 N VAL 183 8.087 12.592 16.672 1.00 86.24 A N
ATOM 326 CA VAL 183 6.659 12.345 16.491 1.00 86.25 A C
ATOM 327 CB VAL 183 5.850 12.738 17.739 1.00 86.37 A C
ATOM 328 CGl VAL 183 5.798 14.255 17.870 1.00 86.10 A C
ATOM 329 CG2 VAL 183 4.449 12.153 17.646 1.00 85.60 A C
ATOM 330 C VAL 183 6.124 13.144 15.307 1.00 86.44 A C ATOM 331 O VAL 183 4.916 13.168 15.051 1.00 86.50 A O
ATOM 332 N ILE 184 7.033 13.809 14.600 1.00 86.24 A N
ATOM 333 CA ILE 184 6.677 14.599 13.426 1.00 85.52 A C
ATOM 334 CB ILE 184 7.892 15.368 12.872 1.00 84.95 A C
ATOM 335 CG2 ILE 184 7.485 16.187 11.669 1.00 83.69 A C
ATOM 336 CGl ILE 184 8.495 16.253 13.961 1.00 84.41 A C
ATOM 337 CDl ILE 184 9.164 15.478 15.078 1.00 85.19 A C
ATOM 338 C ILE 184 6.242 13.594 12.377 1.00 85.64 A C
ATOM 339 O ILE 184 5.520 13.916 11.434 1.00 85.81 A O
ATOM 340 N ILE 185 6.706 12.365 12.562 1.00 85.79 A N
ATOM 341 CA ILE 185 6.398 11.274 11.660 1.00 85.53 A C
ATOM 342 CB ILE 185 7.072 9.972 12.134 1.00 85.19 A C
ATOM 343 CG2 ILE 185 6.660 9.670 13.568 1.00 84.03 A C
ATOM 344 CGl ILE 185 6.717 8.827 11.183 1.00 86.13 A C
ATOM 345 CDl ILE 185 7.458 7.530 11.469 1.00 86.89 A C
ATOM 346 C ILE 185 4.893 11.075 11.592 1.00 85.68 A C
ATOM 347 O ILE 185 4.338 10.863 10.514 1.00 86.21 A O
ATOM 348 N ALA 186 4.235 11.156 12.745 1.00 85.53 A N
ATOM 349 CA ALA 186 2.790 10.986 12.812 1.00 85.64 A C
ATOM 350 CB ALA 186 2.365 10.730 14.252 1.00 85.62 A C
ATOM 351 C ALA 186 2.080 12.220 12.256 1.00 85.64 A C
ATOM 352 O AIA 186 1.027 12.624 12.746 1.00 84.75 A O
ATOM 353 K LYS 187 2.673 12.809 11.223 1.00 86.48 A N
ATOM 354 CA LYS 187 2.121 13.996 10.576 1.00 87.68 A C
ATOM 355 CB LYS 187 2.472 15.249 11.383 1.00 88.49 A C
ATOM 356 CG LYS 187 1.791 16.521 10.896 1.00 89.09 A C
ATOM 357 CD LYS 187 0.282 16.401 11.017 1.00 90.54 A C
ATOM 358 CE LYS 187 -0.128 16.022 12.440 1.00 91.36 A C
ATOM 359 NZ LYS 187 -1.598 15.803 12.574 1.00 91.90 A N
ATOM 360 C LYS 187 2.688 14.123 9.161 1.00 87.84 A C
ATOM 361 O LYS 187 1.985 14.531 8.234 1.00 87.74 A O
ATOM 362 N ASP 188 3.965 13.768 9.016 1.00 87.85 A N
ATOM 363 CA ASP 188 4.677 13.820 7.739 1.00 87.58 A C
ATOM 364 CB ASP 188 3.701 13.684 6.569 1.00 88.17 A C
ATOM 365 CG ASP 188 2.938 12.379 6.597 1.00 88.47 A C
ATOM 366 ODl ASP 188 2.180 12.118 5.639 1.00 88.73 A O
ATOM 367 OD2 ASP 188 3.096 11.616 7.573 1.00 88.55 A O
ATOM 368 C ASP 188 5.467 15.116 7.588 1.00 86.89 A C
ATOM 369 O ASP 188 5.804 15.529 6.476 1.00 86.61 A O
ATOM 370 N GLU 189 5.766 15.754 8.711 1.00 85.82 A N
ATOM 371 CA GLU 189 6.511 17.000 8.674 1.00 85.05 A C
ATOM .372 CB GLU 189 6.157 17.859 9.894 1.00 86.30 A C
ATOM 373 CG GLU 189 6.312 19.352 9.658 1.00 88.32 A C
ATOM 374 CD GLU 189 5.331 19.880 8.618 1.00 89.57 A C
ATOM 375 OEl GLU 189 5.464 21.058 8.218 1.00 90.47 A O
ATOM 376 OE2 GLU 189 4.427 19.118 8.205 1.00 88.73 A O
ATOM 377 C GLU 189 8.013 16.717 8.637 1.00 83.17 A C
ATOM 378 O GLU 189 8.819 17.626 8.432 1.00 83.46 A O
ATOM 379 N VAL 190 8.378 15.451 8.827 1.00 80.22 A N
ATOM 380 CA VAL 190 9.779 15.030 8.812 1.00 77.01 A C
ATOM 381 CB VAL 190 9.892 13.501 8.832 1.00 77.04 A C
ATOM 382 CGl VAL 190 9.036 12.934 9.949 1.00 76.12 A C
ATOM 383 CG2 VAL 190 9.464 12.937 7.493 1.00 76.24 A C
ATOM 384 C VAL 190 10.479 15.539 7.555 1.00 75.22 A C
ATOM 385 O VAL 190 11.646 15.928 7.586 1.00 74.73 A O
ATOM 386 N ALA 191 9.758 15.522 6.443 1.00 73.64 A N
ATOM 387 CA ALA 191 10.303 16.000 5.187 1.00 72.02 A C
ATOM 388 CB ALA 191 9.357 15.660 4.047 1.00 72.89 A C
ATOM 389 C ALA 191 10.468 17.507 5.297 1.00 70.64 A C
ATOM 390 O ALA 191 11.580 18.031 5.251 1.00 70.50 A O
ATOM 391 N HIS 192 9.347 18.196 5.462 1.00 68.73 A N
ATOM 392 CA HIS 192 9.345 19.643 5.574 1.00 67.77 A C
ATOM 393 CB HIS 192 7.922 20.147 5.812 1.00 70.73 A C
ATOM 394 CG HIS 192 7.524 21.277 4.915 1.00 73.54 A C
ATOM 395 CD2 HIS 192 8.205 21.924 3.939 1.00 74.83 A C
ATOM 396 NDl HIS 192 6.267 21.845 4.945 1.00 75.49 A N
ATOM 397 CEl HIS 192 6.190 22.790 4.024 1.00 75.68 A C
ATOM 398 NE2 HIS 192 7.353 22.857 3.400 1.00 76.07 A N
ATOM 399 C HIS 192 10.247 20.140 6.694 1.00 65.41 A C
ATOM 400 O HIS 192 10.882 21.187 6.566 1.00 66.07 A O
ATOM 401 N THR 193 10.307 19.395 7.792 1.00 61.72 A N
ATOM 402 CA THR 193 11.134 19.802 8.923 1.00 58.95 A C
ATOM 403 CB THR 193 10.912 18.896 10.137 1.00 58.02 A C ATOM 404 OGl THR 193 9.515 18.829 10.435 1.00 57.25 A O ATOM 405 CG2 THR 193 11.638 19.458 11.346 1.00 57.75 A C ATOM 406 C THR 193 12.625 19.820 8.599 1.00 57.76 A C ATOM 407 O THR 193 13.297 20.825 8.806 1.00 57.32 A O ATOM 408 N LEU 194 13.144 18.707 8.096 1.00 57.83 A N ATOM 409 CA LEU 194 14.559 18.629 7.745 1.00 57.76 A C ATOM 410 CB LEU 194 14.926 17.196 7.365 1.00 57.Sl A C ATOM 411 CG LEU 194 14.713 16.178 8.488 1.00 56.12 A C ATOM 412 CDl LEU 194 15.105 14.795 8.000 1.00 56.13 A C ATOM 413 CD2 LEU 194 15.533 16.575 9.708 1.00 55.10 A C ATOM 414 C LEU 194 14.857 19.569 6.585 1.00 58.64 A C ATOM 415 O LEU 194 15.971 20.071 6.437 1.00 58.08 A O ATOM 416 N THR 195 13.845 19.807 5.764 1.00 59.96 A N ATOM 417 CA THR 195 13.983 20.696 4.624 1.00 60.55 A C ATOM 418 CB THR 195 12.772 20.577 3.689 1.00 60.93 A C ATOM 419 OGl THR 195 12.653 19.223 3.234 1.00 60.65 A O ATOM 420 CG2 THR 195 12.926 21.511 2.495 1.00 59.38 A C ATOM 421 C THR 195 14.088 22.144 5.093 1.00 61.49 A C ATOM 422 O THR 195 15.118 22.794 4.920 1.00 61.74 A O ATOM 423 N GLU 196 13.014 22.645 5.691 1.00 61.82 A N ATOM 424 CA GLU 196 12.998 24.019 6.162 1.00 62.20 A C ATOM 425 CB GLU 196 11.688 24.307 6..906 1.00 63.65 A C ATOM 426 CG GLU 195 10.417 24.229 6. ,036 1.00 65.87 A C ATOM 427 CD GLU 196 10.361 25.290 4..928 1.00 67.35 A C ATOM 428 OEl GLU 196 10.492 26.499 5..235 1.00 66 ..3300 A O ATOM 429 OE2 GLU 196 10.174 24.914 3. ,748 1.00 66..9900 A O ATOM 430 C C G GLLUU 196 14.202 24.304 7.061 1.00 61.89 A C ATOM 431 O O G GLLUU 196 14.669 25.441 7.144 1.00 61.61 A O ATOM 432 N N S SEERR 197 14.713 23.273 7.726 1.00 61.12 A N ATOM 433 C CAA S SEERR 197 15.867 23.451 8.602 1.00 61.92 A C ATOM 434 C CBB S SEERR 197 16.149 22.166 9.384 1.00 62.66 A C ATOM 435 OG SER 197 16.447 21.100 8.505 1.00 65.47 A O ATOM 4 43366 C SER 197 17.094 23.837 7.780 1.00 61.63 A C ATOM 4 43377 O SER 197 17.814 24.779 8.117 1.00 61.23 A O ATOM 4 43388 N ARG 198 17.328 23.102 6.701 1.00 61.10 A N ATOM 4 43399 CA ARG 198 18.454 23.377 5.821 1.00 61.96 A C ATOM 440 CB ARG 198 18.334 22.535 4.548 1.00 63.34 A C ATOM 441 CG ARG 198 19.643 21.982 4.013 1.00 66.19 A C ATOM 442 CD ARG 198 19.940 20.634 4.643 1.00 67.73 A C ATOM 443 NE ARG 198 18.780 19.756 4.525 1.00 69.43 A N ATOM 444 CZ ARG 198 18.165 19.488 3.377 1.00 69.92 A C ATOM 445 NHl ARG 198 18.605 20.027 2.246 1.00 68.88 A N ATOM 446 NH2 ARG 198 17.099 18.696 3.360 1.00 69.25 A N ATOM 447 C ARG 198 18.395 24.860 5.449 1.00 60.88 A C ATOM 448 O ARG 198 19.338 25.624 5.683 1.00 60.53 A O ATOM 449 N VAL 199 17.263 25.248 4.865 1.00 59.96 A N ATOM 450 CA VAL 199 17.020 26.623 4.438 1.00 58.10 A C ATOM 451 CB VAL 199 15.504 26.878 4.254 1.00 56.40 A C ATOM 452 CGl VAL 199 15.247 28.355 4.006 1.00 54.43 A C ATOM 453 CG2 VAL 199 14.975 26.037 3.101 1.00 54.38 A C ATOM 4 45544 C VAL 199 17.571 27.633 5.437 1.00 57.68 A C ATOM 4 45555 O V VAALL 199 18.558 28.315 5.166 1.00 57.68 A O ATOM 4 45566 N LLEEUU 200 16.927 27.708 6.595 1.00 57.57 A N ATOM 457 CA LEU 200 17.310 28.631 7.660 1.00 58.68 A C ATOM 458 CB LEU 200 16.367 28.451 8.858 1.00 59.07 A C ATOM 459 CG LEU 200 14.864 28.607 8.587 1.00 58.74 A C ATOM 460 CDl LEU 200 14.073 28.090 9.778 1.00 58.58 A C ATOM 461 CD2 LEU 200 14.536 30.070 8.296 1.00 57.21 A C ATOM 462 C LEU 200 18.756 28.453 8.125 1.00 59.31 A C ATOM 4 46633 O O LEU 200 19.397 29.412 8.567 1.00 58.46 A O ATOM 4 46644 N N LYS 201 19.268 27.229 8.019 1.00 59.70 A N ATOM 4 46655 CA LYS 201 20.625 26.941 8.461 1.00 60.66 A C ATOM 4 46666 CB LYS 201 20.795 25.432 8.703 1.00 61.31 A C ATOM 4 46677 CG LYS 201 21.997 25.088 9.578 1.00 62.19 A C ATOM 468 CD LYS 201 21.928 23.673 10.162 1.00 63.13 A C ATOM 469 CE LYS 201 21.999 22.589 9.092 1.00 63.98 A C ATOM 470 Na LYS 201 22.096 21.216 9.681 1.00 63.59 A N ATOM 4 47711 C LYS 201 21.691 27.435 7.493 1.00 60.40 A C ATOM 447722 O LYS 201 22.807 27.756 7.904 1.00 60.95 A O ATOM 447733 N ASN 202 21.341 27.527 6.215 1.00 60.01 A N ATOM 447744 CA ASN 202 22.300 27.960 5.202 1.00 59.42 A C ATOM 475 CB ASN 202 22.489 26.825 4.204 1.00 61.00 A C ATOM 476 CG ASN 202 22.558 25.472 4.886 1.00 62.43 A C ATOM 477 ODl ASN 202 23.527 25.162 5.578 1.00 63.30 A O
ATOM 478 ND2 ASN 202 21.513 24.668 4.715 1.00 63.07 A N
ATOM 479 C ASN 202 21.902 29.239 4.464 1.00 58.17 A C
ATOM 480 0 ASN 202 22.078 29.340 3.249 1.00 57.95 A O
ATOM 481 N THR 203 21.373 30.213 5.202 1.00 55.22 A N
ATOM 482 CA THR 203 20.953 31.482 4.615 1.00 51.49 A C
ATOM 483 CB THR 203 19.470 31.445 4.209 1.00 51.30 A C
ATOM 484 OGl THR 203 18.688 30.979 5.314 1.00 46.78 A O
ATOM 485 CG2 THR 203 19.263 30.526 3.015 1.00 50.95 A C
ATOM 486 C THR 203 21.153 32.648 5.576 1.00 49.94 A C
ATOM 487 0 THR 203 21.093 32.486 6.797 1.00 48.55 A O
ATOM 488 N ARG 204 21.387 33.828 5.013 1.00 48.14 A N
ATOM 489 CA ARG 204 21.589 35.023 5.818 1.00 45.24 A C
ATOM 490 CB ARG 204 23.046 35.471 5.769 1.00 49.54 A C
ATOM 491 CG ARG 204 24.085 34.372 5.797 1.00 55.31 A C
ATOM 492 CD ARG 204 25.496 34.978 5.752 1.00 60.23 A C
ATOM 493 NE ARG 204 25.761 35.856 6.897 1.00 63.23 A N
ATOM 494 CZ ARG 204 25.223 37.063 7.079 1.00 65.37 A C
ATOM 495 NHl ARG 204 24.380 37.572 6.186 1.00 64.95 A N
ATOM 496 NH2 ARG 204 25.517 37.762 8.172 1.00 66.23 A N
ATOM 497 C ARG 204 20.738 36.163 5.281 1.00 40.59 A C
ATOM 498 O ARG 204 20.869 36.544 4.123 1.00 38.79 A O
ATOM 499 N HIS 205 19.876 36.711 6.127 1.00 36.26 A N
ATOM 500 CA HIS 205 19.026 37.822 5.730 1.00 32.28 A C
ATOM 501 CB HIS 205 17.887 37.353 4.824 1.00 29.75 A C
ATOM 502 CG HIS 205 17.066 38.473 4.261 1.00 29.35 A C
ATOM 503 CD2 HIS 205 15.966 39.100 4.741 1.00 30.28 A C
ATOM 504 NDl HIS 205 17.359 39.082 3.061 1.00 26.97 A N
ATOM 505 CEl HIS 205 16.474 40.031 2.822 1.00 28.06 A C
ATOM 506 NE2 HIS 205 15.617 40.063 3.826 1.00 29.50 A N
ATOM 507 C HIS 205 18.450 38.456 6.979 1.00 32.01 A C
ATOM 508 O HIS 205 18.038 37.768 7.911 1.00 30.05 A O
ATOM 509 N PRO 206 18.414 39.789 7.011 1.00 31.68 A N
ATOM 510 CD PRO 206 18.950 40.664 5.957 1.00 33.06 A C
ATOM 511 CA PRO 206 17.899 40.581 8.128 1.00 31.06 A C
ATOM 512 CB PRO 206 17.863 41.991 7.556 1.00 30.89 A C
ATOM 513 CG PRO 206 19.066 41.992 6.674 1.00 33.23 A C
ATOM 514 C PRO 206 16.537 40.143 8.642 1.00 30.37 A C
ATOM 515 O PRO 206 16.268 40.234 9.837 1.00 30.31 A 0
ATOM 516 N PHE 207 15.692 39.642 7.747 1.00 27.98 A N
ATOM 517 CA PHE 207 14.347 39.258 8.136 1.00 27.56 A C
ATOM 518 CB PHE 207 13.362 39.960 7.204 1.00 26.74 A C
ATOM 519 CG PHE 207 13.654 41.425 7.043 1.00 24.77 A C
ATOM 520 CDl PHE 207 13.702 42.252 8.143 1.00 24.16 A C
ATOM 521 CD2 PHE 207 13.932 41.961 5.812 1.00 26.19 A C
ATOM 522 CEl PHE 207 14.020 43.572 8.021 1.00 24.96 A C
ATOM 523 CE2 PHE 207 14.253 43.296 5.683 1.00 26.49 A C
ATOM 524 CZ PHE 207 14.296 44.098 6.789 1.00 24.68 A C
ATOM 525 C PHE 207 14.079 37.768 8.199 1.00 30.00 A C
ATOM 526 O PHE 207 12.928 37.338 8.274 1.00 28.78 A O
ATOM 527 N LEU 208 15.148 36.981 8.176 1.00 31.22 A N
ATOM 528 CA LEU 208 15.032 35.537 8.265 1.00 33.06 A C
ATOM 529 CB LEU 208 15.700 34.862 7.068 1.00 32.37 A C
ATOM 530 CG LEU 208 14.828 34.834 5.816 1.00 34.22 A C
ATOM 531 CDl LEU 208 15.595 34.276 4.632 1.00 33.70 A C
ATOM 532 CD2 LEU 208 13.606 34.003 6.109 1.00 33.04 A C
ATOM 533 C LEU 208 15.706 35.089 9.540 1.00 34.10 A C
ATOM 534 O LEU 208 16.878 35.369 9.750 1.00 34.72 A O
ATOM 535 N THR 209 14.966 34.404 10.402 1.00 36.60 A N
ATOM 536 CA THR 209 15.550 33.923 11.650 1.00 38.70 A C
ATOM 537 CB THR 209 14.527 33.160 12.509 1.00 38.98 A C
ATOM 538 OGl THR 209 13.236 33.754 12.364 1.00 40.78 A O
ATOM 539 CG2 THR 209 14.930 33.223 13.975 1.00 41.17 A C
ATOM 540 C THR 209 16.677 32.952 11.304 1.00 38.74 A C
ATOM 541 O THR 209 16.501 32.059 10.477 1.00 40.12 A O
ATOM 542 N SER 210 17.832 33.117 11.932 1.00 38.87 A N
ATOM 543 CA SER 210 18.945 32.226 11.656 1.00 40.69 A C
ATOM 544 CB SER 210 20.262 32.966 11.861 1.00 41.85 A C
ATOM 545 OG SER 210 21.356 32.127 11.528 1.00 46.48 A O
ATOM 546 C SER 210 18.931 30.975 12.534 1.00 41.04 A C
ATOM 547 O SER 210 18.732 31.065 13.742 1.00 39.33 A O
ATOM 548 N LEU 211 19.122 29.809 11.921 1.00 42.99 A N
ATOM 549 CA LEU 211 19.183 28.538 12.662 1.00 45.67 A C ATOM 550 CB LEU 211 18.536 27.410 11.852 1.00 45.40 A C
ATOM 551 CG LEU 211 18.846 25.970 12.274 1.00 45.86 A C
ATOM 552 CDl LEU 211 18.829 25.853 13.784 1.00 46.90 A C
ATOM 553 CD2 LEU 211 17.829 25.031 11.647 1.00 45.49 A C
ATOM 554 C LEU 211 20.669 28.240 12.889 1.00 47.02 A C
ATOM 555 O LEU 211 21.346 27.721 12.003 1.00 48.27 A O
ATOM 556 N LYS 212 21.170 28.568 14.077 1.00 49.82 A N
ATOM 557 CA LYS 212 22.588 28.395 14.381 1.00 51.72 A C
ATOM 558 CB LYS 212 22.968 29.263 15.578 1.00 51.21 A C
ATOM 559 CG LYS 212 24.368 29.008 16.071 1.00 55.22 A C
ATOM 560 CD LYS 212 24.896 30.186 16.864 1.00 56.87 A C
ATOM 561 CE LYS 212 25.507 31.230 15.946 1.00 58.41 A C
ATOM 562 NZ LYS 212 26.728 30.690 15.283 1.00 58.88 A N
ATOM 563 C LYS 212 23.126 26.984 14.580 1.00 52.25 A C
ATOM 564 O LYS 212 24.092 26.602 13.924 1.00 53.26 A O
ATOM 565 N TYR 213 22.533 26.215 15.484 1.00 53.16 A N
ATOM 566 CA TYR 213 22.993 24.849 15.718 1.00 55.34 A C
ATOM 567 CB TYR 213 23.522 24.689 17.142 1.00 54.19 A C
ATOM 568 CG TYR 213 24.700 25.580 17.459 1.00 54.25 A C
ATOM 569 CDl TYR 213 25.778 25.674 16.589 1.00 54.15 A C
ATOM 570 CEl TYR 213 26.865 26.474 16.883 1.00 54.37 A C
ATOM 571 CD2 TYR 213 24.744 26.312 18.637 1.00 53.30 A C
ATOM 572 CE2 TYR 213 25.828 27.110 18.940 1.00 53.8 822 A C
ATOM 573 CZ TYR 213 26.886 27.188 18.060 1.00 54.4433 A C
ATOM 574 OH TYR 213 27.972 27.979 18.361 1.00 54.4411 A O
ATOM 575 C TYR 213 21.849 23.883 15.492 .00 57.47 A C
ATOM 576 O TYR 213 20.692 24.216 15.742 .00 57.85 A O
ATOM 577 N SER 214 22.163 22.686 15.019 .00 61.03 A N
ATOM 578 CA SER 214 21.119 21.709 14.759 .00 64.95 A C
ATOM 579 CB SER 214 20.813 21.644 13.269 .00 64.57 A C
ATOM 580 OG SER 214 19.771 20.720 13.031 .00 66.44 A O
ATOM 581 C SER 214 21.452 20.316 15.251 .00 67.69 A C
ATOM 582 O SER 214 21.269 19.335 14.526 .00 69.40 A O
ATOM 583 N PHE 215 21.940 20.228 16.483 .00 69.79 A N
ATOM 584 CA PHE 215 22.278 18.939 17.068 .00 71.84 A C
ATOM 585 CB PHE 215 23.105 19.137 18.343 1.00 72.06 A C
ATOM 586 CG PHE 215 22.352 19.812 19.453 00 72.43 A C
ATOM 587 CDl PHE 215 22.886 20.916 20.098 00 72.71 A C
ATOM 588 CD2 PHE 215 21.115 19.337 19.862 00 71.76 A C
ATOM 589 CEl PHE 215 22.200 21.533 21.131 00 72.44 A C
ATOM 590 CE2 PHE 215 20.427 19.949 20.893 00 71.80 A C
ATOM 591 CZ PHE 215 20.969 21.047 21.528 1.00 71.89 A C
ATOM 592 C PHE 215 20.993 18.188 17.398 1.00 72.83 A C
ATOM 593 O PHE 215 19.893 18.731 17.290 1.00 72.87 A O
ATOM 594 N GLN 216 21.140 16.933 17.797 1.00 74.66 A N
ATOM 595 CA GLN 216 19.997 16.109 18.158 1.00 76.80 A C
ATOM 596 CB GLN 216 19.421 15.417 16.924 1.00 76.73 A C
ATOM 597 CG GLN 216 20.432 14.559 16.179 1.00 77.33 A C
ATOM 598 CD GLN 216 19.788 13.704 15.106 77.76 A C
ATOM 599 OEl GLN 216 18.957 12.842 15.402 76.81 A O
ATOM 600 NE2 GLN 216 20.168 13.937 13.852 77.63 A N
ATOM 601 C GLN 216 20.485 15.065 19.143 78.15 A C
ATOM 602 O GLN 216 21.686 14,795 19.217 1.00 78.22 A O
ATOM 603 N THR 217 19.562 14.485 19.901 1.00 79.58 A N
ATOM 604 CA THR 217 19.922 13.459 20.873 1.00 81.62 A C
ATOM 605 CB THR 217 19.804 13.981 22.318 1.00 80.76 A C
ATOM 606 OGl THR 217 18.459 14.414 22.558 1.00 80.48 A O
ATOM 607 CG2 THR 217 20.773 15.140 22.553 1.00 79.52 A C
ATOM 608 C THR 217 18.997 12.260 20.717 1.00 83.49 A C
ATOM 609 O THR 217 17.944 12.200 21.356 1.00 84.03 A O
ATOM 610 N LYS 218 19.398 11.310 19.871 1.00 84.94 A N
ATOM 611 CA LYS 218 18.595 10.115 19.622 1.00 86.22 A C
ATOM 612 CB LYS 218 18.845 9.059 20.709 1.00 86.38 A C
ATOM 613 CG LYS 218 18.550 9.526 22.133 1.00 86.70 A C
ATOM 614 CD LYS 218 18.463 8.347 23.093 1.00 86.94 A C
ATOM 615 CE LYS 218 17.379 7.368 22.656 1.00 86.77 A C
ATOM 616 NZ LYS 218 17.237 6.219 23.588 1.00 86.56 A N
ATOM 617 C LYS 218 17.133 10.537 19.638 1.00 86.77 A C
ATOM 618 O LYS 218 16.557 10.879 18.601 1.00 87.12 A O
ATOM 619 N ASP 219 16.543 10.508 20.828 1.00 86.45 A N
ATOM 620 CA ASP 219 15.166 10.921 21.015 1.00 86.27 A C
ATOM 621 CB ASP 219 14.479 10.029 22.048 1.00 88.27 A C
ATOM 622 CG ASP 219 14.298 8.606 21.558 1.00 89.69 A C ATOM 623 ODl ASP 219 13.752 8.432 20.445 1.00 90.61 A O
ATOM 624 OD2 ASP 219 14.695 7.666 22.283 1.00 90.08 A O
ATOM 625 C ASP 219 15.192 12.364 21.501 1.00 84.89 A C
ATOM 626 O ASP 219 15.574 12.637 22.640 1.00 84.28 A O
ATOM 627 N ARG 220 14.801 13.278 20.617 1.00 83.45 A N
ATOM 628 CA ARG 220 14.774 14.703 20.922 1.00 82.01 A C
ATOM 629 CB ARG 220 15.654 15.002 22.144 1.00 83.21 A C
ATOM 630 CG ARG 220 15.988 16.476 22.320 1.00 85.47 A C
ATOM 631 CD ARG 220 16.778 16.751 23.595 1.00 86.39 A C
ATOM 632 NE ARG 220 15.943 16.689 24.792 1.00 87.69 A N
ATOM 633 CZ ARG 220 16.369 16.998 26.012 1.00 88.10 A C
ATOM 634 NHl ARG 220 17.624 17.391 26.194 1.00 88.58 A N
ATOM 635 NH2 ARG 220 15.542 16.924 27.047 1.00 88.36 A N
ATOM 636 C ARG 220 15.243 15.547 19.735 1.00 79.69 A C
ATOM 637 O ARG 220 16.421 15.517 19.366 1.00 79.56 A O
ATOM 638 N LEU 221 14.317 16.292 19.136 1.00 76.76 A N
ATOM 639 CA LEU 221 14.654 17.158 18.008 1.00 74.66 A C
ATOM 640 CB LEU 221 13.437 17.368 17.110 .1.00 75.26 A C
ATOM 641 CG LEU 221 13.654 18.390 15.992 1.00 76.34 A C
ATOM 642 CDl LEU 221 13.649 19.809 16.555 1.00 75.98 A C
ATOM 643 CD2 LEU 221 14.974 18.080 15.295 1.00 76.49 A C
ATOM 644 C LEU 221 15.141 18.504 18.539 1.00 72.12 A C
ATOM 645 O LEU 221 14.486 19:111 19.387 1.00 71.75 A O
ATOM 646 N CYS 222 16.281 18.973 18.036 1.00 69.07 A N
ATOM 647 CA CYS 222 16.835 20.236 18.509 1.00 65.90 A C
ATOM 648 CB CYS 222 17.910 19.964 19.559 1.00 65.74 A C
ATOM 649 SG CYS 222 17.293 19.192 21.071 1.00 68.04 A S
ATOM 650 C CYS 222 17.405 21.176 17.453 1.00 63.31 A C
ATOM 651 O CYS 222 18.233 20.792 16.627 1.00 62.69 A O
ATOM 652 N PHE 223 16.957 22.425 17.519 1.00 60.62 A N
ATOM 653 CA PHE 223 17.396 23.472 16.613 1.00 57.16 A C
ATOM 654 CB PHE 223 16.321 23.752 15.568 1.00 60.29 A C
ATOM 655 CG PHE 223 16.032 22.589 14.666 1.00 63.26 A C
ATOM 656 CDl PHE 223 17.022 22.069 13.846 1.00 63.84 A C
ATOM 657 CD2 PHE 223 14.761 22.031 14.617 1.00 64.91 A C
ATOM 658 CEl PHE 223 16.750 21.017 12.994 1.00 65.10 A C
ATOM 659 CE2 PHE 223 14.480 20.977 13.766 1.00 64.87 A C
ATOM 660 CZ PHE 223 15.475 20.469 12.953 1.00 65.34 A C
ATOM 661 C PHE 223 17.640 24.741 17.421 1.00 54.08 A C
ATOM 662 O PHE 223 16.721 25.270 18.044 1.00 53.41 A O
ATOM 663 N VAL 224 18.877 25.224 17.417 1.00 49.81 A N
ATOM 664 CA VAL 224 19.217 26.444 18.142 1.00 46.30 A C
ATOM 665 CB VAL 224 20.668 26.388 18.677 1.00 44.84 A C
ATOM 666 CGl VAL 224 21.041 27.714 19.337 1.00 42.31 A C
ATOM 667 CG2 VAL 224 20.797 25.247 19.675 1.00 42.59 A C
ATOM 668 C VAL 224 19.051 27.629 17.193 1.00 44.10 A C
ATOM 669 O VAL 224 19.815 27.807 16.245 1.00 43.34 A O
ATOM 670 N MET 225 18.047 28.446 17.467 1.00 42.70 A N
ATOM 671 CA MET 225 17.744 29.584 16.619 1.00 41.81 A C
ATOM 672 CB MET 225 16.325 29.426 16.079 1.00 43.64 A C
ATOM 673 CG MET 225 16.076 28.051 15.501 1.00 45.88 A C
ATOM 674 SD MET 225 14.467 27.906 14.731 1.00 51.87 A S
ATOM 675 CE MET 225 13.631 26.850 15.885 1.00 49.38 A C
ATOM 676 C MET 225 17.881 30.948 17.274 1.00 39.84 A C
ATOM 677 O MET 225 17.916 31.073 18.492 1.00 39.46 A O
ATOM 678 N GLU 226 17.955 31.964 16.426 1.00 38.72 A N
ATOM 679 CA GLU 226 18.058 33.353 16.834 1.00 37.49 A C
ATOM 680 CB GLU 226 18.088 34.230 15.582 1.00 39.21 A C
ATOM 681 CG GLU 226 17.636 35.672 15.767 1.00 41.52 A C
ATOM 682 CD GLU 226 17.992 36.548 14.563 1.00 41.81 A C
ATOM 683 OEl GLU 226 17.766 36.114 13.406 1.00 38.85 A O
ATOM 684 OE2 GLU 226 18.497 37.672 14.783 1.00 41.91 A O
ATOM 685 C GLU 226 16.848 33.681 17.694 1.00 37.66 A C
ATOM 686 O GLU 226 15.724 33.317 17.360 1.00 37.96 A O
ATOM 687 N TYR 227 17.078 34.372 18.804 1.00 36.86 A N
ATOM 688 CA TYR 227 16.002 34.716 19.725 1.00 33.76 A C
ATOM 689 CB TYR 227 16.544 34.697 21.164 1.00 31.43 A C
ATOM 690 CG TYR 227 15.517 35.070 22.200 1.00 31.12 A C
ATOM 691 CDl TYR 227 14.270 34.449 22.217 1.00 31.65 A C
ATOM 692 CEl TYR 227 13.292 34.823 23.125 1.00 31.28 A C
ATOM 693 CD2 TYR 227 15.766 36.077 23.134 1.00 30.89 A C
ATOM 694 CE2 TYR 227 14.793 36.457 24.050 1.00 31.86 A C
ATOM 695 CZ TYR 227 13.554 35.824 24.035 1.00 32.24 A C ATOM 596 OH TYR 227 12.558 36.204 24.904 1.00 32.17 A O
ATOM 697 C TYR 227 15.338 36.062 19.424 1.00 33.64 A C
ATOM 698 O TYR 227 15.997 37.093 19.443 1.00 31.36 A O
ATOM 699 N VAL 228 14.038 36.044 19.128 1.00 32.62 A N
ATOM 700 CA VAL 228 13.294 37.278 18.861 1.00 34.22 A C
ATOM 701 CB VAL 228 12.712 37.333 17.420 1.00 34.26 A C
ATOM 702 CGl VAL 228 13.773 37.804 16.456 1.00 35.10 A C
ATOM 703 CG2 VAL 228 12.201 35.971 17.003 1.00 35.98 A C
ATOM 704 C VAL 228 12.157 37.392 19.863 1.00 34.84 A C
ATOM 705 O VAL 228 11.319 36.497 19.972 1.00 33.76 A - O
ATOM 706 N ASN 229 12.131 38.506 20.585 1.00 35.32 A N
ATOM 707 CA ASN 229 11.130 38.727 21.624 1.00 36.55 A C
ATOM 708 CB ASN 229 11.846 38.888 22.960 1.00 37.09 A C
ATOM 709 CG ASN 229 12.798 40.065 22.964 1.00 39.31 A C
ATOM 710 ODl ASN 229 13.354 40.433 21.928 1.00 38.77 A O
ATOM 711 ND2 ASN 229 13.005 40.654 24.133 1.00 40.55 A N
ATOM 712 C ASN 229 10.219 39.931 21.391 1.00 35.61 A C
ATOM 713 O ASN 229 9.795 40.583 22.344 1.00 36.30 A O
ATOM 714 N GLY 230 9.9-22 40.221 20.129 1.00 34.73 A N
ATOM 715 CA GLY 230 9.060 41.345 19.807 1.00 31.74 A C
ATOM 716 C GLY 230 7.617 40.900 19.763 1.00 31.63 A C
ATOM 717 O GLY 230 6.706 41.729 19.721 1.00 29.63 A O
ATOM 718 N GLY 231 7.419 39.582 19.752 1.00 31.75 A N
ATOM 719 CA GLY 231 6.081 39.025 19.740 1.00 34.98 A C
ATOM 720 C GLY 231 5.575 38.441 18.431 1.00 39.49 A C
ATOM 721 O GLY 231 6.018 38.821 17.343 1.00 41.16 A O
ATOM 722 N GLU 232 4.641 37.502 18.543 1.00 40.56 A N
ATOM 723 CA GLU 232 4.028 36.872 17.380 1.00 43.34 A C
ATOM 724 CB GLU 232 3.172 35.680 17.827 1.00 46.81 A C
ATOM 725 CG GLU 232 3.665 34.322 17.353 1.00 52.52 A C
ATOM 726 CD GLU 232 3.833 34.272 15.845 1.00 57.31 A C
ATOM 727 OEl GLU 232 2.877 34.643 15.119 1.00 57.32 A O
ATOM 728 OE2 GLU 232 4.924 33.859 15.386 1.00 60.29 A O
ATOM 729 C GLU 232 3.133 37.898 16.681 1.00 42.74 A C
ATOM 730 O GLU 232 2.282 38.517 17.318 1.00 42.18 A O
ATOM ■ 731 N LEU 233 3.319 38.096 15.382 1.00 41.30 A N
ATOM 732 CA LEU 233 2.470 39.048 14.689 1.00 41.43 A C
ATOM 733 CB LEU 233 2.808 39.124 13.201 1.00 41.20 A C
ATOM 734 CG LEU 233 3.654 40.337 12.820 1.00 41.91 A C
ATOM 735 CDl LEU 233 3.675 40.471 11.314 1.00 41.23 A C
ATOM 736 CD2 LEU 233 3.073 41.603 13.453 1.00 40.96 A C
ATOM 737 C LEU 233 1.030 38.601 14.861 1.00 42.48 A C
ATOM 738 O LEU 233 0.129 39.423 15.061 1.00 42.54 A O
ATOM 739 N PHE 234 0.812 37.295 14.778 1.00 41.70 A N
ATOM 740 CA PHE 234 -0.521 36.760 14.946 1.00 43.75 A C
ATOM 741 CB PHE 234 -0.464 35.236 15.038 1.00 45.26 A C
ATOM 742 CG PHE 234 -1.799 34.589 15.282 1.00 47.95 A C
ATOM 743 CDl PHE 234 -2.458 34.754 16.491 1.00 50.46 A C
ATOM 744 CD2 PHE 234 -2.386 33.799 14.309 1.00 49.36 A C
ATOM 745 CEl PHE 234 -3.679 34.140 16.727 1.00 50.67 A C
ATOM 746 CE2 PHE 234 -3.606 33.184 14.538 1.00 50.93 A C
ATOM 747 CZ PHE 234 -4.252 33.354 15.749 1.00 50.60 A C
ATOM 748 C PHE 234 -1.130 37.346 16.214 1.00 44.00 A C
ATOM 749 O PHE 234 -2.285 37.747 16.230 1.00 43.56 A O
ATOM 750 N PHE 235 -0.335 37.411 17.274 1.00 45.97 A N
ATOM 751 CA PHE 235 -0.798 37.947 18.548 1.00 47.08 A C
ATOM 752 CB PHE 235 0.244 37.677 19.634 1.00 50.49 A C
ATOM 753 CG PHE 235 -0.077 38.315 20.954 1.00 56.08 A C
ATOM 754 CDl PHE 235 -1.220 37.959 21.654 1.00 58.49 A C
ATOM 755 CD2 PHE 235 0.762 39.280 21.496 1.00 58.60 A C
ATOM 755 CEl PHE 235 -1.520 38.556 22.872 1.00 59.42 A C
ATOM 757 CE2 PHE 235 0.467 39.881 22.716 1.00 59.61 A C
ATOM 758 CZ PHE 235 -0.675 39.517 23.402 1.00 60.06 A C
ATOM 759 C PHE 235 -1.071 39.443 18.448 1.00 46.11 A C
ATOM 760 O PHE 235 -2.136 39.916 18.846 1.00 46.04 A O
ATOM 761 N HIS 236 -0.105 40.189 17.927 1.00 44.31 A N
ATOM 762 CA HIS 236 -0.271 41.627 17.769 1.00 43.27 A C
ATOM 763 CB HIS 236 0.932 42.227 17.055 1.00 41.65 A C
ATOM 764 CG HIS 236 2.191 42.181 17.856 1.00 40.05 A C
ATOM 765 CD2 HIS 236 3.358 41.529 17.646 1.00 41.02 A C
ATOM 766 NDl HIS 236 2.347 42.880 19.033 1.00 39.77 A N
ATOM 767 CEl HIS 236 3.558 42.664 19.512 1.00 41.61 A C
ATOM 768 NE2 HIS 236 4.192 41.848 18.689 1.00 41.06 A N ATOM 769 C HIS 236 -1.519 41.924 16.954 1.00 43.75 A C
ATOM 770 O HIS 236 -2.365 42.717 17.367 1.00 44.86 A O
ATOM 771 N LEU 237 -1.619 41.293 15.789 1.00 42.87 A N
ATOM 772 CA LEU 237 -2.762 41.485 14.909 00 43.90 A C
ATOM 773 CB LEU 237 -2.600 40.623 13.650 00 41.35 A C
ATOM 774 CG LEU 237 -3.620 40.653 12.509 00 39.85 A C
ATOM 775 CDl LEU 237 -4.891 39.990 12.964 00 40.65 A C
ATOM 776 CD2 LEU 237 -3.881 42.081 12.061 00 37.34 A C
ATOM 777 C LEU 237 -3.996 41.071 15.690 00 46.70 A C
ATOM 778 O LEU 237 -5.008 41.768 15.689 00 46.05 A O
ATOM 779 N SER 238 -3.891 39.935 16.374 00 49.81 A N
ATOM 780 CA SER 238 -4.986 39.411 17.175 00 52.65 A C
ATOM 781 CB SER 238 -4.812 37.908 17.391 00 54.35 A C
ATOM 782 OG SER 238 -4.800 37.218 16.144 00 57.49 A O
ATOM 783 C SER. 238 -5.033 40.131 18.515 00 54.32 A C
ATOM 784 O SER 238 -5.004 39.509 19.580 1.00 55.53 A O
ATOM 785 N ARG 239 -5.094 41.453 18.439 .00 54.62 A N
ATOM 786 CA ARG 239 -5.160 42.316 19.604 .00 55.59 A C
ATOM 787 CB ARG 239 -3. .820 42.380 20.336 .00 59.17 A C
ATOM 788 CG ARG 239 -3,.640 41.353 21.447 1.00 64.08 A C
ATOM 789 CD ARG 239 -2.619 41.825 22.494 00 68.46 A C
ATOM 790 NE ARG 239 -1.347 42.235 21.897 00 73.06 A N
ATOM 791 CZ ARG 239 -1.141 43.398 21.280 00 75.42 A C
ATOM 792 NHl ARG 239 -2.125 44.288 21.180 00 77.01 A N
ATOM 793 NH2 ARG 239 0.044 43.668 20.743 00 75.29 A N
ATOM 794 C ARG 239 -5.505 43.695 19.094 00 54.93 A C
ATOM 795 O ARG 239 -5.744 44.617 19.870 00.55.93 A O
ATOM 796 N GLU 240 -5.521 43.832 17.775 00 52,81 A N
ATOM 797 CA GLU 240 -5.834 45.105 17.158 1.00 49.77 A C
ATOM 798 CB GLU 240 -4.557 45.756 16.657 1.00 51.14 A C
ATOM 799 CG GLU 240 -3.710 46.275 17.788 1.O0 53.50 A C
ATOM 800 CD GLU 240 -2.588 47.143 17.293 1.00 57.24 A C
ATOM 801 OEl GLU 240 -1.611 46.575 16.757 1.00 60.17 A O
ATOM 802 OE2 GLU 240 -2.691 48.386 17.427 1.00 55.39 A O
ATOM 803 C GLU 240 -6.833 44.955 16.032 1.00 48.09 A C
ATOM 804 O GLU 240 -7.324 45.939 15.485 1.00 47.93 A O
ATOM 805 N ARG 241 -7.140 43.711 15.701 1.00 45.32 A N
ATOM 806 CA ARG 241 -8.099 43.416 14.654 1.00 44.32 A C
ATOM 807 CB ARG 241 -9.333 44.316 14.800 1.00 48.15 A C
ATOM 808 CG ARG 241 -9.944 44.356 16.203 1.00 53.31 A C
ATOM 809 CD ARG 241 -10.137 42.959 16.780 1.00 57.37 A C
ATOM 810 NE ARG 241 -8.864 42.366 17.192 1.00 61.90 A N
ATOM 811 CZ ARG 241 -8.705 41.098 17.565 1.O0 63.06 A C
ATOM 812 NHl ARG 241 -9.741 40.269 17.581 00 64.20 A N
ATOM 813 NH2 ARG 241 -7.506 40.658 17.923 00 62.40 A N
ATOM 814 C ARG 241 -7.476 43.616 13.282 00 41.17 A C
ATOM 815 O ARG 241 -7.370 42.676 12.490 00 39.13 A O
ATOM 816 N VAL 242 -7.061 44.845 13.009 00 38.35 A N
ATOM 817 CA VAL 242 -6.453 45.175 11.734 1.00 36.77 A C
ATOM 818 CB VAL 242 -7.486 45.821 10.804 1.00 37.65 A C
ATOM 819 CGl VAL 242 -8.329 46.797 11.582 1.00 38.12 A C
ATOM 820 CG2 VAL 242 -6.793 46.543 9.678 1.00 38.52 A C
ATOM 821 C VAL 242 -5.275 46.126 11.903 1.00 34.44 A C
ATOM 822 O VAL 242 -5.173 46.825 12.903 1.00 33.73 A O
ATOM 823 N PHE 243 -4.365 46.114 10.937 1.00 32.33 A N
ATOM 824 CA PHE 243 -3.221 47.013 10.965 1.00 29.60 A C
ATOM 825 CB PHE 243 -1.906 46.310 10.587 1.00 29.31 A C
ATOM 826 CG PHE 243 -1.434 45.282 11.583 1.00 28.46 A C
ATOM 827 CDl PHE 243 -1.771 45.373 12.918 1.00 27..06 A C
ATOM 828 CD2 PHE 243 -0.603 44.246 11.178 1.00 26.96 A C
ATOM 829 CEl PHE 243 -1.289 44.451 13.830 1.00 27.15 A C
ATOM 830 CE2 PHE 243 -0.120 43.326 12.082 1.00 28.90 A C
ATOM 831 CZ PHE 243 -0.462 43.427 13.412 1.00 29.15 A C
ATOM 832 C PHE 243 -3.503 48.068 9.907 1.O0 28.42 A C
ATOM 833 O PHE 243 -4.263 47.828 8.961 1.00 28.58 A O
ATOM 834 N SER 244 -2.887 49.232 10.064 1.00 26.52 A N
ATOM 835 CA SER 244 -3.050 50.307 9.104 1.00 26.25 A C
ATOM 836 CB SER 244 -2.362 51.555 9.626 1.00 26.34 A C
ATOM 837 OG SER 244 -0.971 51.311 9.726 1.00 26.48 A O
ATOM 838 C SER 244 -2.363 49.867 7.806 1.00 26.96 A C
ATOM 839 O SER 244 -1.497 48.985 7.821 1.00 24.22 A O
ATOM 840 N GLU 245 -2.735 50.486 6.690 1.00 26.34 A N
ATOM 841 CA GLU 245 -2.117 50.141 5.420 1.00 26.90 A C ATOM 842 CB GLU 245 2.741 50.947 4.274 1.00 24.23 A C
ATOM 843 CG GI1U 245 4.180 50.548 4.038 1.00 26.72 A C
ATOM 844 CD GLU 245 4.725 50.936 2.677 1.00 30.55 A C
ATOM 845 OEl GLU 245 3.935 51.060 1.714 1.00 31.16 A O
ATOM 846 OE2 GLU 245 5.961 51.090 2.566 1.00 31.43 A O
ATOM 847 C GLU 245 0.619 50.391 5.522 1.00 28.73 A C
ATOM 848 O GLU 245 0.178 49.581 5.066 1.00 28.51 A O
ATOM 849 N ASP 246 0.239 51.496 6.148 1.00 30.60 A N
ATOM 850 CA ASP 246 1.172 51.820 6.314 1.00 33.59 A C
ATOM 851 CB ASP 246 1.324 53.135 7.071 1.00 37.60 A C
ATOM 852 CG ASP 246 1.237 54.342 6.164 1.00 42.65 A C
ATOM 853 ODl ASP 246 0.345 54.371 5.287 1.00 46.29 A O
ATOM 854 OD2 ASP 246 2.059 55.268 6.333 1.00 46.30 A O
ATOM 855 C ASP 246 1.932 50.737 7.064 1.00 34.24 A C
ATOM 856 O ASP 246 3.001 50.311 6.634 1.00 35.78 A O
ATOM 857 N ARG 247 1.373 50.309 8.194 1.00 33.78 A N
ATOM 858 CA ARG 247 1.979 49.282 9.035 1.00 30.31 A C
ATOM 859 CB ARG 247 1.080 48.980 10.243 1.00 30.15 A C
ATOM 860 CG ARG 247 1.813 48.889 11.557 1.00 31.09 A C
ATOM 861 CD ARG 247 1.741 47.516 12.204 1.00 32.29 A C
ATOM 862 NE ARG 247 1.014 47.584 13.466 1.00 34.64 A N
ATOM 863 CZ ARG 247 1.255 46.834 14.537 1.00 35.97 A C
ATOM 864 NHl ARG 247 2.222 45.932 14.535 1.00 37.04 A N
ATOM 865 NH2 ARG 247 0.520 46.993 15.625 1.00 35.10 A N
ATOM 866 C ARG 247 2.153 48.0-19 8.220 1.00 27.14 A C
ATOM 867 O ARG 247 3.184 47.361 8.290 1.00 29.36 A O
ATOM 868 N THR 248 1.129 47.691 7.448 1.00 23.48 A N
ATOM 869 CA THR 248 1.143 46.494 6.627 1.00 23.32 A C
ATOM 870 CB THR 248 0.261 46.214 6.021 1.00 22.83 A C
ATOM 871 OGl THR 248 1.221 46.124 7.081 1.00 22.53 A O
ATOM 872 CG2 THR 248 0.264 44.907 5.231 1.00 18.76 A C
ATOM 873 C THR "248 2.167 46.631 5.507 1.00 23.30 A C
ATOM 874 O THR 248 2.835 45.661 5.155 1.00 22.75 A O
ATOM 875 N ARG 249 2.290 47.836 4.959 1.00 21.60 A N
ATOM 876 CA ARG 249 3.240 48.079 3.881 1.00 22.73 A C
ATOM 877 CB ARG 249 3.103 49.499 3.338 1.00 21.81 A C
ATOM 878 CG ARG 249 4.282 49.948 2.485 1.00 20.68 A C
ATOM 879 CD ARG 249 3.910 51.146 1.625 1.00 23.94 A C
ATOM 880 NE ARG 249 3.015 52.028 2.353 1.00 27.83 A N
ATOM 881 CZ ARG 249 1.777 52.329 1.977 1.00 27.99 A C
ATOM 882 NHl ARG 249 1.266 51.833 0.860 1.00 26.87 A N
ATOM 883 NH2 ARG 249 1.038 53.105 2.754 1.00 31.60 A N
ATOM 884 C ARG 249 4.650 47.866 4.387 1.00 22.35 A C
ATOM 885 O ARG 249 5.517 47.374 3.668 1.00 24.12 A O
ATOM 886 N PHE 250 4.862 48.239 5.635 1.00 20.47 A N
ATOM 887 CA PHE 250 6.153 48.090 6.260 1.00 21.09 A C
ATOM 888 CB PHE 250 6.114 48.695 7.657 1.00 22.04 A C
ATOM 889 CG PHE 250 7.381 48.531 8.395 1.00 24.56 A C
ATOM 890 CDl PHE 250 8.482 49.308 8.075 1.00 23.96 A C
ATOM 891 CD2 PHE 250 7.506 47.550 9.360 1.00 22.12 A C
ATOM 892 CEl PHE 250 9.703 49.104 8.707 1.00 25.48 A C
ATOM 893 CE2 PHE 250 8.716 47.339 9.994 1.00 26.28 A C
ATOM 894 CZ PHE 250 9.816 48.112 9.668 1.00 24.70 A C
ATOM 895 C PHE 250 6.546 46.610 6.358 1.00 22.97 A C
ATOM 896 O PHE 250 7.641 46.220 5.950 1.00 21.28 A O
ATOM 897 N TYR 251 5.648 45.791 6.908 1.00 22.46 A N
ATOM 898 CA TYR 251 5.919 44.361 7.051 1.00 22.41 A C
ATOM 899 CB TYR 251 4.830 43.691 7.892 1.00 23.94 A C
ATOM 900 CG TYR 251 4.726 44.261 9.291 1.00 23.03 A C
ATOM 901 CDl TYR 251 5.871 44.589 10.015 1.00 23.28 A C
ATOM 902 CEl TYR 251 5.790 45.087 11.302 1.00 21.45 A C
ATOM 903 CD2 TYR 251 3.495 44.453 9.895 1.00 22.91 A C
ATOM 904 CE2 TYR 251 3.403 44.954 11.188 1.00 22.51 A C
ATOM 905 CZ TYR 251 4.550 45.263 11.885 1.00 20.06 A C
ATOM 906 OH TYR 251 4.460 45.711 13.184 1.00 22.53 A O
ATOM 907 C TYR 251 6.042 43.662 5.702 1.00 21.27 A C
ATOM 908 O TYR 251 6.954 42.867 5.496 1.00 22.58 A O
ATOM 909 N GLY 252 5.136 43.975 4.783 1.00 19.97 A N
ATOM 910 CA GLY 252 5.179 43.371 3.465 1.00 20.03 A C
ATOM 911 C GLY 252 6.480 43.649 2.737 1.00 20.82 A C
ATOM 912 0 GLY 252 7.014 42.776 2.045 1.00 20.97 A O
ATOM 913 N ALA 253 6.989 44.871 2.893 1.00 20.57 A N
ATOM 914 CA ALA 253 8.238 45.277 2.256 1.00 19.67 A C ATOM 915 CB ALA 253 8.540 46.721 2.585 1.00 18.48 A C
ATOM 916 C AIiA 253 9.382 44.377 2.731 1.00 19.96 A C
ATOM 917 O ALA 253 10.164 43.856 1.929 1.00 19.14 A O
ATOM 918 N GLU 254 9.457 44.183 4.042 1.00 20.92 A N
ATOM 919 CA GLU 254 10.491 43.350 4.619 1.00 21.72 A C
ATOM 920 CB GLU 254 10.510 43.527 6.126 1.00 20.24 A C
ATOM 921 CG GLU 254 10.618 44.971 6.511 1.00 21.75 A C
ATOM 922 CD GLU 254 11.150 45.162 7.908 1.00 23.51 A C
ATOM 923 OEl GLU 254 10.703 44.433 8.812 1.00 24.02 A O
ATOM 924 OE2 GLU 254 12.013 46.050 8.101 1.00 27.35 A O
ATOM 925 C GLU 254 10.290 41.892 4.251 1.00 23.05 A C
ATOM 926 O GLU 254 11.247 41.159 4.051 1.00 23.28 A O
ATOM 927 N ILE 255 9.044 41.463 4.153 1.00 24.52 A N
ATOM 928 CA ILE 255 8.805 40.084 3.778 1.00 25.38 A C
ATOM 929 CB ILE 255 7.314 39.724 3.895 1.00 25.93 A C
ATOM 930 CG2 ILE 255 7.050 38.400 3.216 1.00 25.70 A C
ATOM 931 CGl ILE 255 6.907 39.677 5.374 1.00 26.50 A C
ATOM 932 CDl ILE 255 5.418 39.472 5.597 1.00 26.53 A C
ATOM 933 C ILE 255 9.269 39.941 2.339 1.00 26.38 A C
ATOM 934 O ILE 255 10.031 39.034 2.012 1.00 27.74 A O
ATOM 935 N VAL 256 8.827 40.867 1.492 1.00 24.20 A N
ATOM 936 CA VAL 256 9.193 40.868 0.077 1.00 23.90 A C
ATOM 937 CB VAL 256 8.649 42.138 -0.648 1.00 23.03 A C
ATOM 938 CGl VAL 256 9.43S 42.393 -1.935 1.00 17.92 A C
ATOM 939 CG2 VAL 256 7.162 41.968 -0.946 1.00 20.34 A C
ATOM 940 C VAL 256 10.702 40.820 -0.090 1.00 24.45 A C
ATOM 941 O VAL 256 11.217 40.116 -0.966 1.00 24.67 A O
ATOM 942 N SER 257 11.412 41.567 0.749 1.00 23.77 A N
ATOM 943 CA SER 257 12.864 41.598 0.660 1.00 24.95 A C
ATOM 944 CB SER 257 13.440 42.646 1.604 1.00 25.03 A C
ATOM 945 OG SER 257 14.853 42.694 1.502 1.00 27.83 A O
ATOM 946 C SER 257 13.443 40.230 0.991 1.00 26.73 A C
ATOM 947 O SER 257 14.417 39.789 0.373 1.00 27.11 A O
ATOM 948 N ALA 258 12.827 39.554 1.954 1.00 25.66 A N
ATOM 949 CA ALA 258 13.286 38.242 2.355 1.00 26.37 A C
ATOM 950 CB ALA 258 12.550 37.782 3.610 1.00 25.62 A C
ATOM 951 C ALA 258 13.076 37.240 1.232 1.00 27.09 A C
ATOM 952 O ALA 258 13.989 36.508 0.871 1.00 28.20 A O
ATOM 953 N LEU 259 11.874 37.215 0.671 1.00 27.49 A N
ATOM 954 CA LEU 259 11.572 36.268 -0.393 1.00 26.34 A C
ATOM 955 CB LEU 259 10.074 36.314 -0.733 1.00 23.85 A C
ATOM 956 CG LEU 259 9.147 35.879 0.421 1.00 25.48 A C
ATOM 957 CDl LEU 259 7.669 36.002 0.019 1.00 22.61 A C
ATOM 958 CD2 LEU 259 9.474 34.436 0.805 1.00 23.99 A C
ATOM 959 C LEU 259 12.429 36.516 -1.628 1.00 25.45 A C
ATOM 960 O LEU 259 12.918 35.573 -2.247 1.00 25.38 A O
ATOM 961 N ASP 260 12.622 37.780 -1.983 1.00 25.18 A N
ATOM 962 CA ASP 260 13.446 38.110 -3.142 1.00 24.12 A C
ATOM 963 CB ASP 260 13.662 39.622 -3.202 1.00 23.75 A C
ATOM 964 CG ASP 260 14.453 40.066 -4.415 1.00 20.35 A C
ATOM 965 ODl ASP 260 14.696 39.249 -5.319 1.00 21.46 A O
ATOM 966 0D2 ASP 260 14.822 41.255 -4.476 1.00 20.64 A O
ATOM 967 C ASP 260 14.790 37.402 -2.974 1.00 26.63 A C
ATOM 968 O ASP 260 15.343 36.836 -3.926 1.00 27.00 A O
ATOM 969 N TYR 261 15.299 37.434 -1.746 1.00 26.00 A N
ATOM 970 CA TYR 261 16.570 36.818 -1.421 1.00 26.39 A C
ATOM 971 CB TYR 261 16.916 37.113 0.029 1.00 27.05 A C
ATOM 972 CG TYR 261 18.051 36.282 0.574 1.00 29.42 A C
ATOM 973 CDl TYR 261 19.374 36.547 0.219 1.00 31.32 A C
ATOM 974 CEl TYR 261 20.415 35.807 0.743 1.00 30.53 A C
ATOM 975 CD2 TYR 261 17.805 35.248 1.462 1.00 29.32 A C
ATOM 976 CE2 TYR 261 18.827 34.509 1.988 1.00 31.49 A C
ATOM 977 CZ TYR 261 20.132 34.792 1.633 1.00 33.11 A C
ATOM 978 OH TYR 261 21.149 34.074 2.211 1.00 36.78 A O
ATOM 979 C TYR 261 16.552 35.310 -1.650 1.00 28.08 A C
ATOM 980 O TYR 261 17.446 34.758 -2.297 1.00 28.35 A O
ATOM 981 N LEU 262 15.522 34.658 -1.126 1.00 27.62 A N
ATOM 982 CA LEU 262 15.363 33.218 -1.241 1.00 28.22 A C
ATOM 983 CB LEU 262 14.202 32.763 -0.352 1.00 28.88 A C
ATOM 984 CG LEU 262 14.318 32.994 1.157 1.00 28.53 A C
ATOM 985 CDl LEU 262 12.982 32.714 1.814 ^ 1.00 28.48 A C
ATOM 986 CD2 LEU 262 15.401 32.101 1.743 ~" 1.00 27.43 A C
ATOM 987 C LEU 262 15.125 32.735 -2.671 1.00 30.45 A C ATOM 988 O LEU 262 15.545 31.646 -3.046 1.00 30.59 A O
ATOM 989 N HIS 2S3 14.436 33.540 -3.464 1.00 30.87 A N
ATOM 990 CA HIS 263 14.137 33.173 -4.842 1.00 30.31 A C
ATOM 991 CB HIS 263 13.001 34.049 -5.363 1.00 27.57 A C
ATOM 992 CG HIS 263 11.688 33.758 -4.717 1.00 24.66 A C
ATOM 993 CD2 HIS 263 11.341 32.829 -3.795 1.00 23.00 A C
ATOM 994 NDl HIS 263 10.525 34.413 -5.059 1.00 22.07 A N
ATOM 995 CEl HIS 263 9.518 33.891 -4.384 1.00 20.48 A C
ATOM 996 NE2 HIS 263 9.986 32.929 -3.611 1.00 18.44 A N
ATOM 997 C HIS 263 15.354 33.296 -5.752 1.00 32.96 A C
ATOM 998 O HIS 263 15.528 32.508 -6.688 1.00 32.86 A O
ATOM 999 N SER. 264 16.180 34.302 -5.470 1.00 35.41 A N
ATOM 1000 CA SER 264 17.399 34.554 -6.226 1.00 35.39 A C
ATOM 1001 CB SER 264 18.048 35.852 -5.757 1.00 35.10 A C
ATOM 1002 OG SER 264 18.410 35.758 -4.388 1.00 38.78 A O
ATOM 1003 C SER 264 18.333 33.390 -5.949 1.00 37.84 A C
ATOM 1004 O SER 264 19.232 33.093 -6.740 1.00 37.53 A O
ATOM 1005 N GLY 265 18.103 32.739 -4.809 1.00 37.87 A N
ATOM 1006 CA GLY 265 18.901 31.595 -4.419 1.00 38.47 A C
ATOM 1007 C GLY 265 18.208 30.296 -4.782 1.00 40.18 A C
ATOM 1008 O GLY 265 18.578 29.228 -4.298 1.00 40.21 A O
ATOM 1009 N LYS 266 17.191 30.397 -5.634 1.00 40.76 A N
ATOM 1010 CA LYS 266 16.431 29.237 -6.097 1.00 41.29 A C
ATOM 1011 CB LYS 266 17.353 28.260 -6.841 1.00 42.20 A C
ATOM 1012 CG LYS 266 17.795 28.731 -8.219 1.00 44.49 A C
ATOM 1013 CD LYS 266 18.961 29.705 -8.146 1.00 49.84 A C
ATOM 1014 CE LYS 266 20.251 28.997 -7.713 1.00 52.53 A C
ATOM 1015 NZ LYS 266 21.415 29.935 -7.579 1.00 55.93 A N
ATOM 1016 C LYS 266 15.688 28.484 -5.006 1.00 39.78 A C
ATOM 1017 O LYS 266 15.514 27.276 -5.101 1.00 40.62 A O
ATOM 1018 N ILE 267 15.225 29.201 -3.987 1.00 40.13 A N
ATOM 1019 CA ILE 267 14.515 28.584 -2.868 1.00 38.77 A C
ATOM 1020 CB ILE 267 15.233 28.898 -1.549 1.00 39.31 A C
ATOM 1021 CG2 ILE 267 14.552 28.181 -0.389 1.00 37.34 A C
ATOM 1022 CGl ILE 267 16.697 28.482 -1.653 1.00 38.32 A C
ATOM 1023 CDl ILE 267 17.508 28.879 -0.453 1.00 41.68 A C
ATOM 1024 C ILE 267 13.062 29.036 -2.731 1.00 39.28 A C
ATOM 1025 O ILE 267 12.775 30.226 -2.723 1.00 39.69 A O
ATOM 1026 N VAL 268 12.142 28.084 -2.635 1.00 38.85 A N
ATOM 1027 CA VAL 268 10.734 28.412 -2.463 1.00 38.33 A C
ATOM 1028 CB VAL 268 9.810 27.468 -3.276 1.00 37.76 A C
ATOM 1029 CGl VAL 268 8.358 27.939 -3.169 1.00 36.45 A C
ATOM 1030 CG2 VAL 268 10.240 27.431 -4.732 1.00 35.09 A C
ATOM 1031 C VAL 268 10.465 28.210 -0.976 1.00 39.22 A C
ATOM 1032 O VAL 268 10.638 27.107 -0.459 1.00 39.27 A O
ATOM 1033 N TYR 269 10.056 29.270 -0.286 1.00 38.12 A N
ATOM 1034 CA TYR 269 9.799 29.177 1.146 1.00 39.13 A C
ATOM 1035 CB TYR 269 9.589 30.566 1.746 1.00 37.65 A C
ATOM 1036 CG TYR 269 9.668 30.542 3.247 1.00 36.42 A C
ATOM 1037 CDl TYR 269 10.851 30.193 3.885 1.00 36.40 A C
ATOM 1038 CEl TYR 269 10.914 30.077 5.256 1.00 34.70 A C
ATOM 1039 CD2 TYR 269 8.550 30.784 4.027 1.00 34.31 A C
ATOM 1040 CE2 TYR 269 8.605 30.672 5.399 1.00 33.35 A C
ATOM 1041 CZ TYR 269 9.788 30.315 6.009 1.00 34.04 A C
ATOM 1042 OH TYR 269 9.849 30.181 7.385 1.00 37.65 A O
ATOM 1043 C TYR 269 8.608 28.287 1.497 1.00 40.39 A C
ATOM 1044 O TYR 269 8.687 27.471 2.410 1.00 40.36 A O
ATOM 1045 N ARG 270 7.497 28.463 0.787 1.00 41.72 A N
ATOM 1046 CA ARG 270 6.306 27.653 1.018 1.00 42.49 A C
ATOM 1047 CB ARG 270 6.654 26.179 0.791 1.00 45.25 A C
ATOM 1048 CG ARG 270 7.132 25.870 -0.613 1.00 50.13 A C
ATOM 1049 CD ARG 270 7.794 24.499 -0.693 1.00 53.38 A C
ATOM 1050 NE ARG 270 6.950 23.446 -0.128 1.00 57.20 A N
ATOM 1051 CZ ARG 270 7.083 22.147 -0.396 1.00 58.00 A C
ATOM 1052 NHl ARG 270 8.027 21.722 -1.230 1.00 57.09 A N
ATOM 1053 NH2 ARG 270 6.269 21.270 0.174 1.00 58.11 A N
ATOM 1054 C ARG 270 5.655 27.802 2.397 1.00 40.47 A C
ATOM 1055 O ARG 270 4.456 27.597 2.541 1.00 39.35 A O
ATOM 1056 N ASP 271 6.438 28.160 3.404 1.00 40.08 A N
ATOM 1057 CA ASP 271 5.926 28.290 4.772 1.00 40.94 A C
ATOM 1058 CB ASP 271 7.014 27.862 5.753 1.00 42.65 A C
ATOM 1059 CG ASP 271 7.013 26.376 6.004 1.00 45.81 A C
ATOM 1060 ODl ASP 271 6.576 25.621 5.105 1.00 47.73 A O ATOM 1061 OD2 ASP 271 .458 25.965 7.100 1.00 47.47 A O
ATOM 1062 C ASP 271 .390 29.655 5.204 1.00 40.64 A C
ATOM 1063 O ASP 271 .120 29.874 6.386 1.00 41.26 A O
ATOM 1064 N LEU 272 .222 30.570 4.262 1.00 38.68 A N
ATOM 1065 CA LEU 272 .739 31.889 4.616 1.00 38.25 A C
ATOM 1066 CB LEU 272 4.880 32.828 3.422 .00 36.75 A C
ATOM 1067 CG LEU 272 4.613 34.274 3.805 .00 33.12 A C
ATOM 1068 CDl LEU 272 5.525 34.628 4.953 .00 33.83 A C
ATOM 1069 CD2 LEU 272 4.836 35.184 2.626 ,00 33.01 A C
ATOM 1070 C LEU 272 3.293 31.906 5.123 ,00 39.27 A C
ATOM 1071 O LEU 111 2.357 31.609 4.388 .00 40.58 A O
ATOM 1072 N LYS 273 3.127 32.266 6.391 ,00 39.40 A N
ATOM 1073 CA LYS 273 1.812 32.350 7.017 .00 38.67 A C
ATOM 1074 CB LYS 273 1.343 30.961 7.457 .00 40.63 A C
ATOM 1075 CG LYS 273 2.198 30.369 8.555 1.00 44.64 A C
ATOM 1076 CD LYS 273 2.159 28.848 8.549 1.00 47.73 A C
ATOM 1077 CE LYS 273 0.788 28.313 8.901 1.00 49.36 A C
ATOM 1078 NZ LYS 273 0.844 26.834 9.038 1.00 51.33 A N
ATOM 1079 C LYS 273 1..951 33.268 8.225 1.00 36.94 A C
ATOM 1080 O LYS 273 3..041 33.434 8.757 1.00 37.77 A O
ATOM 1081 N LEU 274 0..845 33.859 8.659 1.00 36.87 A N
ATOM 1082 CA LEU 274 0..847 34.785 9.790 1.00 35.26 A C
ATOM 1083 CB LEU 274 -0.583 35.231 10.090 1.00 32.89 A C
ATOM 1084 CG LEU 274 -0.771 36.203 11.253 32.28 A C
ATOM 1085 CDl LEU 274 -0.061 37.519 10.957 30.51 A C
ATOM 1086 CD2 LEU 274 -2.274 36.431 11.475 32.96 A C
ATOM 1087 C LEU 274 1.495 34.248 11.064 35.40 A C
ATOM 1088 O LEU 274 2.125 34.996 11.807 36.55 A O
ATOM 1089 N GLU 275 1.339 32.958 11.325 36.40 A N
ATOM 1090 CA GLU 275 1.926 32.373 12.517 36.63 A C
ATOM 1091 CB GLU 275 1.304 31.010 12.808 41.07 A C
ATOM 1092 CG GLU 275 -0.174 31.078 13.144 47.54 A C
ATOM 1093 CD GLU 275 -1.062 30.932 11.926 52.81 A C
ATOM 1094 OEl GLU 275 -0.826 31.632 10.911 53.38 A O
ATOM 1095 OE2 GLU 275 -2.006 30.113 11.993 55.69 A O
ATOM 1096 C GLU 275 3.442 32.234 12.421 1.00 35.05 A C
ATOM 1097 O GLU 275 4.110 32.044 13.432 35.04 A O
ATOM 1098 N ASN 276 3.993 32.333 11.217 34.25 A N
ATOM 1099 CA ASN 276 5.439 32.214 11.058 34.25 A C
ATOM 1100 CB ASN 276 5.781 31.448 9.785 35.68 A C
ATOM 1101 CG ASN 276 5.598 29.959 9.946 39.27 A C
ATOM 1102 ODl ASN 276 6.149 29.356 10.865 41.26 A O
ATOM 1103 ND2 ASN 276 4.824 29.354 9.052 40.98 A N
ATOM 1104 C ASN 276 6.125 33.567 11.033 32.35 A C
ATOM 1105 O ASN 276 7.289 33.676 10.643 31.72 A O
ATOM 1106 N LEU 277 5.398 34.595 11.458 30.38 A N
ATOM 1107 CA LEU 277 5.937 35.948 11.484 28.97 A C
ATOM 1108 CB LEU 277 5.061 36.883 10.670 27.70 A C
ATOM 1109 CG LEU 277 5.014 36.571 9.188 25.25 A C
ATOM 1110 CDl LEU 277 4.038 37.501 8.509 25.03 A C
ATOM 1111 CD2 LEU 277 6.405 36.732 8.614 26.85 A C
ATOM 1112 C LEU 277 6.036 36.489 12.888 29.65 A C
ATOM 1113 O LEU 277 5.093 36.403 13.667 1.00 28.98 A O
ATOM 1114 N MET 278 7.190 37.051 13.207 .00 30.58 A N
ATOM 1115 CA MET 278 7.393 37.627 14.515 .00 32.83 A C
ATOM 1116 CB MET 278 8.308 36.757 15.363 .00 37.26 A C
ATOM 1117 CG MET 278 7.773 35.385 15.678 .00 42.63 A C
ATOM 1118 SD MET 278 8.856 34.623 16.885 .00 48.73 A S
ATOM 1119 CE MET 278 8.321 35.529 18.391 .00 47.56 A C
ATOM 1120 C MET 278 8.038 38.974 14.362 .00 32.62 A C
ATOM 1121 O MET 278 8.418 39.376 13.264 .00 34.36 A O
ATOM 1122 N LEU 279 8.159 39.670 15.482 .00 31.69 A N
ATOM 1123 CA LEU 279 8.795 40.964 15.488 .00 30.36 A C
ATOM 1124 CB LEU 279 7.833 42.032 16.010 .00 28.83 A C
ATOM 1125 CG LEU 279 6.560 42.304 15.199 .00 28.42 A C
ATOM 1126 CDl LEU 279 5.799 43.487 15.812 .00 26.40 A C
ATOM 1127 CD2 LEU 279 6.930 42.607 13.742 .00 25.49 A C
ATOM 1128 C LEU 279 9.993 40.828 16.409 .00 30.29 A C
ATOM 1129 O LEU 279 9.983 40.019 17.331 1.00 29.55 A O
ATOM 1130 N ASP 280 11.040 41.589 16.135 1.00 30.11 A N
ATOM 1131 CA ASP 280 12.215 41.560 16.973 1.00 32.52 A C
ATOM 1132 CB ASP 280 13.486 41.599 16.108 1.00 30.89 A C
ATOM 1133 CG ASP 280 13.588 42.846 15.247 1.00 33.22 A C 26569
ATOM 1134 ODl ASP 280 14.377 42.819 14.281 1.00 32.01 A O
ATOM 1135 OD2 ASP 280 12.907 43.857 15.530 1.00 34.23 A , O
ATOM 1136 C ASP 280 12.126 42.764 17.926 1.00 34.87 A C
ATOM 1137 O ASP 280 11.242 43.614 17.779 1.00 36.98 A O
ATOM 1138 N LYS 281 13.022 42.825 18.906 1.00 35.99 A N
ATOM 1139 CA LYS 281 13.028 43.906 19.884 1.00 36.98 A C
ATOM 1140 CB LYS 281 14.377 43.950 20.598 1.00 38.02 A C
ATOM 1141 CG LYS 281 15.532 44.246 19.659 1.00 41.63 A C
ATOM 1142 CD LYS 281 16.872 44.212 20.353 1.00 42.75 A C
ATOM 1143 CE LYS 281 17.154 42.832 20.905 1.00 45.57 A C
ATOM 1144 NZ LYS 281 18.587 42.693 21.305 1.00 48.79 A N
ATOM 1145 C LYS 281 12.738 45.283 19.285 1.00 37.00 A C
ATOM 1146 O LYS 281 12.047 46.100 19.898 1.00 38.33 A O
ATOM 1147 N ASP 282 13.258 45.546 18.090 1.00 36.74 A N
ATOM 1148 CA ASP 282 13.063 46.851 17.463 1.00 34.73 A C
ATOM 1149 CB ASP 282 14.253 47.182 16.577 1.00 38.13 A C
ATOM 1150 CG ASP 282 15.541 47.262 17.352 1.00 39.98 A C
ATOM 1151 ODl ASP 282 15.618 48.075 18.299 1.00 41.40 A O
ATOM 1152 OD2 ASP 282 16.475 46.511 17.011 1.00 41.64 A O
ATOM 1153 C ASP 282 11.791 47.051 16.658 1.00 33.42 A C
ATOM 1154 O ASP 282 11.480 48.176 16.282 1.00 32.46 A O
ATOM 1155 N GLY 283 11.053 45.980 16.391 1.00 29.89 A N
ATOM 1156 CA GLY 283 9.836 46.131 15.624 1.00 29.20 A C
ATOM 1157 C GLY 283 9.922 45.589 14.208 1.00 29.94 A C
ATOM 1158 O GLY 283 8.921 45.574 13.491 1.00 28.41 A O
ATOM 1159 N HIS 284 11.111 45.146 13.803 1.00 28.84 A N
ATOM 1160 CA HIS 284 11.311 44.573 12.469 1.00 30.20 A C
ATOM 1161 CB HIS 284 12.786 44.619 12.067 1.00 26.21 A C
ATOM 1162 CG HIS 284 13.266 45.996 11.741 1.00 27.91 A C
ATOM 1163 CD2 HIS 284 14.159 46.801 12.362 1.00 27.84 A C
ATOM 1164 NDl HIS 284 12.770 46.722 10.677 1.00 26.13 A N
ATOM 1165 CEl HIS 284 13.339 47.913 10.658 1.00 27.42 A C
ATOM 1166 NE2 HIS 284 14.186 47.987 11.669 1.00 29.81 A N
ATOM 1167 C HIS 284 10.804 43.141 12.394 1.00 31.16 A C
ATOM 1168 O HIS 284 10.799 42.412 13.380 1.00 34.65 A O
ATOM 1169 N ILE 285 10.370 .42.744 11.213 1.00 29.53 A N
ATOM 1170 CA ILE 285 9.846 41.414 11.017 1.00 28.87 A C
ATOM 1171 CB ILE 285 8.986 41.360 9.719 1.00 28.52 A C
ATOM 1172 CG2 ILE 285 9.292 40.092 8.927 1.00 27.97 A C
ATOM 1173 CGl ILE 285 7.505 41.495 10.080 1.00 28.92 A C
ATOM 1174 CDl ILE 285 6.594 40:599 9.285 1.00 26.14 A C
ATOM 1175 C ILE 285 10.922 40.339 10.937 1.00 29.26 A C
ATOM 1176 O ILE 285 12.055 40.591 10.496 1.00 28.33 A O
ATOM 1177 N LYS 286 10.551 39.145 11.389 1.00 29.55 A N
ATOM 1178 CA LYS 286 11.416 37.974 11.336 1.00 30.52 A C
ATOM 1179 CB LYS 286 12.053 37.700 12.690 1.00 32.14 A C
ATOM 1180 CG LYS 286 13.566 37.639 12.656 1.00 36.25 A C
ATOM 1181 CD LYS 286 14.153 39.041 12.659 1.00 40.55 A C
ATOM 1182 CE LYS 286 15.651 39.028 12.953 1.00 41.23 A C
ATOM 1183 NZ LYS 286 16.403 38.237 11.953 1.00 43.28 A N
ATOM 1184 C LYS 286 10.566 36.770 10.922 1.00 30.74 A C
ATOM 1185 O LYS 286 9.617 36.400 11.615 1.00 29.47 A O
ATOM 1186 N ILE 287 10.881 36.189 9.770 1.00 30.06 A N
ATOM 1187 CA ILE 287 10.165 35.012 9.283 1.00 31.21 A C
ATOM 1188 CB ILE 287 10.389 34.823 7.766 1.00 28.65 A C
ATOM 1189 CG2 ILE 287 9.783 33.532 7.288 1.00 27.30 A C
ATOM 1190 CGl ILE 287 9.765 35.984 7.012 1.00 27.84 A C
ATOM 1191 CDl ILE 287 9.831 35.837 5.529 1.00 27.60 A C
ATOM 1192 C ILE 287 10.735 33.822 10.063 1.00 34.35 A C
ATOM 1193 O ILE 287 11.953 33.657 10.138 1.00 32.23 A O
ATOM 1194 N THR 288 9.860 32.996 10.635 1.00 38.21 A N
ATOM 1195 CA THR 288 10.306 31.870 11.455 1.00 44.20 A C
ATOM 1196 CB THR 288 9.835 32.044 12.904 1.00 43.71 A C
ATOM 1197 OGl THR 288 9.854 33.432 13.260 1.00 44.67 A O
ATOM 1198 CG2 THR 288 10.746 31.261 13.838 1.00 45.38 A C
ATOM 1199 C THR 288 9.924 30.441 11.053 1.00 48.12 A C
ATOM 1200 O THR 288 9.078 30.216 10.182 1.00 48.23 A O
ATOM 1201 N ASP 289 10.566 29.493 11.742 1.00 53.41 A N
ATOM 1202 CA ASP 289 10.387 28.045 11.569 1.00 58.67 A C
ATOM 1203 CB ASP 289 11.714 27.314 11.846 1.00 61.68 A C
ATOM 1204 CG ASP 289 11.581 25.787 11.805 1.00 63.27 A C
ATOM 1205 ODl ASP 289 11.902 25.183 10.754 1.00 63.89 A O
ATOM 1206 OD2 ASP 289 11.158 25.194 12.824 1.00 63.63 A O ATOM 1207 C ASP 289 9.344 27.568 12.574 1.00 60.59 A C
ATOM 1208 O ASP 289 8.421 26.818 12.237 1.00 60.64 A O
ATOM 1209 N PHE 290 9.515 27.999 13.819 00 61.93 A N
ATOM 1210 CA PHE 290 8.582 27.637 14.873 00 64.46 A C
ATOM 1211 CB PHE 290 8.403 26.116 14.904 00 65.61 A C
ATOM 1212 CG PHE 290 6.988 25.684 15.151 00 66.36 A C
ATOM 1213 CDl PHE 290 5.958 26.185 14.375 00 66.69 A C
ATOM 1214 CD2 PHE 290 6.684 24.791 16.165 00 66.52 A C
ATOM 1215 CEl PHE 290 4.653 25.806 14.609 00 67.23 A C
ATOM 1216 CE2 PHE 290 5.380 24.410 16.400 00 66.14 A C
ATOM 1217 CZ PHE 290 4.365 24.919 15.621 1.00 66.35 A C
ATOM 1218 C PHE 290 9.043 28.151 16.236 1.00 64.50 A C
ATOM 1219 O PHE 290 8.363 29.039 16.790 1.00 65.28 A O
TER
ATOM 1220 C GLY 308 -0.791 23.872 5.859 00 73.33 A C
ATOM 1221 O GLY 308 -0.861 24.660 4.911 00 73.42 A O
ATOM 1222 N GLY 308 0.466 22.153 4.524 00 73.28 A N
ATOM 1223 CA GLY 308 0.252 22.767 5.870 00 73.30 A C
ATOM 1224 N THR 309 604 23.932 6.913 00 72.65 A N
ATOM 122S CA THR 309 653 24.946 7.035 00 70.83 A C
ATOM 1226 CB THR 309 087 26.266 7.585 00 71.13 A C
ATOM 1227 OGl THR 309 448 26.020 8.844 00 72.12 A O
ATOM 1228 CG2 THR 309 202 27.281 7.783 00 71.08 A C
ATOM 1229 C THR 309 329 25.219 5.697 1.00 68.57 A C
ATOM 1230 O THR 309 862 26.031 4.899 1.00 69.18 A O
ATOM 1231 N PRO 310 •4.453 24.541 5.446 00 66.21 A N
ATOM 1232 CD PRO 310 ■5.065 23.590 6.388 00 65.56 A C
ATOM 1233 CA PRO 310 ■5.251 24.651 4.224 00 64.94 A C
ATOM 1234 CB PRO 310 ■6.461 23.770 4.523 00 65.57 A C
ATOM 1235 CG PRO 310 .912 22.751 5.473 00 65.52 A C
ATOM 1236 C PRO 310 .659 26.073 3.868 00 63.96 A C
ATOM 1237 O PRO 310 .904 26.371 2.699 00 64.19 A O
ATOM 1238 N GLU 311 .735 26.943 4.874 00 63.22 A N
ATOM 1239 CA GLU 311 .132 28.335 4.664 00 60.97 A C
ATOM 1240 CB GLU 311 .229 29.090 5.995 00 61.64 A C
ATOM 1241 CG GLU 311 .088 28.242 7.254 00 62.77 A C
ATOM 1242 CD GLU 311 .308 27.384 7.545 1.00 62.99 A C
ATOM 1243 OEl GLU 311 ■8.443 27..916 7.516 1.00 63.12 A O
ATOM 1244 OE2 GLU 311 ■7.125 26.179 7.818 1.00 63.63 A O
ATOM 1245 C GLU 311 ■5.143 29.067 3.771 1.00 59.21 A C
ATOM 1246 O GLU 311 ■5.499 30.031 3.094 1.00 58.41 A O
ATOM 1247 N TYR 312 ■3.900 28.606 3.770 .00 56.71 A N
ATOM 1248 CA TYR 312 •2.875 29.247 2.965 .00 56.17 A C
ATOM 1249 CB TYR 312 •1.566 29.346 3.767 .00 55.39 A C
ATOM 1250 CG TYR 312 ■1.613 30.366 4.890 .00 54.75 A C
ATOM 1251 CDl TYR 312 •2.341 30.119 6.052 .00 54.34 A C
ATOM 1252 CEl TYR 312 ■2.438 31.070 7.050 .00 53.77 A C
ATOM 1253 CD2 TYR 312 -0.977 31.600 4.762 .00 52.72 A C
ATOM 1254 CE2 TYR 312 -1 072 32.557 5.754 .00 52.55 A C
ATOM 1255 CZ TYR 312 -1 806 32.288 6.895 .00 53.53 A C
ATOM 1256 OH TYR 312 -1 925 33.242 7.881 .00 53.64 A O
ATOM 1257 C TYR 312 -2 598 28.589 1.614 .00 56.01 A C
ATOM 1258 O TYR 312 983 29.204 0.742 .00 58.92 A O
ATOM 1259 N LEU 313 057 27.355 1.427 .00 53.71 A N
ATOM 1260 CA LEU 313 808 26.637 0.179 .00 50.59 A C
ATOM 1261 CB LEU 313 524 25.288 0.190 .00 51.52 A C
ATOM 1262 CG LEU 313 996 24.355 1..280 .00 52.45 A C
ATOM 1263 CDl LEU 313 584 22.965 1..097 .00 52.42 A C
ATOM 1264 CD2 LEU 313 1.474 24.308 1.218 .00 51.98 A C
ATOM 1265 C LEU 313 3.183 27.400 -1.075 .00 47.89 A C
ATOM 1266 O LEU 313 -4 314 27.836 -1.231 .00 48.20 A O
ATOM 1267 N ALA 314 2.211 27.542 -1.969 .00 45.17 A N
ATOM 1268 CA ALA 314 2.399 28.251 -3.224 .00 43.42 A C
ATOM 1269 CB ALA 314 1.038 28.645 -3.802 .00 42.09 A C
ATOM 1270 C ALA 314 163 27.405 -4 231 .00 42.30 A C
ATOM 1271 O ALA 314 143 26.183 ■4.177 .00 42.35 A O
ATOM 1272 N PRO 315 848 28.055 ■5.171 .00 42.14 A N
ATOM 1273 CD PRO 315 050 29.510 ■5.245 .00 42.16 A C
ATOM 1274 CA PRO 315 623 27.369 6.205 1.00 42.75 A C
ATOM 1275 CB PRO 315 019 28.506 -7 133 1.00 40.98 A C
ATOM 1276 CG PRO 315 253 29.624 6.162 1.00 42.50 A C
ATOM 1277 C PRO 315 866 26.256 6.938 1.00 43.93 A C
ATOM 1278 O PRO 315 -4.390 25.150 7.106 1.00 45.33 A O ATOM 1279 N GLU 316 •2.642 26.541 -7.374 00 43.48 A N
ATOM 1280 CA GLU 316 •1.854 25.550 -8.104 00 42.46 A C
ATOM 1281 CB GLU 316 ■0.577 26.179 -8.673 00 40.10 A C
ATOM 1282 CG GLU 316 0.378 26.725 -7.632 00 36.12 A C
ATOM 1283 CD GLU 316 0.186 28.205 -7.381 00 34.49 A C
ATOM 1284 OEl GLU 316 •0.974 28.646 -7.337 00 31.25 A O
ATOM 1285 OE2 GLU 316 1.198 28.922 -7.215 00 34.09 A O
ATOM 1286 C GLU 316 -1 486 24.330 -7.262 00 44.03 A C
ATOM 1287 O GLU 316 ■1.349 23.229 -7.792 00 44.16 A O
ATOM 1288 N VAL 317 •1.315 24.520 -5.959 00 45.34 A N
ATOM 1289 CA VAL 317 ■0.976 23.404 -5.086 00 46.63 A C
ATOM 1290 CB VAL 317 •0.590 23.875 -3.670 00 46.07 A C
ATOM 1291 CGl VAL 317 ■0.705 22.717 -2.692 00 45.67 A C
ATOM 1292 CG2 VAL 317 0.834 24.419 -3.672 00 44.50 A C
ATOM 1293 C VAL 317 ■2.154 22.446 -4.973 00 49.68 A C
ATOM 1294 O VAL 317 ■1.981 21.229 -5.072 00 52.06 A O
ATOM 1295 N LEU 318 •3.350 22.990 -4.770 00 50.65 A N
ATOM 1296 CA LEU 318 ■4.546 22.157 -4.660 00 53.20 A C
ATOM 1297 CB LEU 318 ■5.781 23.025 -4.401 00 50.52 A C
ATOM 1298 CG LEU 318 -5.800 23.782 -3.068 00 48.34 A C
ATOM 1299 CDl LEU 318 -7.095 24.566 -2.935 00 48.60 A C
ATOM 1300 CD2 LEU 318 5.658 22.803 -1.926 00 46.53 A C
ATOM 1301 C LEU 318 4.762 21.323 -5.922 00 55.87 A C
ATOM 1302 O LEU 318 -5 207 20.180 -5.852 00 56.52 A O
ATOM 1303 N GLU 319 •4.443 21.903 -7.075 00 58.92 A N
ATOM 1304 CA GLU 319 ■4.596 21.213 -8.353 00 61.32 A C
ATOM 1305 CB GLU 319 •4.759 22.224 -9.484 00 61.38 A C
ATOM 1306 CG GLU 319 -5 886 23.207 -9.294 00 61.68 A C
ATOM 1307 CD GLU 319 ■6.025 24.132 -10.481 00 63.30 A C
ATOM 1308 OEl GLU 319 ■5.001 24.719 -10.895 00 64.89 A O
ATOM 1309 OE2 GLU 319 •7.152 24.272 -10.999 00 62.89 A O
ATOM 1310 C GLU 319 -3 385 20.335 -8.653 00 63.29 A C
ATOM 1311 O GLU 319 ■3.325 19.676 -9.688 00 62.47 A O
ATOM 1312 N ASP 320 ■2.412 20.353 -7.752 00 66.32 A N
ATOM 1313 CA ASP 320 ■1.206 19.555 -7.913 00 68.85 A C
ATOM 1314 CB ASP 320 •1.552 18.067 -7.805 00 70.20 A C
ATOM 1315 CG ASP 320 ■0.964 17.424 -6.567 00 71.28 A C
ATOM 1316 ODl ASP 320 267 16.234 -6.309 00 72.77 A O
ATOM 1317 OD2 ASP 320 ■0.193 18.111 -5.858 00 71.03 A O
ATOM 1318 C ASP 320 ■0.466 19.806 -9.220 00 69.87 A C
ATOM 1319 O ASP 320 0.442 19.053 -9.566 00 70.87 A O
ATOM 1320 N ASN 321 ■0.842 20.849 -9.953 00 70.86 A N
ATOM 1321 CA ASN 321 •0.157 21.135 -11.211 00 72.35 A C
ATOM 1322 CB ASN 321 ■1.002 22.066 -12.095 00 73.77 A C
ATOM 1323 CG ASN 321 ■0.581 22.022 -13.571 00 75.64 A C
ATOM 1324 ODl ASN 321 •1.204 22.659 -14.426 00 76.33 A O
ATOM 1325 ND2 ASN 321 0.476 21.266 -13.870 00 75.36 A N
ATOM 1326 C ASN 321 1.197 21.779 -10.902 00 72.00 A C
ATOM 1327 O ASN 321 1.475 22.913 -11.307 00 72.45 A O
ATOM 1328 N ASP 322 2.034 21.038 -10.178 00 70.74 A N
ATOM 1329 CA ASP 322 3.360 21.506 -9.783 00 69.11 A C
ATOM 1330 CB ASP 322 4.224 21.777 -11.025 00 71.01 A C
ATOM 1331 CG ASP 322 4.683 20.489 -11.713 00 72.69 A C
ATOM 1332 ODl ASP 322 5.297 20.579 -12.799 00 73.50 A O
ATOM 1333 OD2 ASP 322 4.435 19.388 -11.168 00 72.53 A O
ATOM 1334 C ASP 322 3.256 22.757 -8.910 00 66.60 A C
ATOM 1335 O ASP 322 436 22.794 -7.988 1.00 66.84 A O
ATOM 1336 N TYR 323 077 23.766 -9.199 1.00 62.24 A N
ATOM 1337 CA TYR 323 086 25.009 -8.429 1.00 58.36 A C
ATOM 1338 CB TYR 323 353 24.819 -7.106 1.00 58.48 A C
ATOM 1339 CG TYR 323 257 24.303 -6.018 1.00 59.21 A C
ATOM 1340 CDl TYR 323 201 25.134 -5.433 60.57 A C
ATOM 1341 CEl TYR 323 062 24.672 -4.469 61.83 A C
ATOM 1342 CD2 TYR 323 4.200 22.983 -5.601 59.87 A C
ATOM 1343 CE2 TYR 323 5.060 22.509 -4.631 61.13 A C
ATOM 1344 CZ TYR 323 5.991 23.361 -4.069 62.30 A C
ATOM 1345 OH TYR 323 6.863 22.912 -3.104 64.04 A O
ATOM 1346 C TYR 323 5.532 25.419 -8.122 55.83 A C
ATOM 1347 O TYR 323 6.435 24.583 -8.096 55.74 A O
ATOM 1348 N GLY 324 5.747 26.704 -7.862 52.24 A N
ATOM 1349 CA GLY 324 7.092 27.167 -7.564 45.65 A C
ATOM 1350 C GLY 324 7.127 28.408 -6.696 41.13 A C
ATOM 1351 O GLY 324 6.271 28.600 -5.827 1.00 40.39 A O ATOM 1352 N ARG 325 8.115 29.259 -6.946 1.00 36.85 A N
ATOM 1353 CA ARG 325 8.293 30.486 -6.192 1.00 33.18 A C
ATOM 1354 CB ARG 325 9.419 31.316 -6.810 1.00 33.34 A C
ATOM 1355 CG ARG 325 9.231 31.636 -8.275 1.00 33.22 A C
ATOM 1356 CD ARG 325 10.420 32.421 -8.827 1.00 35.22 A C
ATOM 1357 NE ARG 325 10.326 32.545 -10.274 1.00 36.17 A N
ATOM 1358 CZ ARG 325 9.566 33.432 -10.907 1.00 37.74 A C
ATOM 1359 NHl ARG 325 8.838 34.307 -10.224 1.00 38.08 A N
ATOM 1360 NH2 ARG 325 9.483 33.399 -12.230 1.00 38.34 A N
ATOM 1361 C ARG 325 7.033 31.339 -6.069 1.00 30.81 A C
ATOM 1362 O ARG 325 6.857 32.051 -5.084 1.00 29.77 A O
ATOM 1363 N ALA 326 6.153 31.265 -7.059 1.00 29.84 A N
ATOM 1364 CA AIiA 326 4.929 32.049 -7.032 1.00 28.14 A C
ATOM 1365 CB ALA 326 4.168 31.866 -8.321 1.00 26.63 A C
ATOM 1366 C ALA 326 4.023 31.737 -5.846 1.00 30.40 A C
ATOM 1367 O ALA 326 3.195 32.569 -5.481 1.00 32.67 A O
ATOM 1368 N VAL 327 4.156 30.554 -5.240 1.00 30.39 A N
ATOM 1369 CA VAL 327 3.302 30.234 -4.099 1.00 29.86 A C
ATOM 1370 CB VAL 327 3.454 28.755 -3.601 1.00 31.48 A C
ATOM 1371 CGl VAL 327 3.106 27.792 -4.715 1.00 30.17 A C
ATOM 1372 CG2 VAL 327 4.850 28.513 -3.061 1.00 26.79 A C
ATOM 1373 C VAL 327 3.621 31.168 -2.937 1.00 30.12 A C
ATOM 1374 O VAL 327 2.738 31.487 -2.133 1.00 32.73 A O
ATOM 1375 N ASP 328 4.876 31.605 -2.843 1.00 26.78 A N
ATOM 1376 CA ASP 328 5.267 32.513 -1.776 1.00 25.56 A C
ATOM 1377 CB ASP 328 6.780 32.757 -1.759 1.00 23.71 A C
ATOM 1378 CG ASP 328 7.569 31.551 -1.291 1.00 25.16 A C
ATOM 1379 ODl ASP 328 6.999 30.689 -0.574 1.00 22.56 A O
ATOM 1380 OD2 ASP 328 8.776 31.487 -1.630 1.00 25.00 A O
ATOM 1381 C ASP 328 4.558 33.851 -1.954 1.00 24.81 A C
ATOM 1382 O ASP 328 4.197 34.500 -0.976 1.00 24.56 A O
ATOM 1383 N TRP 329 4.371 34.278 -3.197 1.00 23.29 A N
ATOM 1384 CA TRP 329 3.688 35.540 -3.418 1.00 24.55 A C
ATOM 1385 CB TRP 329 3.800 35.957 -4.875 1.00 23.84 A C
ATOM 1386 CG TRP 329 5.213 36.149 -5,252 1.00 25.03 A C
ATOM 1387 CD2 TRP 329 6.208 36.859 -4.501 1.00 23.83 A C
ATOM 1388 CE2 TRP 329 7.415 36.764 -5.217 1.00 22.98 A C
ATOM 1389 CE3 TRP 329 6.193 37.566 -3.293 1.00 23.99 A C
ATOM 1390 CDl TRP 329 5.837 35.668 -6.359 1.00 24.11 A C
ATOM 1391 NEl TRP 329 7.163 36.033 -6.348 1.00 26.28 A N
ATOM 1392 CZ2 TRP 329 8.597 37.346 -4.768 1.00 24.88 A C
ATOM 1393 CZ3 TRP 329 7.368 38.145 -2.845 1.00 24.65 A C
ATOM 1394 CH2 TRP 329 8.554 38.031 -3.582 1.00 25.06 A C
ATOM 1395 C TRP 329 2.242 35.355 -3.007 1.00 25.85 A C
ATOM 1396 O TRP 329 1.681 36.209 -2.325 1.00 25.79 A O
ATOM 1397 N TRP 330 1.641 34.233 -3.400 1.00 24.90 A N
ATOM 1398 CA TRP 330 0.264 33.973 -3.002 1.00 26.13 A C
ATOM 1399 CB TRP 330 -0.179 32.597 -3.470 1.00 24.23 A C
ATOM 1400 CG TRP 330 -1.452 32.161 -2.849 1.00 24.34 A C
ATOM 1401 CD2 TRP 330 -2.771 32.299 -3.400 1.00 23.94 A C
ATOM 1402 CE2 TRP 330 -3.673 31.767 -2.460 1.00 24.03 A C
ATOM 1403 CE3 TRP 330 -3.275 32.822 -4.597 1.00 19.48 A C
ATOM' 1404 CDl TRP 330 -1.605 31.568 -1.632 1.00 23.98 A C
ATOM 1405 NEl TRP 330 -2.937 31.326 -1.390 1.00 26.79 A N
ATOM 1406 CZ2 TRP 330 -5.048 31.743 -2.679 1.00 23.66 A C
ATOM 1407 CZ3 TRP 330 -4.631 32.797 -4.810 1.00 21.04 A C
ATOM 1408 CH2 TRP 330 -5.506 32.262 -3.858 1.00 22.72 A C
ATOM 1409 C TRP 330 0.218 34.043 -1.473 1.00 26.40 A C
ATOM 1410 O TRP 330 -0.704 34.623 -0.884 1.00 26.25 A O
ATOM 1411 N GLY 331 1.231 33.456 -0.844 1.00 23.24 A N
ATOM 1412 CA GLY 331 1.328 33.479 0.604 1.00 20.88 A C
ATOM 1413 C GLY 331 1.477 34.891 1.130 1.00 20.06 A C
ATOM 1414 O GLY 331 1.041 35.183 2.229 1.00 20.04 A O
ATOM 1415 N LEU 332 2.096 35.779 0.361 1.00 20.49 A N
ATOM 1416 CA LEU 332 2.244 37.158 0.812 1.00 21.62 A C
ATOM 1417 CB LEU 332 3.233 37.925 -0.074 1.00 21.25 A C
ATOM 1418 CG LEU 332 3.399 39.420 0.219 1.00 20.55 A C
ATOM 1419 CDl LEU 332 4.134 39.623 1.524 1.00 22.75 A C
ATOM 1420 CD2 LEU 332 4.167 40.069 -0.907 1.00 22.40 A C
ATOM 1421 C LEU 332 0.874 37.835 0.760 1.00 21.19 A C
ATOM 1422 O LEU 332 0.532 38.619 1.631 1.00 22.39 A O
ATOM 1423 N GLY 333 0.097 37.518 -0.270 1.00 22.36 A N
ATOM 1424 CA GLY 333 -1.230 38.085 -0.411 1.00 21.98 A C ATOM 1425 C GLY 333 -2.111 37.734 0.777 1.00 24.30 A C
ATOM 1426 O GLY 333 -2.813 38.589 1.318 1.00 24.35 A O
ATOM 1427 N VAL 334 -2.064 36.476 1.201 1.00 23.82 A N
ATOM 1428 CA VAL 334 -2.881 36.039 2.322 1.00 24.19 A C
ATOM 1429 CB VAL 334 -2.709 34.523 2.594 1.00 27.46 A C
ATOM 1430 CGl VAL 334 -3.552 34.118 3.821 1.00 24.35 A C
ATOM 1431 CG2 VAL 334 -3.115 33.707 1.344 1.00 20.46 A C
ATOM 1432 C VAL 334 -2.576 36.817 3.604 1.00 24.10 A C
ATOM 1433 O VAL 334 -3.497 37.340 4.239 1.00 23.68 A O
ATOM 1434 N VAL 335 -1.294 36.901 3.979 1.00 23.44 A N
ATOM 1435 CA VAL 335 -0.906 37.631 5.182 1.00 22.94 A C
ATOM 1436 CB VAL 335 0.596 37.428 5.555 1.00 23.54 A C
ATOM 1437 CGl VAL 335 0.880 35.963 5.811 1.00 27.53 A C
ATOM 1438 CG2 VAL 335 1.490 37.960 4.461 1.00 25.14 A C
ATOM 1439 C VAL 335 -1.164 39.137 5.074 1.00 24.35 A C
ATOM 1440 O VAL 335 -1.614 39.762 6.035 1.00 25.04 A O
ATOM 1441 N MET 336 -0.890 39.732 3.920 1.00 21.77 A N
ATOM 1442 CA MET 336 -1,127 41.160 3.803 1.00 24.11 A C
ATOM 1443 CB MET 336 -0,451 41.738 2.553 1.00 23.07 A C
ATOM 1444 CG MET 336 1.065 41.796 2.683 1.00 24.29 A C
ATOM 1445 SD MET 336 1.918 42.678 1.362 1.00 19.92 A S
ATOM 1446 CE MET 336 1.730 44.331 1.906 1.00 23.86 A C
ATOM 1447 C MET 336 -2.619 41.434 3.783 1.00 25.44 A C
ATOM 1448 O MET 336 -3.070 42.468 4.281 1.00 27.04 A O
ATOM 1449 N TYR 337 -3.386 40.507 3.216 1.00 26.88 A N
ATOM 1450 CA TYR 337 -4.836 40.668 3.166 1.00 29,41 A C
ATOM 1451 CB TYR 337 -5.480 39.556 2.338 1.00 30.68 A C
ATOM 1452 CG TYR 337 -6.994 39.620 2.326 1.00 30.92 A C
ATOM 1453 CDl TYR 337 -7.743 39.203 3.429 1.00 32.20 A C
ATOM 1454 CEl TYR 337 -9.127 39.288 3.425 1.00 29.49 A C
ATOM 1455 CD2 TYR 337 -7.674 40.123 1.224 1.00 29.48 A C
ATOM 1456 CE2 TYR 337 -9.044 40.213 1.211 1.00 29.08 A C
ATOM 1457 CZ TYR 337 -9.772 39.795 2.310 1.00 30.98 A C
ATOM 1458 OH TYR 337 11.143 39.901 2.281 1.00 25.46 A O
ATOM 1459 C TYR 337 -5.357 40.593 4.586 1.00 30.24 A C
ATOM 1460 O TYR 337 -6.157 41.411 5.015 1.00 31.82 A O
ATOM 1461 N GLU 338 -4.874 39.605 5.317 1.00 31.60 A N
ATOM 1462 CA GLU 338 -5.280 39.402 6.689 1.00 32.63 A C
ATOM 1463 CB GLU 338 -4.670 38.098 7.178 1.00 35.25 A C
ATOM 1464 CG GLU 338 -4.944 37.739 8.613 1.00 41.43 A C
ATOM 1465 CD GLU 338 -4.698 36.256 8.878 1.00 45.40 A C
ATOM 1466 OEl GLU 338 -3.736 35.691 8.295 1.00 43.84 A O
ATOM 1467 OE2 GLU 338 -5.470 35.663 9.670 1.00 45.48 A O
ATOM 1468 C GLU 338 -4.895 40.569 7,592 1.00 32.10 A C
ATOM 1469 O GLU 338 -5.590 40.873 8,554 1.00 34.23 A O
ATOM 1470 N MET 339 -3.797 41.240 7.286 1.00 31.42 A N
ATOM 1471 CA MET 339 -3.375 42.360 8.109 1.00 30.19 A C
ATOM 1472 CB MET 339 -1.914 42.706 7.827 1.00 29.17 A C
ATOM 1473 CG MET 339 -0.930 41.668 8.332 1.00 30.03 A C
ATOM 1474 SD MET 339 0.775 42.040 7.900 1.00 29.17 A S
ATOM 1475 CE MET 339 1.573 40.729 8.739 1.00 32.20 A C
ATOM 1476 C MET 339 -4.230 43.604 7.919 1.00 30.89 A C
ATOM 1477 O MET 339 -4.611 44.255 8.891 1.00 32.58 A O
ATOM 1478 N MET 340 -4.527 43.933 6.666 1.00 30.42 A M
ATOM 1479 CA MET 340 -5.315 45.118 6.353 1.00 31.77 A C
ATOM 1480 CB MET 340 -5.008 45.610 4.938 1.00 31.54 A C
ATOM 1481 CG MET 340 -3.626 46.207 4.739 1.00 31.90 A C
ATOM 1482 SD MET 340 -3.442 46.870 3.052 1.00 32.99 A S
ATOM 1483 CE MET 340 -2.800 45.501 2.210 1.00 32.35 A C
ATOM 1484 C MET 340 -6.815 44.915 6.469 1.00 32.50 A C
ATOM 1485 O MET 340 -7.555 45.886 6.601 1.00 32.88 A O
ATOM 1486 N CYS 341 -7.270 43.665 6.409 1.00 32.18 A N
ATOM 1487 CA CYS 341 -8.697 43.382 6.490 1.00 32.16 A C
ATOM 1488 CB CYS 341 -9.118 42.446 5.365 1.00 28.71 A C
ATOM 1489 SG CYS 341 -8.804 43.086 3.732 1.00 33.34 A S
ATOM 1490 C CYS 341 -9.095 42.769 7.814 1.00 34.31 A C
ATOM 1491 O CYS 341 10.276 42.711 8.143 1.00 36.55 A O
ATOM 1492 N GLY 342 -8.112 42.304 8.572 1.00 35.15 A N
ATOM 1493 CA GLY 342 -8.409 41.693 9.854 1.00 36.55 A C
ATOM 1494 C GLY 342 -9.048 40.317 9.753 1.00 38.09 A C
ATOM 1495 O GLY 342 -9.417 39.731 10.762 1.00 38.99 A O
ATOM 1496 N ARG 343 -9.175 39.793 8.541 1.00 39.24 A N
ATOM 1497 CA ARG 343 -9.783 38.482 8.342 1.00 41.14 A C ATOM 1498 CB ARG 343 -11.287 38.638 8.045 1.00 42.46 A C
ATOM 1499 CG ARG 343 -11.629 39.034 6.596 1.00 46.66 A C
ATOM 1500 CD ARG 343 -13.134 39.338 6.397 1.00 49.57 A C
ATOM 1501 NE ARG 343 -13.471 40.744 6.660 1.00 55.03 A N
ATOM 1502 CZ ARG 343 -13.552 41.708 5.732 1.00 55.54 A C
ATOM 1503 NHl ARG 343 -13.329 41.443 4.444 1.00 53.65 A N
ATOM 1504 NH2 ARG 343 -13.849 42.955 6.095 1.00 55.00 A N
ATOM 1505 C ARG 343 -9.090 37.773 7.177 1.00 40.24 A C
ATOM 1506 O ARG 343 -8.446 38.420 6.351 1.00 39.72 A O
ATOM 1507 N LEU 344 -9.216 36.449 7.122 1.00 39.17 A N
ATOM 1508 CA IiEU 344 -8.616 35.661 6.048 1.00 40.46 A C
ATOM 1509 CB LEU 344 -8.697 34.165 6.366 1.00 39.53 A C
ATOM 1510 CG LEU 344 -7.720 33.578 7.381 1.00 40.76 A C
ATOM 1511 CDl LEU 344 -8.038 32.105 7.592 1.00 40.37 A C
ATOM 1512 CD2 LEU 344 -6.288 33.748 6.891 1.00 39.34 A C
ATOM 1513 C LEU 344 -9.315 35.923 4.715 1.00 40.96 A C
ATOM 1514 O LEU 344 -10.474 36.321 4.683 1.00 42.93 A O
ATOM 1515 N PRO 345 -8.608 35.722 3.596 1.00 41.10 A N
ATOM 1516 CD PRO 345 -7.159 35.499 3.465 1.00 40.88 A C
ATOM 1517 CA PRO 345 -9.224 35.950 2.287 1.00 43.77 A C
ATOM 1518 CB PRO 345 -8.022 36.017 1.348 1.00 40.70 A C
ATOM 1519 CG PRO 345 -7.026 35.133 2.008 1.00 40.43 A C
ATOM 1520 C PRO 345 -10.201 34.829 1.921 1.00 46.87 A C
ATOM 1521 O PRO 345 -11.130 35.030 1.136 1.00 46.38 A O
ATOM 1522 N PHE 346 -9.984 33.653 2.506 1.00 50.52 A N
ATOM 1523 CA PHE 346 -10.837 32.488 2.263 1.00 53.75 A C
ATOM 1524 CB PHE 346 -10.226 31.592 1.184 1.00 52.77 A C
ATOM 1525 CG PHE 346 -9.882 32.311 -0.086 1.00 51.39 A C
ATOM 1526 CDl PHE 346 -10.870 32.858 -0.880 1.00 50.11 A C
ATOM 1527 CD2 PHE 346 -8.565 32.423 -0.493 1.00 51.25 A C
ATOM 1528 CEl PHE 346 -10.550 33.499 -2.056 1.00 50.20 A C
ATOM 1529 CE2 PHE 346 -8.244 33.063 -1.668 1.00 49.90 A C
ATOM 1530 CZ PHE 346 -9.237 33.600 -2.451 1.00 50.45 A C
ATOM 1531 C PHE 346 -10.977 31.669 3.545 1.00 56.49 A C
ATOM 1532 O PHE 346 -9.974 31.272 4.148 1.00 55.68 A O
ATOM 1533 N TYR 347 -12.212 31.423 3.971 1.00 59.74 A N
ATOM 1534 CA TYR 347 -12.428 30.624 5.171 1.00 62.99 A C
ATOM 1535 CB TYR 347 -12.321 31.464 6.444 1.00 65.30 A C
ATOM 1536 CG TYR 347 -12.505 30.611 7.683 1.00 68.12 A C
ATOM 1537 CDl TYR 347 -11.572 29.635 8.020 1.00 69.28 A C
ATOM 1538 CEl TYR 347 -11.767 28.799 9.115 1.00 70.05 A C
ATOM 1539 CD2 TYR 347 -13.642 30.732 8.481 1.00 68.73 A C
ATOM 1540 CE2 TYR 347 -13.846 29.899 9.578 1.00 69.19 A C
ATOM 1541 CZ TYR 347 -12.906 28.935 9.887 1.00 69.88 A C
ATOM 1542 OH TYR 347 -13.105 28.091 10.957 1.00 71.43 A O
ATOM 1543 C TYR 347 -13.748 29.879 5.214 1.00 63.86 A C
ATOM 1544 O TYR 347 -14.785 30.386 4.785 1.00 62.63 A O
ATOM 1545 N ASN 348 -13.682 28.667 5.759 1.00 66.23 A N
ATOM 1546 CA ASN 348 -14.832 27.786 5.912 1.00 68.57 A C
ATOM 1547 CB ASN 348 -15.353 27.336 4.549 1.00 69.07 A C
ATOM 1548 CG ASN 348 -16.669 26.598 4.651 1.00 70.76 A C
ATOM 1549 ODl ASN 348 -17.688 27.171 5.042 1.00 70.09 A O
ATOM 1550 ND2 ASN 348 -16.655 25.316 4.307 1.00 71.65 A N
ATOM 1551 C ASN 348 -14.354 26.577 6.704 1.00 69.59 A C
ATOM 1552 O ASN 348 -13.210 26.152 6.549 1.00 69.03 A O
ATOM 1553 N GLN 349 -15.217 26.023 7.551 1.00 71.11 A N
ATOM 1554 CA GLN 349 -14.824 24.871 8.357 1.00 72.91 A C
ATOM 1555 CB GLN 349 -15.853 24.591 9.455 1.00 75.46 A C
ATOM 1556 CG GLN 349 -17.105 23.874 8.981 1.00 78.34 A C
ATOM 1557 CD GLN 349 -17.868 23.241 10.131 1.00 80.69 A C
ATOM 1558 OEl GLN 349 -18.914 22.615 9.930 1.00 82.26 A O
ATOM 1559 NE2 GLN 349 -17.344 23.396 11.347 1.00 80.69 A N
ATOM 1560 C GLN 349 -14.654 23.630 7.493 1.00 72.76 A C
ATOM 1561 O GLN 349 -13.743 22.834 7.712 1.00 72.16 A O
ATOM 1562 N ASP 350 -15.535 23.461 6.514 1.00 73.51 A N
ATOM 1563 CA ASP 350 -15.441 22.316 5.619 1.00 73.78 A C
ATOM 1564 CB ASP 350 -16.806 21.973 5.026 1.00 74.28 A C
ATOM 1565 CG ASP 350 -16.716 20.910 3.952 1.00 74.83 A C
ATOM 1566 ODl ASP 350 -16.031 19.893 4.187 1.00 75.35 A O
ATOM 1567 OD2 ASP 350 -17.329 21.087 2.879 1.00 75.08 A O
ATOM 1568 C ASP 350 -14.461 22.653 4.504 1.00 73.81 A C
ATOM 1569 O ASP 350 -14.767 23.433 3.602 1.00 73.95 A O
ATOM 1570 N HIS 351 -13.280 22.058 4.574 1.00 73.87 A N ATOM 1571 CA HIS 351 -12.248 22.315 590 00 74.20 A C
ATOM 1572 CB HIS 351 -11.041 21.436 879 0074.72 A C
ATOM 1573 CG HIS 351 -10.478 21.655 5.245 00 75.78 A C
ATOM 1574 CD2 HIS 351 -9.340 22.263 5.656 00 76.51 A C
ATOM 1575 NDl HIS 351 -11.156 21.299 6.391 00 76.31 A N
ATOM 1576 CEl HIS 351 -10.462 21.680 7.448 00 76.82 A C
ATOM 1577 NE2 HIS 351 -9.356 22.269 7.030 00 76.56 A N
ATOM 1578 C HIS 351 -12.711 22.155 2.159 00 73.89 A C
ATOM 1579 O HIS 351 -12.495 23.045 1.347 00 75.86 A O
ATOM 1580 N GLU 352 -13.348 21.041 1.831 00 73.55 A N
ATOM 1581 CA GLU 352 -13.819 20.869 0.463 00 73.29 A C
ATOM 1582 CB GLU 352 -14.737 19.651 0.359 00 73.98 A C
ATOM 1583 CG GLU 352 -15.425 19.515 -0.986 00 74.83 A C
ATOM 1584 CD GLU 352 -16.272 18.265 -1.079 00 75.64 A C
ATOM 1585 OEl GLU 352 -17.021 18.125 -2.070 00 76.76 A O
ATOM 1586 OE2 GLU 352 -16.183 17.420 -0.163 00 75.56 A O
ATOM 1587 C GLU 352 -14.578 22.130 0.040 00 72.35 A C
ATOM 1588 O GLU 352 -14.506 22.559 -1.113 00 72.38 A O
ATOM 1589 N LYS 353 -15.301 22.720 0.986 00 70.56 A N
ATOM 1590 CA LYS 353 -16.063 23.936 0.727 00 68.53 A C
ATOM 1591 CB LYS 353 -17.098 24.145 1.833 00 69.11 A C
ATOM 1592 CG LYS 353 -18.110 25.243 1.560 00 70.36 A C
ATOM 1593 CD LYS 353 -19.062 25.414 2.742 00 71.43 A C
ATOM 1594 CE LYS 353 -19.789 24.114 3.090 00 72.14 A C
ATOM 1595 NZ LYS 353 -20.672 23.635 1.987 00 71.79 A N
ATOM 1596 C LYS 353 -15.091 25.110 0.697 00 66.83 A C
ATOM 1597 O LYS 353 -15.309 26.100 -0.001 00 66.66 A O
ATOM 1598 N LEU 354 -14.015 24.980 1.468 00 64.26 A N
ATOM 1599 CA LEU 354 -12.978 26.001 1.561 00 62.15 A C
ATOM 1600 CB LEU 354 -12.104 25.736 2.788 00 62.56 A C
ATOM 1601 CG LEU 354 -10.951 26.695 3.086 00 63.07 A C
ATOM 1602 CDl LEU 354 -10.218 26.221 4.332 00 63.73 A C
ATOM 1603 CD2 LEU 354 -9.998 26.750 1.909 00 63.30 A C
ATOM 1604 C LEU 354 -12.119 25.979 0.304 00 60.74 A C
ATOM 1605 O LEU 354 -11.763 27.022 -0.241 00 59.04 A O
ATOM 1606 N PHE 355 -11.786 24.775 -0 143 00 59.90 A N
ATOM 1607 CA PHE 355 -10.980 24.594 ■1.332 00 59.06 A C
ATOM 1608 CB PHE 355 -10.597 23.122 ■1.495 00 60.04 A C
ATOM 1609 CG PHE 355 -9.619 22.633 •0.458 00 61.61 A C
ATOM 1610 CDl PHE 355 -8.598 23.458 ■0.005 00 61.82 A C
ATOM 1611 CD2 PHE 355 -9..705 21.347 0.049 00 63.25 A C
ATOM 1612 CEl PHE 355 -7..680 23.012 0.936 00 62.74 A C
ATOM 1613 CE2 PHE 355 -8.790 20.892 0.990 00 62.99 A C
ATOM 1614 CZ PHE 355 -7.775 21.729 1.434 00 62.86 A C
ATOM 1615 C PHE 355 -11.747 25.074 •2.553 00 59.15 A C
ATOM 1616 O PHE 355 -11.149 25.401 •3.576 00 59.04 A O
ATOM 1617 N GLU 356 -13.073 25.114 •2.443 0058.19 A N
ATOM 1618 CA GLU 356 -13.911 25.578 ■3.543 00 57.63 A C
ATOM 1619 CB GLU 356 -15.390 25.289 ■3.256 00 60.27 A C
ATOM 1620 CG GLU 356 -15.754 23.814 -3 258 00 64.60 A C
ATOM 1621 CD GLU 356 -16.648 23.427 ■4.432 00 67.09 A C
ATOM 1622 OEl GLU 356 -16.311 23.777 ■5.586 00 67.88 A O
ATOM 1623 OE2 GLU 356 -17.686 22.765 ■4.200 0068.55 A O
ATOM 1624 C GLU 356 -13.706 27.079 -3 660 00 55.20 A C
ATOM 1625 O GLU 356 -13.766 27.652 ■4.749 00 53.24 A O
ATOM 1626 N LEU 357 -13.457 27.702 2.513 00 52.94 A N
ATOM 1627 CA LEU 357 -13.251 29.138 ■2.429 0052.59 A C
ATOM 1628 CB LEU 357 -13.351 29.566 0.970 00 52.69 A C
ATOM 1629 CG LEU 357 -14.648 29.055 0.335 0053.51 A C
ATOM 1630 CDl LEU 357 -14.623 29.283 1.159 00 54.39 A C
ATOM 1631 CD2 LEU 357 -15.843 29.748 0.978 00 53.94 A C
ATOM 1632 C LEU 357 -11.907 29.555 3.018 00 52.08 A C
ATOM 1633 O LEU 357 -11.846 30.398 3.912 00 52.22 A O
ATOM 1634 N ILE 358 -10.834 28.955 -2.521 00 51.11 A N
ATOM 1635 CA ILE 358 -9.495 29.259 -3.005 00 51.22 A C
ATOM 1636 CB ILE 358 -8.455 28.362 -2.303 00 49.50 A C
ATOM 1637 CG2 ILE 358 -7.067 28.651 -2.835 0049.85 A C
ATOM 1638 CGl ILE 358 -8.501 28.605 -0.794 00 49.13 A C
ATOM 1639 CDl ILE 358 -7.561 27.721 -0.003 0048.72 A C
ATOM 1640 C ILE 358 -9.384 29.066 -4.520 00 52.59 A C
ATOM 1641 O ILE 358 -8.833 29.906 -5.226 00 52.09 A O
ATOM 1642 N LEU 359 -9.931 27.959 -5.011 00 55.56 A N
ATOM 1643 CA LEU 359 -9.891 27.621 -6.431 1.00 56.97 A C ATOM 1644 CB LEU 359 -10.335 26.171 ■6.622 1.00 56.17 A C
ATOM 1645 CG LEU 359 -9.432 25.136 5.940 1.00 56.50 A C
ATOM 164S CDl LEU 359 -10.100 23.775 ■5.963 1.00 56.55 A C
ATOM 1647 CD2 LEU 359 -8.092 25.083 6.637 1.00 55.45 A C
ATOM 1648 C LEU 359 -10.725 28.540 ■7.315 1.00 58.29 A C
ATOM 1649 O LEU 359 -10.279 28.936 ■8.393 1.00 59.80 A O
ATOM 16S0 M MET 360 -11.934 28.870 6.874 ,00 59.55 A N
ATOM 1651 CA MET 360 -12.801 29.765 ■7.641 .00 61.68 A C
ATOM-. 1652 CB MET 360 -13.692 28.990 8.613 .00 64.40 A C
ATOM 1653 CG MET 360 -12.952 28.111 ■9.594 .00 66.73 A C
ATOM 1654 SD MET 360 -13.493 26.430 9.332 ,00 70.82 A S
ATOM 1655 CE MET 360 -13.273 26.319 ■7.537 .00 68.19 A C
ATOM 165S C MET 360 -13.684 30.564 6.707 .00 61.16 A C
ATOM 1657 O MET 360 -14.618 30.034 ■6.109 .00 62.04 A O
ATOM 1658 N GLU 361 -13.382 31.845 6.589 .00 60.50 A N
ATOM 1659 CA GLU 361 -14.138 32.727 •5.722 .00 60.49 A C
ATOM 1660 CB GLU 361 -14.326 32.088 ■4.343 .00 62.17 A C
ATOM 1661 CG GLU 361 -15.265 32.849 •3.397 .00 65.76 A C
ATOM 1662 CD GLU 361 -16.747 32.698 •3.751 .00 68.17 A C
ATOM 1663 OEl GLU 361 -17.074 31.929 ■4.687 .00 68.46 A O
ATOM 1664 OE2 GLU 361 -17.588 33.348 3.083 .00 68.88 A O
ATOM 1665 C GLU 361 -13.338 34.008 ■5.593 .00 58.89 A C
ATOM 1666 O GLU 361 -12.310 34.042 •4.918 .00 58.85 A O
ATOM 1667 N ASP 362 -13.800 35.052 ■6.271 .00 57.47 A N
ATOM 1668 CA ASP 362 -13.135 36.340 ■6.227 .00 54.83 A C
ATOM 1669 CB ASP 362 -13.914 37.360 7.057 .00 56.50 A C
ATOM 1670 CG ASP 362 -13.969 36.995 •8.530 .00 57.78 A C
ATOM 1671 ODl ASP 362 -14.774 37.611 ■9.262 .00 59.40 A O
ATOM 1672 OD2 ASP 362 -13.202 36.105 •8.962 .00 57.25 A O
ATOM 1673 C ASP 362 -13.104 36.780 ■4.777 .00 53.41 A C
ATOM 1674 O ASP 362 -14.021 36.471 •4.013 .00 50.97 A O
ATOM 1675 N ILE 363 -12.044 37.483 •4.394 .00 52.06 A N
ATOM 1676 CA ILE 363 -11.932 37.971 ■3.030 .00 51.66 A C
ATOM 1677 CB ILE 363 -10.'467 38.266 •2.625 .00 52.11 A C
ATOM 1678 CG2 ILE 363 -9.819 37.018 ■2.064 .00 53.10 A C
ATOM 1679 CGl ILE 363 -9.691 38.824 •3.819 .00 52.11 A C
ATOM 1680 CDl ILE 363 -10.260 40.112 ■4.364 1.00 54.16 A C
ATOM 1681 C ILE 363 -12.718 39.256 •2.888 1.00 50.78 A C
ATOM 1682 O ILE 363 -13.027 39.926 •3.875 1.00 51.12 A O
ATOM 1683 N LYS 364 -13.056 39.590 ■1.653 1.00 49.02 A N
ATOM 1684 CA LYS 364 -13.777 40.817 ■1.395 1.00 48.69 A C
ATOM 1685 CB LYS 364 -15.111 40.520 ■0.712 1.00 50.96 A C
ATOM 1686 CG LYS 364 -16.052 39.713 -1 587 1.00 55.40 A C
ATOM 1687 CD LYS 364 -16.180 40.351 2.969 1.00 60.31 A C
ATOM 1688 CE LYS 364 -17.077 39.531 3.911 1.00 62.23 A C
ATOM 1689 NZ LYS 364 -16.575 38.136 -4 154 1.00 64.66 A N
ATOM 1690 C LYS 364 -12.895 41.688 0.513 1.00 46.10 A C
ATOM 1691 O LYS 364 -12.061 41.184 0.239 1.00 44.06 A O
ATOM 1692 N PHE 365 -13.070 42.997 -0 619 1.00 43.62 A N
ATOM 1693 CA PHE 365 -12.277 43.916 0.167 1.00 42.06 A C
ATOM 1694 CB PHE 365 -11.416 44.777 •0.746 00 38.49 A C
ATOM 1695 CG PHE 365 -10.460 44.007 ■1.599 00 37.06 A C
ATOM 1696 CDl PHE 365 -9.395 43.333 ■1.032 00 34.44 A C
ATOM 1697 CD2 PHE 365 -10.593 44.012 ■2.982 00 34.85 A C
ATOM , 1698 CEl PHE 365 -8.471 42.681 •1.824 00 36.01 A C
ATOM 1699 CE2 PHE 365 -9.677 43.366 ■3.780 00 35.73 A C
ATOM 1700 CZ PHE 365 -8.608 42.698 •3.202 00 36.13 A C
ATOM 1701 C PHE 365 -13.145 44.855 0.976 00 43.08 A C
ATOM 1702 O PHE 365 -14.304 45.085 0.645 00 42.88 A O
ATOM 1703 N PRO 366 -12.595 45.397 2.067 00 43.87 A N
ATOM 1704 CD PRO 366 -11.372 44.952 2.751 00 43.89 A C
ATOM 1705 CA PRO 366 -13.345 46.339 2.897 00 44.94 A C
ATOM 1706 CB PRO 366 -12.386 46.621 4.040 00 45.92 A C
ATOM 1707 CG PRO 366 -11.661 45.319 4.182 00 44.56 A C
ATOM 1708 C PRO 366 -13.505 47.541 1.973 1.00 45.25 A C
ATOM 1709 O PRO 366 -12.679 47.760 1.092 1.00 47.53 A O
ATOM 1710 N ARG 367 -14.547 48.327 2.172 1 00 46.59 A N
ATOM 1711 CA ARG 367 -14.817 49.466 1.302 1 00 46.80 A C
ATOM 1712 CB ARG 367 -16.128 50.102 1.743 1 00 49.46 A C
ATOM 1713 CG ARG 367 -17.225 49.085 1.976 1 00 51.98 A C
ATOM 1714 CD ARG 367 -18.173 49.589 3.034 1 00 54.01 A C
ATOM 1715 NE ARG 367 -18.706 50.892 2.663 1 00 54.72 A N
ATOM 1716 CZ ARG 367 -19.480 51.633 3.443 1.00 54.17 A C ATOM 1717 NHl ARG 367 -19.816 51.203 4.652 1.00 54.41 A N
ATOM 1718 NH2 ARG 367 -19.922 52.801 3.007 1.00 54.70 A N
ATOM 1719 C ARG 367 -13.726 50.534 1.224 1.00 45.76 A C
ATOM 1720 O ARG v 367 -13.296 50.929 0.136 1.00 45.38 A O
ATOM 1721 N THR 368 -13.280 50.987 2.389 1.00 43.29 A N
ATOM 1722 CA THR 368 -12.278 52.040 2.495 1.00 41.71 A C
ATOM 1723 CB THR 368 -12.370 52.664 3.877 1.00 42.06 A C
ATOM 1724 OGl THR 368 -12.263 51.629 4.860 1.00 41.55 A O
ATOM 1725 CG2 THR 368 -13.702 53.366 4.043 1.00 41.52 A C
ATOM 1726 C THR 368 -10.807 51.588 2.210 1.00 39.95 A C
ATOM 1727 O THR 368 -9.927 52.528 2.402 1.00 38.65 A O
ATOM 1728 N LEU 369 -10.542 50.460 1.767 1.00 36.51 A N
ATOM 1729 CA LEU 369 -9.178 50.043 1.447 1.00 33.11 A C
ATOM 1730 CB LEU 369 -9.144 48.562 1.094 1.00 33.86 A C
ATOM 1731 CG LEU 369 -8.067 47.715 1.763 1.00 35.26 A C
ATOM 1732 CDl LEU 369 -8.344 47.644 3.265 1.00 34.71 A C
ATOM 1733 CD2 LEU 369 -8.069 46.318 1.155 1.00 34.39 A C
ATOM 1734 C LEU 369 -8.763 50.847 0.224 1.00 31.06 A C
ATOM 1735 O LEU 369 -9.544 50.967 -0.721 1.00 28.15 A O
ATOM 1736 N SER 370 -7.543 51.383 0.228 1.00 28.72 A N
ATOM 1737 CA SER 370 -7.082 52.192 -0.896 1.00 27.03 A C
ATOM 1738 CB SER 370 -S.659 52.703 -0.661 1.00 26.93 A C
ATOM 1739 OG SER 370 -4.711 51.659 -0.666 1.00 26.53 A O
ATOM 1740 C SER 370 -7.145 51.443 -2.209 1.00 27.01 A C
ATOM 1741 O SER 370 -7.281 50.217 -2.241 1.00 27.90 A O
ATOM 1742 N SER 371 -7.067 52.194 -3.299 1.00 27.24 A N
ATOM 1743 CA SER 371 -7.108 51.611 -4.628 1.00 27.33 A C
ATOM 1744 CB SER 371 -7.193 52.716 -5.676 1.00 28.51 A C
ATOM 1745 OG SER 371 -6.995 52.189 -6.981 1.00 33.50 A O
ATOM 1746 C SER 371 -5.871 50.751 -4.884 1.00 26.61 A C
ATOM 1747 O SER 371 -5.968 49.697 -5.512 1.00 25.14 A O
ATOM 1748 N ASP 372 -4.716 51.201 -4.393 1.00 26.65 A N
ATOM 1749 CA ASP 372 -3.463 50.472 -4.572 1.00 27.85 A C
ATOM 1750 CB ASP 372 -2.269 51.363 -4.241 1.00 27.67 A C
ATOM 1751 CG ASP 372 -2.087 52.462 -5.233 1.00 30.78 A C
ATOM 1752 ODl ASP 372 -2.661 52.367 -6.342 1.00 33.18 A O
ATOM 1753 OD2 ASP 372 -1.360 53.420 -4.910 1.00 34.15 A O
ATOM 1754 C ASP 372 -3.370 49.203 -3.731 1.00 28.44 A C
ATOM 1755 O ASP 372 -2.707 48.252 -4.121 1.00 29.01 A O
ATOM 1756 N ALA 373 -4.007 49.209 -2.568 1.00 27.59 A N
ATOM 1757 CA ALA 373 -4.004 48.045 -1.692 1.00 28.97 A C
ATOM 1758 CB ALA 373 -4.564 48.419 -0.316 1.00 27.04 A C
ATOM 1759 C ALA 373 -4.844 46.933 -2.324 1.00 29.68 A C
ATOM 1760 O ALA 373 -4.423 45.782 -2.367 1.00 32.07 A O
ATOM 1761 N LYS 374 -6.032 47.284 -2.814 1.00 29.57 A N
ATOM 1762 CA LYS 374 -6.909 46.313 -3.461 1.00 29.30 A C
ATOM 1763 CB LYS 374 -8.232 46.967 -3.876 1.00 30.80 A C
ATOM 1764 CG LYS 374 -9.081 47.459 -2.714 1.00 35.29 A C
ATOM 1765 CD LYS 374 -10.405 48.032 -3.209 1.00 37.88 A C
ATOM 1766 CE LYS 374 -11.247 48.581 -2.064 1.00 40.96 A C
ATOM 1767 NZ LYS 374 -12.508 49.213 -2.556 1.00 41.66 A N
ATOM 1768 C LYS 374 -6.209 45.775 -4.701 1.00 27.72 A C
ATOM 1769 O LYS 374 -6.358 44.614 -5.060 1.00 27.38 A O
ATOM 1770 N SER 375 -5.444 46.639 -5.353 1.00 26.43 A N
ATOM 1771 CA SER 375 -4.714 46.255 -6.551 1.00 25.70 A C
ATOM 1772 CB SER 375 -4.031 47.475 -7.161 1.00 27.45 A C
ATOM 1773 OG SER 375 -3.368 47.136 -8.361 1.00 29.58 A O
ATOM 1774 C SER 375 -3.663 45.217 -6.188 1.00 25.70 A C
ATOM 1775 O SER 375 -3.628 44.112 -6.746 1.00 26.04 A O
ATOM 1776 N LEU 376 -2.808 45.578 -5.243 1.00 20.98 A N
ATOM 1777 CA LEU 376 -1.760 44.683 -4.812 1.00 22.08 A C
ATOM 1778 CB LEU 376 -0.987 45.274 -3.626 1.00 21.54 A C
ATOM 1779 CG LEU 376 0.101 44.368 -3.045 1.00 17.63 A C
ATOM 1780 CDl LEU 376 1.343 44.465 -3.889 1.00 19.62 A C
ATOM 1781 CD2 LEU 376 0.393 44.752 -1.623 1.00 17.52 A C
ATOM 1782 C LEU 376 -2.333 43.332 -4.417 1.00 22.33 A C
ATOM 1783 O LEU 376 -1.924 42.311 -4.951 1.00 21.80 A O
ATOM 1784 N LEU 377 -3.283 43.334 -3.488 1.00 24.44 A N
ATOM 1785 CA LEU 377 -3.882 42.096 -3.009 1.00 24.54 A C
ATOM 1786 CB LEU 377 -4.856 42.388 -1.869 1.00 24.17 A C
ATOM 1787 CG LEU 377 -4.266 43.128 -0.664 1.00 25.44 A C
ATOM 1788 CDl LEU 377 -5.325 43.218 0.433 1.00 26.06 A C
ATOM 1789 CD2 LEU 377 -3.032 42.404 -0.141 1.00 25.52 A C ATOM 1790 C LEU 377 •4.565 41.286 -4.108 1.00 25.57 A C
ATOM 1791 O LEU 377 •4.474 40.058 -4.124 1.00 27.99 A O
ATOM 1792 N SER 378 ■5.241 41.948 -5.033 1.00 24.87 A N
ATOM 1793 CA SER 378 -5 862 41.204 -6.117 1.00 26.87 A C
ATOM 1794 CB SER 378 649 42.121 -7.051 1.00 27.79 A C
ATOM 1795 OG ■SER 378 -7 760 42.701 -6.397 30.63 A O
ATOM 1796 C SER 378 -4 735 40.558 -6.910 27.78 A C
ATOM 1797 O SER 378 -4 778 39.366 -7.227 31.27 A O
ATOM 1798 N GLY 379 -3 720 41.3S2 -7.219 27.47 A N
ATOM 1799 CA GLY 379 ■2.588 40.873 -7.978 27.64 A C
ATOM 1800 C GLY 379 ■1.891 39.673 -7.364 27.02 A C
ATOM 1801 O GLY 379 ■1.545 38.722 -8.072 29.08 A O
ATOM 1802 N LEU 380 •1.674. 39.718 -6.055 24.27 A N
ATOM 1803 CA LEU 380 •1.014 38.634 -5.349 23.33 A C
ATOM 1804 CB LEU 380 ■0.567 39.095 -3. 968 19.82 A C
ATOM 1805 CG LEU 380 0.649 40.021 -3.888 18.95 A C
ATOM 1806 CDl LEU 380 0.853 40.444 -2.441 16.06 A C
ATOM 1807 CD2 LEU 380 1.886 39.317 -4.429 15.17 A C
ATOM 1808 C LEU 380 •1.915 37.424 -5.186 26.36 A C
ATOM 1809 O LEU 380 ■1.439 36.311 -4 985 25.94 A O
ATOM 1810 N LEU 381 •3.221 37.629 -5 266 29.26 A N
ATOM 1811 CA LEU 381 ■4.126 36.512 -5 091 29.06 A C
ATOM 1812 CB LEU 381 •5.185 36.861 -4.050 28.95 A C
ATOM 1813 CG LEU 381 -4 592 37.019 -2.644 29.76 A C
ATOM 1814 CDl LEU 381 5.678 37.401 -1.648 26.21 A C
ATOM 1815 CD2 LEU 381 3.921 35.713 -2.233 25.37 A C
ATOM 1816 C LEU 381 -4 769 36.040 -6.384 30.71 A C
ATOM 1817 O LEU 381 5.858 35.479 -6.370 29.50 A O
ATOM 1818 N ILE 382 4.090 36.271 -7.502 30.89 A N
ATOM 1819 CA ILE 382 4.587 35.818 -8.793 31.74 A C
ATOM 1820 CB ILE 382 -3.797 36.471 -9.934 29.63 A C
ATOM 1821 CG2 ILE 382 -3.990 35.700 -11.225 29.21 A C
ATOM 1822 CGl ILE 382 -4.247 37.925 -10.096 30.29 A C
ATOM 1823 CDl ILE 382 -3.407 38.718 -11.083 29.65 A C
ATOM 1824 C ILE 382 4.413 34.291 -8.833 33.93 A C
ATOM 1825 O ILE 382 3.325 33.776 -8.588 35.17 A O
ATOM 1826 N LYS 383 -5 492 33.578 -9.131 35.00 A N
ATOM 1827 CA LYS 383 ■5.475 32.120 -9.170 1.00 37.32 A C
ATOM 1828 CB LYS 383 •6.827 31.599 -9.662 37.85 A C
ATOM 1829 CG LYS 383 ■8.043 32.259 -9.001 36.27 A C
ATOM 1830 CD LYS 383 ■8.135 31.962 -7.514 35.24 A C
ATOM 1831 CE LYS 383 •9.494 32.366 -6.963 35.37 A C
ATOM 1832 NZ LYS 383 ■9.512 32.417 -5.474 34.67 A N
ATOM 1833 C LYS 383 -4 355 31.523 -10.023 38.28 A C
ATOM 1834 O LYS 383 •3.584 30.697 -9.537 39.67 A O
ATOM 1835 N ASP 384 ■4.257 31.929 -11.288 39.48 A N
ATOM 1836 CA ASP 384 -3 208 31.400 -12.163 39.29 A C
ATOM 1837 CB ASP 384 3.466 31.781 -13.620 42.82 A C
ATOM 1838 CG ASP 384 ■2.503 31.092 -14.587 43.62 A C
ATOM 1839 ODl ASP 384 1.474 30.543 -14.135 44.29 A O
ATOM 1840 OD2 ASP 384 -2 780 31.110 -15.806 46.11 A O
ATOM 1841 C ASP 384 ■1.858 31.952 -11.745 38.46 A C
ATOM 1842 O ASP 384 ■1.621 33.152 -11.812 37.87 A O
ATOM 1843 N PRO 385 -0 952 31.070 -11.315 38.18 A N
ATOM 1844 CD PRO 385 -1.200 29.623 -11.214 37.96 A C
ATOM 1845 CA PRO 385 0.403 31.399 -10.865 37.67 A C
ATOM 1846 CB PRO 385 0.949 30.050 -10.407 38.13 A C
ATOM 1847 CG PRO 385 0.192 29.071 -11.258 38.89 A C
ATOM 1848 C PRO 385 .322 32.088 -11.875 38.64 A C
ATOM 1849 O PRO 385 .287 32.756 -11.491 38.93 A O
ATOM 1850 N ASN 386 .043 31.936 -13.161 38.89 A N
ATOM 1851 CA ASN 38S .897 32.573 -14.153 38.99 A C
ATOM 1852 CB ASN 386 .929 31.744 -15.439 42.72 A C
ATOM 1853 CG ASN 386 .891 30.574 -15.347 44.88 A C
ATOM 1854 ODl ASN 386 .728 29.686 -14.512 48.87 A O
ATOM 1855 ND2 ASN 386 .908 30.573 -16.202 47.85 A N
ATOM 1856 C ASN 386 1.451 34.002 -14.438 36.99 A C
ATOM 1857 O ASN 386 2.204 34.806 -14.991 34.58 A O
ATOM 1858 N LYS 387 0.225 34.310 -14.035 34.18 A N
ATOM 1859 CA LYS 387 -0.332 35.637 -14.227 32.57 A C
ATOM 1860 CB LYS 387 -1.774 35.530 -14.721 33.74 A C
ATOM 1861 CG LYS 387 -1.932 34.857 -16.070 38.12 A C
ATOM 1862 CD LYS 387 -3.408 34.618 -16.359 1.00 42.60 A C ATOM 1863 CE LYS 387 -3.639 33.895 -17.680 44.11 A C
ATOM 1864 NZ LYS 387 -3.585 34.810 -18.859 47.71 A N
ATOM 1865 C LYS 387 -0.297 36.405 -12.908 29.78 A C
ATOM 1866 O LYS 387 -0.489 37.621 -12.881 29.31 A O
ATOM 1867 N ARG 388 -0.050 35.694 -11.814 26.45 A N
ATOM 1868 CA ARG 388 -0.002 36.327 -10.502 24.93 A C
ATOM 1869 CB ARG 388 0.250 35.273 -9.432 25.97 A C
ATOM 1870 CG ARG 388 0.094 35.758 -7.999 26.92 A C
ATOM 1871 CD ARG 388 -0.587 34.673 -7.180 27.41 A C
ATOM 1872 NE ARG 388 0.226 33.472 -7.051 29.25 A N
ATOM 1873 CZ ARG 388 -0.227 32.227 -7.193 30.11 A C
ATOM 1874 NHl ARG 388 -1.498 31.995 -7.488 29.81 A N
ATOM 1875 NH2 ARG 388 0.595 31.207 -7.006 27.57 A N
ATOM 1876 C ARG 388 1.091 37.387 -10.452 25.23 A C
ATOM 1877 O ARG 388 2.073 37.316 -11.187 23.79 A O
ATOM 1878 N LEU 389 0.909 38.384 -9.596 24.00 A N
ATOM 1879 CA LEU 389 1.899 39.442 -9.439 22.46 A C
ATOM 1880 CB LEU 389 1.336 40.554 -8.554 21.33 A C
ATOM 1881 CG LEU 389 2.246 41.770 -8.359 22.91 A C
ATOM 1882 CDl LEU 389 2.237 42.619 -9.632 18.84 A C
ATOM 1883 CD2 LEU 389 1.773 42.582 -7.164 17. S3 A C
ATOM 1884 C LEU 389 3.139 38.825 -8.773 21.58 A C
ATOM 1885 O LEU 389 3.027 38.177 -7.740 18.73 A O
ATOM 1886 N GLY 390 4.313 39.031 -9.367 21.05 A N
ATOM 1887 CA GLY 390 5.531 38.466 -8.822 18.84 A C
ATOM 1888 C GLY 390 5.851 37.148 -9.505 22.62 A C
ATOM 1889 O GLY 390 6.973 36.639 -9.413 23.02 A O
ATOM 1890 N GLY 391 4.862 36.607 -10.213 23.02 A N
ATOM 1891 CA GLY 391 5.020 35.334 -10.893 24.42 A C
ATOM 1892 C GLY 391 5.785 35.368 -12.208 26.70 A C
ATOM 1893 O GLY 391 6.096 34.320 -12.774 24.55 A O
ATOM 1894 N GLY 392 6.099 36.568 -12.687 26.65 A N
ATOM 1895 CA GLY 392 6.833 36.697 -13.932 27.03 A C
ATOM 1896 C GLY 392 8.327 36.464 -13.777 27.56 A C
ATOM 1897 O GLY 392 8.790 36.038 -12.725 26.81 A O
ATOM 1898 N PRO 393 9.112 36.744 -14.821 27.02 A N
ATOM 1899 CD PRO 393 8.637 37.097 -16.168 24.62 A C
ATOM 1900 CA PRO 393 10.565 36.558 -14.805 26.94 A C
ATOM 1901 CB PRO 393 10.933 36.658 -16.283 25.65 A C
ATOM 1902 CG PRO 393 9.892 37.585 -16.829 24.77 A C
ATOM 1903 C PRO 393 11.378 37.512 -13.918 28.61 A C
ATOM 1904 O PRO 393 12.549 37.248 -13.634 28.33 A O
ATOM 1905 N ASP 394 10.772 38.610 -13.472 28.01 A N
ATOM 1906 CA ASP 394 11.490 39.546 -12.612 26.81 A C
ATOM 1907 CB ASP 394 11.148 40.990 -12.976 26.96 A C
ATOM 1908 CG ASP 394 12.382 41.845 -13.160 27.21 A C
ATOM 1909 ODl ASP 394 13.479 41.269 -13.280 28.97 A O
ATOM 1910 OD2 ASP 394 12.263 43.088 -13.194 29.08 A O
ATOM 1911 C ASP 394 11.124 39.266 -11.167 26.39 A C
ATOM 1912 O ASP 394 11.534 39.980 -10.258 27.26 A O
ATOM 1913 N ASP 395 10.331 38.219 -10.975 24.38 A N
ATOM 1914 CA ASP 395 9.911 37.781 -9.655 24.37 A C
ATOM 1915 CB ASP 395 11.041 36.952 -9.029 25.42 A C
ATOM 1916 CG ASP 395 10.637 36.278 -7.729 26.87 A C
ATOM 1917 ODl ASP 395 9.728 35.426 -7.740 24.04 A O
ATOM 1918 OD2 ASP 395 11.246 36.601 -6.691 27.51 A O
ATOM 1919 C ASP 395 9.511 38.933 -8.736 24.85 A C
ATOM 1920 O ASP 395 8.601 39.694 -9.049 24.98 A O
ATOM 1921 N ALA 396 10.197 39.057 -7.605 25.29 A N
ATOM 1922 CA ALA 396 9.905 40.091 -6.618 26.04 A C
ATOM 1923 CB ALA 396 10.923 40.022 -5.490 24.54 A C
ATOM 1924 C ALA 396 9.822 41.523 -7.137 26.62 A C
ATOM 1925 O ALA 396 9.142 42.351 -6.543 28.35 A O
ATOM 1926 N LYS 397 10.503 41.820 -8.235 29.27 A N
ATOM 1927 CA LYS 397 10.496 43.175 -8.774 29.84 A C
ATOM 1928 CB LYS 397 11.494 43.306 -9.928 33.89 A C
ATOM 1929 CG LYS 397 12.820 43.934 -9.529 37.97 A C
ATOM 1930 CD LYS 397 13.934 42.920 -9.393 43.15 A C
ATOM 1931 CE LYS 397 13.646 41.919 -8.291 46.98 A C
ATOM 1932 NZ LYS 397 14.749 40.925 -8.138 50.39 A N
ATOM 1933 C LYS 397 9.132 A3.619 -9.218 28.65 A C
ATOM 1934 O LYS 397 8.855 44.874 -9.123 28.78 A 0
ATOM 1935 N GLU 398 1.275 42.787 -9.703 1.00 27.47 A N ATOM 1936 CA GLU 398 6.941 43.211 -10.117 1.00 24.23 A C
ATOM 1937 CB GLU 398 6.133 42.038 -10.655 1.00 26.91 A C
ATOM 1938 CG GLU 398 6.802 41.266 -11.772 1.00 29.25 A C
ATOM 1939 CD GLU 398 5.924 40.147 -12.298 1.00 32.84 A C
ATOM 1940 OEl GLU 398 6.444 39.285 -13.036 1.00 35.78 A O
ATOM 1941 OE2 GLU 398 4.712 40.132 -11.984 1.00 30.90 A O
ATOM 1942 C GLU 398 6.223 43.767 -8.900 1.00 23.81 A C
ATOM 1943 O GLU 398 5.423 44.699 -8.997 1.00 23.41 A O
ATOM 1944 N ILE 399 6.515 43.192 -7.743 1.00 21.23 A N
ATOM 1945 CA ILE 399 5.878 43.639 -6.523 1.00 21.43 A C
ATOM 1946 CB ILE 399 5.890 42.512 -5.476 1.00 22.07 A C
ATOM 1947 CG2 ILE 399 5.277 42.983 -4.184 1.00 21.84 A C
ATOM 1948 CGl ILE 399 5.130 41.307 -6.024 1.00 20.32 A C
ATOM 1949 CDl ILE 399 5.177 40.122 -5.127 1.00 24.06 A C
ATOM 1950 C ILE 399 6.566 44.893 -5.991 1.00 23.04 A C
ATOM 1951 O ILE 399 5.911 45.807 -5.500 1.00 24.80 A O
ATOM 1952 N MET 400 7.884 44.945 -6.113 1.00 23.46 A N
ATOM 1953 CA MET 400 8.630 46.099 -5.644 1.00 24.12 A C
ATOM 1954 CB MET 400 10.128 45.825 -5.700 1.00 24.26 A C
ATOM 1955 CG MET 400 10.559 44.663 -4.841 1.00 28.26 A C
ATOM 195S SD MET 400 12.351 44.541 -4.722 1.00 31.55 A S
ATOM 1957 CE MET 400 12.736 43.872 -6.295 1.00 36.71 A C
ATOM 1958 C MET 400 8.312 47.346 -6.463 1.00 25.04 A C
ATOM 1959 O MET 400 8.488 48.462 -5.976 1.00 23.28 A O
ATOM 1960 N ARG 401 7.851 47.153 -7.701 1.00 22.92 A N
ATOM 1961 CA ARG 401 7.512 48.278 -8.575 1.00 24.85 A C
ATOM 1962 CB ARG 401 7.836 47.977 -10.050 1.00 24.45 A C
ATOM 1963 CG ARG 401 9.308 47.931 -10.412 1.00 22.18 A C
ATOM 1964 CD ARG 401 9.476 47.821 -11.916 1.00 21.97 A C
ATOM 1965 NE ARG 401 8.975 46.560 -12.465 1.00 23.84 A N
ATOM 1966 CZ ARG 401 9.731 45.485 -12.672 1.00 22.75 A C
ATOM 1967 NHl ARG 401 11.025 45.514 -12.383 1.00 22.89 A N
ATOM 1968 NH2 ARG 401 9.194 44.377 -13.155 1.00 21.54 A N
ATOM 1969 C ARG 401 6.041 48.621 -8.492 1.00 24.79 A C
ATOM 1970 O ARG 401 5.602 49.595 -9.083 1.00 27.74 A O
ATOM 1971 N HIS 402 5.274 47.807 -7.780 1.00 25.30 A N
ATOM 1972 CA HIS 402 3.849 48.049 -7.659 1.00 24.70 A C
ATOM 1973 CB HIS 402 3.168 46.889 -6.930 1.00 26.10 A C
ATOM 1974 CG HIS 402 1.677 46.991 -6.907 1.00 25.93 A C
ATOM 1975 CD2 HIS 402 0.836 47.565 -6.014 1.00 25.76 A C
ATOM 1976 NDl HIS 402 0.883 46.498 -7.921 1.00 24.94 A N
ATOM 1977 CEl HIS 402 -0.384 46.762 -7.650 1.00 23.30 A C
ATOM 1978 NE2 HIS 402 -0.439 47.409 -6.499 1.00 24.92 A N
ATOM 1979 C HIS 402 3.517 49.352 -6.932 1.00 25.04 A C
ATOM 1980 O HIS 402 4.106 49.692 -5.912 1.00 25.64 A O
ATOM 1981 N SER 403 2.541 50.056 -7.483 1.00 24.29 A N
ATOM 1982 CA SER 403 2.038 51.316 -6.968 1.00 22.28 A C
ATOM 1983 CB SER 403 0.675 51.588 -7.611 1.00 22.78 A C
ATOM 1984 OG SER 403 0.256 52.917 -7.385 1.00 33.79 A O
ATOM 1985 C SER 403 1.893 51.346 -5.442 1.00 20.65 A C
ATOM 1986 O SER 403 2.187 52.356 -4.808 1.00 19.48 A O
ATOM 1987 N PHE 404 1.427 50.247 -4.854 1.00 18.63 A N
ATOM 1988 CA PHE 404 1.254 50.196 -3.411 1.00 19.15 A C
ATOM 1989 CB PHE 404 0.682 48.846 -2.986 1.00 19.37 A C
ATOM 1990 CG PHE 404 0.458 48.729 -1.501 1.00 20.24 A C
ATOM 1991 CDl PHE 404 -0.599 49.366 -0.896 1.00 18.67 A C
ATOM 1992 CD2 PHE 404 1.333 48.011 -0.708 1.00 19.51 A C
ATOM 1993 CEl PHE 404 -0.778 49.293 0.467 1.00 20.86 A C
ATOM 1994 CE2 PHE 404 1.156 47.940 0.653 1.00 21.63 A C
ATOM 1995 CZ PHE 404 0.099 48.582 1.241 1.00 18.64 A C
ATOM 1996 C PHE 404 2.567 50.469 -2.653 1.00 19.15 A C
ATOM 1997 O PHE 404 2.549 50.910 -1.501 1.00 18.72 A O
ATOM 1998 N PHE 405 3.701 50.206 -3.289 1.00 16.73 A N
ATOM 1999 CA PHE 405 4.989 50.450 -2.649 1.00 19.73 A C
ATOM 2000 CB PHE 405 5.864 49.214 -2.737 1.00 16.88 A C
ATOM 2001 CG PHE 405 5.388 48.079 -1.909 1.00 17.10 A C
ATOM 2002 CDl PHE 405 5.427 48.156 -0.528 1.00 15.75 A C
ATOM 2003 CD2 PHE 405 4.950 46.904 -2.508 1.00 12.55 A C
ATOM 2004 CEl PHE 405 5.046 47.078 0.242 1.00 15.84 A C
ATOM 2005 CE2 PHE 405 4.567 45.828 -1.748 1.00 16.58 A C
ATOM 2006 CZ PHE 405 4.614 45.907 -0.367 1.00 14.81 A C
ATOM 2007 C PHE 405 5.745 51.604 -3.309 1.00 22.10 A C
ATOM 2008 O PHE 405 6.940 51.776 -3.072 1.00 21.77 A O ATOM 2009 N SER 406 5.063 52.384 -4.140 1.00 23.42 A N
ATOM 2010 CA SER 406 5.722 53.483 -4.833 1.00 25.80 A C
ATOM 2011 CB SER 406 4.697 54.353 -5.564 1.00 25.29 A C
ATOM 2012 OG SER 406 3.722 54.865 -4.681 1.00 30.65 A O
ATOM 2013 C SER 406 6.627 54.363 -3.969 1.00 25.30 A C
ATOM 2014 O SER 406 7.603 54.907 -4.472 1.00 29.25 A O
ATOM 2015 N GLY 407 6.336 54.502 -2.681 1.00 24.74 A N
ATOM 2016 CA GLY 407 7.186 55.343 -1.851 1.00 22.93 A C
ATOM 2017 C GLY 407 8.314 54.667 -1.059 1.00 24.87 A C
ATOM 2018 O GLY 407 8.961 55.316 -0.233 1.00 23.73 A O
ATOM 2019 N VAL 408 8.582 53.385 -1.288 1.00 20.41 A N
ATOM 2020 CA VAL 408 9.621 52.759 -0.511 1.00 22.42 A C
ATOM 2021 CB VAL 408 9.195 51.375 0.026 1.00 22.79 A C
ATOM 2022 CGl VAL 408 7.672 51.301 0.191 1.00 21.93 A C
ATOM 2023 CG2 VAL 408 9.735 50.300 -0.855 1.00 25.93 A C
ATOM 2024 C VAL 408 10.963 52.614 -1.206 1.00 23.74 A C
ATOM 2025 O VAL 408 11.043 52.314 -2.402 1.00 22.08 A O
ATOM 2026 N ASN 409 12.020 52.893 -0.441 1.00 23.44 A N
ATOM 2027 CA ASN 409 13.384 52.755 -0.927 1.00 23.03 A C
ATOM 2028 CB ASN 409 14.320 53.749 -0.240 1.00 23.56 A C
ATOM 2029 CG ASN 409 15.747 53.626 -0.735 1.00 26.11 A C
ATOM 2030 ODl ASN 409 16.463 52.685 -0.380 1.00 25.54 A O
ATOM 2031 ND2 ASN 409 16.162 54.564 -1.585 1.00 24.17 A N
ATOM 2032 C ASN 409 13.746 51.331 -0.538 1.00 21.60 A C
ATOM 2033 O ASN 409 13.853 51.008 0.642 1.00 18.43 A O
ATOM 2034 N TRP 410 13.907 50.477 -1.537 1.00 21.65 A N
ATOM 2035 CA TRP 410 14.207 49.084 -1.267 1.00 25.10 A C
ATOM 2036 CB TRP 410 13.973 48.260 -2.534 1.00 23.14 A C
ATOM 2037 CG TRP 410 12.521 48.227 -2.847 1.00 25.10 A C
ATOM 2038 CD2 TRP 410 11.531 47.407 -2.210 1.00 24.88 A C
ATOM 2039 CE2 TRP 410 10.272 47.815 -2.701 1.00 24.72 A C
ATOM 2040 CE3 TRP 410 11.589 46.375 -1.264 1.00 23.73 A C
ATOM 2041 CDl TRP 410 11.839 49.067 -3.683 1.00 25.88 A C
ATOM 2042 NEl TRP 410 10.488 48.828 -3.599 1.00 25.97 A N
ATOM 2043 CZ2 TRP 410 9.079 47.225 -2.278 1.00 24.70 A C
ATOM 2044 CZ3 TRP 410 10.409 45.794 -0.842 1.00 24.02 A C
ATOM 2045 CH2 TRP 410 9.168 46.220 -1.350 1.00 26.30 A C
ATOM 2046 C TRP 410 15.556 48.768 -0.637 1.00 25.27 A C
ATOM 2047 O TRP 410 15.697 47.755 0.039 1.00 25.87 A O
ATOM 2048 N GLN 411 16.552 49.620 -0.839 1.00 27.65 A N
ATOM 2049 CA GLN 411 17.840 49.355 -0.215 1.00 27.47 A C
ATOM 2050 CB GLN 411 18.944 50.249 -0.790 1.00 30.57 A C
ATOM 2051 CG GLN 411 20.315 49.947 -0.200 1.00 33.79 A C
ATOM 2052 CD GLN 411 20.792 48.548 -0.535 1.00 36.47 A C
ATOM 2053 OEl GLN 411 21.331 47.840 0.314 1.00 37.83 A O
ATOM 2054 NE2 GLN 411 20.596 48.144 -1.783 1.00 40.51 A N
ATOM 2055 C GLN 411 17.652 49.639 1.265 1.00 25.53 A C
ATOM 2056 O GLN 411 18.151 48.905 2.116 1.00 24.88 A O
ATOM 2057 N ASP 412 16.899 50.694 1.565 1.00 22.91 A N
ATOM 2058 CA ASP 412 15.617 51.059 2.947 1.00 22.83 A C
ATOM 2059 CB ASP 412 15.848 52.387 3.017 1.00 23.84 A C
ATOM 2060 CG ASP 412 16.755 53.597 2.908 1.00 22.08 A C
ATOM 2061 ODl ASP 412 17.972 53.417 2.688 1.00 23.35 A O
ATOM 2062 OD2 ASP 412 16.245 54.732 3.040 1.00 24.04 A O
ATOM 2063 C ASP 412 15.820 49.970 3.663 1.00 22.23 A C
ATOM 2064 O ASP 412 15.914 , 49.827 4.882 1.00 23.72 A O
ATOM 2065 N VAL 413 15.027 49.213 2.912 1.00 22.37 A N
ATOM 2066 CA VAL 413 14.248 48.133 3.509 1.00 23.02 A C
ATOM 2067 CB VAL 413 13.347 47.416 2.473 1.00 22.67 A C
ATOM 2068 CGl VAL 413 12.897 46.059 3.020 1.00 17.33 A C
ATOM 2069 CG2 VAL 413 12.147 48.277 2.140 1.00 19.22 A C
ATOM 2070 C VAL 413 15.247 47.128 4.045 1.00 23.14 A C
ATOM 2071 0 VAL 413 15.276 46.833 5.238 1.00 23.83 A O
ATOM 2072 N TYR 414 16.077 46.624 3.144 1.00 24.88 A N
ATOM 2073 CA TYR 414 17.112 45.649 3.483 1.00 26.93 A C
ATOM 2074 CB TYR 414 17.962 45.354 2.244 1.00 26.29 A C
ATOM 2075 CG TYR 414 18.919 44.217 2.442 1.00 31.21 A C
ATOM 2076 CDl TYR 414 18.509 42.902 2.253 1.00 30.46 A C
ATOM 2077 CEl TYR 414 19.367 41.848 2.488 1.00 31.87 A C
ATOM 2078 CD2 TYR 414 20.225 44.448 2.873 1.00 31.95 A C
ATOM 2079 CE2 TYR 414 21.091 43.396 3.113 1.00 32.11 A C
ATOM 2080 CZ TYR 414 20.655 42.101 2.922 1.00 32.27 A C
ATOM 2081 OH TYR 414 21.493 41.051 3.199 1.00 33.34 A O ATOM 2082 C TYR 414 18.029 46.111 4.628 1.00 25.71 A C
ATOM 2083 O TYR 414 18.359 45.335 5.514 1.00 26.61 A O
ATOM 2084 N ASP 415 18.432 47.377 4.608 1.00 27.02 A N
ATOM 2085 CA ASP 415 19.316 47.914 5.642 1.00 27.42 A C
ATOM 2086 CB ASP 415 20.062 49.135 5.111 1.00 28.00 A C
ATOM 2087 CG ASP 415 20.938 48.794 3.936 1.00 29.03 A C
ATOM 2088 ODl ASP 415 21.388 47.638 3.882 1.00 34.25 A O
ATOM 2089 OD2 ASP 415 21.183 49.659 3.077 1.00 30.92 A O
ATOM 2090 C ASP 415 18.593 48.285 6.924 1.00 29.72 A C
ATOM 209X O ASP 415 19.178 48.906 7.809 1.00 28.84 A O
ATOM 2092 N LYS 416 17.324 47.899 7.015 1.00 30.68 A N
ATOM 2093 CA LYS 416 16.495 48.180 8.179 1.00 32.27 A C
ATOM 2094 CB LYS 416 16.950 47.339 9.379 1.00 33.75 A C
ATOM 2095 CG LYS 416 16.745 45.845 9.179 1.00 38.62 A C
ATOM 2096 CD LYS 416 16.617 45.082 10.503 1.00 39.90 A C
ATOM 2097 CE LYS 416 17.888 45.096 11.326 1.00 40.64 A C
ATOM 2098 NZ LYS 416 17.661 44.509 12.683 1.00 40.75 A N
ATOM 2099 C LYS 416 16.471 49.656 8.560 1.00 31.55 A C
ATOM 2100 O LYS 416 16.452 50.000 9.744 1.00 31.49 A O
ATOM 2101 N LYS 417 16.461 50.529 7.556 1.00 31.47 A N
ATOM 2102 CA LYS 417 16.430 51.965 7.813 1.00 32.10 A C
ATOM 2103 CB LYS 417 17.259 52.708 6.771 1.00 32.16 A C
ATOM 2104 CG LYS 417 18.768 52.585 7.002 1.00 33.47 A C
ATOM 2105 CD LYS 417 19.546 53.235 5.876 1.00 34.54 A C
ATOM 2106 CE LYS 417 21.033 52.900 5.953 1.00 37.09 A C
ATOM 2107 NZ LYS 417 21.745 53.248 4.672 1.00 35.22 A N
ATOM 2108 C LYS 417 15.026 52.565 7.906 1.00 33.30 A C
ATOM 2109 O LYS 417 14.872 53.706 8.347 1.00 34.76 A O
ATOM 2110 N LEU 418 14.005 51.814 7.494 1.00 32.38 A N
ATOM 2111 CA LEU 418 12.638 52.312 7.606 1.00 34.08 A C
ATOM 2112 CB LEU 418 11.633 51.405 6.891 1.00 34.41 A C
ATOM 2113 CG LEU 418 11.758 51.141 5.393 1.00 34.87 A C
ATOM 2114 CDl LEU 418 11.739 52.451 4.624 1.00 33.30 A C
ATOM 2115 CD2 LEU 418 13.059 50.378 5.135 1.00 38.25 A C
ATOM 2116 C LEU 418 12.296 52.314 9.096 1.00 35.93 A C
ATOM 2117 O LEU 418 12.732 51.437 9.850 1.00 35.35 A O
ATOM 2118 N VAL 419 11.515 53.295 9.522 1,.OO 35.85 A N
ATOM 2119 CA VAL 419 11.126 53.377 10.916 1.00 35.54 A C
ATOM 2120 CB VAL 419 10.768 54.817 11.301 1.00 37.15 A C
ATOM 2121 CGl VAL 419 10.521 54.904 12.799 1.00 35.15 A C
ATOM 2122 CG2 VAL 419 11.897 55.747 10.877 1.00 36.30 A C
ATOM 2123 C VAL 419 9.920 52.481 11.144 1.00 34.27 A C
ATOM 2124 O VAL 419 8.844 52.719 10.603 1.00 35.37 A O
ATOM 2125 N PRO 420 10.090 51.431 11.947 1.00 33.22 A N
ATOM 2126 CD PRO 420 11.310 51.083 12.688 1.00 34.04 A C
ATOM 2127 CA PRO 420 9.008 50.492 12.243 1.00 • 34.41 A C
ATOM 2128 CB PRO 420 9.644 49.542 13.250 1.00 31.79 A C
ATOM1 2129 CG PRO 420 11.109 49.617 12.919 1.00 32.38 A C
ATOM 2130 C PRO 420 7.788 51.217 12.816 1.00 37.20 A C
ATOM 2131 O PRO 420 7.892 51.969 13.783 1.00 36.82 A O
ATOM 2132 N PRO 421 6.611 50.994 12.223 1.00 38.40 A N
ATOM 2133 CD PRO 421 6.286 49.940 11.248 1.00 38.07 A C
ATOM 2134 CA PRO 421 5.396 51.652 12.708 1.00 39.03 A C
ATOM 2135 CB PRO 421 4.325 51.132 11.759 1.00 36.74 A C
ATOM 2136 CG PRO 421 4.804 49.732 11.495 1.00 38.90 A C
ATOM 2137 C PRO 421 5.108 51.300 14.168 1.00 40.25 A C
ATOM 2138 O PRO 421 4.619 52.138 14.926 1.00 40.87 A O
ATOM 2139 N PHE 422 5.425 50.066 14.554 1.00 40.74 A N
ATOM 2140 CA PHE 422 5.201 49.613 15.920 1.00 41.16 A C
ATOM 2141 CB PHE 422 4.235 48.436 15.952 1.00 40.02 A C
ATOM 2142 CG PHE 422 4.072 47.843 17.320 1.00 40.83 A C
ATOM 2143 CDl PHE 422 3.220 48.428 18.248 1.00 41.61 A C
ATOM 2144 CD2 PHE 422 4.818 46.744 17.704 1.00 38.14 A C
ATOM 2145 CEl PHE 422 3.122 47.926 19.533 1.00 40.02 A C
ATOM 2146 CE2 PHE 422 4.725 46.241 18.983 1.00 39.30 A C
ATOM 2147 CZ PHE 422 3.878 46.832 19.899 1.00 41.00 A C
ATOM 2148 C PHE 422 6.485 49.174 16.610 1.00 44.18 A C
ATOM 2149 O PHE 422 7.147 48.241 16.162 1.00 43.35 A O
ATOM 2150 N LYS 423 6.824 49.830 17.715 1.00 45.87 A N
ATOM 2151 CA LYS 423 8.023 49.479 18.461 1.00 49.03 A C
ATOM 2152 CB LYS 423 8.719 50.754 18.959 1.00 49.68 A C
ATOM 2153 CG LYS 423 10.203 50.590 19.272 1.00 53.64 A C
ATOM 2154 CD LYS 423 10.439 49.483 20.298 1.00 56.01 A C ATOM 215S CK LYS 423 11.912 49.355 20.684 1.00 57.40 A C
ATOM 2156 NZ LYS 423 12.126 48.309 21.745 00 58.34 A N
ATOM 2157 C LYS 423 7.611 48.599 19.645 00 49.95 A C
ATOM 2158 O LYS 423 6.854 49.031 20.512 00 51.44 A O
ATOM 2159 N PRO 424 8.090 47.342 19.688 00 50.31 A N
ATOM 2160 CD PRO 424 8.930 46.633 18.712 00 50.39 A C
ATOM 2161 CA PRO 424 7.732 46.450 20.797 00 50.93 A C
ATOM 2162 CB PRO 424 8.430 45.140 20.432 00 50.27 A C
ATOM 2163 CG PRO 424 8.530 45.201 18.949 1.00 49.83 A C
ATOM 2164 C PRO 424 8.250 47.027 22.110 1.00 51.83 A C
ATOM 2165 O PRO 424 9.344 47.596 22.158 1.00 51.19 A O
ATOM 2166 N GLN 425 7.476 46.877 23.177 1.00 53.63 A N
ATOM 2167 CA GLN 425 7.898 47.413 24.461 1.00 55.70 A C
ATOM 2168 CB GLN 425 6.699 48.000 25.213 00 56.91 A C
ATOM 2169 CG GLN 425 6.126 49.252 24.563 00 58.80 A C
ATOM 2170 CD GLN 425 7.164 50.349 24.381 00 60.41 A C
ATOM 2171 OEl GLN 425 7.647 50.942 25.352 00 60.32 A O
ATOM 2172 NE2 GLN 425 7.519 50.621 23.129 00 61.95 A N
ATOM 2173 C GLN 425 8.631 46.424 25.357 00 55.81 A C
ATOM 2174 O GLN 425 8.194 46.157 26.475 00 55.55 A O
ATOM 2175 N VAL 426 9.741 45.881 24.860 00 55.71 A N
ATOM 2176 CA VAL 426 10.555 44.956 25.643 00 55.50 A C
ATOM 2177 CB VAL¬ 426 11.255 43.897 24.765 1.00 54.71 A C
ATOM 2178 CGl VAL 426 10.221 43.036 24.051 1.00 53.15 A C
ATOM 2179 CG2 VAL 426 12.189 44.584 23.777 1.00 52.43 A C
ATOM 2180 C VAL 426 11.621 45.832 26.285 1.00 56.29 A C
ATOM 2181 O VAL 426 12.063 46.811 25.683 1.00 56.33 A O
ATOM 2182 N THR 427 12.035 45.482 27.498 1.00 55.95 A N
ATOM 2183 CA THR 427 13.033 46.268 28.212 1.00 55.97 A C
ATOM 2184 CB THR 427 12.622 46.451 29.682 1.00 57.15 A C
ATOM 2185 OGl THR 427 12.307 45.173 30.259 1.00 57.99 A O
ATOM 2186 CG2 THR 427 11.408 47.367 29.776 1.00 56.23 A C
ATOM 2187 C THR 427 14.447 45.703 28.165 00 55.52 A C
ATOM 2188 O THR 427 15.377 46.312 28.684 00 56.22 A O
ATOM 2189 N SER 428 14.612 44.543 27.545 00 53.93 A N
ATOM 2190 CA SER 428 15.928 43.925 27.440 00 54.11 A C
ATOM 2191 CB SER 428 16.345 43.305 28.778 00 54.01 A C
ATOM 2192 OG SER 428 15.524 42.205 29.126 00 53.53 A O
ATOM 2193 C SER 428 15.873 42.852 26.372 00 54.53 A C
ATOM 2194 O SER 428 14.813 42.300 26.100 00 55.83 A O
ATOM 2195 N GLU 429 17.011 42.554 25.760 00 54.35 A N
ATOM 2196 CA GLU 429 17.033 41.545 24.715 00 53.70 A C
ATOM 2197 CB GLU 429 18.436 41.418 24.121 00 55.02 A C
ATOM 2198 CG GLU 429 19.487 40.920 25.087 00 56.47 A C
ATOM 2199 CD GLU 429 20.853 40.844 24.440 00 56.87 A C
ATOM 2200 OEl GLU 429 21.420 41.911 24.119 00 58.43 A O
ATOM 2201 OE2 GLU 429 21.357 39.719 24.240 00 57.45 A O
ATOM 2202 C GLU 429 16.581 40.204 25.274 00 51.71 A C
ATOM 2203 O GLU 429 16.336 39.259 24.526 00 51.72 A O
ATOM 2204 N THR 430 16.458 40.138 26.595 1.00 49.29 A N
ATOM 2205 CA THR 430 16.038 38.915 27.265 1.00 47.71 A C
ATOM 2206 CB THR 430 16.830 38.697 28.563 00 48.94 A C
ATOM 2207 OGl THR 430 18.170 38.301 28.249 00 51.93 A O
ATOM 2208 CG2 THR 430 16.178 37.625 29.404 00 51.13 A C
ATOM 2209 C THR 430 14.563 38.932 27.617 00 45.68 A C
ATOM 2210 O THR 430 13.913 37.892 27.658 00 46.30 A O
ATOM 2211 N ASP 431 14.042 40.121 27.884 00 43.39 A N
ATOM 2212 CA ASP 431 12.643 40.285 28.249 00 41.86 A C
ATOM 2213 CB ASP 431 12.240 41.743 28.018 00 40.94 A C
ATOM 2214 CG ASP 431 10.825 42.028 28.434 00 40.49 A C
ATOM 2215 ODl ASP 431 10.498 43.213 28.643 00 43.38 A O
ATOM 2216 OD2 ASP 431 10.036 41.073 28.544 00 41.29 A O
ATOM 2217 C ASP 431 11.745 39.332 27.456 00 40.95 A C
ATOM 2218 O ASP 431 11.769 39.328 26.229 00 42.46 A O
ATOM 2219 N THR 432 10.960 38.523 28.163 1.00 39.37 A N
ATOM 2220 CA THR 432 10.063 37.558 27.526 .00 38.12 A C
ATOM 2221 CB THR 432 10.131 36.186 28.221 .00 36.77 A C
ATOM 2222 OGl THR 432 9.738 36.326 29.593 .00 37.05 A O
ATOM 2223 CG2 THR 432 11.533 35.629 28.154 .00 34.30 A C
ATOM 2224 C THR 432 8.615 38.027 27.567 .00 39.47 A C
ATOM 2225 O THR 432 7.687 37.250 27.332 1.00 38.06 A O
ATOM 2226 N ARG 433 8.431 39.303 27.879 1.00 41.29 A N
ATOM 2227 CA ARG 433 7.106 39.906 27.962 1.00 45.22 A C ATOM 2228 CB ARG 433 7.208 41.396 27.629 1.00 48.80 A C
ATOM 2229 CG ARG 433 5.943 42.199 27.876 1.00 53.99 A C
ATOM 2230 CD ARG 433 6.160 43.671 27.490 1.00 58.05 A C
ATOM 2231 NE ARG 433 7.407 44.219 28.038 1.00 61.41 A N
ATOM 2232 CZ ARG 433 7.660 44.396 29.335 1.00 61.66 A C
ATOM 2233 NHl ARG 433 6.751 44.073 30.246 1.00 63.30 A N
ATOM 2234 NH2 ARG 433 8.828 44.890 29.726 1.00 61.38 A N
ATOM 2235 C ARG 433 6.078 39.251 27.036 1.00 45.30 A C
ATOM 2236 O ARG 433 5.197 38.519 27.479 1.00 45.47 A O
ATOM 2237 N TYR 434 6.213 39.517 25.742 1.00 44.58 A N
ATOM 2238 CA TYR 434 5.291 39.007 24.742 1.00 44.41 A C
ATOM 2239 CB TYR 434 5.735 39.501 23.362 1.00 42.83 A C
ATOM 2240 CG TYR 434 5.627 41.003 23.266 1.00 42.47 A C
ATOM 2241 CDl TYR 434 4.390 41.615 23.138 1.00 42.90 A C
ATOM 2242 CEl TYR 434 4.267 42.988 23.167 1.00 43.63 A C
ATOM 2243 CD2 TYR 434 6.750 41.815 23.413 1.00 42.33 A C
ATOM 2244 CE2 TYR 434 6.641 43.194 23.444 1.00 42.15 A C
ATOM 2245 CZ TYR 434 5.392 43.778 23.324 1.00 44.09 A C
ATOMi 2246 OH TYR 434 5.254 45.153 23.390 1.00 45.88 A O
ATOM 2247 C TYR 434 5.024 37.509 24.731 1.00 45.20 A C
ATOM 2248 O TYR 434 3.973 37.074 24.255 1.00 45.86 A O
ATOM 2249 N PHE 435 5.950 36.708 25.245 1.00 46.12 A N
ATOM 2250 CA PHE 435 5.717 35.269 25.277 1.00 45.73 A C
ATOM 2251 CB PHE 435 7.024 34.479 25.407 1.00 45.00 A C
ATOM 2252 CG PHE 435 7.861 34.467 24.166 1.00 42.78 A C
ATOM 2253 CDl PHE 435 8.885 35.378 23.994 1.00 42.96 A C
ATOM 2254 CD2 PHE 435 7.620 33.544 23.168 1.00 41.40 A C
ATOM 2255 CEl PHE 435 9.654 35.365 22.849 1.00 43.44 A C
ATOM 2256 CE2 PHE 435 8.381 33.528 22.026 1.00 40.02 A C
ATOM 2257 CZ PHE 435 9.399 34.439 21.866 1.00 40.02 A C
ATOM 2258 C PHE 435 4.839 34.948 26.476 1.00 49.10 A C
ATOM 2259 O PHE 435 4.201 33.898 26.528 1.00 47.94 A O
ATOM 2260 N ASP 436 4.822 35.862 27.440 1.00 51.46 A N
ATOM 2261 CA ASP 436 4.034 35.679 28.649 1.00 56.02 A C
ATOM 2262 CB ASP 436 4.504 36.650 29.743 1.00 55.82 A C
ATOM 2263 CG ASP 436 5.953 36.408 30.163 i:oo 55.29 A C
ATOM 2264 ODl ASP 436 6.396 35.243 30.118 1.00 54.42 A O
ATOM 2265 OD2 ASP 436 6.644 37.377 30.555 1.00 57.15 A O
ATOM 2266 C ASP 436 2.545 35.875 28.381 1.00 58.87 A C
ATOM 2267 O ASP 436 1.714 35.060 28.786 1.00 59.03 A O
ATOM 2268 N GLU 437 2.213 36.957 27.689 1.00 62.81 A N
ATOM 2269 CA GLU 437 0.826 37.259 27.364 1.00 65.67 A C
ATOM 2270 CB GLU 437 0.742 38.680 26.818 1.00 65.45 A C
ATOM 2271 CG GLU 437 1.219 39.725 27.814 1.00 65.64 A C
ATOM 2272 CD GLU 437 1.493 41.064 27.164 1.00 66.53 A C
ATOM 2273 OEl GLU 437 0.696 41.469 26.295 1.00 65.89 A O
ATOM 2274 OE2 GLU 437 2.498 41.715 27.529 1.00 67.65 A O
ATOM 2275 C GLU 437 0.276 36.264 26.348 1.00 68.41 A C
ATOM 2276 O GLU 437 0.629 35.088 26.376 1.00 68.59 A O
ATOM 2277 N GLU 438 -0.599 36.744 25.467 1.00 72.60 A N
ATOM 2278 CA GLU 438 -1.217 35.932 24.409 1.00 75.68 A C
ATOM 2279 CB GLU 438 -0.143 35.467 23.407 1.00 76.18 A C
ATOM 2280 CG GLU 438 0.949 34.578 23.996 1.00 76.55 A C
ATOM 2281 CD GLU 438 0.436 33.206 24.423 1.00 77.84 A C
ATOM 2282 OEl GLU 438 0.081 32.396 23.535 1.00 77.91 A O
ATOM 2283 0E2 GLU 438 0.387 32.936 25.645 1.00 77.45 A O
ATOM 2284 C GLU 438 -2.038 34.722 24.874 1.00 76.96 A C
ATOM 2285 O GLU 438 -2.286 33.799 24.090 1.00 77.41 A O
ATOM 2286 N PHE 439 -2.480 34.738 26.130 1.00 78.03 A N
ATOM 2287 CA PHE 439 -3.253 33.630 26.703 1.00 78.09 A C
ATOM 2288 CB PHE 439 -3.673 33.980 28.130 1.00 78.39 A C
ATOM 2289 CG PHE 439 -2.516 34.298 29.029 1.00 78.75 A C
ATOM 2290 CDl PHE 439 -1.421 33.446 29.092 1.00 78.51 A C
ATOM 2291 CD2 PHE 439 -2.520 35.440 29.811 1.00 78.21 A C
ATOM 2292 CEl PHE 439 -0.353 33.729 29.918 1.00 78.38 A C
ATOM 2293 CE2 PHE 439 -1.452 35.728 30.642 1.00 78.45 A C
ATOM 2294 CZ PHE 439 -0.367 34.872 30.695 1.00 78.38 A C
ATOM 2295 C PHE 439 -4.478 33.197 25.900 1.00 77.57 A C
ATOM 2296 0 PHE 439 -4.530 32.008 25.513 1.00 76.76 A O
ATOM 2297 OXT PHE 439 -5.371 34.039 25.674 1.00 77.84 A O
ATOM 2298 O HOH 1 18.892 34.700 8.367 1.00 39.03 W O
ATOM 2299 0 HOH 2 18.158 37.205 10.597 1.00 30.63 W O
ATOM 2300 0 HOH 3 28.583 26.941 26.027 1.00 29.55 W O ATOM 2301 O HOH 4 6.952 54.383 10.587 1.00 43.45 W O
ATOM 2302 O HOH 5 5.243 53.595 -0.468 1.00 33.52 W O
ATOM 2303 O HOH 6 15.123 51.277 -3.812 1.00 34.83 W O
ATOM 2304 O HOH 7 -1.823 52.941 1.451 1.00 23.66 W O
ATOM 2305 O HOH 8 6.638 50.680 -6.345 1.00 27.16 W O
ATOM 2306 O HOH 9 9.900 28.214 -8.897 1.00 29.50 W O
ATOM 2307 O HOH 10 -4.166 53.789 -3.318 1.00 23.11 W O
ATOM 2308 O HOH 11 5.032 30.652 1.217 1.00 33.78 W O
ATOM 2309 O HOH 12 17.589 41.865 11.701 1.00 36.85 W O
ATOM 2310 O HOH 13 3.607 53.502 5.214 1.00 40.54 W O
ATOM 2311 O HOH 14 4.751 51.739 18.405 1.00 44.80 W O
ATOM 2312 O HOH 15 -7.342 32.198 3.337 1.00 40.55 W O
ATOM 2313 O HOH 16 8.757 39.813 -14.472 1.00 39.21 W O
ATOM 2314 O HOH 17 -21.521 54.918 1.953 1.00 41.14 W O
ATOM 2315 O HOH 18 0.935 56.383 -5.319 1.00 35.84 W O
ATOM 2316 O HOH 19 -16.727 36.385 -6.584 1.00 68.70 W O
ATOM 2317 O HOH 20 -3.974 31.845 10.177 1.00 54.67 W O
ATOM 2318 O HOH 21 2.789 27.031 25.476 1.00 54.36 W O
ATOM 2319 O HOH 22 -2.327 53.879 6.177 1.00 32.11 W O
ATOM 2320 O HOH 23 -3.986 27.884 -10.576 1.00 40.01 W O
ATOM 2321 O HOH 24 13.846 37.564 -6.771 1.00 23.01 W O
ATOM 2322 O HOH 25 14.890 7.551 17.872 1.00 64.39 W O
ATOM 2323 O HOH 26 9.489 35.601 32.465 1.00 36.92 W O
ATOM 2324 O HOH 27 18.070 46.366 -1.955 1.00 41.43 W O
ATOM 2325 O HOH 28 10.559 55.352 8.109 1.00 51.88 W O
ATOM 2326 O HOH 29 -4.944 30.093 0.340 1.00 26.65 W O
ATOM 2327 O HOH 30 23.818 36.120 2.442 1.00 47.74 W O
ATOM 2328 O HOH 31 0.947 29.851 21.052 1.00 51.36 W O
ATOM 2329 O HOH 32 23.716 33.516 1.223 1.00 43.69 W O
ATOM 2330 O HOH 33 23.222 38.147 23.140 1.00 41.54 W O
ATOM 2331 O HOH 34 -7.858 35.266 -10.259 1.00 41.07 W O
ATOM 2332 O HOH 35 -7.021 43.983 22.626 1.00 58.31 W O
ATOM 2333 O HOH 36 6.373 24.180 20.297 1.00 57.53 W O
ATOM 2334 O HOH 37 10.817 31.063 17.993 1.00 55.94 W O
ATOM 2335 O HOH 38 6.328 46.587 -13.151 1.00 31.97 W O
ATOM 2336 O HOH 39 -14.749 43.474 3.598 1.00 53.82 W O
ATOM 2337 O HOH 40 6.735 47.143 13.916 1.00 25.15 W O
ATOM 2338 O HOH 41 4.446 11.873 4.575 1.00 45.91 W O
ATOM 2339 O HOH 42 0.580 45.895 18.325 1.00 44.77 W O
ATOM 2340 O HOH 43 7.440 53.619 21.362 1.00 52.05 W O
ATOM 2341 O HOH 44 6.335 29.958 -9.889 1.00 30.03 W O
ATOM 2342 O HOH 45 17.035 40.882 -0.448 1.00 33.30 W O
ATOM 2343 O HOH 46 1.192 49.387 -9.938 1.00 32.00 W O
ATOM 2344 O HOH 47 3.238 36.738 21.242 1.00 35.10 W O
ATOM 2345 O HOH 48 11.501 54.646 1.978 1.00 42.57 W O
ATOM 2346 O HOH 49 25.487 37.977 25.632 1.00 56.51 W O
ATOM 2347 O HOH 50 24.376 22.971 14.007 1.00 40.93 W O
ATOM 2348 O HOH 51 8.688 39.311 24.949 1.00 35.56 W O
ATOM 2349 O HOH 52 15.503 14.106 16.112 1.00 54.34 W O
END
Table 2. Atomic Coordinates of Akt3 (T305D and S472D) Mutant
REMARK Akt3 (T305D and S472D) Mutant coordinate to 1.95 Angstroms REMARK Residues 297 through 307 are modeled into very weak REMARK electron density and should be considered as a model REMARK of the possible conformation of this loop REMARK refinement resolution: 50.0 - 1.95 A REMARK final r= 0.2366 free_r= 0.2742 REMARK B rmsd for bonded mainchain atoras= 1.453 target= 1.5 REMARK B rmsd for bonded sidechain atoms= 1.716 target= 2.0 REMARK B rmsd for angle mainchain atoms= 2.458 target= 2.0 REMARK B rmsd for angle sidechain atoms= 2.570 target= 2.5 REMARK bulk solvent: (Mask) density level= 0.354194 e/AΛ3, B-factor= 53.3589 AΛ2 REMARK reflections with IFobs /sigma_F < 0.0 rejected REMARK reflections with |FobE > 10000 * rms(Fobs) rejected REMARK theoretical total number of refl. in resol. range: 25410 100.0 % ) REMARK number of unobserved reflections (no entry or |F|=0) : 93 0.4 % ) REMARK number of reflections rejected: 0 0.0 % ) REMARK total number of reflections used: 25317 99.6 % ) REMARK number of reflections m working set: 24075 ( 94.7 %
REMARK number of reflections in test set 1242 ( 4.9 %
ATOM 1 CB ARG 142 -4.349 55.230 29.827 1.00 69.93 C
ATOM 2 CG ARG 142 -5.339 54.408 30.639 1.00 71.05 C
ATOM 3 CD ARG 142 -6.549 55.232 31.080 1.00 72.21 C
ATOM 4 NE ARG 142 -7.306 55.776 29.952 1.00 72.57 N
ATOM 5 C2 ARG 142 -6.977 56.878 29.280 1.00 72.67 C
ATOM 6 NHl ARG 142 -5.899 57.574 29.618 1.00 72.72 N
ATOM 7 NH2 ARG 142 -7.723 57.280 28.260 1.00 72.90 N
ATOM 8 C ARG 142 -2.308 55.302 28.383 1.00 70.05 C
ATOM 9 O ARG 142 -1.089 55.367 28.538 1.00 69.95 O
ATOM 10 N ARG 142 -2.358 53.891 30.436 1.00 69.09 N
ATOM 11 CA ARG 142 -3.159 54.426 29.298 1.00 69.87 C
ATOM 12 N LYS 143 -2.959 55.974 27.435 1.00 69.92 N
ATOM 13 CA IiYS 143 -2.274 56.844 26.476 1.00 69.18 C
ATOM 14 CB LYS 143 -2.021 58.230 27.080 1.00 68.74 C
ATOM 15 CG LYS 143 -3.268 59.080 27.241 1.00 69.06 C
ATOM 16 CD LYS 143 -2.923 60.506 27.641 1.00 68.70 C
ATOM 17 CE LYS 143 -4.179 61.361 27.780 1.00 69.31 C
ATOM 18 NZ LYS 143 -4.948 61.458 26.505 1.00 69.44 N
ATOM 19 C LYS 143 -0.948 56.258 26.003 1.00 68.40 C
ATOM 20 O LYS 143 0.050 56.304 26.718 1.00 69.11 O
ATOM 21 N THR 144 -0.938 55.708 24.796 1.00 67.35 N
ATOM 22 CA THR 144 0.281 55.131 24.246 1.00 66.21 C
ATOM 23 CB THR 144 -0.022 53.910 23.372 1.00 66.05 C
ATOM 24 OGl THR 144 -0.926 54.286 22.327 1.00 66.42 O
ATOM 25 CG2 THR 144 -0.638 52.804 24.207 1.00 66.39 C
ATOM 26 C THR 144 0.966 56.177 23.387 1.00 65.16 C
ATOM 27 O THR 144 0.564 57.339 23.389 1.00 64.17 O
ATOM 28 N MET 145 1.997 55.767 22.654 1.00 64.91 N
ATOM 29 CA MET 145 2.714 56.694 21.792 1.00 64.41 C
ATOM 30 CB MET 145 3.713 55.943 20.913 1.00 64.90 C
ATOM 31 CG MET 145 4.773 55.199 21.710 1.00 56.17 C
ATOM 32 SD MET 145 5.560 56.235 22.974 1.00 66.89 S
ATOM 33 CE MET 145 6.796 57.101 22.002 1.00 66.31 C
ATOM 34 C MET 145 1.714 57.458 20.932 1.00 63.70 C
ATOM 35 O MET 145 1.978 58.581 20.506 1.00 62.90 O
ATOM 36 N ASN 146 0.562 56.846 20.676 1.00 63.51 N
ATOM 37 CA ASN 146 -0.471 57.517 19.898 1.00 63.01 C
ATOM 38 CB ASN 146 -1.595 56.545 19.531 1.00 64.69 C
ATOM 39 CG ASN 146 -1.185 55.573 18.439 1.00 66.00 C
ATOM 40 ODl ASN 146 -1.949 54.681 18.062 1.00 66.93 O
ATOM 41 ND2 ASN 146 0.029 55.745 17.920 1.00 66.18 N
ATOM 42 C ASN 146 -0.993 58.645 20.780 1.00 61.91 C
ATOM 43 O ASN 146 -0.469 58.870 21.869 1.00 62.71 O
ATOM 44 N ASP 147 -2.015 59.356 20.325 1.00 59.52 N
ATOM 45 CA ASP 147 -2.542 60.470 21.107 1.00 56.56 C
ATOM 46 CB ASP 147 -2.791 60.055 22.565 1.00 57.31 C
ATOM 47 CG ASP 147 -3.774 58.907 22.693 1.00 58.19 C
ATOM 48 ODl ASP 147 -3.385 57.747 22.439 1.00 58.13 O
ATOM 49 OD2 ASP 147 -4.944 59.170 23.043 1.00 58.38 O
ATOM 50 C ASP 147 -1.529 61.614 21.083 1.00 53.44 C
ATOM 51 O ASP 147 -1.853 62.745 21.439 1.00 53.08 O
ATOM 52 N PHE 148 -0.302 61.310 20.663 1.00 50.04 N
ATOM 53 CA PHE 148 0.766 62.308 20.597 1.00 47.22 C
ATOM 54 CB PHE 148 1.870 61.972 21.608 1.00 47.93 C
ATOM 55 CG PHE 148 1.429 62.019 23.040 1.00 46.86 C
ATOM 56 CDl PHE 148 1.026 63.211 23.617 1.00 47.69 C
ATOM 57 CD2 PHE 148 1.432 60.870 23.815 1.00 46.96 C
ATOM 58 CEl PHE 148 0.633 63.256 24.943 1.00 47.45 C
ATOM 59 CE2 PHE 148 1.042 60.908 25.138 1.00 47.12 C
ATOM 60 CZ PHE 148 0.642 62.104 25.702 1.00 46.97 C
ATOM 61 C PHE 148 1.424 62.417 19.220 1.00 44.51 C
ATOM 62 O PHE 148 1.773 61.405 18.609 1.00 43.50 O
ATOM 63 N ASP 149 1.597 63.644 18.739 1.00 42.07 N
ATOM 64 CA ASP 149 2.275 63.865 17.466 1.00 40.59 C
ATOM 65 CB ASP 149 1.851 65.181 16.805 1.00 40.25 C
ATOM 66 CG ASP 149 0.421 65.169 16.308 1.00 41.92 C
ATOM 67 ODl ASP 149 -0.035 64.120 15.805 1.00 41.85 O
ATOM 68 OD2 ASP 149 -0.237 66.227 16.401 1.00 41.96 O
ATOM 69 C ASP 149 3.755 63.985 17.825 1.00 38.87 C
ATOM 70 O ASP 149 4.106 64.724 18.745 1.00 37.35 O
ATOM 71 N TYR 150 4.613 63.250 17.126 1.00 37.49 N ATOM 72 CA TYR 150 6.052 63.324 17.368 1.00 3S.58 C
ATOM 73 CB TYR 150 6.733 62.028 16.915 1.00 39.44 C
ATOM 74 CG TYR 150 8.233 62.136 16.701 1.00 40.67 C
ATOM 75 CDl TYR 150 9.053 62.692 17.666 1.00 41.56 C
ATOM 76 CKl TYR 150 10.428 62.762 17.489 41.72 C
ATOM 77 CD2 TYR 150 8.827 61.651 15.543 40.35 C
ATOM 78 CE2 TYR 150 10.198 61.715 15.358 41.48 C
ATOM 79 CZ TYR 150 10.993 62.271 16.338 42.03 C
ATOM 80 OH TYR 150 12.361 62.320 16.181 43.89 O
ATOM 81 C TYR 150 6.560 64.509 16.557 35.51 C
ATOM 82 O TYR 150 6.540 64.475 15.326 34.46 O
ATOM 83 N LEU 151 7.007 65.558 17.242 33.13 N
ATOM 84 CA LEU 151 7.483 66.759 16.564 1.00 32.87 C
ATOM 8B CB LEU 151 7.004 68.013 17.312 00 33.58 C
ATOM 86 CG LEU 151 5.528 68.400 17.160 00 37.27 C
ATOM 87 CDl LEU 151 4.660 67.227 17.513 00 38.35 C
ATOM 88 CD2 LEU 151 5.193 69.594 18.051 00 38.30 C
ATOM 89 C LEU 151 8.987 66.869 16.324 00 32.16 C
ATOM 90 O LEU 151 9.411 67.254 15.231 00 30.95 O
ATOM 91 N LYS 152 9.797 66.555 17.331 00 31.13 N
ATOM 92 CA LYS 152 11.241 66.658 17.164 00 30.35 C
ATOM 93 CB LYS 152 11.644 68.137 17.090 00 31.81 C
ATOM 94 CG LYS 152 13.116 68.392 16.759 00 31.85 C
ATOM 95 CD LYS 152 13.352 69.850 16.377 00 35.20 C
ATOM 96 CE LYS 152 14.725 70.035 15.733 00 34.44 C
ATOM 97 NZ LYS 152 14.986 71.451 15.348 00 37.10 N
ATOM 98 C LYS 152 12.041 65.965 18.265 1.00 31.77 C
ATOM 99 O LYS 152 11.618 65.908 19.423 1.00 30.18 O
ATOM 100 N LEU 153 13.194 65.421 17.892 1.00 31.51 N
ATOM 101 CA LKU 153 14.070 64.779 18.863 1.00 32.93 C
ATOM 102 CB LEU 153 15.104 63.900 18.153 1.00 32.91 C
ATOM 103 CG LEU 153 16.140 63.224 19.058 1.00 33.32 C
ATOM 104 CDl LEU 153 15.438 62.323 20.064 1.00 34.16 C
ATOM 105 CD2 LEU 153 17.116 62.416 18.205 34.43 C
ATOM 106 C LEU 153 14.775 65.912 19.611 33.70 C
ATOM 107 O LEU 153 15.457 66.734 18.999 34.70 O
ATOM 108 N LEU 154 14.603 65.970 20.927 35.30 H
ATOM 109 CA LEU 154 15.229 67.027 21.720 37.47 C
ATOM 110 CB LEU 154 14.306 67.445 22.859 34.86 C
ATOM 111 CG LEU 154 12.967 68.023 22.409 35.18 C
ATOM 112 CDl LEU 154 12.111 68.306 23.624 34.03 C
ATOM 113 CD2 LEU 154 13.197 69.300 21.603 34.35 C
ATOM 114 C LEU 154 16.576 66.598 22.290 39.42 C
ATOM 115 O LEU 154 17.429 67.434 22.589 40.34 O
ATOM 116 N GLY 155 16.760 65.292 22.436 42.27 N
ATOM 117 CA GLY 155 18.007 64.785 22.971 45.06 C
ATOM 118 C GLY 155 18.003 63.277 23.093 47.68 C
ATOM 119 O GLY 155 16.967 62.660 23.338 46.44 O
ATOM 120 N LYS 156 19.173 62.680 22.904 51.36 N
ATOM 121 CA LYS 156 19.330 61.236 23.006 54.61 C
ATOM 122 CB LYS 156 19.245 60.586 21.622 55.17 C
ATOM 123 CG LYS 156 19.195 59.061 21.664 57.34 C
ATOM 124 CD LYS 156 19.309 58.441 20.281 57.59 C
ATOM 125 CE LYS 156 19.188 56.929 20.364 57.93 C
ATOM 126 NZ LYS 156 20.091 56.368 21.416 57.81 N
ATOM 127 C LYS 156 20.713 61.009 23.598 1.00 56.99 C
ATOM 128 O LYS 156 21.708 61.467 23.043 57.63 O
ATOM 129 N GLY 157 20.783 60.311 24.725 59.23 N
ATOM 130 CA GLY 157 22.079 60.089 25.340 62.11 C
ATOM 131 C GLY 157 22.363 58.689 25.841 63.73 C
ATOM 132 O GLY 157 21.813 57.707 25.341 64.10 O
ATOM 133 N THR 158 23.251 58.618 26.829 64.89 N
ATOM 134 CA THR 158 23.675 57.374 27.454 65.68 C
ATOM 135 CB THR 158 24.325 57.619 28.843 66.26 C
ATOM 136 OGl THR 158 25.595 58.260 28.680 66.67 O
ATOM 137 CG2 THR 158 24.517 56.300 29.584 66.50 C
ATOM 138 C THR 158 22.502 56.450 27.662 65.77 C
ATOM 139 O THR 158 22.569 55.246 27.410 66.03 O
ATOM 140 N PHE 159 21.413 57.043 28.114 65.52 N
ATOM 141 CA PHE 159 20.220 56.295 28.401 64.46 C
ATOM 142 CB PHE 159 19.546 56.942 29.610 66.82 C
ATOM 143 CG PHE 159 20.511 57.278 30.713 68.91 C
ATOM 144 CDl PHE 159 21.464 56.356 31.119 1.00 70.12 C ATOM 145 CD2 PHE 159 20.495 58.522 31.317 1.00 69.39 C
ATOM 146 CEl PHE 159 22.386 56.670 32.107 1.00 70.46 C
ATOM 147 CE2 PHE 159 21.414 58.846 32.307 1.00 69.94 C
ATOM 148 CZ PHE 159 22.362 57.917 32.701 1.00 70.67 C
ATOM 149 C PHE 159 19.289 56.195 27.193 1.00 62.73 C
ATOM 150 O PHE 159 19.539 55.407 26.279 1.00 63.48 O
ATOM 151 N GLY 160 18.223 56.987 27.181 1.00 59.68 N
ATOM 152 CA GLY 160 17.287 56.924 26.075 1.00 55.60 C
ATOM 153 C GLY 160 17.212 58.203 25.271 1.00 52.93 C
ATOM 154 O GLY 160 18.188 58.602 24.629 1.00 52.70 O
ATOM 155 N LYS 161 16.052 58.853 25.310 1.00 49.68 N
ATOM 156 CA LYS 161 15.858 60.089 24.570 1.00 46.13 C
ATOM 157 CB LYS 161 15.718 59.781 23.075 1.00 46.80 C
ATOM 158 CG LYS 161 14.575 58.843 22.715 1.00 46.89 C
ATOM 159 CD LYS 161 14.60S 58.505 21.231 1.00 49.32 C
ATOM 160 CE LYS 161 13.586 51.til 20.866 1.00 50.32 C
ATOM 161 NZ LYS 161 12.190 57.898 21.115 1.00 52.33 N
ATOM 162 C LYS 161 14.657 60.902 25.039 1.00 44.02 C
ATOM 163 O LYS 161 13.743 60.384 25.682 1.00 43.28 O
ATOM 164 N VAL 162 14.686 62.190 24.716 1.00 41.03 N
ATOM 165 CA VAL 162 13.613 63.111 25.058 1.00 38.07 C
ATOM 166 CB VAL 162 14.120 64.287 25.922 1.00 37.90 C
ATOM 167 CGl VAL 162 12.961 65.216 26.275 1.00 38.39 C
ATOM 168 CG2 VAL 162 14.770 63.756 27.186 1.00 39.45 C
ATOM 169 C VAL 162 13.103 63.655 23.733 1.00 36.00 C
ATOM 170 O VAL 162 13.889 64.045 22.869 1.00 33.43 O
ATOM 171 N ILE 163 11.786 63.676 23.583 1.00 34.39 N
ATOM 172 CA ILE 163 11.157 64.140 22.363 1.00 34.53 C
ATOM 173 CB ILE 163 10.576 62.936 21.604 1.00 36.58 C
ATOM 174 CG2 ILE 163 9.613 63.401 20.550 1.00 37.57 C
ATOM 175 CGl ILE 163 11.720 62.092 21.044 1.00 38.45 C
ATOM 176 CDl ILE 163 11.293 60.732 20.578 1.00 41.15 C
ATOM 111 C ILE 163 10.042 65.152 22.621 1.00 33.52 C
ATOM 178 O ILE 163 9.325 65.057 23.612 1.00 35.30 O
ATOM 179 N LEU 164 9.914 66.125 21.727 1.00 31.12 N
ATOM 180 CA LEU 164 8.873 67.137 21.827 1.00 30.57 C
ATOM 181 CB LEU 164 9.279 68.408 21.075 1.00 29.55 C
ATOM 182 CG LEU 164 8.163 69.437 20.862 1.00 29.21 C
ATOM 183 CDl LEU 164 7.727 70.025 .22.200 1.00 30.59 C
ATOM 184 CD2 LEU 164 8.642 70.527 19.942 1.00 31.10 C
ATOM 185 C LEU 164 7.628 66.552 21.179 1.00 29.89 C
ATOM 186 O LEU 164 7.692 66.041 20.061 1.00 31.08 O
ATOM 187 N VAL 165 6.498 66.632 21.873 1.00 32.03 N
ATOM 188 CA VAL 165 5.248 66.101 21.342 1.00 32.37 C
ATOM 189 CB VAL 165 4.868 64.752 22.004 1.00 32.07 C
ATOM 190 CGl VAL 165 5.987 63.736 21.816 1.00 31.62 C
ATOM 191 CG2 VAL 165 4.573 64.961 23.493 1.00 31.49 C
ATOM 192 C VAL 165 4.082 67.056 21.542 ■ 1.00 34.56 C
ATOM 193 O VAL 165 4.165 68.019 22.308 1.00 34.32 O
ATOM 194 N ARG 166 3.000 66.781 20.823 1.00. 36.16 N
ATOM 195 CA ARG 166 1.774 67.554 20.910 1.00 38.52 C
ATOM 196 CB ARG 166 1.468 68.269 19.585 1.00 39.43 C
ATOM 197 CG ARG 166 0.120 68.997 19.572 1.00 40.37 C
ATOM 198 CD ARG 166 -0.315 69.424 18.166 1.00 38.87 C
ATOM 199 NE ARG 166 0.481 70.529 17.632 1.00 39.08 N
ATOM 200 CZ ARG 166 1.155 70.481 16.486 1.00 37.28 C
ATOM 201 NHl ARG 166 1.138 69.377 15.746 1.00 36.26 N
ATOM 202 NH2 ARG 166 1.837 71.542 16.073 1.00 38.08 N
ATOM 203 C ARG 1S6 0.701 66.511 21.184 1.00 40.34 C
ATOM 204 O ARG 166 0.567 65.545 20.436 1.00 40.73 O
ATOM 205 N GLU 167 -0.040 66.677 22.271 1.00 42.12 N
ATOM 206 CA GLU 167 -1.093 65.724 22.586 1.00 43.37 C
ATOM 207 CB GLU 167 -1.636 65.968 23.997 1.00 44.71 C
ATOM 208 CG GLU 167 -2.469 64.810 24.543 1.00 46.06 C
ATOM 209 CD GLU 167 -3.211 65.170 25.817 1.00 46.71 C
ATOM 210 OEl GLU 167 -2.569 65.666 26.764 1.00 47.70 O
ATOM 211 OE2 GLU 167 -4.440 64.953 25.872 1.00 47.97 O
ATOM 212 C GLU 167 -2.189 65.958 21.553 1.00 43.62 C
ATOM 213 O GLU 167 -2.792 67.026 21.515 1.00 43.81 O
ATOM 214 N LYS 168 -2.427 64.965 20.706 1.00 44.35 N
ATOM 215 CA LYS 168 -3.435 65.075 19.655 1.00 46.88 C
ATOM 216 CB LYS 168 -3.681 63.700 19.020 1.00 47.54 C
ATOM 217 CG LYS 168 -2.504 63.183 18.205 1.00 48.28 C ATOM 218 CD LYS 168 -2.748 61.785 17.664 1.00 49.60 C
ATOM 219 CE LYS 168 -1.572 61.330 16.806 1.00 50.39 C
ATOM 220 NZ LYS 168 -1.715 59.939 16.289 1.00 50.31 N
ATOM 221 C LYS 168 -4.757 65,659 20.144 1.00 47.23 C
ATOM 222 O LYS 168 -5.269 66.627 19.576 1.00 47.14 O
ATOM 223 N ALA 169 -5.295 65.077 21.209 1.00 48.34 N
ATOM 224 CA ALA 169 -6.569 65.516 21.768 1.00 48.94 C
ATOM 225 CB ALA 169 -6.936 64.627 22.959 1.00 48.94 C
ATOM 226 C ALA 169 -6.620 66.990 22.177 1.00 48.58 C
ATOM 227 O ALA 169 -7.426 67.758 21.649 1.00 48.34 O
ATOM 228 N SER 170 -5.757 67.382 23.110 1.00 48.92 N
ATOM 229 CA SER 170 -5.724 68.754 23.614 1.00 48.77 C
ATOM 230 CB SER 170 -5.142 68.770 25.028 1.00 49.96 C
ATOM 231 OG SER 170 -3.788 68.346 25.019 1.00 49.58 O
ATOM 232 C SER 170 -4.948 69.752 22.758 1.00 48.84 C
ATOM 233 O SER 170 -5.268 70.944 22.742 1.00 48.28 O
ATOM 234 N GLY 171 -3.915 69.274 22.071 1.00 47.89 N
ATOM 235 CA GLY 171 -3.118 70.158 21.240 1.00 46.49 C
ATOM 236 C GLY 171 -2.028 70.897 22.002 1.00 45.51 C
ATOM 237 O GLY 171 -1.371 71.788 21.461 1.00 44.88 O
ATOM 238 N LYS 172 -1.826 70.538 23.265 1.00 45.03 N
ATOM 239 CA LYS 172 -0.797 71.194 24.061 1.00 43.71 C
ATOM 240 CB LYS 172 -1.196 71.215 25.540 1.00 45.12 C
ATOM 241 CG LYS 172 -2.302 72.217 25.853 1.00 47.76 C
ATOM 242 CD LYS 172 -2.508 72.403 27.353 1.00 50.39 C
ATOM 243 CE LYS 172 -3.552 73.480 27.630 1.00 51.01 C
ATOM 244 NZ LYS 172 -3.726 73.760 29.086 1.00 51.18 N
ATOM 245 C LYS 172 0.550 70.497 23.882 1.00 42.49 C
ATOM 246 O LYS 172 0.611 69.29-7 23.596 1.00 41.29 O
ATOM 247 N TYR 173 1.629 71.253 24.051 1.00 40.55 N
ATOM 248 CA TYR 173 2.955 70.699 23.887 1.00 38.88 C
ATOM 249 CB TYR 173 3.901 71.763 23.310 1.00 38.82 C
ATOM 250 CG TYR 173 3.411 72.332 21.999 1.00 39.05 C
ATOM 251 CDl TYR 173 2.651 73.501 21.960 1.00 39.04 C
ATOM 252 CEl TYR 173 2.183 74.006 20.764 1.00 39.31 C
ATOM 253 CD2 TYR 173 3.669 71.679 20.800 1.00 39.81 C
ATOM 254 CE2 TYR 173 3.192 72.175 19.600 1.00 39.52 C
ATOM 255 CZ TYR 173 2.451 73.338 19.588 1.00 39.66 C
ATOM 256 OH TYR 173 1.975 73.827 18.392 1.00 39.68 O
ATOM 257 C TYR 173 3.554 70.126 25.169 1.00 38.13 C
ATOM 258 O TYR 173 3.340 70.653 26.251 1.00 37.94 O
ATOM 259 N TYR 174 4.295 69.033 25.018 1.00 37.63 N
ATOM 260 CA TYR 174 4.934 68.355 26.140 1.00 36.20 C
ATOM 261 CB TYR 174 4.069 67.190 26.629 1.00 37.29 C
ATOM 262 CG TYR 174 2.734 67.594 27.201 1.00 38.85 C
ATOM 263 CDl TYR 174 2.653 68.270 28.412 1.00 39.43 C
ATOM 264 CEl TYR 174 1.429 68.637 28.943 1.00 40.56 C
ATOM 265 CD2 TYR 174 1.554 67.296 26.532 1.00 38.78 C
ATOM 266 CE2 TYR 174 0.329 67.658 27.053 1.00 40.41 C
ATOM 267 CZ TYR 174 0.270 68.327 28.259 1.00 41.48 C
ATOM 268 OH TYR 174 -0.953 68.676 28.785 1.00 42.27 O
ATOM 269 C TYR 174 6.272 67.787 25.703 1.00 35.46 C
ATOM 270 O TYR 174 6.569 67.711 24.508 1.00 33.46 O
ATOM 271 N ALA 175 7.069 67.384 26.687 1.00 35.59 N
ATOM 272 CA ALA 175 8.359 66.765 26.440 1.00 34.21 C
ATOM 273 CB ALA 175 9.474 67.519 27.171 1.00 34.97 C
ATOM 274 C ALA 175 8.234 65.348 26.991 1.00 34.75 C
ATOM 275 O ALA 175 8.049 65.161 28.194 1.00 34.74 O
ATOM 276 N MET 176 8.315 64.356 26.109 1.00 34.36 N
ATOM 277 CA MET 176 8.217 62.962 26.527 1.00 34.94 C
ATOM 278 CB MET 176 7.401 62.152 25.525 1.00 34.59 C
ATOM 279 CG MET 176 7.276 60.690 25.922 1.00 35.50 C
ATOM 280 SD MET 176 6.539 59.645 24.651 1.00 38.25 S
ATOM 281 CE MET 176 4.850 60.239 24.648 1.00 34.48 C
ATOM 282 C MET 176 9.581 62.310 26.675 1.00 36.08 C
ATOM 283 O MET 176 10.328 62.187 25.705 1.00 36.14 O
ATOM 284 N LYS 177 9.911 61.888 27.889 1.00 37.12 N
ATOM 285 CA LYS 177 11.187 61.234 28.117 1.00 40.58 C
ATOM 286 CB LYS 177 11.759 61.612 29.488 1.00 41.88 C
ATOM 287 CG LYS 177 12.161 63.086 29.583 1.00 45.05 C
ATOM 288 CD LYS 177 12.946 63.388 30.845 1.00 46.42 C
ATOM 289 CE LYS 177 13.338 64.856 30.909 1.00 47.20 C
ATOM 290 NZ LYS 177 12.136 65.746 30.968 1.00 48.75 N ATOM 291 C LYS 177 10.969 59.737 28.014 1.00 41.82 C
ATOM 292 O LYS 177 10.077 59.181 28.649 1.00 42.76 O
ATOM 293 N ILE 178 11.779 59.094 27.186 44.10 N
ATOM 294 CA ILE 178 11.677 57.661 26.964 45.55 C
ATOM 295 CB ILE 178 11.414 57.371 25.477 45.76 C
ATOM 296 CG2 ILE 178 11.042 55.906 25.278 44.06 C
ATOM 297 CGl ILE 178 10.283 58.272 24.979 44.40 C
ATOM 298 CDl ILE 178 10.079 58.217 23.483 1.00 45.81 C
ATOM 299 C ILE 178 12.991 57.024 27.384 46.78 C
ATOM 300 O ILE 178 13.998 57.140 26.687 46.73 O
ATOM 301 N LEU 179 12.972 56.355 28.531 48.75 N
ATOM 302 CA LEU 179 14.166 55.716 29.069 51.49 C
ATOM 303 CB LEU 179 14.225 55.937 30.583 50.92 C
ATOM 304 CG LEU 179 13.934 57.367 31.049 51.57 C
ATOM 305 CDl LEU 179 14.133 57.460 32.552 51.88 C
ATOM 306 CD2 LEU 179 14.848 58.351 30.325 1.00 52.47 C
ATOM 307 C LEU 179 14.212 54.220 28.768 52.98 C
ATOM 308 O LEU 179 13.179 53.574 28.621 52.66 O
ATOM 309 N LYS 180 15.417 53.671 28.668 55.05 N
ATOM 310 CA LYS 180 15.568 52.246 28.403 56.95 C
ATOM 311 CB LYS 180 16.850 51.983 27.612 58.25 C
ATOM 312 CG LYS 180 16.784 52.418 26.156 59.29 C
ATOM 313 CD LYS 180 15.748 51.603 25.393 60.58 C
ATOM 314 CE LYS 180 15.657 52.043 23.940 60.70 C
ATOM 315 NZ LYS 180 16.974 51.914 23.258 61.17 N
ATOM 316 C LYS 180 15.617 51.500 29.728 57.68 C
ATOM 317 O LYS 180 16.520 51.722 30.534 57.26 O
ATOM 318 N LYS 181 14.639 50.628 29.959 58.93 N
ATOM 319 CA LYS 181 14.593 49.855 31.199 60.84 C
ATOM 320 CB LYS 181 13.490 48.792 31.138 60.92 C
ATOM 321 CG LYS 181 12.076 49.315 31.342 61.36 C
ATOM 322 CD LYS 181 11.102 48.155 31.498 62.16 C
ATOM 323 CE LYS 181 9.706 48.627 31.869 62.64 C
ATOM 324 NZ LYS 181 9.096 49.472 30.809 64.23 N
ATOM 325 C LYS 181 15.924 49.170 31.478 61.67 C
ATOM 326 O LYS 181 16.507 49.338 32.549 61.44 O
ATOM 327 N GLU 182 16.400 48.399 30.504 63.36 N
ATOM 328 CA GLU 182 17.657 47.671 30.642 64.98 C
ATOM 329 CB GLU 182 18.047 47.025 29.306 66.13 C
ATOM 330 CG GLU 182 17.127 45.887 28.854 67.77 C
ATOM 331 CD GLU 182 15.724 46.358 28.493 68.85 C
ATOM 332 OEl GLU 182 15.593 47.188 27.566 69.28 O
ATOM 333 OE2 GLU 182 14.754 45.895 29.133 68.76 O
ATOM 334 C GLU 182 18.810 48.537 31.147 65.27 C
ATOM 335 O GLU 182 19.752 48.029 31.754 65.34 O
ATOM 336 N VAL 183 18.738 49.841 30.902 65.66 N
ATOM 337 CA VAL 183 19.796 50.743 31.344 65.33 C
ATOM 338 CB VAL 183 19.836 52.030 30.485 65.64 C
ATOM 339 CGl VAL 183 21.023 52.892 30.892 65.72 C
ATOM 340 CG2 VAL 183 19.930 51.669 29.011 65.65 C
ATOM 341 C VAL 183 19.622 51.131 32.812 65.13 C
ATOM 342 O VAL 183 20.599 51.247 33.554 64.78 O
ATOM 343 N ILE 184 18.375 51.327 33.232 64.93 N
ATOM 344 CA ILE 184 18.087 51.699 34.615 64.41 C
ATOM 345 CB ILE 184 16.643 52.223 34.761 63.52 C
ATOM 346 CG2 ILE 184 16.332 52.494 36.224 63.83 C
ATOM 347 CGl ILE 184 16.471 53.504 33.942 1.00 62.77 C
ATOM 348 CDl ILE 184 15.091 54.114 34.037 62.42 C
ATOM 349 C ILE 184 18.278 50.506 35.551 64.98 C
ATOM 350 O ILE 184 18.518 50.673 36.748 64.91 O
ATOM 351 N ILE 185 18.173 49.305 34.991 65.70 N
ATOM 352 CA ILE 185 18.340 48.074 35.756 66.69 C
ATOM 353 CB ILE 185 17.600 46.895 35.096 65.94 C
ATOM 354 CG2 ILE 185 17.962 45.599 35.799 65.96 C
ATOM 355 CGl ILE 185 16.090 47.120 35.155 65.67 C
ATOM 356 CDl ILE 185 15.296 46.038 34.455 64.54 C
ATOM 357 C ILE 185 19.812 47.699 35.871 68.00 C
ATOM 358 O ILE 185 20.280 47.313 36.941 68.59 O
ATOM 359 N ALA 186 20.541 47.812 34.765 69.51 N
ATOM 360 CA ALA 186 21.962 47.479 34.757 70.68 C
ATOM 361 CB ALA 186 22.463 47.311 33.326 70.71 C
ATOM 362 C ALA 186 22.747 48.573 35.454 71.44 C
ATOM 363 O ALA 186 23.955 48.705 35.263 1.00 71.74 O ATOM 364 N LYS 187 22.050 49.371 36.254 00 72.36 N
ATOM 365 CA LYS 187 22.696 50.444 36.988 00 73.27 C
ATOM 366 CB LYS 187 22.515 51.776 36.257 00 74.15 C
ATOM 367 CG LYS 187 23.465 52.864 36.737 00 75.21 C
ATOM 368 CD LYS 187 24.922 52.404 36.637 00 76.12 C
ATOM 369 CE LYS 187 25.281 51.954 35.218 00 76.23 C
ATOM 370 NZ LYS 187 26.720 51.562 35.081 1.00 76.03 N
ATOM 371 C LYS 187 22.112 50.530 38.392 1.00 73.17 C
ATOM 372 O LYS 187 22.571 51.317 39.218 1.00 73.05 O
ATOM 373 N ASP 188 21.101 49.705 38.653 1.00 72.74 N
ATOM 374 CA ASP 188 20.448 49.671 39.956 1.00 72.16 C
ATOM 375 CB ASP 188 21.412 49.125 41.012 1.00 72.69 C
ATOM 376 CG ASP 188 20.898 49.320 42.427 1.00 73.36 C
ATOM 377 ODl ASP 188 19.837 48.753 42.766 1.00 72.73 O
ATOM 378 OD2 ASP 188 21.560 50.047 43.201 1.00 74.09 O
ATOM 379 C ASP 188 19.957 51.051 40.375 1.00 71.26 C
ATOM 380 O ASP 188 20.727 51.860 40.899 1.00 71.36 O
ATOM 381 N GLU 189 18.670 51.303 40.151 1.00 69.93 N
ATOM 382 CA GLU 189 18.053 52.578 40.495 1.00 68.25 C
ATOM 383 CB GLU 189 18.933 53.725 39.996 1.00 69.89 C
ATOM 384 CG GLU 189 18.493 55.122 40.393 1.00 71.45 C
ATOM 385 CD GLU 189 19.476 56.172 39.913 1.00 72.49 C
ATOM 386 OEl GLU 189 20.604 56.221 40.450 1.00 72.02 O
ATOM 387 OE2 GLU 189 19.128 56.937 38.988 1.00 73.72 O
ATOM 388 C GLU 189 16.673 52.651 39.851 66.38 C
ATOM 389 O GLU 189 16.282 53.680 39.299 66.21 O
ATOM 390 N VAL 190 15.941 51.543 39.922 64.22 N
ATOM 391 CA VAL 190 14.602 51.470 39.350 61.59 C
ATOM 392 CB VAL 190 14.246 50.016 38.956 61.78 C
ATOM 393 CGl VAL 190 15.268 49.477 37.966 61.52 C
ATOM 394 CG2 VAL 190 14.205 49.139 40.192 61.94 C
ATOM 395 C VAL 190 13.567 51.981 40.351 59.93 C
ATOM 396 O VAL 190 12.535 52.535 39.970 58.86 O
ATOM 397 N ALA 191 13.856 51.800 41.635 1.00 58.90 N
ATOM 398 CA ALA 191 12.954 52.238 42.695 00 57.95 C
ATOM 399 CB ALA 191 13.337 51.571 44.010 00 58.18 C
ATOM 400 C ALA 191 13.003 53.755 42.848 00 57.20 C
ATOM 401 O ALA 191 11.969 54.419 42.976 00 56.58 O
ATOM 402 N HIS 192 14.216 54.293 42.843 00 55.19 N
ATOM 403 CA HIS 192 14.412 55.723 42.975 00 54.22 C
ATOM 404 CB HIS 192 15.908 56.046 42.988 00 55.68 C
ATOM 405 CG HIS 192 16.207 57.505 43.129 00 56.72 C
ATOM 406 CD2 HIS 192 15.994 58.363 44.155 00 56.71 C
ATOM 407 NDl HIS 192 16.759 58.253 42.112 00 57.12 N
ATOM 408 CEl HIS 192 16.872 59.509 42.504 00 57.44 C
ATOM 409 NE2 HIS 192 16.414 59.604 43.739 1.00 57.46 N
ATOM 410 C HIS 192 13.723 56.434 41.816 1.00 51.99 C
ATOM 411 O HIS 192 13.108 57.484 41.994 00 52.37 O
ATOM 412 N THR 193 13.813 55.844 40.630 00 49.66 N
ATOM 413 CA THR 193 13.192 56.416 39.446 00 48.02 C
ATOM 414 CB THR 193 13.558 55.610 38.197 00 48.37 C
ATOM 415 OGl THR 193 14.981 55.611 38.037 00 49.45 0
ATOM 416 CG2 THR 193 12.917 56.220 36.960 00 48.49 C
ATOM 417 C THR 193 11.671 56.479 .39.575 00 47.06 C
ATOM 418 O THR 193 11.051 57.465 39.183 00 45.07 O
ATOM 419 N LEU 194 11.065 55.429 40.121 00 47.20 N
ATOM 420 CA LEU 194 9.615 55.421 40.291 00 47.72 C
ATOM 421 CB LEU 194 9.111 54.028 40.679 00 48.58 C
ATOM 422 CG LEU 194 9.079 52.975 39.568 00 49.46 C
ATOM 423 CDl LEU 194 8.399 51.719 40.088 00 49.91 C
ATOM 424 CD2 LEU 194 8.328 53.518 38.356 00 49.72 C
ATOM 425 C LEU 194 9.177 56.427 41.347 00 47.08 C
ATOM 426 O LEU 194 8.111 57.027 41.232 00 46.20 O
ATOM 427 N THR 195 10.000 56.614 42.373 00 47.28 N
ATOM 428 CA THR 195 9.670 57.556 43.437 00 48.40 C
ATOM 429 CB THR 195 10.588 57.369 44.666 00 48.76 C
ATOM 430 OGl THR 195 11.956 57.362 44.248 00 51.08 O
ATOM 431 CG2 THR 195 10.273 56.061 45.374 00 49.39 C
ATOM 432 C THR 195 9.751 59.008 42.970 1.00 47.70 C
ATOM 433 O THR 195 8.898 59.824 43.313 47.53 O
ATOM 434 N GLU 196 10.769 59.331 42.183 48.38 N
ATOM 435 CA GLU 196 10.918 60.693 41.685 49.33 C
ATOM 436 CB GLU 196 12.284 60.857 41.007 1.00 51.08 C ATOM 437 CG GLU 196 12.573 59.842 39.917 1.00 54.21 C
ATOM 438 CD GLU 196 14.044 59.801 39.528 1.00 57.08 C
ATOM 439 OEl GLU 196 14.378 59.124 38.530 1.00 58.18 O
ATOM 440 OE2 GLU 196 14.867 60.439 40.224 1.00 58.29 O
ATOM 441 C GLU 196 9.783 61.032 40.717 1.00 48.88 C
ATOM 442 O GLU 196 9.311 62.170 40.672 1.00 48.02 O
ATOM 443 N SER 197 9.340 60.042 39.949 1.00 48.02 N
ATOM 444 CA SER 197 8.246 60.250 39.006 1.00 48.40 C
ATOM 445 CB SER 197 8.030 58.996 38.159 1.00 49.36 C
ATOM 446 OG SER 197 7.742 57.875 38.978 1.00 49.82 O
ATOM 447 C SER 197 6.985 60.547 39.807 1.00 48.28 C
ATOM 448 O SER 197 6.184 61.415 39.451 1.00 47.67 O
ATOM 449 N ARG 198 6.827 59.808 40.895 1.00 48.31 N
ATOM 450 CA ARG 198 5.694 59.953 41.793 1.00 49.42 C
ATOM 451 CB ARG 198 5.876 58.981 42.957 1.00 50.86 C
ATOM 452 CG ARG 198 4.660 58.721 43.819 1.00 53.43 C
ATOM 453 CD ARG 198 5.052 57.715 44.897 1.00 55.56 C
ATOM 454 NK ARG 198 5.765 56.584 44.304 1.00 57.02 N
ATOM 455 CZ ARG 198 6.588 55.777 44.966 1.00 56.24 C
ATOM 455 NHl ARG 198 6.814 55.968 46.259 1.00 56.76 N
ATOM 457 NH2 ARG 198 7.184 54.775 44.334 1.00 56.63 N
ATOM 458 C ARG 198 5.674 61.391 42.308 1.00 48.76 C
ATOM 459 O ARG 198 4.633 62.055 42.323 1.00 49.94 O
ATOM 460 N VAL 199 6.845 61.859 42.726 1.00 46.79 N
ATOM 461 CA VAL 199 7.009 63.206 43.253 1.00 44.53 C
ATOM 462 CB VAL 199 8.470 63.444 43.685 1.00 43.84 C
ATOM 463 CGl VAL 199 8.705 64.919 43.954 1.00 42.56 C
ATOM 464 CG2 VAL 199 8.777 62.623 44.923 1.00 43.35 C
ATOM 465 C VAL 199 6.614 64.298 42.269 1.00 42.79 C
ATOM 466 O VAL 199 5.876 65.214 42.619 1.00 42.59 O
ATOM 467 N LEU 200 7.102 64.207 41.037 1.00 42.63 N
ATOM 468 CA LEU 200 6.797 65.227 40.034 1.00 42.97 C
ATOM 469 CB LEU 200 7.754 65.097 38.841 1.00 41.76 C
ATOM 470 CG LEU 200 9.206 65.438 39.181 1.00 40.29 C
ATOM 471 CDl LEU 200 10.088 65.305 37.946 1.00 40.48 C
ATOM 472 CD2 LEU 200 9.263 66.859 39.737 1.00 39.33 C
ATOM 473 C LEU 200 5.354 65.250 39.532 1.00 43.60 C
ATOM 474 O LEU 200 4.879 66.279 39.050 1.00 43.01 O
ATOM 475 N LYS 201 4.645 64.134 39.637 1.00 44.16 N
ATOM 47S CA LYS 201 3.271 64.128 39.158 1.00 45.55 C
ATOM 477 CB LYS 201 2.933 62.786 38.498 1.00 46.83 C
ATOM 478 CG LYS 201 3.163 61.558 39.350 1.00 47.16 C
ATOM 479 CD LYS 201 2.811 60.306 38.555 1.00 49.13 C
ATOM 480 CE LYS 201 1.398 60.401 37.992 1.00 49.89 C
ATOM 481 NZ LYS 201 1.013 59.198 37.204 1.00 51.10 N
ATOM 482 C LYS 201 2.258 64.459 40.239 1.00 45.46 C
ATOM 483 O LYS 201 1.120 64.820 39.941 1.00 46.72 O
ATOM 484 N ASN 202 2.677 64.362 41.494 1.00 45.36 N
ATOM 485 CA ASN 202 1.786 64.658 42.607 1.00 44.87 C
ATOM 486 CB ASN 202 1.853 63.535 43.638 1.00 45.90 C
ATOM 487 CG ASN 202 1.380 62.216 43.074 1.00 47.67 C
ATOM 488 ODl ASN 202 0.300 62.137 42.487 1.00 48.30 O
ATOM 489 ND2 ASN 202 2.184 61.171 43.244 1.00 48.54 N
ATOM 490 C ASN 202 2.081 65.993 43.282 1.00 44.28 C
ATOM 491 O ASN 202 1.547 66.286 44.351 1.00 43.56 O
ATOM 492 N THR 203 2.932 66.800 42.658 1.00 42.58 N
ATOM 493 CA THR 203 3.275 68.102 43.214 1.00 40.36 C
ATOM 494 CB THR 203 4.762 68.167 43.598 1.00 39.58 C
ATOM 495 OGl THR 203 5.553 67.647 42.522 1.00 38.40 O
ATOM 496 CG2 THR 203 5.025 67.365 44.868 1.00 38.13 C
ATOM 497 C THR 203 2.970 69.222 42.224 1.00 40.01 C
ATOM 498 O THR 203 2.915 69.001 41.019 1.00 40.63 O
ATOM 499 N ARG 204 2.765 70.423 42.748 1.00 39.60 N
ATOM 500 CA ARG 204 2.469 71.587 41.920 1.00 38.95 C
ATOM 501 CB ARG 204 0.962 71.863 41.885 1.00 41.75 C
ATOM 502 CG ARG 204 0.601 73.183 41.202 1.00 46.60 C
ATOM 503 CD ARG 204 -0.909 73.425 41.152 1.00 49.84 C
ATOM 504 NE ARG 204 -1.606 72.430 40.338 1.00 54.04 N
ATOM 505 CZ ARG 204 -2.898 72.491 40.022 1.00 56.02 C
ATOM 506 NHl ARG 204 -3.642 73.505 40.450 1.00 57.07 N
ATOM 507 NH2 ARG 204 -3.449 71.540 39.275 1.00 56.20 N
ATOM 508 C ARG 204 3.187 72.806 42.474 1.00 36.16 C
ATOM 509 O ARG 204 2.817 73.328 43.524 1.00 37.23 O ATOM 510 N HIS 205 4.207 73.259 41.755 1.00 34.10 N
ATOM 511 CA HIS 205 4.984 74.421 42.169 1.00 30.16 C
ATOM 512 CB HIS 205 6.177 73.988 43.017 1.00 28.06 C
ATOM 513 CG HIS 205 6.877 75.126 43.690 1.00 27.74 C
ATOM 514 CD2 HIS 205 7.887 75.924 43.273 1.00 25.38 C
ATOM 515 NDl HIS 205 6.498 75.603 44.925 1.00 25.50 N
ATOM 516 CEl HIS 205 7.244 76.644 45.242 1.00 23.85 C
ATOM 517 NE2 HIS 205 8.094 76.861 44.257 1.00 27.85 N
ATOM 518 C HIS 205 5.482 75.158 40.930 1.00 28.60 C
ATOM 519 O HIS 205 5.828 74.543 39.915 1.00 28.23 O
ATOM 520 N PRO 206 5.526 76.490 40.999 1.00 28.02 N
ATOM 521 CD PRO 206 5.102 77.325 42.138 1.00 29.13 C
ATOM 522 CA PRO 206 5.980 77.315 39.880 1.00 28.42 C
ATOM 523 CB PRO 206 6.015 78.722 40.480 1.00 29.29 C
ATOM 524 CG PRO 206 4.924 78.687 41.497 1.00 31.17 C
ATOM 525 C PRO 206 7.339 76.910 39.309 1.00 26.73 C
ATOM 526 O PRO 206 7.576 77.049 38.109 1.00 26.54 O
ATOM 527 N PHE 207 8.222 76.396 40.160 1.00 24.53 N
ATOM 528 CA PHE 207 9.560 76.041 39.717 1.00 24.46 C
ATOM 529 CB PHE 207 10.582 76.781 40.594 1.00 22.28 C
ATOM 530 CG PHE 207 10.302 78.258 40.713 1.00 22.74 C
ATOM 531 CDl PHE 207 10.196 79.049 39.580 1.00 19.86 C
ATOM 532 CD2 PHE 207 10.078 78.842 41.952 1.00 23.14 C
ATOM 533 CEl PHE 207 9.870 80.388 39.675 1.00 20.65 C
ATOM 534 CE2 PHE 207 9.748 80.185 42.056 1.00 22.67 C
ATOM 535 CZ PHE 207 9.644 80.960 40.909 1.00 21.29 C
ATOM 536 C PHE 207 9.881 74.551 39.642 1.00 25.58 C
ATOM 537 O PHE 207 11.044 74.166 39.562 1.00 26.13 O
ATOM 538 N LEU 208 8.844 73.717 39.663 1.00 26.88 N
ATOM 539 CA LEU 208 9.017 72.273 39.547 1.00 27.86 C
ATOM 540 CB LEU 208 8.373 71.544 40.730 1.00 28.82 C
ATOM 541 CG LEU 208 9.242 71.388 41.978 1.00 31.01 C
ATOM 542 CDl LEU 208 8.483 70.615 43.044 1.00 31.66 C
ATOM 543 CD2 LEU 208 10.528 70.664 41.607 1.00 31.51 C
ATOM 544 C LEU 208 8.365 71.801 38.252 1.00 28.27 C
ATOM 545 O LEU 208 7.216 72.140 37.975 1.00 28.45 O
ATOM 546 N THR 209 9.104 71.031 37.458 1.00 28.85 N
ATOM 547 CA THR 209 8.576 70.507 36.203 1.00 31.17 C
ATOM 548 CB THR 209 9.644 69.697 35.436 1.00 30.39 C
ATOM 549 OGl THR 209 10.754 70.544 35.119 1.00 35.13 O
ATOM 550 CG2 THR 209 9.063 69.137 34.149 1.00 33.42 C
ATOM 551 C THR 209 7.401 69.580 36.507 1.00 31.71 C
ATOM 552 O THR 209 7.538 68.636 37.282 1.00 33.40 O
ATOM 553 N SER 210 6.251 69.841 35.897 1.00 32.46 N
ATOM 554 CA SER 210 5.074 69.005 36.129 1.00 33.95 C
ATOM 555 CB SER 210 3.805 69.833 35.916 1.00 35.83 C
ATOM 556 OG SER 210 2.646 69.027 36.052 1.00 41.22 O
ATOM 557 C SER 210 5.044 67.758 35.233 1.00 33.30 C
ATOM 558 O SER 210 5.342 67.825 34.042 1.00 31.97 O
ATOM 559 N LEU 211 4.696 66.619 35.821 1.00 33.09 N
ATOM 560 CA LEU 211 4.619 65.366 35.077 1.00 36.84 C
ATOM 561 CB LEU 211 5.212 64.230 35.915 1.00 36.18 C
ATOM 562 CG LEU 211 5.402 62.842 35.305 1.00 38.18 C
ATOM 563 CDl LEU 211 6.196 62.002 36.282 1.00 40.45 C
ATOM 564 CD2 LEU 211 4.068 62.184 35.008 1.00 38.53 C
ATOM 565 C LEU 211 3.147 65.101 34.771 1.00 38.08 C
ATOM 566 O LEU 211 2.366 64.811 35.671 1.00 39.09 O
ATOM 567 N LYS 212 2.775 65.209 33.499 1.00 41.01 N
ATOM 568 CA LYS 212 1.389 65.011 33.079 1.00 43.53 C
ATOM 569 CB LYS 212 1.181 65.602 31.683 1.00 44.86 C
ATOM 570 CG LYS 212 -0.268 65.637 31.214 1.00 46.42 C
ATOM 571 CD LYS 212 -1.054 66.727 31.924 1.00 47.09 C
ATOM 572 CE LYS 212 -2.470 66.832 31.375 1.00 48.42 C
ATOM 573 NZ LYS 212 -3.169 68.050 31.874 1.00 48.56 N
ATOM 574 C LYS 212 0.964 63.545 33.070 1.00 45.40 C
ATOM 575 O LYS 212 o.oos 63.162 33.742 1.00 45.65 O
ATOM 576 N TYR 213 1.676 62.726 32.307 1.00 46.57 N
ATOM 577 CA TYR 213 1.341 61.312 32.210 1.00 49.28 C
ATOM 578 CB TYR 213 0.644 61.023 30.878 1.00 48.98 C
ATOM 579 CG TYR 213 -0.475 61.970 30.504 1.00 48.76 C
ATOM 580 CDl TYR 213 -1.596 62.116 31.311 1.00 49.01 C
ATOM 581 CEl TYR 213 -2.639 62.952 30.941 1.00 50.04 C
ATOM 582 CD2 TYR 213 -0.427 62.690 29.314 1.00 48.55 C ATOM 583 CE2 TYR 213 -1.460 63.520 28.935 1.00 49.04 C
ATOM 584 CZ TYR 213 -2.565 63.650 29.750 1.00 50.41 C
ATOM 585 OH TYR 213 -3.598 64.475 29.364 1.00 51.32 O
ATOM 58S C TYR 213 2.582 60.435 32.299 1.00 51.26 C
ATOM 587 O TYR 213 3.707 60.916 32.164 1.00 51.19 O
ATOM 588 N SiER 214 2.370 59.140 32.516 1.00 53.87 N
ATOM 589 CA SER 214 3.475 58.190 32.593 1.00 57.46 C
ATOM 590 CB SER 214 4.036 58.129 34.016 1.00 56.94 C
ATOM 591 OG SER 214 3.074 57.621 34.925 1.00 57.48 O
ATOM 592 C SER 214 3.021 56.798 32.163 1.00 60.10 C
ATOM 593 O SER 214 3.005 55.869 32.970 1.00 61.84 O
ATOM 594 N PHE 215 2.656 56.648 30.894 1.00 62.23 N
ATOM 595 CA PHE 215 2.207 55.349 30.411 1.00 63.79 C
ATOM 596 CB PHE 215 1.741 55.421 28.955 1.00 63.76 C
ATOM 597 CG PHE 215 2.759 55.975 28.006 1.00 63.86 C
ATOM 598 CDl PHE 215 3.043 57.329 27.985 1.00 63.65 C
ATOM 599 CD2 PHE 215 3.394 55.147 27.096 1.00 63.89 C
ATOM 600 CEl PHE 215 3.938 57.849 27.071 1.00 63.61 C
ATOM 601 CE2 PHE 215 4.291 55.662 26.178 1.00 63.99 C
ATOM 602 CZ PHE 215 4.561 57.015 26.166 1.00 63.54 C
ATOM 603 C PHE 215 3.274 54.278 30.557 1.00 65.52 C
ATOM 604 O PHE 215 4.471 54.571 30.620 1.00 65.09 O
ATOM 605 N GLN 216 2.816 53.032 30.603 1.00 67.87 N
ATOM 606 CA GLN 216 3.685 51.880 30.780 1.00 69.70 C
ATOM 607 CB GLN 216 2.864 50.678 31.262 1.00 70.40 C
ATOM 608 CG GLN 216 2.061 50.912 32.539 1.00 71.31 C
ATOM 609 CD GLN 216 0.693 51.529 32.284 1.00 71.75 C
ATOM 610 OEl GLN 216 0.581 52.644 31.772 1.00 71.75 O
ATOM 611 NE2 GLN 216 -0.357 50.800 32.646 1.00 71.83 N
ATOM 612 C GLN 216 4.474 51.478 29.542 1.00 70.46 C
ATOM 613 O GLN 216 5.573 51.981 29.306 1.00 70.37 O
ATOM 614 N THR 217 3.902 50.566 28.760 1.00 71.52 N
ATOM 615 CA THR 217 4.555 50.055 27.561 1.00 72.61 C
ATOM 616 CB THR 217 4.604 51.111 26.443 1.00 72.88 C
ATOM 617 OGl THR 217 3.272 51.542 26.136 1.00 72.81 O
ATOM 618 CG2 THR 217 5.235 50.523 25.187 1.00 71.79 C
ATOM 619 C THR 217 5.970 49.659 27.964 1.00 73.21 C
ATOM 620 O THR 217 6.912 50.442 27.837 1.00 73.81 O
ATOM 621 N LYS 218 6.096 48.435 28.468 1.00 73.65 N
ATOM 622 CA LYS 218 7.367 47.895 28.936 1.00 73.52 C
ATOM 623 CB LYS 218 7.223 46.390 29.184 1.00 74.25 C
ATOM 624 CG LYS 218 5.960 46.018 29.960 1.00 75.15 C
ATOM 625 CD LYS 218 5.901 46.695 31.325 1.00 75.33 C
ATOM 626 CE LYS 218 6.979 46.169 32.265 1.00 75.90 C
ATOM 627 NZ LYS 218 6.918 46.811 33.615 1.00 75.25 N
ATOM 628 C LYS 218 8.534 48.158 27.985 1.00 72.78 C
ATOM 629 O LYS 218 8.336 48.398 26.792 1.00 72.68 O
ATOM 630 N ASP 219 9.744 48.105 28.541 1.00 71.88 N
ATOM 631 CA ASP 219 10.991 48.337 27.808 1.00 70.29 C
ATOM 632 CB ASP 219 10.939 47.720 26.411 1.00 70.29 C
ATOM 633 CG ASP 219 12.156 48.082 25.577 1.00 70.88 C
ATOM 634 ODl ASP 219 13.273 47.650 25.939 1.00 70.61 O
ATOM 635 OD2 ASP 219 12.001 48.809 24.569 1.00 69.99 O
ATOM 636 C ASP 219 11.304 49.820 27.669 1.00 69.10 C
ATOM 637 O ASP 219 12.450 50.244 27.832 1.00 68.73 O
ATOM 638 N ARG 220 10.279 50.607 27.365 1.00 68.03 N
ATOM 639 CA ARG 220 10.455 52.037 27.192 1.00 66.95 C
ATOM 640 CB ARG 220 9.586 52.543 26.031 1.00 68.39 C
ATOM 641 CG ARG 220 8.468 51.602 25.584 1.00 70.29 C
ATOM 642 CD ARG 220 9.005 50.407 24.797 1.00 71.88 C
ATOM 643 NE ARG 220 7.931 49.588 24.237 1.00 73.35 N
ATOM 644 CZ ARG 220 8.122 48.502 23.490 1.00 73.87 C
ATOM 645 NHl ARG 220 9.352 48.093 23.208 1.00 73.48 N
ATOM 646 NH2 ARG 220 7.081 47.829 23.017 1.00 74.20 N
ATOM 647 C ARG 220 10.177 52.865 28.442 1.00 65.59 C
ATOM 648 O ARG 220 10.999 53.690 28.823 1.00 66.57 O
ATOM 649 N LEU 221 9.034 52.650 29.085 1.00 63.01 N
ATOM 650 CA LEU 221 8.682 53.425 30.278 1.00 59.99 C
ATOM 651 CB LEU 221 9.609 53.074 31.441 1.00 61.76 C
ATOM 652 CG LEU 221 9.023 53.254 32.845 1.00 63.27 C
ATOM 653 CDl LEU 221 10.122 53.047 33.874 1.00 64.19 C
ATOM 654 CD2 LEU 221 8.415 54.636 32.991 1.00 63.67 C
ATOM 655 C LEU 221 8.846 54.898 29.908 1.00 56.96 C ATOM 656 O LEU 221 .962 55.417 29.839 1.00 54.86 O
ATOM 657 N CYS 222 .731 55.579 29.684 1.00 54.18 N
ATOM 658 CA CYS 222 . 7.794 56.968 29.269 1.00 51.47 C
ATOM 659 CB CYS 222 7.208 57.073 27.868 1.00 52.07 C
ATOM 660 SG CYS 222 7.606 55.624 26.859 1.00 53.08 S
ATOM 661 C CYS 222 7.105 57.957 30.200 48.97 C
ATOM 662 O CYS 222 6.086 57.645 30.818 47.22 O
ATOM 663 N PHE 223 7.671 59.159 30.277 46.25 N
ATOM 664 CA PHE 223 7.137 60.217 31.125 43.11 C
ATOM 665 CB PHE 223 8.134 60.548 32.241 44.18 C
ATOM 666 CG PHE 223 8.456 59.383 33.142 45.27 C
ATOM 667 CDl PHE 223 7.449 58.703 33.811 44.84 C
ATOM 668 CD2 PHE 223 9.772 58.993 33.348 45.89 C
ATOM 669 CEl PHE 223 7.750 57.659 34.672 1.00 45.66 C
ATOM 670 CE2 PHE 223 10.082 57.950 34.207 46.00 C
ATOM 671 CZ PHE 223 9.070 57.284 34.871 45.97 C
ATOM 672 C PHE 223 6.830 61.486 30.326 40.76 C
ATOM 673 O PHE 223 7.721 62.088 29.726 39.44 O
ATOM 674 N VAL 224 5.563 61.884 30.325 37.99 N
ATOM 675 CA VAL 224 5.133 63.079 29.615 1.00 36.18 C
ATOM 676 CB VAL 224 3.685 62.944 29.115 .00 35.68 C
ATOM 677 CGl VAL 224 3.265 64.209 28.389 .00 35.37 C
ATOM 678 CG2 VAL 224 3.569 61.740 28.201 .00' 35.55 C
ATOM 679 C VAL 224 5.217 64.246 30.583 .00 35.26 C
ATOM 680 O VAL 224 4.483 64.297 31.572 .00 35.82 O
ATOM 681 N MET 225 6.110 65.184 30.287 00 33.97 N
ATOM 682 CA MET 225 6.328 66.338 31.147 .00 33.58 C
ATOM 683 CB MET 225 7.712 66.222 31.788 .00 35.60 C
ATOM 684 CG MET 225 7.943 64.895 32.482 1.00 37.83 C
ATOM 685 SD MET 225 9.689 64.595 32.771 1.00 44.39 S
ATOM 686 CE MET 225 9.858 65.234 34.431 1.00 42.52 C
ATOM 687 C MET 225 6.224 67.689 30.450 1.00 33.09 C
ATOM 688 O MET 225 6.234 67.779 29.221 1.00 31.36 O
ATOM 689 N GLU 226 6.131 68.732 31.269 1.00 33.43 N
ATOM 690 CA GLU 226 6.054 70.121 30.825 00 34.79 C
ATOM 691 CB GLU 226 6.206 71.030 32.043 00 36.47 C
ATOM 692 CG GLU 226 5.451 72.338 31.997 00 38.87 C
ATOM 693 CD GLU 226 5.779 73.215 33.191 00 38.56 C
ATOM 694 OEl GLU 226 5.913 72.675 34.316 00 36.00 O
ATOM 695 OE2 GLU 226 5.898 74.444 33.007 00 41.80 O
ATOM 696 C GLU 226 7.228 70.349 29.869 00 35.25 C
ATOM 697 O GLU 226 8.338 69.907 30.141 00 33.50 O
ATOM 698 N TYR 227 7.001 71.051 28.765 00 36.20 N
ATOM 699 CA TYR 227 8.077 71.272 27.800 00 37.33 C
ATOM 700 CB TYR 227 7.484 71.848 26.510 00 36.69 C
ATOM 701 CG TYR 227 8.503 72.128 25.437 00 36.04 C
ATOM 702 CDl TYR 227 9.568 71.270 25.225 00 35.39 C
ATOM 703 CEl TYR 227 10.519 71.543 24.264 00 37.41 C
ATOM 704 CD2 TYR 227 8.410 73.264 24.649 00 36.82 C
ATOM 705 CE2 TYR 227 9.354 73.542 23.679 00 37.19 C
ATOM 706 CZ TYR 227 10.407 72.681 23.494 1.00 37.44 C
ATOM 707 OH TYR 227 11.372 72.970 22.556 1.00 37.67 O
ATOM 708 C TYR 227 9.312 72.088 28.265 37.82 C
ATOM 709 O I TYR 227 10.404 71.527 28.377 41.20 O
ATOM 710 N VAL 228 9.171 73.386 28.516 37.40 N
ATOM 711 CA VAL 228 10.319 74.201 28.972 36.61 C
ATOM 712 CB VAL 228 10.902 73.652 30.304 37.38 C
ATOM 713 CGl VAL 228 12.052 74.520 30.775 36.69 C
ATOM 714 CG2 VAL 228 9.814 73.602 31.365 38.80 C
ATOM 715 C VAL 228 11.454 74.256 27.939 35.22 C
ATOM 716 O VAL 228 12.209 73.296 27.781 33.48 O
ATOM 717 N ASN 229 11.588 75.394 27.261 34.81 N
ATOM 718 CA ASN 229 12.600 75.543 26.211 1.00 34.97 C
ATOM 719 CB ASN 229 11.911 75.675 24.838 35.18 C
ATOM 720 CG ASN 229 11.074 76.944 24.714 37.37 C
ATOM 721 ODl ASN 229 10.760 77.386 23.608 39.07 O
ATOM 722 ND2 ASN 229 10.701 77.528 25.847 35.64 N
ATOM 723 C ASN 229 13.590 76.701 26.374 33.98 C
ATOM 724 O ASN 229 14.035 77.281 25.382 31.88 O
ATOM 725 N GLY 230 13.943 77.026 27.611 31.35 N
ATOM 726 CA GLY 230 14.875 78.114 27.841 31.85 C
ATOM 727 C GLY 230 16.310 77.637 27.923 31.17 C
ATOM 728 O GLY 230 17.232 78.438 28.107 1.00 31.76 O ATOM 729 N GLY 231 16.495 76.325 27.810 30.49 N
ATOM 730 CA GLY 231 17.829 75.754 27.842 31.37 C
ATOM 731 C GLY 231 18.324 75.246 29.182 33.14 C
ATOM 732 O GLY 231 17.853 75.676 30.238 32.28 O
ATOM 733 N GLU 232 19.283 74.323 29.122 33.93 N
ATOM 734 CA GLU 232 19.910 73.727 30.304 35.35 C
ATOM 735 CB GLU 232 20.735 72.501 29.902 38.36 C
ATOM 736 CG GLU 232 19.959 71.220 29.661 42.64 C
ATOM 737 CD GLU 232 20.006 70.287 30.860 46.47 C
ATOM 738 OEl GLU 232 19.300 70.558 31.854 47.51 O
ATOM 739 OE2 GLU 232 20.762 69.290 30.811 46.80 O
ATOM 740 C GLU 232 20.848 74.728 30.977 33.97 C
ATOM 741 O GLU 232 21.668 75.350 30.310 1.00 32.58 O
ATOM 742 N LEU 233 20.742 74.874 32.293 33.50 N
ATOM 743 CA LEU 233 21.612 75.802 33.008 34.83 C
ATOM 744 CB LEU 233 21.207 75.912 34.482 34.80 C
ATOM 74S CG LEU 233 20.196 77.024 34.748 37.79 C
ATOM 746 CDl LEU 233 19.747 77.004 36.200 40.16 C
ATOM 747 CD2 LEU 233 20.843 78.362 34.398 38.05 C
ATOM 748 C LEU 233 23.052 75.345 32.901 34.83 C
ATOM 749 O LEU 233 23.972 76.155 32.949 37.04 O
ATOM 750 N PHE 234 23.247 74.039 32.764 35.76 N
ATOM 751 CA PHE 234 24.591 73.500 32.624 38.72 C
ATOM 752 CB PHE 234 24.525 71.973 32.509 41.06 C
ATOM 753 CG PHE 234 25.866 71.300 32.560 44.09 C
ATOM 754 CDl PHE 234 26.772 71.441 31.519 46.13 C
ATOM 755 CD2 PHE 234 26.229 70.538 33.659 45.13 C
ATOM 756 CEl PHE 234 28.018 70.833 31.574 46.77 C
ATOM 757 CE2 PHE 234 27.471 69.929 33.721 46.57 C
ATOM 758 CZ PHE 234 28.367 70.078 32.675 46.54 C
ATOM 759 C PHE 234 25.177 74.119 31.349 37.98 C
ATOM 760 O PHE 234 26.325 74.559 31.319 38.06 O
ATOM 761 N PHE 235 24.357 74.177 30.307 1.00 38.94 N
ATOM 762 CA PHE 235 24.763 74.739 29.023 38.45 C
ATOM 763 CB PHE 235 23.663 74.476 27.991 41.82 C
ATOM 764 CG PHE 235 23.920 75.099 26.648 45.53 C
ATOM 765 CDl PHE 235 23.407 76.348 26.339 47.45 C
ATOM 766 CD2 PHE 235 24.660 74.427 25.689 47.38 C
ATOM 767 CEl PHE 235 23.622 76.912 25.100 48.45 C
ATOM 768 CE2 PHE 235 24.882 74.987 24.446 47.32 C
ATOM 769 CZ PHE 235 24.361 76.230 24.152 49.20 C
ATOM 770 C PHE 235 25.053 76.235 29.131 36.60 C
ATOM 771 O PHE 235 26.096 76.714 28.678 35.05 O
ATOM 772 N HIS 236 24.131 76.970 29.740 34.75 N
ATOM 773 CA HIS 236 24.309 78.405 29.919 34.04 C
ATOM 774 CB HIS 236 23.114 79.003 30.659 32.99 C
ATOM 775 CG HIS 236 21.855 79.019 29.855 32.64 C
ATOM 776 CD2 HIS 236 20.701 78.324 29.988 32.07 C
ATOM 777 NDl HIS 236 21.693 79.818 28.743 32.75 N
ATOM 778 CEl HIS 236 20.496 79.613 28.228 33.63 C
ATOM 779 NE2 HIS 236 19.873 78.710 28.966 32.98 N
ATOM 780 C HIS 236 25.581 78.707 30.697 33.99 C
ATOM 781 O HIS 236 26.376 79.554 30.283 33.65 O
ATOM 782 N LEU 237 25.777 78.014 31.819 34.13 H
ATOM 783 CA LEU 237 26.956 78.243 32.651 34.93 C
ATOM 784 CB LEU 237 26.870 77.443 33.955 33.24 C
ATOM 785 CG LEU 237 27.981 77.713 34.976 33.21 C
ATOM 786 CDl LEU 237 27.892 79.160 35.467 32.43 C
ATOM 787 CD2 LEU 237 27.844 76.753 36.155 32.23 C
ATOM 788 C LEU 237 28.237 77.879 31.916 36.96 C
ATOM 789 O LEU 237 29.286 78.460 32.175 36.20 O
ATOM 790 N SER 238 28.144 76.916 31.003 41.35 N
ATOM 791 CA SER 238 29.297 76.477 30.214 44.05 C
ATOM 792 CB SER 238 28.901 75.326 29.289 44.54 C
ATOM 793 OG SER 238 28.385 74.240 30.027 49.74 O
ATOM 794 C SER 238 29.828 77.619 29.359 45.27 C
ATOM 795 O SER 238 31.022 77.926 29.374 47.12 O
ATOM 796 N ARG 239 28.922 78.237 28.611 45.85 N
ATOM 797 CA ARG 239 29.252 79.341 27.720 45.76 C
ATOM 798 CB ARG 239 28.032 79.701 26.874 48.76 C
ATOM 799 CG ARG 239 27.338 78.517 26.246 51.87 C
ATOM 800 CD ARG 239 26.061 78.934 25.526 55.58 C
ATOM 801 NE ARG 239 25.042 79.487 26.419 1.00 59.80 N ATOM 802 CZ ARG 239 24.970 80.764 26.786 1.00 60.80 C
ATOM 803 NHl ARG 239 25.859 81.638 26.336 1.00 61.57 N
ATOM 804 NH2 ARG 239 24.004 81.170 27.599 1.00 61.26 N
ATOM 805 C ARG 239 29.701 80.591 28.455 1.00 44.55 C
ATOM 806 O ARG 239 30.590 81.303 27.999 1.00 44.71 O
ATOM 807 N GLU 240 29.075 80.869 29.590 1.00 43.24 N
ATOM 808 CA GLU 240 29.407 82.070 30.341 1.00 41.41 C
ATOM 809 CB GLU 240 28.150 82.593 31.031 1.00 42.73 C
ATOM 810 CG GLU 240 26.985 82.760 30.075 1.00 46.34 C
ATOM 811 CD GLU 240 25.772 83.364 30.737 1.00 48.24 C
ATOM 812 OEl GLU 240 25.873 84.512 31.220 1.00 50.69 O
ATOM 813 OE2 GLU 240 24.716 82.691 30.771 1.00 50.46 O
ATOM 814 C GLU 240 30.522 81.866 31.356 1.00 38.99 C
ATOM 815 O GLU 240 31.107 82.830 31.840 1.00 38.29 O
ATOM 816 N ARG 241 30.808 80.604 31.659 1.00 38.53 N
ATOM 817 CA ARG 241 31.844 80.221 32.615 1.00 37.42 C
ATOM 818 CB ARG 241 33.162 80.932 32.282 1.00 39.76 C
ATOM 819 CG ARG 241 33.649 80.695 30.852 1.00 44.64 C
ATOM 820 CD ARG 241 34.173 79.273 30.624 1.00 48.84 C
ATOM 821 NE ARG 241 33.224 78.236 31.030 1.00 54.00 N
ATOM 822 CZ ARG 241 33.404 76.933 30.830 1.00 55.39 C
ATOM 823 NHl ARG 241 34.501 76.498 30.220 1.00 56.87 N
ATOM 824 NH2 ARG 241 32.495 76.063 31.251 1.00 55.50 N
ATOM 825 C ARG 241 31.444 80.498 34.066 1.00 35.01 C
ATOM 826 O ARG 241 31.646 79.657 34.943 1.00 34.11 O
ATOM 827 N VAL 242 30.873 81.674 34.312 1.00 33.84 N
ATOM 828 CA VAL 242 30.446 82.065 35.654 1.00 31.95 C
ATOM 829 CB VAIi 242 31.571 82.817 36.393 1.00 32.90 C
ATOM 830 CGl VAL 242 31.118 83.201 37.779 1.00 32.45 C
ATOM 831 CG2 VAL 242 32.816 81.946 36.476 1.00 36.07 C
ATOM 832 C VAL 242 29.230 82.987 35.599 1.00 30.46 C
ATOM 833 O VAL 242 29.055 83.736 34.645 1.00 30.59 O
ATOM 834 N PHE 243 28.381 82.918 36.618 1.00 29.42 N
ATOM 835 CA PHE 243 27.212 83.792 36.692 1.00 27.19 C
ATOM 836 CB PHE 243 25.959 83.035 37.163 1.00 26.71 C
ATOM 837 CG PHE 243 25.443 82.010 36.196 1.00 27.39 C
ATOM 838 CDl PHE 243 25.649 82.141 34.832 1.00 27.79 C
ATOM 839 CD2 PHE 243 24.670 80.949 36.652 1.00 28.47 C
ATOM 840 CEl PHE 243 25.090 81.240 33.949 1.00 28.24 C
ATOM 841 CE2 PHE 243 24.105 80.043 35.774 1.00 28.26 C
ATOM 842 CZ PHE 243 24.315 80.190 34.414 1.00 29.18 C
ATOM 843 C PHE 243 27.543 84.847 37.746 1.00 25.74 C
ATOM 844 O PHE 243 28.338 84.589 38.653 1.00 27.05 O
ATOM 845 N SER 244 26.935 86.024 37.636 1.00 24.07 N
ATOM 846 CA SER 244 27.156 87.067 38.620 1.00 24.04 C
ATOM 847 CB SER 244 26.538 88.383 38.156 1.00 23.61 C
ATOM 848 OG SER 244 25.127 88.270 38.072 1.00 24.80 O
ATOM 849 C SER 244 26.463 86.601 39.906 1.00 24.42 C
ATOM 850 O SER 244 25.655 85.662 39.880 1.00 20.80 O
ATOM 851 N GLU 245 26.778 87.243 41.024 1.00 24.88 N
ATOM 852 CA GLU 245 26.152 86.860 42.279 1.00 26.41 C
ATOM 853 CB GLU 245 26.799 87.596 43.454 1.00 25.28 C
ATOM 854 CG GLU 245 28.287 87.300 43.607 1.00 29.71 C
ATOM 855 CD GLU 245 28.840 87.733 44.950 1.00 30.67 C
ATOM 856 OEl GLU 245 30.081 87.817 45.078 1.00 27.68 O
ATOM 857 OE2 GLU 245 28.036 87.974 45.883 1.00> 30.85 O
ATOM 858 C GLU 245 24.662 87.189 42.201 1.00 26.78 C
ATOM 859 O GLU 245 23.831 86.485 42.773 1.00 23.99 O
ATOM 860 N ASP 246 24.328 88.253 41.475 1.00 25.98 N
ATOM 861 CA ASP 246 22.933 88.636 41.340 1.00 26.82 C
ATOM 862 CB ASP 246 22.802 89.980 40.641 1.00 30.85 C
ATOM 863 CG ASP 246 22.140 91.014 41.510 1.00 35.92 C
ATOM 864 ODl ASP 246 21.043 90.723 42.053 1.00 36.24 O
ATOM 865 OD2 ASP 246 22.716 92.116 41.652 1.00 37.77 O
ATOM 866 C ASP 246 22.147 87.595 40.563 1.00 26.59 C
ATOM 867 O ASP 246 21.014 87.270 40.936 1.00 24.92 O
ATOM 868 N ARG 247 22.730 87.082 39.479 1.00 25.40 N
ATOM 869 CA ARG 247 22.030 86.077 38.684 1.00 26.81 C
ATOM 870 CB ARG 247 22.742 85.750 37.362 1.00 27.43 C
ATOM 871 CG ARG 247 21.845 84.842 36.510 1.00 32.11 C
ATOM 872 CD ARG 247 22.542 83.970 35.475 1.00 37.50 C
ATOM 873 NE ARG 247 22.923 84.673 34.261 1.00 40.70 N
ATOM 874 CZ ARG 247 22.817 84.166 33.035 1.00 40.73 C ATOM 875 NHl ARG 247 22.326 82.948 32.842 1.00 38.94 N ATOM 876 NH2 ARG 247 23.228 84.876 31.997 1.00 43.23 N ATOM 877 C ARG 247 21.893 84.794 39.481 1.00 25.74 C ATOM 8 87788 O O ARG 247 20.853 84.127 39.418 1.00 23.99 O ATOM 8 87799 N N THR 248 22.944 84.454 40.226 1.00 21.14 N ATOM 8 88800 CCAA THR 248 22.942 83.250 41.045 00 23.01 C ATOM 8 88811 CCBB THR 248 24.354 82.964 41.624 00 22.88 C ATOM 882 OGl THR 248 25.295 82.854 40.543 ,00 24.25 O ATOM 883 CG2 THR 248 24.348 81.649 42.426 1. 00 20 .47 C ATOM 8 88844 C THR 248 21.923 83.364 42.179 1 . 00 22 . 32 C ATOM 888855 O THR 248 21.272 82.377 42.524 1 . 00 24 . 11 O ATOM 886 N ARG 249 21.775 84.563 42.743 1. 00 22 . 32 N ATOM 887 CA ARG 249 20.805 84.795 43.813 1 . 00 22 . 76 C ATOM 8 88888 CB ARG 249 20.931 86.221 44.374 1 . 00 24 . 57 C ATOM 888899 CG ARG 249 19.795 86.619 45.347 1 . 00 25 .31 C ATOM 890 CD ARG 249 20.188 87.834 46.192 00 29 .41 C ATOM 891 NE ARG 249 20.932 88.769 45.374 1.00 3 333..7711 N ATOM 892 CZ ARG 249 22.162 89.202 45.632 1.00 30.63 C ATOM 893 NHl ARG 249 22.826 88.812 46.721 1.00 26.46 N ATOM 894 NH2 ARG 249 22.753 89.985 44.749 1.00 30.05 N ATOM 8 89955 C ARG 249 19.381 84.571 43.299 1.00 21.62 C ATOM 889966 O A ARRGG 249 18.551 83.994 43.998 1.00 20.58 O ATOM 889977 N PPHHEE 250 19.114 85.039 42.084 1.00 22.02 N ATOM 898 CA PHE 250 17.802 84.883 41.448 1.00 21.84 C ATOM 8 89999 CCBB PHE 250 17.811 85.557 40.064 1.00 23.42 C ATOM 9 90000 CCGG PHE 250 16.577 85.276 39.244 1.00 23.04 C ATOM 901 CDl PHE 250 15.429 86.036 39.406 1.00 26.88 C ATOM 902 CD2 PHE 250 16.549 84.210 38.362 1.00 23.41 C ATOM 903 CEl PHE 250 14.267 85.725 38.698 1.00 26.96 C ATOM 904 CE2 PHE 250 15.392 83.897 37.653 1.00 26.29 C ATOM 905 CZ PHE 250 14.256 84.654 37.825 1.00 22.33 C ATOM 9 90066 C C P P PHHHEEE 250 17.457 83.387 41.301 1.00 20.63 C ATOM 907 O P PHHEE 250 16.387 82.930 41.737 1.00 19.70 O ATOM 908 N T TYYRR 251 18.356 82.621 40.690 1.00 19.23 N ATOM 909 CA TYR 251 18.128 81.180 40.520 1.00 20.97 C ATOM 910 CB TYR 251 19.262 80.533 39.707 1.00 21.37 C ATOM 911 CG TYR 251 19.341 81.025 38.280 1.00 23.26 C ATOM 912 CDl TYR 251 18.190 81.384 37.592 1.00 23.55 C ATOM 913 CEl TYR 251 18.239 81.844 36.288 1.00 22.60 C ATOM 914 CD2 TYR 251 20.560 81.133 37.620 1.00 24.68 C ATOM 915 CE2 TYR 251 20.621 81.592 36.304 1.00 25.22 C ATOM 916 CZ TYR 251 19.453 81.947 35.649 1.00 24.17 C ATOM 917 OH TYR 251 19.495 82.412 34.357 1.00 22.75 O ATOM 918 C TYR 251 18.024 80.481 41.876 1.00 20.80 C ATOM 919 O TYR 251 17.147 79.643 42.092 1.00 20.48 O ATOM 920 N GLY 252 18.924 80.841 42.781 1.00 20.60 N ATOM 921 CA GLY 252 18.941 80.256 44.113 1.00 22.32 C ATOM 922 C GLY 252 17.652 80.473 44.889 1.00 19.59 C ATOM 923 O GLY 252 17.165 79.564 45.562 1.00 20.67 O ATOM 924 N ALA 253 17.105 81.679 44.800 1.00 20.56 N ATOM 925 CA ALA 253 15.865 82.001 45.492 1.00 20.33 C ATOM 926 CB ALA 253 15.545 83.474 45.327 1.00 20.45 C ATOM 927 C ALA 253 14.710 81.145 44.961 1.00 20.97 C ATOM 9 92288 O A ALLAA 253 13.867 80.672 45.730 1.00 19.82 O ATOM 9 92299 N GGLLUU 254 14.669 80.932 43.649 1.00 21.84 N ATOM 930 CA GLU 254 13.589 80.125 43.093 1.00 21.74 C ATOM 931 CB GLU 254 13.527 80.307 41.570 1.00 20.61 C ATOM 932 CG GLU 254 13.297 81.784 41.188 1.00 24.72 C ATOM 933 CD GLU 254 12.820 81.996 39.756 1.00 24.02 C ATOM 934 OEl GLU 254 13.267 81.270 38.849 1.00 25.51 O ATOM 935 OE2 GLU 254 12.001 82.916 39.537 1.00 28.43 O ATOM 936 C GLU 254 13.727 78.655 43.497 1.00 20.57 C ATOM 937 O G GLLUU 254 12.726 77.965 43.732 1.00 19.26 O ATOM 938 N IILLEE 255 14.963 78.178 43.617 1.00 20.32 N ATOM 939 CA ILE 255 15.187 76.799 44.032 1.00 20.54 C ATOM 940 CB ILE 255 16.679 76.408 43.866 1.00 20.12 C ATOM 941 CG2 ILE 255 16.949 75.044 44.501 1.00 21.99 C ATOM 942 CGl ILE 255 17.030 76.381 42.373 1.00 22.31 C ATOM 943 CDl ILE 255 18.507 76.189 42.071 1.00 21.99 C ATOM 9 94444 C ILE 255 14.760 76.667 45.498 1.00 21.72 C ATOM 994455 O ILE 255 14.081 75.706 45.884 1.00 21.82 O ATOM 994466 N VAL 256 15.134 77.649 46.307 1 . 00 20 .46 N ATOM 947 CA VAL 256 14.774 77.635 47.719 1 . 00 20 . 04 C ATOM 948 CB VAL 256 15.277 78.894 48.441 1.00 18.61 C
ATOM 949 CGl VAL 256 14.627 78.993 49.828 1.00 20.58 C
ATOM 950 CG2 VAL 256 16.810 78.820 48.590 1.00 21.15 C
ATOM 951 C VAL 256 13.258 77.543 47.881 1.00 19.99 C
ATOM 952 O VAL 256 12.772 76.800 48.720 1.00 21.57 O
ATOM 953 N SER 257 12.529 78.302 47.070 1.00 21.42 N
ATOM 954 CA SER 257 11.066 78.313 47.104 1.00 24.14 C
ATOM 955 CB SER 257 10.537 79.295 46.058 1.00 24.03 C
ATOM 956 OG SER 257 9.118 79.329 46:061 1.00 22.89 O
ATOM 957 C SER 257 10.488 76.921 46.848 1.00 23.61 C
ATOM 958 O SER 257 9.592 76.464 47.563 1.00 24.22 O
ATOM 959 N ALA 258 11.000 76.251 45.823 1.00 22.12 N
ATOM 960 CA ALA 258 10.538 74.908 45.496 1.00 22.29 C
ATOM 961 CB ALA 258 11.162 74.455 44.173 1.00 21.17 C
ATOM 962 C ALA 258 10.876 73.912 46.620 1.00 22.60 C
ATOM 963 O ALA 258 10.039 73.097 47.001 1.00 21.73 O
ATOM 964 N LEU 259 12.095 73.983 47.154 1.00 22.67 N
ATOM 965 CA LEU 259 12.513 73.076 48.223 1.00 23.62 C
ATOM 966 CB LEU 259 14.022 73.200 48.484 1.00 22.63 C
ATOM 967 CG LEU 259 14.923 72.699 47.349 1.00 24.76 C
ATOM 968 CDl LEU 259 16.389 72.956 47.692 1.00 24.60 C
ATOM 969 CD2 LEU 259 14.675 71.218 47.104 1.00 24.58 C
ATOM 970 C LEU 259 11.734 73.297 49.511 1.00 24.10 C
ATOM 971 O LEU 259 11.443 72.341 50.230 1.00 25.40 O
ATOM 972 N ASP 260 11.403 74.552 49.804 1.00 25.47 N
ATOM 973 CA ASP 260 10.618 74.896 50.989 1.00 26.23 C
ATOM 974 CB ASP 260 10.416 76.416 51.040 1.00 27.09 C
ATOM 975 CG ASP 260 9.528 76.869 52.199 1.00 28.89 C
ATOM 976 ODl ASP 260 9.558 76.241 53.272 1.00 32.09 O
ATOM 977 OD2 ASP 260 8.820 77.881 52.041 1.00 30.31 O
ATOM 978 C ASP 260 9.276 74.171 50.841 1.00 26.88 C
ATOM 979 O ASP 260 8.780 73.541 51.779 1.00 27.55 O
ATOM 980 N TYR 261 8.708 74.254 49.643 1.00 26.09 N
ATOM 981 CA TYR 261 7.436 73.598 49.333 1.00 25.74 C
ATOM 982 CB TYR 261 7.038 73.928 47.892 1.00 26.75 C
ATOM 983 CG TYR 261 5.950 73.040 47.320 1.00 28.69 C
ATOM 984 CDl TYR 261 4.611 73.235 47.649 1.00 30.18 C
ATOM 985 CEl TYR 261 3.610 72.437 47.094 1.00 30.73 C
ATOM 986 CD2 TYR 261 6.265 72.020 46.426 1.00 30.01 C
ATOM 987 CE2 TYR 261 5.277 71.221 45.870 1.00 31.79 C
ATOM 988 CZ TYR 261 3.954 71.437 46.202 1.00 31.60 C
ATOM 989 OH TYR 261 2.979 70.669 45.600 1.00 32.34 O
ATOM 990 C TYR 261 7.514 72.079 49.515 1.00 25.59 C
ATOM 991 O TYR 261 6.692 71.482 50.215 1.00 26.08 O
ATOM 992 N LEU 262 8.499 71.452 48.883 1.00 26.75 N
ATOM 993 CA LEU 262 8.674 70.006 48.982 1.00 27.51 C
ATOM 994 CB LEU 262 9.849 69.545 48.116 1.00 25.36 C
ATOM 995 CG LEU 262 9.624 69.566 46.601 1.00 27.14 C
ATOM 996 CDl LEU 262 10.945 69.369 45.900 1.00 26.59 C
ATOM 997 CD2 LEU 262 8.625 68.475 46.193 1.00 25.31 C
ATOM 998 C LEU 262 8.888 69.530 50.417 1.00 27.91 C
ATOM 999 O LEU 262 8.321 68.521 50.833 1.00 26.16 O
ATOM 1000 N HIS 263 9.721 70.243 51.166 1.00 27.88 N
ATOM 1001 CA HIS 2G3 9.976 69.874 52.554 1.00 27.52 C
ATOM 1002 CB HIS 263 11.111 70.725 53.129 1.00 24.92 C
ATOM 1003 CG HIS 263 12.446 70.449 52.509 1.00 23.23 C
ATOM 1004 CD2 HIS 263 12.825 69.555 51.565 1.00 21.65 C
ATOM 1005 NDl HIS 263 13.588 71.119 52.881 1.00 22.77 N
ATOM 1006 CEl HIS 263 14.617 70.650 52.194 1.00 21.35 C
ATOM 1007 NE2 HIS 263 14.181 69.700 51.390 1.00 22.70 N
ATOM 1008 C HIS 263 8.710 70.047 53.402 1.00 29.21 C
ATOM 1009 O HIS 263 8.471 69.283 54.340 1.00 30.74 O
ATOM 1010 N SER 264 7.898 71.043 53.071 1.00 31.63 N
ATOM 1011 CA SER 264 6.666 71.275 53.815 1.00 33.38 C
ATOM 1012 CB SER 264 5.966 72.548 53.328 1.00 34.22 C
ATOM 1013 OG SER 264 5.390 72.363 52.043 1.00 36.89 O
ATOM 1014 C SER 264 5.751 70.072 53.616 1.00 34.73 C
ATOM 1015 O SER 264 4.805 69.859 54.378 1.00 35.85 O
ATOM 1016 K GLY 265 6.051 69.285 52.588 1.00 35.18 N
ATOM 1017 CA GLY 265 5.264 68.105 52.294 1.00 35.32 C
ATOM 1018 C GLY 265 5.981 66.835 52.699 1.00 35.76 C
ATOM 1019 O GLY 265 5.631 65.742 52.249 1.00 36.84 O
ATOM 1020 N LYS 266 7.000 66.980 53.539 1.00 35.11 N ATOM 1021 CA LYS 266 7.760 65.839 54.025 1.00 36.21 C
ATOM 1022 CB LYS 266 6.808 64.877 54.750 1.00 38.32 C
ATOM 1023 CG LYS 266 6.119 65.518 55.951 1.00 39.48 C
ATOM 1024 CD LYS 266 5.011 64.638 56.528 1.00 44.50 C
ATOM 102S CE LYS 266 3.756 64.682 55.663 1.00 45.32 C
ATOM 1026 NZ LYS 266 3.207 66.071 55.583 1.00 46.50 N
ATOM 1027 C LYS 266 8.506 65.116 52.912 1.00 36.89 C
ATOM 1028 O LYS 266 8.825 63.933 53.027 1.00 37.09 O
ATOM 1029 N ILE 267 8.794 65.836 51.833 1.00 35.78 N
ATOM 1030 CA ILE 267 9.502 65.254 50.702 1.00 34.40 C
ATOM 1031 CB ILE 267 8.782 65.574 49.386 1.00 36.19 C
ATOM 1032 CG2 ILE 267 9.643 65.139 48.202 1.00 37.48 C
ATOM 1033 CGl ILE 267 7.425 64.874 49.353 1.00 38.01 C
ATOM 1034 CDl ILE 267 6.554 65.280 48.184 1.00 40.48~ C
ATOM 1035 C ILE 267 10.938 65.762 50.586 1.00 33.01 C
ATOM 1036 O ILE 267 11.191 66.958 50.695 1.00 31.99 O
ATOM 1037 N VAL 268 11.872 64.842 50.379 1.00 31.63 N
ATOM 1038 CA VAL 268 13.279 65.186 50.202 1.00 32.21 C
ATOM 1039 CB VAL 268 14.202 64.238 51.009 1.00 32.65 C
ATOM 1040 CGl VAL 268 15.653 64.653 50.838 1.00 31.58 C
ATOM 1041 CG2 VAL 268 13.816 64.252 52.479 1.00 31.89 C
ATOM 1042 C VAL 268 13.516 64.973 48.704 1.00 32.06 C
ATOM 1043 O VAL 268 13.209 63.897 48.184 1.00 32.22 O
ATOM 1044 N TYR 269 14.044 65.982 48.008 1.00 30.86 N
ATOM 1045 CA TYR 269 14.261 65.861 46.566 1.00 30.69 C
ATOM 1046 CB TYR 269 14.462 67.232 45.916 1.00 29.25 C
ATOM 1047 CG TYR 269 14.216 ' 67.194 44.421 1.00 31.46 C
ATOM 1048 CDl TYR 269 12.954 66.910 43.922 1.00 30.81 C
ATOM 1049 CEl TYR 269 12.726 66.802 42.560 1.00 32.93 C
ATOM 1050 CD2 TYR 269 15.252 67.376 43.510 1.00 29.77 C
ATOM 1051 CE2 TYR 269 15.031 67.266 42.143 1.00 31.29 C
ATOM 1052 CZ TYR 269 13.763 66.979 41.677 1.00 32.08 C
ATOM 1053 OH TYR 269 13.518 66.860 40.323 1.00 34.06 O
ATOM 1054 C TYR 269 15.424 64.958 46.179 1.00 30.21 C
ATOM 1055 O TYR 269 15.309 64.148 45.257 1.00 29.77 O
ATOM 1056 N ARG 270 16.549 65.115 46.866 1.00 29.98 N
ATOM 1057 CA ARG 270 17.729 64.297 46.606 1.00 31.87 C
ATOM 1058 CB ARG 270 17.368 62.813 46.775 1.00 34.00 C
ATOM 1059 CG ARG 270 16.976 62.445 48.201 1.00 38.07 C
ATOM 1060 CD ARG 270 16.307 61.075 48.301 1.00 41.40 C
ATOM 1061 NE ARG 270 17.171 59.981 47.873 1.00 45.73 N
ATOM 1062 CZ ARG 270 16.901 58.694 48.084 1.00 46.92 C
ATOM 1063 NHl ARG 270 15.794 58.339 48.722 1.00 47.57 N
ATOM 1064 NH2 ARG 270 17.734 57.760 47.650 1.00 48.57 - N
ATOM 1065 C ARG 270 18.423 64.494 45.255 1.00 30.37 C
ATOM 1066 O ARG 270 19.646 64.356 45.163 1.00 31.17 O
ATOM 1067 N ASP 271 17.665 64.830 44.217 1.00 29.71 N
ATOM 1068 CA ASP 271 18.255 64.978 42.887 1.00 30.37 C
ATOM 1069 CB ASP 271 17.330 64.352 41.843 1.00 31.48 C
ATOM 1070 CG ASP 271 17.012 62.898 42.145 1.00 35.51 C
ATOM 1071 ODl ASP 271 17.869 62.214 42.744 1.00 37.58 O
ATOM 1072 OD2 ASP 271 15.911 62.437 41.776 1.00 38.76 O
ATOM 1073 C ASP 271 18.657 66.381 42.423 1.00 29.22 C
ATOM 1074 O ASP 271 18.893 66.593 41.234 1.00 27.89 O
ATOM 1075 N LEU 272 18.750 67.333 43.344 1.00 29.38 N
ATOM 1076 CA LEU 272 19.142 68.683 42.960 1.00 30.32 C
ATOM 1077 CB LEU 272 19.013 69.646 44.141 1.00 30.55 C
ATOM 1078 CG LEU 272 19.496 71.067 43.841 1.00 27.99 C
ATOM 1079 CDl LEU 272 18.701 71.608 42.672 1.00 28.06 C
ATOM 1080 CD2 LEU 272 19.336 71.964 45.067 1.00 27.21 C
ATOM 1081 C LEU 272 20.582 68.698 42.461 1.00 31.56 C
ATOM 1082 O LEU 272 21.514 68.409 43.211 1.00 34.11 O
ATOM 1083 N LYS 273 20.752 69.037 41.188 1.00 30.70 N
ATOM 1084 CA LYS 273 22.070 69.107 40.566 1.00 30.77 C
ATOM 1085 CB LYS 273 22.527 67.720 40.094 1.00 30.44 C
ATOM 1086 CG LYS 273 21.641 67.121 39.021 1.00 33.13 C
ATOM 1087 CD LYS 273 22.232 65.841 38.428 1.00 37.49 C
ATOM 1088 CE LYS 273 22.257 64.710 39.428 1.00 38.05 C
ATOM 1089 NZ LYS 273 23.128 65.007 40.594 1.00 42.65 N
ATOM 1090 C LYS 273 21.938 70.037 39.372 1.00 28.69 C
ATOM 1091 O LYS 273 20.838 70.244 38.866 1.00 29.43 O
ATOM 1092 N LEU 274 23.056 70.590 38.918 1.00 29.43 N
ATOM 1093 CA LEU 274 23.051 71.526 37.797 1.00 30.20 C ATOM 1094 CB LEU 274 24.483 71.969 37.485 30.95 C
ATOM 109S CG LEU 274 24.672 73.068 36.439 32.04 C
ATOM 1096 CDl LEU 274 23.991 74.345 36.890 30.09 C
ATOM, 1097 CD2 LEU 274 26.167 73.300 36.231 33.71 C
ATOM 1098 C LEU 274 22.412 70.947 36.546 29.99 C
ATOM 1099 O LEU 274 21.691 71.640 35.826 29.29 O
ATOM 1100 N GLU 275 22.679 69.671 36.298 31.17 N
ATOM 1101 CA GLU 275 22.147 68.977 35.136 32.84 C
ATOM 1102 CB GLU 275 22.793 67.591 35.011 36.20 C
ATOM 1103 CG GLU 275 24.308 67.620 34.817 42.22 C
ATOM 1104 CD GLU 275 25.073 67.969 36.087 45.19 C
ATOM 1105 OEl GLU 275 26.312 68.088 36.011 49.87 O
ATOM 1106 OE2 GLU 275 24.450 68.116 37.161 45.52 O
ATOM 1107 C GLU 275 20.627 68.835 35.182 32.38 C
ATOM 1108 O GLU 275 20.003 68.547 34.164 32.14 O
ATOM 1109 N ASN 276 20.035 69.036 36.356 30.60 N
ATOM 1110 CA ASN 276 18.583 68.933 36.501 30.02 C
ATOM 1111 CB ASN 276 18.219 68.051 37.695 28.98 C
ATOM 1112 CG ASN 276 18.332 66.576 37.369 1.00 32.41 C
ATOM 1113 ODl ASN 276 18.041 66.164 36.246 32.54 O
ATOM 1114 ND2 ASN 276 18.740 65.770 38.349 31.96 N
ATOM 1115 C ASN 276 17.896 70.283 36.632 28.94 C
ATOM 1116 O ASN 276 16.770 70.384 37.134 29.81 O
ATOM 1117 N LEU 277 18.581 71.319 36.168 27.44 N
ATOM 1118 CA LEU 211 18.048 72.666 36.207 27.08 C
ATOM 1119 CB LEU 211 18.971 73.573 37.019 25.95 C
ATOM 1120 CG LEU 277 19.124 73.219 38.493 25.39 C
ATOM 1121 CDl LEU 277 20.147 74.139 39.132 23.90 C
ATOM 1122 CD2 LEU 277 17.772 73.354 39.170 26.19 C
ATOM 1123 C LEU 277 17.930 73.226 34.798 27.67 C
ATOM 1124 O LEU 277 18.881 73.185 34.029 28.45 O
ATOM 1125 N MET 278 16.757 73.739 34.463 28.10 N
ATOM 1126 CA MET 278 16.549 74.343 33.161 30.03 C
ATOM 1127 CB MET 278 15.711 73.438 32.263 31.73 C
ATOM 1128 CG MET 278 16.377 72.127 31.904 36.57 C
ATOM 1129 SD MET 278 15.509 71.366 30.537 43.97 S
ATOM 1130 CE MET 278 13.893 71.166 31.270 39.39 C
ATOM 1131 C MET 278 15.832 75.671 33.321 29.16 C
ATOM 1132 O MET 278 15.331 75.994 34.400 29.08 O
ATOM 1133 N LEU 279 15.793 76.443 32.241 27.72 N
ATOM 1134 CA LEU 279 15.105 77.721 32.246 28.45 C
ATOM 1135 CB LEU 279 16.009 78.830 31.701 27.00 C
ATOM 1136 CG LEU 279 17.329 79.116 32.424 27.16 C
ATOM 1137 CDl LEU 279 18.032 80.281 31.730 28.30 C
ATOM 1138 CD2 LEU 279 17.048 79.460 33.895 26.35 C
ATOM 1139 C LEU 279 13.888 77.608 31.346 28.07 C
ATOM 1140 O LEU 279 13.941 76.927 30.318 29.84 O
ATOM 1141 N ASP 280 12.787 78.248 31.724 29.16 N
ATOM 1142 CA ASP 280 11.625 78.226 30.858 29.88 C
ATOM 1143 CB ASP 280 10.292 78.359 31.626 29.24 C
ATOM 1144 CG ASP 280 10.179 79.639 32.442 29.20 C
ATOM 1145 ODl ASP 280 10.818 80.660 32.102 29.18 O
ATOM 1146 OD2 ASP 280 9.404 79.622 33.427 28.79 O
ATOM 1147 C ASP 280 11.818 79.378 29.885 31.09 C
ATOM 1148 O ASP 280 12.832 80.079 29.941 29.86 O
ATOM 1149 N LYS 281 10.866 79.562 28.979 31.88 N
ATOM 1150 CA LYS 281 10.966 80.617 27.980 32.31 C
ATOM 1151 CB LYS 281 9.722 80.602 27.087 34.36 C
ATOM 1152 CG LYS 281 8.416 80.636 27.854 37.28 C
ATOM 1153 CD LYS 281 7.227 80.470 26.929 41.32 C
ATOM 1154 CE LYS 281 5.950 80.293 27.726 42.15 C
ATOM 1155 NZ LYS 281 5.744 81.427 28.669 46.71 N
ATOM 1156 C LYS 281 11.177 82.016 28.546 30.91 C
ATOM 1157 O LYS 281 11.692 82.888 27.856 32.60 O
ATOM 1158 N ASP 282 10.795 82.237 29.797 30.53 N
ATOM 1159 CA ASP 282 10.948 83.556 30.391 30.18 C
ATOM 1160 CB ASP 282 9.723 83.884 31.242 32.63 C
ATOM 1161 CG ASP 282 8.439 83.899 30.429 36.34 C
ATOM 1162 ODl ASP 282 8.414 84.572 29.375 39.00 O
ATOM 1163 OD2 ASP 282 7.458 83.242 30.842 37.51 O
ATOM 1164 C ASP 282 12.225 83.736 31.215 28.41 C
ATOM 1165 O ASP 282 12.511 84.832 31.686 28.86 O
ATOM 1166 N GLY 283 12.991 82.664 31.378 1.00 27.97 N ATOM 1167 CA GLY 283 14.222 82.760 32.142 00 26.21 C
ATOM 1168 C GLY 283 14.054 82.368 33.604 00 25.42 C
ATOM 1169 O GLY 283 14.976 82.544 34.403 00 22.87 O
ATOM 1170 N HIS 284 12.875 81.872 33.962 00 24.48 N
ATOM 1171 CA HIS 284 12.626 81.413 35.333 00 26.02 C
ATOM 1172 CB HIS 284 11.133 81.474 35.684 00 25.35 C
ATOM 1173 CG HIS 284 10.636 82.850 36.013 1.00 24.42 C
ATOM 1174 CD2 HIS 284 9.877 83.717 35.302 1.00 24.85 C
ATOM 1175 NDl HIS 284 10.927 83.483 37.202 1.00 24.33 N
ATOM 1176 CEl HIS 284 10.370 84.682 37.209 1.00 24.39 C
ATOM 1177 NE2 HIS 284 9.729 84.849 36.067 24.81 N
ATOM 1178 C HIS 284 13.102 79.959 35.421 26.05 C
ATOM 1179 O HIS 284 13.157 79.241 34.409 27.68 O
ATOM 1180 N ILE 285 13.438 79.542 36.635 26.20 N
ATOM 1181 CA ILE 285 13.928 78.196 36.939 27.17 C
ATOM 1182 CB ILE 285 14.473 78.132 38.402 27.17 C
ATOM 1183 CG2 ILE 285 14.416 76.714 38.913 30.92 C
ATOM 1184 CGl ILE 285 15.897 78.685 38.484 28.41 C
ATOM 1185 CDl ILE 285 16.928 77.787 37.855 30.56 C
ATOM 1186 C ILE 285 12.865 77.103 36.831 27.66 C
ATOM 1187 O ILE 285 11.682 77.336 37.093 25.26 O
ATOM 1188 N LYS 286 13.311 75.909 36.451 26.65 N
ATOM 1189 CA LYS 286 12.458 74.739 36.373 29.31 C
ATOM 1190 CB LYS 286 11.910 74.532 34.963 30.81 C
ATOM 1191 CG LYS 286 10.742 73.565 34.926 34.09 C
ATOM 1192 CD LYS 286 9.513 74.135 35.633 34.51 C
ATOM 1193 CE LYS 286 8.964 75.352 34.906 34.67 C
ATOM 1194 NZ LYS 286 7.608 75.729 35.385 36.04 N
ATOM 1195 C LYS 286 13.320 73.540 36.764 29.44 C
ATOM 1196 O LYS 286 14.285 73.199 36.082 1.00 29.25 O
ATOM 1197 N ILE 287 12.984 72.925 37.886 29.55 N
ATOM 1198 CA ILE 287 13.717 71.762 38.354 30.78 C
ATOM 1199 CB ILE 287 13.571 71.601 39.882 29.36 C
ATOM 1200 CG2 ILE 287 14.240 70.314 40.342 29.62 C
ATOM 1201- CGl ILE 287 14.204 72.802 40.588 28.98 C
ATOM 1202 CDl ILE 287 13.974 72.821 42.092 29.43 C
ATOM 1203 C ILE 287 13.142 70.537 37.654 33.18 C
ATOM 1204 O ILE 287 11.929 70.325 37.669 32.13 O
ATOM 1205 N THR 288 14.009 69.753 37.017 36.06 N
ATOM 1206 CA THR 288 13.580 68.542 36.318 40.93 C
ATOM 1207 CB THR 288 13.984 68.535 34.821 41.42 C
ATOM 1208 OGl THR 288 13.973 69.866 34.297 44.32 O
ATOM 1209 CG2 THR 288 13.006 67.681 34.025 42.37 C
ATOM 1210 C THR 288 14.265 67.335 36.941 43.10 C
ATOM 1211 O THR 288 14.847 67.419 38.017 1.00 45.12 O
ATOM 1212 N ASP 289 14.202 66.211 36.241 46.32 N
ATOM 1213 CA ASP 289 14.833 64.984 36.698 48.96 C
ATOM 1214 CB ASP 289 14.006 64.338 37.815 49.00 C
ATOM 1215 CG ASP 289 14.861 63.548 38.788 48.13 C
ATOM 1216 ODl ASP 289 14.324 63.094 39.818 46.66 O
ATOM 1217 OD2 ASP 289 16.072 63.383 38.523 47.76 O
ATOM 1218 C ASP 289 14.940 64.044 35.504 51.31 C
ATOM 1219 O ASP 289 14.398 64.331 34.434 49.56 O
ATOM 1220 N PHE 290 15.641 62.930 35.696 54.57 N
ATOM 1221 CA PHE 290 15.843 61.942 34.641 58.37 C
ATOM 1222 CB PHE 290 14.546 61.750 33.839 58.01 C
ATOM 1223 CG PHE 290 13.345 61.444 34.698 57.88 C
ATOM 1224 CDl PHE 290 12.069 61.777 34.276 58.24 C
ATOM 1225 CD2 PHE 290 13.499 60.844 35.938 58.18 C
ATOM 1226 CEl PHE 290 10.968 61.522 35.078 58.77 C
ATOM 1227 CE2 PHE 290 12.403 60.586 36.743 58.32 C
ATOM 1228 CZ PHE 290 11.136 60.925 36.315 58.61 C
ATOM 1229 C PHE 290 16.978 62.426 33.737 60.61 C
ATOM 1230 O PHE 290 18.093 62.664 34.210 61.35 O
ATOM 1231 N GLY 291 16.697 62.578 32.447 63.00 N
ATOM 1232 CA GLY 291 17.718 63.036 31.521 66.44 C
ATOM 1233 C GLY 291 18.674 61.929 31.113 68.41 C
ATOM 1234 O GLY 291 19.013 61.065 31.921 68.59 O
ATOM 1235 N LEU 292 19.118 61.958 29.859 70.64 N
ATOM 1236 CA LEU 292 20.028 60.939 29.351 73.16 C
ATOM 1237 CB LEU 292 19.736 60.657 27.873 12.16 C
ATOM 1238 CG LEU 292 18.284 60.363 27.476 72.91 C
ATOM 1239 CDl LEU 292 17.641 59.469 28.522 1.00 72.91 C ATOM 1240 CD2 LEU 292 17.504 61.658 27.354 00 72.37 C
ATOM 1241 C LEU 292 21.501 61.322 29.519 00 75.22 C
ATOM 1242 O LEU 292 22.373 60.451 29.599 00 75.77 O
ATOM 1243 N CYS 293 21.773 62.624 29.579 00 76.97 N
ATOM 1244 CA CYS 293 23.139 63.122 29.729 00 78.48 C
ATOM 1245 CB CYS 293 23.141 64.654 29.774 00 78.69 C
ATOM 1246 SG CYS 293 22.281 65.363 31.205 1.00 80.30 S
ATOM 1247 C CYS 293 23.821 62.578 30.984 1.00 79.40 C
ATOM 1248 O CYS 293 23.316 61.658 31.634 79.35 O
ATOM 1249 N LYS 294 24.972 63.159 31.317 80.32 N
ATOM 1250 CA LYS 294 25.740 62.747 32.487 80.91 C
ATOM 1251 CB LYS 294 24.878 62.871 33.753 80.81 C
ATOM 1252 CG LYS 294 25.578 62.523 35.073 80.40 C
ATOM 1253 CD LYS 294 25.639 61.017 35.326 79.78 C
ATOM 1254 CE LYS 294 26.168 60.701 36.719 78.96 C
ATOM 1255 NZ LYS 294 26.226 59.230 36.970 77.68 N
ATOM 1256 C LYS 294 26.252 61.317 32.336 81.44 C
ATOM 1257 O LYS 294 25.509 60.354 32.526 81.58 O
ATOM 1258 N GLU 295 27.527 61.193 31.977 1.00 82.05 N
ATOM 1259 CA GLU 295 28.165 59.889 31.816 82.36 C
ATOM 1260 CB GLU 295 27.783 59.241 30.481 82.03 C
ATOM 1261 CG GLU 295 28.187 57.770 30.402 82.01 C
ATOM 1262 CD GLU 295 28.260 57.241 28.982 81.97 C
ATOM 1263 OEl GLU 295 28.501 56.026 28.817 1.00 81.48 O
ATOM 1264 OE2 GLU 295 28.084 58.036 28.033 81.94 O
ATOM 1265 C GLU 295 29.682 60.047 31.878 82.62 C
ATOM 1266 O GLU 295 30.233 60.397 32.921 82.77 O
ATOM 1267 N GLY 296 30.348 59.795 30.754 1.00 82.83 N
ATOM 1268 CA GLY 296 31.796 59.910 30.708 83.27 C
ATOM 1269 C GLY 296 32.478 58.979 31.695 83.52 C
ATOM 1270 O GLY 296 32.973 59.418 32.736 83.64 O
ATOM 1271 N ILE 297 32.511 57.690 31.367 83.67 N
ATOM 1272 CA ILE 297 33.125 56.S93 32.237 83.72 C
ATOM 1273 CB ILE 297 32.196 55.448 32.360 83.21 C
ATOM 1274 CG2 ILE 297 31.919 54.858 30.985 1.00 82.47 C
ATOM 1275 CGl ILE 297 32.815 54.413 33.297 00 83.03 C
ATOM 1276 CDl ILE 297 31.941 53.193 33.507 00 82.85 C
ATOM 1277 C ILE 297 34.519 56.292 31.732 00 84.09 C
ATOM 1278 O ILE 297 34.707 55.231 31.132 00 83.95 O
ATOM 1279 N THR 298 35.495 57.160 31.988 00 84.49 N
ATOM 1280 CA THR 298 36.872 56.936 31.565 00 84.81 C
ATOM 1281 CB THR 298 37.360 58.092 30.687 00 84.92 C
ATOM 1282 OGl THR 298 38.733 57.879 30.331 00 84.99 O
ATOM 1283 CG2 THR 298 37.215 59.423 31.420 00 84.43 C
ATOM 1284 C THR 298 37.833 56.787 32.739 00 85.16 C
ATOM 1285 O THR 298 38.684 57.651 32.977 .00 84.86 O
ATOM '1286 N ASP 299 37.697 55.680 33.460 .00 85.48 N
ATOM 1287 CA ASP 299 38.542 55.403 34.613 00 ■ 85.71 C
ATOM 1288 CB ASP 299 38.564 56.609 35.554 00 85.87 C
ATOM 1289 CG ASP 299 39.374 56.353 36.809 00 86.08 C
ATOM 1290 ODl ASP 299 40.574 56.021 36.687 00 85.72 O
ATOM 1291 OD2 ASP 299 38.809 56.483 37.917 00 86.19 O
ATOM 1292 C ASP 299 38.020 54.180 35.360 00 85.74 C
ATOM 1293 O ASP 299 38.652 53.120 35.354 00 85.73 O
ATOM 1294 N ALA 300 36.863 54.340 36.002 00 85.38 N
ATOM 1295 CA ALA 300 36.232 53.267 36.760 00 85.23 C '
ATOM 1296 CB ALA 300 36.518 53.445 38.250 .00 84.86 C
ATOM 1297 C ALA 300 34.726 53.269 36.513 .00 85.17 C
ATOM 1298 O ALA 300 34.182 54.234 35.975 .00 85.19 O
ATOM 1299 N ALA 301 34.057 52.188 36.905 .00 85.29 N
ATOM 1300 CA ALA 301 32.610 52.081 36.732 .00 85.12 C
ATOM 1301 CB ALA 301 32.176 50.617 36.774 .00 84.89 C
ATOM 1302 C ALA 301 31.906 52.870 37.830 .00 85.16 C
ATOM 1303 O ALA 301 32.489 53.782 38.421 1 00 85.35 O
ATOM 1304 N THR 302 30.657 52.511 38.109 1 00 84.93 N
ATOM 1305 CA THR 302 29.881 53.204 39.130 1 00 84.64 C
ATOM 1306 CB THR 302 28.407 53.347 38.698 1 00 84.66 C
ATOM 1307 OGl THR 302 27.845 52.048 38.475 1 00 84.33 O
ATOM 1308 CG2 THR 302 28.306 54.167 37.416 1 00 84.81 C
ATOM 1309 C THR 302 29.921 52.527 40.498 1 00 84.54 C
ATOM 1310 0 THR 302 30.434 51.416 40.651 1 00 84.64 O
ATOM 1311 N MET 303 29.371 53.221 41.489 1 00 84.13 N
ATOM 1312 CA MET 303 29.311 52.731 42.862 1.00 83.70 C ATOM 1313 CB MET 303 30.245 53.554 43.755 1.00, 84.26 C
ATOM 1314 CG MET 303 29.864 53.573 45.234 1.00 85.05 C
ATOM 1315 SD MET 303 29.930 51.963 46.054 1.00 86.32 S
ATOM 1316 CE MET 303 31.618 51.965 46.671 1.00 85.24 C
ATOM 1317 C MET 303 27.879 52.855 43.365 1.00 82.88 C
ATOM 1318 O MET 303 27.375 53.964 43.550 1.00 82.95 O
ATOM 1319 N LYS 304 27.221 51.720 43.578 1.00 81.66 N
ATOM 1320 CA LYS 304 25.846 51.739 44.055 1.00 80.35 C
ATOM 1321 CB LYS 304 25.071 50.538 43.512 1.00 80.20 C
ATOM 1322 CG LYS 304 24.729 50.635 42.029 1.00 80.20 C
ATOM 1323 CD LYS 304 23.851 51.850 41.710 1.00 78.93 C
ATOM 1324 CE LYS 304 24.670 53.127 41.527 1.00 78.07 C
ATOM 1325 NZ LYS 304 23.818 54.292 41.165 1.00 76.01 N
ATOM 1326 C LYS 304 25.738 51.785 45.570, 1.00 79.75 C
ATOM 1327 O LYS 304 26.709 51.523 46.287 1.00 79.26 O
ATOM 1328 N ASP 305 24.534 52.117 46.029 1.00 79.12 N
ATOM 1329 CA ASP 305 24.188 52.258 47.442 1.00 78.26 C
ATOM 1330 CB ASP 305 25.151 51.484 48.349 1.00 78.93 C
ATOM 1331 CG ASP 305 24.699 51.470 49.800 1.00 79.52 C
ATOM 1332 ODl ASP 305 23.671 50.822 50.098 1.00 79.46 O
ATOM 1333 OD2 ASP 305 25.366 52.114 50.641 1.00 79.65 O
ATOM 1334 C ASP 305 24.281 53.746 47.739 1.00 77.05 C
ATOM 1335 O ASP 305 24.321 54.168 48.895 1.00 76.79 O
ATOM 1336 N PHE 306 24.316 54.531 46.665 1.00 75.83 N
ATOM 1337 CA PHE 306 24.400 55.984 46.748 1.00 74.48 ' C
ATOM 1338 CB PHE 306 25.790 56.450 46.305 1.00 73.06 C
ATOM 1339 CG PHE 306 26.852 56.253 47.349 1.00 72.10 C
ATOM 1340 CDl PHE 306 28.192 56.247 47.004 1.00 71.77 C
ATOM 1341 CD2 PHE 306 26.507 56.093 48.683 1.00 71.74 C
ATOM 1342 CEl PHE 306 29.170 56.085 47.974 1.00 71.47 C
ATOM 1343 CE2 PHE 306 27.479 55.932 49.654 1.00 71.43 C
ATOM 1344 CZ PHE 306 28.810 55.927 49.299 1.00 70.95 C
ATOM 1345 C PHE 306 23.324 56.628 45.876 1.00 73.83 C
ATOM 1346 O PHE 306 22.526 57.439 46.356 1.00 73.88 O
ATOM 1347 N CYS 307 23.308 56.263 44.598 1.00 72.80 N
ATOM 1348 CA CYS 307 22.330 56.795 43.657 1.00 72.20 C
ATOM 1349 CB CYS 307 20.915 56.599 44.215 1.00 72.65 C
ATOM 1350 SG CYS 307 19.580 57.185 43.145 1.00 75.50 S
ATOM 1351 C CYS 307 22.578 58.277 43.366 1.00 70.88 C
ATOM 1352 O CYS 307 22.588 59.109 44.277 1.00 71.01 O
ATOM 1353 N GLY 308 22.779 58.598 42.092 1.00 69.09 N
ATOM 1354 CA GLY 308 23.023 59.976 41.708 1.00 66.54 C
ATOM 1355 C GLY 308 24.489 60.267 41.450 1.00 64.59 C
ATOM 1356 O GLY 308 25.345 59.396 41.627 1.00 64.52 O
ATOM 1357 N THR 309 24.775 61.498 41.034 1.00 62.31 N
ATOM 1358 CA THR 309 26.140 61.929 40.738 1.00 59.90 C
ATOM 1359 CB THR 309 26.141 63.307 40.062 1.00 59.54 C
ATOM 1360 OGl THR 309 25.330 63.258 38.883 1.00 61.25 O
ATOM 1361 CG2 THR 309 27.553 63.710 39.684 1.00 60.15 C
ATOM 1362 C THR 309 26.992 62.008 42.003 1.00 57.60 C
ATOM 1363 O THR 309 26.583 62.591 43.005 1.00 57.43 O
ATOM 1364 N PRO 310 28.200 61.427 41.960 1.00 55.66 N
ATOM 1365 CD PRO 310 28.715 60.670 40.806 1.00 55.55 C
ATOM 1366 CA PRO 310 29.158 61.392 43.072 1.00 53.66 C
ATOM 1367 CB PRO 310 30.351 60.642 42.476 1.00 53.69 C
ATOM 1368 CG PRO 310 29.709 59.739 41.462 1.00 54.83 C
ATOM 1369 C PRO 310 29.563 62.759 43.620 1.00 51.36 C
ATOM 1370 O PRO 310 29.639 62.951 44.834 1.00 50.66 O
ATOM 1371 N GLU 311 29.831 63.699 42.719 1.00 49.49 N
ATOM 1372 CA GLU 311 30.242 65.046 43.099 1.00 46.94 C
ATOM 1373 CB GLU 311 30.578 65.868 41.851 1.00 47.94 C
ATOM 1374 CG GLU 311 31.847 65.440 41.111 1.00 50.00 C
ATOM 1375 CD GLU 311 31.791 64.013 40.589 1.00 50.12 C
ATOM 1376 OEl GLU 311 30.781 63.637 39.958 1.00 49.34 O
ATOM 1377 OE2 GLU 311 32.771 63.269 40.804 1.00 52.92 O
ATOM 1378 C GLU 311 29.187 65.784 43.917 1.00 44.85 C
ATOM 1379 O GLU 311 29.481 66.798 44.546 1.00 43.96 O
ATOM 1380 N TYR 312 27.958 65.280 43.905 1.00 43.51 N
ATOM 1381 CA TYR 312 26.884 65.917 44.654 1.00 42.23 C
ATOM 1382 CB TYR 312 25.640 66.086 43.779 1.00 41.09 C
ATOM 1383 CG TYR 312 25.756 67.171 42.737 1.00 40.95 C
ATOM 1384 CDl TYR 312 26.473 66.961 41.567 1.00 40.33 C
ATOM 1385 CEl TYR 312 26.567 67.942 40.602 1.00 41.20 C T7US2004/026569
ATOM 1386 CD2 TYR 312 25.136 68.404 42.917 00 38.57 C
ATOM 1387 CE2 TYR 312 25.226 69.393 41.955 00 39.25 C
ATOM 1388 CZ TYR 312 25.940 69.154 40.797 00 39.80 C
ATOM 1389 OH TYR 312 26.005 70.108 39.809 00 40.96 O
ATOM 1390 C TYR 312 26.490 65.168 45.919 00 42.43 C
ATOM 1391 O TYR 312 25.516 65.534 46.579 00 43.16 O
ATOM 1392 N LEU 313 27.231 64.120 46.260 00 40.63 N
ATOM 1393 CA LEU 313 26.911 63.351 47.452 00 39.21 C
ATOM 1394 CB LEU 313 27.643 62.007 47.431 00 39.93 C
ATOM 1395 CG LEU 313 27.218 61.037 46.328 00 39.34 C
ATOM 1396 CDl LEU 313 28.069 59.784 46.404 00 39.53 C
ATOM 1397 CD2 LEU 313 25.744 60.693 46.486 00 40.16 C
ATOM 1398 C LEU 313 27.260 64.107 48.730 00 38.08 C
ATOM 1399 O LEU 313 28.376 64.588 48.895 00 36.59 O
ATOM 1400 N ALA 314 26.291 64.199 49.632 00 37.87 N
ATOM 1401 CA ALA 314 26.478 64.886 50.903 00 37.38 C
ATOM 1402 CB ALA 314 25.122 65.199 51.518 00 37.17 C
ATOM 1403 C ALA 314 27.298 64.017 51.852 00 37.34 C
ATOM 1404 O ALA 314 27.331 62.796 51.712 00 38.19 O
ATOM 140S N PRO 315 27.979 64.641 52.829 00 36.11 N
ATOM 1406 CD PRO 315 28.077 66.097 53.024 00 34.87 C
ATOM 1407 CA PRO 315 28.804 63.932 53.811 00 35.55 C
ATOM 1408 CB PRO 315 29.262 65.047 54.743 00 35.88 C
ATOM 1409 CG PRO 315 29.345 66.227 53.828 00 36.04 C
ATOM 1410 C PRO 315 28.051 62.842 54.570 00 36.13 C
ATOM 1411 O PRO 315 28.570 61.737 54.761 00 35.88 O
ATOM 1412 N GLU 316 26.834 63.154 55.011 00 36.07 N
ATOM 1413 CA GLU 316 26.042 62.192 55.767 00 36.65 C
ATOM 1414 CB GLU 316 24.796 62.856 56.371 00 35.11 C
ATOM 1415 CG GLU 316 23.859 63.476 55.354 00 33.82 C
ATOM 1416 CD GLU 316 24.131 64.946 55.131 00 31.12 C
ATOM 1417 OEl GLU 316 25.302 65.360 55.252 00 28.57 O
ATOM 1418 OE2 GLU 316 23.172 65.682 54.819 00 29.01 O
ATOM 1419 C . GLU 316 25.637 61.009 54.905 00 37.74 C
ATOM 1420 O GLU 316 25.441 59.903 55.411 00 38.74 O
ATOM 1421 N VAL 317 25.498 61.236 53.604 00 38.89 N
ATOM 1422 CA VAL 317 25.150 60.149 52.702 00 40.48 C
ATOM 1423 CB VAL 317 24.778 60.661 51.296 00 40.64 C
ATOM 1424 CGl VAL 317 24.837 59.518 50.300 00 41.18 C
ATOM 1425 CG2 VAL 317 23.372 61.259 51.313 00 39.32 C
ATOM 1426 C VAIi 317 26.378 59.256 52.606 00 41.75 C
ATOM 1427 O VAL 317 26.288 58.040 52.776 00 42.15 O
ATOM 1428 N LEU 318 27.528 59.872 52.350 00 43.47 N
ATOM 1429 CA LEU 318 28.791 59.148 52.253 00 46.12 C
ATOM 1430 CB LEU 318 29.949 60.130 52.076 00 44.80 C
ATOM 1431 CG LEU 318 30.573 60.146 50.681 00 44.82 C
ATOM 1432 CDl LEU 318 29.487 60.013 49.633 00 45.28 C
ATOM 1433 CD2 LEU 318 31.367 61.429 50.493 00 44.74 C
ATOM 1434 C LEU 318 29.021 58.315 53.505 00 48.69 C
ATOM 1435 O LEU 318 29.357 57.134 53.424 00 48.95 O
ATOM 1436 N GLU 319 28.846 58.938 54.664 00 51.36 N
ATOM 1437 CA GLU 319 29.020 58.239 55.926 00 55.08 C
ATOM 1438 CB GLU 319 29.059 59.227 57.093 00 55.16 C
ATOM 1439 CG GLU 319 30.385 59.937 57.285 00 56.62 C
ATOM 1440 CD GLU 319 30.314 60.988 58.375 00 57.88 C
ATOM 1441 OEl GLU 319 29.607 62.000 58.176 00 58.97 O
ATOM 1442 OE2 GLU 319 30.954 60.803 59.431 00 58.47 O
ATOM 1443 C GLU 319 27.857 57.283 56.123 00 57.28 C
ATOM 1444 O GLU 319 26.979 57.170 55.270 00 58.14 O
ATOM 1445 N ASP 320 27.857 56.596 57.255 00 59.93 N
ATOM 1446 CA ASP 320 26.792 55.663 57.565 00 63.81 C
ATOM 1447 CB ASP 320 27.038 55.058 58.945 00 65.64 C
ATOM 1448 CG ASP 320 28.518 54.832 59.222 00 67.03 C
ATOM 1449 ODl ASP 320 29.174 54.114 58.434 00 67.51 O
ATOM 1450 OD2 ASP 320 29.025 55.379 60.226 00 67.51 O
ATOM 1451 C ASP 320 25.482 56.452 57.537 00 64.88 C
ATOM 1452 O ASP 320 25.304 57.406 58.294 00 65.39 O
ATOM 1453 N ASN 321 24.579 56.052 56.648 00 66.21 N
ATOM 1454 CA ASN 321 23.291 56.718 56.483 00 67.01 C
ATOM 1455 CB ASN 321 22.303 55.776 55.795 00 68.00 C
ATOM 1456 CG ASN 321 22.418 55.827 54.291 00 68.90 C
ATOM 1457 ODl ASN 321 22.142 56.858 53.677 00 69.95 O
ATOM 1458 ND2 ASN 321 22.837 54.720 53.686 1.00 69.05 N ATOM 1459 C ASN 321 22.648 57.297 57.736 1.00 66.64 C
ATOM 1460 O ASN 321 22.893 56.837 58.851 1.00 67.12 O
ATOM 1461 N ASP 322 21.814 58.310 57.514 65.89 N
ATOM 1462 CA ASP 322 21.089 59.030 58.557 64.35 C
ATOM 1463 CB ASP 322 21.944 59.158 59.824 66.39 C
ATOM 1464 CG ASP 322 21.111 59.345 61.081 67.94 C
ATOM 1465 ODl ASP 322 20.336 60.323 61.152 69.49 O
ATOM 1466 OD2 ASP 322 21.233 58.509 62.002 68.26 O
ATOM 1467 C ASP 322 20.841 60.418 57.963 62.22 C
ATOM 1468 O ASP 322 20.959 61.435 58.650 S2.70 O
ATOM 1469 N TYR 323 20.504 60.447 56.677 58.28 N
ATOM 1470 CA TYR 323 20.270 61.705 55.974 1.00 54.71 C
ATOM 1471 CB TYR 323 21.011 61.691 54.634 55.44 C
ATOM 1472 CG TYR 323 20.350 60.858 53.557 57.61 C
ATOM 1473 CDl TYR 323 19.237 61.332 52.865 59.01 C
ATOM 1474 CEl TYR 323 18.645 60.585 51.859 60.05 C
ATOM 1475 CD2 TYR 323 20.849 59.607 53.215 59.04 C
ATOM 1476 CE2 TYR 323 20.264 58.852 52.209 60.06 C
ATOM 1477 CZ TYR 323 19.164 59.346 51.534 60.93 C
ATOM 1478 OH TYR 323 18.594 58.607 50.519 61.60 O
ATOM 1479 C TYR 323 18.793 62.005 55.736 1.00 50.70 C
ATOM 1480 O TYR 323 17.960 61.099 55.726 51.13 O
ATOM 1481 N GLY 324 18.487 63.285 55.531 46.20 N
ATOM 1482 CA GLY 324 17.120 63.717 55.292 39.07 C
ATOM 1483 C GLY 324 17.086 65.006 54.485 34.87 C
ATOM 1484 O GLY 324 17.948 65.224 53.633 33.17 O
ATOM 1485 N ARG 325 16.119 65.873 54.773 31.08 N
ATOM 1486 CA ARG 325 15.972 67.132 54.042 28.86 C
ATOM 1487 CB ARG 325 14.834 67.969 54.641 27.17 C
ATOM 1488 CG ARG 325 15.056 68.402 56.078 27.56 C
ATOM 1489 CD 1ARG 325 13.818 69.076 56.645 30.54 C
ATOM 1490 NE ARG 325 13.867 69.151 58.105 32.67 N
ATOM 1491 CZ ARG 325 14.625 69.994 58.803 33.57 C
ATOM 1492 NHl ARG 325 15.413 70.871 58.189 29.79 N
ATOM 1493 NH2 ARG 325 14.616 69.937 60.132 33.62 N
ATOM 1494 C ARG 325 17.236 67.987 53.938 28.70 C
ATOM 1495 O ARG 325 17.397 68.733 52.973 27.13 O
ATOM 1496 N ALA 326 18.130 67.890 54.920 27.25 N
ATOM 1497 CA ALA 326 19.364 68.668. 54.878 26.19 C
ATOM 1498 CB ALA 326 20.185 68.431 56.148 25.95 C
ATOM 1499 C ALA 326 20.213 68.364 53.641 25.80 C
ATOM 1500 O ALA 326 20.996 69.209 53.212 24.92 O
ATOM 1501 N VAL 327 20.072 67.172 53.058 27.19 N
ATOM 1502 CA VAL 327 20.864 66.846 51.870 26.52 C
ATOM 1503 CB VAL 327 20.682 65.379 51.383 28.14 C
ATOM 1504 CGl VAL 327 20.983 64.416 52.502 29.32 C
ATOM 1505 CG2 VAL 327 19.289 65.175 50.826 28.38 C
ATOM 1506 C VAL 327 20.498 67.760 50.705 25.62 C
ATOM 1507 O VAL 327 21.299 67.960 49.802 25.50 O
ATOM 1508 N ASP 328 19.286 68.305 50.718 23.83 N
ATOM 1509 CA ASP 328 18.873 69.203 49.650 24.47 C
ATOM 1510 CB ASP 328 17.346 69.415 49.642 22.17 C
ATOM 1511 CG ASP 328 16.582 68.218 49.072 25.14 C
ATOM 1512 ODl ASP 328 17.205 67.383 48.375 25.67 O
ATOM 1513 OD2 ASP 328 15.350 68.132 49.306 24.48 O
ATOM 1514 C ASP 328 19.579 70.551 49.785 22.45 C
ATOM 1515 O ASP 328 19.829 71.226 48.784 23.27 O
ATOM 1516 N TRP 329 19.913 70.939 51.011 22.96 N
ATOM 1517 CA TRP 329 20.592 72.206 51.228 22.27 C
ATOM 1518 CB TRP 329 20.427 72.661 52.686 23.61 C
ATOM 1519 CG TRP 329 18.969 72.872 53.058 24.17 C
ATOM 1520 CD2 TRP 329 17.994 73.633 52.330 24.81 C
ATOM 1521 CE2 TRP 329 16.769 73.516 53.021 24.94 C
ATOM 1522 CE3 TRP 329 18.039 74.405 51.165 24.29 C
ATOM 1523 CDl TRP 329 18.309 72.338 54.132 23.74 C
ATOM 1524 NEl TRP 329 16.988 72.720 54.113 22.12 N
ATOM 1525 CZ2 TRP 329 15.599 74.136 52.584 22.79 C
ATOM 1526 CZ3 TRP 329 16.874 75.023 50.728 26.47 C
ATOM 1527 CH2 TRP 329 15.671 74.886 51.439 26.88 C
ATOM 1528 C TRP 329 22.061 72.048 50.832 23.34 C
ATOM 1529 O TRP 329 22.678 72.987 50.335 22.12 O
ATOM 1530 N TRP 330 22.617 70.857 51.032 24.52 N
ATOM 1531 CA TRP 330 23.995 70.613 50.614 1.00 24.89 C ATOM 1532 CB TRP 330 24.451 69.204 51.036 .00 25.48 C
ATOM 1533 CG TRP 330 25.766 68.782 50.430 .00 25.76 C
ATOM 1534 CD2 TRP 330 27.069 68.930 51.010 ,00 26.16 C
ATOM 1535 CE2 TRP 330 28.005 68.471 50.061 .00 26.43 C
ATOM 1536 CE3 TRP 330 27.537 69.413 52.240 .00 26.75. C
ATOM 1537 CDl TRP 330 25.961 68.243 49.190 .00 25.80 C
ATOM 1538 NEl TRP 330 27.304 68.056 48.961 ,00 26.97 N
ATOM 1539 CZ2 TRP 330 29.385 68.479 50.302 ,00 25.76 C
ATOM 1540 C23 TRP 330 28.905 69.420 52.475 1.00 26.27 C
ATOM 1541 CH2 TRP 330 29.812 68.957 51.507 ,00 25.50 C
ATOM 1542 C TRP 330 23.978 70.752 49.082 .00 25.12 C
ATOM 1543 O TRP 330 24.827 71.426 48.497 .00 24.55 O
ATOM 1544 N GLY 331 22.985 70.132 48.446 .00 23.56 N
ATOM 1545 CA GLY 331 22.845 70.215 47.002 .00 22.88 C
ATOM 1546 C GLY 331 22.732 71.646 46.498 1.00 22.68 C
ATOM 1547 O GLY 331 23.273 71.977 45.440 23.06 O
ATOM 1548 N LEU 332 22.022 72.497 47.241 22.60 N
ATOM 1549 CA LEU 332 21.875 73.895 46.862 21.96 C
ATOM 1550 CB LEU 332 20.896 74.624 47.789 21.73 C
ATOM 1551 CG LEU 332 20.671 76.113 47.493 22.39 C
ATOM 1552 CDl LEU 332 19.997 76.280 46.130 23.10 C
ATOM 1553 CD2 LEU 332 19.800 76.728 48.595 21.27 C
ATOM 1554 C LEU 332 23.240 74.570 46.951 21.80 C
ATOM 1555 O LEU 332 23.597 75.378 46.098 22.89 O
ATOM 1556 N GLY 333 23.992 74.240 47.994- 20.35 N
ATOM 1557 CA GLY 333 25.310 74.824 48.158 21.45 C
ATOM 1558 C GLY 333 26.201 74.492 46.978 23.04 C
ATOM 1559 O GLY 333 26.890 75.363 46.441 24.90 O
ATOM 1560 N VAL 334 26.199 73.227 46.570 23.13 N
ATOM 1561 CA VAL 334 27.014 72.806 45.439 24.13 C
ATOM 1562 CB VAL 334 26.889 71.281 45.183 25.32 C
ATOM 1563 CGl VAL 334 27.693 70.899 43.943 26.73 C
ATOM 1564 CG2 VAL 334 27.394 70.494 46.402 25.84 C
ATOM 1565 C VAL 334 26.632 73.554 44.156 24.73 C
ATOM 1566 O VAL 334 27.507 74.075 43.462
Figure imgf000083_0001
22.24 O
ATOM 1567 N VAL 335 25.336 73.614 43.834 23.59 N
ATOM 1568 CA VAL 335 24.917 74.308 42.620 22.22 C
ATOM 1569 CB VAL 335 23.412 74.099 42.303 23.58 C
ATOM 1570 CGl VAL 335 23.147 72.640 42.000' 27.70 C
ATOM 1571 CG2 VAL 335 22.562 74.571 43.450 29.56 C
ATOM 1572 C VAL 335 25.198 75.805 42.616 1.00 23.02 C
ATOM 1573 O VAL 335 25.640 76.342 41.597 22.47 O
ATOM 1574 N MET 336 24.942 76.483 43.735 20.56 N
ATOM 1575 CA MET 336 25.197 77.917 43.808 22.86 C
ATOM 1576 CB MET 336 24.557 78.531 45.060 21.56 C
ATOM 1577 CG MET 336 23.016 78.588 44.986 22.59 C
ATOM 1578 SD MET 336 22.222 79.457 46.363 22.79 S
ATOM 1579 CE MET 336 22.472 81.139 45.914 20.50 C
ATOM 1580 C MET 336 26.703 78.190 43.779 23.76 C
ATOM 1581 O MET 336 27.134 79.203 43.227 23.74 O
ATOM 1582 N TYR 337 27.494 77.287 44.358 23.51 N
ATOM 1583 CA TYR 337 28.956 77.430 44.347 23.96 C
ATOM 1584 CB TYR 337 29.616 76.302 45.162 24.99 C
ATOM 1585 CG TYR 337 31.138 76.388 45.208 24.12 C
ATOM 1586 CDl TYR 337 31.912 76.021 44.110 25.99 C
ATOM 1587 CEl TYR 337 33.298 76.138 44.137 26.04 C
ATOM 1588 CD2 TYR 337 31.793 76.874 46.334 24.95 C
ATOM 1589 CE2 TYR 337 33.180 77.000 46.366 25.43 C
ATOM 1590 CZ TYR 337 33.923 76.629 45.263 26.05 C
ATOM 1591 OH TYR 337 35.298 76.759 45.286 30.00 O
ATOM 1592 C TYR 337 29.413 77.359 42.888 24.72 C
ATOM 1593 O TYR 337 30.183 78.194 42.421 25.24 O
ATOM 1594. N GLU 338 28.919 76.353 42.168 26.75 N
ATOM 1595' CA GLU 338 29.241 76.174 40.752 27.22 C
ATOM 1596 CB GLU 338 28.427 75.023 40.164 29.17 C
ATOM 1597 CG GLU 338 28.903 73.635 40.517 33.41 C
ATOM 1598 CD GLU 338 28.083 72.570 39.818 35.73 C
ATOM 1599 OEl GLU 338 26.971 72.269 40.299 37.65 O
ATOM 1600 OE2 GLU 338 28.540 72.046 38.777 35.10 O
ATOM 1601 C GLU 338 28.925 77.433 39.951 26.55 C
ATOM 1602 O GLU 338 29.739 77.908 39.156 26.17 O
ATOM 1603 N MET 339 27.728 77.968 40.161 25.38 N
ATOM 1604 CA MET 339 27.293 79.159 39.444 1.00 25.08 C ATOM 1605 CB MET 339 25.839 79.491 39.805 00 23.16 C
ATOM 1606 CG MET 339 24.820 78.467 39.296 00 24.98 C
ATOM 16O7 SD MET 339 23.126 78.930 39.754 00 27.01 S
ATOM 1608 CE MET 339 22.197 77.636 38.931 00 28.64 C
ATOM 1609 C MET 339 28.173 80.385 39.688 00 25.26 C
ATOM 1610 O MET 339 28.555 81.064 38.738 00 25.35 O
ATOM 1611 N MET 340 28.500 80.653 40.950 00 25.56 N
ATOM 1612 CA MET 340 29.317 81.818 41.314 00 27.77 C
ATOM 1613 CB MET 340 28.989 82.269 42.745 00 27.79 C
ATOM 1614 CG MET 340 27.678 83.034 42.884 00 30.21 C
ATOM 1615 SD MET 340 27.422 83.681 44.551 00 31.79 S
ATOM 1616 CE MET 340 26.567 82.314 45.304 00 32.39 C
ATOM 1617 C MET 340 30.832 81.664 41.203 00 28.72 C
ATOM 1618 O MET 340 31.550 82.664 41.099 00 29.52 O
ATOM 1619 N CYS 341 31.328 80.432 41.229 00 29.52 N
ATOM 1620 CA CYS 341 32.771 80.213 41.165 00 32.01 C
ATOM 1621 CB CYS 341 33.232 79.362 42.354 00 30.37 C
ATOM 1622 SG CYS 341 32.760 79.991 43.971 00 32.48 S
ATOM 1623 C CYS 341 33.270 79.575 39.871 00 32.92 C
ATOM 1624 O CYS 341 34.476 79.551 39.615 00 33.73 O
ATOM 1625 N GLY 342 32.357 79.033 39.074 00 32.83 N
ATOM 1626 CA GLY 342 32.749 78.431 37.809 1.00 35.10 C
ATOM 1627 C GLY 342 33.310 77.018 37.825 1.00 36.36 C
ATOM 1628 O GLY 342 33.914 76.584 36.844 1.00 36.48 O
ATOM 1629 N ARG 343 33.119 76.300 38.926 1.00 36.42 N
ATOM 1630 CA ARG 343 33.596 74.925 39.051 1.00 37.03 C
ATOM 1631 CB ARG 343 35.129 74.886 39.148 1.00 38.92 C
ATOM 1632 CG ARG 343 35.707 75.750 40.254 00 42.26 C
ATOM 1633 CD ARG 343 37.233 75.761 40.234 00 46.92 C
ATOM 1634 NE ARG 343 37.759 76.997 40.811 00 50.77 N
ATOM 1635 CZ ARG 343 37.553 77.389 42.065 00 53.57 C
ATOM 1636 NHl ARG 343 36.836 76.632 42.885 00 55.21 N
ATOM 1637 NH2 ARG 343 38.036 78.552 42.494 00 53.39 N
ATOM 1638 C ARG 343 32.990 74.310 40.303 00 35.82 C
ATOM 1639 O ARG 343 32.457 75.024 41.152 00 34.40 O
ATOM 1640 N LEU 344 33.071 72.987 40.409 00 36.03 N
ATOM 1641 CA LEU 344 32.545 72.282 41.566 00 36.27 C
ATOM 1642 CB LEU 344 32.525 70.776 41.309 00 36.09 C
ATOM 1643 CG LEU 344 31.457 70.262 40.349 00 36.57 C
ATOM 1644 CDl LEU 344 31.787 68.837 39.918 00 36.49 C
ATOM 1645 CD2 LEU 344 30.100 70.335 41.029 00 35.25 C
ATOM 1646 C LEU 344 33.400 72.575 42.791 00 36.68 C
ATOM 1647 O LEU 344 34.584 72.893 42.677 00 36.52 O
ATOM 1648 N PRO 345 32.799 72.497 43.985 00 37.44 N
ATOM 1649 CD PRO 345 31.367 72.286 44.264 00 36.50 C
ATOM 1650 CA PRO 345 33.546 72.758 45.218 00 37.66 C
ATOM 1651 CB PRO - 345 32.443 72.938 46.253 00 37.48 C
ATOM 1652 CG PRO 345 31.365 72.017 45.750 00 37.44 C
ATOM 1653 C PRO 345 34.486 71.602 45.566 00 37.67 C
ATOM 1654 O PRO 345 35.496 71.795 46.237 00 36.92 O
ATOM 1655 N PHE 346 34.143 70.406 45.100 00 38.52 N
ATOM 1656 CA PHE 346 34.942 69.213 45.360 00 41.08 C
ATOM 1657 CB PHE 346 34.275 68.344 46.428 00 39.66 C
ATOM 1658 CG PHE 346 33.933 69.082 47.683 00 39.31 C
ATOM 1659 CDl PHE 346 34.928 69.532 48.533 00 38.46 C
ATOM 1660 CD2 PHE 346 32.612 69.341 48.005 00 39.08 C
ATOM 1661 CEl PHE 346 34.613 70.227 49.679 00 38.40 C
ATOM 1662 CE2 PHE 346 32.292 70.038 49.152 00 38.30 C
ATOM 1663 CZ PHE 346 33.292 70.480 49.988 00 37.62 C
ATOM 1664 C PHE 346 35.077 68.388 44.089 00 42.77 C
ATOM 1665 O PHE 346 34.077 68.079 43.442 1.00 42.11 O
ATOM 1666 N TYR 347 36.306 68.028 43.727 1.00 45.87 N
ATOM 1667 CA TYR 347 36.507 67.212 42.534 1.00 49.29 C
ATOM 1668 CB TYR 347 36.327 68.040 41.259 1.00 50.71 C
ATOM 1669 CG TYR 347 36.524 67.205 40.011 1.00 53.23 C
ATOM 1670 CDl TYR 347 35.643 66.176 39.697 1.00 54.51 C
ATOM 1671 CEl TYR 347 35.857 65.357 38.598 1.00 55.52 C
ATOM 1672 CD2 TYR 347 37.626 67.398 39.185 1.00 54.18 C
ATOM 1673 CE2 TYR 347 37.848 66.585 38.083 54.53 C
ATOM 1674 CZ TYR 347 36.962 65.566 37.795 55.16 C
ATOM 1675 OH TYR 347 37.181 64.744 36.709 55.99 O
ATOM 1676 C TYR 347 37.841 66.484 42.438 49.84 C
ATOM 1677 O TYR 347 38.886 67.009 42.824 1.00 49.91 O ATOM 1678 N ASN 348 37.777 65.265 41.909 ,00 51.41 N
ATOM 1679 CA ASN 348 38.945 64.418 41.692 00 53.00 C
ATOM 1680 CB ASN 348 39.580 63.991 43.018 .00 52.70 C
ATOM 1681 CG ASN 348 40.890 63.250 42.815 ,00 52.72 C
ATOM 1682 ODl ASN 348 40.933 62.216 42.150 .00 52.32 O
ATOM 1683 ND2 ASN 348 41.969 63.782 43.381 ,00 52.92 N
ATOM 1684 C ASN 348 38.507 63.185 40.908 ,00 54.20 C
ATOM 1685 O ASN 348 37.456 62.607 41.183 ,00 53.70 O
ATOM 1686 N GLN 349 39.313 62.794 39.923 .00 56.43 N
ATOM 1687 CA GLN 349 39.013 61.634 39.084 .00 57.54 C
ATOM 1688 CB GLN 349 40.121 61.440 38.045 ,00 58.89 C
ATOM 1689 CG GLN 349 39.861 60.314 37.058 1.00 61.16 C
ATOM 1690 CD GLN 349 41.012 60.106 36.089 1.00 62.56 C
ATOM 1691 OEl GLN 349 40.939 59.263 35.191 1.00 63.69 O
ATOM 1692 NE2 GLN 349 42.086 60.872 36.268 1.00 61.89 N
ATOM 1693 C GLN 349 38.846 60.357 39.909 1.00 57.34 C
ATOM 1694 O GLN 349 38.032 59.493 39.575 1.00 56.99 O
ATOM 1695 N ASP 350 39.621 60.232 40.980 1.00 57.37 N
ATOM 1696 CA ASP 350 39.524 59.058 41.839 1.00 57.81 C
ATOM 1697 CB ASP 350 40.862 58.774 42.531 1.00 58.04 C
ATOM 1698 CG ASP 350 40.840 57.484 43.333 1.00 58.37 C
ATOM 1699 ODl ASP 350 40.005 57.363 44.254 00 57.83 O
ATOM 1700 OD2 ASP 350 41.656 56.585 43.040 00 59.88 O
ATOM 1701 C ASP 350 38.451 59.325 42.883 00 57.70 C
ATOM 1702 O ASP 350 38.596 60.215 43.724 00 56.39 O
ATOM 1703 N HIS 351 37.373 58.553 42.818 OO 58.06 N
ATOM 1704 CA HIS 351 36.264 58.716 43.744 00 59.11 C
ATOM 1705 CB HIS 351 35.192 57.660 43.464 00 60.17 C
ATOM 1706 CG HIS 351 34.497 57.846 42.151 00 61.54 C
ATOM 1707 CD2 HIS 351 34.655 58.780 41.183 00 61.68 C
ATOM 1708 NDl HIS 351 33.492 57.009 41.711 00 62.00 N
ATOM 1709 CEl HIS 351 33.065 57.419 40.531 00 62.39 C
ATOM 1710 NE2 HIS 351 33.755 58.493 40.187 00 61.99 N
ATOM 1711 C HIS 351 36.682 58.672 45.209 00 58.38 C
ATOM 1712 O HIS 351 36.118 59.384 46.037 00 59.14 O
ATOM 1713 N GLU 352 37.670 57.848 45.536 00 57.44 N
ATOM 1714 CA GLU 352 38.122 57.762 46.920 00 56.44 C
ATOM 1715 CB GLU 352 39.224 56.709 47.072 00 58.12 C
ATOM 1716 CG GLU 352 39.394 56.217 48.503 00 59.92 C
ATOM 1717 CD GLU 352 40.550 55.247 48.662 00 60.96 C
ATOM 1718 OEl GLU 352 41.692 55.706 48.878 00 61.07 O
ATOM 1719 OE2 GLU 352 40.314 54.025 48.561 00 61.39 O
ATOM 1720 C GLU 352 38.648 59.122 47.367 00 54.61 C
ATOM 1721 - O GLU 352 38.309 59.602 48.449 00 53.87 O
ATOM 1722 N LYS 353 39.480 59.736 46.529 00 52.33 N
ATOM 1723 CA LYS 353 40.044 61.045 46.833 OO 51.05 C
ATOM 1724 CB LYS 353 41.029 61.473 45.741 00 52.19 C
ATOM 1725 CG LYS 353 42.243 60.567 45.587 00 54.72 C
ATOM 1726 CD LYS 353 43.159 60.643 46.803 00 56.34 C
ATOM 1727 CE LYS 353 44.378 59.741 46.632 00 57.29 C
ATOM 1728 NZ LYS 353 45.164 60.085 45.409 00 57.74 N
ATOM 1729 C LYS 353 38.900 62.047 46.910 00 49.45 C
ATOM 1730 O LYS 353 38.894 62.932 47.761 00 48.78 O
ATOM 1731 N LEU 354 37.935 61.894 46.008 00 47.58 N
ATOM 1732 CA LEU 354 36.769 62.767 45.966 00 46.17 C
ATOM 1733 CB LEU 354 35.821 62.333 44.848 00 45.92 C
ATOM 1734 CG LEU 354 34.433 62.980 44.832 00 46.02 C
ATOM 1735 CDl LEU 354 34.564 64.498 44.769 00 44.67 C
ATOM 1736 CD2 LEU 354 33.645 62.456 43.543 00 45.38 C
ATOM 1737 C LEU 354 36.038 62.724 47.297 00 45.34 C
ATOM 1738 O LEU 354 35.901 63.744 47.970 00 44.86 O
ATOM 1739 N PHE 355 35.574 61.535 47.672 00 45.16 N
ATOM 1740 CA PHE 355 34.852 61.357 48.925 00 45.48 C
ATOM 1741 CB PHE 355 34.528 59.878 49.155 00 46.10 C
ATOM 1742 CG PHE 355 33.614 59.291 48.117 00 48.52 C
ATOM 1743 CDl PHE 355 32.681 60.082 47.472 1.00 48.59 C
ATOM 1744 CD2 PHE 355 33.668 57.942 47.809 1.00 49.08 C
ATOM 1745 CEl PHE 355 31.819 59.540 46.540 00 49.40 C
ATOM 1746 CE2 PHE 355 32.809 57.395 46.879 00 48.93 C
ATOM 1747 CZ PHE 355 31.883 58.194 46.243 00 49.77 C
ATOM 1748 C PHE 355 35.669 61.895 50.088 0044.08 C
ATOM 1749 O PHE 355 35.121 62.390 51.069 00 44.04 O
ATOM 1750 N GLU 356 36.985 61.796 49.959 1.00 43.68 N ATOM 1751 CA GLU 356 37.911 62.276 50.975 00 43.48 C
ATOM 1752 CB GLU 356 39.345 61.950 50.546 00 46.47 C
ATOM 1753 CG GLU 356 39.971 60.808 51.313 00 50.25 C
ATOM 1754 CD GLU 356 40.315 61.216 52.721 00 52.35 C
ATOM 1755 OEl GLU 356 40.650 60.334 53.537 00 55.05 O
ATOM 1756 OE2 GLU 356 40.256 62.431 53.005 00 53.82 O
ATOM 1757 C GLU 356 37.758 63.785 51.162 00 41.55 C
ATOM 1758 O GLU 356 37.752 64.298 52.283 00 41.14 O
ATOM 1759 N LKU 357 37.640 64.485 50.044 00 38.74 N
ATOM 1760 CA LEU 357 37.488 65.933 50.044 00 38.32 C
ATOM 1761 CB LEU 357 37.651 66.453 48.616 00 36.83 C
ATOM 1762 CG LEU 357 39.002 66.077 47.997 00 37.18 C
ATOM 1763 CDl LEU 357 38.998 66.338 46.504 00 34.81 C
ATOM 1764 CD2 LEU 357 40.103 66.873 48.690 00 35.87 C
ATOM 1765 C LEU 357 36.122 66.333 50.601 00 37.10 C
ATOM 1766 O LEU 357 36.018 67.220 51.443 00 37.88 O
ATOM 1767 N ILE 358 35.079 65.665 50.127 00 36.85 N
ATOM 1768 CA ILE 358 33.718 65.947 50.572 1.00 37.33 C
ATOM 1769 CB ILE 358 32.714 65.009 49.877 36.06 C
ATOM 1770 CG2 ILE 358 31.347 65.094 50.564 36.54 C
ATOM 1771 CGl ILE 358 32.616 65.375 48.392 35.93 C
ATOM 1772 CDl ILE 358 31.764 S4.424 47.579 34.45 C
ATOM 1773 C ILE 358 33.583 65.788 52.081 38.02 C
ATOM 1774 O ILE 358 32.879 66.552 52.736 37.49 O
ATOM 1775 N LEU 359 34.278 64.797 52.629 39.60 N
ATOM 1776 CA LEU 359 34.230 64.528 54.059 41.62 C
ATOM 1777 CB LEU 359 34.570 63.058 54.325 41.16 C
ATOM 1778 CG LEU 359 33.601 61.968 53.865 42.24 C
ATOM 1779 CDl LEU 359 34.228 60.600 54.100 43.07 C
ATOM 1780 CD2 LEU 359 32.295 62.085 54.624 41.63 C
ATOM 1781 C LEU 359 35.142 65.391 54.929 42.49 C
ATOM 1782 O LEU 359 34.766 65.767 56.036 43.03 O
ATOM 1783 N MET 360 36.330 65.723 54.436 44.73 N
ATOM 1784 CA MET 360 37.275 66.478 55.255 46.37 C
ATOM 1785 CB MET 360 38.517 65.611 55.503 48.82 C
ATOM 1786 CG MET 360 38.623 64.999 56.901 50.83 C
ATOM 1787 SD MET 360 37.226 63.975 57.390 52.94 S
ATOM 1788 CE MET 360 36.342 65.113 58.458 52.77 C
ATOM 1789 C MET 360 37.739 67.864 54.807 46.91 C
ATOM 1790 O MET 360 38.095 68.689 55.643 47.08 O
ATOM 1791 N GLU 361 37.732 68.132 53.507 47.61 N
ATOM 1792 CA GLU 361 38.216 69.415 53.0O4 47.30 C
ATOM 1793 CB GLU 361 38.614 69.268 51.533 49.87 C
ATOM 1794 CG GLU 361 39.587 70.327 51.043 53.72 C
ATOM 1795 CD GLU 361 40.968 70.165 51.654 55.82 C
ATOM 1796 OEl GLU 361 41.592 69.102 51.445- 57.31 O
ATOM 1797 OE2 GLU 361 41.430 71.097 52.344 1.00 57.58 O
ATOM 1798 C GLU 361 37.286 70.624 53.144 ,00 46.46 C
ATOM 1799 O GLU 361 36.092 70.547 52.848 00 45.55 O
ATOM 1800 N ASP 362 37.846 71.741 53.601 00 44.97 N
ATOM 1801 CA ASP 362 37.084 72.980 53.727 ,00 46.43 C
ATOM 1802 CB ASP 362 37.756 73.946 54.708 00 48.18 C
ATOM 1803 CG ASP 362 37.598 73.520 56.152 ,00 51.49 C
ATOM 1804 ODl ASP 362 36.444 73.310 56.587 00 52.83 O
ATOM 1805 0D2 ASP 362 38.625 73.401 56.856 ,00 52.46 O
ATOM 1806 C ASP 362 37.076 73.605 52.335 ,00 45.35 C
ATOM 1807 O ASP 362 38.058 73.497 51.599 00 44.88 O
ATOM 1808 N ILE 363 35.977 74.253 51.965 1.00 44.55 N
ATOM 1809 CA ILE 363 35.904 74.869 50.649 .00 43.65 C
ATOM 1810 CB ILE 363 34.443 75.186 50.242 .00 44.75 C
ATOM 1811 CG2 ILE 363 33.825 73.975 49.573 .00 45.98 C
ATOM 1812 CGl ILE 363 33.626 75.608 51.464 .00 45.99 C
ATOM 1813 CDl ILE 363 34.142 76.843 52.169 .00 48.19 C
ATOM 1814 C ILE 363 36.728 76.143 50.531 .00 42.53 C
ATOM 1815 O ILE 363 37.015 76.814 51.523 .00 41.28 O
ATOM 1816 N LYS 364 37.108 76.452 49.298 .00 42.16 N
ATOM 1817 CA LYS 364 37.885 77.638 48.986 .00 42.85 C
ATOM 1818 CB LYS 364 39.166 77.258 48.241 .00 44.01 C
ATOM 1819 CG LYS 364 40.337 76.884 49.139 .00 46.37 C
ATOM 1820 CD LYS 364 40.062 75.661 50.001 .00 48.72 C
ATOM 1821 CE LYS 364 41.361 75.127 50.614 .00 50.07 C
ATOM 1822 NZ LYS 364 41.089 74.072 51.639 .00 50.24 N
ATOM 1823 C LYS 364 37.035 78.554 48.117 1.00 40.93 C ATOM 1824 O LYS 364 36.169 78.091 47.376 1.00 40.69 O
ATOM 1825 N PHE 365 37.297 79.851 48.193 1.00 39.55 N
ATOM 1826 CA PHE 365 36.520 80.816 47.432 1.00 39.51 C
ATOM 1827 CB PHE 365 35.656 81.656 48.376 1.00 37.50 C
ATOM 1828 CG PHE 365 34.641 80.873 49.143 00 36.57 C
ATOM 1829 CDl PHE 365 33.600 80.237 48.491 00 35.31 C
ATOM 1830 CD2 PHE 365 34.706 80.805 50.523 00 35.44 C
ATOM 1831 CEl PHE 365 32.644 79.552 49.200 00 34.59 C
ATOM 1832 CE2 PHE 365 33.752 80.119 51.238 00 36.21 C
ATOM 1833 CZ PHE 365 32.718 79.492 50.576 00 35.24 C
ATOM 1834 C PHE 365 37.354 81.789 46.630 00 39.55 C
ATOM 1835 O PHE 365 38.529 82.010 46.919 00 40.43 O
ATOM 1836 N PRO 366 36.755 82.369 45.583 00 39.35 N
ATOM 1837 CD PRO 366 35.531 81.948 44.881 00 38.12 C
ATOM 1838 CA PRO 366 37.507 83.343 44.793 00 39.08 C
ATOM 1839 CB PRO 366 36.568 83.640 43.632 00 39.05 C
ATOM 1840 CG PRO 366 35.836 82.333 43.455 00 38.33 C
ATOM 1841 C PRO 366 37.603 84.513 45.772 00 39.01 C
ATOM 1842 O PRO 366 36.663 84.753 46.532 00 38.38 O
ATOM 1843 N ARG 367 38.720 85.232 45.774 00 39.22 N
ATOM 1844 CA ARG 367 38.902 86.349 46.704 00 38.77 C
ATOM 1845 CB ARG 367 40.295 86.966 46.516 00 41.79 C
ATOM 1846 CG ARG 367 41.318 86.034 45.876 00 44.51 C
ATOM 1847 CD ARG 367 41.043 85.854 44.386 00 47.47 C
ATOM 1848 NE ARG 367 40.889 84.446 44.023 1.00 49.74 N
ATOM 1849 CZ ARG 367 40.555 84.016 42.810 1.00 51.20 C
ATOM 1850 NHl ARG 367 40.339 84.885 41.831 1.00 53.80 N
ATOM 1851 NH2 ARG 367 40.428 82.717 42.574 1.00 52.61 N
ATOM 1852 C ARG 367 37.844 87.451 46.566 1.00 36.77 C
ATOM 1853 O ARG 367 37.403 88.041 47.560 37.28 O
ATOM 1854 N THR 368 37.433 87.719 45.334 34.07 N
ATOM 1855 CA THR 368 36.452 88.762 45.067 32.83 C
ATOM 1856 CB THR 368 36.525 89.185 43.599 34.13 C
ATOM 1857 OGl THR 368 36.388 88.026 42.766 38.13 O
ATOM 1858 CG2 THR 368 37.871 89.861 43.313 36.45 C
ATOM 1859 C THR 368 34.994 88.430 45.407 31.09 C
ATOM 1860 O THR 368 34.118 89.283 45.261 29.49 O
ATOM 1861 N LEU 369 34.732 87.207 45.858 30.58 N
ATOM 1862 CA LEU 369 33.368 86.814 46.208 29.72 C
ATOM 1863 CB LEU 369 33.311 85.316 46.527 31.11 C
ATOM 1864 CG LEU 369 31.964 84.634 46.264 33.72 C
ATOM 1865 CDl LEU 369 31.673 84.646 44.766 35.02 C
ATOM 1866 CD2 LEU 369 31.998 83.209 46.785 34.67 C
ATOM 1867 C LEU 369 32.952 87.623 47.430 27.51 C
ATOM 1868 O LEU 369 33.743 87.787 48.370 27.74 O
ATOM 1869 N SER 370 31.720 88.127 47.432 24.92 N
ATOM 1870 CA SER 370 31.254 88.943 48.551 21.95 C
ATOM 1871 CB SER 370 29.834 89:478 48.290 23.44 C
ATOM 1872 OG SER 370 28.853 88.446 48.339 21.16 O
ATOM 1873 C SER 370 31.277 88.169 49.850 22.08 C
ATOM 1874 O SER 370 31.287 86.935 49.851 22.82 O
ATOM 1875 N SER 371 31.289 88.900 50.960 18.83 N
ATOM 1876 CA SER 371 31.295 88.287 52.274 23.19 C
ATOM 1877 CB SER 371 31.385 89.368 53.353 21.61 C
ATOM 1878 OG SER 371 31.217 88.800 54.637 26.81 O
ATOM 1879 C SER 371 30.014 87.475 52.466 21.89 C
ATOM 1880 O SER 371 30.048 86.349 52.961 19.47 O
ATOM 1881 N ASP 372 28.883 88.049 52.067 23.34 N
ATOM 1882 CA ASP 372 27.604 87.352 52.205 24.26 C
ATOM 1883 CB ASP 372 26.453 88.268 51.760 25.21 C
ATOM 1884 CG ASP 372 26.087 89.301 52.810 26.34 C
ATOM 1885 ODl ASP 372 26.638 89.249 53.933 28.21 O
ATOM 1886 OD2 ASP 372 25.232 90.165 52.520 27.39 O
ATOM 1887 C ASP 372 27.581 86.047 51.401 22.89 C
ATOM 1888 O ASP 372 27.077 85.030 51.866 24.00 O
ATOM 1889 N ALA 373 28.105 86.081 50.183 24.22 N
ATOM 1890 CA ALA 373 28.146 84.888 49.348 23.24 C
ATOM 1891 CB ALA 373 28.672 85.235 47.957 22.24 C
ATOM 1892 C ALA 373 28.993 83.781 49.975 23.58 C
ATOM 1893 O ALA 373 28.594 82.620 49.974 20.52 O
ATOM 1894 N LYS 374 30.159 84.130 50.515 25.47 N
ATOM 1895 CA LYS 374 31.018 83.129 51.147 26.47 C
ATOM 1896 CB LYS 374 32.363 83.747 51.556 1.00 27.53 C ATOM 1897 CG LYS 374 33.234 84.204 50.386 1.00 30.52 C
ATOM 1898 CD LYS 374 34.518 84.864 50.905 1.00 33.83 C
ATOM 1899 CE LYS 374 35.346 85.470 49.785 1.00 35.15 C
ATOM 1900 NZ LYS 374 36.567 86.146 50.322 1.00 36.73 N
ATOM 1901 C LYS 374 30.322 82.547 52.376 1.00 24.83 C
ATOM 1902 O LYS 374 30.408 81.351 52.642 1.00 24.46 O
ATOM 1903 N SER 375 29.639 83.407 53.123 00 24.52 N
ATOM 1904 CA SER 375 28.908 82.988 54.310 00 25.04 C
ATOM 1905 CB SER 375 28.262 84.202 54.983 00 24.06 C
ATOM 1906 OG SER 375 27.435 83.801 56.062 00 29.43 O
ATOM 1907 C SER 375 27.815 81.979 53.939 00 23.26 C
ATOM 1908 O SER 375 27.667 80.931 54.577 00 22.01 O
ATOM 1909 N LEU 376 27.048 82.305 52.909 00 22.27 N
ATOM 1910 CA LEU 376 25.968 81.430 52.463 00 22.59 C
ATOM 1911 CB LEU 376 25.204 82.073 51.301 00 22.34 C
ATOM 1912 CG LEU 376 24.119 81.168 50.710 00 22.24 C
ATOM 1913 CDl LEU 376 22.946 81.138 51.664 00 24.91 C
ATOM 1914 CD2 LEU 376 23.672 81.676 49.343 00 23.96 C
ATOM 1915 C LEU 376 26.500 80.066 52.010 00 22.74 C
ATOM 1916 O LEU 376 26.035 79.023 52.466 00 21.14 O
ATOM 1917 N LEU 377 27.472 80.079 51.102 00 24.02 N
ATOM 1918 CA LEU 377 28.035 78.837 50.585 00 24.80 C
ATOM 1919 CB LEU 377 29.025 79.135 49.454 00 24.14 C
ATOM 1920 CG LEU 377 28.408 79.797 48.211 00 22.75 C
ATOM 1921 CDl LEU 377 29.488 80.062 47.166 00 22.89 C
ATOM 1922 CD2 LEU 377 27.318 78.896 47.633 00 23.84 C
ATOM 1923 C LEU 377 28.698 78.000 51.674 00 26.35 C
ATOM 1924 O LEU 377 28.565 76.780 51.680 00 26.69 O
ATOM 1925 N SER 378 29.397 78.649 52.602 1.00 27.29 N
ATOM 1926 CA SER 378 30.048 77.922 53.688 1.00 26.64 C
ATOM 1927 CB SER 378 30.926 78.854 54.526 1.00 28.04 C
ATOM 1928 OG SER 378 32.051 79.303 53.800 1.00 30.67 O
ATOM 1929 C SER 378 28.988 77.301 54.585 1.00 26.08 C
ATOM 1930 O SER 378 29.138 76.173 55.059 1.00 25.28 O
ATOM 1931 N GLY 379 27.910 78.041 54.815 25.00 N
ATOM 1932 CA GLY 379 26.849 77.531 55.659 23.37 C
ATOM 1933 C GLY 379 26.136 76.336 55.062 23.58 C
ATOM 1934 O GLY 379 25.863 75.349 55.766 23.63 O
ATOM 1935 N LEU 380 25.825 76.425 53.772 22.36 N
ATOM 1936 CA LEU 380 25.137 75.352 53.065 22.36 C
ATOM 1937 CB LEU 380 24.734 75.812 51.652 21.02 C
ATOM 1938 CG LEU 380 23.672 76.920 51.551 20.19 C
ATOM 1939 CDl LEU 380 23.529 77.390 50.106 20.75 C
ATOM 1940 CD2 LEU 380 22.340 76.402 52.073 21.65 C
ATOM 1941 C LEU 380 26.027 74.121 52.956 23.05 C
ATOM 1942 O LEU 380 25.533 72.991 52.857 22.18 O
ATOM 1943 N LEU 381 27.339 74.339 52.984 24.34 N
ATOM 1944 CA LEU 381 28.280 73.239 52.858 26.08 C
ATOM 1945 CB LEU 381 29.363 73.594 51.828 27.04 C
ATOM 1946 CG LEU 381 28.798 73.792 50.411 26.65 C
ATOM 1947 CDl LEU 381 29.919 74.079 49.433 28.38 C
ATOM 1948 CD2 LEU 381 28.020 72.552 49.987 28.19 C
ATOM 1949 C LEU 381 28.913 72.750 54.155 26.73 C
ATOM 1950 O LEU 381 29.964 72.107 54.137 27.46 O
ATOM 1951 N ILE 382 28.271 73.052 55.278 1.00 25.75 N
ATOM 1952 CA ILE 382 28.744 72.590 56.580 27.31 C
ATOM 1953 CB ILE 382 27.873 73.201 57.713 27.14 C
ATOM 1954 CG2 ILE 382 27.947 72.345 58.976 28.05 C
ATOM 1955 CGl ILE 382 28.328 74.639 57.976 27.33 C
ATOM 1956 CDl ILE 382 27.401 75.450 58.854 26.23 C
ATOM 1957 C ILE 382 28.612 71.059 56.540 28.73 C
ATOM 1958 O ILE 382 27.596 70.541 56.096 29.50 O
ATOM 1959 N LYS 383 29.641 70.340 56.986 29.33 N
ATOM 1960 CA LYS 383 29.638 68.877 56.944 31.36 C
ATOM 1961 CB LYS 383 31.000 68.340 57.400 32.40 C
ATOM 1962 CG LYS 383 32.169 68.871 56.582 35.91 C
ATOM 1963 CD LYS 383 32.036 68.472 55.125 35.97 C
ATOM 1964 CE LYS 383 33.046 69.198 54.256 37.56 C
ATOM 1965 NZ LYS 383 34.400 69.106 54.826 38.51 N
ATOM 1966 C LYS 383 28.542 68.198 57.753 30.53 C
ATOM 1967 O LYS 383 27.886 67.274 57.271 30.29 O
ATOM 1968 N ASP 384 28.372 68.644 58.990 32.08 N
ATOM 1969 CA ASP 384 27.364 68.091 59.885 1.00 33.09 C ATOM 1970 CB ASP 384 27.700 68.492 61.325 1.00 33.62 C
ATOM 1971 CG ASP 384 26.729 67.917 62.337 1.00 36.93 C
ATOM 1972 ODl ASP 384 25.836 67.145 61.937 1.00 37.63 O
ATOM 1973 OD2 ASP 384 26.867 68.238 63.540 1.00 39.58 O
ATOM 1974 C ASP 384 26.000 68.634 59.472 1.00 32.49 C
ATOM 1975 O ASP 384 25.744 69.835 59.568 .00 33.34 O
ATOM 1975 N PRO 385 25.107 67.754 58.998 .00 32.14 N
ATOM 1977 CD PRO 385 25.324 66.307 58.850 .00 32.61 C
ATOM 1978 CA PRO 385 23.758 68.122 58.555 .00 32.48 C
ATOM 1979 CB PRO 385 23.172 66.793 58.087 .00 32.69 C
ATOM 1980 CG PRO 385 23.920 65.777 58.905 .00 32.04 C
ATOM 1981 C PRO 385 22.878 68.807 59.592 .00 33.15 C
ATOM 1982 O PRO 385 21.931 69.519 59.241 .00 32.37 O
ATOM 1983 N ASN 386 23.185 68.593 60.866 1.00 33.01 N
ATOM 1984 CA ASN 386 22.404 69.199 61.929 1.00 34.35 C
ATOM 1985 CB ASN 386 22.567 68.397 63.222 1.00 37.21 C
ATOM 1986 CG ASN 386 22.240 66.937 63.036 00 40.07 C
ATOM 1987 ODl ASN 386 23.080 66.154 62.591 00 44.63 O
ATOM 1988 ND2 ASN 386 21.010 66.560 63.352 00 39.95 N
ATOM 1989 C ASN 386 22.801 70.648 62.166 00 32.82 C
ATOM 1990 O ASN 386 22.004 71.435 62.672 00 33.27 O
ATOM 1991 N LYS 387 24.027 70.995 61.791 00 31.67 N
ATOM 1992 CA LYS 387 24.541 72.349 61.968 00 30.92 C
ATOM 1993 CB LYS 387 25.953 72.284 62.553 00 32.50 C
ATOM 1994 CG LYS 387 25.989 71.649 63.935 00 36.63 C
ATOM 1995 CD LYS 387 27.367 71.724 64.558 00 39.63 C
ATOM 1996 CE LYS 387 27.326 71.224 65.996 00 42.44 C
ATOM 1997 NZ LYS 387 28.672 71.224 66.619 1.00 45.84 N
ATOM 1998 C LYS 387 24.560 73.164 60.672 28.70 C
ATOM 1999 O LYS 387 24.847 74.359 60.678 28.45 O
ATOM 2000 N ARG 388 24.254 72.503 59,.566 27.05 N
ATOM 2001 CA ARG 388 24.234 73.142 58.255 26.28 C
ATOM 2002 CB ARG 388 24.044 72.068 57.193 27.86 C
ATOM 2003 CG ARG 388 24.498 72.467 55.811 29.48 C
ATOM 2004 CD ARG 388 25.200 71.273 55.190 31.49 C
ATOM 2005 NE ARG 388 24.252 70.225 54.881 31.08 N
ATOM 2006 CZ ARG 388 24.522 68.926 54.871 27.75 C
ATOM 2007 NHl ARG 388 25.736 68.465 55.164 30.39 N
ATOM 2008 NH2 ARG 388 23.559 68.086 54.550 30.42 N
ATOM 2009 C ARG 388 23.118 74.171 58.140 25.88 C
ATOM 2010 O ARG 388 22.086 74.048 58.793 27.04 O
ATOM 2011 N LEU 389 23.326 75.179 57.297 24.31 N
ATOM 2012 CA LEU 389 22.332 76.220 57.085 24.30 C
ATOM 2013 CB LEU 389 22.889 77.298 56.140 21.85 C
ATOM 2014 CG LEU 389 22.015 78.532 55.915 21.23 C
ATOM 2015 CDl LEU 389 21.892 79.310 57.238 21.61 C
ATOM 2016 CD2 LEU 389 22.642 79.415 54.844 24.15 C
ATOM 2017 C LEU 389 21.101 75.546 56.475 22.69 C
ATOM 2018 O LEU 389 21.209 74.861 55.458 23.80 O
ATOM 2019 N GLY 390 19.944 75.733 57.109 24.36 N
ATOM 2020 CA GLY 390 18.716 75.114 56.640 22.73 C
ATOM 2021 C GLY 390 18.433 73.775 57.316 26.22 C
ATOM 2022 O GLY 390 17.363 73.184 57.130 24.19 O
ATOM 2023 N GLY 391 19.398 73.295 58.095 25.06 N
ATOM 2024 CA GLY 391 19.262 72.017 58.780 27.62 C
ATOM 2025 C GLY 391 18.472 72.059 60.079 26.99 C
ATOM 2026 O GLY 391 18.086 71.016 60.612 27.75 O
ATOM 2027 N GLY 392 18.235 73.261 60.588 27.22 N
ATOM 2028 CA GLY 392 17.479 73.420 61.821 28.88 C
ATOM 2029 C GLY 392 15.988 73.220 61.619 28.14 C
ATOM 2030 O GLY 392 15.537 72.945 60.505 28.25 O
ATOM 2031 N PRO 393 15.183 73.373 62.678 28.27 N
ATOM 2032 CD PRO 393 15.577 73.791 64.036 27.18 C
ATOM 2033 CA PRO 393 13.728 73.192 62.591 28.10 C
ATOM 2034 CB PRO 393 13.284 73.299 64.052 28.70 C
ATOM 2035 CG PRO 393 14.259 74.248 64.623 27.42 C
ATOM 2036 C PRO 393 12.936 74.126 61.671 27.50 C
ATOM 2037 O PRO 393 11.833 73.777 61.246 26.28 O
ATOM 2038 N ASP 394 13.478 75.301 61.356 26.36 N
ATOM 2039 CA ASP 394 12.759 76.233 60.481 24.94 C
ATOM 2040 CB ASP 394 13.079 77.676 60.879 25.10 C
ATOM 2041 CG ASP 394 11.849 78.573 60.869 25.99 C
ATOM 2042 ODl ASP 394 10.724 78.046 60.750 1.00 26.28 O ATOM 2043 OD2 ASP 394 12.004 79.804 60.990 1.00 28.06 O
ATOM 2044 C ASP 394 13.092 75.985 58.999 1.00 25.34 C
ATOM 2045 O ASP 394 12.628 76.694 58.112 .00 24.01 O
ATOM 2046 N ASP 395 13.909 74.968 58.755 .00 25.35 N
ATOM 2047 CA ASP 395 14.287 74.558 57.406 .00 25.87 C
ATOM 2048 CB ASP 395 13.159 73.705 56.804 .00 27.64 C
ATOM 2049 CG ASP 395 13.595 72.952 55.551 .00 27.25 C
ATOM 2050 ODl ASP 395 14.589 72.201 55.621 .00 28.09 O
ATOM 2051 OD2 ASP 395 12.941 73.108 54.504 .00 27.73 O
ATOM 2052 C ASP 395 14.640 75.707 56.457 .00 24.90 C
ATOM 2053 O ASP 395 15.559 76.475 56.724 .00 23.19 O
ATOM 2054 N ALA 396 13.906 75.814 55.351 .00 23.31 N
ATOM 2055 CA ALA 396 14.150 76.852 54.349 .00 24.06 C
ATOM 2056 CB ALA 396 13.091 76.779 53.251 .00 26.27 C
ATOM 2057 C ALA 396 14.217 78.279 54.895 .00 24.42 C
ATOM 2058 O ALA 396 14.986 79.098 54.396 .00 25.17 O
ATOM 2059 N LYS 397 13.413 78.582 55.909 .00 24.92 N
ATOM 2060 CA LYS 397 13.407 79.924 56.484 .00 25.17 C
ATOM 2061 CB LYS 397 12.443 80.000 57.675 .00 28.26 C
ATOM 2062 CG LYS 397 10.973 80.159 57.300 .00 31.66 C
ATOM 2063 CD LYS 397 10.486 79.090 56.350 1.00 36.68 C
ATOM 2064 CE LYS 397 9.074 79.416 55.861 39.91 C
ATOM 2065 NZ LYS 397 8.610 78.473 54.804 40.97 N
ATOM 2066 C LYS 397 14.792 80.392 56.926 23.92 C
ATOM 2067 O LYS 397 15.081 81.586 56:887 21.50 O
ATOM 2068 N GLU 398 15.635 79.462 57.365 24.43 N
ATOM 2069 CA GLU 398 16.991 79.819 57.792 24.29 C
ATOM 2070 CB GLU 398 17.771 78.590 58.254 24.94 C
ATOM 2071 CG GLU 398 17.339 77.978 59.570 27.43 C
ATOM 2072 CD GLU 398 18.363 76.975 60.084 29.59 C
ATOM 2073 OEl GLU 398 18.027 76.175 60.979 32.95 O
ATOM 2074 OE2 GLU 398 19.517 76.996 59.600 28.89 O
ATOM 2075 C GLU 398 17.756 80.448 56.631 22.95 C
ATOM 2076 O GLU 398 18.518 81.400 56.811 22.79 O
ATOM 2077 N ILE 399 17.574 79.887 55.443 22.32 N
ATOM 2078 CA ILE 399 18.245 80.407 54.258 22.75 C
ATOM 2079 CB ILE 399 18.232 79.362 53.108 21.29 i C
ATOM 2080 CG2 ILE 399 18.473 80.041 51.780 22.25 C
ATOM 2081 CGl ILE 399 19.329 78.315 53.332 25.13 C
ATOM 2082 CDl ILE 399 18.846 77.007 53.889 27.07 C
ATOM 2083 C ILE 399 17.558 81.691 53.807 20.46 C
ATOM 2084 O ILE 399 18.208 82.680 53.480 19.66 O
ATOM 2085 N MET 400 16.228 81.686 53.806 20.41 N
ATOM 2086 CA MET 400 15.486 82.866 53.390 20.84 C
ATOM 2087 CB MET 400 13.986 82.593 53.506 20.46 C
ATOM 2088 CG MET 400 13.541 81.437 52.621 1.00 25.71 C
ATOM 2089 SD MET 400 11.805 80.950 52.866 30.58 S
ATOM 2090 CE MET 400 11.025 82.394 52.439 29.10 C
ATOM 2091 C MET 400 15.868 84.119 54.181 19.64 C
ATOM 2092 O MET 400 15.799 85.234 53.657 20.05 O
ATOM 2093 N ARG 401 16.284 83.931 55.432 21.89 N
ATOM 2094 CA ARG 401 16.687 85.044 56.292 22.59 C
ATOM 2095 CB ARG 401 16.305 84.778 57.759 23.68 C
ATOM 2096 CG ARG 401 14.805 84.798 58.021 25.85 C
ATOM 2097 CD ARG 401 14.477 84.733 59.510 28.32 C
ATOM 2098 HE ARG 401 14.299 83.371 60.001 33.79 N
ATOM 2099 CZ ARG 401 15.264 82.607 60.487 33.47 C
ATOM 2100 NHl ARG 401 16.510 83.068 60.560 38.24 N
ATOM 2101 NH2 ARG 401 14.980 81.375 60.894 33.92 N
ATOM 2102 C ARG 401 18.178 85.353 56.234 22.00 C
ATOM 2103 O ARG 401 18.634 86.320 56.846 22.51 O
ATOM 2104 N HIS 402 18.939 84.549 55.505 22.13 N
ATOM 2105 CA HIS 402 20.381 84.791 55.413 22.05 C
ATOM 2106 CB HIS 402 21.064 83.645 54.652 22.76 C
ATOM 2107 CG HIS 402 22.560 83.687 54.721 20.41 C
ATOM 2108 CD2 HIS 402 23.427 83.093 55.573 21.29 C
ATOM 2109 NDl HIS 402 23.323 84.471 53.882 21.49 N
ATOM 2110 CEl HIS 402 24.597 84.357 54.215 21.83 C
ATOM 2111 NE2 HIS 402 24.687 83.527 55.239 20.91 N
ATOM 2112 C HIS 402 20.691 86.136 54.739 22.11 C
ATOM 2113 O HIS 402 19.975 86.562 53.831 21.99 O
ATOM 2114 N SER 403 21.758 86.804 55.185 22.25 N
ATOM 2115 CA SER 403 22.145 88.100 54.621 1.00 21.09 C ATOM 2116 CB SER 403 23.471 88.575 55.244 00 25.82 C
ATOM 2117 OG SER 403 24.548 87.749 54.829 00 29.47 O
ATOM 2118 C SER 403 22.260 88.109 53.086 00 18.69 C
ATOM 2119 O SER 403 21.909 89.103 52.440 00 19.23 O
ATOM 2120 N PHE 404 22.745 87.020 52.491 00 17.74 N
ATOM 2121 CA PHE 404 22.863 86.974 51.028 00 17.94 C
ATOM 2122 CB PHE 404 23.370 85.609 50.569 00 19.38 C
ATOM 2123 CG PHE 404 23.625 85.532 49.097 00 20.01 C
ATOM 2124 CDl PHE 404 24.754 86.113 48.550 00 21.63 C
ATOM 2125 CD2 PHE 404 22.727 84.898 48.251 00 18.22 .C
ATOM 2126 CEl PHE 404 24.986 86.062 47.181 1.00 22.23 C
ATOM 2127 CE2 PHE 404 22.953 84.843 46.887 1.00 22.91 C
ATOM 2128 CZ PHE 404 24.092 85.430 46.352 00 24.39 C
ATOM 2129 C PHE 404 21.524 87.249 50.321 00 19.42 C
ATOM 2130 O PHE 404 21.487 87.761 49.193 00 18.19 O
ATOM 2131 N PHE 405 20.429 86.894 50.979 00 18.64 N
ATOM 2132 CA PHE 405 19.101 87.096 50.397 00 20.36 C
ATOM 2133 CB PHE 405 18.273 85.826 50.563 00 20.00 C
ATOM 2134 CG PHE 405 18.724 84.683 49.696 00 18.88 C
ATOM 2135 CDl PHE 405 18.513 84.709 48.325 00 18.06 C
ATOM 2136 CD2 PHE 405 19.319 83.565 50.257 1.00 17.74 C
ATOM 2137 CEl PHE 405 18.884 83.637 47.531 18.15 C
ATOM 2138 CE2 PHE 405 19.695 82.476 49.462 18.68 C
ATOM 2139 CZ PHE 405 19.477 82.513 48.105 20.49 C
ATOM 2140 C PHE 405 18.351 88.276 51.016 23.90 C
ATOM 2141 O PHE 405 17.118 88.357 50.937 22.31 O
ATOM 2142 N SER 406 19.081 89.178 51.659 23.00 N
ATOM 2143 CA SER 406 18.435 90.332 52.256 27.47 C
ATOM 2144 CB SER 406 19.432 91.133 53.096 27.62 C
ATOM 2145 OG SER 406 20.334 91.810 52.248 27.54 O
ATOM 2146 C SER 406 18.011 91.133 51.030 29.79 C
ATOM 2147 O SER 406 18.778 91.280 50.084 35.91 O
ATOM 2148 N GLY 407 16.800 91.648 51.017 28.78 N
ATOM 2149 CA GLY 407 16.393 92.384 49.835 27.10 C
ATOM 2150 C GLY 407 15.439 91.585 48.965 25.37 C
ATOM 2151 O GLY 407 14.766 92.144 48.103 27.98 O
ATOM 2152 N VAL 408 15.365 90.278 -49.194 22.46 N
ATOM 2153 CA VAL 408 14.477 89.434 48.412 21.32 C
ATOM 2154 CB VAL 408 15.025 87.987 48.289 22.87 C
ATOM 2155 CGl VAL 408 13.971 87.077 47.657 21.39 C
ATOM 2156 CG2 VAL 408 16.286 87.974 47.415 23.17 C
ATOM 2157 C VAL 408 13.097 89.376 49.057 20.60 C
ATOM 2158 O VAL 408 12.984 89.211 50.274 20.89 O
ATOM 2159 N ASN 409 12.050 89.566 48.253 21.96 N
ATOM 2160 CA ASN 409 10.684 89.454 48.777 20.82 C
ATOM 2161 CB ASN 409 ■ 9.759 90.518 48.164 22.73 C
ATOM 2162 CG ASN 409 8.336 90.422 48.698 21.84 C
ATOM 2163 ODl ASN 409 7.655 89.438 48.462 22.15 O
ATOM 2164 ND2 ASN 409 7.898 91.434 49.435 25.83 N
ATOM 2165 C ASN 409 10.269 88.035 48.367 18.70 C
ATOM 2166 O ASN 409 10.115 87.731 47.180 18.29 O
ATOM 2167 N TRP 410 10.113 87.161 49.354 17.79 N
ATOM 2168 CA TRP 410 9.804 85.770 49.073 21.40 C
ATOM 2169 CB TRP 410 10.088 84.929 50.322 22.80 C
ATOM 2170 CG TRP 410 11.578 84.914 50.619 22.51 C
ATOM 2171 CD2 TRP 410 12.566 84.100 49.972 21.68 C
ATOM 2172 CE2 TRP 410 13.833 84.540 50.420 20.35 C
ATOM 2173 CE3 TRP 410 12.504 83.048 49.046 21.42 C
ATOM 2174 CDl TRP 410 12.267 85.780 51.424 22.84 C
ATOM 2175 NEl TRP 410 13.625 85.563 51.306 22.27 N
ATOM 2176 CZ2 TRP 410 15.023 83.965 49.973 1.00 20.81 C
ATOM 2177 CZ3 TRP 410 13.695 82.476 48.604 22.35 C
ATOM 2178 CH2 TRP 410 14.932 82.938 49.066 21.20 C
ATOM 2179 C TRP 410 8.431 85.472 48.486 21.44 C
ATOM 2180 O TRP 410 8.255 84.469 47.801 22.47 O
ATOM 2181 N GLN 411 7.454 86.333 48.734 24.13 N
ATOM 2182 CA GLN 411 6.148 86.088 48.124 24.35 C
ATOM 2183 CB GLN 411 5.059 86.990 48.718 25.95 C
ATOM 2184 CG GLN 411 3.673 86.683 48.131 29.36 C
ATOM 2185 CD GLN 411 3.214 85.273 48.461 29.52 C
ATOM 2186 OEl GLN 411 2.662 84.564 47.617 34.08 O
ATOM 2187 NE2 GLN 411 3.445 84.859 49.695 34.97 N
ATOM 2188 C GLN 411 6.337 86.394 46.638 1.00 23.62 C ATOM 2189 O GLN 411 5,823 85.679 45.780 1.00 24.15 O
ATOM 2190 N ASP 412 7.093 87.452 46.332 1.00 23.83 N
ATOM 2191 CA ASP 412 7.35,8 87.803 44.939 1.00 23.83 C
ATOM 2192 CB ASP 412 8.179 89.090 44.829 00 23.81 C
ATOM 2193 CG ASP 412 7.338 90.329 44.994 00 26.49 C
ATOM 2194 ODl ASP 412 6.096 90.206 44.951 00 23.80 O
ATOM 2195 OD2 ASP 412 7.917 91.421 45.154 00 25.59 O
ATOM 2196 C ASP 412 8.099 86.679 44.220 00 23.81 C
ATOM 2197 O ASP 412 7.897 86.462 43.028 00 24.87 O
ATOM 2198 N VAL 413 8.966 85.970 44.937 00 23.72 N
ATOM 2199 CA VAL 413 9.702 84.866 44.328 00 23.42 C
ATOM 2200 CB VAL 413 10.654 84.186 45.339 00 24.19 C
ATOM 2201 CGl VAL 413 11.250 82.919 44.711 00 22.78 C
ATOM 2202 CG2 VAL 413 11.773 85.167 45.748 00 24.24 C
ATOM 2203 C VAL 413 8.713 83.824 43.812 1.00 24.19 C
ATOM 2204 O VAL 413 8.723 83.465 42.633 1.00 24.41 O
ATOM 2205 N TYR 414 7.850 83.352 44.704 1.00 26.06 N
ATOM 2206 CA TYR 414 6.837 82.358 44.354 1.00 26.78 C
ATOM 2207 CB TYR 414 5.979 82.040 45.585 1.00 27.19 C
ATOM 2208 CG TYR 414 4.967 80.942 45.361 .00 30.54 C
ATOM 2209 CDl TYR 414 5.313 79.604 45.528 .00 31.47 C
ATOM 2210 CEl TYR 414 4.390 78.590 45.305 .00 32.84 C
ATOM 2211 CD2 TYR 414 3.671 81.240 44.962 .00 30.04 C
ATOM 2212 CE2 TYR 414 2.746 80.240 44.733 .00 33.11 C
ATOM 2213 CZ TYR 414 3.108 78.917 44.907 .00 32.92 C
ATOM 2214 OH TYR 414 2.186 77.925 44.678 .00 35.47 O
ATOM 2215 C TYR 414 5.930 82.829 43.206 .00 26.97 C
ATOM 2216 O TYR 414 5.630 82.062 42.284 .00 27.42 O
ATOM 2217 N ASP 415 5.502 84.088 43.259 .00 27.17 N
ATOM 2218 CA ASP 415 4.613 84.635 42.231 .00 27.31 C
ATOM 2219 CB ASP 415 3.854 85.852 42.785 .00 26.90 C
ATOM 2220 CG ASP 415 2.928 85.478 43.926 .00 28.97 C
ATOM 2221 ODl ASP 415 2.476 84.319 43.950 .00 32.04 O
ATOM 2222 OD2 ASP 415 2.646 86.324 44.791 .00 28.58 O
ATOM 2223 C ASP 415 5.279 84.999 40.909 .00 28.50 C
ATOM 2224 O ASP 415 4.630 85.531 40.004 .00 28.04 O
ATOM 2225 N LYS 416 6.567 84.695 40.793 .00 27.29 N
ATOM 2226 CA LYS 416 7.336 84.983 39.590 .00 28.29 C
ATOM 2227 CB LYS 416 6.832 84.122 38.421 .00 29.45 C
ATOM 2228 CG LYS 416 7.076 82.627 38.638 .00 31.06 C
ATOM 2229 CD LYS 416 7.025 81.812 37.345 .00 34.75 C
ATOM 2230 CE LYS 416 5.653 81.793 36.704 .00 35.77 C
ATOM 2231 NZ LYS 416 5.697 81.164 35.339 .00 37.54 N
ATOM 2232 C LYS 416 7.327 86.463 39.220 .00 27.09 C
ATOM 2233 O LYS 416 7.212 86.832 38.050 .00 27.67 O
ATOM 2234 N LYS 417 7.469 87.308 40.237 .00 28.96 N
ATOM 2235 CA LYS 417 7.487 88.750 40.056 .00 28.73 C
ATOM 2236 CB LYS 417 6.637 89.418 41.140 .00 30.50 C
ATOM 2237 CG LYS 417 5.133 89.135 40.998 .00 30.63 C
ATOM 2238 CD LYS 417 4.332 89.805 42.095 .00 32.76 C
ATOM 2239 CE LYS 417 2.848 89.418 42.030 .00 33.83 C
ATOM 2240 NZ LYS 417 2.071 90.057 43.136 .00 33.38 N
ATOM 2241 C LYS 417 8.910 89.329 40.049 .00 30.21 C
ATOM 2242 O LYS 417 9.099 90.527 39.856 .00 31.98 O
ATOM 2243 N LEU 418 9.915 88.494 40.282 .00 30.56 N
ATOM 2244 CA LEU 418 11.287 88.989 40.222 .00 30.53 C
ATOM 2245 CB LEU 418 12.241 88.076 40.992 .00 33.99 C
ATOM 2246 CG LEU 418 12.550 88.433 42.451 .00 37.09 C
ATOM 2247 CDl LEU 418 11.277 88.692 43.206 .00 37.89 C
ATOM 2248 CD2 LEU 418 13.337 87.308 43.086 .00 38.90 C
ATOM 2249 C LEU 418 11.649 88.975 38.740 .00 30.13 C
ATOM 2250 O LEU 418 11.255 88.064 38.013 .00 28.09 O
ATOM 2251 N VAL 419 12.392 89.975 38.285 .00 30.28 N
ATOM 2252 CA VAL 419 12.771 90.031 36.878 .00 30.29 C
ATOM 2253 CB VAL 419 13.107 91.476 36.457 .00 31.25 C
ATOM 2254 CGl VAL 419 13.382 91.534 34.955 .00 32.04 C
ATOM 2255 CG2 VAL 419 11.938 92.402 36.822 .00 32.36 C
ATOM 2256 C VAL 419 13.974 89.138 36.600 .00 29.31 C
ATOM 2257 O VAL 419 15.030 89.299 37.209 .00 28.19 O
ATOM 2258 N PRO 420 13.823 88.167 35.685 1.00 29.80 N
ATOM 2259 CD PRO 420 12.594 87.752 34.983 1.00 28.85 C
ATOM 2260 CA PRO 420 14.941 87.271 35.367 1.00 30.26 C
ATOM 2261 CB PRO 420 14.336 86.309 34.344 1.00 29.94 C ATOM 2262 CG PRO 420 12.864 86.292 34.712 1.00 32.39 C
ATOM 2263 C PRO 420 16.120 88.061 34.792 1.00 31.22 C
ATOM 2264 O PRO 420 15.942 88.912 33.922 1.00 30.61 O
ATOM 2265 N PRO 421 17.337 87.781 35.274 1.00 30.68 N
ATOM 2266 CD PRO 421 17.625 86.800 36.333 1.00 32.81 C
ATOM 2267 CA PRO 421 18.568 88.442 34.835 1.00 31.81 C
ATOM 2268 CB PRO 421 19.596 87.954 35.850 1.00 31.23 C
ATOM 2269 CG PRO 421 19.115 86.584 36.161 1.00 33.47 C
ATOM 2270 C PRO 421 18.955 88.100 33.404 1.00 31.91 C
ATOM 2271 O PRO 421 19.615 88.889 32.729 1.00 34.35 O
ATOM 2272 N PHE 422 18.547 86.919 32.953 1.00 30.97 N
ATOM 2273 CA PHE 422 18.829 86.469 31.601 1.00 32.85 C
ATOM 2274 CB PHE 422 19.816 85.299 31.613 1.00 32.96 C
ATOM 2275 CG PHE 422 19.983 84.643 30.269 1.00 34.89 C
ATOM 2276 CDl PHE 422 20.695 85.272 29.257 1.00 35.48 C
ATOM 2277 CD2 PHE 422 19.399 83.413 30.009 1.00 35.44 C
ATOM 2278 CEl PHE 422 20.821 84.686 28.008 1.00 36.53 C
ATOM 2279 CE2 PHE 422 19.520 82.820 28.766 1.00 37.73 C
ATOM 2280 CZ PHE 422 20.232 83.458 27.762 1.00 36.99 C
ATOM 2281 C PHE 422 17.528 86.024 30.948 1.00 33.20 C
ATOM 2282 O PHE 422 16.839 85.153 31.469 1.00 32.89 O
ATOM 2283 N LYS 423 17.203 86.625 29.807 1.00 34.22 N
ATOM 2284 CA LYS 423 15.985 86.303 29.075 1.00 36.29 C
ATOM 2285 CB LYS 423 15.321 87.592 28.583 1.00 39.00 C
ATOM 2286 CG LYS 423 13.858 87.735 28.973 1.00 43.15 C
ATOM 2287 CD LYS 423 13.019 86.570 28.461 1.00 45.01 C
ATOM 2288 CE LYS 423 12.994 86.511 26.945 1.00 47.06 C
ATOM 2289 NZ LYS 423 12.224 85.330 26.443 1.00 47.94 N
ATOM 2290 C LYS 423 16.295 85.407 27.879 1.00 37.00 C
ATOM 2291 O LYS 423 16.909 85.851 26.908 1.00 37.20 O
ATOM 2292 N PRO 424 15.880 84.130 27.934 1.00 36.27 N
ATOM 2293 CD PRO 424 15.220 83.430 29.051 1.00 36.03 C
ATOM 2294 CA PRO 424 16.142 83.214 26.821 1.00 37.45 C
ATOM 2295 CB PRO 424 15.433 81.932 27.257 1.00 35.91 C
ATOM 2296 CG PRO 424 15.558 81.979 28.762 1.00 34.33 C
ATOM 2297 C PRO 424 15.578 83.789 25.520 1.00 38.69 C
ATOM 2298 O PRO 424 14.450 84.281 25.485 1.00 38.11 O
ATOM 2299 N GLN 425 16.367 83.737 24.454 1.00 40.99 N
ATOM 2300 CA GLN 425 15.926 84.275 23.170 1.00 43.98 C
ATOM 2301 CB GLN 425 17.127 84.824 22.392 1.00 44.95 C
ATOM 2302 CG GLN 425 17.831 85.982 23.089 1.00 46.71 C
ATOM 2303 CD GLN 425 16.905 87.159 23.333 1.00 48.63 C
ATOM 2304 OEl GLN 425 16.382 87.758 22.393 1.00 50.09 O
ATOM 230S NE2 GLN 425 16.695 87.494 24.601 1.00 49.63 N
ATOM 2305 C GLN 425 15.179 83.254 22.318 1.00 44.51 C
ATOM 2307 O GLN 425 15.742 82.677 21.387 1.00 44.87 O
ATOM 2308 N VAL 426 13.907 83.039 22.644 1.00 45.61 N
ATOM 2309 CA VAL 426 13.074 82.100 21.903 1.00 46.60 C
ATOM 2310 CB VAL 42S 12.442 81.046 22.837 1.00 46.05 C
ATOM 2311 CGl VAL 426 13.537 80.227 23.512 1.00 45.48 C
ATOM 2312 CG2 VAL 426 11.569 81.726 23.874 1.00 46.38 C
ATOM 2313 C VAL 426 11.961 82.860 21.187 1.00 48.49 C
ATOM 2314 O VAL 426 11.258 83.671 21.790 1.00 49.82 O
ATOM 2315 N THR 427 11.803 82.591 19.897 1.00 49.57 N
ATOM 2316 CA THR 427 10.785 83.258 19.098 1.00 50.57 C
ATOM 2317 CB THR 427 11.188 83.295 17.614 1.00 50.78 C
ATOM 2318 OGl THR 427 11.232 81.960 17.094 1.00 50.79 O
ATOM 2319 CG2 THR 427 12.552 83.934 17.456 1.00 50.62 C
ATOM 2320 C THR 427 9.416 82.596 19.205 1.00 50.96 C
ATOM 2321 O THR 427 8.441 83.095 18.645 1.00 51.85 O
ATOM 2322 N SER 428 9.336 81.469 19.906 1.00 50.79 N
ATOM 2323 CA SER 428 8.054 80.792 20.048 1.00 50.98 C
ATOM 2324 CB SER 428 7.670 80.078 18.746 1.00 52.05 C
ATOM 2325 OG SER 428 8.449 78.911 18.532 1.00 52.37 O
ATOM 2326 C SER 428 7.982 79.797 21.197 1.00 51.26 C
ATOM 2327 O SER 428 8.954 79.557 21.912 1.00 51.62 O
ATOM 2328 N GLU 429 6.801 79.214 21.340 1.00 51.39 N
ATOM 2329 CA GLU 429 6.493 78.246 22.379 1.00 51.44 C
ATOM 2330 CB GLU 429 4.967 78.140 22.480 1.00 53.37 C
ATOM 2331 CG GLU 429 4.420 77.241 23.566 1.00 55.58 C
ATOM 2332 CD GLU 429 2.925 77.453 23.772 1.00 56.81 C
ATOM 2333 OEl GLU 429 2.538 78.571 24.183 1.00 58.58 O
ATOM 2334 OE2 GLU 429 2.140 76.514 23.521 1.00 56.74 O ATOM 2335 C GLU 429 7.112 76.867 22.133 1.00 49.74 C
ATOM 2336 O GLU 429 7.208 76.054 23.051 1.00 49.81 O
ATOM 2337 N THR 430 7.548 76.611 20.905 1.00 47.49 N
ATOM 2338 CA THR 430 8.124 75.312 20.564 1.00 46.28 C
ATOM 2339 CB THR 430 7.229 74.591 19.549 1.00 46.07 C
ATOM 2340 OGl THR 430 7.053 75.430 18.400 1.00 46.81 O
ATOM 2341 CG2 THR 430 5.869 74.289 20.158 1.00 46.10 C
ATOM 2342 C THR 430 9.528 75.394 19.980 1.00 44.69 C
ATOM 2343 O THR 430 10.111 74.384 19.606 1.00 45.21 O
ATOM 2344 N ASP 431 10.056 76.607 19.923 1.00 43.35 N
ATOM 2345 CA ASP 431 11.371 76.917 19.367 1.00 42.77 C
ATOM 2346 CB ASP 431 11.844 78.216 20.014 1.00 42.78 C
ATOM 2347 CG ASP 431 13.044 78.807 19.328 1.00 41.70 C
ATOM 2348 ODl ASP 431 13.173 80.050 19.340 1.00 41.44 O
ATOM 2349 OD2 ASP 431 13.861 78.034 18.790 1.00 42.43 O
ATOM 2350 C ASP 431 12.524 75.881 19.328 1.00 42.48 C
ATOM 2351 O ASP 431 13.185 75.748 18.299 1.00 46.09 O
ATOM 2352 N THR 432 12.782 75.164 20.416 1.00 41.04 N
ATOM 2353 CA THR 432 13.870 74.163 20.467 1.00 38.51 C
ATOM 2354 CB THR 432 13.643 72.951 19.494 1.00 38.70 C
ATOM 2355 OGl THR 432 13.934 73.331 18.140 1.00 37.36 O
ATOM 2356 CG2 THR 432 12.221 72.454 19.588 1.00 36.44 C
ATOM 2357 C THR 432 15.285 74,692 20.207 1.00 36.89 C
ATOM 2358 O THR 432 16.251 73.931 20.244 1.00 34.45 O
ATOM 2359 N ARG 433 15.411 75.991 19.957 1.00 36.51 N
ATOM 2360 CA ARG 433 16.714 76.603 19.700 1.00 37.78 C
ATOM 2361 CB ARG 433 16.606 78.123 19.807 1.00 39.71 C
ATOM 2362 CG ARG 433 17.928 78.842 19.595 1.00 43.42 C
ATOM 2363 CD ARG 433 17.830 80.295 20.035 1.00 46.55 C
ATOM 2364 NE ARG 433 16.556 80.903 19.654 1.00 49.19 N
ATOM 2365 CZ ARG 433 16.173 81.148 18.404 1.00 49.75 C
ATOM 2366 NHl ARG 433 16.965 80.840 17.386 1.00 50.56 N
ATOM 2367 NH2 ARG 433 14.991 81.705 18.174 1.00 50.33 N
ATOM 2368 C ARG 433 17.816 76.139 20.659 1.00 36.77 C
ATOM 2369 O ARG 433 18.907 75.756 20.239 1.00 35.91 O
ATOM 2370 N TYR 434 17.529 76.183 21.955 1.00 36.02 N
ATOM 2371 CA TYR 434 18.516 75.794 22.948 1.00 37.09 C
ATOM 2372 CB TYR 434 18.074 76.318 24.323 1.00 35.23 C
ATOM 2373 CG TYR 434 18.132 77.835 24.383 1.00 34.55 C
ATOM 2374 CDl TYR 434 19.354 78.495 24.461 1.00 34.18 C
ATOM 2375 CEl TYR 434 19.433 79.869 24.419 1.00 32.71 C
ATOM 2376 CD2 TYR 434 16.979 78.607 24.271 1.00 33.95 C
ATOM 2377 CE2 TYR 434 17.048 80.000 24.227 1.00 35.24 C
ATOM 2378 CZ TYR 434 18.286 80.619 24.299 1.00 35.74 C
ATOM 2379 OH TYR 434 18.386 81.993 24.233 1.00 38.50 O
ATOM 2380 C TYR 434 18.854 74.303 22.972 1.00 37.61 C
ATOM 2381 O TYR 434 19.946 73.922 23.388 1.00 39.14 O
ATOM 2382 N PHE 435 17.939 73.457 22.507 1.00 38.93 N
ATOM 2383 CA PHE 435 18.211 72.024 22.467 1.00 39.92 C
ATOM 2384 CB PHE 435 16.918 71.215 22.317 1.00 40.39 C
ATOM 2385 CG PHE 435 15.991 71.326 23.482 1.00 39.85 C
ATOM 2386 CDl PHE 435 15.043 72.330 23.537 1.00 40.33 C
ATOM 2387 CD2 PHE 435 16.069 70.422 24.529 1.00 39.88 C
ATOM 2388 CEl PHE 435 14.190 72.430 24.614 1.00 41.04 C
ATOM 2389 CE2 PHE 435 15.220 70.518 25.609 1.00 39.03 C
ATOM 2390 CZ PHE 435 14.279 71.522 25.651 1.00 39.79 C
ATOM 2391 C PHE 435 19.114 71.704 21.275 1.00 42.36 C
ATOM 2392 O PHE 435 19.937 70.790 21.331 1.00 41.12 O
ATOM 2393 N ASP 436 18.941 72.457 20.193 1.00 44.29 N
ATOM 2394 CA ASP 436 19.722 72.241 18.987 1.00 48.34 C
ATOM 2395 CB ASP 436 19.060 72.940 17.797 1.00 47.65 C
ATOM 2396 CG ASP 436 17.598 72.563 17.642 1.00 47.53 C
ATOM 2397 ODl ASP 436 17.270 71.373 17.822 1.00 48.55 O
ATOM 2398 OD2 ASP 436 16.777 73.451 17.336 1.00 48.28 O
ATOM 2399 C ASP 436 21.154 72.726 19.151 1.00 51.44 C
ATOM 2400 O ASP 436 22.096 72.019 18.788 1.00 51.49 O
ATOM 2401 N GLU 437 21.316 73.931 19.694 1.00 55.79 N
ATOM 2402 CA GLU 437 22.646 74.498 19.912 1.00 59.86 C
ATOM 2403 CB GLU 437 22.547 75.906 20.504 1.00 60.39 C
ATOM 2404 CG GLU 437 21.783 76.906 19.661 1.00 62.62 C
ATOM 2405 CD GLU 437 21.709 78.268 20.323 1.00 64.02 C
ATOM 2406 OEl GLU 437 21.032 79.169 19.778 1.00 64.68 O
ATOM 2407 OE2 GLU 437 22.333 78.437 21.394 1.00 64.65 O ATOM 2408 C GLU 437 23.406 73.608 20.881 1.00 62.18 C
ATOM 2409 O GLU 437 23.483 73.898 22.073 1.00 63.26 O
ATOM 2410 N GLU 438 23.967 72.523 20.365 1.00 65.58 N
ATOM 2411 CA GLU 438 24.710 71.582 21.188 1.00 68.13 C
ATOM 2412 CB GLU 438 23.843 70.361 21.505 1.00 68.37 C
ATOM 2413 CG GLU 438 22.694 70.638 22.447 1.00 69.14 C
ATOM 2414 CD GLU 438 23.164 70.959 23.851 1.00 69.40 C
ATOM 2415 OEl GLU 438 23.947 •70.162 24.410 1.00 70.38 O
ATOM 2416 OE2 GLU 438 22.747 72.001 24.397 1.00 69.15 O
ATOM 2417 C GLU 438 25.975 71.122 20.482 1.00 69.90 C
ATOM 2418 O GLU 438 27.075 71.587 20.789 1.00 70.09 O
ATOM 2419 N PHE 439 25.804 70.204 19.534 1.00 71.14 N
ATOM 2420 CA PHE 439 26.925 69.650 18.786 1.00 72.29 C
ATOM 2421 CB PHE 439 27.736 70.776 18.131 1.00 72.81 C
ATOM 2422 CG PHE 439 28.189 70.465 16.730 1.00 73.36 C
ATOM 2423 CDl PHE 439 28.948 71.378 16.014 1.00 73.80 C
ATOM 2424 CD2 PHE 439 27.844 69.266 16.124 1.00 73.79 C
ATOM 2425 CEl PHE 439 29.354 71.103 14.718 1.00 73.74 C
ATOM 2426 CE2 PHE 439 28.246 68.983 14.830 1.00 74.31 C
ATOM 2427 CZ PHE 439 29.003 69.904 14.126 1.00 74.31 C
ATOM 2428 C PHE 439 27.785 68.885 19.791 1.00 72.52 C
ATOM 2429 O PHE 439 28.908 68.474 19.490 1.00 73.28 O
ATOM 2430 OH2 TIP 1 17.424 87.524 53.963 1.00 22.46 S O
ATOM 2431 OH2 TIP 2 14.680 88.222 52.362 1.00 19.08 S O
ATOM 2432 OH2 TIP 3 19.099 67.297 46.379 1.00 28.70 S O
ATOM 2433 OH2 TIP 4 7.221 77.476 48.141 1.00 27.90 S O
ATOM 2434 OH2 TIP 5 18.107 66.748 57.540 1.00 33.19 S O
ATOM 2435 OH2 TIP 6 10.192 80.973 62.808 1.00 27.18 S O
ATOM 2436 OH2 TIP 7 12.655 91.335 46.083 1.00 22.52 S O
ATOM 2437 OH2 TIP 8 17.180 83.703 33.650 1.00 29.23 S O
ATOM 2438 OH2 TIP 9 32.542 71.745 53.014 1.00 32.12 S O
ATOM 2439 OH2 TIP 10 19.328 89.982 48.358 1.00 26.21 S O
ATOM 2440 OH2 TIP 11 4.137 92.031 44.382 1.00 27.96 S O
ATOM 2441 OH2 TIP 12 24.068 90.263 50.084 1.00 31.60 S O
ATOM 2442 OH2 TIP 13 15.105 76.178 22.812 1.00 31.02 S O
ATOM 2443 OH2 TIP 14 4.784 71.599 39.411 1.00 31.96 S O.
ATOM 2444 0H2 TIP 15 19.805 82.205 59.000 1.00 28.52 S O
ATOM 2445 OH2 TIP 16 26.037 90.490 41.063 1.00 30.35 S O
ATOM 2446 OH2 TIP 17 7.364 81.829 33.410 1.00 36.14 S O
ATOM 2447 OH2 TIP 18 11.343 83.855 58.817 1.00 41.24 S O
ATOM 2448 OH2 TIP 19 9.527 88.171 51.971 1.00 27.84 S O
ATOM 2449 OH2 TIP 20 15.667 76.567 62.105 1.00 32.29 S O
ATOM 2450 OH2 TIP 21 29.059 66.788 47.201 1.00 31.05 S O
ATOM 2451 OH2 TIP 22 25.733 89.708 46.109 1.00 32.69 S O
ATOM 2452 OH2 TIP 23 30.152 85.207 40.474 1.00 31.14 S O
ATOM 2453 OH2 TIP 24 2.894 75.539 45.368 1.00 35.34 S O
ATOM 2454 OH2 TIP 25 25.794 86.656 34.948 1.00 33.62 S O
ATOM 2455 OH2 TIP 26 10.383 74.176 54.771 1.00 35.08 S O
ATOM 2456 OH2 TIP 27 32.134 71.847 58.205 1.00 43.20 S O
ATOM 2457 OH2 TIP 28 23.002 86.046 57.702 1.00 26.95 S O
ATOM 2458 OH2 TIP 29 30.233 70.278 60.355 1.00 32.22 S O
ATOM 2459 OH2 TIP 30 31.563 75.102 55.479 1.00 31.41 S O
ATOM 2460 OH2 TIP , 31 10.255 85.019 40.920 1.00 39.31 S O
ATOM 2461 OH2 TIP 32 31.723 68.864 44.382 1.00 37.22 S O
ATOM 2462 OH2 TIP 33 20.782 64.952 55.807 1.00 36.92 S O
ATOM 2463 OH2 TIP 34 14.241 64.944 56.900 1.00 40.47 S O
ATOM 2464 OH2 TIP 35 21.617 66.821 47.313 1.00 41.74 S O
ATOM 2465 OH2 TIP 36 9.444 75.991 58.354 1.00 45.70 S O
ATOM 2466 OH2 TIP 37 18.576 91.473 46.351 1.00 40.43 S O
ATOM 2467 OH2 TIP 38 3.255 71.047 13.655 1.00 33.97 S O
ATOM 2468 OH2 TIP 39 17.658 55.459 28.854 1.00 45.27 S O
ATOM 2469 OH2 TIP 40 37.069 74.463 46.749 1.00 39.93 S O
ATOM 2470 OH2 TIP 41 29.031 89.262 40.895 1.00 37.26 S O
ATOM 2471 OH2 TIP 42 12.587 61.800 46.772 1.00 39.08 S O
ATOM 2472 OH2 TIP 43 14.998 91.103 44.598 1.00 35.88 S O
ATOM 2473 OH2 TIP 44 13.348 62.949 43.331 1.00 44.78 S O
ATOM 2474 OH2 TIP 45 33.825 73.564 54.384 1.00 47.17 S O
ATOM 2475 OH2 TIP 46 10.602 67.878 56.115 1.00 37.78 S O
ATOM 2476 OH2 TIP 47 26.510 90.535 48.814 1.00 36.15 S O
ATOM 2477 OH2 TIP 48 3.230 81.477 40.543 1.00 39.74 S O
ATOM 2478 OH2 TIP 49 24.444 77.131 59.910 1.00 35.82 S O
ATOM 2479 OH2 TIP 50 3.840 90.079 48.282 1.00 43.72 S O
ATOM 2480 OH2 TIP 51 9.063 81.372 47.853 1.00 33.84 S O ATOM 2481 OH2 TIP 52 19.060 62.514 38.644 00 46.21 S O
ATOM 2482 OH2 TIP 53 18.909 88.893 28.897 00 41.59 S .0
ATOM 2483 OH2 TIP 54 23.920 90.251 36.638 00 39.51 S O
ATOM 2484 OH2 TIP 55 10.328 91.763 44.379 00 45.14 S O
ATOM 2485 OH2 TIP 56 8.658 76.239 15.799 00 38.42 S O
ATOM 2486 OH2 TIP 57 -4.923 73.991 44.228 00 44.35 S O
ATOM 2487 OH2 TIP 58 38.397 70.024 44.686 00 47.44 S O
ATOM 2488 OH2 TIP 59 18.870 68.633 59.701 00 46.22 S O
ATOM 2489 OH2 TIP 60 8.979 89.478 35.460 00 49.93 S O
ATOM 2490 OH2 TIP 61 17.048 91.171 37.144 00 40.50 S O
ATOM 2491 OH2 TIP 62 9.799 55.271 20.036 00 53.25 S o_
ATOM 2492 OH2 TIP 63 28.438 69.087 36.833 ,00 50.99 S o~
ATOM 2493 OH2 TIP 64 31.191 81.629 57.203 00 47.33 S O
ATOM 2494 OH2 TIP 65 6.953 87.968 51.287 ,00 35.85 S O
ATOM 2495 OH2 TIP 66 11.481 87.501 30.963 ,00 33.68 S O
ATOM 2496 OH2 TIP 67 5.602 69.062 39.907 ,00 36.92 S O
ATOM 2497 OH2 TIP 68 27.417 93.291 38.626 ,00 51.81 S O
ATOM 2498 OH2 TIP 69 4.593 53.813 18.310 .00 45.29 S O
ATOM 2499 OH2 TIP 70 2.296 67.886 38.079 ,00 48.48 S O
ATOM 2500 OH2 TIP 71 9.474 77.319 28.350 ,00 35.53 S O
ATOM 25011 OH2 TIP 72 10.875 61.844 50.122 ,00 39.07 S O
ATOM 2502 OH2 TIP 73 13.467 86.841 54.998 .00 39.83 S O
ATOM 2503 OH2 TIP 74 15.565 58.632 17.507 ,00 49.91 S O
ATOM 2504 OH2 TIP 75 31.700 58.481 19.947 ,00 63.24 S O
ATOM 2505 OH2 TIP 76 33.914 86.497 42.415 1.00 43.25 S O
ATOM 2506 OH2 TIP 77 1.176 73.721 25.207 00 52.60 S O
ATOM 2507 OH2 TIP 78 11.635 71.238 59.472 ,00 46.37 S O
ATOM 2508 OH2 TIP 79 0.603 70.563 46.630 00 41.40 S O
ATOM 2509 OH2 TIP 80 31.652 88.141 42.752 ,00 39.75 S O
ATOM 2510 OH2 TIP 81 1.184 72.859 27.592 ,00 47.67 S O
ATOM 2511 OH2 TIP 82 3.616 61.517 15.187 ,00 45.57 S O
ATOM 2512 OH2 TIP 83 12.044 85.173 55.720 ,00 52.38 S O
ATOM 2513 OH2 TIP 84 44.717 84.237 34.252 ,00 64.89 S O
ATOM 2514 OH2 TIP 85 21.895 91.180 49.768 00 48.24 S O
ATOM 2515 OH2 TIP 86 42.161 64.286 49.151 .00 47.76 S O
ATOM 2516 OH2 TIP 87 10.790 92.168 41.555 00 45.76 S O
ATOM 2517 OH2 TIP 88 22.973 60.572 18.655 ,00 48.90 S O
ATOM 2518 OH2 TIP 89 5.879 74.239 36.714 ,00 46.28 S O
ATOM 2519 OH2 TIP 90 17.041 89.384 55.999 ,00 45.92 S O
ATOM 2520 OH2 TIP 91 28.447 80.141 57.228 ,00 45.11 S O
ATOM 2521 OH2 TIP 92 3.218 67.792 48.689 ,00 51.90 S O
ATOM 2522 OH2 TIP 93 -4.405 62.349 22.385 ,00 43.42 S O
ATOM 2523 OH2 TIP 94 44.583 88.230 47.358 00 44.29 S O
ATOM 2524 0H2 TIP 95 24.770 67.963 65.759 ,00 43.27 S O
ATOM 2525 OH2 TIP 96 13.821 91.658 40.576 00 45.15 S O
ATOM 2526 OH2 TIP 97 21.055 71.918 32.968 1.00 40.93 S O
ATOM 2527 OH2 TIP 98 20.068 46.072 33.253 00 60.84 S O
ATOM 2528 OH2 TIP 99 38.903 80.867 50.848 00 46.16 S O
ATOM 2529 OH2 TIP 100 22.764 91.988 53.345 00 41.48 S O
ATOM 2530 OH2 TIP 101 28.002 69.731 68.857 00 54.09 S O
ATOM 2531 OH2 TIP 102 32.681 82.617 55.107 00 51.63 S O
ATOM 2532 OH2 TIP 103 33.904 84.429 40.631 00 44.07 .S O
ATOM 2533 OH2 TIP 104 21.314 91.102 37.784 00 46.41 S O
ATOM 2534 OH2 TIP 105 1.053 82.030 47.883 00 52.13 S O
ATOM 2535 OH2 TIP 106 4.899 76.721 49.531 00 60.73 S O
ATOM 2536 OH2 TIP 107 34.851 68.209 36.568 00 49.21 S O
ATOM 2537 OH2 TIP 108 12.331 91.040 22.157 00 51.96 S O
ATOM 2538 OH2 TIP 109 3.066 63.504 50.254 00 59.03 S O
ATOM 2539 OH2 TIP 110 23.134 70.925 27.016 00 53.11 S O
ATOM 2540 OH2 TIP 111 21.778 58.743 38.157 00 53.22 S O
ATOM 2541 OH2 TIP 112 18.456 86.048 61.315 00 55.92 S O
ATOM 2542 OH2 TIP 113 18.863 95.998 38.958 00 57.07 S O
ATOM 2543 OH2 TIP 114 9.189 78.271 35.779 00 41.76 S O
ATOM 2544 OH2 TIP 115 3.799 88.688 45.257 00 36.69 S O
ATOM 2545 OH2 TIP 116 38.093 70.779 48.035 00 52.09 S O
ATOM 2546 OH2 TIP 117 22.010 78.102 60.880 00 60.11 S O
ATOM 2547 OH2 TIP 118 35.244 53.504 45.681 00 50.73 S O
ATOM 2548 OH2 TIP 119 24.653 81.924 59.072 00 43.77 S O
ATOM 2549 OH2 TIP 120 34.869 82.472 54.580 00 50.71 S O
ATOM 2550 OH2 TIP 121 12.919 87.206 19.934 00 61.62 S O
ATOM 2551 OH2 TIP 122 39.657 91.755 41.079 00 36.28 S O
ATOM 2552 OH2 TIP 123 7.982 79.847 49.477 00 43.38 S O
ATOM 2553 OH2 TIP 124 33.777 87.357 35.938 1.00 55.12 S O ATOM 2554 OH2 TIP 125 -2.126 79.410 38.678 49.58 S O
ATOM 2555 OH2 TIP 126 34.435 87.019 54.224 42.07 S O
ATOM 2556 OH2 TIP 127 40.006 84.089 35.486 56.34 S O
ATOM 2557 OH2 TIP 128 35.922 68.404 58.284 55.27 S O
ATOM 2558 OH2 TIP 129 31.888 85.675 55.057 35.21 S O
ATOM 2559 OH2 TIP 130 33.207 48.136 38.512 53.23 S O
ATOM 2560 OH2 TIP 131 9.681 50.843 17.747 51.67 S O
ATOM 2561 OH2 TIP 132 23.514 63.820 48.334 50.79 S O
ATOM 2562 OH2 TIP 133 23.101 55.516 35.412 54.00 S O
ATOM 2563 OH2 TIP 134 7.230 78.158 32.663 39.27 S O
ATOM 2564 OH2 TIP 135 35.554 73.886 35.711 51.57 S O
ATOM 2565 OH2 TIP 136 26.755 89.921 31.100 54.86 S O
ATOM 2566 OH2 TIP 137 29.011 82.825 58.108 42.58 S O
ATOM 2567 OH2 TIP 138 37.726 68.243 18.947 50.61 S O
ATOM 2568 OH2 TIP 139 26.813 86.768 56.443 56.20 S O
ATOM 2569 OH2 TIP 140 29.128 73.586 34.310 63.04 S O
ATOM 2570 OH2 TIP 141 17.787 68.985 18.936 59.38 S O
ATOM 2571 OH2 TIP 142 38.645 88.220 52.082 65.86 S O
ATOM 2572 OH2 TIP 143 6.293 83.051 57.843 44.93 S O
ATOM 2573 OH2 TIP 144 27.967 63.997 26.960 52.53 S O
ATOM 2574 OH2 TIP 145 17.243 55.490 22.179 46.19 S O
ATOM 2575 OH2 TIP 146 31.578 74.206 59.087 48.30 S O
ATOM 2576 OH2 TIP 147 21.246 64.011 21.281 45.73 S O
ATOM 2577 OH2 TIP 148 -6.610 60.968 20.489 57.51 S O
ATOM 2578 OH2 TIP 149 21.942 82.632 24.301 47.99 S O
ATOM 2579 OH2 TIP 150 -1.595 53.189 12.577 51.22 S O
ATOM 2580 OH2 TIP 151 38.601 88.536 36.475 50.98 S O
ATOM 2581 OH2 TIP 152 7.784 86.268 34.197 51.99 S O
ATOM 2582 OH2 TIP 153 15.224 78.505 16.128 43.71 S O
ATOM 2583 OH2 TIP 154 40.943 72.379 54.409 48.98 S O
ATOM 2584 OH2 TIP 155 -1.014 60.813 40.326 55.37 S O
ATOM 2585 OH2 TIP 156 7.633 91.565 38.224 40.82 S O
ATOM 2586 OH2 TIP 157 41.126 68.327 38.380 1.00 68.60 S O
ATOM 2587 OH2 TIP 158 29.595 74.972 62.064 55.94 S O
ATOM 2588 OH2 TIP 159 2.601 69.878 50.180 66.10 S O
ATOM 2589 OH2 TIP 160 13.364 67.826 30.482 59.53 S O
ATOM 2590 OH2 TIP 161 0.416 66.001 37.707 67.75 S O
ATOM 2591 OH2 TIP 162 42.850 80.984 35.087 54.18 S O
ATOM 2592 OH2 TIP 163 19.917 68.349 25.195 54.21 S O
ATOM 2593 OH2 TIP 164 25.241 78.948 21.936 65.01 S O
ATOM 2594 OH2 TIP 165 12.951 67.020 59.472 48.35 S O
ATOM 2595 OH2 TIP 166 1.893 62.423 14.304 55.44 S O
ATOM 2596 OH2 TIP 167 21.309 50.548 45.676 46.38 S O
ATOM 2597 OH2 TIP 168 32.646 65.024 58.135 51.98 S O
ATOM 2598 OH2 TIP 169 18.221 47.020 39.286 52.53 S O
ATOM 2599 OH2 TIP 170 16.837 66.308 33.921 43.79 S O
ATOM 2600 OH2 TIP 171 37.584 59.216 28.497 64.41 S O
ATOM 2601 OH2 TIP 172 5.384 43.880 20.389 57.84 S O
ATOM 2602 OH2 TIP 173 20.342 76.174 15.914 56.05 S O
ATOM 2603 OH2 TIP 174 9.954 57.910 13.865 67.43 S O
ATOM 2604 OH2 TIP 175 26.881 71.339 23.425 1.00 59.89 S O
ATOM 2605- OH2 TIP 176 30.673 65.694 14.282 61.58 S O
ATOM 2606 OH2 TIP 177 34.659 71.536 38.207 46.67 S O
ATOM 2607 OH2 TIP 178 -1.735 58.381 30.892 47.66 S O
ATOM 2608 OH2 TIP 179 21.931 48.314 28.854 52.60 S O
ATOM 2609 OH2 TIP 180 31.913 68.208 61.399 54.80 S O
ATOM 2610 OH2 TIP 181 16.103 52.889 43.048 60.96 S O
ATOM 2611 OH2 TIP 182 39.722 81.441 38.215 70.08 S O
ATOM 2612 OH2 TIP 183 10.806 70.877 57.370 41.17 S O
ATOM 2613 OH2 TIP 184 13.569 89.764 31.474 53.03 S O
ATOM 2614 OH2 TIP 185 27.502 65.374 34.076 49.02 S O
ATOM 2615 OH2 TIP 186 12.297 68.722 60.863 54.15 S O
ATOM 2616 OH2 TIP 187 44.356 83.081 37.071 62.55 S O
ATOM 2617 OH2 TIP 188 24.017 95.423 37.224 58.70 S O
ATOM 2618 OH2 TIP 189 4.722 81.785 50.529 72.11 S O
ATOM 2619 OH2 TIP 190 3.082 73.841 35.447 68.90 S O
ATOM 2620 OH2 TIP 191 32.139 62.978 28.056 55.00 S O
ATOM 2621 OH2 TIP 192 22.362 83.617 59.002 46.63 S O
ATOM 2622 OH2 TIP 193 28.584 88.768 55.713 47.61 S O
ATOM 2623 OH2 TIP 194 26.419 90.809 55.993 44.01 S O
ATOM 2624 OH2 TIP 195 10.955 77.144 15.485 58.05 S O
ATOM 2625 OH2 TIP 196 45.029 76.202 50.873 66.75 S O
ATOM 2626 OH2 TIP 197 23.717 62.300 60.169 1.00 50.32 S O ATOM 2627 OH2 TIP 198 -0.542 53.261 19.923 1.00 51.41 S O
ATOM 2628 OH2 TIP 199 -0.863 79.253 35.872 1.00 58.15 S O
ATOM 2629 OH2 TIP 200 45.666 69.871 52.040 1.00 56.55 S O
ATOM 2630 OH2 TIP 201 25.697 56.638 35.922 1.00 69.16 S O
ATOM 2631 OH2 TIP 202 37.641 71.221 39.003 1.00 55.73 S O
ATOM 2632 OH2 TIP 203 4.349 72.075 28.318 1.00 51.56 S O
ATOM 2633 OH2 TIP 204 27.231 78.793 23.050 1.00 60.46 S O
ATOM 2634 OH2 TIP 205 18.219 88.671 41.891 1.00 45.64 S O
ATOM 2635 OH2 TIP 206 20.173 54.688 37.723 1.00 57.23 S O
ATOM 2636 OH2 TIP 207 36.411 61.551 23.395 1.00 67.22 S O
ATOM 2637 OH2 TIP 208 -5.134 57.694 18.222 1.00 68.96 S O
ATOM 2638 OH2 TIP 209 7.754 58.744 13.088 1.00 71.57 S O
ATOM 2639 OH2 TIP 210 15.629 90.427 41.610 1.00 44.49 S O
ATOM 2640 OH2 TIP 211 36.965 79.528 37.206 1.00 66.56 S O
ATOM 2641 OH2 TIP 212 48.352 82.476 35.505 1.00 59.47 S O
ATOM 2642 OH2 TIP 213 -2.810 67.011 16.298 1.00 48.95 S O
ATOM 2643 OH2 TIP 214 1.976 79.998 48.417 1.00 62.99 S O
ATOM 2644 OH2 TIP 215 44.351 65.632 50.766 1.00 59.46 S O
ATOM 2645 OH2 TIP 216 -3.626 54.286 11.734 1.00 57.20 S O
ATOM 2646 OH2 TIP 217 36.322 81.542 57.389 1.00 60.96 S O
ATOM 2647 OH2 TIP 218 37.008 82.367 32.079 1.00 56.29 S O
ATOM 2648 OH2 TIP 219 6.582 76.439 54.079 1.00 49.83 S O
ATOM 2649 OH2 TIP 220 31.806 84.970 60.283 1.00 56.28 S O
ATOM 2650 OH2 TIP 221 24.370 48.576 25.818 1.00 54.93 S O
ATOM 2651 OH2 TIP 222 24.539 60.194 27.524 1.00 52.95 S O
ATOM 2652 OH2 TIP 223 3.408 78.882 33.992 1.00 50.45 S O
ATOM 2653 OH2 TIP 224 19.493 85.310 19.251 1.00 50.68 S O
ATOM 2654 OH2 TIP 225 43.428 82.199 33.034 1.00 69.94 S O
ATOM 2655 OH2 TIP 226 24.893 55.455 26.518 1.00 60.10 S O
ATOM 2656 OH2 TIP 227 23.135 66.812 19.760 1.00 52.93 S O
ATOM 2657 OH2 TIP 228 0.587 75.849 18.573 1.00 58.43 S O
ATOM 2658 OH2 TIP 229 5.426 78.696 58.367 1.00 55.62 S O
ATOM 2659 OH2 TIP 230 48.130 80.776 32.572 1.00 58.05 S O
ATOM 2660 OH2 TIP 231 -0.915 57.061 37.264 1.00 63.27 S O
ATOM 2661 OH2 TIP 232 41.055 80.409 43.862 1.00 56.74 S O
ATOM 2662 OH2 TIP 233 -3.773 55.824 16.448 1.00 52.52 S O
ATOM 2663 OH2 TIP 234 34.607 62.540 59.908 1.00 62.60 S O
ATOM 2664 OH2 TIP 235 34.660 71.743 29.157 1.00 55.49 S O
ATOM 2665 OH2 TIP 236 38.787 66.210 19.600 1.00 56.09 S O
ATOM 2666 OH2 TIP 237 5.330 59.653 20.079 1.00 60.65 S O
ATOM 2667 OH2 TIP 238 33.156 62.306 36.469 1.00 61.53 S O
ATOM 2668 OH2 TIP 239 1.087 82.819 41.638 1.00 49.11 S O
ATOM 2669 OH2 TIP 240 0.125 52.505 28.008 1.00 54.61 S O
ATOM 2670 OH2 TIP 241 10.361 86.723 54.211 1.00 47.21 S O
ATOM 2671 OH2 TIP 242 33.082 72.854 33.130 1.00 51.81 S O
ATOM 2672 OH2 TIP 243 33.897 83.526 28.222 1.00 52.43 S O
ATOM 2673 OH2 TIP 244 39.882 86.259 39.188 1.00 53.68 S O
ATOM 2674 OH2 TIP 245 31.905 76.911 34.375 1.00 45.71 S O
ATOM 2675 OH2 TIP 246 25.636 72.295 12.644 1.00 58.14 S O
ATOM 2676 OH2 TIP 247 14.550 41.001 24.366 1.00 72.37 S O
ATOM 2677 OH2 TIP 248 -0.112 86.924 45.509 1.00 55.37 S O
ATOM 2678 OH2 TIP 249 -3.844 71.029 17.777 1.00 49.43 S O
ATOM 2679 OH2 TIP 250 7.608 76.354 26.373 1.00 49.30 S O
ATOM 2680 OH2 TIP 251 49.277 84.454 34.289 1.00 55.35 S O
ATOM 2681 OH2 TIP 252 33.077 70.407 19.230 1.00 53.42 S O
ATOM 2682 OH2 TIP 253 27.620 64.356 12.347 1.00 46.51 S O
ATOM 2683 OH2 TIP 254 13.941 94.334 38.833 1.00 68.79 S O
ATOM 2684 OH2 TIP 255 2.081 78.539 40.352 1.00 47.56 S O
ATOM 2685 OH2 TIP 256 40.909 68.742 44.270 1.00 56.66 S O
ATOM 2686 OH2 TIP 257 -6.591 73.802 25.122 1.00 65.77 S O
ATOM 2687 OH2 TIP 258 -5.157 64.112 15.502 1.00 51.25 S O
ATOM 2688 OH2 TIP 259 19.450 65.043 28.269 1.00 65.48 S O
ATOM 2689 OH2 TIP 260 7.232 82.922 23.760 1.00 48.06 S O
ATOM 2690 OH2 TIP 261 -5.656 74.434 47.490 1.00 56.73 S O
ATOM 2691 OH2 TIP 262 40.974 76.775 52.738 1.00 72.35 S O
ATOM 2692 OH2 TIP 263 37.073 84.213 39.886 1.00 60.00 S O
ATOM 2693 OH2 TIP 264 1.543 47.180 25.456 1.00 56.85 S O
ATOM 2694 OH2 TIP 265 -4.177 54.837 21.753 1.00 53.75 S O
ATOM 2695 OH2 TIP 266 46.547 78.250 32.383 1.00 65.74 S O
ATOM 2696 OH2 TIP 267 22.349 64.284 43.575 1.00 69.31 S O
ATOM 2697 OH2 TIP 268 27.628 91.558 35.794 1.00 50.74 S O
ATOM 2698 OH2 TIP 269 5.645 86.330 35.491 1.00 55.59 S O
ATOM 2699 OH2 TIP 270 5.294 86.654 52.716 1.00 49.39 S O ATOM 2700 OH2 TIP 271 35.890 82.802 35.341 1.00 61.91 O
ATOM 2701 OH2 TIP 272 33.892 63 .669 32 .090 1.00 56.35 O
ATOM 2702 OH2 TIP 273 18.910 60 .460 15 .692 1.00 58.83 O
ATOM 2703 OH2 TIP 274 25.582 91 .845 38 .053 1.00 63.46 O
ATOM 2704 OH2 TIP 275 12.100 39 .340 22 .960 1.00 60.01 O
ATOM 2705 OH2 TIP 276 5.323 44 .278 34 .428 1.00 55.64 O
ATOM 2706 OH2 TIP 277 32.973 81 .283 61 .147 1.00 59.51 O
END
Table 3. Atomic Coordinates of Akt3 complexed to N-[6-(aminomethyl)-4- chloro-l,3-benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene-2- carboxamide.
REMARK PROGRAM REFMAC 5.1.24 REMARK AUTHORS MURSHUDOV,VAGIN,DODSON REMARK REMARK REFINEMENT TARGET : MAXIMUM LIKELIHOOD REMARK REMARK DATA USED IN REFINEMENT. REMARK RESOLUTION RANGE HIGH (ANGSTROMS) : 2.40 REMARK RESOLUTION RANGE LOW (ANGSTROMS) : 57.74 REMARK DATA CUTOFF (SIGMA(F)) : NONE REMARK COMPLETENESS FOR RANGE (%) : 97.71 REMARK NUMBER OF REFLECTIONS : 12815 REMARK 'REMARK FIT TO DATA USED IN REFINEMENT. REMARK CROSS-VALIDATION METHOD THROUGHOUT REMARK FREE R VALUE TEST SET SELECTION RANDOM REMARK R VALUE (WORKING + TEST SET) 0.23722 REMARK R VALUE (WORKING SET) 0.23431 REMARK FREE R VALUE 0.29248 REMARK FREE R VALUE TEST SET SIZE (%) 5.0 REMARK FREE R VALUE TEST SET COUNT 671 REMARK REMARK FIT IN THE HIGHEST RESOLUTION BIN. REMARK TOTAL NUMBER OF BINS USED 20 REMARK BIN RESOLUTION RANGE HIGH 2.397 REMARK BIN RESOLUTION RANGE LOW 2.459 REMARK REFLECTION IN BIN (WORKING SET) 882 REMARK BIN R VALUE (WORKING SET) 0.265 REMARK BIN FREE R VALUE SET COUNT 43 REMARK BIN FREE R VALUE 0.414 REMARK REMARK NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK ALL ATOMS : 2539 REMARK REMARK B VALUES. REMARK FROM WILSON PLOT (A**2) NULL REMARK MEAN B VALUE (OVERALL, A**2) 29.021 REMARK OVERALL ANISOTROPIC B VALUE. REMARK BIl (A**2) 2, 64 REMARK B22 (A**2) -0 97 REMARK B33 (A**2) -1 67 REMARK B12 (A**2) 0, 00 REMARK B13 (A**2) 0, 00 REMARK B23 (A**2) 0 00 REMARK REMARK ESTIMATED OVERALL COORDINATE ERROR. REMARK ESU BASED ON R VALUE (A) : 0 .402 REMARK ESU BASED ON FREE R VALUE (A) : 0 . 320 REMARK ESU BASED ON MAXIMUM LIKELIHOOD (A) : 0 . 215 REMARK ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2) : 8 . 939 REMARK REMARK CORRELATION COEFFICIENTS. REMARK CORRELATION COEFFICIENT FO-FC : 0.909 REMARK CORRELATION COEFFICIENT FO-FC FREE : 0.859 REMARK REMARK RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK BOND LENGTHS REFINED ATOMS (A) 2440 0 . 042 0.022 REMARK BOND LENGTHS OTHERS (A) 2213 0 . 003 0.020 REMARK BOND ANGLES REFINED ATOMS (DEGREES) 3277 2 . 903 1.971 REMARK BOND ANGLES OTHERS (DEGREES) 5164 1 . 333 3.000 REMARK TORSION ANGLES, PERIOD 1 (DEGREES) 289 8 . 497 5.000 REMARK CHIRAL-CENTER RESTRAINTS (A**3) 348 0 . 173 0.200 REMARK GENERAL PLANES REFINED ATOMS (A) 2662 0 . 015 0.020 REMARK GENERAL PLANES OTHERS (A) 523 0 . 014 0.020 REMARK NON-BONDED CONTACTS REFINED ATOMS (A) 810 0 .295 0.200 REMARK NON-BONDED CONTACTS OTHERS (A) 2942 0.281 ; 0.200
REMARK NON-BONDED TORSION OTHERS (A) 1486 0.108 ; 0.200
REMARK H-BOND (X...Y) REFINED ATOMS (A) 141 0.266 ; 0.200
REMARK SYMMETRY VDW REFINED ATOMS (A) 13 0.347 ; 0.200
REMARK SYMMETRY VDW OTHERS (A) 51 0.349 ; 0.200
REMARK SYMMETRY H-BOND REFINED ATOMS (A) 8 0.256 ; 0.200
REMARK
REMARK ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT
REMARK
REMARK NCS RESTRAINTS STATISTICS
REMARK NUMBER OF NCS GROUPS : NULL
REMARK
REMARK
REMARK TLS DETAILS
REMARK NUMBER OF TLS GROUPS NULL
REMARK
REMARK
REMARK BULK SOLVENT MODELLING.
REMARK METHOD USED : BABINET MODEL WITH MASK
REMARK PARAMETERS FOR MASK CALCULATION
REMARK VDW PROBE RADIUS : 1.40
REMARK ION PROBE RADIUS : 0.80
REMARK SHRINKAGE RADIUS : 0.80
REMARK
REMARK OTHER REFINEMENT REMARKS:
REMARK HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
REMARK
ATOM N ARG A 142 21.741 54.485 78.204 52.65 A N
ATOM CA ARG A 142 20.627 55.145 77.496 53.10 A C
ATOM CB ARG A 142 19.659 55.683 78.529 53.01 A C
ATOM CG ARG A 142 18.523 56.534 78.040 53.94 A C
ATOM CD ARG A 142 17.809 57.111 79.216 54.56 A C
ATOM NE ARG A 142 18.664 58.188 79.725 55.39 A N
ATOM CZ ARG A 142 19.304 58.236 80.905 55.62 A C
ATOM NHl ARG A 142 19.213 57.245 81.819 54.89 A N
ATOM 9 NH2 ARG A 142 20.086 59.304 81.142 55.27 A N
ATOM 10 C ARG A 142 21.151 56.318 76.678 53.19 A C
ATOM 11 O ARG A 142 21.938 57.109 77.180 53.34 A O
ATOM 12 N LYS A 143 20.648 56.466 75.440 53.18 A N
ATOM 13 CA LYS A 143 21.078 57.498 74.440 52.06 A C
ATOM 14 CB LYS A 143 21.880 58.680 75.093 52.30 A C
ATOM 15 CG LYS A 143 20.997 59.748 75.712 50.91 A C
ATOM 16 CD LYS A 143 20.370 60.690 74.634 51.72 A C
ATOM 17 CE LYS A 143 19.463 61.808 75.291 51.83 A C
ATOM 18 NZ LYS A 143 18.517 61.196 76.311 51.81 A N
ATOM 19 C LYS A 143 21.800 56.907 73.210 51.27 A C
ATOM 20 O LYS A 143 21.313 57.041 72.081 50.90 A O
ATOM 21 N THR A 144 22.934 56.240 73.483 50.64 A N
ATOM 22 CA THR A 144 23.918 55.670 72.456 49.48 A C
ATOM 23 CB THR A 144 23.483 54.246 72.082 49.45 A C
ATOM 24 OGl THR A 144 23.301 53.545 73.333 50.83 A O
ATOM 25 CG2 THR A 144 24.625 53.479 71.315 48.64 A C
ATOM 26 C THR A 144 24.419 56.501 71.184 47.88 A C
ATOM 27 O THR A 144 23.729 57.384 70.709 47.62 A O
ATOM 28 N MET A 145 25.634 56.191 70.714 46.49 A N
ATOM 29 CA MET A 145 26.259 56.830 69.561 45.55 A C
ATOM 30 CB MET A 145 27.071 55.802 68.832 46.71 A C
ATOM 31 CG MET A 145 28.549 55.887 69.075 48.11 A C
ATOM 32 SD MET A 145 28.891 56.091 70.797 49.38 A S
ATOM 33 CE MET A 145 30.055 54.604 71.209 48.56 A C
ATOM 34 C MET A 145 25.365 57.612 68.568 44.14 A C
ATOM 35 O MET A 145 25.657 58.816 68.242 41.69 A O
ATOM 36 N ASN A 146 24.271 56.961 68.107 43.75 A N
ATOM 37 CA ASN A 146 23.229 57.698 67.255 44.40 A C
ATOM 38 CB ASN A 146 22.223 56.801 66.635 44.59 A C
ATOM 39 CG ASN A 146 22.869 55.556 66.127 45.90 A C
ATOM 40 ODl ASN A 146 22.210 54.477 66.014 45.39 A O
ATOM 41 ND2 ASN A 146 24.218 55.675 65.836 44.71 A N
ATOM 42 C ASN A 146 22.603 58.621 68.166 44.89 A C
ATOM 43 O ASN A 146 23.158 58.754 69.242 46.21 A O
ATOM 44 N ASP A 147 21.540 59.353 67.848 44.65 A N
ATOM 45 CA ASP A 147 21.231 60.514 68.782 43.82 A C
ATOM 46 CB ASP A 147 21.132 59.998 70.211 1.00 44.40 A C ATOM 47 CG ASP A 147 20.057 58.951 70.337 1.00 44.45 A C
ATOM 48 ODl ASP A 147 20.260 57.802 69.809 1.00 44.88 A O
ATOM 49 OD2 ASP A 147 18.949 59.263 70.843 1.00 45.23 A O
ATOM 50 C ASP A 147 22.213 61.705 68.754 1.00 42.78 A C
ATOM 51 O ASP A 147 21.796 62.890 68.980 1.00 42.68 A O
ATOM 52 N PHE A 148 23.496 61.400 68.476 1.00 41.39 A N
ATOM 53 CA PHE A 148 24.545 62.371 68.293 1.00 40.50 A C
ATOM 54 CB PHE A 148 25.613 62.187 69.353 1.00 40.99 A C
ATOM 55 CG PHE A 148 25.077 62.050 70.721 1.00 41.67 A C
ATOM 56 CDl PHE A 148 24.761 63.190 71.496 1.00 41.88 A C
ATOM 57 CEl PHE A 148 24.285 63.060 72.833 1.00 40.40 A C
ATOM 58 CZ PHE A 148 24.112 61.810 73.373 1.00 40.54 A C
ATOM 59 CE2 PHE A 148 24.458 60.657 72.621 1.00 41.11 A , C
ATOM 60 CD2 PHE A 148 24.957 60.785 71.308 1.00 41.79 A C
ATOM 61 C PHE A 148 25.226 62.323 66.912 1.00 39.26 A C
ATOM 62 O PHE A 148 25.611 61.274 66.370 1.00 37.59 A O
ATOM 63 N ASP A 149 25.375 63.515 66.364 1.00 38.05 A N
ATOM 64 CA ASP A 149 26.189 63.776 65.187 1.00 36.31 A C
ATOM 65 CB ASP A 149 25.778 65.191 64.688 1.00 34.62 A C
ATOM 66 CG ASP A 149 24.460 65.213 64.077 1.00 34.48 A C
ATOM 67 ODl ASP A 149 24.061 64.045 63.756 1.00 35.76 A O
ATOM 68 OD2 ASP A 149 23.754 66.253 63.835 1.00 34.85 A O
ATOM 69 C ASP A 149 27.671 63.789 65.519 1.00 34.79 A C
ATOM 70 O ASP A 149 28.112 64.604 66.255 1.00 34.52 A O
ATOM 71 N TYR A 150 28.458 62.881 64.999 1.00 34.97 A N
ATOM 72 CA TYR A 150 29.881 63.033 65.081 1.00 34.27 A C
ATOM 73 CB TYR A 150 30.521 61.746 64.718 1.00 35.68 A C
ATOM 74 CG TYR A 150 32.042 61.726 64.504 1.00 37.33 A C
ATOM 75 CDl TYR A 150 32.901 62.500 65.240 1.00 37.98 A C
ATOM 76 CEl TYR A 150 34.330 62.432 65.061 1.00 38.73 A C
ATOM 77 CZ TYR A 150 34.863 61.604 64.147 1.00 38.52 A C
ATOM 78 OH TYR A 150 36.210 61.513 63.990 1.00 40.25 A O
ATOM 79 CE2 TYR A 150 34.057 60.824 63.407 1.00 38.89 A C
ATOM 80 CD2 TYR A 150 32.620 60.857 63.598 1.00 38.28 A C
ATOM 81 C TYR A 150 30.393 64.208 64.252 1.00 33.65 A C
ATOM 82 O TYR A 150 30.583 64.093 63.027 1.00 33.22 A O
ATOM 83 N LEU A 151 30.673 65.338 64.949 1.00 31.45 A N
ATOM 84 CA LEU A 151 31.155 66.572 64.323 1.00 27.51 A C
ATOM 85 CB LEU A 151 30.754 67.798 65.124 1.00 27.55 A C
ATOM 86 CG LEU A 151 29.312 68.248 64.904 1.00 27.62 A C
ATOM 87 CDl LEU A 151 28.416 67.139 65.088 1.00 27.51 A C
ATOM 88 CD2 LEU A 151 28.870 69.341 65.855 1.00 28.42 A C
ATOM 89 C LEU A 151 32.624 66.584 64.113 1.00 26.44 A C
ATOM 90 O LEU A 151 33.093 66.741 63.044 1.00 28.63 A O
ATOM 91 N LYS A 152 33.401 66.477 65.127 1.00 24.77 A N
ATOM 92 CA LYS A 152 34.863 66.530 64.917 1.00 24.39 A C
ATOM 93 CB LYS A 152 35.380 68.008 64.767 1.00 24.56 A C
ATOM 94 CG LYS A 152 36.996 68.156 64.323 1.00 23.35 A C
ATOM 95 CD LYS A 152 37.315 69.497 63.831 1.00 22.43 A C
ATOM 96 CE LYS A 152 38.805 69.831 63.679 1.00 25.03 A C
ATOM 97 NZ LYS A 152 39.446 69.915 65.135 1.00 29.08 A N
ATOM 98 C LYS A 152 35.670 65.807 65.970 1.00 25.57 A C
ATOM 99 O LYS A 152 35.303 65.768 67.125 1.00 26.73 A O
ATOM 100 N LEU A 153 36.814 65.266 65.613 1.00 26.90 A N
ATOM 101 CA LEU A 153 37.719 64.715 66.613 1.00 27.43 A C
ATOM 102 CB LEU A 153 38.744 63.848 65.863 1.00 27.33 A C
ATOM 103 CG LEU A 153 39.624 62.983 66.753 1.00 28.01 A C
ATOM 104 CDl LEU A 153 38.784 61.962 67.600 1.00 27.27 A C
ATOM 105 CD2 LEU A 153 40.751 62.306 65.790 1.00 28.27 A C
ATOM 106 C LEU A 153 38.446 65.867 67.328 1.00 27.05 A C
ATOM 107 O LEU A 153 39.091 66.706 66.700 1.00 28.04 A O
ATOM 108 N LEU A 154 38.331 65.903 68.643 1.00 26.93 A N
ATOM 109 CA LEU A 154 39.115 66.789 69.488 1.00 26.91 A C
ATOM 110 CB LEU A 154 38.283 67.186 70.689 1.00 24.67 A C
ATOM 111 CG LEU A 154 36.970 67.766 70.249 1.00 24.39 A C
ATOM 112 CDl LEU A 154 36.092 67.928 71.540 1.00 22.12 A C
ATOM 113 CD2 LEU A 154 37.291 69.028 69.480 1.00 21.71 A C
ATOM 114 C LEU A 154 40.505 66.320 69.968 1.00 27.50 A C
ATOM 115 O LEU A 154 41.424 67.158 70.168 1.00 25.33 A O
ATOM 116 N- GLY A 155 40.654 65.001 70.154 1.00 28.69 A N
ATOM 117 CA GLY A 155 41.901 64.491 70.736 1.00 30.86 A C
ATOM 118 C GLY A 155 41.659 63.027 70.982 1.00 32.47 A C
ATOM 119 O GLY A 155 40.499 62.642 71.200 1.00 33.02 A O ATOM 120 N LYS A 156 42.728 62.230 70.911 1.00 34.95 A N
ATOM 121 CA LYS A 156 42.715 60.768 71.024 1.00 36.59 A C
ATOM 122 CB LYS A 156 42.730 60.126 69.631 1.00 36.67 A C
ATOM 123 CG LYS A 156 42.709 58.538 69.552 1.00 36.56 A C
ATOM 124 CD LYS A 156 42.495 58.100 68.019 1.00 36.72 A C
ATOM 125 CE LYS A 156 43.239 56.864 67.486 1.00 37.52 A C
ATOM 126 NZ LYS A 156 42.785 56.532 66.042 1.00 38.35 A N
ATOM 127 C LYS A 156 43.956 60.293 71.708 1.00 38.33 A C
ATOM 128 O LYS A 156 45.006 60.952 71.654 1.00 38.43 A O
ATOM 129 N GLY A 157 43.862 59.094 72.276 1.00 39.85 A N
ATOM 130 CA GLY A 157 45.036 58.432 72.793 1.00 41.89 A C
ATOM 131 C GLY A 157 44.578 57.205 73.561 1.00 43.47 A C
ATOM 132 O GLY A 157 43.473 57.224 74.164 1.00 43.92 A O
ATOM 133 N THR A 158 45.438 56.169 73.545 1.00 44.44 A N
ATOM 134 CA THR A 158 45.374 54.900 74.377 1.00 43.80 A C
ATOM 135 CB THR A 158 46.687 54.702 75.216 1.00 43.99 A C
ATOM 136 OGl THR A 158 47.048 55.927 75.857 1.00 44.22 A O
ATOM 137 CG2 THR A 158 47.949 54.451 74.287 1.00 43.41 A C
ATOM 138 C THR A 158 44.121 54.682 75.173 1.00 43.68 A C
ATOM 139 O THR A 158 43.330 53.793 74.871 1.00 44.37 A O
ATOM 140 N PHE A 159 43.902 55.475 76.194 1.00 43.89 A N
ATOM 141 CA PHE A 159 42.619 55.460 76.946 1.00 43.04 A C
ATOM 142 CB PHE A 159 42.664 56.696 77.904 1.00 44.68 A C
ATOM 143 CG PHE A 159 44.099 57.413 77.978 1.00 46.52 A C
ATOM 144 CDl PHE A 159 44.748 57.639 79.214 1.00 48.15 A C
ATOM 145 CEl PHE A 159 46.084 58.242 79.260 1.00 47.73 A C
ATOM 146 CZ PHE A 159 46.726 58.573 78.047 1.00 46.84 A C
ATOM 147 CE2 PHE A 159 46.086 58.342 76.861 1.00 46.60 A C
ATOM 148 CD2 PHE A 159 44.798 57.759 76.830 1.00 46.65 A C
ATOM 149 C PHE A 159 41.407 55.436 75.959 1.00 41.49 A C
ATOM 150 O PHE A 159 40.472 54.611 76.055 1.00 40.93 A O
ATOM 151 K GLY A 160 41.487 56.260 74.931 1.00 40.58 A N
ATOM 152 CA GLY A 160 40.393 56.516 74.024 1.00 40.13 A C
ATOM 153 C GLY A 160 40.467 57.990 73.553 1.00 39.83 A C
ATOM 154 O GLY A 160 41.523 58.622 73.383 1.00 39.17 A O
ATOM 155 N LYS A 161 39.323 58.550 73.258 1.00 38.92 A N
ATOM 156 CA LYS A 161 39.350 59.761 72.485 1.00 36.94 A C
ATOM 157 CB LYS A 161 39.437 59.439 70.961 1.00 38.00 A C
ATOM 158 CG LYS A 161 38.123 58.873 70.255 1.00 38.78 A C
ATOM 159 CD LYS 161 37.752 57.563 70.808 1.00 40.31 A C
ATOM 160 CE LYS A 161 38.937 56.498 70.593 1.00 41.02 A C
ATOM 161 NZ LYS A 161 38.414 55.156 70.599 1.00 41.50 A N
ATOM 162 C LYS A 161 38.120 60.559 72.779 1.00 35.49 A C
ATOM 163 O LYS A 161 37.060 60.030 73.228 1.00 35.27 A O
ATOM 164 N VAL A 162 38.249 61.828 72.428 1.00 33.77 A N
ATOM 165 CA VAL A 162 37.161 62.791 72.622 1.00 32.38 A C
ATOM 166 CB VAL A 162 37.641 63.880 73.602 1.00 31.62 A C
ATOM 167 CGl VAL A 162 36.464 64.585 74.080 1.00 30.97 A C
ATOM 168 CG2 VAL A 162 38.395 63.150 74.769 1.00 31.32 A C
ATOM 169 C VAL A 162 36.694 63.418 71.313 1.00 30.79 A C
ATOM 170 O VAL A 162 37.454 63.924 70.597 1.00 30.61 A O
ATOM 171 N ILE A 163 35.409 63.367 71.076 1.00 29.63 A N
ATOM 172 CA ILE A 163 34.825 63.918 69.901 1.00 29.29 A C
ATOM 173 CB ILE A 163 33.962 62.841 69.156 1.00 29.66 A C
ATOM 174 CGl ILE A 163 34.846 61.686 68.699 1.00 30.26 A C
ATOM 175 CDl ILE A 163 34.937 60.490 69.887 1.00 32.35 A C
ATOM 176 CG2 ILE A 163 33.215 63.534 68.020 1.00 28.96 A C
ATOM 177 C ILE A 163 33.909 65.052 70.196 1.00 29.61 A C
ATOM 178 O ILE A 163 33.143 64.994 71.029 1.00 30.32 A O
ATOM 179 N LEU A 164 33.922 66.044 69.409 1.00 29.62 A N
ATOM 180 CA LEU A 164 32.908 67.067 69.567 1.00 30.27 A C
ATOM 181 CB LEU A 164 33.405 68.363 68.852 1.00 29.16 A C
ATOM 182 CG LEU A 164 32.286 69.295 68.411 1.00 28.36 A C
ATOM 183 CDl LEU A 164 31.684 69.850 69.704 1.00 28.85 A C
ATOM 184 CD2 LEU A 164 32.842 70.406 67.552 1.00 25.86 A C
ATOM 185 C LEU A 164 31.656 66.499 68.919 1.00 30.36 A C
ATOM 186 O LEU A 164 31.784 65.910 67.863 1.00 31.22 A O
ATOM 187 N VAL A 165 30.480 66.731 69.478 1.00 30.79 A N
ATOM 188 CA VAL A 165 29.190 ' 66.204 68.909 1.00 31.31 A C
ATOM 189 CB VAL A 165 28.680 64.847 69.618 1.00 30.68 A C
ATOM 190 CGl VAL A 165 29.711 63.898 69.689 1.00 29.29 A C
ATOM 191 CG2 VAL A 165 28.184 65.065 71.087 1.00 29.68 A C
ATOM 192 C VAL A 165 28.011 67.153 69.061 1.00 32.37 A C ATOM 193 O VAL A 165 28.084 68.159 69.686 1.00 32.19 A O
ATOM 194 N ARG A 166 26.904 66.790 68.488 1.00 34.33 A N
ATOM 195 CA ARG A 166 25.647 67.523 68.599 1.00 35.40 A C
ATOM 196 CB ARG A 166 25.330 68.276 67.362 1.00 35.45 A C
ATOM 197 CG ARG A 1S6 24.035 68.964 67.439 1.00 34.72 A C
ATOM 198 CD ARG A 166 23.554 69.368 66.057 1.00 35.79 A C
ATOM 199 NE ARG A 166 24.388 70.375 65.460 1.00 35.88 A N
ATOM 200 CZ ARG A 166 24.930 70.353 64.257 1.00 35.46 A C
ATOM 201 NHl ARG A 166 24.800 69.277 63.413 1.00 36.31 A N
ATOM 202 NH2 ARG A 166 25.680 71.416 63.922 1.00 35.05 A N
ATOM 203 C ARG A 166 24.580 66.495 68.797 1.00 36.68 A C
ATOM 204 O ARG A 166 24.457 65.562 68.031 1.00 36.56 A O
ATOM 205 N GLU A 167 23.814 66.688 69.866 1.00 38.40 A N
ATOM 206 CA GLU A 167 22.612 65.896 70.134 1.00 39.40 A C
ATOM 207 CB GLU A 167 21.979 66.264 71.436 1.00 40.38 A C
ATOM 208 CG GLU A 167 22.032 65.198 72.498 1.00 41.70 A C
ATOM 209 CD GLU A 167 20.925" 65.443 73.514 1.00 42.86 A C
ATOM 210 OEl GLU A 167 20.890 64.794 74.581 1.00 42.73 A O
ATOM 211 OE2 GLU A 167 20.160 66.406 73.274 1.00 44.21 A O
ATOM 212 C GLU A 167 21.620 66.202 69.042 1.00 39.32 A C
ATOM 213 O GLU A 167 21.253 67.337 68.847 1.00 39.99 A O
ATOM 214 N LYS A 168 21.261 65.138 68.335 1.00 39.03 A N
ATOM 215 CA LYS A 168 20.316 65.156 67.232 1.00 39.21 A C
ATOM 216 CB LYS A 168 19.775 63.698 67.045 1.00 39.43 A C
ATOM 217 CG LYS A 168 20.041 62.931 65.841 1.00 38.85 A C
ATOM 218 CD LYS A 168 21.437 62.976 65.309 1.00 39.02 A C
ATOM 219 CK LYS A 168 21.394 62.259 63.944 1.00 39.45 A C
ATOM 220 NZ LYS A 168 20.678 60.971 64.148 1.00 39.95 A N
ATOM 221 C LYS A 168 19.173 66.193 67.513 1.00 39.27 • A C
ATOM 222 O LYS A 168 19.213 67.328 67.024 1.00 38.54 A O
ATOM 223 N ALA A 169 18.192 65.839 68.358 1.00 39.83 A N
ATOM 224 CA ALA A 169 16.928 66.637 68.435 1.00 39.95 A C
ATOM 225 CB ALA A 169 15.708 65.741 68.335 1.00 40.06 A C
ATOM 226' C ALA A 169 17.027 67.284 69.769 1.00 39.69 A C
ATOM 227 O ALA A 169 16.919 66.585 70.762 1.00 39.75 A O
ATOM 228 N SER A 170 17.317 68.609 69.733 1.00 40.13 A N
ATOM 229 CA SER A 170 18.020 69.378 70.785 1.00 38.19 A C
ATOM 230 CB SER A 170 18.815 68.541 71.812 1.00 39.06 A C
ATOM 231 OG SER A 170 19.877 69.356 72.398 1.00 39.51 A O
ATOM 232 C SER A 170 19.028 70.347 70.181 1.00 37.06 A C
ATOM 233 O SER A 170 18.921 71.621 70.436 1.00 36.88 A O
ATOM 234 N GLY A 171 20.073 69.812 69.523 1.00 34.82 A N
ATOM 235 CA GLY A 171 21.019 70.742 68.865 1.00 33.73 A C
ATOM 236 C GLY A 171 22.119 71.355 69.740 1.00 32.99 A C
ATOM 237 O GLY A 171 22.761 72.335 69.499 1.00 35.07 A O
ATOM 238 N LYS A 172 22.364 70.718 70.814 1.00 32.05 A N
ATOM 239 CA LYS A 172 23.397 71.164 71.646 1.00 31.28 A C
ATOM 240 CB LYS A 172 22.763 71.107 73.101 1.00 32.83 A C
ATOM 241 CG LYS A 172 21.459 72.051 73.243 1.00 32.63 A C
ATOM 242 CD LYS A 172 20.893 72.038 74.616 1.00 35.01 A C
ATOM 243 CE LYS A 172 20.023 73.355 74.998 1.00 35.56 A C
ATOM 244 NZ LYS A 172 19.846 73.366 76.602 1.00 34.91 A N
ATOM 245 C LYS A 172 24.692 70.325 71.452 1.00 30.44 A C
ATOM 246 O LYS A 172 24.628 69.120 71.170 1.00 30.92 A O
ATOM 247 N TYR A 173 25.850 71.008 71.636 1.00 28.76 A N
ATOM 248 CA TYR A 173 27.142 70.493 71.358 1.00 27.11 A C
ATOM 249 CB TYR A 173 28.064 71.622 70.879 1.00 27.05 A C
ATOM 250 CG TYR A 173 27.454 72.206 69.606 1.00 28.03 A C
ATOM 251 CDl TYR A 173 26.621 73.274 69.687 1.00 25.81 A C
ATOM 252 CEl TYR A 173 26.015 73.770 68.617 1.00 28.09 A C
ATOM 253 CZ TYR A 173 26.159 73.187 67.363 1.00 28.87 A C
ATOM 254 OH TYR A 173 25.456 73.770 66.313 1.00 30.99 A O
ATOM 255 CE2 TYR A 173 26.952 72.069 67.224 1.00 28.26 A C
ATOM 256 CD2 TYR A 173 27.600 71.555 68.367 1.00 26.56 A C
ATOM 257 C TYR A 173 27.670 69.964 72.562 1.00 27.10 A C
ATOM 258 O TYR A 173 27.507 70.556 73.511 1.00 28.31 A O
ATOM 259 N TYR A 174 28.339 68.821 72.509 1.00 27.33 A N
ATOM 260 CA TYR A 174 28.933 68.154 73.681 1.00 27.19 A C
ATOM 261 CB TYR A 174 28.076 66.930 74.063 1.00 27.49 A C
ATOM 262 CG TYR A 174 26.788 67.398 74.734 1.00 27.98 A C
ATOM 263 CDl TYR A 174 26.774 67.736 76.065 1.00 28.92 A C
ATOM 264 CEl TYR A 174 25.597 68.329 76.653 •1.00 28.92 A C
ATOM 265 CZ TYR A 174 24.458 68.518 75.853 1.00 29.60 A C ATOM 266 OH TYR A 174 23.286 69.005 76.393 1.00 29.82 A O
ATOM 267 CE2 TYR A 174 24.560 68.260 74.464 1.00 28.54 A C
ATOM 268 CD2 TYR A 174 25.681 67.700 73.975 1.00 27.67 A C
ATOM 269 C TYR A 174 30.354 67.710 73.374 1.00 28.27 A C
ATOM 270 O TYR A 174 30.688 67.637 72.206 1.00 28.17 A O
ATOM 271 N ALA A 175 31.135 67.400 74.417 1.00 28.74 A N
ATOM 272 CA ALA A 175 32.313 66.538 74.335 1.00 28.97 A C
ATOM 273 CB ALA A 175 33.489 67.073 75.255 1.00 28.25 A C
ATOM 274 C ALA A 175 31.998 65.077 74.736 1.00 29.23 A C
ATOM 275 O ALA A 175 31.424 64.819 75.760 1..00 29.89 A O
ATOM 276 N MET A 176 32.352 64.107 73.935 1.00 29.40 A N
ATOM 277 CA MET A 176 31.970 62.763 74.283 1.00 29.63 A C
ATOM 278 CB MET A 176 31.018 62.160 73.318 1.00 28.73 A C
ATOM 279 CG MET A 176 30.577 60.792 73.732 1.00 29.66 A C
ATOM 280 SD MET A 176 29.814 59.842 72.358 1.00 31.68 A S
ATOM 281 CE MET A 176 28.175 60.206 72.400 1.00 27.10 A C
ATOM 282 C MET A 176 33.175 61.988 74.460 1.00 29.02 A C
ATOM 283 O MET A 176 33.945 61.875 73.583 1.00 29.42 A O
ATOM 284 N IiYS A 177 33.418 61.580 75.685 1.00 30.52 A N
ATOM 285 CA LYS A 177 34.629 60.844 75.934 1.00 33.03 A C
ATOM 286 CB LYS A 177 35.058 61.197 77.315 1.00 34.61 A C
ATOM 287 CG LYS A 177 36.252 60.596 77.797 1.00 36.31 A C
ATOM 288 CD LYS A 177 36.457 61.009 79.301 1.00 38.41 A C
ATOM 289 CE LYS A 177 37.573 62.093 79.453 1.00 38.45 A C
ATOM 290 NZ LYS A 177 39.021 61.506 79.580 1.00 38.88 A N
ATOM 291 C LYS A 177 34.258 59.359 75.692 1.00 34.54 A C
ATOM 292 O LYS A 177 33.324 58.786 76.306 1.00 33.54 A O
ATOM 293 N ILE A 178 34.945 58.798 74.703 1.00 36.82 A N
ATOM 294 CA ILE A 178 34.763 57.419 74.364 1.00 38.92 A C
ATOM 295 CB ILE A 178 34.427 57.317 72.901 1.00 38.40 A C
ATOM 296 CGl ILE A 178 33.273 58.223 72.630 1.00 36.81 A C
ATOM 297 CDl ILE A 178 32.729 58.062 71.233 1.00 37.45 A C
ATOM 298 CG2 ILE A 178 33.908 55.841 72.521 1.00 38.83 A C
ATOM 299 C ILE A 178 36.061 56.692 74.796 1.00 40.75 A C
ATOM 300 O ILE A 178 37.178 57.149 74.507 1.00 40.18 A O
ATOM 301 N LEU A 179 35.840 55.610 75.578 1.00 42.04 A N
ATOM 302 CA LEU A 179 36.877 54.851 76.318 1.00 42.77 A C
ATOM 303 CB LEU A 179 36.705 55.155 77.802 1.00 43.78 A C
ATOM 304 CG LEU A 179 36.936 56.656 78.142 1.00 42.37 A C
ATOM 305 CDl LEU A 179 37.028 56.779 79.665 1.00 41.89 A C
ATOM 306 CD2 LEU A 179 38.231 57.234 77.497 1.00 41.96 A C
ATOM 307 C LEU A 179 37.004 53.307 76.083 1.00 43.65 A C
ATOM 308 O LEU A 179 36.029 52.525 76.041 1.00 42.21 A O
ATOM 309 N LYS A 180 38.256 52.914 75.823 1.00 45.45 A N
ATOM 310 CA LYS A 180 38.623 51.500 75.561 1.00 46.69 A C
ATOM 311 CB LYS A 180 39.924 51.414 74.773 1.00 48.03 A C
ATOM 312 CG LYS A 180 40.141 52.482 73.614 1.00 49.59 A C
ATOM 313 CD LYS A 180 41..671 52.569 73.147 1.00 48.90 A C
ATOM 314 CE ,LYS A 180 41.708 53.173 71.733 1.00 49.61 A C
ATOM 315 NZ LYS A 180 41.280 52.173 70.699 1.00 49.95 A N
ATOM 316 C LYS A 180 38.904 50.872 76.924 1.00 46.62 A C
ATOM 317 O LYS A 180 39.880 51.251 77.578 1.00 46.06 A O
ATOM 318 N LYS A 181 38.006 49.999 77.377 1.00 47.33 A N
ATOM 319 CA LYS A 181 38.091 49.376 78.710 1.00 47.88 A C
ATOM 320 CB LYS A 181 36.926 48.407 78.944 1.00 46.58 A C
ATOM 321 CG LYS A 181 35.546 49.094 78.808 1.00 46.76 A C
ATOM 322 CD LYS A 181 34.278 48.052 79.019 1.00 46.21 A C
ATOM 323 CE LYS A 181 32.823 48.728 78.839 1.00 45.65 A C
ATOM 324 NZ LYS A 181 31.670 48.039 78.039 1.00 45.12 A N
ATOM 325 C LYS A 181 39.434 48.683 78.874 1.00 47.77 A C
ATOM 326 O LYS A 181 40.266 49.194 79.610 1.00 46.15 A O
ATOM 327 N GLU A 182 39.651 47.577 78.156 1.00 49.46 A N
ATOM 328 CA GLU A 182 40.889 46.774 78.284 1.00 50.98 A C
ATOM 329 CB GLU A 182 40.944 45.62S 77.247 1.00 51.61 A C
ATOM 330 CG GLU A 182 40.993 46.060 75.782 1.00 51.94 A C
ATOM 331 CD GLU A 182 42.399 46.297 75.273 1.00 51.99 A C
ATOM 332 OEl GLU A 182 43.226 45.345 75.333 1.00 51.90 A O
ATOM 333 OE2 GLU A 182 42.675 47.450 74.802 1.00 52.08 A O
ATOM 334 C GLU A 182 42.224 47.583 78.246 1.00 51.82 A C
ATOM 335 O GLU A 182 43.337 47.005 78.121 1.00 52.07 A O
ATOM 336 N VAL A 183 42.112 48.913 78.301 1.00 52.23 A N
ATOM 337 CA VAL A 183 43.237 49.813 78.524 1.00 52.83 A C
ATOM 338 CB VAL A 183 43.114 51.060 77.564 1.00 53.32 A C ATOM 339 CGl VAL A 183 44.455 51.921 77.485 1.00 53.08 A C
ATOM 340 CG2 VAL A 183 42.707 50.588 76.152 1.00 53.55 A C
ATOM 341 C VAL A 183 43.176 50.222 79.997 1.00 52.90 A C
ATOM 342 O VAL A 183 44.138 50.057 80.772 1.00 52.73 A O
ATOM 343 N ILE A 184 42.011 50.765 80.384 1.00 53.27 A N
ATOM 344 CA ILE A 184 41.740 51.092 81.771 1.00 52.66 A C
ATOM 345 CB ILE A 184 40.222 51.246 81.934 1.00 52.14 A C
ATOM 346 CGl ILE A 184 39.747 52.596 81.401 1.00 50.69 A C
ATOM 347 CDl ILE A 184 38.355 52.544 81.081 1.00 48.65 A C
ATOM 348 CG2 ILE A 184 39.754 51.045 83.415 1.00 51.78 A C
ATOM 349 C ILE A 184 42.291 49.983 82.674 1.00 52.80 A C
ATOM 350 O ILE A 184 43.134 50.230 83.555 1.00 52.59 A O
ATOM 351 N ILE A 185 41.810 48.766 82.497 1.00 52.62 A N
ATOM 352 CA ILE A 185 42.437 47.615 83.211 1.00 53.34 A C
ATOM 353 CB ILE A 185 42.201 46.259 82.500 1.00 53.53 A C
ATOM 354 CGl ILE A 185 43.571 45.537 82.068 1.00 53.37 A C
ATOM 355 CDl ILE A 185 44.143 45.801 80.616 1.00 51.39 A C
ATOM 356 CG2 ILE A 185 41.149 46.426 81.376 1.00 52.69 A C
ATOM 357 C ILE A 185 43.935 47.849 83.312 1.00 53.66 A C
ATOM 358 O ILE A 185 44.456 47.918 84.396 1.00 54.00 A O
ATOM 359 N ALA A 186 44.601 48.004 82.170 1.00 54.01 A N
ATOM 360 CA ALA A 186 46.065 47.971 82.134 1.00 54.91 A C
ATOM 361 CB ALA A 186 46.614 47.707 80.666 1.00 54.89 A C
ATOM 362 C ALA A 186 46.707 49.214 82.767 1.00 54.88 A C
ATOM 363 O ALA A 186 47.945 49.368 82.709 1.00 55.05 A O
ATOM 364 N LYS A 187 45.881 50.090 83.351 1.00 54.63 A N
ATOM 365 CA LYS A 187 46.343 51.184 84.271 1.00 54.82 A C
ATOM 366 CB LYS A 187 45.646 52.532 83.962 1.00 54.16 A C
ATOM 367 CG LYS A 187 45.990 53.751 84.888 1.00 53.08 A C
ATOM 368 CD LYS A 187 47.505 54.070 85.083 1.00 51.94 A C
ATOM 369 CE LYS A 187 48.031 55.275 84.305 1.00 50.40 A C
ATOM 370 NZ LYS A 187 48.555 54.947 82.956 1.00 50.22 A N
ATOM 371 C LYS A 187 46.179 50.869 85.787 1.00 54.98 A C
ATOM 372 O LYS A 187 47.008 51.305 86.618 1.00 55.03 A O
ATOM 373 N ASP A 188 45.155 50.057 86.091 1.00 55.33 A N
ATOM 374 CA ASP A 188 44.464 50.015 87.381 1.00 54.59 A C
ATOM 375 CB ASP A 188 45.483 49.997 88.519 1.00 55.21 A C
ATOM 376 CG ASP A 188 44.990 49.246 89.726 1.00 56.46 A C
ATOM 377 ODl ASP A 188 45.846 48.748 90.506 1.00 57.37 A O
ATOM 378 OD2 ASP A 188 43.765 49.117 89.962 1.00 57.22 A O
ATOM 379 C ASP A 188 43.440 51.235 87.435 1.00 53.68 A C
ATOM 380 O ASP A 188 42.871 51.601 88.488 1.00 54.21 A O
ATOM 381 N GLU A 189 43.173 51.807 86.265 1.00 51.77 A N
ATOM 382 CA GLU A 189 42.234 52.938 86.134 1.00 50.55 A C
ATOM 383 CB GLU A 189 41.964 53.245 84.630 1.00 49.32 A C
ATOM 384 CG GLU A 189 41.882 54.695 84.263 1.00 48.09 A C
ATOM 385 CD GLU A 189 42.830 55.556 85.051 1.00 47.88 A C
ATOM 386 OEl GLU A 189 44.015 55.203 85.190 1.00 45.75 A O
ATOM 387 OE2 GLU A 189 42.330 56.585 85.570 1.00 47.78 A O
ATOM 388 C GLU A 189 40.919 52.666 86.875 1.00 49.75 A C
ATOM 389 O GLU A 189 40.709 53.267 87.898 1.00 49.47 A O
ATOM 390 N VAL A 190 40.148 51.696 86.347 1.00 48.74 A N
ATOM 391 CA VAL A 190 38.765 51.255 86.683 1.00 47.74 A C
ATOM 392 CB VAL A 190 38.689 49.671 86.882 1.00 47.99 A C
ATOM 393 CGl VAL A 190 37.255 49.163 86.876 1.00 47.41 A C
ATOM 394 CG2 VAL A 190 39.521 48.830 85.822 1.00 47.32 A C
ATOM 395 C VAL A 190 38.120 51.931 87.889 1.00 47.18 A C
ATOM 396 O VAL A 190 37.147 52.705 87.752 1.00 45.59 A O
ATOM 397 N ALA A 191 38.675 51.602 89.051 1.00 48.55 A N
ATOM 398 CA ALA A 191 38.649 52.433 90.280 1.00 49.27 A C
ATOM 399 CB ALA A 191 39.982 52.200 91.081 1.00 49.27 A C
ATOM 400 C ALA A 191 38.446 53.986 90.113 1.00 49.51 A C
ATOM 401 O ALA A 191 37.332 54.525 90.157 1.00 49.87 A O
ATOM 402 N HIS A 192 39.553 54.677 89.887 1.00 49.41 A N
ATOM 403 CA HIS A 192 39.475 56.116 89.659 1.00 49.82 A C
ATOM 404 CB HIS A 192 40.811 56.856 90.002 1.00 51.03 A C
ATOM 405 CG HIS A 192 40.596 58.265 90.536 1.00 53.23 A C
ATOM 406 NDl HIS A 192 41.626 59.080 90.979 1.00 53.22 A N
ATOM 407 CEl HIS A 192 41.118 60.242 91.376 1.00 53.06 A C
ATOM 408 NE2 HIS A 192 39.813 60.233 91.173 1.00 52.84 A N
ATOM 409 CD2 HIS A 192 39.463 59.017 90.640 1.00 53.05 A C
ATOM 410 C HIS A 192 38.995 56.358 88.255 1.00 48.48 A C
ATOM 411 O HIS A 192 39.571 57.177 87.545 1.00 50.19 A O ATOM 412 N THR A 193 37.974 55.636 87.821 1.00 47.12 A N
ATOM 413 CA THR A 193 37.358 55.953 86.572 1.00 45.75 A C
ATOM 414 CB THR A 193 37.747 54.926 85.515 1.00 46.11 A C
ATOM 415 OGl THR A 193 39.118 54.470 85.694 1.00 46.83 A O
ATOM 416 CG2 THR A 193 37.670 55.518 84.116 1.00 44.49 A C
ATOM 417 C THR A 193 35.879 55.969 86.772 1.00 45.26 A C
ATOM 418 O THR A 193 35.254 56.884 86.370 1.00 44.44 A O
ATOM 419 N LEU A 194 35.316 54.941 87.396 1.00 45.52 A N
ATOM 420 CA LEU A 194 33.906 54.963 87.905 1.00 45.53 A C
ATOM 421 CB LEU A 194 33.432 53.552 88.364 1.00 44.81 A C
ATOM 422 CG LEU A 194 33.441 52.584 87.146 1.00 45.12 A C
ATOM 423 CDl LEU A 194 33.108 51.140 87.539 1.00 45.43 A C
ATOM 424 CD2 LEU A 194 32.519 53.046 85.942 1.00 44.60 A C
ATOM 425 C LEU A 194 33.717 55.989 89.019 1.00 45.61 A C
ATOM 426 O LEU A 194 32.685 56.715 89.110 1.00 44.58 A O
ATOM 427 N THR A 195 34.750 56.107 89.816 1.00 45.51 A N
ATOM 428 CA THR A 195 34.828 57.172 90.816 1.00 46.16 A C
ATOM 429 CB THR A 195 36.139 56.974 91.527 1.00 46.42 A C
ATOM 430 OGl THR A 195 36.181 55.607 91.924 1.00 47.99 A O
ATOM 431 CG2 THR A 195 36.170 57.678 92.907 1.00 46.68 A C
ATOM 432 C THR A 195 34.632 58.617 90.265 1.00 45.87 A C
ATOM 433 O THR A 195 33.570 59.280 90.442 1.00 45.17 A O
ATOM 434 N GLU A 196 35.616 59.094 89.544 1.00 46.09 A N
ATOM 435 CA GLU A 196 35.412 60.345 88.852 1.00 46.10 A C
ATOM 436 CB GLU A 196 36.399 60.482 87.719 1.00 47.64 A C
ATOM 437 CG GLU A 196 37.582 59.489 87.766 1.00 50.92 A C
ATOM 438 CD GLU A 196 38.727 59.784 86.775 1.00 52.24 A C
ATOM 439 OEl GLU A 196 39.020 60.967 86.592 1.00 53.96 A O
ATOM 440 OE2 GLU A 196 39.383 58.848 86.238 1.00 52.47 A O
ATOM 441 C GLU A 196 33.956 60.478 88.367 1.00 45.43 A C
ATOM 442 O GLU A 196 33.282 61.457 88.643 1.00 45.92 A O
ATOM 443 N SER A 197 33.466 59.477 87.677 1.00 45.33 A N
ATOM 444 CA SER A 197 32.154 59.522 87.026 1.00 45.71 A C
ATOM 445 CB SER A 197 31.902 58.218 86.210 1.00 46.51 A C
ATOM 446 OG SER A 197 32.507 57.017 86.741 1.00 46.17 A O
ATOM 447 C SER A 197 30.996 59.795 87.937 1.00 45.67 A C
ATOM 448 O SER A 197 30.150 60.610 87.698 1.00 45.97 A O
ATOM 449 N ARG A 198 30.941 59.085 89.014 1.00 46.44 A N
ATOM 450 CA ARG A 198 30.021 59.416 90.077 1.00 46.48 A C
ATOM 451 CB ARG A 198 30.618 58.729 91.293 1.00 48.07 A C
ATOM 452 CG ARG A 198 30.248 59.176 92.756 1.00 49.38 A C
ATOM 453 CD ARG A 198 31.124 58.430 93.773 1.00 50.59 A C
ATOM 454 NE ARG A 198 30.819 56.979 94.003 1.00 49.80 A N
ATOM 455 CZ ARG A 198 31.155 55.907 93.247 1.00 48.86 A C
ATOM 456 NHl ARG A 198 31.728 55.977 92.077 1.00 47.87 A N
ATOM 457 NH2 ARG A 198 30.807 54.679 93.661 1.00 50.42 A N
ATOM 458 C ARG A 198 29.866 60.903 90.429 1.00 46.92 A C
ATOM 459 O ARG A 198 28.771 61.474 90.349 1.00 45.37 A O
ATOM 460 N VAL A 199 30.992 61.472 90.885 1.00 47.12 A N
ATOM 461 CA VAL A 199 31.134 62.870 91.290 1.00 47.46 A C
ATOM 462 CB VAL A 199 32.635 63.150 91.571 1.00 47.43 A C
ATOM 463 CGl VAL A 199 32.956 64.740 91.728 1.00 45.97 A C
ATOM 464 CG2 VAL A 199 33.158 62.246 92.720 1.00 46.81 A C
ATOM 465 C VAL A 199 30.705 63.901 90.222 1.00 47.39 A C
ATOM 466 O VAL A 199 30.325 65.017 90.554 1.00 48.23 A O
ATOM 467 N LEU A 200 30.818 63.555 88.954 1.00 47.15 A N
ATOM 468 CA LEU A 200 30.403 64.491 87.877 1.00 47.55 A C
ATOM 469 CB LEU A 200 31.054 64.117 86.548 1.00 48.39 A C
ATOM 470 CG LEU A 200 32.560 64.417 86.385 1.00 49.11 A C
ATOM 471 CDl LEU A 200 32.870 64.360 84.929 1.00 49.59 A C
ATOM 472 CD2 LEU A 200 33.025 65.817 87.023 1.00 49.12 A C
ATOM 473 C LEU A 200 28.909 64.695 87.606 1.00 47.54 A C
ATOM 474 O LEU A 200 28.577 65.719 86.937 1.00 47.45 A O
ATOM 475 N LYS A 201 28.025 63.794 88.054 1.00 47.28 A N
ATOM 476 CA LYS A 201 26.610 63.979 87.746 1.00 48.76 A C
ATOM 477 CB LYS A 201 25.984 62.715 87.135 1.00 50.83 A C
ATOM 478 CG LYS A 201 24.448 62.925 86.638 1.00 51.68 A C
ATOM 479 CD LYS A 201 24.201 63.549 85.194 1.00 51.85 A C
ATOM 480 CE LYS A 201 23.751 65.029 85.289 1.00 51.77 A C
ATOM 481 NZ LYS A 201 24.733 65.785 86.091 1.00 51.42 A N
ATOM 482 C LYS A 201 25.724 64.458 88.878 1.00 49.04 A C
ATOM 483 O LYS A 201 24.928 65.419 88.701 1.00 49.46 A O
ATOM 484 N ASN A 202 25.778 63.812 90.034 1.00 47.64 A N ATOM 485 CA ASN A 202 25.235 64.463 91.229 1.00 45.20 A C
ATOM 486 CB ASN A 202 25.289 63.449 92.371 1.00 47.83 A C
ATOM 487 CG ASN A 202 26.603 62.803 92.403 1.00 50.21 A C
ATOM 488 ODl ASN A 202 26.973 62.023 93.364 1.00 51.68 A O
ATOM 489 ND2 ASN A 202 27.414 63.136 91.295 1.00 51.27 A N
ATOM 490 C ASN A 202 25.960 65.740 91.710 1.00 42.27 A C
ATOM 491 O ASN A 202 25.655 66.170 92.859 1.00 42.91 A O
ATOM 492 N THR A 203 26.932 66.315 90.976 1.00 38.13 A N
ATOM 493 CA THR A 203 27.450 67.629 91.375 1.00 34.24 A C
ATOM 494 CB THR A 203 28.959 67.711 91.667 1.00 32.75 A C
ATOM 495 OGl THR A 203 29.695 67.337 90.508 1.00 30.56 A O
ATOM 496 CG2 THR A 203 29.425 66.894 92.796 1.00 31.80 A C
ATOM 497 C THR A 203 27.272 68.683 90.277 1.00 32.97 A C
ATOM 498 O THR A 203 27.398 68.343 89.104 1.00 32.25 A O
ATOM 499 N ARG A 204 27.105 69.955 90.695 1.00 31.93 A N
ATOM 500 CA ARG A 204 26.904 71.121 89.839 1.00 29.80 A C
ATOM 501 CB ARG A 204 25.452 71.471 89.766 1.00 30.31 A C
ATOM 502 CG ARG A '204 25.222 72.403 88.611 1.00 35.36 A C
ATOM 503 CD ARG A 204 25.335 71.739 87.187 1.00 38.59 A C
ATOM 504 NE ARG A 204 24.573 70.463 87.076 1.00 42.06 A N
ATOM 505 CZ ARG A 204 23.256 70.294 87.274 1.00 42.75 A C
ATOM 506 NHl ARG A 204 22.441 71.294 87.609 1.00 43.54 A N
ATOM 507 NH2 ARG A 204 22.770 69.081 87.128 1.00 43.58 A N
ATOM 508 C ARG A 204 27.652 72.399 90.315 1.00 26.90 A C
ATOM 509 O ARG A 204 27.432 72.836 91.400 1.00 26.88 A O
ATOM 510 N HIS A 205 28.427 73.026 89.458 1.00 24.31 A N
ATOM 511 CA HIS A 205 29.346 74.122 89.863 1.00 20.89 A C
ATOM 512 CB HIS A 205 30.591 73.620 90.784 1.00 18.83 A C
ATOM 513 CG HIS A 205 31.373 74.800 91.317 1.00 18.62 A C
ATOM 514 NDl HIS A 205 30.903 75.609 92.338 1.00 17.73 A N
ATOM 515 CEl HIS A 205 31.715 76.629 92.514 1.00 15.19 A C
ATOM 516 NE2 HIS A 205 32.690 76.530 91.637 1.00 17.68 A N
ATOM 517 CD2 HIS A 205 32.509 75.394 90.882 1.00 18.35 A C
ATOM 518 C HIS A 205 29.836 74.765 88.539 1.00 18.95 A C
ATOM 519 O HIS A 205 30.187 74.110 87.608 1.00 19.48 A O
ATOM 520 N PRO A 206 29.944 76.081 88.489 1.00 18.85 A N
ATOM 521 CA PRO A 206 30.469 76.809 87.314 1.00 17.79 A C
ATOM 522 CB PRO A 206 30.300 78.267 87.735 1.00 16.74 A C
ATOM 523 CG PRO A 206 30.076 78.318 88.999 1.00 16.84 A C
ATOM 524 CD PRO A 206 29.522 77.034 89.506 1.00 18.31 A C
ATOM 525 C PRO A 206 31.885 76.443 86.938 1.00 17.21 A C
ATOM 526 O PRO A 206 32.249 76.581 85.754 1.00 18.06 A O
ATOM 527 N PHE A 207 32.694 75.940 87.888 1.00 15.44, A N
ATOM 528 CA PHE A 207 34.059 75.661 87.493 1.00 15.73 A C
ATOM 529 CB PHE A 207 35.047 76.453 88.323 1.00 13.48 A C
ATOM 530 CG PHE A 207 34.698 77.959 88.381 1.00 9.54 A C
ATOM 531 CDl PHE A 207 34.527 78.694 87.293 1.00 9.22 A C
ATOM 532 CEl PHE A 207 34.199 79.991 87.423 1.00 8.96 A C
ATOM 533 CZ PHE A 207 34.003 80.517 88.668 1.00 5.09 A C
ATOM 534 CE2 PHE A 207 34.097 79.843 89.701 1.00 4.22 A C
ATOM 535 CD2 PHE A 207 34.463 78.568 89.599 1.00 10.29 A C
ATOM 536 C PHE A 207 34.400 74.200 87.347 1.00 16.67 A C
ATOM 537 O PHE A 207 35.574 73.785 87.201 1.00 17.52 A O
ATOM 538 N LEU A 208 33.358 73.408 87.293 1.00 17.25 A N
ATOM 539 CA LEU A 208 33.537 71.938 87.218 1.00 18.82 A C
ATOM 540 CB LEU A 208 32.739 71.253 88.359 1.00 17.67 A C
ATOM 541 CG LEU A 208 33.589 71.112 89.641 1.00 17.42 A C
ATOM 542 CDl LEU A 208 32.757 70.171 90.657 1.00 19.19 A C
ATOM 543 CD2 LEU A 208 35.026 70.592 89.432 1.00 14.10 A C
ATOM 544 C LEU A 208 32.943 71.615 85.902 1.00 18.53 A C
ATOM 545 O LEU A 208 31.751 71.882 85.710 1.00 21.80 A O
ATOM 546 N THR A 209 33.697 71.060 84.999 1.00 19.38 A N
ATOM 547 CA THR A 209 33.014 70.477 83.815 1.00 21.21 A C
ATOM 548 CB THR A 209 33.995 69.877 82.882 1.00 20.76 A C
ATOM 549 OGl THR A 209 35.053 70.799 82.733 1.00 23.70 A O
ATOM 550 CG2 THR A 209 33.365 69.838 81.369 1.00 23.36 A C
ATOM 551 C THR A 209 31.894 69.442 84.135 1.00 20.13 A C
ATOM 552 O THR A 209 32.060 68.489 84.857 1.00 21.60 A O
ATOM 553 N SER A 210 30.731 69.663 83.603 1.00 21.29 A N
ATOM 554 CA SER A 210 29.587 68.806 83.871 1.00 24.04 A C
ATOM 555 CB SER A 210 28.312 69.611 83.850 1.00 24.35 A C
ATOM 556 OG SER A 210 27.338 68.759 84.624 1.00 30.06 A O
ATOM 557 C SER A 210 29.340 67.590 82.941 1.00 24.54 A C ATOM 558 O SER A 210 29.538 67.664 81.695 1. 00 24 . 11 A O
ATOM 559 N LEU A 211 28.932 66.490 83.523 1 . 00 25 . 71 A N
ATOM 560 CA LEU A 211 28.737 65.205 82.818 1 . 00 27 . 62 A C
ATOM 561 CB LEU A 211 29.017 64.013 83.730 1 . 00 28 .38 A C
ATOM 562 CG LEU A 211 28.658 62.576 83.236 1.00 29 .34 A C
ATOM 563 CDl LEU A 211 29.222 62.364 81.769 29 . 75 A C
ATOM 564 CD2 LEU A 211 29.314 61.679 84.074 30 . 66 A C
ATOM 565 C LEU A 211 27.302 65.128 82.509 27 . 78 A C
ATOM 566 O LEU A 211 26.609 64.912 83.415 26 . 22 A O
ATOM 567 N LYS A 212 26.838 65.436 81.277 30 . 80 A N
ATOM 568 CA LYS A 212 25.379 65.310 80.865 31 . 78 A C
ATOM 569 CB LYS A 212 25.144 65.998 79.564 33 .44 A C
ATOM 570 CG LYS A 212 23.679 66.185 79.012 34 . 62 A C
ATOM 571 CD LYS A 212 23.009 67.423 79.478 33 . 57 A C
ATOM 572 CE LYS A 212 21.433 67.372 79.233 34 . 69 A C
ATOM 573 NZ LYS A 212 21.016 68.812 79.324 33 . 70 A N
ATOM 574 C LYS A 212 24.830 63.859 80.799 33 . 16 A C
ATOM 575 O LYS A 212 23.684 63.686 81.249 34 . 03 A O
ATOM 576 N TYR A 213 25.609 62.873 80.255 34 . 02 A N
ATOM 577 CA TYR A 213 25.191 61.434 80.076 1 . 00 35 . 89 A C
ATOM 578 CB TYR A 213 24.521 61.118 78.767 1 . 00 34 . 43 A C
ATOM 579 CG TYR A 213 23.400 62.066 78.381 1 . 00 33 . 94 A C
ATOM 580 CDl TYR A 213 22.384 62.300 79.207 1 . 00 33 . 75 A C
ATOM 581 CEl TYR A 213 21.380 63.252 78.900 1 . 00 34 . 77 A C
ATOM 582 CZ TYR A 213 21.417 63.870 77.740 1 . 00 34 . 91 A C
ATOM 583 OH TYR A 213 20.438 64.764 77.302 1.00 34 ..9900 A O
ATOM 584 CE2 TYR A 213 22.481 63.633 76.907 1.00 34..6699 A C
ATOM 585 CD2 TYR A 213 23.444 62.769 77.241 1.00 34.29 A C
ATOM 586 C TYR A 213 26.365 60.574 80.134 1.00 38.16 A C
ATOM 587 O TYR A 213 27.488 61.045 79.926 1.00 38.95 A O
ATOM 588 N SER A 214 26.129 59.291 80.428 1.00 40.57 A N
ATOM 589 CA SER A 214 27.226 58.290 80.435 1.00 42.99 A C
ATOM 590 CB SER A 214 27.577 58.023 81.871 1.00 42.45 A C
ATOM 591 OG SER A 214 26.381 57.682 82.536 1.00 44.20 A O
ATOM 592 C SER A 214 26.930 56.886 79.808 1.00 45.25 A C
ATOM 593 O SER A 214 27.739 55.952 80.012 1.00 46.53 A O
ATOM 594 N PHE A 215 25.818 56.722 79.081 1.00 46.55 A N
ATOM 595 CA PHE A 215 25.478 55.434 78.499 1.00 47.98 A C
ATOM 596 CB PHE A 215 24.515 55.558 77.282 1.00 48.46 A C
ATOM 597 CG PHE A 215 25.192 56.076 76.092 1.00 49.92 A C
ATOM 598 CDl PHE A 215 25.985 55.267 75.364 1.00 49.55 A C
ATOM 599 CEl PHE A 215 26.693 55.762 74.277 1.00 50.50 A C
ATOM 600 CZ PHE A 215 26.646 57.109 73.939 1.00 50.19 A C
ATOM 601 CE2 PHE A 215 25.869 57.920 74.679 1.00 50.34 A C
ATOM 602 CD2 PHE A 215 25.175 57.417 75.805 1.00 49.82 A C
ATOM 603 C PHE A 215 26.697 54.584 78.119 1.00 48.80 A C
ATOM 604 O PHE A 215 27.745 55.049 77.988 1.00 47.73 A O
ATOM 605 N GLN A 216 26.450 53.299 77.875 1.00 50.25 A N
ATOM 606 CA GLN A 216 27.462 52.248 77.917 1.00 50.98 A C
ATOM 607 CB GLN A 216 27.203 51.281 79.109 1.00 51.55 A C
ATOM 608 CG GLN A 216 26.178 51.813 80.117 1.00 51.52 A C
ATOM 609 CD GLN A 216 24.767 51.315 79.849 1.00 51.51 A C
ATOM 610 OEl GLN A 216 24.242 51.547 78.752 1.00 51.95 A O
ATOM 611 NE2 GLN A 216 24.146 50.630 80.851 1.00 50.05 A N
ATOM 612 C GLN A 216 27.343 51.478 76.641 1.00 50.85 A C
ATOM 613 O GLN A 216 26.219 51.316 76.153 1.00 51.14 A O
ATOM 614 N THR A 217 28.483 51.017 76.120 1.00 50.78 A N
ATOM 615 CA THR A 217 28.482 50.125 74.941 1.00 51.21 A C
ATOM 616 CB THR A 217 28.655 50.896 73.606 00 51.01 A C
ATOM 617 OGl THR A 217 29.647 50.284 72.819 00 48.84 A O
ATOM 618 CG2 THR A 217 29.264 52.331 73.829 1.00 5 511..1144 A C
ATOM 619 C THR A 217 29.619 49.157 75.074 1.00 51.57 A C
ATOM 620 O THR A 217 30.632 49.503 75.650 1.00 52.43 A O
ATOM 621 N LYS A 218 29.453 47.953 74.550 1.00 51.68 A N
ATOM 622 CA LYS A 218 30.449 46.901 74.679 1.00 52.21 A C
ATOM 623 CB LYS A 218 30.202 45.858 73.575 1.00 52.76 A C
ATOM 624 CG LYS A 218 28.791 45.244 73.589 1.00 51.15 A C
ATOM 625 CD LYS A 218 27.790 46.105 72.792 1.00 50.51 A C
ATOM 626 CE LYS A 218 27.076 45.381 71.606 1.00 49.36 A C
ATOM 627 NZ LYS A 218 26.315 46.467 70.887 1.00 49.11 A N
ATOM 628 C LYS A 218 31.922 47.471 74.679 1.00 52.75 A C
ATOM 629 O LYS A 218 32.279 48.274 73.838 1.00 51.73 A O
ATOM 630 N ASP A 219 32.756 47.092 75.675 1.00 53.27 A N ATOM 631 CA ASP A 219 34.074 47.824 76.060 1.00 53.11 A C
ATOM 632 CB ASP A 219 35.293 46.934 75.703 1.00 53.25 A C
ATOM 633 CG ASP A 219 35.453 46.836 74.226 1.00 52.28 A C
ATOM 634 ODl ASP A 219 34.604 47.562 73.581 1.00 51.21 A O
ATOM 635 OD2 ASP A 219 36.310 46.117 73.627 1.00 51.16 A O
ATOM 636 C ASP A 219 34.394 49.320 75.581 1.00 53.06 A C
ATOM 637 O ASP A 219 35.607 49.694 75.327 1.00 53.39 A O
ATOM 638 N ARG A 220 33.358 50.183 75.531 1.00 52.09 A N
ATOM 639 CA ARG A 220 33.523 51.548 74.986 1.00 50.34 A C
ATOM 640 CB ARG A 220 32.480 51.871 73.873 1.00 49.90 A C
ATOM 641 CG ARG A 220 33.053 52.283 72.502 1.00 51.15 A C
ATOM 642 CD ARG A 220 34.117 51.305 71.934 1.00 52.38 A C
ATOM 643 NE ARG A 220 33.552 49.920 71.892 1.00 53.79 A N
ATOM 644 CZ ARG A 220 33.041 49.309 70.817 1.00 53.66 A C
ATOM 645 NHl ARG A 220 33.089 49.905 69.612 1.00 54.11 A N
ATOM 646 NH2 ARG A 220 32.507 48.084 70.954 1.00 53.93 A N
ATOM 647 C ARG A 220 33.464 52.544 76.115 1.00 49.26 A C
ATOM 648 O ARG A 220 34.423 53.292 76.316 1.00 49.04 A O
ATOM 649 N LEU A 221 32.348 52.546 76.855 1.00 47.92 A N
ATOM 650 CA LEU A 221 32.063 53.602 77.879 1.00 45.71 A C
ATOM 651 CB LEU A 221 32.901 53.393 79.115 1.00 46.45 A C
ATOM 652 CG LEU A 221 32.399 52.109 79.787 1.00 47.55 A C
ATOM 653 CDl LEU A 221 33.639 51.440 80.471 1.00 47.64 A C
ATOM 654 CD2 LEU A 221 31.175 52.259 80.762 1.00 47.78 A C
ATOM 655 C LEU A 221 32.158 55.064 77.425 1.00 44.09 A C
ATOM 656 O LEU A 221 33.241 55.637 77.260 1.00 43.35 A O
ATOM 657 N CYS A 222 30.954 55.615 77.279 1.00 42.95 A N
ATOM 658 CA CYS A 222 30.670 56.956 76.812 1.00 40.85 A C
ATOM 659 CB CYS A 222 29.510 56.899 75.859 1.00 41.71 A C
ATOM 660 SG CYS A 222 29.889 55.817 74.497 1.00 43.99 A S
ATOM 661 C CYS A 222 30.252 57.923 77.897 1.00 39.14 A C
ATOM 662 O CYS A 222 29.366 57.593 78.748 1.00 37.24 A O
ATOM 663 N PHE A 223 30.894 59.109 77.837 1.00 37.14 A N
ATOM 664 CA PHE A 223 30.639 60.220 78.734 1.00 35.96 A C
ATOM 665 CB PHE A 223 31.862 60.431 79.586 1.00 35.95 A C
ATOM 666 CG PHE A 223 32.344 59.207 80.301 1.00 36.16 A C
ATOM 667 CDl PHE A 223 31.799 58.827 81.515 1.00 34.91 A C
ATOM 668 CEl PHE A 223 32.244 57.754 82.164 1.00 35.06 A C
ATOM 669 CZ PHE A 223 33.290 56.972 81.611 1.00 36.65 A C
ATOM 670 CE2 PHE A 223 33.863 57.321 80.434 1.00 36.15 A C
ATOM 671 CD2 PHE A 223 33.383 58.447 79.769 1.00 36.15 A C
ATOM 672 C PHE A 223 30.339 61.524 77.935 1.00 35.20 A C
ATOM 673 O PHE A 223 31.225 62.075 77.231 1.00 34.62 A O
ATOM 674 N VAL A 224 29.111 62.008 78.048 1.00 33.81 A N
ATOM 675 CA VAL A 224 28.691 63.162 77.367 1.00 34.14 A C
ATOM 676 CB VAL A 224 27.162 63.046 76.876 1.00 34.53 A C
ATOM 677 CGl VAL A 224 26.683 64.250 76.110 1.00 34.51 A C
ATOM 678 CG2 VAL A 224 26.948 61.849 75.926 1.00 34.71 A C
ATOM 679 C VAL A 224 28.941 64.333 78.353 1.00 34.22 A C
ATOM 680 O VAL A 224 28.228 64.424 79.340 1.00 34.56 A O
ATOM 681 N MET A 225 29.920 65.215 78.074 1.00 33.68 A N
ATOM 682 CA MET A 225 30.280 66.346 78.926 1.00 33.59 A C
ATOM 683 CB MET A 225 31.792 66.267 79.290 1.00 36.06 A C
ATOM 684 CG MET A 225 31.999 65.067 80.273 1.00 38.98 A C
ATOM 685 SD MET A 225 33.716 64.525 80.500 1.00 44.18 A S
ATOM 686 CE MET A 225 34.070 65.439 82.335 1.00 43.45 A C
ATOM 687 C MET A 225 29.963 67.606 78.182 1.00 32.77 A C
ATOM 688 O MET A 225 29.981 67.562 76.986 1.00 31.86 A O
ATOM 689 N GLU A 226 29.655 68.723 78.887 1.00 31.13 A N
ATOM 690 CA GLU A 226 29.652 70.042 78.244 1.00 29.78 A C
ATOM 691 CB GLU A 226 29.399 71.203 79.213 1.00 28.90 A C
ATOM 692 CG GLU A 226 30.459 71.375 80.320 1.00 29.60 A C
ATOM 693 CD GLU A 226 30.157 72.503 81.317 1.00 27.59 A C
ATOM 694 OEl GLU A 226 30.346 72.355 82.510 1.00 25.88 A O
ATOM 695 OE2 GLU A 226 29.753 73.542 80.795 1.00 27.69 A O
ATOM 696 C GLU A 226 30.896 70.301 77.456 1.00 29.48 A C
ATOM 697 O GLU A 226 31.927 70.078 77.892 1.00 31.03 A O
ATOM 698 N TYR A 227 30.754 70.792 76.244 1.00 28.96 A N
ATOM 699 CA TYR A 227 31.878 71.196 75.408 1.00 25.94 A C
ATOM 700 CB TYR A 227 ^31.422 71.489 73.930 1.00 24.93 A C
ATOM 701 CG TYR A 227 32.506 71.917 72.984 1.00 24.04 A C
ATOM 702 CDl TYR A 227 33.766 71.265 73.000 1.00 22.75 A C
ATOM 703 CEl TYR A 227 34.780 71.658 72.173 1.00 23.32 A C ATOM 704 CZ TYR A 227 34.543 72.634 71.219 1.00 23.25 A C
ATOM 705 OH TYR A 227 35.590 72.860 70.421 1.00 26.24 A O
ATOM 706 CE2 TYR A 227 33.321 73.307 71.152 1.00 24.20 A C
ATOM 707 CD2 TYR A 227 32.309 72.963 72.079 1.00 24.52 A C
ATOM 708 C TYR A 227 32.563 72.411 75.945 1.00 25.56 A C
ATOM 709 O TYR A 227 31.924 73.452 76.022 1.00 25.99 A O
ATOM 710 N VAL A 228 33.885 72.303 76.185 1.00 23.55 A N
ATOM 711 CA VAL A 228 34.637 73.483 76.659 1.00 23.42 A C
ATOM 712 CB VAL A 228 35.287 73.222 78.116 1.00 23.64 A C
ATOM 713 CGl VAL A 228 35.491 74.523 78.698 1.00 24.19 A C
ATOM 714 CG2 VAL A 228 34.301 72.330 78.992 1.00 23.99 A C
ATOM 715 C VAL A 228 35.771 73.826 75.762 1.00 22.74 A C
ATOM 716 O VAL A 228 36.701 72.997 75.619 1.00 21.17 A O
ATOM 717 N ASN A 229 35.715 75.023 75.159 1.00 22.49 A N
ATOM 718 CA ASN A 229 36.663 75.258 74.012 1.00 23.20 A C
ATOM 719 CB ASN A 229 35.908 75.362 72.699 1.00 22.65 A C
ATOM 720 CG ASN A 229 35.113 76.687 72.528 1.00 26.11 A C
ATOM 721 ODl ASN A 229 34.747 77.086 71.353 1.00 29.13 A O
ATOM 722 ND2 ASN A 229 34.725 77.294 73.629 1.00 25.81 A N
ATOM 723 C ASN A 229 37.792 76.369 74.096 1.00 21.53 A C
ATOM 724 O ASN A 229 38.261 76.809 73.051 1.00 20.45 A O
ATOM 725 N GLY A 230 38.171 76.781 75.304 1.00 20.63 A N
ATOM 726 CA GLY A 230 39.147 77.865 75.472 1.00 20.20 A C
ATOM 727 C GLY A 230 40.530 77.343 75.586 1.00 19.78 A C
ATOM 728 O GLY A 230 41.469 78.095 75.732 1.00 18.85 A O
ATOM 729 N GLY A 231 40.703 76.053 75.585 1.00 20.28 A N
ATOM 730 CA GLY A 231 42.019 75.439 75.576 1.00 22.17 A C
ATOM 731 C GLY A 231 42.537 74.846 76.853 1.00 23.81 A C
ATOM 732 O GLY A 231 42.008 75.156 77.923 1.00 23.84 A O
ATOM 733 N GLU A 232 43.577 74.029 76.750 1.00 24.38 A N
ATOM 734 CA GLU A 232 44.252 73.444 77.899 1.00 26.07 A C
ATOM 735 CB GLU A 232 45.162 72.282 77.454 1.00 26.77 A C
ATOM 736 CG GLU A 232 44.570 70.873 77.316 1.00 29.85 A C
ATOM 737 CD GLU A 232 44.685 70.177 78.685 1.00 34.06 A C
ATOM 738 OEl GLU A 232 44.166 70.858 79.639 1.00 36.63 A O
ATOM 739 OE2 GLU A 232 45.336 69.061 78.849 1.00 34.46 A O
ATOM 740 C GLU A 232 45.138 74.498 78.646 1.00 25.95 A C
ATOM 741 O GLU A 232 46.073 75.038 78.117 1.00 25.78 A O
ATOM 742 N LEU A 233 44.967 74.635 79.926 1.00 25.89 A N
ATOM 743 CA LEU A 233 45.864 75.492 80.635 1.00 27.45 A C
ATOM 744 CB LEU A 233 45.524 75.448 82.141 1.00 26.37 A C
ATOM 745 CG LEU A 233 44.811 76.735 82.527 1.00 27.21 A C
ATOM 746 CDl LEU A 233 44.633 76.744 84.067 1.00 28.67 A C
ATOM 747 CD2 LEU A 233 45.523 77.901 82.097 1.00 24.84 A C
ATOM 748 C LEU A 233 47.350 75.178 80.466 1.00 28.09 A C
ATOM 749 O LEU A 233 48.142 76.071 80.455 1.00 28.58 A O
ATOM 750 N PHE A 234 47.696 73.888 80.438 1.00 28.78 A N
ATOM 751 CA PHE A 234 49.048 73.410 80.131 1.00 30.11 A C
ATOM 752 CB PHE A 234 49.006 71.916 79.954 1.00 32.27 A C
ATOM 753 CG PHE A 234 50.347 71.301 79.688 1.00 34.93 A C
ATOM 754 CDl PHE A 234 50.890 71.281 78.368 1.00 35.46 A C
ATOM 755 CEl PHE A 234 52.248 70.693 78.117 1.00 36.67 A C
ATOM 756 CZ PHE A 234 52.921 70.104 79.207 1.00 36.48 A C
ATOM 757 CE2 PHE A 234 52.309 70.118 80.506 1.00 36.42 A C
ATOM 758 CD2 PHE A 234 51.055 70.684 80.720 1.00 35.14 A C
ATOM 759 C PHE A 234 49.617 74.072 78.906 1.00 29.85 A C
ATOM 760 O PHE A 234 50.610 74.783 78.929 1.00 29.29 A O
ATOM 761 N PHE A 235 48.882 74.025 77.843 1.00 31.52 A N
ATOM 762 CA PHE A 235 49.276 74.756 76.639 1.00 32.18 A C
ATOM 763 CB PHE A 235 48.284 74.429 75.551 1.00 35.65 A C
ATOM 764 CG PHE A 235 48.331 75.382 74.374 1.00 38.75 A C
ATOM 765 CDl PHE A 235 47.701 76.665 74.441 1.00 38.71 A C
ATOM 766 CEl PHE A 235 47.727 77.486 73.378 1.00 38.52 A C
ATOM 767 CZ PHE A 235 48.341 77.032 72.183 1.00 40.39 A C
ATOM 768 CE2 PHE A 235 48.983 75.783 72.094 1.00 39.24 A C
ATOM 769 CD2 PHE A 235 49.014 74.992 73.168 1.00 39.00 A C
ATOM 770 C PHE A 235 49.356 76.240 76.827 1.00 31.71 A C
ATOM 771 O PHE A 235 50.330 76.861 76.451 1.00 31.77 A O
ATOM 772 N HIS A 236 48.345 76.877 77.403 1.00 30.62 A N
ATOM 773 CA HIS A 236 48.543 78.302 77.709 1.00 29.30 A C
ATOM 774 CB HIS A 236 47.353 78.912 78.384 1.00 26.64 A C
ATOM 775 CG HIS A 236 46.124 78.789 77.575 1.00 26.12 A C
ATOM 776 NDl HIS A 236 45.970 79.417 76.369 1.00 26.58 A N ATOM 111 CEl HIS A 236 44.788 79.113 75.868 1.00 25.95 A C ATOM 778 NE2 HIS A 236 44.222 78.227 76.661 1.00 23.48 A N ATOM 779 CD2 HIS A 236 45.039 78.017 77.734 1.00 25.21 A C ATOM 780 C HIS A 236 49.771 78.603 78.534 1.00 28.80 A C ATOM 781 O HIS A 236 50.370 79.639 78.314 ,00 29.97 A O ATOM 782 N LEU A 237 50.172 77.742 79.452 ,00 27.65 A N ATOM 783 CA LEU A 237 51.224 78.097 80.411 ,00 28.55 A C ATOM 784 CB LEU A 237 51.208 77.210 81.661 .00 27.11 A C ATOM 785 CG LEU A 237 52.297 77.390 82.748 ,00 26.64 A C ATOM 786 CDl LEU A 237 52.590 78.827 83.239 .00 24.71 A C ATOM 787 CD2 LEU A 237 51.961 76.506 84.060 .00 26.51 A C ATOM 788 C LEU A 237 52.497 77.833 79.752 .00 30.87 A C ATOM 789 O LEU A 237 53.448 78.499 79.991 .00 29.96 A O ATOM 790 N SER A 238 52.507 76.711 78.999 .00 34.33 A N ATOM 791 CA SER A 238 53.628 76.266 78.146 1.00 34.93 A C ATOM 792 CB SER A 238 53.306 74.929 77.544 ,00 35.52 A C ATOM 793 OG SER A 238 53.122 74.008 78.653 .00 37.87 A O ATOM 794 C SER A 238 53.920 77.223 77.034 .00 35.82 A C ATOM 795 O SER A 238 55.066 77.192 76.588 .00 36.27 A O ATOM 796 N ARG A 239 52.967 78.115 76.659 ,00 34.92 A N ATOM 797 CA ARG A 239 53.221 79.079 75.619 .00 34.97 A C ATOM 798 CB ARG A 239 52.001 79.210 74.703 .00 35.93 A C ATOM 799 CG ARG A 239 51.597 77.874 74.092 .00 38.49 A C ATOM 800 CD ARG A 239 51.313 77.855 72.554 1.00 41.10 A C ATOM 801 NE ARG A 239 50.829 79.146 72.055 1.00 43.94 A N ATOM 802 CZ ARG A 239 50.667 79.411 70.760 1.00 46.05 A C ATOM 803 NHl ARG A 239 50.890 78.442 69.859 1.00 46.02 A N ATOM 804 NH2 ARG A 239 50.256 80.636 70.371 1.00 47.17 A N ATOM 805 C ARG A 239 53.613 80.418 76.141 .00 34.07 A C ATOM 806 O ARG A 239 54.085 81.280 75.457 ,00 34.50 A O ATOM 807 N GLU A 240 53.291 80.672 77.360 .00 34.17 A N ATOM 808 CA GLU A 240 53.449 81.947 77.921 .00 32.64 A C ATOM 809 CB GLU A 240 52.059 82.277 78.469 ,00 34.85 A C ATOM 810 CG GLU A 240 51.331 83.436 77.736 1.00 37.65 A C ATOM 811 CD GLU A 240 51.134 84.629 78.679 1.00 39.55 A C ATOM 812 OEl GLU A 240 51.133 85.818 78.263 1.00 39.97 A O ATOM 813 OE2 GLU A 240 50.998 84.315 79.914 1.00 42.12 A O ATOM 814 C GLU A 240 54.571 81.830 79.022 1.00 32.02 A C ATOM 815 O GLU A 240 55.105 82.877 79.481 1.00 30.94 A O ATOM 816 N ARG A 241 54.929 80.562 79.365 1.00 30.05 A N ATOM 817 CA ARG A 241 55.934 80.152 80.283 1.00 28.72 A C ATOM 818 CB ARG A 241 57.300 80.727 79.812 .00 30.98 A C ATOM 819 CG ARG A 241 57.657 80.617 78.246 .00 32.75 A C ATOM 820 CD ARG A 241 58.096 79.237 77.710 .00 34.25 A C ATOM 821 NE ARG A 241 57.426 78.113 78.410 .00 35.42 A N ATOM 822 CZ ARG A 241 57.438 76.806 78.088 ,00 36.84 A C ATOM 823 NHl ARG A 241 57.962 76.307 76.947 .00 37.36 A N ATOM 824 NH2 ARG A 241 56.804 75.976 78.901 .00 36.33 A N ATOM 825 C ARG A 241 55.605 80.388 81.826 .00 27.91 A C ATOM 826 O ARG A 241 55.739 79.498 82.664 .00 28.65 A O ATOM 827 N VAL A 242 55.242 81.622 82.163 .00 26.55 A N ATOM 828 CA VAL A 242 54.774 82.070 83.488 .00 24.80 A C ATOM 829 CB VAL A 242 55.796 83.013 84.104 .00 25.37 A C ATOM 830 CGl VAL A 242 55.712 83.034 85.561 ,00 25.22 A C ATOM 831 CG2 VAL A 242 57.120 82.411 83.837 .00 29.43 A C ATOM 832 C VAL A 242 53.497 82.890 83.231 1.00 22.45 A C ATOM 833 O VAL A 242 53.316 83.427 82.194 1.00 22.31 A O ATOM 834 N PHE A 243 52.596 82.815 84.161 1.00 20.65 A N ATOM 835 CA PHE A 243 51.403 83.526 84.262 1.00 17.60 A C ATOM 836 CB PHE A 243 50.283 82.567 84.818 1.00 16.83 A C ATOM 837 CG PHE A 243 49.575 81.788 83.758 .00 14.72 A C ATOM 838 CDl PHE A 243 49.838 82.030 82.409 ,00 14.06 A C ATOM 839 CEl PHE A 243 49.279 81.303 81.459 .00 13.71 A C ATOM 840 CZ PHE A 243 48.365 80.275 81.844 .00 15.27 A C ATOM 841 CE2 PHE A 243 48.094 80.025 83.178 .00 15.56 A C ATOM 842 CD2 PHE A 243 48.748 80.754 84.090 ,00 14.09 A C ATOM 843 C PHE A 243 51.721 84.585 85.279 ,00 17.87 A C ATOM 844 O PHE A 243 52.531 84.360 86.165 ,00 17.41 A O ATOM 845 N SER A 244 51.096 85.743 85.178 ,00 17.46 A N ATOM 846 CA SER A 244 51.322 86.780 86.219 1.00 17.46 A C ATOM 847 CB SER A 244 50.825 88.087 85.721 1.00 18.16 A C ATOM 848 OG SER A 244 49.476 87.918 85.623 1.00 21.13 A O ATOM 849 C SER A 244 50.567 86.357 87.531 1.00 17.83 A C ATOM 850 O SER A 244 49.638 85.394 87.476 1.00 18.18 A O
ATOM 851 N GLU A 245 50.976 86.966 88.642 1.00 15.80 A N
ATOM 852 CA GLU A 245 50.461 86.644 89.924 1.00 17.93 A C
ATOM 853 CB GLU A 245 51.076 87.470 91.052 1.00 17.50 A C
ATOM 854 CG GLU A 245 52.578 87.282 91.160 1.00 21.29 A C
ATOM 855 CD GLU A 245 53.193 87.529 92.531 1.00 24.08 A C
ATOM 856 OEl GLU A 245 54.494 87.566 92.577 1.00 27.58 A O
ATOM 857 OE2 GLU A 245 52.440 87.613 93.552 1.00 22.23 A O
ATOM 858 C GLU A 245 48.977 86.871 89.906 1.00 19.07 A C
ATOM 859 O GLU A 245 48.258 86.115 90.500 1.00 18.79 A O
ATOM 860 N ASP A 246 48.557 87.885 89.137 1.00 20.21 A N
ATOM 861 CA ASP A 246 47.160 88.194 89.023 1.00 22.06 A C
ATOM 862 CB ASP A 246 47.074 89.542 88.429 1.00 24.42 A C
ATOM 863 CG ASP A 246 45.800 90.237 88.753 1.00 28.29 A C
ATOM 864 ODl ASP A 246 45.246 90.236 89.941 1.00 30.03 A O
ATOM 865 OD2 ASP A 246 45.272 90.850 87.786 1.00 31.64 A O
ATOM 866 C ASP A 246 46.249 87.219 88.229 1.00 22.62 A C
ATOM 867 O ASP A 246 45.064 87.028 88.596 1.00 22.21 A O
ATOM 868 N ARG A 247 46.804 86.743 87.099 1.00 21.84 A N
ATOM 869 CA ARG A 247 46.232 85.691 86.310 1.00 21.25 A C
ATOM 870 CB ARG A 247 47.130 85.267 85.124 1.00 22.98 A C
ATOM 871 CG ARG A 247 46.641 85.586 83.766 1.00 25.12 A C
ATOM 872 CD ARG A 247 46.227 84.382 82.867 1.00 27.49 A C
ATOM 873 NE ARG A 247 47.008 84.371 81.663 1.00 29.04 A N
ATOM 874 CZ ARG A 247 46.814 83.543 80.683 1.00 29.59 A C
ATOM 875 NHl ARG A 247 45.851 82.664 80.724 1.00 29.84 A N
ATOM 876 NH2 ARG A 247 47.638 83.549 79.646 1.00 31.24 A N
ATOM 877 C ARG A 247 46.049 84.457 87.192 1.00 19.24 A C
ATOM 878 O ARG A 247 45.049 83.774 87.186 1.00 18.46 A O
ATOM 879 N THR A 248 47.121 84.173 87.886 1.00 18.00 A N
ATOM 880 CA THR A 248 47.106 83.055 88.764 1.00 15.55 A C
ATOM 881 CB THR A 248 48.530 82.823 89.295 1.00 15.79 A C
ATOM 882 OGl THR A 248 49.410 82.569 88.187 1.00 10.49 A O
ATOM 883 CG2 THR A 248 48.557 81.597 90.192 1.00 12.10 A C
ATOM 884 C THR A 248 46.096 83.205 89.881 1.00 14.18 A C
ATOM 885 O THR A 248 45.410 82.295 90.138 1.00 17.26 A O
ATOM 886 N ARG A 249 46.026 84.349 90.520 1.00 12.01 A N
ATOM 887 CA ARG A 249 44.980 84.613 91.467 1.00 12.07 A C
ATOM 888 CB ARG A 249 45.115 85.997 92.090 1.00 10.04 A C
ATOM 889 CG ARG A 249 43.889 86.660 92.805 1.00 11.93 A C
ATOM 890 CD ARG A 249 44.233 87.852 93.855 1.00 11.04 A C
ATOM 891 NE ARG A 249 45.227 88.593 93.302 1.00 16.21 A N
ATOM 892 CZ ARG A 249 46.512 88.735 93.617 1.00 15.62 A C
ATOM 893 NHl ARG A 249 47.064 88.459 94.708 1.00 13.97 A N
ATOM 894 NH2 ARG A 249 47.216 89.379 92.762 1.00 19.02 A N
ATOM 895 C ARG A 249 43.517 84.330 90.952 1.00 10.82 A C
ATOM 896 O ARG A 249 42.644 83.983 91.748 1.00 11.75 A O
ATOM 897 N PHE A 250 43.252 84.618 89.722 1.00 11.76 A N
ATOM 898 CA PHE A 250 41.933 84.540 89.118 1.00 11.61 A C
ATOM 899 CB PHE A 250 41.960 85.297 87.739 1.00 14.07 A C
ATOM 900 CG PHE A 250 40.748 85.159 86.981 1.00 14.07 A C
ATOM 901 CDl PHE A 250 39.660 86.034 87.212 1.00 14.95 A C
ATOM 902 CEl PHE A 250 38.336 85.748 86.555 1.00 13.55 A C
ATOM 903 CZ PHE A 250 38.209 84.728 85.707 1.00 12.71 A C
ATOM 904 CE2 PHE A 250 39.288 83.858 85.510 1.00 12.86 A C
ATOM 905 CD2 PHE A 250 40.604 84.096 86.120 1.00 13.06 A C
ATOM 906 C PHE A 250 41.615 83.040 88.965 1.00 13.68 A C
ATOM 907 O PHE A 250 40.546 82.583 89.391 1.00 14.28 A O
ATOM 908 N TYR A 251 42.535 82.257 88.452 1.00 13.63 A N
ATOM 909 CA TYR A 251 42.348 80.855 88.239 1.00 13.95 A C
ATOM 910 CB TYR A 251 43.536 80.294 87.449 1.00 14.52 A C
ATOM 911 CG TYR A 251 43.642 80.764 86.020 1.00 16.29 A C
ATOM 912 CDl TYR A 251 42.526 81.135 85.305 1.00 16.53 A C
ATOM 913 CEl TYR A 251 42.576 81.562 84.067 1.00 16.46 A C
ATOM 914 CZ TYR A 251 43.699 81.713 83.398 1.00 14.68 A C
ATOM 915 OH TYR A 251 43.650 82.137 82.071 1.00 15.96 A O
ATOM 916 CE2 TYR A 251 44.881 81.425 84.038 1.00 16.89 A C
ATOM 917 CD2 TYR A 251 44.865 80.886 85.370 1.00 16.16 A C
ATOM 918 C TYR A 251 42.230 80.180 89.565 1.00 14.23 A C
ATOM 919 O TYR A 251 41.400 79.361 89.845 1.00 14.40 A O
ATOM 920 N GLY A 252 43.119 80.522 90.412 1.00 14.21 A N
ATOM 921 CA GLY A 252 43.095 79.911 91.725 1.00 12.03 A C
ATOM 922 C GLY A 252 41.919 80.215 92.528 1.00 11.30 A C 26569
ATOM 923 O GLY A 252 41.430 79.297 93.185 00 12.29 A O
ATOM 924 N ALA A 253 41.428 81.495 92.466 00 10.19 A N
ATOM 925 CA ALA A 253 40.150 81.791 93.142 00 10.44 A C
ATOM 926 CB ALA A 253 39.845 83.148 92.951 00 11.06 A C
ATOM 927 C ALA A 253 38.964 80.878 92.672 00 10.74 A C
ATOM 928 O ALA A 253 38.261 80.312 93.471 00 10.73 A O
ATOM 929 N GLU A 254 38.917 80.635 91.351 00 11.97 A N
ATOM 930 CA GLU A 254 38.041 79.784 90.739 11.41 A C
ATOM 931 CB GLU A 254 38.027 79.951 89.240 8.04 A C
ATOM 932 CG GLU A 254 37.579 81.365 88.952 10.42 A C
ATOM 933 CD GLU A 254 37.019 81.579 87.514 15.15 A C
ATOM 934 OEl GLU A 254 37.354 80.841 86.627 12.07 A O
ATOM 935 OE2 GLU A 254 36.258 82.533 87.172 17.63 A O
ATOM 936 C GLU A 254 38.139 78.410 91.227 00 14.23 A C
ATOM 937 O GLU A 254 37.082 77.758 91.530 00 15.03 A O
ATOM 938 N ILE A 255 39.357 77.951 91.372 00 15.07 A N
ATOM 939 CA ILE A 255 39.552 76.637 91.761 00 13.72 A C
ATOM 940 CB ILE A 255 41.044 76.216 91.566 00 16.66 A C
ATOM 941 CGl ILE A 255 41.383 76.086 90.090 00 15.67 A C
ATOM 942 CDl ILE A 255 42.844 76.052 89.798 1.00 12.21 A C
ATOM 943 CG2 ILE A 255 41.337 74.914 92.244 1.00 16,40 A C
ATOM 944 C ILE A 255 39.167 76.406 93.185 1.00 14.15 A C
ATOM 945 O ILE A 255 38.682 75.375 93.524 1.00 17.05 A O
ATOM 946 N VAL A 256 39.409 77.420 93.998 1.00 15.73 A H
ATOM 947 CA VAL A 256 39.006 77.371 95.392 1.00 13.89 A C
ATOM 948 CB VAL A 256 39.467 78.576 96.149 00 13.51 A C
ATOM 949 CGl VAL A 256 38.890 78.730 97.713 00 9.71 A C
ATOM 950 CG2 VAL A 256 41.040 78.579 96.153 1.00 11.37 A C
ATOM 951 C VAL A 256 37.542 77.267 95.563 1.00 15.15 A C
ATOM 952 O VAL A 256 37.115 76.729 96.456 1.00 17.01 A O
ATOM 953 N SER A 257 36.803 77.859 94.646 1.0 000 1177..4444 A N
ATOM 954 CA SER A 257 35.356 78.084 94.792 1.0000 1155..8844 A C
ATOM 955 CB SER A 257 34.827 79.061 93.733 1.0000 1155..6633 A C
ATOM 956 OG SER A 257 33.357 79.246 93.814 1.00 88..0033 A O
ATOM 957 C SER A 257 34.923 76.613 94.587 1.00 18.12 A C
ATOM 958 O SER A 257 34.356 76.044 95.500 1.00 16.89 A O
ATOM 959 N ALA A 258 35.427 76.005 93.515 1.00 17.35 A N
ATOM 960 CA ALA A 258 34.944 74.703 93.153 1.00 18.65 A C
ATOM 961 CB ALA A 258 35.493 74.133 91.826 00 17.31 A C
ATOM 962 C ALA A' 258 35.229 73.795 94.249 1.00 18.77 A C
ATOM 963 O ALA A 258 34.460 72.986 94.596 1.00 20.07 A O
ATOM 964 N LEU A' 259 36.372 73.945 94.801 1.00 19.78 A N
ATOM 965 CA LEU A 259 36.798 72.996 95.770 1.00 19.81 A C
ATOM 966 CB LEU A 259 38.300 73.092 95.930 1.00 20.62 A C
ATOM 967 CG LEU A 259 39.204 72.564 94.837 1.00 20.40 A C
ATOM 968 CDl LEU A 259 40.684 72.644 95.201 1. 0000 2 200..82 A C
ATOM 969 CD2 LEU A 259 38.900 71.080 94.604 1.0000 2 222..84 A C
ATOM 970 C LEU A 259 36.023 73.215 97.131 1.00 19.42 A C
ATOM 971 O LEU A 259 35.747 72.293 97.815 1.00 19.78 A O
ATOM 972 N ASP A 260 35.760 74.431 97.500 1.00 20.19 A N
ATOM 973 CA ASP A 260 34.822 74.711 98.535 1.00 20.46 A C
ATOM 974 CB ASP A 260 34.479 76.260 98.584 1.00 19.98 A C
ATOM 975 CG ASP A 260 33.891 76.683 99.903 1.00 19.18 A C
ATOM 976 ODl ASP A 260 33.422 77.774 100.083 1.00 18.58 A O
ATOM 977 OD2 ASP A 260 33.964 75.935 100.850 1.00 18.70 A O
ATOM 978 C ASP A 260 33.443 73.949 98.407 1.00 22.14 A C
ATOM 979 O ASP A 260 32.941 73.336 99.389 1.00 22.81 A O
ATOM 980 N TYR A 261 32.883 73..988 97.185 1.00 21.27 A N
ATOM 981 CA TYR A 261 31.709 73.276 96.924 1.00 21.60 A C
ATOM 982 CB TYR A 261 31.330 73.573 95.499 1.00 21.00 A C
ATOM 983 CG TYR A 261 30.226 72.670 95.009 1.00 20.65 A C
ATOM 984 CDl TYR A 261 28.845 72.874 95.334 1.00 19.49 A C
ATOM 985 CEl TYR A 261 27.864 72.043 94.859 1.00 18.70 A C
ATOM 986 CZ TYR A 261 28.222 71.046 93.984 1.00 21.47 A C
ATOM 987 OH TYR A 261 27.426 70.097 93.444 1.00 22 .19 A O
ATOM 988 CE2 TYR A 261 29.519 70.833 93.643 1.00 21.40 A C
ATOM 989 CD2 TYR A 261 30.541 71.637 94.224 1.00 21.05 A C
ATOM 990 C TYR A 261 31.907 71.748 97.110 1.00 22 .80 A C
ATOM 991 O TYR A 261 31.094 71.103 97.660 1.00 22 .75 A O
ATOM 992 N LEU A 262 33.014 71.177 96.696 1.00 23 .51 A N
ATOM 993 CA LEU A 262 33.182 69.730 96.809 1.00 25 .11 A C
ATOM 994 CB LEU A 262 34.352 69.253 95.977 1.00 25 .55 A C
ATOM 995 CG LEU A 262 34.071 68.768 94.521 1.00 27.14 A C ATOM 996 CDl LEU A 262 33.160 69.512 93-885 28.50 A C
ATOM 997 CD2 LEU A 262 35.286 68.706 93-675 27.63 A C
ATOM 998 C LEU A 262 33.283 69.227 98-259 25.30 A C
ATOM 999 O LEU A 262 32.550 68.328 98-669 26.05 A O
ATOM 1000 N HIS A 263 34.188 69.841 99.012 24.64 A N
ATOM 1001 CA HIS A 263 34.330 69.632 100 -403 23.67 A C
ATOM 1002 CB HIS A 263 35.419 70.535 lOX-007 19.71 A C
ATOM 1003 CG HIS A 263 36.747 70.346 100-349 16.65 A C
ATOM 1004 NDl HIS A 263 37.815 71.196 1OO -522 14.80 A N
ATOM 1005 CEl HIS A 263 38.840 70.710 93-857 14.56 A C
ATOM 1006 NE2 HIS A 263 38.469 69.609 99.246 1.00 12.20 A N
ATOM 1007 CD2 HIS A 263 37.194 69.315 99.600 13.15 A C
ATOM 1008 C HIS A 263 33.017 69.8S5 101-127 24.92 A C
ATOM 1009 O HIS A 263 32.693 69.111 102 -022 26.69 A O
ATOM 1010 N SER A 264 32.243 70.887 10O-760 25.79 A N
ATOM 1011 CA SER A 264 31.011 71.061 101-517 26.57 A C
ATOM 1012 CB SER A 264 30.334 72.314 101-212 25.86 A C
ATOM 1013 OG SER A 264 30.086 72.161 93.806 33.09 A O
ATOM 1014 C SER A 264 30.069 69.850 101.227 26.86 A C
ATOM 1015 O SER A 264 29.212 69.604 101.997 28.29 A O
ATOM 1016 N GLY A 265 30.275 69.115 100.144 26.03 A N
ATOM 1017 CA GLY A 265 29.581 67.874 99.868 24.19 A C
ATOM 1018 C GLY A 265 30.298 66.710 100.398 25.16 A C
ATOM 1019 O GLY A 265 29.884 65.637 100.242 26.53 A O
ATOM 1020 N LYS A 266 31.461 66.895 101.026 24.77 A N
ATOM 1021 CA LYS A 266 32.316 65.805 101.463 1.00 23.63 A C
ATOM 1022 CB LYS A 266 31.543 64.789 102.390 26.54 A C
ATOM 1023 CG LYS A 266 31.163 65.371 103.817 27.26 A C
ATOM 1024 CD LYS A 266 29.732 65.794 103.842 30.04 A C
ATOM 1025 CE LYS A 266 28.850 65.053 104.855 32.52 A C
ATOM 1026 NZ LYS A 266 29.376 65.142 106.165 31.39 A N
ATOM 1027 C LYS A 266 33.057 65.064 100.382 22.39 A C
ATOM 1028 O LYS A 2S6 33.558 63.975 100.681 20.73 A O
ATOM 1029 N ILE A 267 33.213 65.673 99.189 22.38 A N
ATOM 1030 CA ILE A 267 33.961 65.082 98.096 22.16 A C
ATOM 1031 CB ILE A 267 33.393 65.475 96.763 24.13 A C
ATOM 1032 CGl ILE A 267 31.884 65.074 96.612 24.05 A C
ATOM 1033 CDl ILE A 267 31.735 63.732 96.946 1.00 27.73 A C
ATOM 1034 CG2 ILE A 267 34.208 64.840 95.569 22.93 A C
ATOM 1035 C ILE A 267 35.389 65.607 98.232 22.62 A C
ATOM 1036 O ILE A 267 35.626 66.822 98.506 23.46 A O
ATOM 1037 N VAL A 268 36.343 64.677 98.140 21.78 A N
ATOM 1038 CA VAL A 268 37.737 65.002 97.976 20.82 A C
ATOM 1039 CB VAL A 268 38.609 64.084 98.798 1.00 20.07 A C
ATOM 1040 CGl VAL A 268 40.068 64.496 98.689 .00 21.45 A C
ATOM 1041 CG2 VAL A 268 38.223 64.135 1O0.232 .00 17.76 A C
ATOM 1042 C VAL A 268 38.015 64.808 96.473 .00 21.47 A C
ATOM 1043 O VAL A 268 37.651 63.758 95.958 .00 22.03 A O
ATOM 1044 N TYR A 269 38.578 65.833 95.792 .00 20.90 A N
ATOM 1045 CA TYR A 269 38.802 65.785 94.319 .00 20.52 A C
ATOM 1046 CB TYR A 269 39.129 67.174 93.673 .00 17.28 A C
ATOM 1047 CG TYR A 269 39.179 67.095 92.175 ,00 18.77 A C
ATOM 1048 CDl TYR A 269 38.116 66.637 91.473 .00 20.66 A C
ATOM 1049 CEl TYR A 269 38.120 66.609 90.054 .00 19.11 A C
ATOM 1050 CZ TYR A 269 39.212 66.909 89.423 .00 19.08 A C
ATOM 1051 OH TYR A 269 39.155 66.774 87.969 .00 21.98 A O
ATOM 1052 CE2 TYR A 269 40.237 67.281 90.186 .00 19.00 A C
ATOM 1053 CD2 TYR A 269 40.189 67.444 91.492 .00 18.30 A C
ATOM 1054 C TYR A 269 39.879 64.823 93.932 .00 20.94 A C
ATOM 1055 O TYR A 269 39.833 64.223 92.908 .00 21.09 A O
ATOM 1056 N ARG A 270 40.888 64.754 94.745 .00 22.22 A N
ATOM 1057 CA ARG A 270 42.087 64.021 94.434 .00 24.53 A C
ATOM 1058 CB ARG A 270 41.836 62.545 34.624 .00 26.45 A C
ATOM 1059 CG ARG A 270 41.248 62.345 95.919 ,00 30.25 A C
ATOM 1060 CD ARG A 270 41.447 60.976 36.459 .00 33.82 A C
ATOM 1061 NE ARG A 270 40.775 59.958 35.653 .00 35.79 A N
ATOM 1062 CZ ARG A 270 40.958 58.617 35.790 .00 35.79 A C
ATOM 1063 NHl ARG A 270 41.799 58.151 36.709 .00 34.82 A N
ATOM 1064 NH2 ARG A 270 40.331 57.755 34.953 ,00 35.83 A N
ATOM 1065 C ARG A 270 42.854 64.299 93.140 ,00 23.89 A C
ATOM 1066 O ARG A 270 44.051 64.189 93.204 ,00 23.98 A O
ATOM 1067 N ASP A 271 42.188 64.669 32.017 ,00 23.79 A N
ATOM 1068 CA ASP A 271 42.839 64.760 SO.720 1.00 25.23 A C 2004/026569
ATOM 1069 CB ASP A 271 41.965 64.227 89.653 1.00 28.10 A C
ATOM 1070 CG ASP A 271 41.595 62.780 89.874 1.00 32.09 A C
ATOM 1071 ODl ASP A 271 40.499 62.351 89.504 1.00 35.54 A O
ATOM 1072 OD2 ASP A 271 42.421 62.001 90.409 1.00 31.75 A O
ATOM 1073 C ASP A 271 43.243 66.147 90.298 1.00 26.23 A C
ATOM 1074 O ASP A 271 43.529 66.335 89.145 1.00 25.93 A O
ATOM 1075 N LEU A 272 43.315 67.124 91.198 1.00 24.43 A N
ATOM 1076 CA LEU A 272 43.787 68.374 90.792 1.00 24.36 A C
ATOM 1077 CB LEU A 272 43.650 69.326 91.919 1.00 24.41 A C
ATOM 1078 CG LEU A 272 43.930 70.817 91.628 1.00 22.10 A C
ATOM 1079 CDl LEU A 272 43.251 71.186 90.342 1.00 23.78 A C
ATOM 1080 CD2 LEU A 272 43.439 71.658 92.689 1.00 20.92 A C
ATOM 1081 C LEU A 272 45.299 68.444 90.357 1.00 24.36 A C
ATOM 1082 O LEU A 272 46.202 68.249 91.128 1.00 23.73 A O
ATOM 1083 N LYS A 273 45.475 68.842 89.100 1.00 25.06 A N
ATOM 1084 CA LYS A 273 46.686 69.066 88.450 1.00 24.43 A C
ATOM 1085 CB LYS A 273 47.266 67.768 87.949 1.00 23.93 A C
ATOM 1086 CG LYS A 273 46.380 66.939 86.964 1.00 25.73 A C
ATOM 1087 CD LYS A 273 46.956 65.471 86.954 1.00 27.57 A C
ATOM 1088 CE LYS A 273 46.285 64.682 85.907 1.00 29.88 A C
ATOM 1089 NZ LYS A 273 46.618 63.234 85.941 1.00 32.66 A N
ATOM 1090 C LYS A 273 46.402 69.889 87.202 1.00 24.33 A C
ATOM 1091 O IiYS A 273 45.402 69.819 86.640 1.00 24.26 A O
ATOM 1092 N LEU A 274 47.435 70.511 86.672 1.00 24.62 A N
ATOM 1093 CA LEU A 274 47.368 71.332 85.472 1.00 24.96 A C
ATOM 1094 CB LEU A 274 48.837 71.695 85.212 1.00 24.41 A C
ATOM 1095 CG LEU A 274 48.952 72.759 84.129 1.00 24.32 A C
ATOM 1096 CDl LEU A 274 48.154 73.982 84.597 1.00 23.95 A C
ATOM 1097 CD2 LEU A 274 50.522 73.121 83.795 1.00 26.43 A C
ATOM 1098 C LEU A 274 46.731 70.748 84.208 1.00 25.04 A C
ATOM 1099 O LEU A 274 46.125 71.467 83.416 1.00 24.04 A O
ATOM 1100 N GLU A 275 47.060 69.499 83.957 1.00 26.37 A N
ATOM 1101 CA GLU A 275 46.440 68.712 82.962 1.00 28.23 A C
ATOM 1102 CB GLU A 275 47.025 67.275 83.008 1.00 31.34 A C
ATOM 1103 CG GLU A 275 46.657 66.548 81.725 1.00 37.03 A C
ATOM 1104 CD GLU A 275 47.031 65.064 81.762 1.00 39.02 A C
ATOM 1105 OEl GLU A 275 48.234 64.767 81.466 1.00 41.07 A O
ATOM 1106 OE2 GLU A 275 46.094 64.255 82.065 1.00 39.13 A O
ATOM 1107 C GLU A 275 44.843 68.652 83.004 1.00 27.51 A C
ATOM 1108 O GLU A 275 44.189 68.579 81.962 1.00 26.57 A O
ATOM 1109 N ASN A 276 44.247 68.837 84.178 1.00 25.68 A N
ATOM 1110 CA ASN A 276 42.784 68.790 84.311 1.00 24.42 A C
ATOM 1111 CB ASN A 276 42.395 67.982 85.503 1.00 23.99 A C
ATOM 1112 CG ASN A 276 42.835 66.437 85.333 1.00 28.17 A C
ATOM 1113 ODl ASN A 276 42.922 65,942 84.216 1.00 27.23 A O
ATOM 1114 ND2 ASN A 276 43.003 65.716 86.447 1.00 28.04 A N
ATOM 1115 C ASN A 276 42.149 70.116 84.413 1.00 22.69 A C
ATOM 1116 O ASN A 276 40.996 70.130 84.747 1.00 22.94 A O
ATOM 1117 N LEU A 277 42.890 71.175 84.098 1.00 21.15 A N
ATOM 1118 CA LEU A in 42.377 72.494 83.964 1.00 18.72 A C
ATOM 1119 CB LEU A in 43.289 73.394 84.748 1.00 17.12 A C
ATOM 1120 CG LEU A 277 43.450 73.047 86.279 1.00 15.85 A C
ATOM 1121 CDl LEU A 277 44.420 73.936 86.810 1.00 11.41 A C
ATOM 1122 CD2 LEU A 277 42.103 73.393 86.869 1.00 15.51 A C
ATOM 1123 C LEU A 277 42.234 72.965 82.523 1.00 18.92 A C
ATOM 1124 O LEU A 277 43.150 72.952 81.738 1.00 17.62 A O
ATOM 1125 N MET A 278 41.034 73.389 82.196 1.00 19.95 A N
ATOM 1126 CA MET A 278 40.733 74.000 80.949 1.00 19.66 A C
ATOM 1127 CB MET A 278 39.702 73.109 80.233 1.00 22.54 A C
ATOM 1128 CG MET A 278 40.333 71.799 79.843 1.00 27.66 A C
ATOM 1129 SD MET A 278 39.634 71.029 78.526 1.00 33.85 A S
ATOM 1130 CE MET A 278 40.938 71.584 77.150 1.00 30.62 A C
ATOM 1131 C MET A 278 40.116 75.383 81.092 1.00 18.88 A C
ATOM 1132 O MET A 278 39.752 75.811 82.197 1.00 16.68 A O
ATOM 1133 N LEU A 279 39.989 76.061 79.936 1.00 17.88 A N
ATOM 1134 CA LEU A 279 39.304 77.366 79.871 1.00 18.81 A C
ATOM 1135 CB LEU A 279 40.174 78.433 79.310 1.00 17.82 A C
ATOM 1136 CG LEU A 279 41.489 78.594 80.052 1.00 19.24 A C
ATOM 1137 CDl LEU A 279 42.288 79.818 79.649 1.00 18.67 A C
ATOM 1138 CD2 LEU A 279 41.119 78.692 81.573 1.00 18.57 A C
ATOM 1139 C LEU A 279 38.055 77.186 79.004 1.00 19.83 A C
ATOM 1140 O LEU A 279 38.084 76.341 78.119 1.00 19.63 A O
ATOM 1141 N ASP A 280 36.959 77.823 79.410 1.00 20.54 A N ATOM 1142 CA ASP A 280 35.822 77.971 78.619 1.00 22.62 A C
ATOM 1143 CB ASP A 280 34.489 78.132 79.414 1.00 22.97 A C
ATOM 1144 CG ASP A 280 34.436 79.342 80.291 1.00 24.75 A C
ATOM 1145 ODl ASP A 280 34.987 80.408 80.044 1.00 28.79 A O
ATOM 1146 OD2 ASP A 280 33.910 79.348 81.353 1.00 26.10 A O
ATOM 1147 C ASP A 280 36.014 79.174 77.725 1.00 23.96 A C
ATOM 1148 O ASP A 280 36.983 79.901 77.778 1.00 24.76 A O
ATOM 1149 N LYS A 281 34.997 79.387 76.934 1.00 24.85 A N
ATOM 1150 CA LYS A 281 35.021 80.256 75.813 1.00 24.99 A C
ATOM 1151 CB LYS A 281 33.598 80.271 75.101 1.00 25.76 A C
ATOM 1152 CG LYS A 281 32.350 80.663 75.939 1.00 26.82 A C
ATOM 1153 CD LYS A 281 30.930 80.709 75.148 1.00 28.22 A C
ATOM 1154 CE LYS A 281 30.506 79.297 74.782 1.00 28.21 A C
ATOM 1155 NZ LYS A 281 30.585 78.921 73.292 1.00 31.35 A N
ATOM 1156 C LYS A 281 35.430 81.605 76.339 1.00 24.33 A C
ATOM 1157 O LYS A 281 36.050 82.406 75.565 1.00 24.75 A O
ATOM 1158 N ASP A 282 35.016 81.877 77.602 1.00 23.43 A N
ATOM 1159 CA ASP A 282 35.134 83.226 78.177 1.00 22.32 A C
ATOM 1160 CB ASP A 282 33.920 83.522 79.050 1.00 23.41 A C
ATOM 1161 CG ASP A 282 32.643 83.459 78.290 1.00 24.49 A C
ATOM 1162 ODl ASP A 282 31.978 82.421 78.237 1.00 25.16 A O
ATOM 1163 OD2 ASP A 282 32.135 84.401 77.735 1.00 24.35 A O
ATOM 1164 C ASP A 282 36.429 83.401 78.988 1.00 21.37 A C
ATOM 1165 O ASP A 282 36.639 84.478 79.557 1.00 21.36 A O
ATOM 1166 N GLY A 283 37.270 82.357 79.078 1.00 19.68 A N
ATOM 1167 CA GLY A 283 38.443 82.393 79.956 1.00 19.57 A C
ATOM 1168 C GLY A 283 38.240 81.982 81.427 1.00 19.88 A C
ATOM 1169 O GLY A 283 39.089 82.099 82.239 1.00 21.43 A O
ATOM 1170 N HIS A 284 37.166 81.292 81.739 1.00 19.53 A N
ATOM 1171 CA HIS A 284 36.997 80.803 83.138 1.00 18.51 A C
ATOM 1172 CB HIS A 284 35.491 80.877 83.564 1.00 16.24 A C
ATOM 1173 CG HIS A 284 34.990 82.269 83.777 1.00 16.16 A C
ATOM 1174 NDl HIS A 284 35.333 82.998 84.903 1.00 14.69 A N
ATOM 1175 CEl HIS A 284 34.698 84.174 84.836 1.00 16.28 A C
ATOM 1176 NE2 HIS A 284 34.081 84.282 83.671 1.00 17.36 A N
ATOM 1177 CD2 HIS A 284 34.194 83.080 83.011 1.00 15.96 A C
ATOM 1178 C HIS A 284 37.479 79.391 83.269 1.00 19.15 A C
ATOM 1179 O HIS A 284 37.404 78.613 82.324 1.00 20.28 A O
ATOM 1180 N ILE A 285 37.880 78.998 84.458 1.00 18.11 A N
ATOM 1181 CA ILE A 285 38.267 77.706 84.671 1.00 18.06 A C
ATOM 1182 CB ILE A 285 38.794 77.599 86.052 1.00 19.43 A C
ATOM 1183 CGl ILE A 285 40.242 78.112 86.105 1.00 17.45 A C
ATOM 1184 CDl ILE A 285 41.298 77.056 85.539 1.00 12.78 A C
ATOM 1185 CG2 ILE A 285 38.808 76.160 86.506 1.00 16.53 A C
ATOM 1186 C ILE A 285 37.138 76.715 84.501 1.00 19.85 A C
ATOM 1187 O ILE A 285 36.040 76.891 84.993 1.00 21.09 A O
ATOM 1188 N LYS A 286 37.557 75.560 84.078 1.00 20.27 A N
ATOM 1189 CA LYS A 286 36.731 74.429 84.005 1.00 20.31 A C
ATOM 1190 CB LYS A 286 36.081 74.333 82.583 1.00 21.27 A C
ATOM 1191 CG LYS A 286 34.587 74.150 82.761 1.00 21.08 A C
ATOM 1192 CD LYS A 286 33.790 75.367 82.808 1.00 24.23 A C
ATOM 1193 CE LYS A 286 32.312 75.101 82.381 1.00 23.72 A C
ATOM 1194 NZ LYS A 286 31.555 75.025 83.521 1.00 24,33 A N
ATOM 1195 C LYS A 286 37.569 73.237 84.368 1.00 20.23 A C
ATOM 1196 O LYS A 286 38.420 72.849 83.591 1.00 20.26 A O
ATOM 1197 N ILE A 287 37.345 72.684 85.555 1.00 21.70 A N
ATOM 1198 CA ILE A 287 38.007 71.440 85.940 1.00 24.76 A C
ATOM 1199 CB ILE A 287 37.899 71.173 87.510 1.00 24.16 A C
ATOM 1200 CGl ILE A 287 38.259 72.420 88.297 1.00 22.33 A C
ATOM 1201 CDl ILE A 287 38.405 72.251 89.717 1.00 21.15 A C
ATOM 1202 CG2 ILE A 287 38.810 70.013 88.022 1.00 23.61 A C
ATOM 1203 C ILE A 287 37.343 70.298 85.204 1.00 28.26 A C
ATOM 1204 O ILE A 287 36.097 70.207 85.157 1.00 27.56 A O
ATOM 1205 N THR A 288 38.176 69.410 84.645 1.00 32.25 A N
ATOM 1206 CA THR A 288 37.665 68.567 83.535 1.00 35.77 A C
ATOM 1207 CB THR A 288 38.393 68.740 82.308 1.00 34.92 A C
ATOM 1208 OGl THR A 288 38.268 70.122 81.983 1.00 34.56 A O
ATOM 1209 CG2 THR A 288 37.641 67.941 81.210 1.00 32.66 A C
ATOM 1210 C THR A 288 37.583 67.107 83.684 1.00 39.38 A C
ATOM 1211 O THR A 288 36.827 66.399 82.936 1.00 39.51 A O
ATOM 1212 N ASP A 289 38.331 66.584 84.577 1.00 42.93 A N
ATOM 1213 CA ASP A 289 37.975 65.209 84.893 1.00 46.24 A C
ATOM 1214 CB ASP A 289 36.388 64.937 84.944 1.00 45.46 A C ATOM 1215 CG ASP A 289 35.957 63.835 86.000 1.00 45.18 A C
ATOM 1216 ODl ASP A 289 35.855 62.624 85.584 1.00 44.99 A O
ATOM 1217 OD2 ASP A 289 35.630 64.063 87.191 1.00 42.76 A O
ATOM 1218 C ASP A 289 38.648 64.311 83.905 1.00 48.00 A C
ATOM 1219 O ASP A 289 38.995 64.692 82.787 1.00 46.27 A O
ATOM 1220 N PHE A 290 38.802 63.082 84.373 1.00 51.31 A N
ATOM 1221 CA PHE A 290 39.606 62.105 83.682 1.00 54.56 • A C
ATOM 1222 CB PHE A 290 38.682 61.469 82.628 1.00 55.41 A C
ATOM 1223 CG PHE A 290 37.258 61.124 83.122 1.00 55.40 A C
ATOM 1224 CDl PHE A 290 36.120 61.665 82.501 1.00 55.28 A C
ATOM 1225 CEl PHE A 290 34.832 61.374 82.949 1.00 55.02 A C
ATOM 1226 CZ PHE A 290 34.648 60.513 83.981 1.00 55.41 A C
ATOM 1227 CE2 PHE A 290 35.748 59.921 84.590 1.00 55.44 A C
ATOM 1228 CD2 PHE A 290 37.061 60.241 84.172 1.00 55.08 A C
ATOM 1229 C PHE A 290 40.872 62.870 83.064 1.00 56.69 A C
ATOM 1230 O PHE A 290 41.971 63.084 83.750 1.00 56.89 A O
ATOM 1231 N GLY A 291 40.698 63.371 81.828 1.00 58.55 A N
ATOM 1232 CA GLY A 291 41.811 63.987 81.100 1.00 60.43 A C
ATOM 1233 C GLY A 291 42.672 62.808 80.666 1.00 61.96 A C
ATOM 1234 O GLY A 291 43.046 62.017 81.494 1.00 61.79 A O
ATOM 1235 N LEU A 292 42.895 62.638 79.366 1.00 63.95 A N
ATOM 1236 CA LEU A 292 43.843 61.645 78.863 1.00 65.80 A C
ATOM 1237 CB LEU A 292 43.666 61.413 77.346 1.00 64.90 A C
ATOM 1238 CG LEU A 292 42.240 60.982 76.902 1.00 63.95 A C
ATOM 1239 CDl LEU A 292 42.086 60.534 75.398 1.00 62.43 A C
ATOM 1240 CD2 LEU A 292 41.744 59.921 77.840 1.00 64.13 A C
ATOM 1241 C LEU A 292 45.244 62.197 79.206 1.00 67.70 A C
ATOM 1242 O LEU A 292 45.351 63.298 79.845 1.00 68.40 A O
ATOM 1243 N CYS A 293 46.317 61.477 78.836 1.00 69.10 A N
ATOM 1244 CA CYS A 293 47.615 61.860 79.397 1.00 70.29 A C
ATOM 1245 CB CYS A 293 47.728 61.663 80.943 1.00 70.04 A C
ATOM 1246 SG CYS A 293 46.661 60.487 81.790 1.00 71.14 A S
ATOM 1247 C CYS A 293 48.927 61.414 78.803 1.00 70.94 A C
ATOM 1248 O CYS A 293 49.184 60.253 78.433 1.00 70.95 A O
ATOM 1249 N LYS A 294 49.759 62.442 78.872 1.00 71.56 A N
ATOM 1250 CA LYS A 294 51.144 62.500 78.493 1.00 71.92 A C
ATOM 1251 CB LYS A 294 51.997 63.001 79.651 1.00 71.85 A C
ATOM 1252 CG LYS A 294 51.772 64.477 79.907 1.00 71.44 A C
ATOM 1253 CD LYS A 294 52.349 65.391 78.822 1.00 70.59 A C
ATOM 1254 CE LYS A 294 53.894 65.439 78.836 1.00 70.18 A C
ATOM 1255 NZ LYS A 294 54.471 66.062 80.073 1.00 69.28 A N
ATOM 1256 C LYS A 294 51.725 61.265 77.904 1.00 72.40 A C
ATOM 1257 O LYS A 294 51.993 60.232 78.588 1.00 72.49 A O
ATOM 1258 N GLU A 295 51.887 61.434 76.585 1.00 72.54 A N
ATOM 1259 CA GLU A 295 52.671 60.573 75.711 1.00 72.21 A C
ATOM 1260 CB GLU A 295 51.806 59.434 75.148 1.00 71.42 A C
ATOM 1261 CG GLU A 295 51.682 58.221 76.075 1.00 70.48 A C
ATOM 1262 CD GLU A 295 51.023 57.011 75.405 1.00 69.71 A C
ATOM 1263 OEl GLU A 295 50.917 55.972 76.086 1.00 68.62 A O
ATOM 1264 OE2 GLU A 295 50.584 57.086 74.217 1.00 68.61 A O
ATOM 1265 C GLU A 295 53.211 61.496 74.603 1.00 72.60 A C
ATOM 1266 O GLU A 295 52.760 61.376 73.453 1.00 72.90 A O
ATOM 1267 N GLY A 296 54.191 62.371 74.941 1.00 72.73 A N
ATOM 1268 CA GLY A 296 54.607 63.485 74.065 1.00 73.30 A C
ATOM 1269 C GLY A 295 56.077 63.723 73.728 1.00 73.76 A C
ATOM 1270 O GLY A 296 56.418 63.925 72.540 1.00 73.69 A O
ATOM 1271 N LYS A 304 52.922 50.315 89.761 1.00 58.49 A N
ATOM 1272 CA LYS A 304 52.773 51.654 90.321 1.00 58.55 A C
ATOM 1273 CB LYS A 304 52.335 52.644 89.224 1.00 58.66 A C
ATOM 1274 CG LYS A 304 51.302 52.095 88.161 1.00 58.43 A C
ATOM 1275 CD LYS A 304 49.806 52.562 88.446 1.00 58.01 A C
ATOM 1276 CE LYS A 304 49.423 54.029 88.028 1.00 57.18 A C
ATOM 1277 NZ LYS A 304 47.951 54.389 88.386 1.00 55.65 A N
ATOM 1278 C LYS A 304 51.845 51.729 91.591 1.00 58.82 A C
ATOM 1279 O LYS A 304 52.332 52.139 92.649 1.00 58.68 A O
ATOM 1280 N THR A 305 50.554 51.309 91.508 1.00 59.05 A N
ATOM 1281 CA THR A 305 49.535 51.421 92.614 1.00 58.96 A C
ATOM 1282 CB THR A 305 49.906 50.471 93.808 1.00 58.14 A C
ATOM 1283 OGl THR A 305 50.924 51.054 94.630 1.00 57.81 A O
ATOM 1284 CG2 THR A 305 50.514 49.187 93.309 1.00 58.24 A C
ATOM 1285 C THR A 305 49.180 52.895 93.080 1.00 59.62 A C
ATOM 1286 O THR A 305 48.603 53.163 94.132 1.00 59.83 A O
ATOM 1287 N PHE A 306 49.550 53.843 92.236 1.00 60.19 A N ATOM 1288 CA PHE A 306 49.500 55.289 92.516 1.00 60.64 A C
ATOM 1289 CB PHE A 306 50.889 55.793 92.993 1.00 59.91 A C
ATOM 1290 CG PHE A 306 51.179 55.449 94.446 1.00 59.53 A C
ATOM 1291 CDl PHE A 306 51.466 54.110 94.830 1.00 59.88 A C
ATOM 1292 CEl PHE A 306 51.710 53.767 96.185 1.00 60.02 A C
ATOM 1293 CZ PHE A 306 51.674 54.795 97.151 1.00 60.05 A C
ATOM 1294 CE2 PHE A 306 51.395 56.086 96.765 1.00 59.42 A C
ATOM 1295 CD2 PHE A 306 51.126 56.410 95.424 1.00 58.78 A C
ATOM 1296 C PHE A 306 48.934 56.020 91.257 1.00 60.89 A C
ATOM 1297 O PHE A 306 49.678 56.548 90.386 1.00 60.77 A O
ATOM 1298 N CYS A 307 47.591 55.915 91.184 1.00 61.03 A N
ATOM 1299 CA CYS A 307 46.664 56.680 90.308 1.00 61.16 A C
ATOM 1300 CB CYS A 307 45.201 56.500 90.812 1.00 61.31 A C
ATOM 1301 SG CYS A 307 44.918 57.106 92.536 1.00 61,63 A S
ATOM 1302 C CYS A 307 46.981 58.168 90.294 1.00 60.78 A C
ATOM 1303 O CYS A 307 47.373 58.723 91.343 1.00 61.55 A O
ATOM 1304 N GIiY A 308 46.828 58.816 89.126 1.00 59.78 A N
ATOM 1305 CA GLY A 308 47.136 60.250 89.036 1.00 58.25 A C
ATOM 1306 C GIJY A 308 48.638 60.503 89.120 1.00 57.02 A C
ATOM 1307 O GLY A 308 49.423 59.581, 89.453 1.00 56.66 A O
ATOM 1308 N THR A 309 49.040 61.740 88.807 1.00 55.69 A N
ATOM 1309 CA THR A 309 50.415 61.946 88.364 1.00 54.26 A C
ATOM 1310 CB THR A 309 50.660 63.156 87.358 1.00 53.97 A C
ATOM 1311 OGl THR A 309 50.009 62.955 86.079 1.00 54.43 A O
ATOM 1312 CG2 THR A 309 52.105 63.202 86.940 1.00 54.39 A C
ATOM 1313 C THR A 309 51.261 62.061 89.597 1.00 52.93 A C
ATOM 1314 O THR A 309 50.824 62.641 90.588 1.00 52.74 A O
ATOM 1315 N PRO A 310 52.431 61.414 89.506 1.00 51.21 A N
ATOM 1316 CA PRO A 310 53.518 61.362 90.507 1.00 49.77 A C
ATOM 1317 CB PRO A 310 54.714 60.897 89.647 1.00 49.52 A C
ATOM 1318 CG PRO A 310 54.094 59.960 88.726 1.00 50.33 A C
ATOM 1319 CD PRO A 310 52.702 60.504 88.392 1.00 50.90 A C
ATOM 1320 C PRO A 310 53.948 62.614 91.289 1.00 47.55 A C
ATOM 1321 O PRO A 310 54.135 62.572 92.497 1.00 46.89 A O
ATOM 1322 N GLU A 311 54.167 63.677 90.536 1.00 46.40 A N
ATOM 1323 CA GLU A 311 54.775 64.968 90.972 1.00 44.83 A C
ATOM 1324 CB GLU A 311 55.223 65.770 89.727 1.00 45.41 A C
ATOM 1325 CG GLU A 311 56.331 65.149 88.805 1.00 46.28 A C
ATOM 1326 CD GLU A 311 55.945 63.924 87.879 1.00 47.10 A C
ATOM 1327 OEl GLU A 311 54.767 63.606 87.481 1.00 45.87 A O
ATOM 1328 OE2 GLU A 311 56.9-24 63.213 87.523 1.00 47.09 A O
ATOM 1329 C GLU A 311 53.731 65.784 91.781 1.00 43.57 A C
ATOM 1330 O GLU A 311 54.057 66.697 92.550 1.00 43.53 A O
ATOM 1331 N TYR A 312 52.475 65.364 91.627 1.00 41.18 A N
ATOM 1332 CA TYR A 312 51.359 65.980 92.268 1.00 39.39 A C
ATOM 1333 CB TYR A 312 50.151 65.984 91.267 1.00 37.78 A C
ATOM 1334 CG TYR A 312 50.254 67.050 90.150 1.00 37.07 A C
ATOM 1335 CDl TYR A 312 50.833 66.733 88.924 1.00 35.95 A C
ATOM 1336 CEl TYR A 312 50.961 67.698 87.928 1.00 35.48 A C
ATOM 1337 CZ TYR A 312 50.460 69.050 88.134 1.00 34.72 A C
ATOM 1338 OH TYR A 312 50.614 69.957 87.075 1.00 34.18 A O
ATOM 1339 CE2 TYR A 312 49.872 69.389 89.328 1.00 34.83 A C
ATOM 1340 CD2 TYR A 312 49.790 68.394 90.354 1.00 36.44 A C
ATOM 1341 C TYR A 312 51.013 65.286 93.600 1.00 38.51 A C
ATOM 1342 O TYR A 312 50.069 65.660 94.281 1.00 40.18 A O
ATOM 1343 N LEU A 313 51.730 64.280 94.004 1.00 36.11 A N
ATOM 1344 CA LEU A 313 51.279 63.504 95.156 1.00 34.67 A C
ATOM 1345 CB LEU A 313 51.828 62.028 95.126 1.00 34.17 A C
ATOM 1346 CG LEU A 313 51.346 61.115 93.967 1.00 34.16 A C
ATOM 1347 CDl LEU A 313 52.186 59.862 93.930 1.00 34.16 A C
ATOM 1348 CD2 LEU A 313 49.889 60.753 94.059 1.00 32.76 A C
ATOM 1349 C LEU A 313 51.708 64.102 96.440 1.00 32.74 A C
ATOM 1350 O LEU A 313 52.888 64.267 96.668 1.00 33.33 A O
ATOM 1351 N ALA A 314 50.759 64.320 97.320 1.00 30.49 A N
ATOM 1352 CA ALA A 314 51.015 64.855 98.622 1.00 29.23 A C
ATOM 1353 CB ALA A 314 49.639 65.274 99.211 1.00 28.99 A C
ATOM 1354 C ALA A 314 51.698 63.908 99.637 1.00 28.32 A C
ATOM 1355 O ALA A 314 51.461 62.657 99.661 1.00 26.76 A O
ATOM 1356 N PRO A 315 52.377 64.543 100.589 1.00 27.99 A N
ATOM 1357 CA PRO A 315 52.992 63.860 101.705 1.00 29.95 A C
ATOM 1358 CB PRO A 315 53.174 64.934 102.747 1.00 27.96 A C
ATOM 1359 CG PRO A 315 53.613 66.078 101.772 1.00 28.73 A C
ATOM 1360 CD PRO A 315 52.702 65.965 100.630 1.00 27.71 A C ATOM 1361 C PRO A 315 52.200 62.780 102.261 ,00 31.54 A C
ATOM 1362 O PRO A 315 52.751 61.670 102.279 ,00 32.28 A O
ATOM 1363 N GLU A 316 51.042 63.090 102.789 .00 32.87 A N
ATOM 1364 CA GLU A 316 50.270 62.091 103.504 .00 34.37 A C
ATOM 1365 CB GLU A 316 49.010 62.723 104.229 ,00 34.44 A C
ATOM 1366 CG GLU A 316 47.871 63.318 103.421 ,00 33.71 A C
ATOM 1367 CD GLU A 316 48.127 64.787 102.998 .00 33.66 A C
ATOM 1368 OEl GLU A 316 49.270 65.121 102.665 .00 30.79 A O
ATOM 1369 OE2 GLU A 316 47.132 65.576 102.940 .00 33.11 A O
ATOM 1370 C GLU A 316 49.897 60.913 102.587 .00 35.71 A C
ATOM 1371 O GLU A 316 49.846 59.723 103.083 .00 36.14 A O
ATOM 1372 N VAL A 317 49.596 61.217 101.301 1.00 35.95 A N
ATOM 1373 CA VAL A 317 49.363 60.151 100.324 .00 36.60 A C
ATOM 1374 CB VAL A 317 49.068 60.639 98.926 .00 37.51 A C
ATOM 1375 CGl VAL A 317 49.162 59.343 97.909 .00 36.92 A C
ATOM 1376 CG2 VAL A 317 Al.121 61.371 98.890 .00 35.46 A C
ATOM 1377 C VAL A 317 50.545 59.178 100.189 .00 36.14 A C
ATOM 1378 O VAL A 317 50.461 58.025 100.584 .00 36.90 A O
ATOM 1379 N LEU A 318 51.643 59.673 99.706 .00 37.37 A N
ATOM 1380 CA LEU A 318 52.881 58.972 99.746 .00 38.52 A C
ATOM 1381 CB LEU A 318 54.027 59.991 99.610 .00 38.54 A C
ATOM 1382 CG LEU A 318 54.124 60.836 98.319 .00 39.17 A C
ATOM 1383 CDl LEU A 318 55.558 61.372 98.052 .00 38.61 A C
ATOM 1384 CD2 LEU A 318 53.621 60.014 97.169 .00 39.22 A C
ATOM 1385 C LEU A 318 53.100 58.202 101.006 .00 40.48 A C
ATOM 1386 O LEU A 318 53.421 57.034 101.003 .00 41.64 A O
ATOM 1387 N GLU A 319 52.958 58.836 102.138 .00 41.46 A N
ATOM 1388 CA GLU A 319 53.328 58.171 103.369 .00 42.69 A C
ATOM 1389 CB GLU A 319 53.368 59.212 104.487 .00 42.95 A C
ATOM 1390 CG GLU A 319 54.697 59.556 105.162 .00 44.91 A C
ATOM 1391 CD GLU A 319 54.401 60.323 106.424 .00 46.65 A C
ATOM 1392 OEl GLU A 319 53.640 61.314 106.251 .00 47.53 A O
ATOM 1393 OE2 GLU A 319 54.844 59.958 107.568 1.00 47.49 A O
ATOM 1394 C GLU A 319 52.304 56.963 103.598 1.00 43.78 A C
ATOM 1395 O GLU A 319 52.134 56.006 102.733 1.00 43.35 A O
ATOM 1396 N ASP A 320 51.630 56.993 104.728 1.00 44.23 A N
ATOM 1397 CA ASP A 320 50.784 55.923 105.070 1.00 46.33 A C
ATOM 1398 CB ASP A 320 50.845 55.686 106.616 1.00 48.87 A C
ATOM 1399 CG ASP A 320 52.264 55.965 107.195 1.00 49.42 A C
ATOM 1400 ODl ASP A 320 53.229 55.933 106.316 49.95 A O
ATOM 1401 OD2 ASP A 320 52.461 56.261 108.449 48.12 A O
ATOM 1402 C ASP A 320 49.477 56.357 104.467 46.45 A C
ATOM 1403 O ASP A 320 49.524 56.839 103.352 46.13 A O
ATOM 1404 N ASN A 321 48.313 56.192 105.106 47.24 A N
ATOM 1405 CA ASN A 321 47.042 56.373 104.297 48.40 A C
ATOM 1406 CB ASN A 321 46.477 54.967 103.767 48.16 A C
ATOM 1407 CG ASN A 321 46.847 54.668 102.256 47.85 A C
ATOM 1408 ODl ASN A 321 48.036 54.647 101.833 46.95 A O
ATOM 1409 ND2 ASN A 321 45.815 54.395 101.472 47.39 A N
ATOM 1410 C ASN A 321 45.908 57.245 104.948 48.57 A C
ATOM 1411 O ASN A 321 44.688 56.913 104.881 48.51 A O
ATOM 1412 N ASP A 322 46.258 58.358 105.567 47.89 A N
ATOM 1413 CA ASP A 322 45.185 59.269 106.029 1.00 47.62 A C
ATOM 1414 CB ASP A 322 45.378 59.678 107.487 .00 48.87 A C
ATOM 1415 CG ASP A 322 45.084 58.565 108.427 .00 50.37 A C
ATOM 1416 ODl ASP A 322 45.420 58.769 109.634 .00 50.97 A O
ATOM 1417 0D2 ASP A 322 44.542 57.467 108.066 .00 51.08 A O
ATOM 1418 C ASP A 322 45.044 60.503 105.110 .00 45.97 A C
ATOM 1419 O ASP A 322 44.992 61.647 105.531 .00 46.39 A O
ATOM 1420 N TYR A 323 44.911 60.246 103.846 .00 44.27 A N
ATOM 1421 CA TYR A 323 44.485 61.288 102.955 .00 43.11 A C
ATOM 1422 CB TYR A 323 44.792 60.891 101.509 .00 45.80 A C
ATOM 1423 CG TYR A 323 44.238 59.571 100.992 .00 50.03 A C
ATOM 1424 CDl TYR A 323 44.786 59.018 99.809 .00 51.89 A C
ATOM 1425 CEl TYR A 323 44.298 57.765 99.256 1.00 52.49 A C
ATOM 1426 CZ TYR A 323 43.241 57.054 99.942 1.00 53.72 A C
ATOM 1427 OH TYR A 323 42.814 55.876 99.395 1.00 53.04 A O
ATOM 1428 CE2 TYR A 323 42.656 57.566 101.148 1.00 52.63 A C
ATOM 1429 CD2 TYR A 323 43.159 58.832 101.672 1.00 51.62 A C
ATOM 1430 C TYR A 323 42.986 61.719 103.163 1.00 40.89 A C
ATOM 1431 O TYR A 323 42.099 60.877 103.407 1.00 40.76 A O
ATOM 1432 N GLY A 324 42.765 63.042 103.114 1.00 37.41 A N
ATOM 1433 CA GLY A 324 41.472 63.663 102.909 1.00 33.59 A C ATOM 1434 C GLY A 324 41.541 64.995 102.119 1.00 31.56 A C
ATOM 1435 O GLY A 324 42.466 65.207 101.412 1.00 31.26 A O
ATOM 1436 N ARG A 325 40.558 65.870 102.337 1.00 28.53 A N
ATOM 1437 CA ARG A 325 40.332 67.105 101.634 1.00 25.63 A C
ATOM 1438 CB ARG A 325 39.186 67.915 102.286 1.00 24.39 A C
ATOM 1439 CG ARG A 325 39.359 68.259 103.785 1.00 25.14 A C
ATOM 1440 CD ARG A 325 38.171 68.968 104.463 00 23.38 A C
ATOM 1441 NE ARG A 325 38.381 69.215 105.904 00 24.04 A N
ATOM 1442 CZ ARG A 325 39.124 70.220 106.465 00 26.52 A C
ATOM 1443 NHl ARG A 325 39.707 71.147 105.710 00 28.14 A N
ATOM 1444 NH2 ARG A 325 39.309 70.318 107.836 00 28.08 A N
ATOM 1445 C ARG A 325 41.612 67.877 101.483 00 24.75 A C
ATOM 1446 O ARG A 325 41.811 68.566 100.519 00 22.72 A O
ATOM 1447 N ALA A 326 42.480 67.742 102.476 00 23.11 A N
ATOM 1448 CA ALA A 326 43.669 68.544 102.508 00 20.85 A C
ATOM 1449 CB ALA A 326 44.406 68.430 103.839 00 18.67 A C
ATOM 1450 C ALA A 326 44.566 68.255 101.404 00 19.33 A C
ATOM 1451 O ALA A 326 45.403 69.104 101.073 00 20.61 A O
ATOM 1452 N VAL A 327 44.399 67.129 100.761 00 20.65 A N
ATOM 1453 CA VAL A 327 45.186 66.819 99.581 00 19.26 A C
ATOM 1454 CB VAL A 327 44.938 65.425 99.024 00 20.18 A C
ATOM 1455 CGl VAL A 327 45.281 64.402 99.965 00 19.55 A C
ATOM 1456 CG2 VAL A 327 43.422 65.251 98.528 00- 20.30 A C
ATOM 1457 C VAL A 327 44.968 67.789 98.417 00 18.73 A C
ATOM 1458 O VAL A 327 45.932 68.133 97.644 00 17.98 A O
ATOM 1459 N ASP A 328 43.658 68.120 98.254 00 17.65 A N
ATOM 1460 CA ASP A 328 43.193 69.148 97.265 00 15.41 A C
ATOM 1461 CB ASP A 328 41.750 69.355 97.275 00 13.27 A C
ATOM 1462 CG ASP A 328 40.966 68.145 96.783 00 12.43 A C
ATOM 1463 ODl ASP A 328 41.553 67.340 96.010 1.00 9.36 A O
ATOM 1464 OD2 ASP A 328 39.775 67.951 97.049 .00 12.56 A O
ATOM 1465 C ASP A 328 43.946 70.454 97.508 .00 13.95 A C
ATOM 1466 O ASP A 328 44.428 71.007 96.500 .00 14.31 A O
ATOM 1467 N TRP A 329 44.207 70.837 98.741 .00 11.83 A N
ATOM 1468 CA TRP A 329 44.915 72.020 98.939 ,00 13.56 A C
ATOM 1469 CB TRP A 329 44.764 72.549 100.412 .00 15.57 A C
ATOM 1470 CG TRP A 329 43.424 72.713 100.824 1.00 16.10 A C
ATOM 1471 CDl TRP A 329 42.845 72.161 101.892 .00 16.38 A C
ATOM 1472 NEl TRP A 329 41.512 72.484 101.910 ,00 16.46 A N
ATOM 1473 CE2 TRP A 329 41.236 73.253 100.843 .00 14.45 A C
ATOM 1474 CD2 TRP A 329 42.387 73.347 100.097 ,00 15.75 A C
ATOM 1475 CE3 TRP A 329 42.345 74.041 98.877 .00 16.77 A C
ATOM 1476 CZ3 TRP A 329 41.196 74.572 98.466 ,00 19.05 A C
ATOM 1477 CH2 TRP A 329 40.034 74.396 99.197 .00 17.50 A C
ATOM 1478 CZ2 TRP A 329 40.064 73.775 100.444 .00 16.89 A C
ATOM 1479 C TRP A 329 46.401 71.882 98.605 1.00 13.15 A C
ATOM 1480 O TRP A 329 47.039 72.800 98.202 1.00 14.44 A O
ATOM 1481 N TRP A 330 47.005 70.726 98.871 00 14.09 A N
ATOM 1482 CA TRP A 330 48.360 70.516 98.435 00 13.30 A C
ATOM 1483 CB TRP A 330 48.745 69.086 98.770 00 14.91 A C
ATOM 1484 CG TRP A 330 50.005 68.664 98.131 00 15.71 A C
ATOM 1485 CDl TRP A 330 50.197 68.159 96.839 00 14.18 A C
ATOM 148S NEl TRP A 330 51.559 68.005 96.631 00 16.08 A N
ATOM 1487 CE2 TRP A 330 52.249 68.348 97.779 00 16.65 A C
ATOM 1488 CD2 TRP A 330 51.291 68.807 98.703 00 14.11 A C
ATOM 1489 CE3 TRP A 330 51.731 69.236 99.874 00 14.98 A C
ATOM 1490 CZ3 TRP A 330 53.201 69.244 100.145 00 15.66 A C
ATOM 1491 CH2 TRP A 330 54.108 68.871 99.220 00 13.33 A C
ATOM 1492 CZ2 TRP A 330 53.711 68.430 98.040 00 15.31 A C
ATOM 1493 C TRP A 330 48.367 70.704 96.862 00 14.52 A C
ATOM 1494 O TRP A 330 49.266 71.456 96.288 00 13.36 A O
ATOM 1495 N GLY A 331 47.362 70.081 96.169 00 12.84 A N
ATOM 1496 CA GLY A 331 47.317 70.132 94.727 00 11.57 A C
ATOM 1497 C GLY A 331 47.145 71.550 94.213 1.00 13.02 A C
ATOM 1498 O GLY A 331 47.787 71.927 93.148 1.00 14.38 A O
ATOM 1499 N LEU A 332 46.445 72.400 95.018 00 10.55 A N
ATOM 1500 CA LEU A 332 46.262 73.810 94.614 00 10.32 A C
ATOM 1501 CB LEU A 332 45.252 74.565 95.490 00 6.54 A C
ATOM 1502 CG LEU A 332 45.172 75.933 95.246 00 7.11 A C
ATOM 1503 CDl LEU A 332 44.668 76.162 93.877 00 9.33 A C
ATOM 1504 CD2 LEU A 332 44.243 76.623 96.214 00 6.28 A C
ATOM 1505 C LEU A 332 47.662 74.515 94.592 00 10.84 A C
ATOM 1506 O LEU A 332 47.993 75.231 93.720 1.00 12.25 A O 2004/026569
ATOM 1507 N GLY A 333 48.366 74.347 9S.652 1.00 10.60 A N
ATOM 1508 CA GLY A 333 49.749 74.586 95.736 1.00 10.26 A C
ATOM 1509 C GLY A 333 50.524 74.318 94.453 1.00 10.98 A C
ATOM 1510 O GLY A 333 51.048 75.212 93.844 1.00 12.02 A O
ATOM 1511 N VAL A 334 50.624 73.043 94.112 1.00 10.76 A N
ATOM 1512 CA VAL A 334 51.406 72.644 92.998 1.00 11.03 A C
ATOM 1513 CB VAL A 334 51.284 71.172 92.691 1.00 11.39 A C
ATOM 1514 CGl VAL A 334 52.208 70.860 91.617 1.00 11.36 A C
ATOM 1515 CG2 VAL A 334 51.609 70.350 93.835 1.00 11.50 A C
ATOM 1516 C VAL A 334 51.051 73.398 91.756 1.00 11.41 A C
ATOM 1517 O VAL A 334 52.003 73.996 91.190 1.00 14.84 A O
ATOM 1518 N VAL A 335 49.739 73.439 91.357 1.00 8.70 A N
ATOM 1519 CA VAL A 335 49.285 74.180 90.200 1.00 9.19 A C
ATOM 1520 CB VAL A 335 47.860 73.854 89.751 1.00 11.77 A C
ATOM 1521 CGl VAL A 335 47.525 72.323 89.949 1.00 15.58 A C
ATOM 1522 CG2 VAL A 335 46.890 74.615 90.485 1.00 12.76 A C
ATOM 1523 C VAL A 335 49.574 75.716 90.243 1.00 11.21 A C
ATOM 1524 O VAL A 335 50.027 76.297 89.279 1.00 10.24 A O
ATOM 1525 N MET A 33G 49.327 76.356 91.411 1.00 11.72 A N
ATOM 1526 CA MET A 336 49.513 77.779 91.522 1.00 12.28 A C
ATOM 1527 CB MET A 336 48.758 78.337 92.696 1.00 13.61 A C
ATOM 1528 CG MET A 336 47.299 78.603 92.379 1.00 10.74 A C
ATOM 1529 SD MET A 336 46.566 79.200 93.963 1.00 10.57 A S
ATOM 1530 CE MET A 336 46.796 80.827 93.810 1.00 12.03 A C
ATOM 1531 C MET A 336 51.072 78.126 91.563 1.00 13.91 A C
ATOM 1532 O MET A 336 51.466 79.156 91.042 1.00 13.67 A O
ATOM 1533 N TYR A 337 51.881 77.225 92.119 1.00 13.80 A N
ATOM 1534 CA TYR A 337 53.312 77.294 92.081 1.00 15.40 A C
ATOM 1535 CB TYR A 337 53.993 76.152 92.941 1.00 18.96 A C
ATOM 1536 CG TYR A 337 55.563 76.249 93.023 1.00 19.81 A C
ATOM 1537 CDl TYR A 337 56.308 75.905 91.961 1.00 18.85 A C
ATOM 1538 CEl TYR A 337 57.654 76.112 91.961 1.00 19.93 A C
ATOM 1539 CZ TYR A 337 58.245 76.542 93.075 1.00 18.23 A C
ATOM 1540 OH TYR A 337 59.553 76.685 93.135 1.00 17.14 A O
ATOM 1541 CE2 TYR A 337 57.510 76.869 94.130 1.00 19.14 A C
ATOM 1542 CD2 TYR A 337 56.211 76.710 94.118 1.00 20.34 A C
ATOM 1543 C TYR A 337 53.825 77.278 90.618 1.00 17.01 A C
ATOM 1544 O TYR A 337 54.502 78.154 90.097 1.00 17.47 A O
ATOM 1545 N GLU A 338 53.351 76.283 89.925 1.00 19.71 A N
ATOM 1546 CA GLU A 338 53.567 76.179 88.492 1.00 21.17 A C
ATOM 1547 CB GLU A 338 52.804 74.995 88.049 1.00 24.51 A C
ATOM 1548 CG GLU A 338 53.477 73.624 88.302 1.00 26.56 A C
ATOM 1549 CD GLU A 338 52.753 72.598 87.423 1.00 28.10 A C
ATOM 1550 OEl GLU A 338 51.896 71.941 87.977 1.00 27.70 A O
ATOM 1551 OE2 GLU A 338 52.894 72.557 86.164 1.00 28.66 A O
ATOM 1552 C GLU A 338 53.228 77.422 87.681 1.00 20.91 A C
ATOM 1553 O GLU A 338 54.059 77.907 87.006 1.00 23.88 A O
ATOM 1554 N MET A 339 52.000 77.864 87.689 1.00 20.02 A N
ATOM 1555 CA MET A 339 51.556 78.995 86.985 1.00 17.75 A C
ATOM 1556 CB MET A 339 50.129 79.325 87.430 1.00 15.47 A C
ATOM 1557 CG MET A 339 49.155 78.327 87.104 1.00 19.09 A C
ATOM 1558 SD MET A 339 47.413 78.628 87.659 1.00 19.38 A S
ATOM 1559 CE MET A 339 46.846 78.392 86.294 1.00 24.90 A C
ATOM 1560 C MET A 339 52.433 80.280 87.280 1.00 19.12 A C
ATOM 1561 O MET A 339 52.713 81.014 86.374 1.00 19.08 A O
ATOM 1562 N MET A 340 52.794 80.511 88.520 1.00 18.46 A N
ATOM 1563 CA MET A 340 53.473 81.658 88.929 1.00 19.54 A C
ATOM 1564 CB MET A 340 53.167 82.065 90.403 1.00 20.33 A C
ATOM 1565 CG MET A 340 51.947 83.031 90.524 1.00 18.92 A C
ATOM 1566 SD MET A 340 51.849 83.444 92.337 1.00 20.43 A S
ATOM 1567 CE MET A 340 51.026 82.249 92.923 1.00 18.34 A C
ATOM 1568 C MET A 340 54.967 81.609 88.776 1.00 19.34 A C
ATOM 1569 O MET A 340 55.572 82.720 88.625 1.00 19.89 A O
ATOM 1570 N CYS A 341 55.546 80.405 88.806 1.00 19.94 A N
ATOM 1571 CA CYS A 341 56.968 80.222 88.710 1.00 21.39 A C
ATOM 1572 CB CYS A 341 57.486 79.355 89.896 1.00 16.13 A C
ATOM 1573 SG CYS A 341 57.187 79.932 91.553 1.00 16.33 A S
ATOM 1574 C CYS A 341 57.391 79.604 87.298 1.00 24.87 A C
ATOM 1575 O CYS A 341 58.590 79.557 86.894 1.00 26.74 A O
ATOM 1576 N GLY A 342 56.428 79.102 86.554 1.00 26.29 A N
ATOM 1577 CA GLY A 342 56.776 78.403 85.311 1.00 28.73 A C
ATOM 1578 C GLY A 342 57.612 77.090 85.417 1.00 30.22 A C
ATOM 1579 O GLY A 342 58.397 76.807 84.556 1.00 30.23 A O ATOM 1580 N ARG A 343 57.368 76.287 86.453 1.00 30.67 A N
ATOM 1581 CA ARG A 343 58.102 75.067 86.743 1.00 30.91 A C
ATOM 1582 CB ARG A 343 59.594 75.374 87.128 1.00 31.47 A C
ATOM 1583 CG ARG A 343 59.665 75.962 88.546 1.00 33.42 A C
ATOM 1584 CD ARG A 343 60.975 76.259 89.269 1.00 34.37 A C
ATOM 1585 NE ARG A 343 61.417 77.716 89.193 1.00 35.56 A N
ATOM 158S CZ ARG A 343 61.610 78.586 90.202 1.00 33.56 A C
ATOM 1587 NHl ARG A 343 61.318 78.324 91.485 1.00 31.05 A N
ATOM 1588 NH2 ARG A 343 62.111 79.759 89.878 1.00 34.62 A N
ATOM 1589 C ARG A 343 57.380 74.466 87.954 1.00 31.54 A C
ATOM 1590 O ARG A 343 56.716 75.216 88.851 1.00 29.55 A O
ATOM 1591 N LEU A 344 57.604 73.155 88.115 1.00 31.50 A N
ATOM 1592 CA LEU A 344 56.999 72.431 89.209 1.00 31.05 A C
ATOM 1593 CB LEU A 344 56.896 70.950 88.889 1.00 30.13 A C
ATOM 1594 CG LEU A 344 55.852 70.323 87.983 1.00 30.25 A C
ATOM 1595 CDl LEU A 344 56.328 68.938 87.591 1.00 30.23 A C
ATOM 1596 CD2 LEU A 344 54.432 70.182 88.624 1.00 28.64 A C
ATOM 1597 C LEU A 344 57.821 72.687 90.519 1.00 32.27 A C
ATOM 1598 O LEU A 344 58.967 73.065 90.443 1.00 33.20 A O
ATOM 1599 N PRO A 345 57.215 72.616 91.705 1.00 33.44 A N
ATOM 1600 CA PRO A 345 57.974 72.770 92.960 1.00 34.21 A C
ATOM 1601 CB PRO A 345 56.869 72.839 94.037 1.00 33.75 A C
ATOM 1602 CG PRO A 345 55.501 72.204 93.333 1.00 32.93 A C
ATOM 1603 CD PRO A 345 55.763 72.413 91.922 1.00 33.09 A C
ATOM 1604 C PRO A 345 58.923 71.566 93.240 1.00 35.37 A C
ATOM 1605 O PRO A 345 59.939 71.710 93.844 1.00 35.69 A O
ATOM 1606 N PHE A 346 58.530 70.387 92.794 1.00 37.18 A N
ATOM 1607 CA PHE A 346 59.270 69.182 93.067 1.00 38.56 A C
ATOM 1608 CB PHE A 346 58.514 68.314 94.052 1.00 38.64 A C
ATOM 1609 CG PHE A 346 58.286 68.944 95.335 1.00 39.31 A C
ATOM 1610 CDl PHE A 346 59.343 69.303 96.103 1.00 39.35 A C
ATOM 1611 CEl ' PHE A 346 59.171 69.923 97.271 1.00 38.89 A C
ATOM 1612 CZ PHE A 346 57.874 70.157 97.764 1.00 39.16 A C
ATOM 1613 CE2 PHE A 346 56.782 69.786 97.005 1.00 39.31 A C
ATOM 1614 CD2 PHE A 346 56.984 69.210 95.782 1.00 39.69 A C
ATOM 1615 C PHE A 346 59.426 68.406 91.790 1.00 39.94 A C
ATOM 1616 O PHE A 346 58.422 67.915 91.253 1.00 39.64 A O
ATOM 1617 N TYR A 347 60.674 68.354 91.283 1.00 41.75 A N
ATOM 1618 CA TYR A 347 61.078 67.400 90.175 1.00 44.71 A C
ATOM 1619 CB TYR A 347 61.029 68.043 88.788 1.00 44.60 A C
ATOM 1620 CG TYR A 347 61.031 67.049 87.621 1.00 46.84 A C
ATOM 1621 CDl TYR A 347 60.145 65.962 87.601 1.00 47.59 A C
ATOM 1622 CEl TYR A 347 60.190 65.001 86.557 1.00 47.20 A C
ATOM 1623 CZ TYR A 347 61.068 65.156 85.521 1.00 46.68 A C
ATOM 1624 OH TYR A 347 60.990 64.184 84.531 1.00 46.99 A O
ATOM 1625 CE2 TYR A 347 61.986 66.204 85.508 1.00 46.51 A C
ATOM 1626 CD2 TYR A 347 61.969 67.137 86.553 1.00 46.87 A C
ATOM 1627 C TYR A 347 62.405 66.547 90.364 1.00 45.45 A C
ATOM 1628 O TYR A 347 63.271 66.804 91.222 1.00 45.56 A O
ATOM 1629 N ASN A 348 62.426 65.471 89.582 1.00 46.57 A N
ATOM 1630 CA ASN A 348 63.570 64.524 89.357 1.00 47.63 A C
ATOM 1631 CB ASN A 348 64.163 63.956 90.661 1.00 46.51 A C
ATOM 1632 CG ASN A 348 65.450 63.182 90.427 1.00 45.87 A C
ATOM 1633 ODl ASN A 348 65.644 62.536 89.399 1.00 45.93 A O
ATOM 1634 ND2 ASN A 348 66.306 63.205 91.414 1.00 44.72 A N
ATOM 1635 C ASN A 348 62.979 63.340 88.645 1.00 48.25 A C
ATOM 1636 O ASN A 348 61.993 62.750 89.195 1.00 47.92 A O
ATOM 1637 N GLN A 349 63.525 62.951 87.470 1.00 50.23 A N
ATOM 1638 CA GLN A 349 62.932 61.761 86.789 1.00 51.35 A C
ATOM 1639 CB GLN A 349 63.172 61.685 85.263 1.00 51.67 A C
ATOM 1640 CG GLN A 349 62.077 60.794 84.473 1.00 53.25 A C
ATOM 1641 CD GLN A 349 62.335 60.665 82.938 1.00 53.69 A C
ATOM 1642 OEl GLN A 349 63.348 60.055 82.523 1.00 54.09 A O
ATOM 1643 NE2 GLN A 349 61.397 61.202 82.109 1.00 53.71 A N
ATOM 1644 C GLN A 349 63.156 60.406 87.493 1.00 51.27 A C
ATOM 1645 O GLN A 349 62.958 59.390 86.848 1.00 52.39 A O
ATOM 1646 N ASP A 350 63.428 60.406 88.808 1.00 51.19 A N
ATOM 1647 CA ASP A 350 63.461 59.202 89.664 1.00 52.19 A C
ATOM 1648 CB ASP A 350 64.888 59.044 90.270 1.00 52.29 .A C
ATOM 1649 CG ASP A 350 65.031 57.908 91.308 1.00 52.56 A C
ATOM 1650 ODl ASP A 350 64.027 57.331 91.835 1.00 50.64 A O
ATOM 1651 OD2 ASP A 350 66.209 57.543 91.638 1.00 52.68 A O
ATOM 1652 C ASP A 350 62.431 59.246 90.806 1.00 52.41 A C ATOM 1653 O ASP A 350 62.703 59.829 91.866 1.00 51.84 A O
ATOM 1654 N HIS A 351 61.310 58.552 90.605 1.00 52.78 A N
ATOM 1655 CA HIS A 351 60.232 58.590 91.553 1.00 53.60 A C
ATOM 1656 CB HIS A 351 59.279 57.376 91.431 1.00 54.83 A C
ATOM 1657 CG HIS A 351 58.392 57.473 90.228 1.00 56.97 A C
ATOM 1658 NDl HIS A 351 57.502 56.485 89.853 1.00 57.94 A N
ATOM 1659 CEl HIS A 351 56.882 56.856 88.739 1.00 58.13 A C
ATOM 1660 NE2 HIS A 351 57.354 58.038 88.362 1.00 58.10 A N
ATOM 1661 CD2 HIS A 351 58.291 58.453 89.281 1.00 57.71 A C
ATOM 1662 C HIS A 351 60.819 58.782 92.906 1.00 53.19 A C
ATOM 1663 O HIS A 351 60.769 59.856 93.387 1.00 54.59 A O
ATOM 1664 N GLU A 352 61.392 57.763 93.493 1.00 52.59 A N
ATOM 1665 CA GLU A 352 61.917 57.751 94.854 1.00 52.29 A C
ATOM 1666 CB GLU A 352 62.788 56.456 94.970 1.00 53.81 A C
ATOM 1667 CG GLU A 352 63.438 56.061 96.310 1.00 55.04 A C
ATOM 1668 CD GLU A 352 64.670 55.156 96.110 1.00 56.19 A C
ATOM 1669 OEl GLU A 352 64.498 54.079 95.442 1.00 54.83 A O
ATOM 1670 OE2 GLU A 352 65.809 55.545 96.600 1.00 57.59 A O
ATOM 1671 C GLU A 352 62.680 59.035 95.259 1.00 50.93 A C
ATOM 1672 O GLU A 352 62.346 59.614 96.283 1.00 50.92 A O
ATOM 1673 N LYS A 353 63.649 59.499 94.469 1.00 49.28 A N
ATOM 1674 CA LYS A 353 64.345 60.741 94.753 1.00 47.98 A C
ATOM 1675 CB LYS A 353 65.588 60.888 93.867 1.00 48.25 A C
ATOM 1676 CG LYS A 353 66.782 59.992 94.331 1.00 49.72 A C
ATOM 1677 CD LYS A 353 67.936 59.971 93.288 1.00 50.19 A C
ATOM 1678 CE LYS A 353 69.331 59.524 93.835 1.00 48.95 A C
ATOM 1679 NZ LYS A 353 70.292 59.275 92.648 1.00 48.70 A N
ATOM 1680 C LYS A 353 63.489 61.981 94.582 1.00 46.64 A C
ATOM 1681 O LYS A 353 63.909 63.075 94.950 1.00 46.80 A O
ATOM 1682 N LEU A 354 62.378 61.785 93.882 1.00 45.37 A N
ATOM 1683 CA LEU A 354 61.283 62.693 93.699 1.00 42.45 A C
ATOM 1684 CB LEU A 354 60.487 62.297 92.514 1.00 42.91 A C
ATOM 1685 CG LEU A 354 59.080 62.878 92.291 1.00 43.67 A C
ATOM 1686 CDl LEU A 354 59.076 64.278 91.793 1.00 42.17 A C
ATOM 1687 CD2 LEU A 354 58.351 61.910 91.296 1.00 43.59 A C
ATOM 1688 C LEU A 354 60.357 62.684 94.841 1.00 41.64 A C
ATOM 1689 O LEU A 354 59.958 63.771 95.270 1.00 40.77 A O
ATOM 1690 N PHE A 355 59.935 61.486 95.296 1.00 40.98 A N
ATOM 1691 CA PHE A 355 59.049 61.331 96.512 1.00 40.77 A C
ATOM 1692 CB PHE A 355 58.753 59.860 96.846 1.00 40.37 A C
ATOM 1693 CG PHE A 355 57.856 59.172 95.893 1.00 40.52 A C
ATOM 1694 CDl PHE A 355 57.486 59.740 94.682 1.00 41.59 A C
ATOM 1695 CEl PHE A 355 56.624 59.032 93.761 1.00 43.22 A C
ATOM 1696 CZ PHE A 355 56.115 57.784 94.082 1.00 42.25 A C
ATOM 1697 CE2 PHE A 355 56.529 57.191 95.241 1.00 42.71 A C
ATOM 1698 CD2 PHE A 355 57.392 57.908 96.187 1.00 41.80 A C
ATOM 1699 C PHE A 355 59.881 61.910 97.658 1.00 40.50 A C
ATOM 1700 O PHE A 355 59.465 62.735 98.458 1.00 40.96 A O
ATOM 1701 N GLU A 356 61.116 61.476 97.663 1.00 38.39 A N
ATOM 1702 CA GLU A 356 62.130 62.048 98.488 1.00 37.28 A C
ATOM 1703 CB GLU A 356 63.478 61.790 97.747 1.00 37.52 A C
ATOM 1704 CG GLU A 356 64.580 61.278 98.611 1.00 39.41 A C
ATOM 1705 CD GLU A 356 64.716 62.055 99.909 1.00 40.04 A C
ATOM 1706 OEl GLU A 356 64.313 61.440 100.947 1.00 41.97 A O
ATOM 1707 OE2 GLU A 356 65.260 63.219 99.897 1.00 40.99 A O
ATOM 1708 C GLU A 356 61.961 63.552 98.698 1.00 35.47 A C
ATOM 1709 O GLU A 356 62.068 64.076 99.809 1.00 34.64 A O
ATOM 1710 N LEU A 357 61.883 64.244 97.590 1.00 33.54 A N
ATOM 1711 CA LEU A 357 61.764 65.678 97.564 1.00 32.76 A C
ATOM 1712 CB LEU A 357 61.838 66.117 96.076 1.00 31.50 A C
ATOM 1713 CG LEU A 357 63.249 65.754 95.545 1.00 31.21 A C
ATOM 1714 CDl LEU A 357 63.702 66.581 94.460 1.00 30.46 A C
ATOM 1715 CD2 LEU A 357 64.252 66.040 96.648 1.00 30.59 A C
ATOM 1716 C LEU A 357 60.476 66.110 98.138 1.00 33.24 A C
ATOM 1717 O LEU A 357 60.375 66.936 99.092 1.00 30.55 A O
ATOM 1718 N ILE A 358 59.473 65.406 97.633 1.00 34.67 A N
ATOM 1719 CA ILE A 358 58.109 65.710 97.953 1.00 36.28 A C
ATOM 1720 CB ILE A 358 57.165 64.847 97.186 1.00 36.39 A C
ATOM 1721 CGl ILE A 358 57.095 65.391 95.762 1.00 36.18 A C
ATOM 1722 CDl ILE A 358 56.633 64.288 94.832 1.00 37.28 A C
ATOM 1723 CG2 ILE A 358 55.693 64.889 97.794 1.00 36.96 A C
ATOM 1724 C ILE A 358 57.871 65.641 99.376 1.00 37.40 A C
ATOM 1725 O ILE A 358 56.924 66.242 99.829 1.00 39.33 A O ATOM 1726 N LEU A 359 58.698 65.010 100.165 .00 37.84 A N ATOM 1727 CA LEU A 359 58.412 65.275 101.579 ,00 38.83 A C ATOM 1728 CB LEU A 359 57.550 64.195 102.129 ,00 38.03 A C ATOM 1729 CG LEU A 359 58.035 62.819 101.733 .00 36.07 A C ATOM 1730 CDl LEU A 359 59.409 62.779 102.500 ,00 37.95 A C ATOM 1731 CD2 LEU A 359 56.993 61.783 102.113 ,00 34.37 A C ATOM 1732 C LEU A 359 59.568 65.568 102.495 .00 39.65 A C ATOM 1733 O LEU A 359 59.374 65.634 103.680 .00 39.68 A O ATOM 1734 N MET A 360 60.700 65.929 101.897 .00 39.81 A N ATOM 1735 CA MET A 360 61.895 66.091 102.655 .00 40.33 A C ATOM 1736 CB MET A 360 62.913 65.027 102.234 .00 41.99 A C ATOM 1737 CG MET A 360 63.840 64.405 103.372 ,00 44.86 A C ATOM 1738 SD MET A 360 63.137 63.730 104.982 .00 46.20 A S ATOM 1739 CE MET A 360 63.735 64.989 106.187 ,00 47.56 A C ATOM 1740 C MET A 360 62.392 67.421 102.372 ,00 39.37 A C ATOM 1741 O MET A 360 63.257 67.876 103.142 .00 39.55 A O ATOM 1742 N GLU A 361 61.822 68.104 101.344 ,00 38.77 A N ATOM 1743 CA GLU A 361 62.518 69.250 100.707 .00 37.40 A C ATOM 1744 CB GLU A 361 63.079 68.877 99.318 1.00 39.23 A C ATOM 1745 CG GLU A 361 64.490 68.152 99.199 40.43 A C ATOM 1746 CD GLU A 361 65.746 68.656 99.994 41.50 A C ATOM 1747 OEl GLU A 361 65.970 68.114 101.174 41.94 A O ATOM 1748 OE2 GLU A 361 66.567 69.466 99.397 41.00 A O ATOM 1749 C GLU A 361 61.626 70.511 100.592 36.21 A C ATOM 1750 O GLU A 361 60.518 70.469 100.064 1.00 36.58 A O ATOM 1751 N ASP A 362 62.106 71.602 101.130 34.26 A N ATOM 1752 CA ASP A 362 61.396 72.848 101.224 33.91 A C ATOM 1753 CB ASP A 362 62.047 73.797 102.207 34.60 A C ATOM 1754 CG ASP A 362 62.043 73.284 103.676 36.96 A C ATOM 1755 ODl ASP A 362 61.290 72.366 104.064 37.07 A O ATOM 1756 OD2 ASP A 362 62.784 73.835 104.580 38.42 A O ATOM 1757 C ASP A 362 61.496 73.468 99.867 33.10 A C ATOM 1758 O ASP A 362 62.443 73.229 99.188 33.45 A O ATOM 1759 N ILE A 363 60.460 74.191 99.466 33.32 A N ATOM 1760 CA ILE A 363 60.316 74.691 98.124 33.07 A C ATOM 1761 CB ILE A 363 58.805 74.998 97.638 1.00 33.28 A C ATOM 1762 CGl ILE A 363 57.826 75.377 98.743 .00 32.50 A C ATOM 1763 CDl ILE A 363 57.323 76.670 99.094 .00 32.39 A C ATOM 1764 CG2 ILE A 363 58.147 73.842 96.877 .00 33.49 A C ATOM 1765 C ILE A 363 61.040 76.001 98.186 .00 33.15 A C ATOM 1766 O ILE A 363 61.144 76.622 99.238 .00 31.83 A O ATOM 1767 N LYS A 364 61.553 76.381 97.044 1.00 33.40 A N ATOM 1768 CA LYS A 364 62.189 77.624 96.828 1.00 34.09 A C ATOM 1769 CB LYS A 364 63.593 77.356 96.206 1.00 34.59 A C ATOM 1770 CG LYS A 364 64.422 76.433 97.056 1.00 35.99 A C ATOM 1771 CD LYS A 364 65.137 77.200 98.200 1.00 39.39 A C ATOM 1772 CE LYS A 364 66.009 76.241 99.094 1.00 41.17 A C ATOM 1773 NZ LYS A 364 65.883 76.517 100.614 00 40.38 A N ATOM 1774 C LYS A 364 61.241 78.301 95.801 00 33.04 A C ATOM 1775 O LYS A 364 60.540 77.595 95.041 00 32.85 A O ATOM 1776 N PHE A 365 61.244 79.648 95.843 00 33.17 A N ATOM 1777 CA PHE A 365 60.548 80.553 94.984 00 32.99 A C ATOM 1778 CB PHE A 365 59.616 81.414 95.798 00 31.63 A C ATOM 1779 CG PHE A 365 58.707 80.657 96.698 00 30.23 A C ATOM 1780 CDl PHE A 365 57.611 79.981 96.164 00 29.62 A C ATOM 1781 CEl PHE A 365 56.769 79.253 96.934 00 30.33 A C ATOM 1782 CZ PHE A 365 56.963 79.212 98.318 00 30.20 A C ATOM 1783 CE2 PHE A 365 58.056 79.914 98.927 00 30.44 A C ATOM 1784 CD2 PHE A 365 58.938 80.655 98.079 00 29.81 A C ATOM 1785 C PHE A 365 61.480 81.518 94.311 00 33.74 A C ATOM 1786 O PHE A 365 62.581 81.775 94.782 00 34.55 A O ATOM 1787 N PRO A 366 61.076 82.056 93.177 00 34.33 A N ATOM 1788 CA PRO A 366 61.789 83.224 92.585 00 32.97 A C ATOM 1789 CB PRO A 366 60.875 83.638 91.417 00 32.07 A C ATOM 1790 CG PRO A 366 60.246 82.173 91.010 00 34.00 A C ATOM 1791 CD PRO A 366 59.948 81.579 92.348 00 32.79 A C ATOM 1792 C PRO A 366 61.910 84.368 93.575 00 32.89 A C ATOM 1793 O PRO A 366 60.956 84.513 94.317 00 34.85 A O ATOM 1794 N ARG A 367 62.991 85.153 93.608 1.00 33.34 A H ATOM 1795 CA ARG A 367 63.046 86.262 94.552 1.00 32.67 A C ATOM 1796 CB ARG A 367 64.472 86.901 94.676 1.00 35.22 A C ATOM 1797 CG ARG A 367 65.677 86.001 95.205 1.00 37.89 A C ATOM 1798 CD ARG A 367 67.226 86.646 94.902 1.00 40.33 A C ATOM 1799 NE ARG A 367 67.401 87.029 93.469 1.00 41.56 A N
ATOM 1800 C2 ARG A 367 68.158 88.047 93.003 41.06 A C
ATOM 1801 NHl ARG A 367 68.896 88.720 93.828 41.12 A N
ATOM 1802 NH2 ARG A 367 68.203 88.336 91.727 39.38 A N
ATOM 1803 C ARG A 367 61.983 87.359 94.256 31.54 A C
ATOM 1804 O ARG A 367 61.507 87.995 95.226 1.00 31.76 A O
ATOM 1805 N THR A 368 61.615 87.605 92.995 28.68 A N
ATOM 1806 CA THR A 368 60.592 88.637 92.683 27.67 A C
ATOM 1807 CB THR A 368 60.686 89.107 91.302 28.06 A C
ATOM 1808 OGl THR A 368 60.824 87.977 90.467 1.00 30.10 A O
ATOM 1809 CG2 THR A 368 62.042 89.884 91.138 .00 26.63 A C
ATOM 1810 C THR A 368 59.128 88.332 92.992 .00 28.00 A C
ATOM 1811 O THR A 368 58.257 89.255 92.924 .00 28.63 A O
ATOM 1812 N LEU A 369 58.877 87.117 93.469 .00 25.16 A N
ATOM 1813 CA LEU A 369 57.590 86.736 93.812 .00 23.28 A C
ATOM 1814 CB LEU A 369 57.587 85.236 94.155 .00 23.39 A C
ATOM 1815 CG LEU A 369 56.215 84.592 93.997 .00 24.95 A C
ATOM 1816 CDl LEU A 3S9 55.717 84.550 92.469 .00 25.55 A C
ATOM 1817 CD2 LEU A 369 56.200 83.267 94.669 .00 23.46 A C
ATOM 1818 C LEU A 369 57.127 87.511 95.049 1.00 21.81 A C
ATOM 1819 O LEU A 369 57.847 87.521 96.070 1.00 20.67 A O
ATOM 1820 N SER A 370 55.860 88.016 95.033 1.00 19.57 A N
ATOM 1821 CA SER A 370 55.382 88.726 96.206 1.00 16.60 A C
ATOM 1822 CB SER A 370 53.915 89.220 95.994 1.00 16.90 A C
ATOM 1823 OG SER A 370 53.017 88.218 95.905 15.68 A O
ATOM 1824 C SER A 370 55.456 87.968 97.473 16.75 A C
ATOM 1825 O SER A 370 55.295 86.762 97.410 15.92 A O
ATOM 1826 N SER A 371 55.547 88.672 98.613 16.40 A N
ATOM 1827 CA SER A 371 55.463 88.015 99.879 18.25 A C
ATOM 1828 CB SER A 371 55.596 88.956 101.032 19.11 A C
ATOM 1829 OG SER A 371 56.313 90.002 100.450 23.84 A O
ATOM 1830 C SER A 371 54.140 87.240 100.078 1.00 18.24 A C
ATOM 1831 O SER A 371 54.186 86.293 100.731 .00 21.25 A O
ATOM 1832 N ASP A 372 53.007 87.665 99.624 .00 19.24 A N
ATOM 1833 CA ASP A 372 51.749 86.918 99.924 .00 19.16 A C
ATOM 1834 CB ASP A 372 50.440 87.734 99.584 .00 18.59 A C
ATOM 1835 CG ASP A 372 50.240 88.916 100.386 .00 18.01 A C
ATOM 1836 ODl ASP A 372 50.760 88.942 101.597 .00 25.08 A • O
ATOM 1837 OD2 ASP A 372 49.615 89.906 99.942 1.00 22.01 A O
ATOM 1838 C ASP A 372 51.694 85.647 99.078 1.00 18.86 A C
ATOM 1839 O ASP A 372 51.115 84.721 99.485 1.00 20.39 A O
ATOM 1840 N ALA A 373 52.154 85.717 97.851 1.00 20.55 A N
ATOM 1841 CA ALA A 373 52.412 84.590 96.984 1.00 20.73 A C
ATOM 1842 CB ALA A 373 53.030 85.089 95.610 1.00 20.92 A C
ATOM 1843 C ALA A 373 53.270 83.494 97.603 1.00 20.54 A C
ATOM 1844 O ALA A 373 52.889 82.396 97.577 1.00 23.29 A O
ATOM 1845 N LYS A 374 54.415 83.837 98.168 1.00 20.97 A N
ATOM 1846 CA LYS A 374 55.308 82.859 98.885 1.00 20.05 A C
ATOM 1847 CB LYS A 374 56.635 83.489 99.232 1.00 21.01 A C
ATOM 1848 CG LYS A 374 57.508 83.810 97.950 .00 22.00 A C
ATOM 1849 CD LYS A 374 58.718 84.542 98.543 .00 25.02 A C
ATOM 1850 CE LYS A 374 59.601 85.312 97.599 .00 26.16 A C
ATOM 1851 NZ LYS A 374 60.594 84.176 97.704 .00 31.09 A N
ATOM 1852 C LYS A 374 54.681 82.421 100.120 .00 17.52 A C
ATOM 1853 O LYS A 374 54.686 81.306 100.494 .00 17.69 A O
ATOM 1854 N SER A 375 54.045 83.287 100.755 .00 14.85 A N
ATOM 1855 CA SER A 375 53.293 82.850 101.880 .00 15.93 A C
ATOM 1856 CB SER A 375 52.562 84.023 102.519 .00 14.39 A C
ATOM 1857 OG SER A 375 51.897 83.636 103.713 .00 20.03 A O
ATOM 1858 C SER A 375 52.153 81.803 101.521 .00 16.95 A C
ATOM 1859 O SER A 375 52.031 80.717 102.092 .00 15.72 A O
ATOM 1860 N LEU A 376 51.358 82.141 100.519 .00 15.17 A N
ATOM 1861 CA LEU A 376 50.229 81.314 100.213 .00 15.20 A C
ATOM 1862 CB LEU A 376 49.398 81.962 99.093 1.00 14.10 A C
ATOM 1863 CG LEU A 376 48.394 80.959 98.539 1.00 12.01 A C
ATOM 1864 CDl LEU A 376 47.201 80.999 99.285 1.00 9.56 A C
ATOM 1865 CD2 LEU A 376 48.149 81.307 97.157 1.00 9.59 A C
ATOM 1866 C LEU A 376 50.718 79.890 99.840 1.00 14.89 A C
ATOM 1867 O LEU A 376 50.339 78.920 100.429 1.00 14.60 A O
ATOM 1868 N LEU A 377 51.645 79.883 98.900 1.00 15.36 A N
ATOM 1869 CA LEU A 377 52.299 78.676 98.379 1.00 15.72 A C
ATOM 1870 CB LEU A 377 53.316 79.005 97.341 1.00 14.86 A C
ATOM 1871 CG LEU A 377 52.641 79.692 96.106 1.00 14.36 A C ATOM 1872 CDl LEU A 377 53.786 80.001 95.006 1.00 11.92 A C
ATOM 1873 CD2 LEU A 377 51.638 79.002 95.507 1.00 10.34 A C
ATOM 1874 C LEU A 377 52.982 77.864 99.391 1.00 14.50 A C
ATOM 1875 O LEU A 377 52.834 76.648 99.403 1.00 15.23 A O
ATOM 187S N SER A 378 53.566 78.552 100.362 1.00 15.31 A N
ATOM 1877 CA SER A 378 54.148 77.868 101.555 1.00 17.00 A C
ATOM 1878 CB SER A 378 54.847 78.852 102.426 1.00 17.03 A C
ATOM 1879 OG SER A 378 56.037 79.263 101.835 1.00 22.21 A O
ATOM 1880 C SER A 378 53.166 77.167 102.386 1.00 15.43 A C
ATOM 1881 O SER A 378 53.383 75.977 102.853 1.00 16.30 A O
ATOM 1882 N GLY A 379 52.057 77.850 102.643 1.00 16.10 A N
ATOM 1883 CA GLY A 379 51.051 77.228 103.565 1.00 15.01 A C
ATOM 1884 C GLY A 379 50.416 76.072 102.863 1.00 14.26 A C
ATOM 1885 O GLY A 379 50.054 75.073 103.492 1.00 16.43 A O
ATOM 188S N LEU A 380 50.222 76.197 101.568 1.00 12.03 A N
ATOM 1887 CA LEU A 380 49.466 75.189 100.812 1.00 12.91 A C
ATOM 1888 CB LEU A 380 49.142 75.643 99.406 1.00 11.14 A C
ATOM 1889 CG LEU A 380 48.013 76.695 99.230 1.00 12.70 A C
ATOM 1890 CDl LEU A 380 47.915 77.156 97.751 1.00 7.78 A C
ATOM 1891 CD2 LEU A 380 46.734 76.144 99.782 1.00 9.83 A C
ATOM 1892 C LEU A 380 50.328 73.867 100.725 1.00 13.89 A C
ATOM 1893 O LEU A 380 49.824 72.800 100.532 1.00 12.62 A O
ATOM 1894 N LEU A 381 51.673 74.056 100.795 1.00 15.92 A N
ATOM 1895 CA LEU A 381 52.660 73.053 100.566 1.00 15.60 A C
ATOM 1896 CB LEU A 381 53.656 73.460 99.508 1.00 15.44 A C
ATOM 1897 CG LEU A 381 53.266 73.669 98.064 1.00 15.47 A C
ATOM 1898 CDl LEU A 381 54.456 73.915 97.129 1.00 14.45 A C
ATOM 1899 CD2 LEU A 381 52.591 72.551 97.466 1.00 13.19 A C
ATOM 1900 C LEU A 381 53.311 72.747 101.850 1.00 17.54 A C
ATOM 1901 O LEU A 381 54.309 72.148 101.860 1.00 18.19 A O
ATOM 1902 N ILE A 382 52.707 73.068 102.956 1.00 18.21 A N
ATOM 1903 CA ILE A 382 53.109 72.471 104.213 1.00 18.19 A C
ATOM 1904 CB ILE A 382 52.224 72.994 105.320 1.00 17.32 A C
ATOM 1905 CGl ILE A 382 52.697 74.378 105.879 1.00 20.92 A C
ATOM 1906 CDl ILE A 382 51.597 75.249 106.766 1.00 22.10 A C
ATOM 1907 CG2 ILE A 382 52.387 72.146 106.431 1.00 18.88 A C
ATOM 1908 C I1)E A 382 52.967 70.887 104.091 1.00 20.71 A C
ATOM 1909 O ILE A 382 52.057 70.328 103.438 1.00 19.73 A O
ATOM 1910 N LYS A 383 53.949 70.195 104.654 1.00 22.67 A N
ATOM 1911 CA LYS A 383 54.060 68.726 104.511 1.00 24.48 A C
ATOM 1912 CB LYS A 383 55.452 68.154 104.986 1.00 24.86 A C
ATOM 1913 CG LYS A 383 56.685 68.924 104.337 1.00 24.43 A C
ATOM 1914 CD LYS A 383 57.021 68.686 102.867 1.00 22.69 A C
ATOM 1915 CE LYS A 383 58.319 69.179 102.388 1.00 22.57 A C
ATOM 1916 NZ LYS A 383 58.441 69.261 100.851 1.00 23.04 A N
ATOM 1917 C LYS A 383 52.956 68.168 105.339 1.00 24.19 A C
ATOM 1918 O LYS A 383 52.286 67.352 104.900 1.00 24.61 A O
ATOM 1919 N ASP A 384 52.797 68.637 106.559 1.00 25.86 A N
ATOM 1920 CA ASP A 384 51.837 68.038 107.462 1.00 26.23 A C
ATOM 1921 CB ASP A 384 52.225 68.303 108.866 1.00 25.10 A C
ATOM 1922 CG ASP A 384 51.221 67.699 109.853 1.00 27.42 A C
ATOM 1923 ODl ASP A 384 50.152 67.193 109.494 1.00 27.18 A O
ATOM 1924 OD2 ASP A 384 51.372 67.786 111.096 1.00 29.77 A O
ATOM 1925 C ASP A 384 50.424 68.559 107.131 1.00 27.89 A C
ATOM 1926 O ASP A 384 50.103 69.778 107.235 1.00 28.04 A O
ATOM 1927 N PRO A 385 49.625 67.679 106.608 1.00 28.45 A N
ATOM 1928 CA PRO A 385 48.246 68.013 106.303 1.00 29.47 A C
ATOM 1929 CB PRO A 385 47.615 66.641 105.998 1.00 29.99 A C
ATOM 1930 CG PRO A 385 48.701 65.655 106.436 1.00 29.89 A C
ATOM 1931 CD PRO A 385 49.962 66.344 106.107 1.00 29.06 A C
ATOM 1932 C PRO A 385 47.432 68.676 107.365 1.00 29.98 A C
ATOM 1933 O PRO A 385 46.564 69.353 106.971 1.00 30.76 A O
ATOM 1934 N ASN A 386 47.625 68.434 108.656 1.00 30.72 A N
ATOM 1935 CA ASN A 386 46.853 69.116 109.718 1.00 29.84 A C
ATOM 1936 CB ASN A 386 47.115 68.438 111.006 1.00 32.79 A C
ATOM 1937 CG ASN A 386 46.778 67.012 110.978 1.00 35.92 A C
ATOM 1938 ODl ASN A 386 47.661 66.150 110.877 1.00 40.12 A O
ATOM 1939 ND2 ASN A 386 45.486 66.730 111.011 1.00 36.73 A N
ATOM 1940 C ASN A 386 47.266 70.568 109.946 1.00 28.44 A C
ATOM 1941 O ASN A 386 46.496 71.369 110.500 1.00 28.64 A O
ATOM 1942 N LYS A 387 48.496 70.860 109.570 1.00 25.78 A N
ATOM 1943 CA LYS A 387 49.108 72.198 109.677 1.00 23.87 A C
ATOM 1944 CB LYS A 387 50.640 72.111 110.008 1.00 24.32 A C T7US2004/026569
ATOM 1945 CG LYS A 387 50.969 71.246 111.221 1.00 24.96 A C
ATOM 1946 CD LYS A 387 50.127 71.656 112.480 1.00 27.22 A C
ATOM 1947 CE LYS A 387 50.436 73.210 112.813 1.00 31.52 A C
ATOM 1948 NZ LYS A 387 50.316 73.779 114.299 1.00 32.46 A N
ATOM 1949 C LYS A 387 48.980 72.999 108.389 .00 22.05 A C
ATOM 1950 O LYS A 387 49.132 74.218 108.409 .00 23.53 A O
ATOM 1951 N ARG A 388 48.650 72.323 107.291 .00 20.36 A N
ATOM 1952 CA ARG A 388 48.610 72.938 105.962 .00 18.04 A C
ATOM 1953 CB ARG A 388 48.575 71.877 104.911 ,00 17.18 A C
ATOM 1954 CG ARG A 388 48.378 72.320 103.632 .00 18.96 A C
ATOM 1955 CD ARG A 388 48.962 71.438 102.646 .00 15.80 A C
ATOM 1956 NE ARG A 388 48.236 70.283 102.384 .00 20.43 A N
ATOM 1957 CZ ARG A 388 48.639 68.945 102.509 ,00 20.55 A C
ATOM 1958 NHl ARG A 388 49.827 68.586 102.911 ,00 20.54 A N
ATOM 1959 NH2 ARG A 388 47.714 67.969 102.256 00 18.65 A N
ATOM 1960 C ARG A 388 47.455 73.855 105.812 .00 17.73 A C
ATOM 1961 O ARG A 388 46.447 73.616 106.354 1.00 17.58 A O
ATOM 1962 N LEU A 389 47.723 74.986 105.192 1.00 17.06 A N
ATOM 1963 CA LEU A 389 46.718 75.943 104.881 1.00 15.49 A C
ATOM 1964 CB LEU A 389 47.314 77.042 103.983 1.00 13.33 A C
ATOM 1965 CG LEU A 389 46.296 78.183 103.678 1.00 15.29 A C
ATOM 1966 CDl LEU A 389 46.063 79.181 104.840 1.00 14.17 A C
ATOM 1967 CD2 LEU A 389 46.836 78.860 102.616 1.00 14.26 A C
ATOM 1968 C LEU A 389 45.457 75.319 104.242 1.00 15.35 A C
ATOM 1969 O LEU A 389 45.561 74.644 103.304 1.00 14.64 A O
ATOM 1970 N GLY A 390 44.259 75.525 104.788 15.54 A N
ATOM 1971 CA GLY A 390 43.039 74.934 104.215 14.35 A C
ATOM 1972 C GLY A 390 42.654 73.662 104.931 16.23 A C
ATOM 1973 O GLY A 390 41.493 73.164 104.813 14.00 A O
ATOM 1974 N GLY A 391 43.630 73.164 105.705 15.50 A N
ATOM 1975 CA GLY A 391 43.554 71.901 106.389 16.65 A C
ATOM 1976 C GLY A 391 42.928 71.975 107.754 16.55 A C
ATOM 1977 O GLY A 391 42.792 71.007 108.304 15.82 A O
ATOM 1978 N GLY A 392 42.535 73.103 108.273 18.36 A N
ATOM 1979 CA GLY A 392 41.747 73.143 109.463 1.00 19.61 A C
ATOM 1980 C GLY A 392 40.186 73.117 109.201 20.06 A C
ATOM 1981 O GLY A 392 39.700 72.958 108.051 20.42 A. O
ATOM 1982 N PRO A 393 39.433 73.256 110.300 19.19 A N
ATOM 1983 CA PRO A 393 38.005 73.007 110.303 18.82 A C
ATOM 1984 CB PRO A 393 37.600 73.178 111.803 17.44 A C
ATOM 1985 CG PRO A 393 38.596 73.972 112.372 17.91 A C
ATOM 1986 CD PRO A 393 39.897 73.542 111.667 19.18 A C
ATOM 1987 C PRO A 393 37.255 73.985 109.378 19.19 A C
ATOM 1988 O PRO A 393 36.186 73.600 108.967 19.09 A O
ATOM 1989 N ASP A 394 37.760 75.169 109.069 17.75 A N
ATOM 1990 CA ASP A 394 37.075 76.030 108.106 18.51 A C
ATOM 1991 CB ASP A 394 37.362 77.503 108.442 17.36 A C
ATOM 1992 CG ASP A 394 36.167 78.266 108.623 15.95 A C
ATOM 1993 ODl ASP A 394 35.045 77.669 108.707 16.13 A O
ATOM 1994 OD2 ASP A 394 36.255 79.437 108.816 1.00 14.52 A O
ATOM 1995 C ASP A 394 37.435 75.744 106.578 .00 18.98 A C
ATOM 1996 O ASP A 394 37.061 76.418 105.627 00 19.71 A O
ATOM 1997 N ASP A 395 38.276 74.791 106.405 ,00 20.51 A N
ATOM 1998 CA ASP A 395 38.608 74.313 105.098 ,00 20.26 A C
ATOM 1999 CB ASP A 395 37.497 73.347 104.624 .00 19.38 A C
ATOM 2000 CG ASP A 395 37.783 72.768 103.277 .00 19.89 A C
ATOM 2001 ODl ASP A 395 38.719 71.939 103.145 ,00 19.16 A O
ATOM 2002 OD2 ASP A 395 37.122 73.118 102.313 ,00 19.31 A O
ATOM 2003 C ASP A 395 38.957 75.470 104.154 .00 20.10 A C
ATOM 2004 O ASP A 395 39.979 76.230 104.369 .00 20.94 A O
ATOM 2005 N ALA A 396 38.182 75.595 103.098 ,00 19.03 A N
ATOM 2006 CA ALA A 396 38.509 76.564 102.089 .00 19.07 A C
ATOM 2007 CB ALA A 396 37.570 76.399 101.039 1.00 20.83 A C
ATOM 2008 C ALA A 396 38.544 78.071 102.596 1.00 19.02 A C
ATOM 2009 O ALA A 396 39.285 78.873 102.113 1.00 18.75 A O
ATOM 2010 N LYS A 397 37.792 78.366 103.655 1.00 18.79 A N
ATOM 2011 CA LYS A 397 37.791 79.712 104.198 1.00 18.61 A C
ATOM 2012 CB LYS A 397 36.759 79.919 105.287 1.00 21.25 A C
ATOM 2013 CG LYS A 397 35.269 80.021 104.764 1.00 20.50 A C
ATOM 2014 CD LYS A 397 34.677 78.611 104.543 1.00 21.96 A C
ATOM 2015 CE LYS A 397 33.074 78.704 104.457 1.00 24.94 A C
ATOM 2016 NZ LYS A 397 32.462 79.395 103.171 1.00 25.88 A N
ATOM 2017 C LYS A 397 39.167 80.209 104.682 1.00 18.12 A C ATOM 201S O LYS A 397 39.397 81.423 104.583 1.00 16.88 A O
ATOM 2019 N GLU A 398 40.044 79.317 105.143 1.00 17.25 A N
ATOM 2020 CA GLU A 398 41.423 79.735 105.461 1.00 15.90 A C
ATOM 2021 CB GLU A 398 42.338 78.648 106.035 1.00 17.42 A C
ATOM 2022 CG GLU A 398 41.888 77.968 107.322 1.00 20.10 A C
ATOM 2023 CD GLU A 398 42.795 76.732 107.790 00 19.84 A C
ATOM 2024 OEl GLU A 398 42.413 75.905 108.692 00 21.09 A O
ATOM 2025 OE2 GLU A 398 43.925 76.689 107.365 00 19.79 A O
ATOM 2026 C GLU A 398 42.165 80.340 104.289 00 14.99 A C
ATOM 2027 O GLU A 398 42.906 81.328 104.457 00 14.48 A O
ATOM 2028 N ILE A 399 42.013 79.726 103.114 00 14.54 A N
ATOM 2029 CA ILE A 399 42.527 80.249 101.866 00 13.89 A C
ATOM 2030 CB ILE A 399 42.457 79.207 100.762 00 14.27 A C
ATOM 2031 CGl ILE A 399 43.422 78.040 101.000 00 15.69 A C
ATOM 2032 CDl ILE A 399 42.938 77.044 101.939 00 14.91 A C
ATOM 2033 CG2 ILE A 399 42.963 79.688 99.501 00 12.96 A C
ATOM 2034 C ILE A 399 41.828 81.485 101.480 00 14.39 A C
ATOM 2035 O ILE A 399 42.434 82.438 101.295 00 15.62 A O
ATOM 2036 N MET A 400 40.533 81.479 101.339 00 15.19 A N
ATOM 2037 CA MET A 400 39.795 82.662 101.021 00 15.67 A C
ATOM 2038 CB MET A 400 38.334 82.454 101.179 1.00 14.60 A C
ATOM 2039 CG MET A 400 37.804 81.460 100.197 1.00 15.55 A C
ATOM 2040 SD MET A 400 36.099 80.892 100.531 1.00 13.46 A S
ATOM 2041 CE MET A 400 35.416 82.291 100.255 1.00 14.71 A C
ATOM 2042 C MET A 400 40.102 83.936 101.844 1.00 15.95 A C
ATOM 2043 O MET A 400 39.826 85.081 101.278 1.00 16.18 A O
ATOM 2044 N ARG A 401 40.574 83.764 103.062 15.31 A N
ATOM 2045 CA ARG A 401 41.001 84.875 103.852 15.30 A C
ATOM 2046 CB ARG A 401 40.689 84.678 105.370 15.34 A C
ATOM 2047 CG ARG A 401 39.266 84.785 105.827 1.00 15.68 A C
ATOM 2048 CD ARG A '401 39.149 84.514 107.297 00 14.84 A C
ATOM 2049 NE ARG A 401 38.465 83.226 107.465 00 18.31 A N
ATOM 2050 CZ ARG A 401 38.966 82.287 108.103 00 17.84 A C
ATOM 2051 NHl ARG A 401 40.107 82.575 108.684 00 23.06 A N
ATOM 2052 NH2 ARG A 401 38.483 81.113 108.239 00 16.25 A N
ATOM 2053 C ARG A 401 42.507 85.183 103.856 1.00 15.84 A C
ATOM 2054 O ARG A 401 42.961 86.151 104.547 1.00 18.27 A O
ATOM 2055 N HIS A 402 43.308 84.366 103.193 1.00 15.35 A N
ATOM 2056 CA HIS A 402 44.789 84.625 103.070 1.00 14.76 A C
ATOM 2057 CB HIS A 402 45.478 83.431 102.494 1.00 13.00 A C
ATOM 2058 CG HIS A 402 46.949 83.502 102.498 1.00 15.61 A C
ATOM 2059 NDl HIS A 402 47.665 84.250 101.575 .00 15.27 A N
ATOM 2060 CEl HIS A 402 48.945 84.114 101.836 ,00 13.85 A C
ATOM 2061 NE2 HIS A 402 49.085 83.173 102.766 .00 14.61 A N
ATOM 2062 CD2 HIS A 402 47.862 82.797 103.203 .00 11.65 A C
ATOM 2063 C HIS A 402 45.069 85.926 102.334 .00 14.92 A C
ATOM 2064 O HIS A 402 44.398 86.246 101.371 ,00 15.59 A O
ATOM 2065 N SER A 403 46.014 86.714 102.874 .00 15.00 A N
ATOM 2066 CA SER A 403 46.387 88.060 102.310 ,00 15.60 A C
ATOM 2067 CB SER A 403 47.642 88.623 103.054 .00 14.73 A C
ATOM 2068 OG SER A 403 48.689 87.699 102.865 ,00 17.31 A O
ATOM 2069 C SER A 403 46.572 88.076 100.759 ,00 15.62 A C
ATOM 2070 O SER A 403 46.249 88.993 100.059 .00 17.22 A O
ATOM 2071 N PHE A 404 46.990 86.981 100.183 .00 15.35 A N
ATOM 2072 CA PHE A 404 47.067 86.873 98.686 .00 14.68 A C
ATOM 2073 CB PHE A 404 47.663 85.482 98.273 ,00 12.08 A C
ATOM 2074 CG PHE A 404 47.878 85.353 96.778 ,00 12.67 A C
ATOM 2075 CDl PHE A 404 48.986 85.856 96.245 ,00 14.50 A C
ATOM 2076 CEl PHE A 404 49.225 85.787 94.965 .00 14.22 A C
ATOM 2077 CZ PHE A 404 48.265 85.222 94.171 00 14.25 A C
ATOM 2078 CE2 PHE A 404 47.139 84.685 94.791 ,00 14.70 A C
ATOM 2079 CD2 PHE A 404 46.972 84.777 95.992 ,00 13.82 A C
ATOM 2080 C PHE A 404 45.686 87.039 97.973 1.00 13.12 A C
ATOM 2081 O PHE A 404 45.619 87.548 96.892 10.78 A O
ATOM 2082 N PHE A 405 44.579 86.623 98.610 12.54 A N
ATOM 2083 CA PHE A 405 43.242 86.880 98.013 12.63 A C
ATOM 2084 CB PHE A 405 42.450 85.607 98.097 9.13 A C
ATOM 2085 CG PHE A 405 43.002 84.508 97.300 7.72 A C
ATOM 2086 CDl PHE A 405 42.901 84.534 95.867 6.33 A C
ATOM 2087 CEl PHE A 405 43.338 83.385 95.127 6.69 A C
ATOM 2088 CZ PHE A 405 43.978 82.340 95.864 4.22 A C
ATOM 2089 CE2 PHE A 405 43.990 82.361 97.150 4.87 A C
ATOM 2090 CD2 PHE A 405 43.593 83.420 97.895 1.00 5.47 A C ATOM 2091 C PHE A 405 42.504 88.040 98.657 1.00 15.29 A C
ATOM 2092 O PHE A 405 41.273 88.143 98.655 1.00 17.33 A O
ATOM 2093 N SER A 406 43.274 88.937 99.264 1.00 16.09 A N
ATOM 2094 CA SER A 406 42.644 90.075 99.936 1.00 19.85 A C
ATOM 2095 CB SER A 406 43.678 90.854 100.867 1.00 19.87 A C
ATOM 2096 OG SER A 406 44.638 91.511 100.131 1.00 21.36 A O
ATOM 2097 C SER A 406 41.918 90.898 98.866 .00 21.23 A C
ATOM 2098 O SER A 406 42.299 90.977 .590 ,00 23.56 A O
ATOM 2099 N GLY A 407 40.873 91.562 .165 .00 20.93 A N
ATOM 2100 CA GLY A 407 40.452 92.094 .799 .00 21.13 A C
ATOM 2101 C GLY A 407 39.630 91.259 .755 .00 18.59 A C
ATOM 2102 O GLY A 407 39.088 91.809 .917 ,00 21.20 A O
ATOM 2103 N VAL A 408 39.446 89.968 .932 1.00 16.34 A N
ATOM 2104 CA VAL A 408 38.650 89.186 .089 1.00 13.53 A C
ATOM 2105 CB VAL A 408 39.230 87.815 .986 .00 12.94 A C
ATOM 2106 CGl VAL A 408 38.211 86.816 .348 .00 11.09 A C
ATOM 2107 CG2 VAL A 408 40.597 87.732 .239 .00 11.51 A C
ATOM 2108 C VAL A 408 37.270 89.080 .772 .00 13.20 A C
ATOM 2109 O VAL A 408 37.189 88..759 .952 .00 11.95 A O
ATOM 2110 N ASN A 409 36.209 89.393 .012 .00 13.33 A N
ATOM 2111 CA ASN A 409 34.848 89.162 .443 .00 13.38 A C
ATOM 2112 CB ASN A 409 33.849 90.105 .737 .00 14.95 A C
ATOM 2113 CG ASN A 409 32.447 89.984 .333 .00 14.77 A C
ATOM 2114 ODl ASN A 409 31.778 88.986 .086 .00 16.68 A O
ATOM 2115 ND2 ASN A 409 32.072 90.882 .178 .00 15.86 A N
ATOM 2116 C ASN A 409 34.514 87.759 .154 .00 13.24 A C
ATOM 2117 O ASN A 409 34.391 87.339 .981 .00 14.75 A O
ATOM 2118 N TRP A 410 34.393 86.962 .163 .00 12.37 A N
ATOM 2119 CA TRP A 410 34.166 85.544 .847 .00 14.68 A C
ATOM 2120 CB TRP A 410 34.408 84.636 .124 .00 13.15 A C
ATOM 2121 CG TRP A 410 35.816 84.722 .385 .00 13.43 A C
ATOM 2122 CDl TRP A 410 36.417 85.576 .214 .00 12.92 A C
ATOM 2123 NEl TRP A 410 37.782 85.383 .161 .00 15.40 A N
ATOM 2124 CE2 TRP A 410 38.096 84.424 .230 .00 14.98 A C
ATOM 2125 CD2 TRP A 410 36.873 83.969 .698 .00 16.35 A C
ATOM 2126 CE3 TRP A 410 36.876 82.866 .707 1.00 16.17 A C
ATOM 2127 CZ3 TRP A 410 38.109 82.341 .316 .00 18.51 A C
ATOM 2128 CH2 TRP A 410 39.360 82.926 .919 .00 20.00 A C
ATOM 2129 CZ2 TRP A 410 39.323 83.937 .847 .00 15.46 A C
ATOM 2130 C TRP A 410 32.874 85.159 .171 ,00 14.87 A C
ATOM 2131 O TRP A 410 32.861 84.206 .409 ,00 11.61 A O
ATOM 2132 N GLN A 411 31.747 85.868 .488 .00 18.02 A N
ATOM 2133 CA GLN A 411 30.400 85.639 .777 ,00 17.35 A C
ATOM 2134 CB GLN A 411 29.319 86.545 .445 ,00 18.86 A C
ATOM 2135 CG GLN A 411 27.939 85.840 .991 .00 23.20 A C
ATOM 2136 CD GLN A 411 27.631 84.553 .365 .00 24.75 A C
ATOM 2137 OEl GLN A 411 28.221 83.597 .774 1.00 27.36 A O
ATOM 2138 NE2 GLN A 411 27.070 84.558 .225 24.78 A N
ATOM 2139 C GLN A 411 30.570 86.012 .349 15.10 A C
ATOM 2140 O GLN A 411 30.083 85.370 .433 15.74 A O
ATOM 2141 N ASP A 412 31.353 87.064 .106 14.60 A N
ATOM 2142 CA ASP A 412 31.739 87.389 .709 16.79 A C
ATOM 2143 CB ASP A 412 32.486 88-710 .567 15.76 A C
ATOM 2144 CG ASP A 412 31.579 89.900 .676 16.57 A C
ATOM 2145 ODl ASP A 412 30.302 89.762 .628 13.85 A O
ATOM 2146 OD2 ASP A 412 32.177 91.022 .860 22.14 A O
ATOM 2147 C ASP A 412 32.479 86.301 .922 16.96 A C
ATOM 2148 O ASP A 412 32.265 86.149 .678 1.00 18.87 A O
ATOM 2149 N VAL A 413 33.295 85.551 .624 ,00 15.91 A N
ATOM 2150 CA VAL A 413 34.049 84.534 .922 ,00 16.27 A C
ATOM 2151 CB VAL A 413 35.123 83.865 .808 ,00 17.12 A C
ATOM 2152 CGl VAL A 413 35.733 82.666 .174 1.00 14.92 A C
ATOM 2153 CG2 VAL A 413 36.241 84.925 .171 .00 14.08 A C
ATOM 2154 C VAL A 413 33.023 83.526 .388 .00 14.95 A C
ATOM 2155 O VAL A 413 33.032 83.225 .262 .00 14.56 A O
ATOM 2156 N TYR A 414 32.258 83.036 .335 .00 16.67 A N
ATOM 2157 CA TYR A 414 31.182 82.034 .126 .00 19.18 A C
ATOM 2158 CB TYR A 414 30.411 81.746 .422 .00 18.92 A C
ATOM 2159 CG TYR A 414 29.432 80.668 .212 .00 21.54 A C
ATOM 2160 CDl TYR A 414 29.818 79.300 .330 .00 22.98 A C
ATOM 2161 CEl TYR A 414 28.899 78.267 .045 .00 23.70 A C
ATOM 2162 CZ TYR A 414 27.621 78.610 .653 .00 23.97 A C
ATOM 2163 OH TYR A 414 26.693 77.628 .465 1.00 25.45 A O ATOM 2164 CK2 TYR A 414 27.186 79.938 92.612 1.00 21.86 A C
ATOM 2165 CD2 TYR A 414 28.109 80.951 92.846 1.00 20.47 A C
ATOM 2165 C TYR A 414 30.185 82.464 90.938 1.00 19.95 A C
ATOM 2167 O TYR A 414 30.034 81.666 89.997 1.00 18.74 A O
ATOM 2168 N ASP A 415 29.731 83.749 90.914 1.00 20.17 A N
ATOM 2169 CA ASP A 415 28.840 84.268 89.864 1.00 19.82 A C
ATOM 2170 CB ASP A 415 28.112 85.497 90.310 1.00 19.65 A C
ATOM 2171 CG ASP A 415 27.246 85.259 91.571 1.00 19.13 A C
ATOM 2172 ODl ASP A 415 26.840 84.140 91.819 1.00 21.35 A O
ATOM 2173 OD2 ASP A 415 27.086 86.108 92.388 1.00 18.93 A O
ATOM 2174 C ASP A 415 29.471 84.683 88.569 1.00 22.07 A C
ATOM 2175 O ASP A 415 28.800 85.212 87.657 1.00 23.02 A O
ATOM 2176 N LYS A 416 30.799 84.499 88.496 1.00 22.31 A N
ATOM 2177 CA LYS A 416 31.622 84.753 87.365 1.00 21.30 A C
ATOM 2178 CB LYS A 416 31.251 83.880 86.185 1.00 21.70 A C
ATOM 2179 CG LYS A 416 31.512 82.418 86.528 1.00 21.49 A C
ATOM 2180 CD LYS A 416 31.480 81.638 85.202 1.00 22.95 A C
ATOM 2181 CE LYS A 416 30.109 81.483 84.554 1.00 22.95 A C
ATOM 2182 NZ LYS A 416 30.294 80.895 83.157 1.00 23.40 A N
ATOM 2183 C LYS A 416 31.636 86.186 86.994 1.00 20.69 A C
ATOM 2184 O LYS A 416 31.627 86.530 85.838 1.00 20.81 A O
ATOM 2185 N LYS A 417 31.652 87.031 87.964 1.00 22.28 A N
ATOM 2186 CA LYS A 417 31.656 88.436 87.658 1.00 22.69 A C
ATOM 2187 CB LYS A 417 30.767 89.114 88.683 1.00 23.23 A C
ATOM 2188 CG LYS A 417 29.213 88.975 88.386 1.00 21.94 A C
ATOM 2189 CD LYS A 417 28.442 89.698 89.495 1.00 23.69 A C
ATOM 2190 CE LYS A 417 26.894 89.289 89.672 1.00 22.83 A C
ATOM 2191 NZ LYS A 417 26.320 89.919 91.033 1.00 19.99 A N
ATOM 2192 C LYS A 417 33.063 89.142 87.636 1.00 24.32 A C
ATOM 2193 O LYS A 417 33.081 90.323 87.424 1.00 24.38 A O
ATOM 2194 N LEU A 418 34.149 88.508 88.067 1.00 24'.71 A N
ATOM 2195 CA LEU A 418 35.467 89.034 87.907 1.00 25.36 A C
ATOM 2196 CB LEU A 418 36.483 88.180 88.568 1.00 26.72 A C
ATOM 2197 CG LEU A 418 37.077 88.398 89.977 1.00 28.36 A C
ATOM 2198 CDl LEU A 418 36.119 88.624 91.032 1.00 29.77 A C
ATOM 2199 CD2 LEU A 418 37.964 87.242 90.367 1.00 30.32 A C
ATOM 2200 C LEU A 418 35.821 88.964 86.369 1.00 25.76 A C
ATOM 2201 O LEU A 418 35.488 88.047 85.682 1.00 24.99 A O
ATOM 2202 N VAL A 419 36.612 89.903 85.883 1.00 26.36 A N
ATOM 2203 CA VAL A 419 37.088 89.881 84.502 1.00 25.41 A C
ATOM 2204 CB VAL A 419 37.518 91.274 84.070 1.00 25.92 A C
ATOM 2205 CGl VAL A 419 37.641 91.285 82.447 1.00 24.71 A C
ATOM 2206 CG2 VAL A 419 36.491 92.233 84.609 1.00 26.21 A C
ATOM 2207 C VAL A 419 38.276 88.934 84.332 1.00 24.37 A C
ATOM 2208 O VAL A 419 39.348 89.181 84.867 1.00 23.22 A O
ATOM 2209 N PRO A 420 38.068 87.877 83.535 1.00 23.27 A N
ATOM 2210 CA PRO A 420 39.167 86.993 83.195 1.00 22.71 A C
ATOM 2211 CB PRO A 420 38.555 86.030 82.305 1.00 22.47 A C
ATOM 2212 CG PRO A 420 37.017 86.175 82.510 1.00 21.87 A C
ATOM 2213 CD PRO A 420 36.791 87.515 82.867 1.00 22.61 A C
ATOM 2214 C PRO A 420 40.341 87.797 82.488 1.00 23.25 A C
ATOM 2215 O PRO A 420 40.096 88.685 81.738 1.00 22.69 A O
ATOM 2216 N PRO A 421 41.574 87.474 82.811 1.00 24.07 A N
ATOM 2217 CA PRO A 421 42.765 88.180 82.367 1.00 24.22 A C
ATOM 2218 CB PRO A 421 43.866 87.740 83.412 1.00 24.84 . A C
ATOM 2219 CG PRO A 421 43.385 86.295 83.700 1.00 25.74 A C
ATOM 2220 CD PRO A 421 41.882 86.444 83.808 1.00 23.97 A C
ATOM 2221 C PRO A 421 43.132 87.718 81.004 1.00 24.92 A C
ATOM 2222 O PRO A 421 43.910 88.454 80.371 1.00 24.96 A O
ATOM 2223 N PHE A 422 42.550 86.599 80.546 1.00 24.89 A N
ATOM 2224 CA PHE A 422 42.794 86.155 79.216 1.00 25.37 A C
ATOM 2225 CB PHE A 422 43.792 85.019 79.184 1.00 25.50 A C
ATOM 2226 CG PHE A 422 43.976 84.390 77.791 1.00 26.73 A C
ATOM 2227 CDl PHE A 422 44.635 85.102 76.742 1.00 28.33 A C
ATOM 2228 CEl PHE A 422 44.810 84.482 75.400 1.00 28.12 A C
ATOM 2229 CZ PHE A 422 44.323 83.172 75.190 1.00 27.48 A C
ATOM 2230 CE2 PHE A 422 43.659 82.492 76.306 1.00 28.21 A C
ATOM 2231 CD2 PHE A 422 43.508 83.069 77.531 1.00 26.35 A C
ATOM 2232 C PHE A 422 41.537 85.656 78.693 1.00 26.90 A C
ATOM 2233 O PHE A 422 41.031 84.682 79.250 1.00 25.69 A O
ATOM 2234 N LYS A 423 41.146 86.193 77.517 1.00 27.97 A N
ATOM 2235 CA LYS A 423 39.916 85.909 76.907 1.00 29.50 A C
ATOM 2236 CB LYS A 423 39.195 87.195 76.558 1.00 28.00 A C ATOM 2237 CG LYS A 423 38.127 86.964 75.416 1.00 28.38 A C
ATOM 2238 CD LYS A 423 37.030 85.940 75.848 1.00 29.10 A C
ATOM 2239 CE LYS A 423 35.853 85.888 74.828 1.00 30.00 A C
ATOM 2240 NZ LYS A 423 36.096 84.771 73.754 1.00 30.38 A N
ATOM 2241 C LYS A 423 40.226 85.032 75.651 1.00 30.48 A C
ATOM 2242 O LYS A 423 41.012 85.437 74.735 1.00 30.60 A O
ATOM 2243 N PRO A 424 39.706 83.795 75.644 1.00 30.83 A N
ATOM 2244 CA PRO A 424 40.043 82.905 74.554 1.00 32.30 A C
ATOM 2245 CB PRO A 424 39.477 81.530 75.017 1.00 32.34 A C
ATOM 2246 CG PRO A 424 39.209 81.705 76.457 1.00 28.45 A C
ATOM 2247 CD PRO A 424 38.845 83.113 76.628 1.00 30.05 A C
ATOM 2248 C PRO A 424 39.459 83.418 73.237 1.00 33.23 A C
ATOM 2249 O PRO A 424 38.287 83.847 73.173 1.00 32.41 A O
ATOM 2250 N GLN A 425 40.343 83.386 72.219 1.00 34.64 A N
ATOM 2251 CA GLN A 425 40.017 83.887 70.864 1.00 36.31 A C
ATOM 2252 CB GLN A 425 41.255 84.542 70.237 1.00 36.59 A C
ATOM 2253 CG GLN A 425 41.656 85.750 71.151 1.00 35.69 A C
ATOM 2254 CD GLN A 425 40.779 86.893 70.898 1.00 35.83 A C
ATOM 225S OEl GLN A 425 40.688 87.325 69.722 1.00 37.21 A O
ATOM 2256 NE2 GLN A 425 40.134 87.422 71.921 1.00 34.85 A N
ATOM 2257 C GLN A 425 39.375 82.799 69.967 1.00 36.90 A C
ATOM 2258 O GLN A 425 40.061 82.115 69.173 1.00 37.01 A O
ATOM 2259 N VAL A 426 38.045 82.650 70.158 1.00 36.63 A N
ATOM 2260 CA VAL A 426 37.236 81.633 69.485 1.00 36.97 A C
ATOM 2261 CB VAL A 426 36.655 80.500 70.503 1.00 35.94 A C
ATOM 2262 CGl VAL A 426 37.791 79.692 71.201 1.00 34.28 A C
ATOM 2263 CG2 VAL A 426 35.672 81.095 71.582 1.00 35.48 A C
ATOM 2264 C VAL A 426 36.168 82.471 68.797 1.00 37.47 A C
ATOM 2265 O VAL A 426 35.529 83.225 69.480 1.00 39.42 A O
ATOM 2266 N THR A 427 35.965 82.331 67.485 1.00 38.01 A N
ATOM 2267 CA THR A 427 35.007 83.126 66.768 1.00 38.97 A C
ATOM 2268 CB THR A 427 35.281 83.090 65.256 1.00 40.28 A C
ATOM 2269 OGl THR A 427 34.643 81.933 64.645 1.00 41.12 A O
ATOM 2270 CG2 THR A 427 36.811 82.894 64.948 1.00 41.20 A C
ATOM 2271 C THR A 427 33.632 82.532 66.960 1.00 39.22 A C
ATOM 2272 O THR A 427 32.701 82.919 66.200 1.00 40.60 A O
ATOM 2273 N SER A 428 33.478 81.576 6T.899 1.00 37.77 A N
ATOM 2274 CA , SER A 428 32.270 80.737 67.845 1.00 37.03 A C
ATOM 2275 CB SER A 428 32.112 80.169 66.380 1.00 36.77 A C
ATOM 2276 OG SER A 428 32.307 78.776 66.291 1.00 34.05 A O
ATOM 2277 C SER A 428 32.201 79.637 68.910 1.00 36.13 A C
ATOM 2278 O SER A 428 33.095 79.389 69.725 1.00 37.06 A O
ATOM 2279 N GLU A 429 31.108 78.949 68.893 1.00 34.31 A N
ATOM 2280 CA GLU A 429 30.730 78.075 70.010 1.00 33.66 A C
ATOM 2281 CB GLU A 429 29.205 77.866 69.902 1.00 33.73 A C
ATOM 2282 CG GLU A 429 28.686 77.272 71.193 1.00 34.94 A C
ATOM 2283 CD GLU A 429 27.200 77.089 71.226 1.00 35.71 A C
ATOM 2284 OEl GLU A 429 26.745 76.066 71.853 1.00 36.03 A O
ATOM 2285 OE2 GLU A 429 26.545 77.976 70.688 1.00 35.22 A O
ATOM 2286 C GLU A 429 31.378 76.710 69.904 1.00 32.15 A C
ATOM 2287 O GLU A 429 31.809 75.989 70.893 1.00 31.66 A O
ATOM 2288 N THR A 430 31.456 76.384 68.636 1.00 30.47 A N
ATOM 2289 CA THR A 430 32.117 75.206 68.227 1.00 29.47 A C
ATOM 2290 CB THR A 430 31.351 74.543 67.117 1.00 30.30 A C
ATOM 2291 OGl THR A 430 31.257 75.473 66.019 1.00 29.71 A O
ATOM 2292 CG2 THR A 430 29.991 74.207 67.517 1.00 30.99 A C
ATOM 2293 C THR A 430 33.488 75.418 67.704 1.00 28.76 A C
ATOM 2294 O THR A 430 33.987 74.468 67.124 1.00 30.01 A O
ATOM 2295 N ASP A 431 34.112 76.605 67.873 1.00 27.08 A N
ATOM 2296 CA ASP A 431 35.389 76.838 67.233 1.00 26.63 A C
ATOM 2297 CB ASP A 431 35.860 78.206 67.574 1.00 24.64 A C
ATOM 2298 CG ASP A 431 37.165 78.503 67.070 1.00 23.13 A C
ATOM 2299 ODl ASP A 431 37.560 79.678 66.940 1.00 26.40 A O
ATOM 2300 OD2 ASP A 431 38.016 77.705 66.984 1.00 20.39 A O
ATOM 2301 C ASP A 431 36.467 75.735 67.333 1.00 27.39 A C
ATOM 2302 O ASP A 431 37.030 75.321 66.306 1.00 31.94 A O
ATOM 2303 N THR A 432 36.830 75.125 68.419 1.00 26.48 A N
ATOM 2304 CA THR A 432 37.936 74.078 68.201 1.00 25.79 A C
ATOM 2305 CB THR A 432 37.562 72.899 67.208 1.00 25.87 A C
ATOM 2306 OGl THR A 432 37.959 73.216 65.862 1.00 27.96 A O
ATOM 2307 CG2 THR A 432 36.057 72.607 67.127 1.00 25.94 A C
ATOM 2308 C THR A 432 39.394 74.472 67.863 1.00 25.43 A C
ATOM 2309 O THR A 432 40.328 73.631 67.984 1.00 23.57 A O ATOM 2310 N ARG A 433 39.621 75.734 67.480 1.00 25.49 A N
ATOM 2311 CA ARG A 433 40.948 76.177 S7.198 1.00 26.15 A C
ATOM 2312 CB ARG A 433 40.959 77.668 66.975 1.00 26.53 A C
ATOM 2313 CG ARG A 433 41.022 78.569 68.226 1.00 25.91 A C
ATOM 2314 CD ARG A 433 41.447 79.893 67.877 1.00 28.63 A C
ATOM 2315 NE ARG A 433 40.322 80.604 67.186 1.00 30.91 A N
ATOM 2316 CZ ARG A 433 40.204 80.829 65.872 1.00 31.59 A C
ATOM 2317 NHl ARG A 433 41.152 80.515 65.015 1.00 31.16 A N
ATOM 2318 NH2 ARG A 433 39.177 81.449 65.383 1.00 31.84 A N
ATOM 2319 C ARG A 433 41.952 75.751 68.316 1.00 29.18 A C
ATOM 2320 O ARG A 433 43.065 75.286 67.959 1.00 30.26 A O
ATOM 2321 N TYR A 434 41.660 75.843 69.638 1.00 29.13 A N
ATOM 2322 CA TYR A 434 42.629 75.328 70.654 1.00 30.30 A C
ATOM 2323 CB TYR A 434 42.235 75.806 72.069 1.00 28.91 A C
ATOM 2324 CG TYR A 434 42.296 77.346 72.135 1.00 28.22 A C
ATOM 2325 CDl TYR A 434 43.508 77.984 72.172 1.00 28.15 A C
ATOM 2326 CEl TYR A 434 43.584 79.326 72.197 1.00 28.43 A C
ATOM 2327 CZ TYR A 434 42.518 80.097 72.103 1.00 28.17 A C
ATOM 2328 OH TYR A 434 42.745 81.446 72.101 1.00 31.38 A O
ATOM 2329 CE2 TYR A 434 41.304 79.575 71.981 1.00 28.83 A C
ATOM 2330 CD2 TYR A 434 41.178 78.127 72.002 1.00 28.65 A C
ATOM 2331 C TYR A 434 42.893 73.833 70.678 1.00 32.26 A C
ATOM 2332 O TYR A 434 43.759 73.306 71.385 1.00 32.10 A O
ATOM 2333 N PHE A 435 42.179 73.117 69.813 1.00 35.44 A N
ATOM 2334 CA PHE A 435 42.455 71.714 69.578 1.00 37.49 A C
ATOM 2335 CB PHE A 435 41.122 70.940 69.553 1.00 35.78 A C
ATOM 2336 CG PHE A 435 40.388 71.030 70.833 1.00 33.58 A C
ATOM 2337 CDl PHE A 435 39.429 71.987 71.031 1.00 34.25 A C
ATOM 2338 CEl PHE A 435 38.736 72.105 72.207 1.00 33.45 A C
ATOM 2339 CZ PHE A 435 39.040 71.312 73.222 1.00 33.02 A C
ATOM 2340 CE2 PHE A 435 40.013 70.327 73.069 1.00 32.72 A C
ATOM 2341 CD2 PHE A 435 40.696 70.218 71.905 1.00 33.15 A C
ATOM 2342 C PHE A 435 43.465 71.435 68.438 1.00 40.27 A C
ATOM 2343 O PHE A 435 43.767 70.293 68.252 1.00 39.68 A O
ATOM 2344 N ASP A 436 44.029 72.468 67.771 1.00 44.43 A N
ATOM 2345 CA ASP A 436 45.490 72.478 67.259 1.00 47.33 A C
ATOM 2346 CB ASP A 436 46.448 73.081 68.401 1.00 46.84 A C
ATOM 2347 CG ASP A 436 46.830 74.542 68.211 1.00 45.97 A C
ATOM 2348 ODl ASP A 436 46.560 75.105 67.145 1.00 46.83 A O
ATOM 2349 OD2 ASP A 436 47.411 75.219 69.074 1.00 45.85 A O
ATOM 2350 C ASP A 436 46.160 71.102 66.911 1.00 50.06 A C
ATOM 2351 O ASP A 436 46.411 70.299 67.857 1.00 51.20 A O
ATOM 2352 N GLU A 437 46.585 70.851 65.649 1.00 52.95 A N
ATOM 2353 CA GLU A 437 46.936 69.458 65.121 1.00 54.81 A C
ATOM 2354 CB GLU A 437 48.327 68.898 65.567 1.00 55.01 A C
ATOM 2355 CG GLU A 437 49.479 69.846 65.632 1.00 53.30 A C
ATOM 2356 CD GLU A 437 49.286 70.906 66.684 1.00 53.63 A C
ATOM 2357 OEl GLU A 437 48.518 70.700 67.662 1.00 51.72 A O
ATOM 2358 OE2 GLU A 437 49.927 71.969 66.495 1.00 53.68 A O
ATOM 2359 C GLU A 437 45.897 68.347 65.463 1.00 55.95 A C
ATOM 2360 O GLU A 437 46.014 67.687 66.558 1.00 55.65 A O
ATOM 2361 N GLU A 438 44.913 68.156 64.540 1.00 57.21 A N
ATOM 2362 CA GLU A 438 43.897 67.034 64.585 1.00 58.31 A C
ATOM 2363 CB GLU A 438 42.633 67.521 65.336 1.00 57.49 A C
ATOM 2364 CG GLU A 438 42.701 67.372 66.857 1.00 56.55 A C
ATOM 2365 CD GLU A 438 43.250 65.995 67.330 1.00 56.80 A C
ATOM 2366 OEl GLU A 438 43.299 65.014 66.552 1.00 57.24 A O
ATOM 2367 OE2 GLU A 438 43.640 65.877 68.502 1.00 57.50 A O
ATOM 2368 C GLU A 438 43.541 66.265 63.209 1.00 59.59 A C
ATOM 2369 O GLU A 438 43.275 66.885 62.142 1.00 59.52 A O
ATOM 2370 N PHE A 439 43.571 64.920 63.263 1.00 60.59 A N
ATOM 2371 CA PHE A 439 43.251 64.007 62.110 1.00 61.40 A C
ATOM 2372 CB PHE A 439 44.089 64.334 60.818 1.00 61.63 A C
ATOM 2373 CG PHE A 439 43.855 63.355 59.614 1.00 61.73 A C
ATOM 2374 CDl PHE A 439 44.941 62.607 59.068 1.00 61.43 A C
ATOM 2375 CEl PHE A 439 44.757 61.729 57.995 1.00 61.38 A C
ATOM 2376 CZ PHE A 439 43.465 61.549 57.446 1.00 61.68 A C
ATOM 2377 CE2 PHE A 439 42.345 62.301 57.963 1.00 61.13 A C
ATOM 2378 CD2 PHE A 439 42.551 63.193 59.028 1.00 61.79 A C
ATOM 2379 C PHE A 439 43.466 62.502 62.570 1.00 62.06 A C
ATOM 2380 O PHE A 439 42.603 61.596 62.277 1.00 62.36 A O
ATOM 2381 OXT PHE A 439 44.491 62.120 63.248 1.00 62.01 A O
ATOM 2382 CIJI INH B 1 47.275 64.439 78.188 1.00 55.75 CL ATOM 2383 C2 INH B 1 35.626 69.954 75.530 .00 34.60 C
ATOM 2384 S3 INH B 1 39.212 67.114 75.139 .00 45.46 S
ATOM 2385 C4 INH B 1 36.720 69.115 75.348 .00 37.27 C
ATOM 2386 C5 INH B 1 37.006 68.274 76.434 .00 38.69 C
ATOM 2387 N6 INH B 1 36.252 68.284 77.591 .00 36.76 N
ATOM 2388 C7 INH B 1 35.209 69.140 77.658 1.00 34.30 C
ATOM 2389 N8 INH B 1 34.864 69.989 76.657 1.00 34.21 N
ATOM 2390 N9 ,IHH B 1 34.462 69.151 78.816 1.00 32.74 N
ATOM 2391 ClO INH B 1 38.121 67.313 76.470 1 00 41.55 C
ATOM 2392 CIl INH B 1 38.472 66.453 77.506 1 00 43.69 C
ATOM 2393 C12 INH B 1 39.603 65.653 77.214 1 00 45.56 C
ATOM 2394 Cl3 INH B 1 40.124 65.898 75.952 1 00 46.77 C
ATOM 2395 C14 INH B 1 41.262 65.268 75.279 1 00 49.13 C
ATOM 2396 015 INH B 1 41.158 64.818 74.160 1 00 50.99 O
ATOM 2397 Nie INH B 1 42.404 65.199 76.040 1 00 52.16 N
ATOM 2398 C17 INH B 1 43.611 64.600 75.716 1 00 54.57 C
ATOM 2399 N18 INH B 1 44.637 64.632 76.576 1 00 55.19 N
ATOM 2400 C19 INH B 1 45.727 63.938 76.057 1 00 55.20 C
ATOM 2401 C20 INH B 1 45.498 63.372 74.768 1 00 54.85 C
ATOM 2402 S21 INH B 1 43.885 63.763 74.242 1 00 54.17 S
ATOM 2403 C22 INH B 1 46.495 62.611 74.079 1 00 54.94 C
ATOM 2404 C23 INH B 1 47.769 62.407 74.705 1 00 55.61 C
ATOM 2405 C24 INH B 1 48.812 61.597 74.000 1 00 56.27 C
ATOM 2406 N25 INH B 1 48.478 60.143 74.047 1 00 56.42 N
ATOM 2407 C26 INH B 1 48.033 62.972 75.992 1 00 55.50 C
ATOM 2408 C27 INH B 1 47.021 63.729 76.653 1 00 55.86 C
ATOM 2409 03 GOL C 1 28.183 79.475 98.039 1 00 36.99 C O
ATOM 2410 C3 GOL C 1 28.022 78.135 97.471 1 00 38.57 C C
ATOM 2411 C2 GOL C 1 29.096 77.171 96.784 1 00 37.40 C C
ATOM 2412 02 GOL C 1 28.663 75.795 96.858 1 00 34.82 C O
ATOM 2413 Cl GOL C 1 30.697 77.251 96.953 1 00 37.76 C C
ATOM 2414 Ol GOL C 1 31.415 77.117 95.679 1 00 33.06 C O
ATOM 2415 O HOH W 1 35.690 61.947 98.073 1 00 20.85 W O
ATOM 2416 O HOH W 2 38.234 64.790 104.049 1 00 26.23 W O
ATOM 2417 O HOH W 3 38.985 87.872 100.138 1 00 14.11 W O
ATOM 2418 O HOH W 4 43.244 89.658 96.081 1 00 7.40 W O
ATOM 2419 O HOH W 5 29.453 71.376 87.192 1.00 25.89 W O
ATOM 2420 O HOH W 6 50.194 89.264 93.892 1.00 18.69 W O
ATOM 2421 O HOH W 7 39.987 76.043 109.525 1.00 24.25 W O
ATOM 2422 O HOH W 8 37.319 67.174 87.549 1.00 34.93 W O
ATOM 2423 O HOH W 9 34.472 84.504 88.439 1.00 16.40 W O
ATOM 2424 O HOH W 10 54.160 85.298 88.301 1.00 11.14 W O
ATOM 2425 O HOH W 11 44.596 64.598 104.465 1.00 27.90 W O
ATOM 2426 O HOH W 12 41.750 87.373 101.706 1.00 12.50 W O
ATOM 2427 O HOH W 13 62.333 69.882 92.005 1.00 18.17 W O
ATOM 2428 O HOH W 14 43.514 67.281 94.203 1.00 10.48 W O
ATOM 2429 O HOH W 15 31.653 81.508 81.071 1.00 22.92 W O
ATOM 2430 O HOH W 16 41.285 90.999 84.636 1.00 29.49 W O
ATOM 2431 O HOH W 17 34.736 92.484 92.897 .00 32.44 W O
ATOM 2432 O HOH W 18 57.303 71.849 100.958 .00 21.69 W O
ATOM 2433 O HOH W 19 28.256 88.305 92.944 .00 17.47 W O
ATOM 2434 O HOH W 20 24.681 75.964 66.389 .00 30.36 W O
ATOM 2435 O HOH W 21 36.686 90.428 93.491 .00 16.41 W O
ATOM 2436 O HOH W 22 34.899 74.361 102.062 .00 13.24 W O
ATOM 2437 O HOH W 23 27.025 70.670 101.958 .00 24.59 W O
ATOM 2438 O HOH W 24 39.337 73.860 75.772 .00 34.64 W O
ATOM 2439 O HOH W 25 55.813 69.319 91.683 .00 39.01 W O
ATOM 2440 O HOH W 26 32.391 80.127 96.517 .00 33.79 W O
ATOM 2441 O HOH W 27 49.429 68.202 85.006 .00 25.89 W O
ATOM 2442 O HOH W 28 48.146 90.029 97.621 .00 17.74 W O
ATOM 2443 O HOH W 29 38.319 63.230 87.066 .00 30.62 W O
ATOM 2444 O HOH W 30 34.202 75.866 105.497 .00 33.11 W O
ATOM 2445 O HOH W 31 23.768 53.646 67.786 .00 36.73 W O
ATOM 2446 O HOH W 32 46.569 66.640 95.344 1.00 36.47 W O
ATOM 2447 O HOH W 33 41.336 83.724 81.360 1.00 21.73 W O
ATOM 2448 O HOH W 34 51.830 71.458 64.978 1.00 33.94 W O
ATOM 2449 O HOH W 35 47.413 71.003 70.219 1.00 32.48 W O
ATOM 2450 O HOH W 35 29.216 73.865 85.101 1.00 30.83 W O
ATOM 2451 O HOH W 37 43.782 67.051 107.679 1.00 35.19 W O
ATOM 2452 O HOH W 38 45.169 75.097 109.099 1.00 24.84 W O
ATOM 2453 O HOH W 39 31.988 55.882 96.415 1.00 30.59 W O
ATOM 2454 O HOH W 40 42.319 66.980 105.622 1.00 20.16 W O
ATOM 2455 O HOH W 41 39.370 76.112 70.357 1.00 9.55 W O ATOM 2456 O HOH W 42 49.603 86.689 82.331 1.00 19.35 W O
ATOM 2457 O HOH W 43 30.049 56.002 87.505 1.00 29.02 W O
ATOM 2458 O HOH W 44 44.127 54.141 72.291 1.00 39.03 W O
ATOM 2459 O HOH W 45 17.780 59.772 63.850 1.00 43.18 W O
ATOM 2460 O HOH W 46 35.945 83.904 106.884 1.00 23.61 W O
ATOM 2461 O HOH W 47 42.498 52.153 68.724 1.00 34.90 W O
ATOM 2462 O HOH W 48 46.552 86.095 105.234 1.00 33.45 W O
ATOM 2463 O HOH W 49 30.483 57.891 96.728 1.00 37.32 W O
ATOM 2464 O HOH W 50 33.295 78.844 83.728 1.00 25.76 W O
ATOM 2465 O HOH W 51 50.755 54.614 100.747 1.00 36.56 W O
ATOM 2466 O HOH W 52 51.019 87.108 104.279 1.00 25.93 W O
ATOM 2467 O HOH W 53 ' 53.966 67.056 94.736 1.00 36.30 W O
ATOM 2468 O HOH W 54 66.104 54.612 93.315 1.00 61.66 W O
ATOM 2469 O HOH W 55 24.875 74.050 72.704 1.00 23.65 W O
ATOM 2470 O HOH W 56 28.315 72.235 75.052 1.00 40.05 W O
ATOM 2471 O HOH W 57 50.366 81.314 104.006 1.00 37.76 W O
ATOM 2472 O HOH W 58 65.663 73.175 100.265 1.00 28.91 W O
ATOM 2473 O HOH W 59 34.084 87.866 99.821 1.00 15.91 W O
ATOM 2474 O HOH W 60 29.812 78.318 84.418 1.00 30.63 W O
ATOM 247B O HOH W 61 45.044 64.443 69.928 1.00 32.96 W O
ATOM 2476 O HOH W 62 40.925 59.623 88.123 1.00 45.15 W O
ATOM 2477 O HOH W 63 44.711 67.615 76.709 1.00 25.01 W O
ATOM 2478 O HOH W 64 66.373 87.296 90.616 1.00 31.05 W O
ATOM 2479 O HOH W 65 29.800 82.426 98.109 1.00 30.44 W O
ATOM 2480 O HOH W 66 21.748 75.461 78.086 1.00 40.69 W O
ATOM 2481 O HOH W 67 45.193 78.265 66.995 1.00 26.00 W O
ATOM 2482 O HOH W 68 51.829 76.729 68.123 1.00 35.26 W O
ATOM 2483 O HOH W 69 27.642 61.925 62.449 1.00 25.33 W O
ATOM 2484 , O HOH W 70 43.504 52.936 97.632 1.00 38.32 W O
ATOM 2485 O HOH W 71 28.220 91.580 92.498 1.00 18.75 W O
ATOM 2486 O HOH W 72 58.947 61.870 87.565 1.00 38.16 W O
ATOM 2487 O HOH W 73 44.107 82.314 106.467 1.00 16.73 W O
ATOM 2488 O HOH W 74 53.261 53.380 106.653 1.00 38.27 W O
ATOM 2489 O HOH W 75 22.908 74.586 69.906 1.00 37.80 W O
ATOM 2490 O HOH W 76 47.349 92.102 101.413 1.00 26.51 W O
ATOM 2491 O HOH W 77 21.352 54.981 80.918 1.00 41.18 W O
ATOM 2492 O HOH W 78 27.230 75.214 92.964 1.00 28.98 W O
ATOM 2493 O HOH W 79 62.785 76.354 87.386 1.00 44.92 W O
ATOM 2494 O HOH W 80 19.118 64.179 80.227 1.00 36.12 W O
ATOM 2495 O HOH W 81 35.445 63.533 89.580 1.00 39.59 W O
ATOM 2496 O HOH W 82 48.937 74.002 66.316 1.00 42.10 W O
ATOM 2497 O HOH W 83 44.054 55.886 87.763 1.00 37.79 W O
ATOM 2498 O HOH W 84 52.565 64.316 105.692 1.00 28.46 W O
ATOM 2499 O HOH W 85 39.094 58.829 81.837 1.00 43.30 W O
ATOM 2500 O HOH W 86 50.570 59.308 106.253 1.00 32.97 W O
ATOM 2501 O HOH W 87 54.281 61.941 108.664 1.00 39.16 W O
ATOM 2502 O HOH W 88 43.180 88.585 76.684 1.00 41.98 W O
ATOM 2503 O HOH W 89 32.819 79.298 108.493 1.00 30.70 W O
ATOM 2504 O HOH W 90 48.081 64.176 95.847 1.00 42.80 W O
ATOM 2505 O HOH W 91 53.909 82.178 72.497 1.00 26.90 W O
ATOM 2506 O HOH W 92 63.343 59.635 79.976 1.00 24.09 W O
ATOM 2507 O HOH W 93 24.887 70.583 95.258 1.00 23.92 W O
ATOM 2508 O HOH W 94 56.748 53.955 91.215 1.00 43.92 W O
ATOM 2509 O HOH W 95 20.329 67.093 63.779 1.00 46.61 W O
ATOM 2510 O HOH W 96 63.328 57.584 84.795 1.00 35.25 W O
ATOM 2511 O HOH W 97 64.875 83.799 91.339 1.00 24.30 W O
ATOM 2512 O HOH W 98 33.062 75.705 63.895 1.00 32.45 W O
ATOM 2513 O HOH W 99 23.707 71.172 85.026 1.00 40.89 W O
ATOM 2514 O HOH W 100 44.816 91.320 81.169 1.00 29.16 W O
ATOM 2515 O HOH W 101 33.796 81.438 95.235 1.00 38.32 W O
ATOM 2516 O HOH W 102 45.548 90.352 84.770 1.00 49.61 W O
ATOM 2517 O HOH W 103 29.359 62.956 94.439 1.00 48.20 W O
ATOM 2518 O HOH W 104 42.073 88.901 71.295 1.00 44.46 W O
ATOM 2519 O HOH W 106 42.068 72.425 65.081 1.00 23.22 W O
ATOM 2520 O HOH W 107 58.278 73.915 102.504 1.00 26.29 W O
ATOM 2521 O HOH W 108 51.701 69.048 84.689 1.00 35.12 W O
ATOM 2522 O HOH W 109 34.811 80.956 110.454 1.00 16.61 W O
ATOM 2523 O HOH W 110 34.633 67.764 103.863 1.00 29.92 W O
ATOM 2524 O HOH W 111 50.132 66.148 82.504 1.00 49.45 W O
ATOM 2525 O HOH W 112 48.693 77.370 107.610 1.00 25.11 W O
ATOM 2526 O HOH W 113 52.086 72.457 67.389 1.00 37.44 W O
ATOM 2527 O HOH W 114 46.605 58.747 102.657 1.00 40.55 W O
ATOM 2528 O HOH W 116 41.337 63.362 86.723 1.00 37.92 W O ATOM 2529 O HOH W 117 31.850 60.890 97.912 32.53 W O
ATOM 2530 O HOH W 118 36.922 55.510 72.517 49.69 W O
ATOM 2531 O HOH W 119 43.091 88.681 89.865 35.58 W O
ATOM 2532 O HOH W 120 48.122 87.086 79.406 28.76 W O
ATOM 2533 O HOH W 121 53.508 88.696 87.918 23.38 W O
ATOM 2534 O HOH W 122 42.415 83.005 108.577 19.17 W O
ATOM 2535 O HOH W 123 29.688 69.230 87.633 1.00 18.07 W O
ATOM 2536 O HOH W 124 52.362 69.896 68.623 .00 29.60 W O
ATOM 2537 O HOH W 125 54.218 74.039 85.181 .00 39.54 W O
ATOM 2538 O HOH W 126 26.736 54.739 65.752 .00 42.21 W O
ATOM 2539 O HOH W 127 53.152 79.371 106.391 .00 26.35 W O
ATOM 2540 O HOH W 128 28.481 47.097 77.145 .00 36.02 W O
ATOM 2541 O HOH W 129 38.253 91.447 91.781 .00 27.41 W O
ATOM 2542 O HOH W 130 41.969 61.601 100.180 1.00 43.79 W O
ATOM 2543 O HOH W 131 25.351 83.092 89.363 1.00 28.41 W O
ATOM 2544 O HOH W 132 60.671 78.458 80.028 1.00 42.44 W O
ATOM 2545 O HOH W 133 47.882 66.833 68.475 1.00 34.41 W O
ATOM 2546 O HOH W 134 46.488 77.809 108.531 1.00 25.40 W O
ATOM 2547 O HOH W 135 52.019 59.387 109.955 1.00 44.83 W O
ATOM 2548 O HOH W 136 56.137 74.402 103.152 1.00 29.65 W O
ATOM 2549 O HOH W 137 20.029 56.378 64.966 1.00 43.93 W O
ATOM 2550 O HOH W 138 49.493 57.993 80.785 1.00 41.38 W O
ATOM 2551 O HOH W 139 45.478 90.843 96.792 .00 25.71 W O
ATOM 2552 O HOH W 140 47.366 92.292 89.822 .00 35.04 W O
ATOM 2553 O HOH W 141 50.755 90.063 96.302 .00 22.65 W O
ATOM 2554 O HOH W 142 50.478 90.658 89.263 .00 24.91 W O
ATOM 2555 O HOH W 143 45.325 75.443 74.478 .00 78.67 W O
ATOM 2556 O HOH W 144 39.041 56.401 92.339 .00 43.70 W O
ATOM 2557 O HOH W 145 64.991 72.061 102.247 .00 36.33 W O
ATOM 2558 O HOH W 146 56.230 71.387 106.018 .00 34.40 W O
ATOM 2559 O HOH W 147 50.442 63.441 108.432 .00 30.03 W O
ATOM 2560 O HOH W 148 29.156 85.998 83.821 1.00 32.23 W O
ATOM 2561 O HOH W 149 32.173 73.991 102.505 1.00 50.99 W O
ATOM 2562 O HOH W 150 52.850 74.333 113.151 1.00 32.58 W O
ATOM 2563 O HOH W 151 36.384 71.136 106.917 1.00 46.35 W O
ATOM 2564 O HOH W 152 36.344 84.225 103.147 1.00 40.76 W O
ATOM 2565 O HOH W 153 41.150 89.234 103.709 1.00 25.71 W O
ATOM 2566 O HOH W 154 49.968 65.681 111.280 1.00 42.19 W O
END
Table 4. Atomic coordinates of Akt3 complexed to N-[(lS)-2-amino-l-(2,4- dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl)thiophene-2- carboxamide.
REMARK starting r= 0.2661 free _r= 0.3284
REMARK final r= 0.2408 free r= 0.2910
REMARK sg= P2 (1); » (1)2(1) a= 48 .693 b= 73 .027 C= 95.815 alpha= 90 beta= 90 gamma
CRYSTl 48. ,693 73.027 95. 815 90.00 90.00 90.00 P212121 1
SCALEl 0.020537 0 .000000 0.000000 0.00000
SCALE2 0.000000 0 .013694 0.000000 0.00000
ΞCALE3 0.000000 0 .000000 0.010437 0.00000
ATOM 1 CB LYS A 143 -1.941 22.119 26.725 1.00 39.33 AKT3 C
ATOM 2 CG LYS A 143 -2.643 23.046 27.715 1.00 39.40 AKT3 C
ATOM 3 CD LYS A 143 -4.165 23.039 27.576 1.00 39.85 AKT3 C
ATOM 4 CE LYS A 143 -4.624 23.642 26.255 1.00 40.53 AKT3 C
ATOM 5 NZ LYS A 143 -4.227 25.077 26.083 1.00 41.06 AKT3 N
ATOM 6 C LYS A 143 -1.285 19.749 26.273 1.00 39.77 AKT3 C
ATOM 7 O LYS A 143 -0.622 19.063 27.059 1.00 39.51 AKT3 O
ATOM 8 N LYS A 143 -2.703 20.270 28.192 1.00 40.08 AKT3 N
ATOM 9 CA LYS A 143 -2.397 20.657 26.786 1.00 39.69 AKT3 C
ATOM 10 N THR A 144 -1.077 19.746 24.959 1.00 40.65 AKT3 N
ATOM 11 CA THR A 144 -0.036 18.904 24.355 1.00 40.73 AKT3 C
ATOM 12 CB THR A 144 -0.660 17.842 23.441 1.00 40.50 AKT3 C
ATOM 13 OGl THR A 144 0.313 16.828 23.163 1.00 41.67 AKT3 O
ATOM 14 CG2 THR A 144 -1.130 18.479 22.130 1.00 39.90 AKT3 C
ATOM 15 C THR A 144 0.923 19.762 23.532 1.00 40.43 AKT3 C
ATOM 16 O THR A 144 0.959 20.977 23.713 1.00 39.70 AKT3 O
ATOM 17 N MET A 145 1.702 19.149 22.637 1.00 40.98 AKT3 N
ATOM 18 CA MET A 145 2.630 19.936 21.821 1.00 41.44 AKT3 C
ATOM 19 CB MET A 145 3.576 19.046 21.014 1.00 42.98 AKT3 C
ATOM 20 CG MET A 145 4.630 19.835 20.243 1.00 44.80 AKT3 C
ATOM 21 SD MET A 145 5.306 21.254 21.191 1.00 50.07 AKT3 S
ATOM 22 CE MET A 145 4.890 22.708 20.079 1.00 45.24 AKT3 C
ATOM 23 C MET A 145 1.849 20.860 20.897 1.00 41.00 AKT3 C
ATOM 24 O MET A 145 2.324 21.945 20.550 1.00 41.72 AKT3 O
ATOM 25 N ASN A 146 0.654 20.433 20.497 1.00 40.40 AKT3 N
ATOM 25 CA ASN A 146 -0.201 21.278 19.675 1.00 40.56 AKT3 C
ATOM 27 CB ASN A 146 -1.328 20.468 19.065 1.0O 40.20 AKT3 C
ATOM 28 CG ASN A 146 -0.813 19.341 18.223 1.00 41.05 AKT3 C
ATOM 29 ODl ASN A 146 0.194 18.714 18.570 1.00 38.81 AKT3 O
ATOM 30 ND2 ASN A 146 -1.495 19.065 17.111 1.00 40.37 AKT3 N
ATOM 31 C ASN A 146 -0.772 22.285 20.661 1.00 41.56 AKT3 C
ATOM 32 O ASN A 146 -0.316 22.358 21.805 1.00 42.35 AKT3 O
ATOM 33 N ASP A 147 -1.787 23.040 20.257 1.00 41.41 AKT3 N
ATOM 34 CA ASP A 147 -2.328 24.053 21.159 1.00 39.98 AKT3 C
ATOM 35 CB ASP A 147 -2.443 23.519 22.606 1.00 39.77 AKT3 C
ATOM 36 CG ASP A 147 -3.231 22.197 22.713 1.00 39.28 AKT3 C
ATOM 37 ODl ASP A 147 -4.446 22.194 22.434 1.00 37.24 AKT3 O
ATOM 38 OD2 ASP A 147 -2.633 21.159 23.096 1.00 38.95 AKT3 O
ATOM 39 C ASP A 147 -1.238 25.130 21.105 1.00 39.02 AKT3 C
ATOM 40 O ASP A 147 -1.442 26.285 21.500 1.00 39.80 AKT3 O
ATOM 41 N PHE A 148 -0.073 24.732 20.598 1.00 37.19 AKT3 N
ATOM 42 CA PHE A 148 1.069 25.631 20.490 1.00 35.84 AKT3 C
ATOM 43 CB PHE A 148 2.185 25.195 21.445 1.00 34.29 AKT3 C
ATOM 44 CG PHE A 148 1.773 25.171 22.881 1.00 32.08 AKT3 C
ATOM 45 CDl PHE A 148 1.422 26.341 23.533 1.00 31.43 AKT3 C
ATOM 46 CD2 PHE A 148 1.704 23.976 23.572 1.00 30.72 AKT3 C
ATOM 47 CEl PHE A 148 1.006 26.316 24.852 1.00 31.41 AKT3 C
ATOM 48 CE2 PHE A 148 1.291 23.948 24.882 1.00 30.41 AKT3 C
ATOM 49 CZ PHE A 148 0.940 25.121 25.525 1.00 30.12 AKT3 C
ATOM 50 C PHE A 148 1.661 25.734 19.097 1.00 35.03 AKT3 C
ATOM 51 O PHE A 148 1.752 24.747 18.369 1.00 36.01 AKT3 O
ATOM 52 N ASP A 149 2.062 26.952 18.752 1.00 33.62 AKT3 N
ATOM 53 CA ASP A 149 2.706 27.243 17.488 1.00 31.98 AKT3 C
ATOM 54 CB ASP A 149 2.199 28.562 16.877 1.00 32.86 AKT3 C
ATOM 55 CG ASP A 149 0.821 28.442 16.254 1.00 34.94 AKT3 C
ATOM 56 ODl ASP A 149 0.507 27.376 15.675 1.00 36.06 AKT3 O
ATOM 57 OD2 ASP A 149 0.056 29.431 16.326 1.00 36.43 AKT3 O 69
ATOM 58 C ASP A 149 4.191 27.409 17.797 1.00 30.91 AKT3 C
ATOM 59 O ASP A 149 4.582 28.337 18.505 1.00 29.47 AKT3 O
ATOM 60 N TYR A 150 5.014 26.499 17.295 1.00 29.74 AKT3 N
ATOM 61 CA TYR A 150 6.458 26.591 17.482 1.00 27.59 AKT3 C
ATOM 62 CB TYR A 150 7.101 25.322 16.918 1.00 29.72 AKT3 C
ATOM 63 CG TYR A 150 8.601 25.361 16.723 1.00 32.92 AKT3 C
ATOM 64 CDl TYR A 150 9.314 26.548 16.847 1.00 34.12 AKT3 C
ATOM 65 CEl TYR A 150 10.678 26.591 16.624 1.00 36.00 AKT3 C
ATOM 66 CD2 TYR A 150 9.300 24.211 16.371 1.00 34.00 AKT3 C
ATOM 67 CE2 TYR A 150 10.666 24.243 16.145 1.00 36.40 AKT3 C
ATOM 68 CZ TYR A 150 11.351 25.439 16.272 1.00 36.66 AKT3 C
ATOM 69 OH TYR A 150 12.709 25.488 16.041 1.00 37.92 AKT3 O
ATOM 70 C TYR A 150 6.862 27.834 16.676 1.00 25.58 AKT3 C
ATOM 71 O TYR A 150 6.779 27.832 15.451 1.00 25.73 AKT3 O
ATOM 72 N LEU A 151 7.275 28.899 17.358 1.00 23.34 AKT3 N
ATOM 73 CA LEU A 151 7.649 30.148 16.686 1.00 22.54 AKT3 C
ATOM 74 CB LEU A 151 7.063 31.353 17.434 1.00 21.93 AKT3 C
ATOM 75 CG LEU A 151 5.686 31.806 16.935 1.00 23.19 AKT3 C
ATOM 76 CDl LEU A 151 4.764 30.616 16.861 1.00 23.73 AKT3 C
ATOM 77 CD2 LEU A 151 5.107 32.872 17.846 1.00 23.16 AKT3 C
ATOM 78 C LEU A 151 9.136 30.382 16.454 1.00 23.34 AKT3 C
ATOM 79 O LEU A 151 9.535 30.764 15.352 1.00 21.80 AKT3 O
ATOM 80 N LYS A 152 9.955 30.159 17.480 1.00 22.48 AKT3 N
ATOM 81 CA LYS A 152 11.383 30.370 17.335 1.00 22.02 AKT3 C
ATOM 82 CB LYS A 152 11.671 31.862 17.423 1.00 20.64 AKT3 C
ATOM 83 CG LYS A 152 12.975 32.284 16.796 1.00 20.84 AKT3 C
ATOM 84 CD LYS A 152 13.124 33.789 16.836 1.00 19.74 AKT3 C
ATOM 85 CE LYS A 152 14.219 34.245 15.891 1.00 19.72 AKT3 C
ATOM 86 NZ LYS A 152 15.451 33.462 16.107 1.00 18.20 AKT3 N
ATOM 87 C IJYS A 152 12.188 29.627 18.392 1.00 23.14 AKT3 C
ATOM 88 O LYS A 152 11.649 29.216 19.420 1.00 24.83 AKT3 O
ATOM 89 N LEU A 153 13.479 29.441 18.135 1.00 22.71 AKT3 N
ATOM 90 CA LEU A 153 14.349 28.775 19.097 1.00 22.69 AKT3 C
ATOM 91 CB LEU A 153 15.415 27.943 18.385 1.00 23.52 AKT3 C
ATOM 92 CG LEU A 153 16.447 27.248 19.283 1.00 25.58 AKT3 C
ATOM 93 CDl LEU A 153 15.771 26.576 20.480 1.00 26.40 AKT3 C
ATOM 94 CD2 LEU A 153 17.201 26.213 18.459 1.00 27.71 AKT3 C
ATOM 95 C LEU A 153 15.002 29.860 19.946 1.00 23.48 AKT3 C
ATOM 96 O LEU A 153 15.699 30.730 19.429 1.00 23.14 AKT3 O
ATOM 97 N LEU A 154 14.763 29.812 21.254 1.00 23.50 AKT3 N
ATOM 98 CA LEU A 154 15.296 30.814 22.169 1.00 22.64 AKT3 C
ATOM 99 CB LEU A 154 14.256 31.126 23.243 1.00 20.74 AKT3 C
ATOM 100 CG LEU A 154 12.941 31.682 22.694 1.00 19.78 AKT3 C
ATOM 101 CDl LEU A 154 11.972 31.919 23.832 1.00 15.52 AKT3 C
ATOM 102 CD2 LEU A 154 13.220 32.973 21.925 1.00 16.98 AKT3 C
ATOM 103 C LEU A 154 16.614 30.432 22.829 1.00 23.73 AKT3 C
ATOM 104 O LEU A 154 17.376 31.303 23.258 1.00 23.65 AKT3 O
ATOM 105 N GLY A 155 16.879 29.135 22.908 1.00 23.77 AKT3 N
ATOM 106 CA GLY A 155 18.108 28.677 23.518 1.00 26.00 AKT3 C
ATOM 107 C GLY A 155 18.212 27.170 23.523 1.00 28.24 AKT3 C
ATOM 108 O GLY A 155 17.197 26.469 23.478 1.00 26.96 AKT3 O
ATOM 109 N LYS A 156 19.440 26.667 23.582 1.00 31.06 AKT3 N
ATOM 110 CA LYS A 156 19.645 25.228 23.586 1.00 35.54 AKT3 C
ATOM 111 CB LYS A 156 19.704 24.714 22.140 1.00 37.20 AKT3 C
ATOM 112 CG LYS A 156 19.604 23.183 21.973 1.00 41.05 AKT3 C
ATOM 113 CD LYS A 156 20.981 22.515 21.801 1.00 42.73 AKT3 C
ATOM 114 CE LYS A 156 20.873 20.989 21.655 1.00 42.94 AKT3 C
ATOM 115 NZ LYS A 156 20.329 20.358 22.901 1.00 43.61 AKT3 N
ATOM 116 C LYS. A 156 20.885 24.771 24.363 1.00 37.35 AKT3 C
ATOM 117 O LYS A 156 22.033 24.980 23.933 1.00 37.48 AKT3 O
ATOM 118 N GLY A 157 20.630 24.160 25.523 1.00 39.36 AKT3 N
ATOM 119 CA GLY A 157 21.692 23.616 26.362 1.00 39.66 AKT3 C
ATOM 120 C GLY A 157 21.493 22.111 26.314 1.0O 39.71 AKT3 C
ATOM 121 O GLY A 157 20.638 21.650 25.560 1.00 39.96 AKT3 O
ATOM 122 N THR A 158 22.239 21.333 27.088 1.00 40.15 AKT3 N
ATOM 123 CA THR A 158 22.037 19.890 27.036 1.00 40.31 AKT3 C
ATOM 124 CB THR A 158 23.232 19.128 27.616 1.00 41.40 AKT3 C
ATOM 125 OGl THR A 158 23.137 19.109 29.046 1.00 43.05 AKT3 O
ATOM 126 CG2 THR A 158 24.545 19.802 27.193 1.00 40.97 AKT3 C
ATOM 127 C THR A 158 20.773 19.500 27.810 1.00 39.83 AKT3 C
ATOM 128 O THR A 158 20.009 18.620 27.382 1.00 39.13 • AKT3 O
ATOM 129 N PHE A 159 20.552 20.153 28.947 1.0O 39.48 AKT3 N
ATOM 130 CA PHE A 159 19.365 19.866 29.755 1.0O 40.12 AKT3 C ATOM 131 CB PHE A 159 19.141 20.956 30.830 1.00 42.38 AKT3 C
ATOM 132 CG PHE A 159 20.376 21.307 31.642 1.00 45.43 AKT3 C
ATOM 133 CDl PHE A 159 20.481 22.560 32.262 1.00 47.00 AKT3 C
ATOM 134 CD2 PHE A 159 21.422 20.402 31.796 1.00 46.26 AKT3 C
ATOM 135 CEl PHE A 159 21.613 22.907 33.021 1.00 47.22 AKT3 C
ATOM 136 CE2 PHE A 159 22.560 20.741 32.556 1.00 48.08 AKT3 C
ATOM 137 CZ PHE A 159 22.653 21.998 33.168 1.00 47.12 AKT3 C
ATOM 138 C PHE A 159 18.162 19.855 28.802 1.00 38.16 AKT3 C
ATOM 139 O PHE A 159 17.176 19.153 29.034 1.00 38.60 AKT3 O
ATOM 140 N GLY A 160 18.254 20.644 27.731 1.00 36.02 AKT3 N
ATOM 141 CA GLY A 160 17.170 20.725 26.763 1.00 33.37 AKT3 C
ATOM 142 C GLY A 160 17.126 22.036 25.987 1.00 31.92 AKT3 C
ATOM 143 O GLY A 160 18.161 22.658 25.728 1.00 32.34 AKT3 O
ATOM 144 N LYS A 161 15.931 22.476 25.607 1.00 29.98 AKT3 N
ATOM 145 CA LYS A 161 15.835 23.718 24.860 1.00 28.81 AKT3 C
ATOM 146 CB LYS A 161 15.886 23.436 23.357 1.00 28.88 AKT3 C
ATOM 147 CG LYS A 161 14.814 22.490 22.845 1.00 30.84 AKT3 C
ATOM 148 CD LYS A 161 14.900 22.357 21.328 1.00 33.81 AKT3 C
ATOM 149 CE IiYS A 161 13.825 21.422 20.774 1.00 36.53 AKT3 C
ATOM 150 NZ LYS A 161 13.752 21.466 19.279 1.00 37.50 AKT3 N
ATOM 151 C LYS A 161 14.615 24.569 25.180 1.00 27.35 AKT3 C
ATOM 152 O LYS A 161 13.585 24.065 25.616 1.00 25.67 AKT3 O
ATOM 153 N VAL A 162 14.761 25.875 24.971 1.00 26.62 AKT3 N
ATOM 154 CA VAL A 162 13.676 26.820 25.199 1.00 25.75 AKT3 C
ATOM 155 CB VAL A 162 14.134 28.049 25.989 1.00 25.12 AKT3 C
ATOM 156 CGl VAL A 162 12.949 28.631 26.731 1.00 25.84 AKT3 C
ATOM 157 CG2 VAL A 162 15.252 27.681 26.943 1.00 26.05 AKT3 C
ATOM 158 C VAL A 162 13.193 27.282 23.828 1.00 25.04 AKT3 C
ATOM 159 O VAL A 162 13.989 27.473 22.911 1.00 23.67 AKT3 O
ATOM 160 N ILE A 163 11.888 27.467 23.700 1.00 24.09 AKT3 N
ATOM 161 CA ILE A 163 11.302 27.867 22.437 1.00 23.83 AKT3 C
ATOM 162 CB ILE A 163 10.757 26.631 21.689 1.00 24.85 AKT3 C
ATOM 163 CG2 ILE A 163 9.906 27.054 20.513 1.00 24.93 AKT3 C
ATOM 164 CGl ILE A 163 ' 11.916 25.755 21.232 1.00 25.13 AKT3 C
ATOM 165 CDl ILE A 163 11.478 24.459 20.628 1.00 26.27 AKT3 C
ATOM 166 C ILE A 163 10.157 28.836 22.622 1.00 24.13 AKT3 C
ATOM 167 O ILE A 163 9.333 28.666 23.528 1,00 25.31 AKT3 O
ATOM 168 N LEU A 164 10.097 29.850 21.764 1.00 21.81 AKT3 N
ATOM 169 CA LEU A 164 9.008 30.806 21.834 1.00 20.89 AKT3 C
ATOM 170 CB LEU A 164 9.374 32.099 21.110 1.00 20.23 AKT3 C
ATOM 171 CG LEU A 164 8.171 33.025 20.928 1.00 18.30 AKT3 C
ATOM 172 CDl LEU A 164 7.499 33.247 22.279 1.00 20.26 AKT3 C
ATOM 173 CD2 LEU A 164 8.611 34.334 20.313 1.00 17.21 AKT3 C
ATOM 174 C LEU A 164 7.788 30.169 21.167 1.00 22.07 AKT3 C
ATOM 175 O LEU A 164 7.869 29.701 20.034 1.00 20.66 AKT3 O
ATOM 176 N VAL A 165 6.664 30.136 21.875 1.00 22.51 AKT3 N
ATOM 177 CA VAL A 165 5.456 29.550 21.324 1.00 23.47 AKT3 C
ATOM 178 CB VAL A 165 5.171 28.151 21.921 1.00 23.21 AKT3 C
ATOM 179 CGl VAL A 165 • 6.364 27.238 21.707 1'.00 19.94 AKT3 C
ATOM 180 CG2 VAL A 165 4.830 28.272 23.397 1.00 23.13 AKT3 C
ATOM 181 C VAL A 165 4.232 30.425 21.550 1.00 25.78 AKT3 C
ATOM 182 O VAL A 165 4.272 31.407 22.279 1.00 25.41 AKT3 O
ATOM 183 N ARG A 166 3.139 30.044 20.903 1.00 28.30 AKT3 N
ATOM 184 CA ARG A 166 1.883 30.765 20.985 1.00 30.78 AKT3 C
ATOM 185 CB ARG A 166 1.614 31.498 19.669 1.00 30.33 AKT3 C
ATOM 186 CG ARG A 166 0.158 31.444 19.229 1.00 32.15 AKT3 C
ATOM 187 CD ARG A 166 -0.010 31.819 17.759 1.00 32.97 AKT3 C
ATOM 188 NE ARG A 166 0.312 33.218 17.488 1.00 33.89 AKT3 N
ATOM 189 CZ ARG A 166 0.988 33.630 16.413 1.00 34.53 AKT3 C
ATOM 190 NHl ARG A 166 1.418 32.748 15.509 1.00 32.64 AKT3 N
ATOM 191 NH2 ARG A 166 1.238 34.925 16.242 1.00 33.19 AKT3 N
ATOM 192 C ARG A 166 0.792 29.735 21.209 1.00 32.79 AKT3 C
ATOM 193 O ARG A 166 0.669 28.780 20.438 1.00 34.05 AKT3 O
ATOM 194 N GLU A 167 0.008 29.904 22.266 1.00 34.34 AKT3 N
ATOM 195 CA GLU A 167 -1.074 28.962 22.506 1.00 35.82 AKT3 C
ATOM 196 CB GLU A 167 -1.758 29.260 23.843 1.00 37.33 AKT3 C
ATOM 197 CG GLU A 167 -2.810 28.229 24.242 1.00 39.69 AKT3 C
ATOM 198 CD GLU A 167 -3.352 28.467 25.637 1.00 41.19 AKT3 C
ATOM 199 OEl GLU A 167 -3.709 27.470 26.310 1.00 43.49 AKT3 O
ATOM 200 OE2 GLU A 167 -3.431 29.644 26.060 1.00 40.34 AKT3 O
ATOM 201 C GLU A 167 -2.052 29.187 21.360 1.00 35.37 AKT3 C
ATOM 202 O GLU A 167 -2.526 30.305 21.169 1.00 35.08 AKT3 O
ATOM 203 N LYS A 168 -2.334 28.151 20.576 1.00 35.11 AKT3 N ATOM 204 CA LYS A 168 -3.268 28.315 19.465 .00 35.20 AKT3 C
ATOM 205 CB LYS A 168 -3.484 26.996 18.706 .00 34.83 AKT3 C
ATOM 206 CG LYS A 168 -2.275 26.397 18.002 ,00 35.23 AKT3 C
ATOM 207 CD LYS A 168 -2.749 25.382 16.955 .00 34.45 AKT3 C
ATOM 208 CE LYS A 168 -1.626 24.497 16.430 ,00 35.78 AKT3 C
ATOM 209 NZ LYS A 168 -1.319 23.375 17.371 .00 36.65 AKT3 N
ATOM 210 C LYS A 168 -4.607 28.749 20.062 .00 35.28 AKT3 C
ATOM 211 O LYS A 168 -5.159 29.796 19.710 .00 33.94 AKT3 O
ATOM 212 N ALA A 169 -5.104 27.922 20.980 .00 35.99 AKT3 K
ATOM 213 CA ALA A 169 -6.385 28.138 21.652 1.00 36.14 AKT3 C
ATOM 214 CB ALA A 169 -6.478 27.225 22.876 00 37.86 AKT3 C
ATOM 215 C ALA A 169 -6.664 29.578 22.059 00 35.65 AKT3 C
ATOM 215 O ALA A 169 -7.781 30.058 21.897 00 36.49 AKT3 O
ATOM 217 N SER A 170 -5.648 30.260 22.583 .00 35.49 AKT3 N
ATOM 218 CA SER A 170 -5.777 31.648 23.029 ,00 33.98 AKT3 C
ATOM 219 CB SER A 170 -5.422 31.754 24.513 ,00 34.39 AKT3 C
ATOM 220 OG SER A 170 -4..059 31.410 24.737 ,00 32.42 AKT3 O
ATOM 221 C SER A 170 .874 32.594 22.256 00 33.94 AKT3 C
ATOM 222 O SER A 170 .053 33.810 22.309 ,00 33.93 AKT3 O
ATOM 223 N GLY A 171 -3..887 32.046 21.556 ,00 33.21 AKT3 N
ATOM 224 CA GLY A 171 -2.980 32.892 20.802 ,00 33.20 AKT3 C
ATOM 225 C GLY A 171 -2..069 33.737 21.682 ,00 33.81 AKT3 C
ATOM 226 O GLY A 171 -1..560 34.776 21.251 ,00 34.70 AKT3 O
ATOM 227 N LYS A 172 -1..867 33.307 22.925 .00 33.78 AKT3 N
ATOM 228 CA LYS A 172 -0.994 34.029 23.846 .00 32.62 AKT3 C
ATOM 229 CB LYS A 172 -1.422 33.799 25.294 ,00 33.81 AKT3 C
ATOM 230 CG LYS A 172 -2.786 34.388 25.675 .00 35.95 AKT3 C
ATOM 231 CD LYS A 172 -2.803 35.926 25.617 ,00 37.75 AKT3 C
ATOM 232 CE LYS A 172 -3.135 36.459 24.215 .00 39.88 AKT3 C
ATOM 233 N2 LYS A 172 -2.097 36.163 23.162 .00 39.14 AKT3 N
ATOM 234 C LYS A 172 0.424 33.521 23.643 .00 32.70 AKT3 C
ATOM 235 O LYS A 172 0.629 32.377 23.224 .00 31.98 AKT3 O
ATOM 236 N TYR A 173 1.403 34.368 23.933 .00 31.93 AKT3 N
ATOM 237 CA TYR A 173 2.792 33.979 23.756 .00 31.72 AKT3 C
ATOM 238 CB TYR A 173 3.609 35.150 23.203 .00 32.87 AKT3 C
ATOM 239 CG TYR A 173 3.133 35.625 21.840 .00 33.69 AKT3 C
ATOM 240 CDl TYR A 173 2.217 36.666 21.725 .00 33.66 AKT3 C
ATOM 241 CEl TYR A 173 1.756 37.071 20.488 .00 34.98 AKT3 C
ATOM 242 CD2 TYR A 173 3.571 35.003 20.673 .00 33.10 AKT3 C
ATOM 243 CE2 TYR A 173 3.113 35.401 19.435 .00 33.46 AKT3 C
ATOM 244 CZ TYR A 173 2.208 36.432 19.346 .00 34.74 AKT3 C
ATOM 245 OH TYR A 173 1.738 36.824 18.114 .00 36.26 AKT3 O
ATOM 246 C TYR A 173 3.431 33.477 25.033 .00 31.33 AKT3 C
ATOM 247 O TYR A 173 3.229 34.052 26.102 .00 32.32 AKT3 O
ATOM 248 N TYR A 174 4.202 32.399 24.914 .00 29.40 AKT3 N
ATOM 249 CA TYR A 174 4.891 31.823 26.058 .00 29.14 AKT3 C
ATOM 250 CB TYR A 174 4.117 30.644 26.652 .00 28.74 AKT3 C
ATOM 251 CG TYR A 174 2.811 31.031 27.278 .00 29.27 AKT3 C
ATOM 252 CDl TYR A 174 2.775 31.755 28.464 .00 28.69 AKT3 C
ATOM 253 CEl TYR A 174 1.573 32.174 29.000 .00 29.26 AKT3 C
ATOM 254 CD2 TYR A 174 1.608 30.728 26.649 .00 28.33 AKT3 C
ATOM 255 CE2 TYR A 174 0.408 31.139 27.174 .00 29.19 AKT3 C
ATOM 256 CZ TYR A 174 0.390 31.863 28.346 .00 28.68 AKT3 C
ATOM 257 OH TYR A 174 -0.813 32.286 28.849 .00 29.59 AKT3 O
ATOM 258 C TYR A 174 6.265 31.326 25.680 .00 29.01 AKT3 C
ATOM 259 O TYR A 174 6.676 31.371 24.522 .00 29.45 AKT3 O
ATOM 260 N ALA A 175 6.961 30.845 26.698 .00 28.68 AKT3 N
ATOM 261 CA ALA A 175 8.284 30.296 26.554 .00 28.37 AKT3 C
ATOM 262 CB ALA A 175 9.279 31.128 27.359 .00 28.82 AKT3 C
ATOM 263 C ALA A 1.75 8.201 28.870 27.099 .00 27.89 AKT3 C
ATOM 264 O ALA A 175 8.004 28.662 28.301 .00 26.35 AKT3 O
ATOM 265 N MET A 176 8.325 27.893 26.204 .00 28.00 AKT3 N
ATOM 266 CA MET A 176 8.266 26.491 26.592 .00 27.60 AKT3 C
ATOM 267 CB MET A 176 7.470 25.676 25.577 .00 26.07 AKT3 C
ATOM 268 CG MET A 176 7.420 24.189 25.913 .00 27.21 AKT3 C
ATOM 269 SD MET A 176 6.542 23.220 24.664 .00 26.73 AKT3 S
ATOM 270 CE MET A 176 4.942 22.908 25.453 .00 29.57 AKT3 C
ATOM 271 C MET A 176 9.652 25.888 26.730 .00 27.84 AKT3 C
ATOM 272 O MET A 176 10.522 26.064 25.865 ,00 28.56 AKT3 O
ATOM 273 N LYS A 177 9.856 25.176 27.829 ,00 27.65 AKT3 N
ATOM 274 CA LYS A 177 11.131 24.544 28.072 ,00 26.91 AKT3 C
ATOM 275 CB LYS A 177 11.631 24.856 29.480 .00 25.92 AKT3 C
ATOM 276 CG LYS A 177 12.040 26.295 29.705 1.00 22.96 AKT3 C ATOM 277 CD LYS A 177 13.124 26.394 30.772 23.58 AKT3 C
ATOM 278 CE LYS A 177 13.659 27.815 30.878 24.04 AKT3 C
ATOM 279 NZ LYS A 177 14.716 27.966 31.924 22.37 AKT3 N
ATOM 280 C LYS A 177 10.964 23.053 27.908 28.52 AKT3 C
ATOM 281 O LYS A 177 10.087 22.450 28.514 28.54 AKT3 O
ATOM 282 N ILE A 178 11.793 22.470 27.053 30.35 AKT3 N
ATOM 283 CA ILE A 178 11.765 21.044 26.819 30.70 AKT3 C
ATOM 284 CB ILE A 178 11.773 20.706 25.321 30.36 AKT3 C
ATOM 285 CG2 ILE A 178 12.025 19.214 25.126 29.72 AKT3 C
ATOM 286 CGl ILE A 178 10.439 21.104 24.702 29.93 AKT3 C
ATOM 287 CDl ILE A 178 10.059 22.533 24.962 29.10 AKT3 C
ATOM 288 C ILE A 178 13.025 20.505 27.454 31.83 AKT3 C
ATOM 289 0 ILE A 178 14.112 21.032 27.238 31.39 AKT3 O
ATOM 290 N LEU A 179 12.875 19.449 28.239 33.00 AKT3 N
ATOM 291 CA LEU A 179 14.004 18.859 28.923 33.18 AKT3 C
ATOM 292 CB LEU A 179 13.943 19.220 30.407 33.64 AKT3 C
ATOM 293 CG LEU A 179 13.596 20.684 30.687 32.91 AKT3 C
ATOM 294 CDl LEU A 179 12.7S2 20.791 31.954 31.28 AKT3 C
ATOM 295 CD2 LEU A 179 14.883 21.494 30.773 31.48 AKT3 C
ATOM 296 C LEU A 179 13.902 17.367 28.772 33.89 AKT3 C
ATOM 297 O LEU A 179 12.866 16.781 29.062 34.47 AKT3 O
ATOM 298 N LYS A 180 14.973 16.743 28.306 35.29 AKT3 N
ATOM 299 CA LYS A 180 14.955 15.298 28.161 34.96 AKT3 C
ATOM 300 CB LYS A 180 16.133 14.825 27.314 36.27 AKT3 C
ATOM 301 CG LYS A 180 17.360 15.711 27.389 37.79 AKT3 C
ATOM 302 CD LYS A 180 17.311 16.751 26.286 39.47 AKT3 C
ATOM 303 CE LYS A 180 17.204 16.077 24.921 38.93 AKT3 C
ATOM 304 NZ LYS A 180 17.067 17.071 23.823 40.30 AKT3 N
ATOM 305 C LYS A 180 15.034 14.571 29.542 34.15 AKT3 C
ATOM 306 O LYS A 180 15.904 15.020 30.342 32.96 AKT3 O
ATOM 307 N LYS A 181 14.121 13.744 29.818 34.71 AKT3 N
ATOM 308 CA LYS A 181 14.097 13.060 31.108 34.17 AKT3 C
ATOM 309 CB LYS A 181 12.962 12.034 31.130 31.58 AKT3 C
ATOM 310 CG LYS A 181 11.581 12.681 31.115 32.23 AKT3 C
ATOM 311 CD LYS A 181 10.446 11.703 30.809 30.77 AKT3 C
ATOM 312 CE LYS A 181 9.083 12.394 30.965 31.38 AKT3 C
ATOM 313 NZ LYS A 181 7.966 11.710 30.245 1.00 29.50 AKT3 N
ATOM 314 C LYS A 181 15.439 12.394 31.429 .00 35.03 AKT3 C
ATOM 315 O LYS A 181 15.962 12.557 32.536 .00 34.92 AKT3 O
ATOM 316 N GLU A 182 16.015 11.671 30.465 ,00 36.08 AKT3 N
ATOM 317 CA GLU A 182 17.292 10.992 30.705 .00 37.76 AKT3 C
ATOM 318 CB GLU A 182 17.854 10.337 29.431 .00 38.75 AKT3 C
ATOM 319 CG GLU A 182 16.875 10.187j 28.285 .00 41.72 AKT3 C C
ATOM 320 CD GLU A 182 16.477 11.528 27.698 .00 43.52 AKT3 C C
ATOM 321 OEl GLU A 182 15.456 12.103 28.155 .00 43.78 AKT3 O O
ATOM 322 OE2 GLU A 182 17.201 12.007 26.794 .00 42.32 AKT3 O
ATOM 323 C GLU A 182 18.336 11.958 31.242 .00 37.15 AKT3 C
ATOM 324 O GLU A 182 18.991 11.683 32.246 .00 38.10 AKT3 O
ATOM 325 N VAL A 183 18.495 13.092 30.579 .00 36.50 AKT3 N
ATOM 326 CA VAL A 183 19.485 14.050 31.035 .00 35.84 AKT3 C C
ATOM 327 CB VAL A 183 19.503 15.288 30.126 .00 35.57 AKT3 C C
ATOM 328 CGl VAL A 183 18.246 16.103 30.343 .00 36.82 AKT3 C C
ATOM 329 CG2 VAL A 183 20.748 16.103 30.383 .00 33.65 AKT3 C C
ATOM 330 C VAL A 183 19.195 14.455 32.479 .00 34.71 AKT3 C C
ATOM 331 O VAL A 183 20.111 14.568 33.287 .00 35.50 AKT3 O
ATOM 332 N ILE A 184 17.923 14.661 32.810 .00 34.47 AKT3 N
ATOM 333 CA ILE A 184 17.547 15.051 34.170 .00 32.80 AKT3 C
ATOM 334 CB ILE A 184 16.018 15.271 34.313 .00 33.00 AKT3 C
ATOM 335 CG2 ILE A 184 15.685 15.653 35.752 .00 34.21 AKT3 C
ATOM 336 CGl ILE A 184 15.541 16.372 33.369 ,00 32.09 AKT3 C
ATOM 337 CDl ILE A 184 16.041 17.743 33.725 .00 31.31 AKT3 C
ATOM 338 C ILE A 184 17.950 13.928 35.115 .00 32.25 AKT3 C
ATOM 339 O ILE A 184 18.623 14.150 36.113 .00 32.85 AKT3 O
ATOM 340 N ILE A 185 17.523 12.715 34.794 .00 31.57 AKT3 N
ATOM 341 CA ILE A 185 17.858 11.553 35.604 .00 31.53 AKT3 C
ATOM 342 CB ILE A 185 17.234 10.283 35.023 .00 28.98 AKT3 C
ATOM 343 CG2 ILE A 185 17.912 9.072 35.627 .00 28.28 AKT3 C
ATOM 344 CGl ILE A 185 15.720 10.293 35.270 .00 28.02 AKT3 C
ATOM 345 CDl ILE A 185 14.950 9.260 34.475 .00 25.54 AKT3 C
ATOM 346 C ILE A 185 19.372 11.352 35.643 ,00 32.57 AKT3 C
ATOM 347 O ILE A 185 19.974 11.243 36.716 ,00 32.09 AKT3 O
ATOM 348 N ALA A 186 19.969 11.310 34.456 .00 33.57 AKT3 N
ATOM 349 CA ALA A 186 21.400 11.111 34.293 1.00 34.50 AKT3 C ATOM 350 CB ALA A 186 21.761 11.202 32.826 32 .74 AKT3 C
ATOM 351 C ALA A 186 22.273 12.068 35.100 34 .54 AKT3 C
ATOM 352 O ALA A 186 23.480 12.103 34.916 33 .73 AKT3 O
ATOM 353 N LYS A 187 21.675 12.850 35.988 37 .37 AKT3 N
ATOM 354 CA LYS A 187 22.471 13.770 36.798 39 .45 AKT3 C
ATOM 355 CB LYS A 187 22.874 14.995 35.977 39.09 AKT3 C
ATOM 35S CG LYS A 187 21.841 16.111 35.965 38 .38 AKT3 C
ATOM 357 CD LYS A 187 22.557 17.455 35.884 39 .21 AKT3 C
ATOM 358 CE LYS A 187 23.655 17.543 36.948 1. 00 38.29 AKT3 C
ATOM 359 NZ LYS A 187 24.299 18.897 37.050 37 .09 AKT3 N
ATOM 360 C LYS A 187 21.740 14.242 38.053 39 . 86 AKT3 C
ATOM 361 O LYS A 187 22.123 15.250 38.651 39.58 AKT3 O
ATOM 362 N ASP A 188 20.704 13.505 38.450 40 .49 AKT3 N
ATOM 363 CA ASP A 188 19.905 13.869 39.621 40.47 AKT3 C
ATOM 364 CB ASP A 188 20.798 14.439 40.715 41.24 AKT3 C
ATOM 365 CG ASP A 188 21.724 13.396 41.291 43 .36 AKT3 C
ATOM 366 ODl ASP A 188 21.251 12.585 42.131 42.00 AKT3 O
ATOM 367 OD2 ASP A 188 22.911 13.381 40.882 42 .55 AKT3 O
ATOM 368 C ASP A 188 18.873 14.904 39.211 39 .24 AKT3 C
ATOM 369 O ASP A 188 17.962 14.615 38.431 38 .85 AKT3 O
ATOM 370 N GLU A 189 19.014 16.111 39.736 37 .69 AKT3 N
ATOM 371. CA GLU A 189 18.083 17.183 39.390 37.22 AKT3 C
ATOM 372 CB GLU A 189 18.519 17.837 38.062 38 .06 AKT3 C
ATOM 373 CG GLU A 189 19.045 19.259 38.196 39 .38 AKT3 C
ATOM 374 CD GLU A 189 20.098 19.418 39.306 41.01 AKT3 C
ATOM 375 OEl GLU A 189 21.116 18.674 39.298 41. 84 AKT3 O
ATOM 376 OE2 GLU A 189 19.909 20.297 40.180 38 .02 AKT3 O
ATOM 377 C GLU A 189 16.618 16.734 39.286 34 . 02 AKT3 C
ATOM 378 O GLU A 189 15.753 17.542 38.963 33 .16 AKT3 O
ATOM 379 N VAL A 190 16.340 15.460 39.553 31.34 AKT3 N
ATOM 380 CA VAL A 190 14.970 14.971 39.479 30 .32 AKT3 C
ATOM 381 CB VAL A 190 14.890 13.423 39.589 29.52 AKT3 C
ATOM 382 CGl VAL A 190 13.435 12.994 39.714 28.02 AKT3 C
ATOM 383 CG2 VAL A 190 15.495 12.774 38.354 28 .70 AKT3 C
ATOM 384 C VAL A 190 14.174 15.594 40.620 29 .95 AKT3 C
ATOM 385 O VAL A 190 13.241 16.360 40.389 29 . 84 AKT3 O
ATOM 386 N ALA A 191 14.545 15.261 41.853 30 .35 AKT3 N
ATOM 387 CA ALA A 191 13.880 15.813 43.023 29.97 AKT3 C
ATOM 388 CB ALA A 191 14.651 15.446 44.271 29 .33 AKT3 C
ATOM 389 C ALA A 191 13.874 17.328 42.849 31.25 AKT3 C
ATOM 390 O ALA A 191 12.843 17.992 42.986 31.24 AKT3 O
ATOM 391 N HIS A 192 15.049 17.863 42.540 30 .42 AKT3 N
ATOM 392 CA HIS A 192 15.204 19.290 42.347 31.41 AKT3 C
ATOM 393 CB HIS A 192 16.622 19.590 41.859 31 .01 AKT3 C
ATOM 394 CG HIS A 192 16.926 21.050 41.775 32 .22 AKT3 C
ATOM 395 CD2 HIS A 192 16.323 22.118 42.349 33.46 AKT3 C
ATOM 396 NDl HIS A 192 17.972 21.552 41.032 33 .48 AKT3 N
ATOM 397 CEl HIS A 192 18.002 22.868 41.152 33 .72 AKT3 C
ATOM 398 NE2 HIS A 192 17.012 23.237 41.946 34 .70 AKT3 N
ATOM 399 C HIS A 192 14.177 19.800 41.329 30 .42 AKT3 C
ATOM 400 O HIS A 192 13.379 20.700 41.613 28 .83 AKT3 O
ATOM 401 N THR A 193 14.213 19.206 40.145 30 .57 AKT3 N
ATOM 402 CA THR A 193 13.315 19.565 39.062 32 .76 AKT3 C
ATOM 403 CB THR A 193 13.390 18.536 37.928 33 .12 AKT3 C
ATOM 404 OGl THR A 193 12.949 19.138 36.711 34 .89 AKT3 O
ATOM 405 CG2 THR A 193 12.476 17.344 38.222 34 .08 AKT3 C
ATOM 406 C THR A 193 11.859 19.640 39.507 34 .42 AKT3 C
ATOM 407 O THR A 193 11.161 20.621 39.236 35 .51 AKT3 O
ATOM 408 N LEU A 194 11.402 18.597 40.189 35 .75 AKT3 N
ATOM 409 CA LEU A 194 10.017 18.525 40.636 36 .44 AKT3 C
ATOM 410 CB LEU A 194 9.709 17.103 41.120 37.97 AKT3 C
ATOM 411 CG LEU A 194 8.273 16.781 41.550 38.87 AKT3 C
ATOM 412 CDl LEU A 194 7.274 17.364 40.554 39 .06 AKT3 C
ATOM 413 CD2 LEU A 194 8.122 15.261 41.678 37 .73 AKT3 C
ATOM 414 C LEU A 194 9.679 19.545 41.712 36.08 AKT3 C
ATOM 415 O LEU A 194 8.687 20.259 41.607 35 .22 AKT3 O
ATOM 416 N THR A 195 10.494 19.608 42.755 36.77 AKT3 N
ATOM 417 CA THR A 195 10.246 20.575 43.818 37.19 AKT3 C
ATOM 418 CB THR A 195 11.379 20.550 44.855 38 .20 AKT3 C
ATOM 419 OGl THR A 195 12.631 20.779 44.191 39.68 AKT3 O
ATOM 420 CG2 THR A 195 11.420 19.199 45.571 37.88 AKT3 C
ATOM 421 C THR A 195 10.198 21.946 43.149 36 .17 AKT3 C
ATOM 422 O THR A 195 9.282 22.749 43.377 1.00 35 .02 AKT3 O ATOM 423 N GLU A 196 11.189 22.198 42.302 1.00 35.08 AKT3 N ATOM 424 CA GLU A 196 11.256 23.457 41.581 1.00 34.92 AKT3 C ATOM 425 CB GLU A 196 12.401 23.399 40.576 1.00 34.41 AKT3 C ATOM 426 CG GLU A 196 12.642 24.679 39.818 1.00 36.52 AKT3 C ATOM 427 CD GLU A 196 14.041 24.749 39.235 1.00 37.23 AKT3 C ATOM 428 OEl GLU A 196 14.477 23.752 38.612 1.00 38.12 AKT3 O ATOM 429 OE2 GLU A 196 14.700 25.802 39.396 38.22 AKT3 O ATOM 430 C GLU A 196 9.910 23.714 40.885 34.73 AKT3 C ATOM 431 O GLU A 196 9.375 24.817 40.943 35.18 AKT3 O ATOM 432 N SER A 197 9.349 22.687 40.260 34.61 AKT3 N ATOM 433 CA SER A 197 8.063 22.813 39.574 35.62 AKT3 C ATOM 434 CB SER A 197 7.883 21.658 38.585 37.27 AKT3 C ATOM 435 OS SER A 197 8.232 20.409 39.175 ,39.93 AKT3 O ATOM 436 C SER A 197 6.851 22.869 40.513 35.10 AKT3 C ATOM 437 O SER A 197 5.810 23.437 40.160 33.39 AKT3 O ATOM 438 N ARG A 198 6.980 22.278 41.701 35.70 AKT3 N ATOM 439 CA ARG A 198 5.879 22.284 42.665 36.31 AKT3 C ATOM 440 CB ARG A 198 6.197 21.439 43.909 39.54 AKT3 C ATOM 441 CG ARG A 198 6.926 20.116 43.672 44.00 AKT3 C ATOM 442 CD ARG A 198 7.539 19.588 44.991 46.63 AKT3 C ATOM 443 NE ARG A 198 6.552 18.939 45.870 48.46 AKT3 N ATOM 444 CZ ARG A 198 6.075 17.706 45.681 47.71 AKT3 C ATOM 445 NHl ARG A 198 6.494 16.983 44.648 46.99 AKT3 N ATOM 446 NH2 ARG A 198 5.177 17.197 46.518 47.36 AKT3 N ATOM 447 C ARG A 198 5.652 23.715 43.127 34.97 AKT3 C ATOM 448 O ARG A 198 4.520 24.110 43.389 33.99 AKT3 O ATOM 449 N VAL A 199 6.733 24.486 43.236 32.95 AKT3 N ATOM 450 CA VAL A 199 6.630 25.869 43.688 32.39 AKT3 C C ATOM 451 CB VAL A 199 7.976 26.388 44.217 30.72 AKT3 C C ATOM 452 CGl VAL A 199 7.838 27.832 44.639 29.02 AKT3 C ATOM 453 CG2 VAL A 199 8.430 25.548 45.394 30.61 AKT3 C ATOM 454 C VAL A 199 6.127 26.837 42.621 33.67 AKT3 C ATOM 455 O VAL A 199 5.475 27.833 42.947 33.37 AKT3 O ATOM 456 N LEU A 200 6.435 26.554 41.357 35.23 AKT3 N ATOM 457 CA LEU A 200 5.997 27.404 40.250 37.50 AKT3 C ATOM 458 CB LEU A 200 6.168 26.684 38.912 37.35 AKT3 C ATOM 459 CG LEU A 200 7.469 26.794 38.117 36.69 AKT3 C ATOM 460 CDl LEU A 200 7.999 28.234 38.222 36.65 AKT3 C ATOM 461 CD2 LEU A 200 8.480 25.797 38.634 37.23 AKT3 C ATOM 462 C LEU A 200 4.527 27.812 40.364 39.36 AKT3 C ATOM 463 O LEU A 200 4.187 28.966 40.641 41.10 AKT3 O ATOM 464 N LYS A 201 3.656 26.845 40.129 1.00 40.83 AKT3 N ATOM 465 CA LYS A 201 2.214 27.055 40.168 42.25 AKT3 C ATOM 466 CB LYS A 201 1.570 25.999 39.277 44.66 AKT3 C ATOM 467 CG LYS A 201 2.370 24.695 39.240 45.39 AKT3 C ATOM 468 CD LYS A 201 2.365 23.976 40.587 47.68 AKT3 C ATOM 469 CE LYS A 201 2.878 24.840 41.739 48.29 AKT3 C ATOM 470 NZ LYS A 201 4.276 25.355 41.597 47.14 AKT3 N ATOM 471 C LYS A 201 1.598 27.021 41.574 42.03 AKT3 C ATOM 472 O LYS A 201 0.530 26.444 41.789 42.22 AKT3 O ATOM 473 N ASN A 202 2.279 27.637 42.532 42.53 AKT3 N ATOM 474 CA ASN A 202 1.794 27.675 43.909 41.63 AKT3 C ATOM 475 CB ASN A 202 2.543 26.627 44.751 43.93 AKT3 C ATOM 476 CG ASN A 202 1.613 25.805 45.649 46.11 AKT3 C ATOM 477 ODl ASN A 202 0.532 25.376 45.223 47.81 AKT3 O ATOM 478 ND2 ASN A 202 2.043 25.564 46.893 47.74 AKT3 N ATOM 479 C ASN A 202 2.109 29.081 44.399 40.08 AKT3 C ATOM 480 O ASN A 202 1.655 29.516 45.461 40.19 AKT3 O ATOM 481 N THR A 203 2.886 29.793 43.591 37.29 AKT3 N ATOM 482 CA THR A 203 3.295 31.142 43.917 34.82 AKT3 C ATOM 483 CB THR A 203 4.774 31.180 44.305 34.54 AKT3 C ATOM 484 OGl THR A 203 5.548 30.584 43.255 32.81 AKT3 O ATOM 485 CG2 THR A 203 5.006 30.413 45.614 32.58 AKT3 C ATOM 486 C THR A 203 3.096 32.062 42.735 34.30 AKT3 C ATOM 487 O THR A 203 3.186 31.645 41.578 34.31 AKT3 O ATOM 488 N ARG A 204 2.807 33.320 43.037 33.33 AKT3 N ATOM 489 CA ARG A 204 2.619 34.316 42.006 31.92 AKT3 C ATOM 490 CB ARG A 204 1.130 34.544 41.756 35.00 AKT3 C ATOM 491 CG ARG A 204 0.782 34.723 40.286 39.57 AKT3 C ATOM 492 CD ARG A 204 -0.342 33.771 39.890 43.11 AKT3 C ATOM 493 NE ARG A 204 0.038 32.375 40.119 46.93 AKT3 N ATOM 494 CZ ARG A 204 -0.801 31.339 40.053 47.56 AKT3 C ATOM 495 NHl ARG A 204 -2.085 31.540 39.762 1.00 47.18 AKT3 N ATOM 496 NH2 ARG A 204 -0.359 30.103 40.283 1.00 47.01 AKT3 N
ATOM 497 C ARG A 204 3.288 35.599 42.485 1.00 29.31 AKT3 C
ATOM 498 O ARG A 204 2.966 36.127 43.553 1.00 28.23 AKT3 O
ATOM 499 N HIS A 205 4.235 36.086 41.693 1.00 26.48 AKT3 N
ATOM 500 CA HIS A 205 4.957 37.297 42.045 1.00 23.74 AKT3 C
ATOM 501 CB HIS A 205 6.098 36.957 42.996 1.00 20.96 AKT3 C
ATOM 502 CG HIS A 205 6.812 38.157 43.522 1.00 18.93 AKT3 C
ATOM 503 CD2 HIS A 205 7.751 38.949 42.959 1.00 16.62 AKT3 C
ATOM 504 NDl HIS A 205 6.544 38.696 44.759 1.00 16.64 AKT3 N
ATOM 505 CEl HIS A 205 7.287 39.771 44.937 1.00 18.84 AKT3 C
ATOM 506 NE2 HIS A 205 8.029 39.946 43.858 1.00 18.60 AKT3 N
ATOM 507 C HIS A 205 5.503 37.986 40.794 1.00 22.51 AKT3 C
ATOM 508 O HIS A 205 5.973 37.335 39.869 1.00 22.781 AKT3 O
ATOM 509 N PRO A 206 5.459 39.327 40.773 1.00 21.89 AKT3 N
ATOM 510 CD PRO A 206 5.058 40.127 41.945 1.00 20.68 AKT3 C
ATOM 511 CA PRO A 206 5.918 40.194 39.674 1.00 20.41 AKT3 C
ATOM 512 CB PRO A 206 5.812 41.605 40.264 1.00 19.43 AKT3 C
ATOM 513 CG PRO A 206 4.763 41.469 41.331 1.00 20.96 AKT3 C
ATOM 514 C PRO A 206 7.337 39.911 39.201 1.00 19.55 AKT3 C
ATOM 515 O PRO A 206 7.670 40.108 38.033 1.00 20.08 AKT3 O
ATOM 516 N PHE A 207 8.173 39.451 40.120 1.00 18.06 AKT3 N
ATOM 517 CA PHE A 207 9.560 39.207 39.800 1.00 17.37 AKT3 C
ATOM 518 CB PHE A 207 10.413 39.950 40.823 1.00 16.17 AKT3 C
ATOM 519 CG PHE A 207 10.019 41.391 40.970 1.00 15.63 AKT3 C
ATOM 520 CDl PHE A 207 9.895 42.197 39.855 1.00 15.89 AKT3 C
ATOM 521 CD2 PHE A 207 9.725 41.930 42.208 1.00 16.66 AKT3 C
ATOM 522 CEl PHE A 207 9.482 43.510 39.963 1.00 15.80 AKT3 C
ATOM 523 CE2 PHE A 207 9.310 43.252 42.324 1.00 17.02 AKT3 C
ATOM 524 CZ PHE A 207 9.190 44.038 41.196 • 1.00 16.75 AKT3 C
ATOM 525 C PHE A 207 9.932 37.738 39.677 1.00 17.52 AKT3 C
ATOM 526 O PHE A 207 11.101 37.380 39.535 1.00 17.50 AKT3 O
ATOM - 527 N LEU A 208 8.912 36.897 39.698 1.00 16.74 AKT3 N
ATOM 528 CA LEU A 208 9.092 35.470 39.551 1.00 18.15 AKT3 C
ATOM 529 CB LEU A 208 8.445 34.724 40.710 1.00 18.52 AKT3 C
ATOM 530 CG LEU A 208 9.143 34.906 42.052 1.00 22.61 AKT3 C
ATOM 531 CDl LEU A 208 8.361 34.221 43.171 1.00 21.89 AKT3 C
ATOM 532 CD2 LEU A 208 10.541 34.319 41.940 1.00 22.16 AKT3 C
ATOM 533 C LEU A 208 8.367 35.136 38.277 1.00 17.29 AKT3 C
ATOM 534 O LEU A 208 7.160 35.302 38.197 1.00 14.86 AKT3 O
ATOM 535 N THR A 209 9.104 34.702 37.266 1.00 18.93 AKT3 N
ATOM 53S CA THR A 209 8.466 34.343 36.015 1.00 20.09 AKT3 C
ATOM 537 CB THR A 209 9.500 34.041 34.917 1.00 20.45 AKT3 C
ATOM 538 OGl THR A 209 9.085 32.887 34.184 1.00 23.83 AKT3 O
ATOM 539 CG2 THR A 209 10.868 33.831 35.504 1.00 19.48 AKT3 C
ATOM 540 C THR A 209 7.SOl 33.122 36.299 1.00 21.03 AKT3 C
ATOM 541 O THR A 209 8.085 32.098 36.789 1.00 20.54 AKT3 O
ATOM 542 N SER A 210 6.312 33.248 35.998 1.00 21.24 AKT3 N
ATOM 543 CA SER A 210 5.351 32.193 36.274 1.00 22.86 AKT3 C
ATOM 544 CB SER A 210 3.957 32.817 36.464 1.00 23.50 AKT3 C
ATOM 545 OG SER A 210 3.629 33.710 35.419 1.00 20.51 AKT3 O
ATOM 546 C SER A 210 5.252 30.995 35.331 1.00 23.76 AKT3 C
ATOM 547 O SER A 210 5.562 31.072 34.145 1.00 23.38 AKT3 O
ATOM 548 N LEU A 211 4.815 29.878 35.904 1.00 25.10 AKT3 N
ATOM 549 CA LEU A 211 4.630 28.624 35.177 1.00 26.94 AKT3 C
ATOM 550 CB LEU A 211 4.954 27.421 36.077 1.00 26.42 AKT3 C
ATOM 551 CG LEU A 211 5.100 26.037 35.429 1.00 26.79 AKT3 C
ATOM 552 CDl LEU A 211 4.666 24.949 36.418 1.00 25.24 AKT3 C
ATOM 553 CD2 LEU A 211 4.255 25.968 34.177 1.00 25.76 AKT3 C
ATOM 554 C LEU A 211 3.160 28.563 34.764 1.00 27.34 AKT3 C
ATOM 555 O LEU A 211 2.272 28.631 35.609 1.00 26.73 AKT3 O
ATOM 556 N LYS A 212 2.910 28.455 33.464 1.00 28.99 AKT3 N
ATOM 557 CA LYS A 212 1.546 28.390 32.957 1.00 29.60 AKT3 C
ATOM 558 CB LYS A 212 1.485 28.939 31.538 1.00 30.96 AKT3 C
ATOM 559 CG LYS A 212 0.087 28.988 30.972 1.00 32.15 AKT3 C
ATOM 560 CD LYS A 212 -0.770 29.974 31.738 1.00 33.60 AKT3 C
ATOM 561 CE LYS A 212 -2.146 30.120 31.092 1.00 34.12 AKT3 C
ATOM 562 NZ LYS A 212 -3.015 31.076 31.849 1.00 33.51 AKT3 N
ATOM 563 C LYS A 212 1.064 26.946 32.953 1.00 29.80 AKT3 C
ATOM 564 O LYS A 212 0.128 26.581 33.668 1.00 30.19 AKT3 O
ATOM 565 N TYR A 213 1.718 26.119 32.152 1.00 29.55 AKT3 N
ATOM 566 CA TYR A 213 1.321 24.731 32.065 1.00 30.64 AKT3 C
ATOM 567 CB TYR A 213 0.679 24.457 30.715 1.00 30.82 AKT3 C
ATOM 568 CG TYR A 213 -0.524 25.310 30.384 1.00 29.14 AKT3 C ATOM 569 CDl TYR A 213 -1.752 25.101 31.001. 1.00 29.33 AKT3 C
ATOM 570 CEl TYR A 213 -2.878 25.820 30.617 1.00 29.20 AKT3 C
ATOM 571 CD2 TYR A 213 -0.449 26.268 29.388 1.00 30.58 AKT3 C
ATOM 572 CE2 TYR A 213 -1.566 26.994 28.999 1.00 30.59 AKT3 C
ATOM 573 ' CZ TYR A 213 -2.775 26.765 29.610 1.00 29.52 AKT3 C
ATOM 574 OH TYR A 213 -3.873 27.473 29.176 1.00 29.87 AKT3 O
ATOM 575 C TYR A 213 2.474 23.776 32.245 1.00 31.76 AKT3 C
ATOM 576 O TYR A 213 3.641 24.161 32.254 1.00 32.41 AKT3 O
ATOM 577 N SER A 214 2.125 22.510 32.396 1.00 34.32 AKT3 N
ATOM 578 CA SER A 214 3.108 21.445 32.551 1.00 35.47 AKT3 C
ATOM 579 CB SER A 214 3.454 21.219 34.029 1.00 35.69 AKT3 C
ATOM 580 OG SER A 214 4.343 22.216 34.503 1.00 38.35 AKT3 O
ATOM 581 C SER A 214 2.497 20.184 31.968 1.0O 35.47 AKT3 C
ATOM 582 O SER A 214 1.277 20.020 31.945 1.00 34.39 AKT3 O
ATOM 583 N PHE A 215 3.362 19.313 31.476 1.00 36.42 AKT3 N
ATOM 584 CA PHE A 215 2.975 18.041 30.892 1.00 37.07 AKT3 C
ATOM 585 CB PHE A 215 1.971 18.202 29.742 1.00 35.25 AKT3 C
ATOM 586 CG PHE A 215 2.472 19.034 28.602 1.00 34.47 AKT3 C
ATOM 587 CDl PHE A 215 2.090 20.359 28.473 1.00 33.76 AKT3 C
ATOM 588 CD2 PHE A 215 3.297 18.487 27.639 1.00 34.90 AKT3 C
ATOM 589 CEl PHE A 215 2.518 21.126 27.403 1.00 33.18 AKT3 C
ATOM 590 CE2 PHE A 215 3.735 19.253 26.556 1.00 34.52 AKT3 C
ATOM 591 CZ PHE A 215 3.341 20.576 26.442 1.00 33.60 AKT3 C
ATOM 592 C PHE A 215 4.268 17.470 30.367 1.00 38.42 AKT3 C
ATOM 593 O PHE A 215 5.280 18.179 30.284 1.00 37.52 AKT3 O
ATOM 594 N GLN A 216 4.236 16.191 30.020 1.00 39.76 AKT3 N
ATOM 595 CA GLN A 216 5.419 15.526 29.525 1.00 41.57 AKT3 C
ATOM 596 CB GLN A 216 5.960 14.582 30.607 1.00 42.53 AKT3 C
ATOM 597 CG GLN A 216 4.877 13.864 31.441 1.00 44.10 AKT3 C
ATOM 598 CD GLN A 216 4.568 14.542 32.783 1.00 45.43 AKT3 C
ATOM 599 OEl GLN A 216 4.067 15.673 32.831 1.00 45.98 AKT3 O
ATOM 600 NE2 GLN A 216 4.864 13.843 33.882 1.00 45.04 AKT3 N
ATOM 601 C GLN A 216 5.097 14.762 28.250 1.00 42.06 AKT3 C
ATOM 602 O GLN A 216 3.961 14.780 27.774 1.00 42.11 AKT3 O
ATOM 603 N THR A 217 6.103 14.106 27.687 1.00 43.24 AKT3 N
ATOM 604 CA THR A 217 5.912 13.324 26.472 1.00 44.90 AKT3 C
ATOM 605 CB THR A 217 6.357 14.108 25.204 1.00 44.16 AKT3 C
ATOM S06 OGl THR A 217 7.724 14.531 25.345 1.00 42.70 AKT3 O
ATOM 607 CG2 THR A 217 5.457 15.322 24.984 1.00 43.16 AKT3 C
ATOM 608 C THR A 217 6.746 12.053 26.584 1.00 46.61 AKT3 C
ATOM 609 O THR A 217 7.079 11.609 27.690 1.00 46.95 AKT3 O
ATOM 610 N LYS A 218 7.067 11.459 25.439 1.00 48.02 AKT3 N
ATOM 611 CA LYS A 218 7.880 10.254 25.430 1.00 48.43 AKT3 C
ATOM 612 CB LYS A 218 8.604 10.105 24.079 1.00 49.02 AKT3 C
ATOM 613 CG LYS A 218 9.226 11.390 23.542 1.00 48.91 AKT3 C
ATOM 614 CD LYS A 218 8.185 12.494 23.424 1.00 47.95 AKT3 C
ATOM 615 CE LYS A 218 8.774 13.734 22.789 1.00 48.60 AKT3 C
ATOM 616 NZ LYS A 218 10.120 14.041 23.350 1.00 48.52 AKT3 N
ATOM 617 C LYS A 218 8.870 10.438 26.565 1.00 47.75 AKT3 C
ATOM 618 O LYS A 218 8.641 9.948 27.671 1.00 48.33 AKT3 O
ATOM 619 N ASP A 219 9.940 11.184 26.311 1.00 46.89 AKT3 N
ATOM 620 CA ASP A 219 10.950 11.423 27.340 1.00 46.12 AKT3 C
ATOM 621 CB ASP A 219 12.140 10.502 27.097 1.00 47.42 AKT3 C
ATOM 622 CG ASP A 219 12.183 9.993 25.673 1.00 48.23 AKT3 C
ATOM 623 ODl ASP A 219 12.201 10.838 24.745 1.00 47.73 AKT3 O
ATOM 624 OD2 ASP A 219 12.187 8.752 25.492 1.00 48.10 AKT3 O
ATOM 625 C ASP A 219 11.414 12.883 27.401 1.00 44.35 AKT3 C
ATOM 626 O ASP A 219 12.595 13.176 27.218 1.00 44.00 AKT3 O
ATOM 627 N ARG A 220 10.477 13.788 27.677 1.00 42.72 AKT3 N
ATOM 628 CA ARG A 220 10.786 15.205 27.762 1.00 41.16 AKT3 C
ATOM 629 CB ARG A 220 10.758 15.815 26.367 1.00 41.21 AKT3 C
ATOM 630 CG ARG A 220 11.750 15.163 25.459 1.00 42.96 AKT3 C
ATOM 631 CD ARG A 220 11.907 15.855 24.128 1.00 43.57 AKT3 C
ATOM 632 NE ARG A 220 13.034 15.245 23.435 1.00 45.04 AKT3 N
ATOM 633 CZ ARG A 220 14.281 15.265 23.905 1.00 46.91 AKT3 C
ATOM 634 NHl ARG A 220 14.544 15.874 25.063 1.00 46.71 AKT3 N
ATOM 535 NH2 ARG A 220 15.264 14.670 23.232 1.00 46.35 AKT3 N
ATOM 636 C ARG A 220 9.833 15.968 28.673 1.00 39.75 AKT3 C
ATOM 637 O ARG A 220 8.617 15.755 28.646 1.00 39.79 AKT3 O
ATOM 638 N LEU A 221 10.388 16.849 29.496 1.00 38.36 AKT3 N
ATOM 639 CA LEU A 221 9.563 17.651 30.388 1.00 37.26 AKT3 C
ATOM 640 CB LEU A 221 10.257 17.885 31.737 1.00 38.43 AKT3 C
ATOM 641 CG LEU A 221 9.929 16.827 32.799 1.00 39.80 AKT3 C ATOM 542 CDl LEU A 221 10.523 15.480 32.387 1.00 39.93 AKT3 C
ATOM 643 CD2 LEU A 221 10.465 17.274 34.163 1.00 40.25 AKT3 C
ATOM 644 C LEU A 221 9.278 18.973 29.708 1.00 35.30 AKT3 C
ATOM 645 0 LEU A 221 10.179 19.613 29.162 1.00 34.06 AKT3 O
ATOM 646 N CYS A 222 8.011 19.362 29.742 1.00 33.81 AKT3 N
ATOM 647 CA CYS A 222 7.560 20.587 29.121 1.00 32.29 AKT3 C
ATOM 648 CB CYS A 222 6.526 20.261 28.043 1.00 33.28 AKT3 C
ATOM 649 SG CYS A 222 7.174 19.276 26.670 1.00 34.63 AKT3 S
ATOM 650 C CYS A 222 6.964 21.557 30.129 1.00 31.64 AKT3 C
ATOM 651 O CYS A 222 5.921 21.291 30.741 1.00 31.39 AKT3 O
ATOM 652 N PHE A 223 7.636 22.692 30.290 1.00 30.82 AKT3 N
ATOM 653 CA PHE A 223 7.185 23.734 31.204 1.00 27.78 AKT3 C
ATOM 654 CB PHE A 223 8.253 24.003 32.258 1.00 27.02 AKT3 C
ATOM 655 CG PHE A 223 8.459 22.853 33.198 1.00 27.48 AKT3 C
ATOM 656 CDl PHE A 223 7.440 22.453 34.049 1.00 26.64 AKT3 C
ATOM 657 CD2 PHE A 223 9.658 22.160 33.217 1.00 27.36 AKT3 C
ATOM 658 CEl PHE A 223 7.610 21.387 34.895 1.00 27.39 AKT3 C
ATOM 659 CE2 PHE A 223 9.835 21.091 34.062 1.00 27.92 AKT3 C
ATOM 660 CZ PHE A 223 8.808 20.701 34.905 1.00 27.16 AKT3 C
ATOM 661 C PHE A 223 6.901 24.981 30.401 1.00 26.19 AKT3 C
ATOM 662 O PHE A 223 7.808 25.619 29.872 1.00 25.49 AKT3 O
ATOM 663 N VAL A 224 5.623 25.310 30.300 1.00 25.25 AKT3 N
ATOM 664 CA VAL A 224 5.189 26.466 29.546 1.00 25.07 AKT3 C
ATOM 665 CB VAL A 224 3.795 26.231 28.964 1.00 25.88 AKT3 C
ATOM 666 CGl VAL A 224 3.555 27.180 27.798 1.00 25.90 AKT3 C
ATOM 667 CG2 VAL A 224 3.659 24.765 28.531 1.00 25.69 AKT3 C
ATOM 668 C VAL A 224 5.157 27.655 30.484 1.00 25.46 AKT3 C
ATOM 669 O VAL A 224 4.302 27.736 31.366 1.00 26.48 AKT3 O
ATOM 670 N MET A 225 6.088 28.584 30.275 1.00 24.58 AKT3 N
ATOM 671 CA MET A 225 6.202 29.763 31.117 1.00 23.40 AKT3 C
ATOM 672 CB MET A 225 7.579 29.757 31.765 1.00 22.63 AKT3 C
ATOM 673 CG MET A 225 7.862 28.443 32.478 1.00 24.23 AKT3 C
ATOM 674 SD MET A 225 9.590 28.119 32.825 1.00 24.84 AKT3 S
ATOM 675 CE MET A 225 9.957 29.465 33.983 1.00 23.33 AKT3 C
ATOM 676 C MET A 225 5.987 31.051 30.343 1.00 23.66 AKT3 C
ATOM 677 O MET A 225 6.022 31.064 29.107 1.00 21.83 AKT3 O
ATOM 678 N GLU A 226 5.751 32.134 31.076 1.00 23.41 AKT3 N
ATOM 679 CA GLU A 226 5.537 33.426 30.443 1.00 24.60 AKT3 C
ATOM 680 CB GLU A 226 5.222 34.503 31.491 1.00 24.50 AKT3 C
ATOM 681 CG GLU A 226 6.411 35.045 32.272 1.00 25.73 AKT3 C
ATOM 682 CD GLU A 226 5.984 35.965 33.422 1.00 26.71 AKT3 C
ATOM 683 OEl GLU A 226 5.802 35.456 34.548 1.00 25.31 AKT3 O
ATOM 684 OE2 GLU A 226 5.821 37.192 33.194 1.00 26.33 AKT3 O
ATOM 685 C GLU A 226 6.807 33.775 29.678 1.00 25.03 AKT3 C
ATOM 686 O GLU A 226 7.883 33.268 29.987 1.00 25.17 AKT3 O
ATOM 687 N TYR A 227 6.670 34.625 28.670 1.00 25.93 AKT3 N
ATOM 688 CA TYR A 227 7.802 35.035 27.847 1.00 26.18 AKT3 C
ATOM 689 CB TYR A 227 7.353 35.108 26.375 1.00 25.93 AKT3 C
ATOM 690 CG TYR A 227 8.400 35.581 25.390 1.00 26.35 AKT3 C
ATOM 691 CDl TYR A 227 9.590 34.881 25.222 1.00 26.51 AKT3 C
ATOM 692 CEl TYR A 227 10.547 35.303 24.325 1.00 25.44 AKT3 C
ATOM 693 CD2 TYR A 227 8.195 36.726 24.619 1.00 26.03 AKT3 C
ATOM 694 CE2 TYR A 227 9.147 37.157 23.712 1.00 26.16 AKT3 C
ATOM 695 CZ TYR A 227 10.325 36.439 23.572 1.00 26.99 AKT3 C
ATOM 696 OH TYR A 227 11.292 36.856 22.690 1.00 25.31 AKT3 O
ATOM 697 C TYR A 227 8.325 36.391 28.326 1.00 25.69 AKT3 C
ATOM 698 O TYR A 227 7.546 37.318 28.552 1.00 26.44 AKT3 O
ATOM 699 N VAL A 228 9.638 36.493 28.511 1.00 25.04 AKT3 N
ATOM 700 CA VAL A 228 10.253 37.744 28.947 1.00 25.54 AKT3 C
ATOM 701 CB VAL A 228 10.892 37.624 30.376 1.00 24.99 AKT3 C
ATOM 702 CGl VAL A 228 9.981 36.829 31.301 1.00 24.56 AKT3 C
ATOM 703 CG2 VAL A 228 12.245 36.967 30.299 1.00 25.73 AKT3 C
ATOM 704 C VAL A 228 11.330 37.996 27.902 1.00 25.97 AKT3 C
ATOM 705 O VAL A 228 12.221 37.161 27.710 1.00 26.98 AKT3 0
ATOM 706 N ASM A 229 11.248 39.128 27.210 1.00 25.51 AKT3 N
ATOM 707 CA ASN A 229 12.217 39.411 26.159 1.00 25.50 AKT3 C
ATOM 708 CB ASN A 229 11.491 39.825 24.877 1.00 26.97 AKT3 C
ATOM 709 CG ASN A 229 10.584 41.015 25.080 1.00 28.49 AKT3 C
ATOM 710 ODl ASN A 229 10.309 41.769 24.142 1.00 29.91 AKT3 O
ATOM 711 ND2 ASN A 229 10.101 41.187 26.305 1.00 27.00 AKT3 N
ATOM 712 C ASN A 229 13.269 40.452 26.512 1.00 24.66 AKT3 C
ATOM 713 O ASN A 229 14.013 40.909 25.646 1.00 22.29 AKT3 O
ATOM 714 N GLY A 230 13.341 40.809 27.792 1.00 24.02 AKT3 N ATOM 715 CA GLY A 230 14.318 41.793 28.220 1.00 22.72 AKT3 C
ATOM 716 C GLY A 230 15.720 41.241 28.103 1.00 21.74 AKT3 C
ATOM 717 O GLY A 230 16.690 41.996 28.144 1.00 21.92 AKT3 O
ATOM 718 N GLY A 231 15.815 39.919 27.957 1.00 21.30 AKT3 N
ATOM 719 CA GLY A 231 17.103 39.255 27.835 1.00 21.59 AKT3 C
ATOM 720 C GLY A 231 17.679 38.783 29.162 1.00 22.78 AKT3 C
ATOM 721 O GBY A 231 17.260 39.235 30.227 1.00 23.04 AKT3 O
ATOM 722 N GLU A 232 18.648 37.872 29.098 1.00 24.14 AKT3 N
ATOM 723 CA GLU A 232 19.294 37.333 30.296 1.00 25.43 AKT3 C
ATOM 724 CB GLU A 232 19.881 35.942 30.004 1.00 25.36 AKT3 C
ATOM 725 CG GLU A 232 18.852 34.803 29.995 1.00 28.36 AKT3 C
ATOM 726 CD GLU A 232 19.491 33.405 30.004 1.00 30.18 AKT3 C
ATOM 727 OEl GLU A 232 20.196 33.051 29.029 1.00 30.82 AKT3 O
ATOM 728 OE2 GLU A 232 19.292 32.658 30.988 1.00 31.28 AKT3 O
ATOM 729 C GLU A 232 20.387 38.257 30.854 1.00 25.69 AKT3 C
ATOM 730 O GLU A 232 21.225 38.768 30.106 1.00 26.07 AKT3 O
ATOM 731 N LEU A 233 20.368 38.455 32.172 1.00 25.54 AKT3 N
ATOM 732 CA LEU A 233 21.329 39.316 32.867 1.00 26.95 AKT3 C
ATOM 733 CB LEU A 233 21.038 39.322 34.377 1.00 26.53 AKT3 C
ATOM 734 CG LEU A 233 20.117 40.379 34.994 1.00 26.77 AKT3 C
ATOM 735 CDl LEU A 233 20.642 41.775 34.659 1.00 26.95 AKT3 C
ATOM 736 CD2 LEU A 233 18.69$ 40.208 34.471 1.00 29.41 AKT3 C
ATOM 737 C LEU A 233 22.791 38.923 32.663 1.00 27.42 AKT3 C
ATOM 738 O LEU A 233 23.663 39.769 32.474 1.00 28.12 AKT3 O
ATOM 739 N PHE A 234 23.055 37.628 32.735 1.00 27.95 AKT3 N
ATOM 740 CA PHE A 234 24.403 37.120 32.573 1.00 29.01 AKT3 C
ATOM 741 CB PHE A 234 24.344 35.586 32.533 1.00 30.69 AKT3 C
ATOM 742 CG PHE A 234 25.656 34.931 32.249 1.00 32.52 AKT3 C
ATOM 743 CDl PHE A 234 26.100 34.781 30.943 1.00 33.98 AKT3 .C
ATOM 744 CD2 PHE A 234 26.461 34.481 33.292 1.00 34.19 AKT3 C
ATOM 745 CEl PHE A 234 27.326 34.194 30.676 1.00 35.59 AKT3 C
ATOM 746 CE2 PHE A 234 27.688 33.896 33.042 1.00 33.84 AKT3 C
ATOM 747 CZ PHE A 234 28.126 33.750 31.732 1.00 35.72 AKT3 C
ATOM 748 C PHE A 234 25.043 37.704 31.312 1.00 27.85 ARTS' C
ATOM 749 O PHE A 234 26.258 37.846 31.217 1.00 28.15 AKT3 O
ATOM 750 N PHE A 235 24.208 38.066 30.350 1.00 28.20 AKT3 N
ATOM 751 CA PHE A 235 24.690 38.633 29.100 1.00 28.02 AKT3 C
ATOM 752 CB PHE A 235 23.725 38.276 27.978 1.00 30.51 AKT3 C
ATOM 753 CG PHE A 235 23.670 36.812 27.709 1.00 35.34 AKT3 C
ATOM 754 CDl PHE A 235 22.584 36.238 27.065 1.00 37.76 AKT3 C
ATOM 755 CD-2 PHE A 235 24.719 35.991 28.118 1.00 36.56 AKT3 C
ATOM 756 CEl PHE A 235 22.546 34.855 26.834 1.00 38.30 AKT3 C
ATOM 757 CE2 PHE A 235 24.688 34.618 27.892 1.00 37.37 AKT3 C
ATOM 758 CZ PHE A 235 23.604 34.049 27.252 1.00 37.51 AKT3 C
ATOM 759 C PHE A 235 24.853 40.128 29.211 1.00 26.55 AKT3 C
ATOM 760 O PHE A 235 25.829 40.692 28.716 1.00 25.90 AKT3 O
ATOM 761 N HIS A 236 23.892 40.770 29.860 1.00 25.06 AKT3 N
ATOM 762 CA HIS A 236 23.948 42.204 30.054 1.00 24.39 AKT3 C
ATOM 763 CB HIS A 236 22.694 42.685 30.786 1.00 24.46 AKT3 C
ATOM 764 CG HIS A 236 21.444 42.622 29.958 1.00 24.44 AKT3 C
ATOM 765 CD2 HIS A 236 20.375 41.790 30.018 1.00 24.96 AKT3 C
ATOM 766 NDl HIS A 236 21.190 43.496 28.922 1.00 23.87 AKT3 N
ATOM 767 CEl HIS A 236 20.020 43.207 28.380 1.00 24.63 AKT3 C
ATOM 768 NE2 HIS A 236 19.505 42.176 29.026 1.00 26.02 AKT3 N
ATOM 769 C HIS A 236 25.197 42.543 30.861 1.00 23.80 AKT3 C
ATOM 770 O HIS A 236 25.967 43.425 30.494 1.00 23.42 AKT3 O
ATOM 771 N LEU A 237 25.410 41.832 31.958 1.00 24.92 AKT3 N
ATOM 111 CA LEU A 237 26.580 42.100 32.779 1.00 26.42 AKT3 C
ATOM 773 CB LEU A 237 26.493 41.371 34.122 1.00 23.94 AKT3 C
ATOM 774 CG LEU A 237 27.709 41.655 35.019 1.00 24.65 AKT3 C
ATOM 775 CDl LEU A 237 27.777 43.156 35.294 1.00 23.19 AKT3 C
ATOM 776 CD2 LEU A 237 27.627 40.856 36.328 1.00 20.68 AKT3 C
ATOM 777 C LEU A 237 27.812 41.632 32.022 1.00 27.90 AKT3 C
ATOM 778 O LEU A 237 28.932 42.024 32.329 1.00 29.06 AKT3 O
ATOM 779 N SER A 238 27.586 40.792 31.024 1.00 29.84 AKT3 N
ATOM 780 CA SER A 238 28.664 40.252 30.210 1.00 31.49 AKT3 C
ATOM 781 CB SER A 238 28.201 38.976 29.508 1.00 31.48 AKT3 C
ATOM 782 OG SER A 238 29.213 38.492 28.645 1.00 33.18 AKT3 O
ATOM 783 C SER A 238 29.129 41.257 29.168 1.00 32.64 AKT3 C
ATOM 784 O SER A 238 30.288 41.251 28.750 1.00 33.52 AKT3 O
ATOM 785 N ARG A 239 28.215 42.112 28.738 1.00 32.68 AKT3 N
ATOM 786 CA ARG A 239 28.546 43.119 27.756 1.00 32.41 AKT3 C
ATOM 787 CB ARG A 239 27.392 43.282 26.757 1.00 34.79 AKT3 C ATOM 788 CG ARG A 239 27.246 44.692 26.180 1.00 37.84 AKT3 C
ATOM 789 CD ARG A 239 26.339 45.567 27.053 1.00 40.25 AKT3 C
ATOM 790 NE ARG A 239 25.032 44.930 27.251 1.00 43.60 AKT3 N
ATOM 791 CZ ARG A 239 23.987 45.483 27.877 1.00 43.78 AKT3 C
ATOM 792 NHl ARG A 239 24.063 46.711 28.38$ 1.00 42.34 AKT3 N
ATOM 793 NH2 ARG A 239 22.857 44.792 27.999 1.00 42.48 AKT3 N
ATOM 794 C ARG A 239 28.861 44.447 28.431 1.00 31.45 AKT3 C
ATOM 795 O ARG A 239 29.179 45.433 27.768 1.00 32.54 AKT3 O
ATOM 796 N GLU A 240 28.776 44.484 29.751 1.00 30.35 AKT3 N
ATOM 797 CA GLU A 240 29.067 45.718 30.457 1.00 29.28 AKT3 C
ATOM 798 CB GLU A 240 27.812 46.286 31.070 1.00 31.50 AKT3 C
ATOM 799 CG GLU A 240 26.761 46.600 30.073 1.00 33.60 AKT3 C
ATOM 800 CD GLU A 240 25.735 47.509 30.665 1.00 36.58 AKT3 C
ATOM 801 OEl GLU A 240 26.056 48.703 30.871 1.00 37.36 AKT3 O
ATOM 802 OE2 GLU A 240 24.621 47.020 30.943 1.00 37.80 AKT3 O
ATOM 803 C GLU A 240 30.093 45.520 31.540 1.00 27.86 AKT3 C
ATOM 804 O GLU A 240 30.553 46.487 32.152 1.00 27.40 AKT3 O
ATOM 805 N ARG A 241 30.429 44.255 31.769 1.00 26.83 AKT3 N
ATOM 80S CA ARG A 241 31.417 43.850 32.758 1.00 26.40 AKT3 C
ATOM 807 CB ARG A 241 32.769 44.510 32.456 1.00 27.69 AKT3 C
ATOM 808 CG ARG A 241 33.348 44.196 31.072 1.00 31.73 AKT3 C
ATOM 809 CD ARG A 241 33.679 42.710 30.867 1.00 33.20 AKT3 C
ATOM 810 NE ARG A 241 32.480 41.874 30.803 1.00 36.31 AKT3 N
ATOM 811 CZ ARG A 241 32.472 40.572 30.516 1.00 37.42 AKT3 C
ATOM 812 NHl ARG A 241 33.609 39.925 30.258 1.00 36.87 AKT3 N
ATOM 813 NH2 ARG A 241 31.315 39.914 30.478 1.00 38.16 AKT3 N
ATOM 814 C ARG A 241 31.009 44.134 34.201 1.00 24.59 AKT3 C
ATOM 815 O ARG A 241 31.271 43.316 35.082 1.00 25.15 AKT3 O
ATOM 816 N VAL A 242 30.371 45.278 34.437 1.00 20.70 AKT3 N
ATOM 817 CA VAI. A 242 29.938 45.657 35.775 1.00 19.44 AKT3 C
ATOM 818 CB VAL A 242 31.108 46.309 36.555 1.00 18.54 AKT3 C
ATOM 819 CGl VAL A 242 31.599 47.544 35.830 1.00 17.63 AKT3 C
ATOM 820 CG2 VAL A 242 30.679 46.666 37.953 1.00 17.40 AKT3 C
ATOM 821 C VAL A 242 28.749 46.625 35.740 1.00 19.31 AKT3 C
ATOM 822 O VAL A 242 28.637 47.448 34.836 1.00 20.09 AKT3 O
ATOM 823 N PHE A 243 27.850 46.508 36.712 1.00 17.83 AKT3 N
ATOM 824 CA PHE A 243 26.698 47.398 36.792 1.00 17.71 AKT3 C
ATOM 825 CB PHE A 243 25.415 46.648 37.175 1.00 17.63 AKT3 C
ATOM 826 CG PHE A 243 24.884 45.740 36.099 1.00 18.98 AKT3 C
ATOM 827 CDl PHE A 243 25.098 46.019 34.762 1.00 18.66 AKT3 C
ATOM 828 CD2 PHE A 243 24.139 44.624 36.434 1.00 17.48 AKT3 C
ATOM 829 CEl PHE A 243 24.578 45.199 33.779 1.00 20.15 AKT3 C
ATOM 830 CE2 PHE A 243 23.616 43.805 35.460 1.00 20.60 AKT3 C
ATOM 831 CZ PHE A 243 23.835 44.089 34.128 1.00 19.14 AKT3 C
ATOM 832 C PHE A 243 26.963 48.427 37.867 1.00 17.94 AKT3 C
ATOM 833 O PHE A 243 27.785 48.210 38.754 1.00 17.67 AKT3 O
ATOM 834 N SER A 244 26.248 49.542 37.800 1.00 17.72 AKT3 N
ATOM 835 CA SER A 244 26.398 50.593 38.793 1.00 18.03 AKT3 C
ATOM 836 CB SER A 244 25.753 51.884 38.295 1.00 17.61 AKT3 C
ATOM 837 OG SER A 244 24.387 51.661 38.003 1.00 21.15 AKT3 O
ATOM 838 C SER A 244 25.738 50.145 40.098 1.00 17.26 AKT3 C
ATOM 839 O SER A 244 24.961 49.193 40.126 1.00 15.37 AKT3 O
ATOM 840 N GLU A 245 26.050 50.841 41.180 1.00 17.05 AKT3 N
ATOM 841 CA GLU A 245 25.495 50.493 42.476 1.00 18.75 AKT3 C
ATOM 842 CB GLU A 245 26.202 51.286 43.583 1.00 17.64 AKT3 C
ATOM 843 CG GLU A 245 27.663 50.873 43.746 1.00 19.25 AKT3 C
ATOM 844 CD GLU A 245 28.316 51.386 45.020 1.00 21.59 AKT3 C
ATOM 845 OEl GLU A 245 27.612 51.523 46.047 1.00 21.04 AKT3 O
ATOM 846 OE2 GLU A 245 29.546 51.624 44.999 1.00 21.97 AKT3 O
ATOM 847 C GLU A 245 24.000 50.718 42.505 1.00 18.32 AKT3 C
ATOM 848 O GLU A 245 23.266 49.925 43.073 1.00 18.25 AKT3 O
ATOM 849 N ASP A 246 23.545 51.792 41.875 1.00 20.29 AKT3 N
ATOM 850 CA ASP A 246 22.121 52.075 41.838 1.00 22.41 AKT3 C
ATOM 851 CB ASP A 246 21.867 53.502 41.340 1.00 24.51 AKT3 C
ATOM 852 CG ASP A 246 20.409 53.946 41.543 1.00 28.99 AKT3 C
ATOM 853 ODl ASP A 246 19.864 54.645 40.657 1.00 30.43 AKT3 O
ATOM 854 OD2 ASP A 246 19.808 53.604 42.592 1.00 29.32 AKT3 O
ATOM 855 C ASP A 246 21.438 51.069 40.904 1.00 22.60 AKT3 C
ATOM 856 O ASP A 246 20.267 50.724 41.088 1.00 21.97 AKT3 O
ATOM 857 N ARG A 247 22.175 50.598 39.899 1.00 23.10 AKT3 N
ATOM 858 CA ARG A 247 21.620 49.637 38.954 1.00 21.70 AKT3 C
ATOM 859 CB ARG A 247 22.535 49.475 37.739 1.00 21.80 AKT3 C
ATOM 860 CG ARG A 247 22.123 48.305 36.866 1.00 22.71 AKT3 C ATOM 861 CD ARG A 247 22.037 48.658 35.392 1.00 20.95 AKT3 C
ATOM 862 NE ARG A 247 21.372 47.586 34.654 1.00 22.19 AKT3 N
ATOM 863 CZ ARG A 247 21.697 47.209 33.420 1.00 21.54 AKT3 C
ATOM 864 NHl ARG A 247 22.681 47.823 32.779 1.00 20.51 AKT3 N
ATOM 865 NH2 ARG A 247 21.054 46.201 32.839 1.00 19.11 AKT3 N
ATOM 866 C ARG A 247 21.447 48.300 39.649 1.00 21.36 AKT3 C
ATOM 867 O ARG A 247 20.452 47.596 39.454 1.00 21.71 AKT3 O
ATOM 868 N THR A 248 22.440 47.968 40.463 1.00 20.36 AKT3 N
ATOM 869 CA THR A 248 22.457 46.734 41.230 1.00 18.31 AKT3 C
ATOM 870 CB THR A 248 23.858 46.531 41.868 1.00 16.53 AKT3 C
ATOM 871 OGl THR A 248 24.854 46.586 40.846 1.0O 12.39 AKT3 O
ATOM 872 CG2 THR A 248 23.950 45.195 42.578 1.00 15.48 AKT3 C
ATOM 873 C THR A 248 21.384 46.837 42.323 1.00 18.42 AKT3 C
ATOM 874 O THR A 248 20.663 45.880 42.596 1.00 20.63 AKT3 O
ATOM 875 N ARG A 249 21.290 48.012 42.937 1.00 16.77 AKT3 N
ATOM 876 CA ARG A 249 20.315 48.287 43.988 1.00 15.50 AKT3 C
ATOM 877 CB ARG A 249 20.380 49.767 44.373 1.00 16.38 AKT3 C
ATOM 878 CG ARG A 249 19.446 50.199 45.484 1.00 17.13 AKT3 C
ATOM 879 CD ARG A 249 19.393 51.712 45.526 1.00 20.36 AKT3 C
ATOM 880 NE ARG A 249 20.727 52.293 45.352 1.00 24.47 AKT3 N
ATOM 881 CZ ARG A 249 21.623 52.408 46.325 1.00 24.67 AKT3 C
ATOM 882 NHl ARG A 249 21.321 51.994 47.543 1.00 24.98 AKT3 N
ATOM 883 NH2 ARG A 249 22.822 52.913 46.079 1.00 23.02 AKT3 N
ATOM 884 C ARG A 249 18.917 47.953 43.487 1.00 14.26 AKT3 C
ATOM 885 O ARG A 249 18.143 47.282 44.166 1.00 11.92 AKT3 O
ATOM 886 N PHE A 250 18.603 48.444 42.295 1.00 12.87 AKT3 N
ATOM 887 CA PHE A 250 17.319 48.195 41.675 1.00 11.83 AKT3 C
ATOM 888 CB PHE A 250 17.279 48.854 40.299 1.00 12.18 AKT3 C
ATOM 889 CG PHE A 250 16.049 48.531 39.517 1.00 13.78 AKT3 C
ATOM 890 CDl PHE A 250 14.838 49.105 39.839 1.00 13.61 AKT3 C
ATOM 891 CD2 PHE A 250 16.093 47.616 38.481 1.00 15.92 AKT3 C
ATOM 892 CEl PHE A 250 13.695 48.772 39.149 1.00 14.93 AKT3 C
ATOM 893 CE2 PHE A 250 14.948 47.279 37.786 1.00 15.04 AKT3 C
ATOM 894 CZ PHE A 250 13.752 47.857 38.122 1.00 15.41 AKT3 C
ATOM 895 C PHE A 250 17.042 46.689 41.534 1.00 12.73 AKT3 C
ATOM 896 O PHE A 250 15.997 46.194 41.945 1.00 11.55 AKT3 O
ATOM 897 N TYR A 251 17.983 45.960 40.951 1.00 13.00 AKT3 N
ATOM 898 CA TYR A 251 17.793 44.530 40.776 1.00 14.10 AKT3 C
ATOM 899 CB TYR A 251 18.925 43.929 39.933 1.00 14.37 AKT3 C
ATOM 900 CG TYR A 251 18.944 44.453 38.513 1.00 13.89 AKT3 C
ATOM 901 CDl TYR A 251 17.765 44.838 37.887 1.00 14.22 AKT3 C
ATOM 902 CEl TYR A 251 17.763 45.322 36.591 1.00 16.25 AKT3 C
ATOM 903 CD2 TYR A 251 20.129 44.562 37.799 1.00 13.72 AKT3 C
ATOM 904 CE2 TYR A 251 20.139 45.046 36.500 1.00 13.44 AKT3 C
ATOM 905 CZ TYR A 251 18.948 45.427 35.903 1.00 16.83 AKT3 C
ATOM 906 OH TYR A 251 18.931 45.945 34.633 1.00 17.44 AKT3 O
ATOM 907 C TYR A 251 17.705 43.833 42.115 1.00 14.09 AKT3 C
ATOM 908 O TYR A 251 16.824 43.009 42.331 1.00 16.08 AKT3 O
ATOM 909 N GLY A 252 18.611 44.181 43.019 1.00 13.25 AKT3 N
ATOM 910 CA GIiY A 252 18.612 43.574 44.334 1.00 12.16 AKT3 C
ATOM 911 C GLY A 252 17.302 43.758 45.067 1.00 10.94 AKT3 C
ATOM 912 O GLY A 252 16.762 42.809 45.619 1.00 11.26 AKT3 O
ATOM 913 N ALA A 253 16.790 44.982 45.065 1.00 11.01 AKT3 N
ATOM 914 CA ALA A 253 15.541 45.298 45.740 1.00 11.11 AKT3 C
ATOM 915 CB ALA A 253 15.220 46.764 45.568 1.00 8.28 AKT3 C
ATOM 916 C ALA A 253 14.387 44.439 45.227 1.00 13.57 AKT3 C
ATOM 917 O ALA A 253 13.616 43.895 46.015 1.00 12.86 AKT3 O
ATOM 918 N GLU A 254 14.268 44.322 43.906 1.00 14.46 AKT3 N
ATOM 919 CA GLU A 254 13.207 43.510 43.318 1.00 14.18 AKT3 C
ATOM 920 CB GLU A 254 13.198 43.655 41.803 1.00 13.46 AKT3 C
ATOM 921 CG GLU A 254 12.891 45.064 41.346 1.00 14.64 AKT3 C
ATOM 922 CD GLU A 254 12.393 45.110 39.924 1.00 13.60 AKT3 C
ATOM 923 OEl GLU A 254 12.994 44.429 39.075 1.00 13.26 AKT3 O
ATOM 924 OE2 GLU A 254 11.407 45.829 39.662 1.00 13.65 AKT3 O
ATOM 925 C GLU A 254 13.382 42.048 43.703 1.00 14.19 AKT3 C
ATOM 926 O GLU A 254 12.409 41.336 43.938 1.00 14.28 AKT3 O
ATOM 927 N ILE A 255 14.631 41.609 43.766 1.00 13.31 AKT3 N
ATOM 928 CA ILE A 255 14.944 40.243 44.152 1.00 14.58 AKT3 C
ATOM 929 CB ILE A 255 16.443 39.969 43.980 1.00 15.94 AKT3 C
ATOM 930 CG2 ILE A 255 16.832 38.718 44.746 1.00 15.05 AKT3 C
ATOM 931 CGl ILE A 255 16.782 39.896 42.488 1.00 14.75 AKT3 C
ATOM 932 CDl ILE A 255 18.266 39.906 42.195 1.00 12.61 AKT3 C
ATOM 933 C ILE A 255 14.564 40.044 45.623 1.00 14.68 AKT3 C ATOM 934 O ILE A 255 14.075 38.994 46.018 1.00 14.06 AKT3 O
ATOM 935 N VAL A 256 14.800 41.069 46.428 1.00 15.23 AKT3 N
ATOM 936 CA VAL A 256 14.459 41.001 47.832 1.00 16.54 AI?T3 C
ATOM 937 CB VAL A 256 14.903 42.260 48.576 1.00 17.10 AKT3 C
ATOM 938 CGl VAL A 256 14.289 42.288 49.979 1.00 15.99 AKT3 C
ATOM 939 CG2 VAL A 256 16.412 42.293 48.649 1.00 16.25 AKT3 C
ATOM 940 C VAL A 256 12.959 40.843 47.988 1.00 16.79 AKT3 C
ATOM 941 O VAL A 256 12.504 40.000 48.749 1.00 18.31 AKT3 O
ATOM 942 N SER A 257 12.191 41.653 47.267 1.00 15.89 AKT3 N
ATOM 943 CA SER A 257 10.740 41.574 47.349 1.00 17.01 AKT3 C
ATOM 944 CB SER A 257 10.100 42.503 46.321 1.00 16.73 AKT3 C
ATOM 945 OG SER A 257 8.694 42.344 46.313 1.00 16.51 AKT3 O
ATOM 946 C SER A 257 10.265 40.137 47.117 1.00 17.06 AKT3 C
ATOM 947 O SER A 257 9.452 39.613 47.879 1.00 15.97 AKT3 O
ATOM 948 N ALA A 258 10.791 39.506 46.072 1.00 15.57 AKT3 N
ATOM 949 CA ALA A 258 10.427 38.140 45.738 1.00 16.27 AKT3 C
ATOM 950 CB ALA A 258 11.083 37.735 44.415 1.00 16.12 AKT3 C
ATOM 951 C ALA A 258 10.801 37.148 46.845 1.00 17.11 AKT3 C
ATOM 952 O ALA A 258 9.999 36.284 47.200 1.00 17.58 AKT3 O
ATOM 953 N LEU A 259 12.015 37.271 47.383 1.00 17.14 AKT3 N
ATOM 954 CA LEU A 259 12.476 36.383 48.444 1.00 16.74 AKT3 C
ATOM 955 CB LEU A 259 13.943 36.676 48.798 1.00 15.63 AKT3 C
ATOM 956 CG LEU A 259 14.961 36.322 47.705 1.00 15.43 AKT3 C
ATOM 957 CDl LEU A 259 16.356 36.721 48.126 1.00 16.49 AKT3 C
ATOM 958 CD2 LEU A 259 14.905 34.834 47.414 1.00 13.57 AKT3 C
ATOM 959 C LEU A 259 11.580 36.544 49.664 1.00 17.47 AKT3 C
ATOM 960 O LEU A 259 11.176 35.565 50.282 1.00 18.94 AKT3 O
ATOM 961 N ASP A 260 11.249 37.782 49.999 1.00 17.89 AKT3 N
ATOM 962 CA ASP A 260 10.378 38.023 51.136 1.00 19.91 AKT3 C
ATOM 963 CB ASP A 260 10.113 39.521 51.317 1.00 20.79 AKT3 C
ATOM 964 CG ASP A 260 9.502 39.841 52.670 1.00 21.72 AKT3 C
ATOM 965 ODl ASP A 260 9.865 39.158 53.657 1.00 24.18 AKT3 O
ATOM 966 OD2 ASP A 260 8.680 40.777 52.760 1.00 19.81 AKT3 O
ATOM 967 C ASP A 260 9.069 37.284 50.888 1.00 19.96 AKT3 C
ATOM 968 O ASP A 260 8.537 36.632 51.785 1.00 20.16 AKT3 O
ATOM 969 N TYR A 261 8.558 37.380 49.663 1.00 20.26 AKT3 N
ATOM 970 CA TYR A 261 7.320 36.700 49.313 1.00 20.97 AKT3 C
ATOM 971 CB TYR A 261 7.003 36.889 47.832 1.00 20.87 AKT3 C
ATOM 972 CG TYR A 261 5.962 35.923 47.312 1.00 20.71 AKT3 C
ATOM 973 CDl TYR A 261 4.637 35.995 47.740 1.00 23.45 AKT3 C
ATOM 974 CEl TYR A 261 3.679 35.109 47.272 1.00 23.27 AKT3 C
ATOM 975 CD2 TYR A 261 6.304 34.934 46.401 1.00 20.88 AKT3 C
ATOM 976 CE2 TYR A 261 5.355 34.039 45.921 1.00 22.40 AKT3 C
ATOM 977 CZ TYR A 261 4.044 34.131 46.360 1.00 25.32 AKT3 C
ATOM 978 OH TYR A 261 3.101 33.247 45.886 1.00 26.95 AKT3 O
ATOM 979 C TYR A 261 7.433 35.205 49.604 1.00 21.23 AKT3 C
ATOM 980 O TYR A 261 6.649 34.651 50.376 1.00 21.97 AKT3 O
ATOM 981 N LEU A 262 8.423 34.565 48.985 1.00 20.12 AKT3 N
ATOM 982 CA LEU A 262 8.637 33.136 49.149 1.00 20.64 AKT3 C
ATOM 983 CB LEU A 262 9.796 32.670 48.262 1.00 20.36 AKT3 C
ATOM 984 CG LEU A 262 9.654 32.723 46.734 1.00 20.37 AKT3 C
ATOM 985 CDl LEU A 262 10.887 32.073 46.103 1.00 18.85 AKT3 C
ATOM 986 CD2 LEU A 262 8.402 31.978 46.282 1.00 19.40 AKT3 C
ATOM 987 C LEU A 262 8.889 32.682 50.586 1.00 21.41 AKT3 C
ATOM 988 O LEU A 262 8.374 31.648 51.010 1.00 21.65 AKT3 O
ATOM 989 N HIS A 263 9.683 33.439 51.333 1.00 21.01 AKT3 N
ATOM 990 CA HIS A 263 9.986 33.065 52.709 1.00 21.97 AKT3 C
ATOM 991 CB HIS A 263 11.075 33.975 53.279 1.00 20.70 AKT3 C
ATOM 992 CG HIS A 263 12.415 33.762 52.654 1.00 18.81 AKT3 C
ATOM 993 CD2 HIS A 263 12.829 32.872 51.722 1.00 17.93 AKT3 C
ATOM 994 NDl HIS A 263 13.512 34.538 52.957 1.00 18.98 AKT3 N
ATOM 995 CEl HIS A 263 14.544 34.139 52.235 1.00 17.51 AKT3 C
ATOM 996 NE2 HIS A 263 14.156 33.129 51.478 1.00 18.12 AKT3 N
ATOM 997 C HIS A 263 8.754 33.100 53.598 1.00 22.46 AKT3 C
ATOM 998 O HIS A 263 8.564 32.226 54.442 1.00 23.18 AKT3 O
ATOM 999 N SER A 264 7.921 34.114 53.409 1.00 23.84 AKT3 N
ATOM 1000 CA SER A 264 6.698 34.235 54.183 1.00 24.66 AKT3 C
ATOM 1001 CB SER A 264 5.994 35.552 53.852 1.00 25.47 AKT3 C
ATOM 1002 OG SER A 264 5.723 35.638 52.470 1.00 31.29 AKT3 O
ATOM 1003 C SER A 264 5.819 33.031 53.830 1.00 24.51 AKT3 C
ATOM 1004 O SER A 264 4.958 32.618 54.608 1.00 24.35 AKT3 O
ATOM 1005 N GLY A 265 6.058 32.465 52.650 1.00 24.51 AKT3 N
ATOM 1006 CA GLY A 265 5.322 31.292 52.228 1.00 22.88 AKT3 C ATOM 1007 C GLY A 265 6.047 30.072 52.756 1.00 22.91 AKT3 C
ATOM 1008 O GLY A 265 5.706 28.945 52.441 1.00 20.70 AKT3 O
ATOM 1009 N LYS A 266 7.064 30.314 53.572 1.00 23.80 AKT3 N
ATOM 1010 CA LYS A 266 7.865 29.248 54.159 1.00 25.23 AKT3 C
ATOM 1011 CB LYS A 266 6.989 28.220 54.896 1.00 27.41 AKT3 C
ATOM 1012 CG LYS A 266 5.748 28.757 55.613 1.00 29.56 AKT3 C
ATOM 1013 CD LYS A 266 4.494 28.498 54.766 1.00 31.99 AKT3 C
ATOM 1014 CE LYS A 266 3.186 28.796 55.508 1.00 33.22 AKT3 C
ATOM 1015 NZ LYS A 266 2.958 27.892 56.682 1.00 31.63 AKT3 N
ATOM 1016 C LYS A 266 8.640 28.520 53.071 1.00 25.37 AKT3 C
ATOM 1017 O LYS A 266 8.920 27.335 53.196 1.00 24.61 AKT3 O
ATOM 1018 N ILE A 267 8.980 29.223 51.997 1.00 26.08 AKT3 N
ATOM 1019 CA ILE A 267 9.718 28.594 50.907 1.00 24.44 AKT3 C
ATOM 1020 CB ILE A 267 8.952 28.701 49.571 1.00 24.43 AKT3 C
ATOM 1021 CG2 ILE A 267 9.799 28.132 48.440 1.00 22.51 AKT3 C
ATOM 1022 CGl ILE A 267 7.624 27.947 49.683 1.00 24.95 AKT3 C
ATOM 1023 CDl ILE A 267 6.877 27.797 48.381 1.00 24 ,79 AKT3 C
ATOM 1024 C ILE A 267 11.120 29.152 50.711 1.00 23.91 AKT3 C
ATOM 1025 O ILE A 267 11.336 30.364 50.748 1.00 23.87 AKT3 O
ATOM 1026 N VAL A 268 12.066 28.240 50.502 1.00 23.40 AKT3 N
ATOM 1027 CA VAL A 268 13.467 28.577 50.287 1.00 22.76 AKT3 C
ATOM 1028 CB VAL A 268 14.389 27.706 51.162 1.00 22.52 AKT3 C
ATOM 1029 CGl VAL A 268 15.851 28.152 50.999 1.00 23.51 AKT3 C
ATOM 1030 CG2 VAL A 268 13.959 27.810 52.622 1.00 22.35 AKT3 C
ATOM 1031 C VAL A 268 13.764 28.303 48.827 1.00 22.55 AKT3 C
ATOM 1032 O VAL A 268 13.707 27.156 48.391 1.00 22.98 AKT3 O
ATOM 1033 N TYR A 269 14.086 29.364 48.088 1.00 22.74 AKT3 N
ATOM 1034 CA TYR A 269 14.370 29.289 46.654 1.00 22.54 AKT3 C
ATOM 1035 CB TYR A 269 14.572 30.695 46.078 1.00 22.49 AKT3 C
ATOM 1036 CG TYR A 269 14.447 30.710 44.576 1.00 22.76 AKT3 C
ATOM 1037 CDl TYR A 269 13.228 30.430 43.964 1.00 21.05 AKT3 C
ATOM 1038 CEl TYR A 269 13.121 30.335 42.591 1.00 20.31 AKT3 C
ATOM 1039 CD2 TYR A 269 15.561 30.905 43.764 1.00 22.61 AKT3 C
ATOM 1040 CE2 TYR A 269 15.462 30.808 42.383 1.00 22.79 AKT3 C
ATOM 1041 CZ TYR A 269 14.238 30.519 41.808 1.00 21.64 AKT3 C
ATOM 1042 OH TYR .A 269 14.142 30.383 40.448 1.00 21.20 AKT3 O
ATOM 1043 C TYR A 269 15.560 28.417 46.263 1.00 22.88 AKT3 C
ATOM 1044 O TYR A 269 15.457 27.597 45.350 1.00 21.87 AKT3 O
ATOM 1045 N ARG A 270 16.694 28.627 46.930 1.00 23.67 AKT3 N
ATOM 1046 CA ARG A 270 17.910 27.848 46.681 1.00 24.63 AKT3 C
ATOM 1047 CB ARG A 270 17.616 26.362 46.904 1.00 25.79 AKT3 C
ATOM 1048 CG ARG A 270 16.916 26.083 48.217 1.00 30.56 AKT3 C
ATOM 1049 CD ARG A 270 16.167 24.745 48.200 1.00 34.70 AKT3 C
ATOM 1050 NE ARG A 270 16.983 23.603 48.621 1.00 37.26 AKT3 N
ATOM 1051 CZ ARG A 270 16.505 22.368 48.792 1.00 39.10 AKT3 C
ATOM 1052 NHl ARG A 270 15.216 22.107 48.576 1.00 38.85 AKT3 N
ATOM 1053 NH2 ARG A 270 17.308 21.391 49.196 1.00 39.19 AKT3 N
ATOM 1054 C ARG A 270 18.555 28.021 45.303 1.00 23.93 AKT3 C
ATOM 1055 O ARG A 270 19.747 27.771 45.144 1.00 23.84 AKT3 O
ATOM 1056 N ASP A 271 17.790 28.447 44.305 1.00 23.75 AKT3 N
ATOM 1057 CA ASP A 271 18.366 28.578 42.972 1.00 22.25 AKT3 C
ATOM 1058 CB ASP A 271 17.421 27.972 41.937 1.00 21.63 AKT3 C
ATOM 1059 CG ASP A 271 17.157 26.508 42.195 1.00 21.46 AKT3 C
ATOM 1060 ODl ASP A 271 18.142 25.792 42.453 1.00 22.00 AKT3 O
ATOM 1061 OD2 ASP A 271 15.980 26.078 42.141 1.00 20.13 AKT3 O
ATOM 1062 C ASP A 271 18.750 29.986 42.556 1.00 22.33 AKT3 C
ATOM 1063 O ASP A 271 19.063 30.226 41.394 1.00 22.49 AKT3 O
ATOM 1064 N LEU A 272 18.739 30.916 43.502 1.00 20.97 AKT3 N
ATOM 1065 CA LEU A 272 19.099 32.288 43.181 1.00 21.44 AKT3 C
ATOM 1066 CB LEU A 272 18.827 33.217 44.376 1.00 21.17 AKT3 C
ATOM 1067 CG LEU A 272 19.320 34.673 44.277 1.00 21.37 AKT3 C
ATOM 1068 CDl LEU A 272 18.785 35.320 43.015 1.00 21.50 AKT3 C
ATOM 1069 CD2 LEU A 272 18.879 35.460 45.510 1.00 22.34 AKT3 C
ATOM 1070 C LEU A 272 20.562 32.379 42.757 1.00 21.15 AKT3 C
ATOM 1071 O LEU A 272 21.479 32.144 43.544 1.00 21.32 AKT3 O
ATOM 1072 N LYS A 273 20.759 32.713 41.490 1.00 20.80 AKT3 N
ATOM 1073 CA LYS A 273 22.081 32.857 40.913 1.00 21.75 AKT3 C
ATOM 1074 CB LYS A 273 22.769 31.481 40.802 1.00 22.71 AKT3 C
ATOM 1075 CG LYS A 273 22.078 30.456 39.911 1.00 26.05 AKT3 C
ATOM 1076 CD LYS A 273 22.837 29.132 39.907 1.00 28.35 AKT3 C
ATOM 1077 CE LYS A 273 22.562 28.306 41.173 1.00 32.13 AKT3 C
ATOM 1078 NZ LYS A 273 22.705 29.073 42.454 1.00 32.91 AKT3 N
ATOM 1079 C LYS A 273 21.916 33.530 39.552 1.00 21.33 AKT3 C ATOM 1080 O LYS A 273 20.953 33.274 38.040 1.00 22.55 AKT3 O
ATOM 1081 N LEU A 274 22.849 34.412 39.316 1.00 23.06 AKT3 N
ATOM 1082 CA LEU A 274 22.839 35.182 37.067 1.00 23.40 AKT3 C
ATOM 1083 CB LEU A 274 24.255 35.692 37.690 1.00 23.15 AKT3 C
ATOM 1084 CG LEU A 274 24.498 36.604 36.490 1.00 21.28 AKT3 C
ATOM 1085 CDl LEU A 274 23.856 37.964 36. «586 1.00 19.85 AKT3 C
ATOM 1086 CD2 LEU A 274 25.988 36.747 36.321 1.00 21.96 AKT3 C
ATOM 1087 C LEU A 274 22.275' 34.521 36.698 1.00 23.84 AKT3 C
ATOM 1088 O LEU A 274 21.550 35.160 35.934 .00 24.26 AKT3 O
ATOM 1089 N GIiU A 275 22.625 33.260 35.467 .00 25.71 AKT3 N
ATOM 1090 CA GLU A 275 22.156 32.514 35.301 00 26.45 AKT3 C
ATOM 1091 CB GLU A 275 22.656 31.066 35.362 .00 28.16 AKT3 C
ATOM 1092 CG GLU A 275 24.148 30.887 35.162 .00 30.00 AKT3 C
ATOM 1093 CD GLU A 275 24.956 31.825 36.027 00 33.03 AKT3 C
ATOM 1094 OEl GLU A 275 24.724 31.852 37.261 .00 33.03 AKT3 O
ATOM 1095 OE2 GLU A 275 25.825 32.538 35.472 00 35.47 AKT3 O
ATOM 1096 C GLU A 275 20.631 32.489 35.214 .00 27.68 AKT3 C
ATOM 1097 O GLU A 275 20.061 32.450 34.117 .00 28.83 AKT3 O
ATOM 1098 N ASN A 276 19.981 32.512 36.376 .00 26.52 AKT3 N
ATOM 1099 CA ASN A 276 18.524 32.456 36.461 1.00 25.78 AKT3 C
ATOM 1100 CB ASN A 276 18.127 31.645 37.698 1.00 27.40 AKT3 C
ATOM 1101 CG ASN A 276 18.857 30.311 37.784 1.00 30.28 AKT3 C
ATOM 1102 ODl ASN A 276 18.875 29.671 38.835 1.00 30.88 AKT3 O
ATOM 1103 ND2 ASN A 276 19.463 29.887 36.674 1.00 30.08 AKT3 N
ATOM 1104 C ASN A 276 17.832 33.825 36.502 1.00 25.05 AKT3 C
ATOM 1105 O ASN A 276 16.626 33.910 36.739 1.00 23.32 AKT3 O
ATOM 1106 N LEU A 277 18.590 34.895 36.282 1.00 24.57 AKT3 N
ATOM 1107 CA LEU A 277 18.013 36.232 36.300 1.00 22.94 AKT3 C
ATOM 1108 CB LEU A 277 18.886 37.168 37.130 1.00 21.92 AKT3 C
ATOM 1109 CG LEU A 277 19.014 36.757 38.604 1.00 22.17 AKT3 C
ATOM 1110 CDl LEU A 277 19.867 37.776 39.323 1.00 20.85 AKT3 C
ATOM 1111 CD2 LEU A 277 17.633 36.660 39.264 1.00 21.31 AKT3 C
ATOM 1112 C LEU A 277 17.822 36.787 34.894 1 ,00 22.11 AKT3 C
ATOM 1113 O LEU A 277 18.758 36.868 34.111 1.00 21.42 AKT3 O
ATOM 1114 N MET A 278 16.586 37.161 34.585 1.00 21.92 AKT3 N
ATOM 1115 CA MET A 278 16.258 37.703 33.280 1.00 21.26 AKT3 C
ATOM 1116 CB MET A 278 15.365 36.736 32.512 1.00 24.16 AKT3 C
ATOM 1117 CG MET A 278 15.900 35.328 32.376 1.00 25.57 AKT3 C
ATOM 1118 SD MET A 278 14.708 34.336 31.460 1.00 30.05 AKT3 S
ATOM 1119 CR MET A 278 15.007 35.019 29.739 1.00 27.00 AKT3 C
ATOM 1120 C MET A 278 15.519 39.019 33.404 1.00 20.34 AKT3 C
ATOM 1121 O MET A 278 15.002 39.362 34.471 1.00 19.95 AKT3 O
ATOM 1122 N LEU A 279 15.462 39.746 32.295 1.00 19.72 AKT3 N
ATOM 1123 CA LEU A 279 14.767 41.019 32.254 1.00 19.16 AKT3 C
ATOM 1124 CB LEU A 279 15.655 42.087 31.628 1.00 18.78 AKT3 C
ATOM 1125 CG LEU A 279 16.863 42.511 32.467 1.00 20.24 AKT3 C
ATOM 1126 CDl LEU A 279 17.660 43.577 31.731 1.00 19.84 AKT3 C
ATOM 1127 CD2 LEU A 279 16.387 43.045 33.801 1.00 20.28 AKT3 C
ATOM 1128 C LEU A 279 13.483 40.879 31.449 1.00 19.63 AKT3 C
ATOM 1129 O LEU A 279 13.377 40.035 30.553 1.00 20.94 AKT3 O
ATOM 1130 N ASP A 280 12.492 41.688 31 -788 1.00 20.22 AKT3 N
ATOM 1131 CA ASP A 280 11.243 41.654 31.054 1.00 20.49 AKT3 C
ATOM 1132 CB ASP A 280 10.040 41.668 32.009 1.00 18.44 AKT3 C
ATOM 1133 CG ASP A 280 9.819 43.012 32.670 1.00 19.63 AKT3 C
ATOM 1134 ODl ASP A 280 10.693 43.898 32.557 1.00 17.60 AKT3 O
ATOM 1135 OD2 ASP A 280 8.758 43.174 33.316 1.00 18.71 AKT3 O
ATOM 1136 C ASP A 280 11.258 42.874 30 -139 1.00 21.06 AKT3 C
ATOM 1137 O ASP A 280 12.183 43.691 30.198 1.00 21.17 AKT3 O
ATOM 1138 N LYS A 281 10.245 42.989 29 -293 1.00 21.84 AKT3 N
ATOM 1139 CA LYS A 281 10.158 44.082 28 -341 1.00 21.98 AKT3 C
ATOM 1140 CB LYS A 281 8.748 44.142 27.763 1 ,00 22.49 AKT3 C
ATOM 1141 CG LYS A 281 8.220 42.784 27.342 1.00 26.47 AKT3 C
ATOM 1142 CD LYS A 281 6.723 42.814 27.050 1.00 29.41 AKT3 C
ATOM 1143 CE LYS A 281 5.933 43.273 28.263 1.00 29.67 AKT3 C
ATOM 1144 NZ LYS A 281 6.415 44.591 28 -751 1.00 30.70 AKT3 N
ATOM 1145 C LYS A 281 10.525 45.434 28 -926 1.00 22.46 AKT3 C
ATOM 1146 O LYS A 281 11.186 46.236 28.267 1.00 23.32 AKT3 O
ATOM 1147 N ASP A 282 10.124 45.675 30.168 1.00 22.22 AKT3 N
ATOM 1148 CA ASP A 282 10.381 46.961 30.808 1.00 22.70 AKT3 C
ATOM 1149 CB ASP A 282 9.224 47.303 31-743 1.00 23.89 AKT3 C
ATOM 1150 CG ASP A 282 7.886 47.325 31 ,020 1.00 25.74 AKT3 C
ATOM 1151 ODl ASP A 282 755 48.069 30.018 1.00 24.50 AKT3 O
ATOM 1152 OD2 ASP A 282 6.974 46.590 31.458 1.00 26.80 AKT3 O ATOM 1153 C ASP A 282 11.693 47.125 31.558 1.00 22.81 AKT3 C
ATOM 1154 O ASP A 282 12.053 48.241 31.933 1.00 23.45 AKT3 O
ATOM 1155 N GLY A 283 12.409 46.026 31.770 1.00 21.72 AKT3 N
ATOM 1156 CA GLY A 283 13.669 46.100 32.483 1.00 18.56 AKT3 C
ATOM 1157 C GLY A 283 13.563 45.605 33.912 1.00 18.21 AKT3 C
ATOM 1158 O GLY A 283 14.465 45.819 34.721 1.00 19.26 AKT3 O
ATOM 1159 N HIS A 284 12.460 44.943 34.235 1.00 17.64 AKT3 N
ATOM 1160 CA HIS A 284 12.271 44.417 35.578 1.00 17.26 AKT3 C
ATOM 1161 CB HIS A 284 10.787 44.454 35.960 1.00 16.30 AKT3 C
ATOM 1162 CG HIS A 284 10.264 45.834 36.211 1.00 15.97 AKT3 C
ATOM 1163 CD2 HIS A 284 9.345 46.574 35.547 1.00 14.50 AKT3 C
ATOM 1164 NDl HIS A 284 10.701 46.618 37.257 1.00 17.16 AKT3 N
ATOM 1165 CEl HIS A 284 10.075 47.781 37.228 1.00 15.65 AKT3 C
ATOM 1166 NE2 HIS A 284 9.247 47.779 36.200 1.00 15.52 AKT3 K
ATOM 1167 C HIS A 284 12.812 42.991 35.679 1.00 17.67 AKT3 C
ATOM 1168 O HIS A 284 12.784 42.238 34.704 1.00 18.78 AKT3 O
ATOM 1169 N ILE A 285 13.312 42.646 36.867 1.00 17.98 AKT3 N
ATOM 1170 CA ILE A 285 13.875 41.330 37.154 1.00 17.65 AKT3 C
ATOM 1171 CB ILE A 285 14.513 41.256 38.557 1.00 16.93 AKT3 C
ATOM 1172 CG2 ILE A 285 14.698 39.807 38.950 1.00 18.58 AKT3 C
ATOM 1173 CGl ILE A 285 15.872 41.945 38.574 1.00 16.14 AKT3 C
ATOM 1174 CDl ILE A 285 16.903 41.260 37.708 1.00 16.03 AKT3 C
ATOM 1175 C ILE A 285 12.841 40.220 37.101 1.00 17.97 AKT3 C
ATOM 1176 O ILE A 285 11.681 40.395 37.490 1.00 17.00 AKT3 O
ATOM 1177 N LYS A 286 13.294 39.067 36.628 1.00 18.51 AKT3 N
ATOM 1178 CA LYS A 286 12.454 37.895 36.512 1.00 17.79 AKT3 C
ATOM 1179 CB LYS A 286 11.871 37.794 35.102 1.00 20.35 AKT3 C
ATOM 1180 CG LYS A 286 10.589 38.589 34.937 1.00 23.58 AKT3 C
ATOM 1181 CD LYS A 286 9.528 38.069 35.903 1.00 25.52 AKT3 C
ATOM 1182 CE LYS A 286 8.248 38.886 35.833 1.00 27.52 AKT3 C
ATOM 1183 NZ LYS A 286 7.601 38.830 34.492 1.00 27.21 AKT3 N
ATOM 1184 C LYS A 286 13.271 36.667 36.836 1.00 17.75 AKT3 C
ATOM 1185 O LYS A 286 14.088 36.214 36.030 1.00 15.96 AKT3 O
ATOM 1186 N ILE A 287 13.054 36.157 38.042 1.00 16.47 AKT3 N
ATOM 1187 CA ILE A 287 13.739 34.977 38.518 1.00 16.42 AKT3 C
ATOM 1188 CB ILE A 287 13.614 34.870 40.038 1.00 15.75 AKT3 C
ATOM 1189 CG2 ILE A 287 14.576 33.822 40.575 1.00 15.68 AKT3 C
ATOM 1190 CGl ILE A 287 13.934 36.230 40.658 1.00 18.71 AKT3 C
ATOM 1191 CDl ILE A 287 13.671 36.326 42.140 1.00 18.69 AKT3 C
ATOM 1192 C ILE A 287 13.054 33.802 37.843 1.00 18.04 AKT3 C
ATOM 1193 O ILE A 287 11.863 33.564 38.058 1.00 17.21 AKT3 O
ATOM 1194 N THR A 288 13.820 33.076 37.031 1.00 19.63 AKT3 N
ATOM 1195 CA THR A 288 13.306 31.951 36.267 1.00 23.28 AKT3 C
ATOM 1196 CB THR A 288 13.591 32.153 34.749 1.00 23.62 AKT3 C
ATOM 1197 OGl THR A 288 13.203 33.472 34.346 1.00 24.82 AKT3 O
ATOM 1198 CG2 THR A 288 12.803 31.153 33.933 1.00 24.94 AKT3 C
ATOM 1199 C THR A 288 13.822 30.560 36.658 1.00 24.96 AKT3 C
ATOM 1200 O THR A 288 15.024 30.311 36.629 1.00 26.64 AKT3 O
ATOM 1201 N ASP A 289 12.903 29.657 37.001 1.00 25.91 AKT3 N
ATOM 1202 CA ASP A 289 13.252 28.284 37.365 1.00 27.86 AKT3 C
ATOM 1203 CB ASP A 289 12.012 27.476 37.766 1.00 28.63 AKT3 C
ATOM 1204 CG ASP A 289 11.629 27.664 39.209 1.00 30.72 AKT3 C
ATOM 1205 ODl ASP A 289 12.528 27.645 40.080 1.00 33.18 AKT3 O
ATOM 1206 OD2 ASP A 289 10.420 27.811 39.476 1.00 31.53 AKT3 O
ATOM 1207 C ASP A 289 13.904 27.541 36.205 1.00 29.07 AKT3 C
ATOM 1208 O ASP A 289 13.928 28.020 35.063 1.00 28.61 AKT3 O
ATOM 1209 N PHE A 290 14.388 26.341 36.514 1.00 29.92 AKT3 N
ATOM 1210 CA PHE A 290 15.041 25.479 35.539 1.00 31.63 AKT3 C
ATOM 1211 CB PHE A 290 14.015 24.910 34.554 1.00 31.23 AKT3 C
ATOM 1212 CG PHE A 290 12.703 24.554 35.184 1.00 30.93 AKT3 C
ATOM 1213 CDl PHE A 290 11.644 25.449 35.162 1.00 31.68 AKT3 C
ATOM 1214 CD2 PHE A 290 12.533 23.340 35.828 1.00 31.48 AKT3 C
ATOM 1215 CEl PHE A 290 10.432 25.138 35.774 1.00 31.65 AKT3 C
ATOM 1216 CE2 PHE A 290 11.330 23.023 36.441 1.00 31.51 AKT3 C
ATOM 1217 CZ PHE A 290 10.277 23.928 36.412 1.00 31.36 AKT3 C
ATOM 1218 C PHE A 290 16.095 26.258 34.768 1.00 32.15 AKT3 C
ATOM 1219 O PHE A 290 16.397 25.925 33.624 1.00 30.57 AKT3 O
ATOM 1220 N GLY A 291 16.653 27.288 35.402 1.00 33.82 AKT3 N
ATOM 1221 CA GLY A 291 17.658 28.114 34.744 1.00 36.70 AKT3 C
ATOM 1222 C GLY A 291 18.937 27.394 34.342 1.00 38.06 AKT3 C
ATOM 1223 O GLY A 291 19.880 28.024 33.842 1.00 37.96 AKT3 O
ATOM 1224 N ALA A 292 18.965 26.080 34.575 1.00 39.88 AKT3 N
ATOM 1225 CA ALA A 292 20.112 25.225 34.254 1.00 41.33 AKT3 C ATOM 1226 CB ALA A 292 21.405 26.039 34.237 1.00 41.40 AKT3 C
ATOM 1227 C ALA A 292 20.231 24.098 35.279 1.00 42.51 AKT3 C
ATOM 1228 O ALA A 292 21.335 23.965 35.864 1.00 42.25 AKT3 O
ATOM 1229 OXT ALA A 292 19.226 23.369 35.480 1.00 42.49 AKT3 O
ATOM 1230 C GLY A 308 25.227 23.131 41.563 1.00 56.15 AKT3 C
ATOM 1231 O GLY A 308 25.064 23.306 40.348 1.00 56.55 AKT3 O
ATOM 1232 N GLY A 308 24.940 20.644 41.465 1.00 55.91 AKT3 N
ATOM 1233 CA GLY A 308 24.650 21.902 42.241 1.00 56.11 AKT3 C
ATOM 1234 N THR A 309 25.899 23.982 42.342 1.00 56.05 AKT3 N
ATOM 1235 CA THR A 309 26.526 25.209 41.824 1.00 55.44 AKT3 C
ATOM 1236 CB THR A 309 25.501 26.359 41.733 1.00 56.40 AKT3 C
ATOM 1237 OGl THR A 309 26.142 27.520 41.184 1.00 57.17 AKT3 O
ATOM 1238 CG2 THR A 309 24.915 ' 26.684 43.119 1.00 56.44 AKT3 C
ATOM 1239 C THR A 309 27.682 25.639 42.734 1.00 53.79 AKT3 C
ATOM 1240 O THR A 309 27.558 26.584 43.520 1.00 54.19 AKT3 O
ATOM 1241 N PRO A 310 28.836 24.965 42.605 1.00 52.25 AKT3 N
ATOM 1242 CD PRO A 310 29.167 24.260 41.356 1.00 52.20 AKT3 C
ATOM 1243 CA PRO A 310 30.059 25.200 43.383 1.00 50.79 AKT3 C
ATOM 1244 CB PRO A 310 31.169 24.678 42.459 1.00 50.75 AKT3 C
ATOM 1245 CG PRO A 310 30.566 24.755 41.095 1.00 51.35 AKT3 C
ATOM 1246 C PRO A 310 30.328 26.620 43.873 1.00 49.00 AKT3 C
ATOM 1247 O PRO A 310 30.108 26.934 45.052 1.00 48.04 AKT3 O
ATOM 1248 N GLU A 311 30.815 27.469 42.971 1.00 47.01 AKT3 N
ATOM 1249 CA GLU A 311 31.136 28.848 43.320 1.00 44.69 AKT3 C
ATOM 1250 CB GLU A 311 31.455 29.649 42.051 1.00 45.72 AKT3 C
ATOM 1251 CG GLU A 311 32.363 28.914 41.051 1.00 46.55 AKT3 C
ATOM 1252 CD GLU A 311 31.638 28.584 39.757 1.00 45.93 AKT3 C
ATOM 1253 OEl GLU A 311 30.609 27.875 39.816 1.00 45.33 AKT3 O
ATOM 1254 OE2 GLU A 311 32.092 29.043 38.685 1.00 46.09 AKT3 O
ATOM 1255 C GLU A 311 30.001 29.534 44.082 1.00 42.69 AKT3 C
ATOM 1256 O GLU A 311 30.232 30.498 44.819 1.00 41.32 AKT3 O
ATOM 1257 N TYR A 312 28.782 29.028 43.928 1.00 40.23 AKT3 N
ATOM 1258 CA TYR A 312 27.545 29.653 44.587 1.00 38.88 AKT3 C
ATOM 1259 CB TYR A 312 26.468 29.731 43.611 1.00 40.72 AKT3 C
ATOM 1260 CG TYR A 312 26.756 30.445 42.298 1.00 44.12 AKT3 C
ATOM 1261 CDl TYR A 312 27.789 30.021 41.457 1.00 46.13 AKT3 C
ATOM 1262 CEl TYR A 312 27.984 30.598 40.209 1.00 46.62 AKT3 C
ATOM 1263 CD2 TYR A 312 25.938 31.479 41.854 1.00 45.02 AKT3 C
ATOM 1264 CE2 TYR A 312 26.123 32.066 40.610 1.00 45.74 AKT3 C
ATOM 1265 CZ TYR A 312 27.143 31.619 39.785 1.00 46.78 AKT3 C
ATOM 1266 OH TYR A 312 27.293 32.158 38.516 1.00 46.54 AKT3 O
ATOM 1267 C TYR A 312 27.163 29.024 45.902 1.00 36.62 AKT3 C
ATOM 1268 O TYR A 312 26.387 29.644 46.619 1.00 37.10 AKT3 O
ATOM 1269 N LEU A 313 27.614 27.817 46.226 1.00 33.61 AKT3 N
ATOM 1270 CA LEU A 313 27.170 27.149 47.447 1.00 31.36 AKT3 C
ATOM 1271 CB LEU A 313 27.766 25.746 47.528 1.00 33.59 AKT3 C
ATOM 1272 CG LEU A 313 27.385 24.769 46.410 1.00 34.06 AKT3 C
ATOM 1273 CDl LEU A 313 27.876 23.366 46.761 1.00 33.18 AKT3 C
ATOM 1274 CD2 LEU A 313 25.883 24.773 46.225 1.00 34.39 AKT3 C
ATOM 1275 C LEU A 313 27.456 27.880 48.759 1.00 29.42 AKT3 C
ATOM 1276 O LEU A 313 28.600 28.204 49.078 1.00 28.21 AKT3 O
ATOM 1277 N ALA A 314 26.401 28.118 49.527 1.00 26.96 AKT3 N
ATOM 1278 CA ALA A 314 26.531 28.796 50.808 1.00 25.80 AKT3 C
ATOM 1279 CB ALA A 314 25.144 29.139 51.367 1.00 23.93 AKT3 C
ATOM 1280 C ALA A 314 27.288 27.908 51.791 1.00 25.03 AKT3 C
ATOM 1281 O ALA A 314 27.217 26.681 51.724 1.00 25.05 AKT3 O
ATOM 1282 N PRO A 315 28.038 28.527 52.708 1.00 24.51 AKT3 N
ATOM 1283 CD PRO A 315 28.270 29.979 52.736 1.00 23.77 AKT3 C
ATOM 1284 CA PRO A 315 28.836 27.865 53.738 1.00 25.48 AKT3 C
ATOM 1285 CB PRO A 315 29.141 29.004 54.689 1.00 24.45 AKT3 C
ATOM 1286 CG PRO A 315 29.398 30.112 53.725 1.00 22.86 AKT3 C
ATOM 1287 C PRO A 315 28.168 26.675 54.430 1.00 26.72 AKT3 C
ATOM 1288 O PRO A 315 28.746 25.585 54.480 1.00 27.32 AKT3 O
ATOM 1289 N GLU A 316 26.956 26.873 54.946 1.00 26.48 AKT3 N
ATOM 1290 CA GLU A 316 26.245 25.801 55.640 1.00 26.36 AKT3 C
ATOM 1291 CB GLU A 316 25.003 26.339 56.344 1.00 25.33 AKT3 C
ATOM 1292 CG GLU A 316 23.964 26.908 55.411 1.00 23.24 AKT3 C
ATOM 1293 CD GLU A 316 24.129 28.392 55.196 1.00 22.14 AKT3 C
ATOM 1294 OEl GLU A 316 25.259 28.846 54.924 1.00 20.36 AKT3 O
ATOM 1295 OE2 GLU A 316 23.115 29.101 55.299 1.00 22.74 AKT3 O
ATOM 1296 C GLU A 316 25.833 24.640 54.743 1.00 28.02 AKT3 C
ATOM 1297 O GLU A 316 25.844 23.496 55.179 1.00 28.51 AKT3 O
ATOM 1298 N VAL A 317 25.445 24.914 53.505 1.00 29.09 AKT3 N ATOM 1299 CA VAL A 317 25.067 23.820 52.625 1.00 31.10 AKT3 C
ATOM 1300 CB VAL A 317 24.523 24.327 51.278 1.00 30.91 AKT3 C
ATOM 1301 CGl VAL A 317 24.422 23.176 50.301 1.00 30.98 AKT3 C
ATOM 1302 CG2 VAL A 317 23.145 24.932 51.477 1.00 32.26 AKT3 C
ATOM 1303 C VAL A 317 26.303 22.953 52.397 1.00 32.88 AKT3 C
ATOM 1304 O VAL A 317 26.230 21.726 52.471 1.00 32.52 AKT3 O
ATOM 1305 N LEU A 318 27.440 23.592 52.133 1.00 35.60 AKT3 N
ATOM 1305 CA LEU A 318 28.690 22.860 51.943 1.00 37.68 AKT3 C
ATOM 1307 CB LEU A 318 29.880 23.816 51.784 1.00 37.71 AKT3 C
ATOM 1308 CG LEU A 318 30.058 24.464 50.411 1.00 39.00 AKT3 C
ATOM 1309 CDl LEU A 318 31.341 25.292 50.374 1.00 37.47 AKT3 C
ATOM 1310 CD2 LEU A 318 30.099 23.369 49.361 1.00 38.95 AKT3 C
ATOM 1311 C LEU A 318 28.927 22.001 53.175 1.00 38.56 AKT3 C
ATOM 1312 O LEU A 318 29.251 20.819 53.082 1.00 38.62 AKT3 O
ATOM 1313 N GLU A 319 28.784 22.611 54.342 1.00 40.35 AKT3 N
ATOM 1314 CA GLU A 319 28.984 21.864 55.556 1.00 42.41 AKT3 C
ATOM 1315 CB GLU A 319 28.952 22.792 56.766 1.00 41.78 AKT3 C
ATOM 1316 CG GLU A 319 30.156 23.714 56.871 1.00 41.50 AKT3 C
ATOM 1317 CD GLU A 319 30.014 24.709 58.011 1.00 42.58 AKT3 C
ATOM 1318 OEl GLU A 319 30.907 25.578 58.170 1.00 42.71 AKT3 O
ATOM 1319 OE2 GLU A 319 29.002 24.624 58.748 1.00 42.65 AKT3 O
ATOM 1320 C GLU A 319 27.880 20.820 55.635 1.00 44.61 AKT3 C
ATOM 1321 O GLU A 319 26.841 20.930 54.972 1.00 44.71 AKT3 O
ATOM 1322 N ASP A 320 28.120 19.792 56.430 1.00 46.35 AKT3 N
ATOM 1323 CA ASP A 320 27.152 18.731 56.583 1.00 48.98 AKT3 C
ATOM 1324 CB ASP A 320 27.888 17.395 56.773 1.00 48.38 AKT3 C
ATOM 1325 CG ASP A 320 28.567 16.918 55.490 1.00 47.04 AKT3 C
ATOM 1326 ODl ASP A 320 27.829 16.553 54.545 1.00 46.52 AKT3 O
ATOM 1327 OD2 ASP A 320 29.824 16.918 55.423 1.00 45.18 AKT3 O
ATOM 1328 C ASP A 320 26.240 19.044 57.766 1.00 50.95 AKT3 C
ATOM 1329 O ASP A 320 ■ 25.859 18.143 58.537 1.00 52.05 AKT3 O
ATOM 1330 N ASN A 321 25.893 20.327 57.896 1.00 51.48 AKT3 N
ATOM 1331 CA ASN A 321 25.014 20.798 58.972 1.00 52.79 AKT3 C
ATOM 1332 CB ASN A 321 25.389 22.250 59.371 1.00 53.40 AKT3 C
ATOM 1333 CG ASN A 321 24.726 22.711 60.693 1.00 53.57 AKT3 C
ATOM 1334 ODl ASN A 321 23.496 22.673 60.842 1.00 52.65 AKT3 O
ATOM 1335 ND2 ASN A 321 25.551 23.155 61.649 1.00 53.64 AKT3 N
ATOM 1336 C ASN A 321 23.577 20.751 58.438 1.00 53.13 AKT3 C
ATOM 1337 O ASN A 321 23.193 19.796 57.743 1.00 53.66 AKT3 O
ATOM 1338 N ASP A 322 22.797 21.785 58.769 1.00 52.91 AKT3 N
ATOM 1339 CA ASP A 322 21.404 21.939 58.331 1.00 51.95 AKT3 C
ATOM 1340 CB ASP A 322 20.483 22.215 59.553 1.00 52.87 AKT3 C
ATOM 1341 CG ASP A 322 19.802 20.941 60.103 1.00 54.11 AKT3 C
ATOM 1342 ODl ASP A 322 20.515 20.026 60.595 1.00 54.49 AKT3 O
ATOM 1343 OD2 ASP A 322 18.545 20.859 60.045 1.00 53.58 AKT3 O
ATOM 1344 C ASP A 322 21.365 23.150 57.362 1.00 50.30 AKT3 C
ATOM 1345 O ASP A 322 22.023 23.143 56.308 1.00 49.80 AKT3 O
ATOM 1346 N TYR A 323 20.591 24.170 57.742 1.00 47.46 AKT3 N
ATOM 1347 CA TYR A 323 20.440 25.414 56.995 1.00 45.52 AKT3 C
ATOM 1348 CB TYR A 323 21.169 25.334 55.639 1.00 46.38 AKT3 C
ATOM 1349 CG TYR A 323 20.422 24.617 54.545 1.00 46.68 AKT3 C
ATOM 1350 CDl TYR A 323 19.268 25.163 54.000 1.00 47.89 AKT3 C
ATOM 1351 CEl TYR A 323 18.572 24.525 53.006 1.00 48.21 AKT3 C
ATOM 1352 CD2 TYR ,A 323 20.867 23.398 54.056 1.00 47.21 AKT3 C
ATOM 1353 CE2 TYR A 323 20.177 22.744 53.060 1.00 48.89 AKT3 C
ATOM 1354 CZ TYR A 323 19.025 23.314 52.540 1.00 48.78 AKT3 C
ATOM 1355 OH TYR A 323 18.302 22.666 51.563 1.00 50.65 AKT3 O
ATOM 1356 C TYR A 323 18.963 25.817 56.812 1.00 43.57 AKT3 C
ATOM 1357 O TYR A 323 18.089 25.391 57.591 1.00 44.03 AKT3 O
ATOM 1358 N GLY A 324 18.699 26.668 55.817 1.00 39.32 AKT3 N
ATOM 1359 CA GLY A 324 17.348 27.120 55.552 1.00 33.73 AKT3 C
ATOM 1360 C GLY 'A 324 17.307 28.395 54.727 1.00 30.38 AKT3 C
ATOM 1361 O GLY A 324 18.230 28.682 53.958 1.00 28.55 AKT3 O
ATOM 1362 N ARG A 325 16.235 29.165 54.908 1.00 27.02 AKT3 N
ATOM 1363 CA ARG A 325 16.012 30.410 54.181 1.00 24.11 AKT3 C
ATOM 1364 CB ARG A 325 14.829 31.167 54.792 1.00 24.08 AKT3 C
ATOM 1365 CG ARG A 325 15.002 31.557 56.241 1.00 23.31 AKT3 C
ATOM 1366 CD ARG A 325 13.842 32.408 56.714 1.00 22.76 AKT3 C
ATOM 1367 NE ARG A 325 13.950 32.724 58.129 1.00 23.22 AKT3 N
ATOM" 1368 CZ ARG A 325 14.851 33.550 58.651 1.00 25.78 AKT3 C
ATOM 1369 NHl ARG A 325 15.736 34.164 57.872 1.00 26.98 AKT3 N
ATOM 1370 NH2 ARG A 325 14.880 33.751 59.961 1.00 25.90 AKT3 N
ATOM 1371 C ARG A 325 17.202 31.355 54.044 1.00 22.78 AKT3 C ATOM 1372 O ARG A 325 17.218 32.210 53.163 00 21.89 AKT3 O
ATOM 1373 N ALA A 326 18.198 31.200 54.905 00 22.30 AKT3 N
ATOM 1374 CA ALA A 326 19.382 32.049 54.858 00 20.37 AKT3 C
ATOM 1375 CB ALA A 326 20.203 31.870 56.129 00 18.99 AKT3 C
ATOM 1376 C ALA A 326 20.258 31.792 53.629 00 20.12 AKT3 C
ATOM 1377 O ALA A 326 21.123 32.611 53.318 00 21.02 AKT3 O
ATOM 1378 N VAL A 327 20.057 30.672 52.934 00 17.79 AKT3 N
ATOM 1379 CA VAL A 327 20.865 30.407 51.744 00 19.25 AKT3 C
ATOM 1380 CB VAL A 327 20.672 28.963 51.170 1.00 21.29 AKT3 C
ATOM 1381 CGl VAL A 327 20.831 27.914 52.271 1.00 22.16 AKT3 C
ATOM 1382 CG2 VAL A 327 19.318 28.852 50.478 .00 20.85 AKT3 C
ATOM 1383 C VAL A 327 20.476 31.394 50.640 .00 19.27 AKT3 C
ATOM 1384 O VAL A 327 21.289 31.720 49.770 .00 20.42 AKT3 O
ATOM 1385 N ASP A 328 19.232 31.869 50.678 .00 17.36 AKT3 N
ATOM 1386 CA ASP A 328 18.753 32.814 49.676 .00 17.43 AKT3 C
ATOM 1387 CB ASP A 328 17.227 32.925 49.703 .00 17.20 AKT3 C
ATOM 1388 CG ASP A 328 16.539 31.652 49.247 .00 19.14 AKT3 C
ATOM 1389 ODl ASP A 328 17.114 30.928 48.397 .00 19.76 AKT3 O
ATOM 1390 OD2 ASP A 328 15.417 31.381 49.729 .00 19.25 AKT3 O
ATOM 1391 C ASP A 328 19.357 34.202 49.828 .00 18.30 AKT3 C
ATOM 1392 O ASP A 328 19.460 34.953 48.858 1.00 18.98 AKT3 O
ATOM 1393 N TRP A 329 19.750 34.549 51.045 1.00 17.15 AKT3 N
ATOM 1394 CA TRP A 329 20.359 35.843 51.279 1.00 15.77 AKT3 C
ATOM 1395 CB TRP A 329 20.197 36.222 52.745 1.00 17.49 AKT3 C
ATOM 1396 CG TRP A 329 18.753 36.352 53.133 1.00 20.07 AKT3 C
ATOM 1397 CD2 TRP A 329 17.727 37.049 52.407 1.00 21.50 AKT3 C
ATOM 1398 CE2 TRP A 329 16.529 36.905 53.137 1.00 21.42 AKT3 C
ATOM 1399 CE3 TRP A 329 17.707 37.781 51.211 1.00 20.85 AKT3 C
ATOM 1400 CDl TRP A 329 18.150 35.831 54.240 1.00 18.89 AKT3 C
ATOM 1401 NEl TRP A 329 16.815 36.159 54.250 1.00 20.01 AKT3 N
ATOM 1402 CZ2 TRP A 329 15.320 37.466 52.709 .00 21.87 AKT3 C
ATOM 1403 CZ3 TRP A 329 16.510 38.337 50.788 00 19.68 AKT3 C
ATOM 1404 CH2 TRP A 329 15.332 38.177 51.535 .00 20.77 AK.T3 C
ATOM 1405 C TRP A 329 21.834 35.763 50.880 .00 15.78 AKT3 C
ATOM 1406 O TRP A 329 22.429 36.754 50.482 .00 15.61 AKT3 O
ATOM 1407 N TRP A 330 22.415 34.573 50.991 .00 14.71 AKT3 N
ATOM 1408 CA TRP A 330 23.805 34.353 50.599 1.00 13.96 AKT3 C
ATOM 1409 CB TRP A 330 24.266 32.966 51.086 1.00 14.23 AKT3
ATOM 1410 CG TRP A 330 25.521 32.462 50.456 1.00 13.87 AKT3
ATOM 1411 CD2 TRP A 330 26.855 32.625 50.952 1.00 15.07 AKT3
ATOM 1412 CE2 TRP A 330 27.727 32.053 50.002 1.00 15.85 AKT3
ATOM 1413 CE3 TRP A 330 27.398 33.206 52.103 1.00 13.77 AKT3
ATOM 1414 CDl TRP A 330 25.634 31.809 49.261 1.00 14.63 AKT3 C
ATOM 1415 NEl TRP A 330 26.957 31.563 48.980 OO 16.25 AKT3 N
ATOM 1416 CZ2 TRP A 330 29.112 32.045 50.170 00 16.14 AKT3 C
ATOM 1417 CZ3 TRP A 330 28.768 33.197 52.265 00 14.86 AKT3 C
ATOM 1418 CH2 TRP A 330 29.611 32.621 51.304 00 14.48 AKT3 C
ATOM 1419 C TRP A 330 23.842 34.450 49.065 OO 13.42 AKT3 C
ATOM 1420 O TRP A 330 24.789 34.978 48.474 00 11.72 AKT3 O
ATOM 1421 N GLY A 331 22.781 33.944 48.441 00 12.01 AKT3 N
ATOM 1422 CA GLY A 331 22.660 34.003 47.000 00 12.76 AKT3 C
ATOM 1423 C GLY A 331 22.556 35.454 46.574 00 13.05 AKT3 C
ATOM 1424 O GLY A 331 23.200 35.868 45.610 00 14.33 AKT3 O vATOM 1425 N LEU A 332 21.747 36.231 47.295 00 12.26 AKT3 N
ATOM 1426 CA LEU A 332 21.590 37.648 46.990 00 12.63 AKT3 C
ATOM 1427 CB LEU A 332 20.665 38.335 48.008 00 11.08 AKT3 C
ATOM 1428 CG LEU A 332 20.405 39.829 47.754 00 10.85 AKT3 C
ATOM 1429 CDl LEU A 332 19.763 39.995 46.394 00 10.27 AKT3 C
ATOM 1430 CD2 LEU A 332 19.510 40.413 48.823 00 9.10 AKT3 C
ATOM 1431 C LEU A 332 22.970 38.297 47.036 00 12.92 AKT3 C
ATOM 1432 O LEU A 332 23.349 39.064 46.152 00 12.54 AKT3 O
ATOM 1433 N GLY A 333 23.725 37.964 48.074 00 13.84 AKT3 N
ATOM 1434 CA GLY A 333 25.056 38.516 48.222 00 14.70 AKT3 C
ATOM 1435 C GLY A 333 25.962 38.157 47.062 00 14.77 AKT3 C
ATOM 1436 O GLY A 333 26.693 38.998 46.548 1.00 12.55 AKT3 O
ATOM 1437 N VAL A 334 25.911 36.904 46.636 1.00 14.08 AKT3 N
ATOM 1438 CA VAL A 334 26.761 36.496 45.540 1.00 15.50 AKT3 C
ATOM 1439 CB VAL A 334 26.634 34.997 45.273 1.00 15.89 AKT3 C
ATOM 1440 CGl VAL A 334 27.515 34.589 44.186 1.00 13.37 AKT3 C
ATOM 1441 CG2 VAL A 334 26.879 34.224 46.562 1.00 12.58 AKT3 C
ATOM 1442 C VAL A 334 26.457 37.285 44.265 1.00 15.65 AKT3 C
ATOM 1443 O VAL A 334 27.357 37.904 43.704 1.00 15.85 AKT3 O
ATOM 1444 N VAL A 335 25.200 37.282 43.820 1.00 15.12 AKT3 N ATOM 1445 CA VAL A 335 24.825 38.014 42.609 15.69 AKT3 C
ATOM 1446 CB VAL A 335 23.338 37.775 42.212 15.17 AKT3 C
ATOM 1447 CGl VAL A 335 23.057 36.299 42.109 15.86 AKT3 C
ATOM 1448 CG2 VAL A 335 22.409 38.415 43.216 19.41 AKT3 C
ATOM 1449 C VAL A 335 25.064 39.533 42.676 15.55 AKT3 C
ATOM 1450 O VAL A 335 25.595 40.111 41.735 16.84 AKT3 O
ATOM 1451 N MET A 336 24.683 40.179 43.775 14.90 AKT3 N
ATOM 1452 CA MET A 336 24.884 41.620 43.893 14.19 AKT3 C
ATOM 1453 CB MET A 336 24.265 42.150 45.189 12.55 AKT3 C
ATOM 1454 CG MET A 336 22.750 42.115 45.203 13.23 AKT3 C
ATOM 1455 SD MET A 336 22.007 42.890 46.651 1.00 14.34 AKT3 S
ATOM 1456 CE MET A 336 22.315 44.622 46.277 00 15.52 AKT3 C
ATOM 1457 C MET A 336 26.369 41.953 43.849 00 15.28 AKT3 C
ATOM 1458 O MET A 336 26.767 43.026 43.389 00 14.96 AKT3 O
ATOM 1459 N TYR A 337 27.185 41.024 44.338 00 17.12 AKT3 N
ATOM 1460 CA TYR A 337 28.624 41.203 44.336 00 18.86 AKT3 C
ATOM 1461 CB TYR A 337 29.302 40.107 45.173 00 20.94 AKT3 C
ATOM 1462 CG TYR A 337 30.820 40.193 45.185 1.00 23.67 AKT3 C
ATOM 1463 CDl TYR A 337 31.565 39.786 44.089 1.00 22.54 AKT3 C
ATOM 1464 CEl TYR A 337 32.945 39.908 44.073 1.00 24.13 AKT3 C
ATOM 1465 CD2 TYR A 337 31.503 40.727 46.282 1.00 24.52 AKT3 C
ATOM 1466 CE2 TYR A 337 32.888 40.855 46.274 1.00 24.33 AKT3 C
ATOM 1467 CZ TYR A 337 33.601 40.443 45.162 .00 24.66 AKT3 C
ATOM 1468 OH TYR A 337 34.969 40.571 45.129 .00 24.13 AKT3 O
ATOM 1469 C TYR A 337 29.112 41.156 42.894 .00 18.31 AKT3 C
ATOM 1470 O TYR A 337 29.880 42.007 42.467 .00 17.93 AKT3 O
ATOM 1471 N GLU A 338 28.643 40.167 42.143 .00 18.49 AKT3 N
ATOM 1472 CA GLU A 338 29.035 40.021 40.746 .00 20.01 AKT3 C
ATOM 1473 CB GLU A 338 28.449 38.735 40.160 .00 21.85 AKT3 C
ATOM 1474 CG GLU A 338 28.983 37.453 40.767 1.00 25.86 AKT3 C
ATOM 1475 CD GLU A 338 28.196 36.246 40.303 .00 28.98 AKT3 C
ATOM 1476 OEl GLU A 338 26.970 36.224 40.541 .00 30.69 AKT3 O
ATOM 1477 OE2 GLU A 338 28.786 35.327 39.697 .00 31.99 AKT3 O
ATOM 1478 C GLU A 338 28.592 41.202 39.885 .00 18.46 AKT3 C
ATOM 1479 O GLU A 338 29.156 41.446 38.821 .00 17.34 AKT3 O
ATOM 1480 N MET A 339 27.579 41.924 40.348 1.00 17.74 AKT3 N
ATOM 1481 CA MET A 339 27.056 43.070 39.616 1.00 19.16 AKT3 C
ATOM 1482 CB MET A 339 25.575 43.280 39.957 00 18.24 AKT3 C
ATOM 1483 CG MET A 339 24.685 42.085 39.679 00 19:72 AKT3 C
ATOM 1484 SD MET A 339 22.944 42.435 40.008 00 21.47 AKT3 S
ATOM 1485 CE MET A 339 22.278 42.458 38.387 00 25.62 AKT3 C
ATOM 1486 C MET A 339 27.826 44.369 39.878 00 19.49 AKT3 C
ATOM 1487 O MET A 339 28.128 45.116 38.954 00 19.43 AKT3 O
ATOM 1488 N MET A 340 28.134 44.641 41.138 00 20.47 AKT3 N
ATOM 1489 CA MET A 340 28.855 45.862 41.478 00 22.08 AKT3 C
ATOM 1490 CB MET A 340 28.621 46.254 42.938 00 21.96 AKT3 C
ATOM 1491 CG MET A 340 27.255 46.827 43.247 00 19.73 AKT3 C
ATOM 1492 SD MET A 340 27.113 47.220 45.016 00 21.49 AKT3 S
ATOM 1493 CE MET A 340 26.110 45.889 45.614 00 17.06 AKT3 C
ATOM 1494 C MET A 340 30.340 45.714 41.261 00 22.60 AKT3 C
ATOM 1495 O MET A 340 30.999 46.659 40.854 00 25.00 AKT3 O
ATOM 1496 N CYS A 341 30.865 44.525 41.526 00 22.83 AKT3 N
ATOM 1497 CA CYS A 341 32.294 44.277 41.379 00 23.03 AKT3 C
ATOM 1498 CB CYS A 341 32.771 43.324 42.477 00 19.67 AKT3 C
ATOM 1499 SG CYS A 341 32.458 43.954 44.124 00 20.32 AKT3 S
ATOM 1500 C CYS A 341 32.724 43.733 40.026 00 24.09 AKT3 C
ATOM 1501 O CYS A 341 33.878 43.904 39.627 00 25.27 AKT3 O
ATOM 1502 N GLY A 342 31.818 43.063 39.327 00 25.62 AKT3 N
ATOM 1503 CA GLY A 342 32.177 42.521 38.026 00 27.64 AKT3 C
ATOM 1504 C GLY A 342 32.882 41.170 38.047 00 29.06 AKT3 C
ATOM 1505 O GLY A 342 33.352 40.692 37.017 1.00 29.93 AKT3 O
ATOM 1506 N ARG A 343 32.968 40.548 39.215 1.00 31.24 AKT3 N
ATOM 1507 CA ARG A 343 33.605 39.239 39.322 1.00 33.33 AKT3 C
ATOM 1508 CB ARG A 343 35.099 39.379 39.639 36.15 AKT3 C
ATOM 1509 CG ARG A 343 35.413 39.739 41.088 40.35 AKT3 C
ATOM 1510 CD ARG A 343 36.905 39.559 41.383 43.02 AKT3 C
ATOM 1511 NE ARG A 343 37.717 40.411 40.518 47.56 AKT3 N
ATOM 1512 CZ ARG A 343 39.042 40.319 40.380 49.52 AKT3 C
ATOM 1513 NHl ARG A 343 39.736 39.398 41.051 50.02 AKT3 N
ATOM 1514 NH2 ARG A 343 39.681 41.160 39.573 50.19 AKT3 N
ATOM 1515 C ARG A 343 32.933 38.416 40.415 32.77 AKT3 C
ATOM 1516 O ARG A 343 32.067 38.914 41.135 30.12 AKT3 O
ATOM 1517 N LEU A 344 33.344 37.155 40.520 1.00 33.39 AKT3 N ATOM 1518 CA LEU A 344 32.812 36.234 41.521 1.00 34.31 AKT3 C ATOM 1519 CB LEU A 344 33.138 34.790 41.129 1.00 35.83 AKT3 C ATOM 1520 CG LEU A 344 32.299 33.632 41.684 1.00 37.63 AKT3 C ATOM 1521 CDl LEU A 344 31.031 33.457 40.836 00 36.37 AKT3 C ATOM 1522 CD2 LEU A 344 33.136 32.338 41.672 00 37.98 AKT3 C ATOM 1523 C LEU A 344 33.509 36.575 42.831 00 34.21 AKT3 C ATOM 1524 O LEU A 344 34.640 37.046 42.831 00 34.82 AKT3 O ATOM 1525 N PRO A 345 32.846 36.347 43.966 ,00 34.85 AKT3 N ATOM 1526 CD PRO A 345 31.466 35.860 44.147 00 34.77 AKT3 C ATOM 1527 CA PRO A 345 33.476 36.661 45.252 ,00 36.41 AKT3 C ATOM 1528 CB PRO A 345 32.290 36.688 46.209 ,00 35.31 AKT3 C ATOM 1529 CG PRO A 345 31.399 35.610 45.641 ,00 35.21 AKT3 C ATOM 1530 C PRO A 345 34.551 35.648 45.674 .00 38.41 AKT3 C ATOM 1531 O PRO A 345 35.588 36.025 46.234 ,00 38.00 AKT3 O ATOM 1532 N PHE A 346 34.296 34.370 45.396 .00 40.12 AKT3 N ATOM 1533 CA PHE A 346 35.216 33.292 45.752 1.00 41.87 AKT3 C ATOM 1534 CB PHE A 346 34.636 32.433 46.877 00 41.47 AKT3 C ATOM 1535 CG PHE A 346 34.194 33.218 48.072 00 42.97 AKT3 C ATOM 1536 CDl PHE A 346 35.108 33.982 48.799 00 43.32 AKT3 C ATOM 1537 CD2 PHE A 346 321862 33.225 48.456 00 41.90 AKT3 C ATOM 1538 CEl PHE A 346 34.695 34.741 49.885 00 43.18 AKT3 C ATOM 1539 CE2 PHE A 346 32.443 33.982 49.540 00 42.81 AKT3 C ATOM 1540 CZ PHE A 346 33.359 34.743 50.255 00 42.37 AKT3 C ATOM 1541 C PHE A 346 35.441 32.408 44.546 00 43.71 AKT3 C ATOM 1542 O PHE A 346 34.487 31.957 43.902 00 44.39 AKT3 O ATOM 1543 N TYR A 347 36.698 32.154 44.227 00 45.75 AKT3 N ATOM 1544 CA TYR A 347 36.968 31.298 43.091 ,00 48.06 AKT3 C ATOM 1545 CB TYR A 347 36.669 32.036 41.789 00 48.74 AKT3 C ATOM 1546 CG TYR A 347 37.061 31.233 40.574 .00 49.95 AKT3 C ATOM 1547 CDl TYR A 347 36.449 30.011 40.294 00 50.70 AKT3 C ATOM 1548 CEl TYR A 347 36.861 29.236 39.216 .00 50.92 AKT3 C ATOM 1549 CD2 TYR A 347 38.091 31.659 39.741 ,00 49.84 AKT3 C ATOM 1550 CE2 TYR A 347 38.506 30.891 38.672 ,00 50.39 AKT3 C ATOM 1551 CZ TYR A 347 37.891 29.682 38.414 ,00 50.44 AKT3 C ATOM 1552 OH TYR A 347 38.328 28.916 37.355 ,00 51.26 AKT3 O ATOM 1553 C TYR A 347 38.366 30.701 43.016 ,00 49.28 AKT3 C ATOM 1554 O TYR A 347 39.372 31.328 43.385 ,00 48.85 AKT3 O ATOM 1555 N ASN A 348 38.407 29.463 42.536 ,00 50.76 AKT3 N ATOM 1556 CA ASN A 348 39.657 28.745 42.361 ,00 51.94 AKT3 C ATOM 1557 CB ASN A 348 40.214 28.210 43.682 .00 52.15 AKT3 C ATOM 1558 CG ASN A 348 41.391 27.260 43.460 ,00 53.52 AKT3 C ATOM 1559 ODl ASN A 348 41.656 26.366 44.271 1.00 53.92 AKT3 O ATOM 1560 ND2 ASN A 348 42.106 27.454 42.345 00 53.50 AKT3 N ATOM 1561 C ASN A 348 39.457 27.574 41.425 00 52.12 AKT3 C ATOM 1562 O ASN A 348 38.416 26.906 41.441 00 51.77 AKT3 O ATOM 1563 N GLN A 349 40.484 27.338 40.620 00 53.20 AKT3 N ATOM 1564 CA GLN A 349 40.501 26.256 39.654 00 54.18 AKT3 C ATOM 1565 CB GLN A 349 41.875 26.221 38.995 1.00 54.97 AKT3 C ATOM 1566 CG GLN A 349 42.294 27.605 38.508 1.00 56.03 AKT3 C ATOM 1567 CD GLN A 349 43.725 27.647 37.990 1.00 57.31 AKT3 C ATOM 1568 OEl GLN A 349 44.084 26.913 37.055 .00 56.83 AKT3 O ATOM 1569 NE2 GLN A 349 44.552 28.511 38.596 .00 56.81 AKT3 N ATOM 1570 C GLN A 349 40.179 24.932 40.343 .00 53.89 AKT3 C ATOM 1571 0 GLN A 349 39.410 24.122 39.813 .00 53.00 AKT3 O ATOM 1572 N ASP A 350 40.755 24.703 41.522 .00 53.62 AKT3 N ATOM 1573 CA ASP A 350 40.441 23.460 42.226 .00 54.15 AKT3 C ATOM 1574 CB ASP A 350 41.535 23.048 43.215 .00 54.15 AKT3 C ATOM 1575 CG ASP A 350 41.135 21.818 44.014 .00 54.52 AKT3 C ATOM 1576 ODl ASP A 350 42.002 21.215 44.704 .00 53.85 AKT3 O ATOM 1577 OD2 ASP A 350 39.931 21.456 43.938 .00 54.10 AKT3 O ATOM 1578 C ASP A 350 39.133 23.642 42.985 .00 53.76 AKT3 C ATOM 1579 O ASP A 350 39.102 24.213 44.080 .00 53.08 AKT3 O ATOM 1580 N HIS A 351 38.052 23.151 42.398 .00 54.49 AKT3 N ATOM 1581 CA HIS A 351 36.746 23.282 43.027 .00 55.32 AKT3 C ATOM 1582 CB HIS A 351 35.659 22.706 42.105 .00 56.13 AKT3 C ATOM 1583 CG HIS A 351 35.437 23.521 40.865 .00 56.92 AKT3 C ATOM 1584 CD2 HIS A 351 35.996 24.688 40.454 .00 57.42 AKT3 C ATOM 1585 NDl HIS A 351 34.538 23.161 39.882 .00 57.43 AKT3 N ATOM 1586 CEl HIS A 351 34.550 24.069 38.920 .00 57.68 AKT3 C ATOM 1587 NE2 HIS A 351 35.425 25.007 39.242 .00 57.95 AKT3 N ATOM 1588 C HIS A 351 36.676 22.668 44.424 .00 55.05 AKT3 C ATOM 1589 O HIS A 351 35.585 22.386 44.929 1.00 56.32 AKT3 O ATOM 1590 N GLU A 352 37.844 22.461 45.040 1.00 53.84 AKT3 N ATOM 1591 CA GLU A 352 37.925 21.938 46.404 51.22 AKT3 C
ATOM 1S92 CB GLU A 352 38.681 20.615 46.474 52.15 AKT3 C
ATOM 1593 CG GLU A 352 38.731 20.069 47.906 53.70 AKT3 C
ATOM 1594 CD GLU A 352 39.510 18.766 48.041 54.27 AKT3 C
ATOM 1595 OEl GLU A 352 40.753 18.782 47.863 54.22 AKT3 O
ATOM 1596 OE2 GLU A 352 38.873 17.725 48.331 54.67 AKT3 O
ATOM 1597 C GLU A 352 38.665 22.974 47.241 49.29 AKT3 C
ATOM 1598 O GLU A 352 38.464 23.070 48.461 49.03 AKT3 O
ATOM 1599 N LYS A 353 39.551 23.729 46.597 46.72 AKT3 N
ATOM 1600 CA LYS A 353 40.250 24.779 47.314 44.77 AKT3 C
ATOM 1601 CB LYS A 353 41.414 25.346 46.500 44.57 AKT3 C
ATOM 1602 CG LYS A 353 42.521 24.358 46.129 45.35 AKT3 C
ATOM 1603 CD LYS A 353 43.612 25.074 45.310 44.63 AKT3 C
ATOM 1604 CE LYS A 353 44.706 24.131 44.797 44.22 AKT3 C
ATOM 1605 NZ LYS A 353 45.579 23.578 45.886 43.89 AKT3 N
ATOM 1606 C LYS A 353 39.159 25.833 47.418 1.00 43.55 AKT3 C
ATOM 1607 O LYS A 353 38.966 26.467 48.460 42.88 AKT3 O
ATOM 1608 N LEU A 354 38.435 25.994 46.312 42.20 AKT3 N
ATOM 1609 CA LEU A 354 37.347 26.954 46.240 40.71 AKT3 C
ATOM 1610 CB LEU A 354 36.477 26.669 45.013 39.91 AKT3 C
ATOM 1611 CG LEU A 354 35.246 27.544 44.729 40.09 AKT3 C
ATOM 1612 CDl LEU A 354 35.582 29.022 44.873 38.66 AKT3 C
ATOM 1613 CD2 LEU A 354 34.754 27.254 43.319 39.24 AKT3 C
ATOM 1614 C LEU A 354 36.523 26.846 47.513 40.68 AKT3 C
ATOM 1615 O LEU A 354 36.239 27.850 48.168 39.19 AKT3 O
ATOM 1616 N PHE A 355 36.166 25.623 47.884 40.45 AKT3 N
ATOM 1617 CA PHE A 355 35.364 25.436 49.081 41.41 AKT3 C
ATOM 1618 CB PHE A 355 35.047 23.957 49.283 42.06 AKT3 C
ATOM 1619 CG PHE A 355 34.216 23.366 48.183 42.48 AKT3 C
ATOM 1620 CDl PHE A 355 33.212 24.108 47.589 42.78 AKT3 C
ATOM 1621 CD2 PHE A 355 34.412 22.060 47.772 43.41 AKT3 C
ATOM 1622 CEl PHE A 355 32.414 23.560 46.606 1.00 43.18 AKT3 C
ATOM 1523 CE2 PHE A 355 33.618 21.502 46.788 42.71 AKT3 C
ATOM 1624 CZ PHE A 355 32.617 22.252 46.205 42.99 AKT3 C
ATOM 1625 C PHE A 355 36.061 26.002 50.310 41.37 AKT3 C
ATOM 1626 O PHE A 355 35.403 26.445 51.265 40.98 AKT3 O
ATOM 1627 N GLU A 356 37.392 25.993 50.279 41.37 AKT3 N
ATOM 1628 CA GLU A 356 38.191 26.519 51.394 41.60 AKT3 C
ATOM 1629 CB GLU A 356 39.696 26.269 51.166 43.83 AKT3 C
ATOM 1630 CG GLU A 356 40.207 24.844 51.453 46.07 AKT3 C
ATOM 1631 CD GLU A 356 40.720 24.684 52.879 47.50 AKT3 C
ATOM 1632 OEl GLU A 356 41.331 23.626 53.193 46.28 AKT3 O
ATOM 1633 OE2 GLU A 356 40.503 25.628 53.682 48.80 AKT3 O
ATOM 1634 C GLU A 356 37.942 28.017 51.483 39.64 AKT3 C
ATOM 1635 O GLU A 356 37.807 28.576 52.574 39.30 AKT3 O
ATOM 1636 N LEU A 357 37.893 28.668 50.321 38.01 AKT3 N
ATOM 1637 CA LEU A 357 37.652 30.101 50.287 35.55 AKT3 C
ATOM 1638 CB LEU A 357 37.838 30.665 48.870 36.11 AKT3 C
ATOM 1639 CG LEU A 357 39.158 30.414 48.131 36.93 AKT3 C
ATOM 1640 CDl LEU A 357 39.094 29.080 47.394 36.30 AKT3 C
ATOM 1641 CD2 LEU A 357 39.404 31.534 47.137 35.04 AKT3 C
ATOM 1642 C LEU A 357 36.220 30.346 50.748 33.07 AKT3 C
ATOM 1643 O LEU A 357 35.982 31.148 51.643 32.06 AKT3 O
ATOM 1644 N ILE A 358 35.273 29.639 50.141 30.82 AKT3 M
ATOM 1645 CA ILE A 358 33.874 29.807 50.499 29.96 AKT3 C
ATOM 1646 CB ILE A 358 32.971 28.800 49.777 29.67 AKT3 C
ATOM 1647 CG2 ILE A 358 31.533 28.936 50.291 27.16 AKT3 C
ATOM 1648 CGl ILE A 358 33.033 29.032 48.268 27.57 AKT3 C
ATOM 1649 CDl ILE A 358 31.997 28.266 47.502 24.37 AKT3 C
ATOM 1650 C ILE A 358 33.633 29.665 51.994 30.45 AKT3 C
ATOM 1651 O ILE A 358 32.892 30.446 52.581 30.49 AKT3 O
ATOM 1652 N LEU A 359 34.264 28.676 52.614 30.53 AKT3 N
ATOM 1653 CA LEU A 359 34.076 28.460 54.045 31.28 AKT3 C
ATOM 1654 CB LEU A 359 34.245 26.982 54.391 31.18 AKT3 C
ATOM 1655 CG LEU A 359 33.017 26.088 54.253 31.87 AKT3 C
ATOM 1656 CDl LEU A 359 32.251 26.417 52.975 33.26 AKT3 C
ATOM 1657 CD2 LEU A 359 33.472 24.644 54.260 32.23 AKT3 C
ATOM 1658 C LEU A 359 35.021 29.249 54.920 31.75 AKT3 C
ATOM 1659 O LEU A 359 34.703 29.553 56.066 31.83 AKT3 O
ATOM 1660 N MET A 360 36.176 29.601 54.379 32.70 AKT3 N
ATOM 1661 CA MET A 360 37.167 30.290 55.176 33.44 AKT3 C
ATOM 1662 CB MET A 360 38.453 29.468 55.154 35.47 AKT3 C
ATOM 1663 CG MET A 360 38.278 28.003 55.588 1.00 38.66 AKT3 C ATOM 1664 SD MET A 360 38.517 27.741 57.375 1.00 41.99 AKT3 S
ATOM 1665 CE MET A 360 36.819 28.112 58.026 1.00 40.79 AKT3 C
ATOM 1666 C MET A 360 37.501 31.735 54.842 1.00 33.38 AKT3 C
ATOM 1667 O MET A 360 37.596 32.571 55.737 1.00 32.35 AKT3 O
ATOM 1668 N GLU A 361 37.688 32.028 53.560 1.00 35.06 AKT3 N
ATOM 1669 CA GLU A 361 38.095 33.366 53.136 1.00 35.70 AKT3 C
ATOM 1670 CB GLU A 361 38.739 33.281 51.761 1.00 37.16 AKT3 C
ATOM 1671 CG GLU A 361 39.779 32.181 51.720 1.00 42.62 AKT3 C
ATOM 1672 CD GLU A 361 40.882 32.367 52.763 1.00 45.02 AKT3 C
ATOM 1673 OEl GLU A 361 41.792 33.212 52.519 1.00 47.41 AKT3 O
ATOM 1674 OE2 GLU A 361 40.837 31.677 53.823 1.00 44.52 AKT3 O
ATOM 1675 C GLU A 361 37.087 34.489 53.150 1.00 34.93 AKT3 C
ATOM 1676 O GLU A 361 35.936 34.338 52.732 1.00 33.59 AKT3 O
ATOM 1677 N ASP A 362 37.554 35.625 53.660 1.00 34.65 AKT3 N
ATOM 1678 CA ASP A 362 36.762 36.840 53.744 1.00 35.02 AKT3 C
ATOM 1679 CB ASP A 362 37.423 37.823 54.701 1.00 37.19 AKT3 C
ATOM 1680 CG ASP A 362 36.822 37.782 56.086 1.00 40.32 AKT3 C
ATOM 1681 ODl ASP A 362 35.780 38.448 56.302 1.00 41.58 AKT3 O
ATOM 1682 OD2 ASP A 362 37.392 37.082 56.957 1.00 41.59 AKT3 O
ATOM 1683 C ASP A 362 36.697 37.462 52.357 1.00 33.59 AKT3 C
ATOM 1684 O ASP A 362 37.678 37.424 51.604 1.00 32.92 AKT3 O
ATOM 1685 N ILE A 363 35.541 38.021 52.010 1.00 32.06 AKT3 N
ATOM 1686 CA ILE A 363 35.408 38.661 50.712 1.00 30.05 AKT3 C
ATOM 1687 CB ILE A 363 33.933 39.020 50.360 1.00 29.48 AKT3 C
ATOM 1688 CG2 ILE A 363 33.415 38.063 49.314 1.00 28.19 AKT3 C
ATOM 1689 CGl ILE A 363 33.053 39.023 51.620 1.00 30.37 AKT3 C
ATOM 1690 CDl ILE A 363 33.525 39.964 52.723 1.00 31.78 AKT3 C
ATOM 1691 C ILE A 363 36.217 39.945 50.705 1.00 29.17 AKT3 C
ATOM 1692 O ILE A 363 36.467 40.542 51.748 1.00 28.41 AKT3 O
ATOM 1693 N LYS A 364 36.646 40.345 49.516 1.00 29.76 AKT3 N
ATOM 1694 CA LYS A 364 37.396 41.577 49.343 1.00 29.98 AKT3 C
ATOM 1695 CB LYS A 364 38.790 41.281 48.771 1.00 32.30 AKT3 C
ATOM 1696 CG LYS A 364 39.598 40.234 49.545 1.00 34.48 AKT3 C
ATOM 1697 CD LYS A 364 40.751 40.865 50.300 1.00 35.97 AKT3 C
ATOM 1698 CE LYS A 364 40.263 41.707 51.466 1.00 38.86 AKT3 C
ATOM 1699 NZ LYS A 364 39.687 40.826 52.521 1.00 39.56 AKT3 N
ATOM 1700 C LYS A 364 36.554 42.368 48.333 1.00 29.12 AKT3 C
ATOM 1701 O LYS A 364 35.771 41.775 47.587 1.00 27.38 AKT3 O
ATOM 1702 N PHE A 365 36.690 43.692 48.331 1.00 27.92 AKT3 N
ATOM 1703 CA PHE A 365 35.931 44.533 47.408 1.00 26.57 AKT3 C
ATOM 1704 CB PHE A 365 34.767 45.263 48.090 1.00 24.08 AKT3 C
ATOM 1705 CG PHE A 365 34.039 44.476 49.140 1.00 22.17 AKT3 C
ATOM 1706 CDl PHE A 365 33.036 43.587 48.796 1.00 20.12 AKT3 C
ATOM 1707 CD2 PHE A 365 34.281 44.718 50.490 1.00 19.82 AKT3 C
ATOM 1708 CEl PHE A 365 32.279 42.962 49.787 1.00 20.37 AKT3 C
ATOM 1709 CE2 PHE A 365 33.533 44.100 51.474 1.00 18.34 AKT3 C
ATOM 1710 CZ PHE A 365 32.527 43.220 51.125 1.00 17.32 AKT3 C
ATOM 1711 C PHE A 365 36.807 45.646 46.862 1.00 27.37 AKT3 C
ATOM 1712 O PHE A 365 37.817 46.014 47.449 1.00 27.75 AKT3 O
ATOM 1713 N PRO A 366 36.412 46.207 45.719 1.00 28.28 AKT3 N
ATOM 1714 CD PRO A 366 35.301 45.806 44.833 1.00 27.66 AKT3 C
ATOM 1715 CA PRO A 366 37.191 47.304 45.149 1.00 28.20 AKT3 C
ATOM 1716 CB PRO A 366 36.396 47.667 43.895 1.00 27.46 AKT3 C
ATOM 1717 CG PRO A 366 35.725 46.380 43.517 1.00 26.51 AKT3 C
ATOM 1718 C PRO A 366 37.085 48.400 46.230 1.00 30.06 AKT3 C
ATOM 1719 O PRO A 366 35.998 48.593 46.791 1.00 30.16 AKT3 O
ATOM 1720 N ARG A 367 38.181 49.102 46.538 1.00 30.78 AKT3 N
ATOM 1721 CA ARG A 367 38.131 50.142 47.574 1.00 31.10 AKT3 C
ATOM 1722 CB ARG A 367 39.507 50.808 47.796 1.00 34.57 AKT3 C
ATOM 1723 CG ARG A 367 40.589 49.941 48.498 1.00 39.89 AKT3 C
ATOM 1724 CD ARG A 367 40.214 49.443 49.925 1.00 42.16 AKT3 C
ATOM 1725 NE ARG A 367 40.261 50.455 50.996 1.00 44.54 AKT3 N
ATOM 1726 CZ ARG A 367 41.367 51.061 51.444 1.00 46.35 AKT3 C
ATOM 1727 NHl ARG A 367 42.564 50.782 50.920 1.00 46.13 AKT3 N
ATOM 1728 NH2 ARG A 367 41.282 51.948 52.438 1.00 46.08 AKT3 N
ATOM 1729 C ARG A 367 37.107 51.231 47.268 1.00 29.38 AKT3 C
ATOM 1730 O ARG A 367 36.519 51.803 48.192 1.00 28.54 AKT3 O
ATOM 1731 N THR A 368 36.897 51.512 45.980 1.00 27.04 AKT3 N
ATOM 1732 CA THR A 368 35.961 52.552 45.555 1.00 26.01 AKT3 C
ATOM 1733 CB THR A 368 36.155 52.894 44.068 1.00 27.05 AKT3 C
ATOM 1734 OGl THR A 368 36.132 51.684 43.295 1.00 28.86 AKT3 O
ATOM 173S CG2 THR A 368 31.All 53.640 43.857 1.00 26.53 AKT3 C
ATOM 1736 C THR A 368 34.475 52.251 45.787 1.00 24.97 AKT3 C ATOM 1737 O THR A 368 33.635 53.151 45.735 1.00 24.57 AKT3 O
ATOM 1738 N LEU A 369 34.145 50.994 46.038 1.00 22.00 AKT3 N
ATOM 1739 CA LEU A 369 32.763 50.637 46.287 1.00 20.50 AKT3 C
ATOM 1740 CB LEU A 369 32.658 49.148 46.574 1.00 20.14 AKT3 C
ATOM 1741 CG LEU A 369 31.246 48.584 46.518 1.00 20.58 AKT3 C
ATOM 1742 CDl LEU A 369 30.632 48.903 45.157 1.00 19.84 AKT3 C
ATOM 1743 CD2 LEU A 369 31.296 47.076 46.767 1.00 20.11 AKT3 C
ATOM 1744 C LEU A 369 32.289 51.432 47.496 1.00 19.93 AKT3 C
ATOM 1745 O LEU A 369 33.044 51.633 48.440 1.00 21.22 AKT3 O
ATOM 1746 N SER A 370 31.039 51.879 47.479 1.00 18.19 AKT3 N
ATOM 1747 CA SER A 370 30.527 52.662 48.593 1.00 17.39 AKT3 C
ATOM 1748 CB SER A 370 29.108 53.182 48.306 1.00 15.41 AKT3 C
ATOM 1749 OG SER A 370 28.129 52.178 48.481 1.00 15.37 AKT3 O
ATOM 1750 C SER A 370 30.517 51.887 49.897 1.00 16.76 AKT3 C
ATOM 1751 O SER A 370 30.349 50.667 49.922 1.00 17.64 AKT3 O
ATOM 1752 N SER A 371 30.701 52.625 50.979 1.00 16.44 AKT3 N
ATOM 1753 CA SER A 371 30.702 52.072 52.318 1.00 16.19 AKT3 C
ATOM 1754 CB SER A 371 30.766 53.215 53.338 1.00 14.71 AKT3 C
ATOM 1755 OG SER A 371 30.499 52.743 54.643 1.00 14.65 AKT3 O
ATOM 1756 C SER A 371 29.454 51.219 52.565 1.00 15.21 AKT3 C
ATOM 1757 O SER A 371 29.550 50.117 53.102 1.00 13.81 AKT3 O
ATOM 1758 N ASP A 372 28.289 51.737 52.177 1.00 15.60 AKT3 N
ATOM 1759 CA ASP A 372 27.036 51.011 52.375 1.00 15.07 AKT3 C
ATOM 1760 CB ASP A 372 25.838 51.853 51.917 1.00 16.37 AKT3 C
ATOM 1761 CG ASP A 372 25.511 52.975 52.872 1.00 16.18 AKT3 C
ATOM 1762 ODl ASP A 372 25.540 52.747 54.087 1.00 18.73 AKT3 O
ATOM 1763 OD2 ASP A 372 25.210 54.087 52.415, 1.00 18.82 AKT3 O
ATOM 1764 C ASP A 372 27.013 49.670 51.640 1.00 14.95 AKT3 C
ATOM 1765 O ASP A 372 26.594 48.658 52.192 1.00 15.42 AKT3 O
ATOM 1766 N ALA A 373 27.462 49.674 50.392 1.00 14.13 AKT3 N
ATOM 1767 CA ALA A 373 27.477 48.468 49.590 1.00 14.65 AKT3 C
ATOM 1768 CB ALA A 373 27.966 48.792 48.188 1.00 13.46 AKT3 C
ATOM 1769 C ALA A 373 28.327 47.360 50.202 1.00 14.42 AKT3 C
ATOM 1770 O ALA A 373 27.886 46.227 50.305 1.00 15.38 AKT3 O
ATOM 1771 N LYS A 374 29.548 47.689 50.606 1.00 15.52 AKT3 N
ATOM 1772 CA LYS A 374 30.442 46.693 51.183 1.00 16.73 AKT3 C
ATOM 1773 CB LYS A 374 31.783 47.322 51.549 1.00 17.15 AKT3 C
ATOM 1774 CG LYS A 374 32.509 47.949 50.375 1.00 19.36 AKT3 C
ATOM 1775 CD LYS A 374 33.790 48.590 50.849 1.00 20.98 AKT3 C
ATOM 1776 CE LYS A 374 34.314 49.588 49.843 1.00 20.97 AKT3 C
ATOM 1777 NZ LYS A 374 35.533 50.261 50.363 1.00 23.55 AKT3 N
ATOM 1778 C LYS A 374 29.793 46.125 52.418 1.00 16.23 AKT3 C
ATOM 1779 O LYS A 374 29.848 44.925 52.679 1.00 14.79 AKT3 O
ATOM 1780 N SER A 375 29.175 47.017 53.175 1.00 15.39 AKT3 N
ATOM 1781 CA SER A 375 28.476 46.643 54.382 1.00 15.70 AKT3 C
ATOM 1782 CB SER A 375 27.798 47.875 54.977 1.00 16.89 AKT3 C
ATOM 1783 OG SER A 375 26.677 47.522 55.760 1.00 17.60 AKT3 O
ATOM 1784 C SER A 375 27.438 45.592 54.012 1.00 15.97 AKT3 C
ATOM 1785 O SER A 375 27.349 44.550 54.650 1.00 16.72 AKT3 O
ATOM 1786 N LEU A 376 26.674 45.876 52.962 1.00 14.66 AKT3 N
ATOM 1787 CA LEU A 376 25.629 44.986 52.480 1.00 13.85 AKT3 C
ATOM 1788 CB LEU A 376 24.903 45.610 51.276 1.00 13.64 AKT3 C
ATOM 1789 CG LEU A 376 23.696 44.814 50.746 1.00 14.81 AKT3 C
ATOM 1790 CDl LEU A 376 22.473 45.103 51.603 1.00 14.79 AKT3 C
ATOM 1791 CD2 LEU A 376 23.411 45.180 49.308 1.00 14.60 AKT3 C
ATOM 1792 C LEU A 376 26.176 43.620 52.076 1.00 12.68 AKT3 C
ATOM 1793 O LEU A 376 25.744 42.596 52.590 1.00 9.09 AKT3 O
ATOM 1794 N LEU A 377 27.113 43.615 51.137 1.00 11.01 AKT3 N
ATOM 1795 CA LEU A 377 27.700 42.378 50.666 1.00 11.53 AKT3 C
ATOM 1796 CB LEU A 377 28.737 42.665 49.592 1.00 9.91 AKT3 C
ATOM 1797 CG LEU A 377 28.238 43.475 48.398 1.00 11.13 AKT3 C
ATOM 1798 CDl LEU A 377 29.405 43.756 47.467 1.00 9.15 AKT3 C
ATOM 1799 CD2 LEU A 377 27.137 42.717 47.673 1.00 9.90 AKT3 C
ATOM 1800 C LEU A 377 28.351 41.641 51.820 1.00 12.64 AKT3 C
ATOM 1801 O LEU A 377 28.245 40.421 51.929 1.00 14.44 AKT3 O
ATOM 1802 N SER A 378 29.031 42.387 52.678 1.00 13.09 AKT3 N
ATOM 1803 CA SER A 378 29.689 41.797 53.832 1.00 15.01 AKT3 C
ATOM 1804 CB SER A 378 30.349 42.879 54.692 1.00 16.76 AKT3 C
ATOM 1805 OG SER A 378 31.220 43.700 53.936 1.00 20.46 AKT3 O
ATOM 1806 C SER A 378 28.652 41.064 54.669 1.00 14.47 AKT3 C
ATOM 1807 O SER A 378 28.804 39.876 54.955 1.00 14.98 AKT3 O
ATOM 1808 N GLY A 379 27.604 41.795 55.055 1.00 12.97 AKT3 N
ATOM 1809 CA GLY A 379 26.538 41.241 55.868 1.00 12.96 AKT3 C ATOM 1810 C GLY A 379 25.835 40.073 55.219 1.00 13.99 AKT3 C
ATOM 1811 O GLY A 379 25.486 39.108 55.878 1.00 15.72 AKT3 O
ATOM 1812 N LEU A 380 25.635 40.166 53.914 1.00 15.17 AKT3 N
ATOM 1813 CA LEU A 380 24.974 39.120 53.159 1.00 15.39 AKT3 C
ATOM 1814 CB LEU A 380 24.563 39.63S 51.780 1.00 15.75 AKT3 C
ATOM 1815 CG LEU A 380 23.372 40.589 51.677 1.00 17.16 AKT3 C
ATOM 1816 CDl LEU A 380 23.209 41.064 50.227 1.00 13.04 AKT3 C
ATOM 1817 CD2 LEU A 380 22.112 39.872 52.189 1.00 16.23 AKT3 C
ATOM 1818 C LEU A 380 25.855 37.901 52.971 1.00 17.10 AKT3 C
ATOM 1819 O LEU A 380 25.351 36.796 52.817 1.00 17.77 AKT3 O
ATOM 1820 N LEU A 381 27.168 38.094 52.969 1.00 17.24 AKT3 N
ATOM 1821 CA LEU A 381 28.074 36.972 52.759 1.00 17.92 AKT3 C
ATOM 1822 CB LEU A 381 29.148 37.341 51.730 1.00 16.96 AKT3 C
ATOM 1823 CG LEU A 381 28.669 37.824 50.350 1.00 18.55 AKT3 C
ATOM 1824 CDl LEU A 381 29.827 38.454 49.619 1.00 15.32 AKT3 C
ATOM 1825 CD2 LEU A 381 28.080 36.672 49.545 1.00 15.97 AKT3 C
ATOM 1826 C LEU A 381 28.736 36.483 54.034 1.00 18.40 AKT3 C
ATOM 1827 O LEU A 381 29.809 35.887 53.991 1.00 18.48 AKT3 O
ATOM 1828 N ILE A 382 28.101 36.733 55.168 1.00 18.17 AKT3 N
ATOM 1829 CA ILE A 382 28.649 36.283 56.434- 1.00 19.87 AKT3 C
ATOM 1830 CB ILE A 382 27.889 36.913 57.609 1.00 19.96 AKT3 C
ATOM 1831 CG2 ILE A 382 28.069 36.072 58.851 1.00 18.31 AKT3 C
ATOM 1832 CGl ILE A 382 28.362 38.359 57.807 1.00 18.16 AKT3 C
ATOM 1833 CDl ILE A 382 27.517 39.160 58.766 1.00 17.47 AKT3 C
ATOM 1834 C ILE A 382 28.531 34.760 56.490 1.00 21.60 AKT3 C
ATOM 1835 O ILE A 382 27.460 34.215 56.235 1.00 23.64 AKT3 O
ATOM 1836 N LYS A 383 29.630 34.084 56.825 1.00 21.44 AKT3 N
ATOM 1837 CA LYS A 383 29.677 32.618 56.885 1.00 22.05 AKT3 C
ATOM 1838 CB LYS A 383 31.088 32.162 57.282 1.00 20.25 AKT3 C
ATOM 1839 CG LYS A 383 32.225 32.830 56.519 1.00 19.28 AKT3 C
ATOM 1840 CD LYS A 383 32.267 32.450 55.055 1.00 16.67 AKT3 C
ATOM 1841 CE LYS A 383 33.537 32.997 54.387 1.00 17.74 AKT3 C
ATOM 1842 NZ LYS A 383 33.603 32.739 52.908 1.00 16.70 AKT3 N
ATOM 1843 C LYS A 383 28.638 31.899 57.788 1.00 21.34 AKT3 C
ATOM 1844 O LYS A 383 28.122 30.856 57.415 1.00 20.94 AKT3 O
ATOM 1845 N ASP A 384 28.360 32.434 58.975 1.00 21.89 AKT3 N
ATOM 1846 CA ASP A 384 27.376 31.826 59.878 1.00 20.77 AKT3 C
ATOM 1847 CB ASP A 384 27.699 32.172 61.342 1.00 20.97 AKT3 C
ATOM 1848 CG ASP A 384 26.837 31.399 62.343 1.00 21.92 AKT3 C
ATOM 1849 ODl ASP A 384 25.697 31.026 62.017 1.00 21.84 AKT3 O
ATOM 1850 0D2 ASP A 384 27.295 31.176 63.480 1.00 22.86 AKT3 O
ATOM 1851 C ASP A 384 26.018 32.412 59.491 1.00 20.23 AKT3 C
ATOM 1852 O ASP A 384 25.819 33.632 59.527 1.00 19.58 AKT3 O
ATOM 1853 N PRO A 385 25.070 31.550 59.095 1.00 19.03 AKT3 N
ATOM 1854 CD PRO A 385 25.263 30.109 58.871 1.00 19.35 AKT3 C
ATOM 1855 CA PRO A 385 23.724 31.960 58.688 1.00 19.16 AKT3 C
ATOM 1856 CB PRO A 385 23.162 30.699 58.040 1.00 19.03 AKT3 C
ATOM 1857 CG PRO A 385 23.835 29.615 58.777 1.00 19.96 AKT3 C
ATOM 1858 C PRO A 385 22.836 32.483 59.804 1.00 20.50 AKT3 C
ATOM 1859 O PRO A 385 21.846 33.169 59.549 1.00 20.46 AKT3 O
ATOM 1860 N ASN A 386 23.201 32.164 61.041 1.00 21.44 AKT3 N
ATOM 1861 CA ASN A 386 22.441 32.590 62.212 1.00 21.80 AKT3 C
ATOM 1862 CB ASN A 386 22.834 31.747 63.423 1.00 21.52 AKT3 C
ATOM 1863 CG ASN A 386 22.502 30.291 63.234 1.00 22.81 AKT3 C
ATOM 1864 ODl ASN A 386 23.297 29.405 63.567 1.00 24.68 AKT3 O
ATOM 1865 ND2 ASN A 386 21.318 30.028 62.692 1.00 19.78 AKT3 N
ATOM 1866 C ASN A 386 22.693 34.048 62.504 1.00 20.77 AKT3 C
ATOM 1867 O ASN A 386 21.988 34.668 63.292 1.00 20.72 AKT3 O
ATOM 1868 N LYS A 387 23.717 34.595 61.874 1.00 20.75 AKT3 N
ATOM 1869 CA LYS A 387 24.030 35.990 62.079 1.00 22.00 AKT3 C
ATOM 1870 CB LYS A 387 25.296 36.130 62.926 1.00 23.88 AKT3 C
ATOM 1871 CG LYS A 387 26.308 35.039 62.731 1.00 26.60 AKT3 C
ATOM 1872 CD LYS A 387 27.273 35.023 63.909 1.00 30.35 AKT3 C
ATOM 1873 CE LYS A 387 26.528 35.160 65.237 1.00 32.40 AKT3 C
ATOM 1874 NZ LYS A 387 25.347 34.234 65.325 1.00 35.09 AKT3 N
ATOM 1875 C LYS A 387 24.165 36.734 60.766 1.00 20.83 AKT3 C
ATOM 1876 O LYS A 387 24.415 37.937 60.752 1.00 21.93 AKT3 O
ATOM 1877 N ARG A 388 23.976 36.021 59.663 1.00 19.24 AKT3 N
ATOM 1878 CA ARG A 388 24.064 36.639 58.353 1.00 19.25 AKT3 C
ATOM 1879 CB ARG A 388 23.944 35.568 57.271 1.00 19.55 AKT3 C
ATOM 1880 CG ARG A 388 24.300 36.032 55.874 1.00 20.16 AKT3 C
ATOM 1881 CD ARG A 388 24.998 34.902 55.113 1.00 22.37 AKT3 C
ATOM 1882 NE ARG A 388 24.076 33.852 54.693 1.00 23.03 AKT3 N ATOM 1883 CZ ARG A 388 24.276 32.545 54.863 1.00 23.34 AKT3 C
ATOM 1884 NHl ARG A 388 25.375 32.091 55.454 1.00 23.13 AKT3 N
ATOM 1885 NH2 ARG A 388 23.364 31.687 54.436 1.00 21.39 AKT3 N
ATOM 1886 C ARG A 388 22.928 37.654 58.209 1.00 19.46 AKT3 C
ATOM 1887 O ARG A 388 21.843 37.453 58.750 1.00 20.56 AKT3 O
ATOM 1888 N LEU A 389 23.187 38.745 57.497 1.00 18.27 AKT3 N
ATOM 1889 CA LEU A 389 22.169 39.765 57.263 1.00 18.00 AKT3 C
ATOM 1890 CB LEU A 389 22.690 40.821 56.286 1.00 16.84 AKT3 C
ATOM 1891 CG LEU A 389 21.708 41.955 55.971 1.00 16.84 AKT3 C
ATOM 1892 CDl LEU A 389 21.540 42.841 57.199 1.00 13.92 AKT3 C
ATOM 1893 CD2 LEU A 389 22.210 42.761 54.798 1.00 14.55 AKT3 C
ATOM 1894 C LEU A 389 20.909 39.123 56.676 1.00 17.06 AKT3 C
ATOM 1895 O LEU A 389 20.970 38.473 55.635 1.00 15.01 AKT3 O
ATOM 1896 N GLY A 390 19.773 39.314 57.345 1.00 16.90 AKT3 N
ATOM 1897 CA GLY A 390 18.526 38.739 56.872 1.00 16.48 AKT3 C
ATOM 1898 C GLY A 390 18.325 37.327 57.389 1.00 17.42 AKT3 C
ATOM 1899 O GLY A 390 17.289 36.705 57.145 1.00 17.34 AKT3 O
ATOM 1900 K GLY A 391 19.330 36.820 58.104 1.00 17.07 AKT3 N
ATOM 1901 CA GLY A 391 19.261 35.485 58.659 1.00 18.15 AKT3 C
ATOM 1902 C GLY A 391 18.517 35.454 59.984 1.00 20.18 AKT3 C
ATOM 1903 O GLY A 391 18.133 34.381 60.462 1.00 20.80 AKT3 O
ATOM 1904 N GLY A 392 18.317 36.632 50.576 1.00 19.79 AKT3 N
ATOM 1905 CA GLY A 392 17.601 36.730 61.834 1.00 19.77 AKT3 C
ATOM 1906 C GLY A 392 16.106 36.482 61.681 1.00 20.68 AKT3 C
ATOM 1907 O GLY A 392 15.609 36.243 60.574 1.00 21.07 AKT3 O
ATOM 1908 N PRO A 393 15.357 36.544 62.790 1.00 19.32 AKT3 N
ATOM 1909 CD PRO A 393 15.866 36.917 64.118 1.00 18.80 AKT3 C
ATOM 1910 CA PRO A 393 13.908 36.330 62.835 1.00 18.57 AKT3 C
ATOM 1911 CB PRO A 393 13.579 36.516 64.315 1.00 17.94 AKT3 C
ATOM 1912 CG PRO A 393 14.624 37.456 64.782 1.00 19.32 AKT3 C
ATOM 1913 C PRO A 393 13.049 37.218 61.946 1.00 18.20 AKT3 C
ATOM 1914 O PRO A 393 11.901 36.881 61.673 1.00 18.47 AKT3 O
ATOM 1915 N ASP A 394 13.589 38.344 61.491 1.00 17.58 AKT3 N
ATOM 1916 CA ASP A 394 12.802 39.236 60.648 1.00 18.32 AKT3 C
ATOM 1917 CB ASP A 394 13.050 40.687 61.052 1.00 17.89 AKT3 C
ATOM 1918 CG ASP A 394 11.767 41.462 61.192 1.00 19.84 AKT3 C
ATOM 1919 ODl ASP A 394 10.703 40.810 61.189 1.00 20.74 AKT3 O
ATOM 1920 OD2 ASP A 394 11.813 42.707 61.312 1.00 19.48 AKT3 O
ATOM 1921 C ASP A 394 13.037 39.042 59.140 1.00 18.33 AKT3 C
ATOM 1922 O ASP A 394 12.393 39.682 58.306 1.00 18.29 AKT3 O
ATOM 1923 N ASP A 395 13.967 38.152 58.813 1.00 18.50 AKT3 N
ATOM 1924 CA ASP A 395 14.281 37.815 57.437 1.00 18.83 AKT3 C
ATOM 1925 CB ASP A 395 13.142 36.964 56.855 1.00 19.13 AKT3 C
ATOM 1926 CG ASP A 395 13.480 36.388 55.494 1.00 19.92 AKT3 C
ATOM 1927 ODl ASP A 395 14.520 35.719 55.373 1.00 19.83 AKT3 O
ATOM 1928 OD2 ASP A 395 12.710 36.605 54.539 1.00 21.29 AKT3 O
ATOM 1929 C ASP A 395 14.566 39.007 56.521 1.00 18.81 AKT3 C
ATOM 1930 O ASP A 395 15.427 39.839 56.794 1.00 19.23 AKT3 O
ATOM 1931 N ALA A 396 13.835 39.075 55.422 1.00 16.92 AKT3 N
ATOM 1932 CA ALA A 396 14.028 40.131 54.459 1.00 16.92 AKT3 C
ATOM 1933 CB ALA A 396 12.985 40.011 53.371 1.00 16.05 AKT3 C
ATOM 1934 C ALA A 396 14.023 41.543 55.040 1.00 17.22 AKT3 C
ATOM 1935 O ALA A 396 14.733 42.419 54.538 1.00 16.09 AKT3 O
ATOM 1936 N LYS A 397 13.236 41.771 56.089 1.00 16.44 AKT3 N
ATOM 1937 CA LYS A 397 13.156 43.104 56.680 1.00 16.12 AKT3 C
ATOM 1938 CB LYS A 397 12.229 43.113 57.903 1.00 17.80 AKT3 C
ATOM 1939 CG LYS A 397 10.734 43.104 57.576 1.00 17.53 AKT3 C
ATOM 1940 CD LYS A 397 10.281 41.738 57.084 1.00 22.39 AKT3 C
ATOM 1941 CE LYS A 397 8.802 41.734 56.713 1.00 25.51 AKT3 C
ATOM 1942 NZ LYS A 397 8.510 42.457 55.432 1.00 28.41 AKT3 N
ATOM 1943 C LYS A 397 14.506 43.694 57.069 1.00 15.66 AKT3 C
ATOM 1944 O LYS A 397 14.585 44.910 57.052 1.00 15.05 AKT3 O
ATOM 1945 N GLU A 398 15.453 42.828 57.404 1.00 14.54 AKT3 N
ATOM 1946 CA GLU A 398 16.778 43.263 57.813 1.00 14.94 AKT3 C
ATOM 1947 CB GLU A 398 17.578 42.065 58.326 1.00 14.95 AKT3 C
ATOM 1948 CG GLU A 398 16.779 41.226 59.317 1.00 17.05 AKT3 C
ATOM 1949 CD GLU A 398 17.644 40.354 60.200 1.00 18.24 AKT3 C
ATOM 1950 OEl GLU A 398 17.116 39.819 61.206 1.00 18.98 AKT3 O
ATOM 1951 OE2 GLU A 398 18.842 40.208 59.888 1.00 17.26 AKT3 O
ATOM 1952 C GLU A 398 17.500 43.923 56.656 1.00 15.48 AKT3 C
ATOM 1953 O GLU A 398 18.176 44.937 56.820 1.00 17.06 AKT3 O
ATOM 1954 N ILE A 399 17.332 43.348 55.478 1.00 15.08 AKT3 N
ATOM 1955 CA ILE A 399 17.960 43.860 54.278 1.00 13.40 AKT3 C ATOM 1956 CB ILE A 399 17.876 42.799 53.190 00 13.35 AKT3 C
ATOM 1957 CG2 ILE A 399 18.512 43.300 51.922 00 11.30 AKT3 C
ATOM 1958 CGl ILE A 399 18.522 41.513 53.722 00 12.10 AKT3 C
ATOM 1959 CDl ILE A 399 18.216 40.267 52.940 00 15.89 AKT3 C
ATOM 1960 C ILE A 399 17.250 45.135 53.860 00 15.33 AKT3 C
ATOM 1961 O ILE A 399 17.880 46.125 53.488 00 15.66 AKT3 O
ATOM 1962 N MET A 400 15.926 45.114 53.952 00 16.55 AKT3 N
ATOM 1963 CA MET A 400 15.127 46.274 53.599 00 17.28 AKT3 C
ATOM 1964 CB MET A 400 13.642 45.920 53.681 1.00 16.56 AKT3 C
ATOM 1965 CG MET A 400 13.238 44.841 52.677 1.00 16.65 AKT3 C
ATOM 1966 SD MET A 400 11.594 44.153 52.944 1 00 16.54 AKT3 S
ATOM 1967 CE MET A 400 10.600 45.645 52.764 1 OO 16.73 AKT3 C
ATOM 1968 C MET A 400 15.457 47.451 54.519 1 00 17.88 AKT3 C
ATOM 1969 O MET A 400 15.255 48.602 54.156 1 00 19.20 AKT3 O
ATOM 1970 N ARG A 401 15.973 47.164 55.707 1 00 17.50 AKT3 N
ATOM 1971 CA ARG A 401 16.323 48.232 56.631 1 00 18.50 AKT3 C
ATOM 1972 CB ARG A 401 15.937 47.858 58.064 1 00 18.09 AKT3 C
ATOM 1973 CG ARG A 401 14.435 47.748 58.289 1 00 19.00 AKT3 C
ATOM 1974 CD ARG A 401 14.125 47.656 59.757 1 00 18.68 AKT3 C
ATOM 1975 NE ARG A 401 14.750 46.494 60.370 1 00 19.77 AKT3 N
ATOM 1976 CZ ARG A 401 14.072 45.438 60.802 1 OO 20.89 AKT3 C
ATOM 1977 NHl ARG A 401 12.755 45.420 60.683 1 00 21.17 AKT3 N
ATOM 1978 NH2 ARG A 401 14.703 44.400 61.339 1 00 21.60 AKT3 N
ATOM 1979 C ARG A 401 17.810 48.565 56.573 1.00 19.29 AKT3 C
ATOM 1980 O ARG A 401 18.298 49.386 57.344 19.68 AKT3 O
ATOM 1981 N HIS A 402 18.534 47.926 55.660 17.91 AKT3 N
ATOM 1982 CA HIS A 402 19.959 48.193 55.536 15.55 AKT3 C
ATOM 1983 CB HIS A 402 20.657 47.056 54.784 15.53 AKT3 C
ATOM 1984 CG HIS A 402 22.152 47.157 54.797 17.52 AKT3 C
ATOM 1985 CD2 HIS A 402 23.089 46.410 55.425 17.04 AKT3 C
ATOM 1986 NDl HIS A 402 22.839 48.151 54.134 18.74 AKT3 N
ATOM 1987 CEl HIS A 402 24.134 48.014 54.351 16.61 AKT3 C
ATOM 1988 NE2 HIS A 402 24.313 46.965 55.132 19.10 AKT3 N
ATOM 1989 C HIS A 402 20.160 49.520 54.807 15.15 AKT3 C
ATOM 1990 O HIS A 402 19.466 49.816 53.828 13.76 AKT3 O
ATOM 1991 N SER A 403 21.118 50.305 55.292 15.16 AKT3 N
ATOM 1992 CA SER A 403 21.420 51.620 54.733 15.57 AKT3 C
ATOM 1993 CB SER A 403 22.608 52.237 55.473 14.50 AKT3 C
ATOM 1994 OG SER A 403 23.765 51.459 55.294 17.55 AKT3 O
ATOM 1995 C SER A 403 21.665 51.666 53.224 15.19 AKT3 C
ATOM 1996 O SER A 403 21.520 52.721 52.601 14.15 AKT3 O
ATOM 1997 N PHE A 404 22.040 50.536 52.631 15.14 AKT3 N
ATOM 1998 CA PHE A 404 22.248 50.505 51.192 14.25 AKT3 C
ATOM 1999 CB PHE A 404 22.836 49.166 50.755 14.75 AKT3 C
ATOM 2000 CG PHE A 404 23.136 49.087 49.276 13.79 AKT3 C
ATOM 2001 CDl PHE A 404 24.234 49.744 48.739 14.54 AKT3 C
ATOM 2002 CD2 PHE A 404 22.304 48.379 48.424 12.94 AKT3 C
ATOM 2003 CEl PHE A 404 24.491 49.695 47.374 15.06 AKT3 C
ATOM 2004 CE2 PHE A 404 22.556 48.330 47.066 13.28 AKT3 C
ATOM 2005 CZ PHE A 404 23.646 48.985 46.539 12.18 AKT3 C
ATOM 2006 C PHE A 404 20.899 50.719 50.509 14.41 AKT3 C
ATOM 2007 O PHE A 404 20.834 51.124 49.369 15.92 AKT3 O
ATOM 2008 N PHE A 405 19.817 50.451 51.221 16.23 AKT3 N
ATOM 2009 CA PHE A 405 18.476 50.626 50.670 17.66 AKT3 C
ATOM 2010 CB PHE A 405 17.683 49.323 50.779 15.55 AKT3 C
ATOM 2011 CG PHE A 405 18.235 48.216 49.944 16.31 AKT3 C
ATOM 2012 CDl PHE A 405 18.177 48.281 48.556 17.83 AKT3 C
ATOM 2013 CD2 PHE A 405 18.812 47.107 50.534 16.19 AKT3 C
ATOM 2014 CEl PHE A 405 18.682 47.259 47.774 18.04 AKT3 C
ATOM 2015 CE2 PHE A 405 19.321 46.076 49.757 17.15 AKT3 C
ATOM 2016 CZ PHE A 405 19.256 46.152 48.375 17.24 AKT3 C
ATOM 2017 C PHE A 405 17.722 51.722 51.402 18.80 AKT3 C
ATOM 2018 O PHE A 405 16.498 51.811 51.302 20.38 AKT3 O
ATOM 2019 N SER A 406 18.456 52.560 52.125 18.83 AKT3 N
ATOM 2020 CA SER A 406 17.847 53.631 52.905 19.26 AKT3 C
ATOM 2021 CB SER A 406 18.922 54.434 53.644 18.10 AKT3 C
ATOM 2022 OG SER A 406 19.572 55.341 52.775 14.87 AKT3 O
ATOM 2023 C SER A 406 16.974 54.589 52.104 20.12 AKT3 C
ATOM 2024 O SER A 406 16.303 55.437 52.679 22.64 AKT3 O
ATOM 2025 N GLY A 407 16.973 54.474 50.787 19.27 AKT3 N
ATOM 2026 CA GLY A 407 16.138 55.371 50.013 18.31 AKT3 C
ATOM 2027 C GLY A 407 15.018 54.649 49.280 18.49 AKT3 C
ATOM 2028 O GLY A 407 14.264 55.268 48.530 1.00 18.41 AKT3 O 004/026569
ATOM 2029 N VAL A 408 14.891 53.346 49.513 1.00 16.60 AKT3 N
ATOM 2030 CA VAL A 408 13.884 52.544 48.830 1.00 17.42 AKT3 C
ATOM 2031 CB VAIi A 408 14.428 51.117 48.569 1.00 17.40 AKT3 C
ATOM 2032 CGl VAL A 408 13.336 50.225 48.017 ,00 15.74 AKT3 C
ATOM 2033 CG2 VAL A 408 15.605 51.183 47.607 .00 18.94 AKT3 C
ATOM 2034 C VAL A 408 12.498 52.409 49.466 .00 18.12 AKT3 C
ATOM 2035 O VAL A 408 12.369 52.054 50.639 .00 18.44 AKT3 O
ATOM 2036 N ASN A 409 11.462 52.689 48.673 ,00 18.20 AKT3 N
ATOM 2037 CA ASN A 409 10.078 52.548 49.131 .00 18.38 AKT3 C
ATOM 2038 CB ASN A 409 9.171 53.617 48.505 .00 17.83 AKT3 C
ATOM 2039 CG ASN A 409 7-756 53.581 49.064 ,00 16.13 AKT3 C
ATOM 2040 ODl ASN A 409 7.054 52.578 48.950 .00 17.41 AKT3 O
ATOM 2041 ND2 ASN A 409 7.337 54.676 49.668 .00 12.37 AKT3 N
ATOM 2042 C ASN A 409 - 9.676 51.160 48.651 .00 18.88 AKT3 C
ATOM 2043 O ASN A 409 9.475 50.933 47.456 .00 19.98 AKT3 O
ATOM 2044 N TRP A 410 9.564 50.228 49.585 .00 19.37 AKT3 N
ATOM 2045 CA TRP A 410 9.256 48.851 49.226 .00 18.62 AKT3 C
ATOM 2046 CB TRP A 410 9.537 47.931 50.418 .00 16.30 AKT3 C
ATOM 2047 CG TRP A 410 10.994 47.951 50.774 .00 14.31 AKT3 C
ATOM 2048 CD2 TRP A 410 12.041 47.214 50.130 .00 14.65 AKT3 C
ATOM 2049 CE2 TRP A 410 13.263 47.659 50.675 1.00 13.56 AKT3 C
ATOM 2050 CE3 TRP A 410 12.065 46.224 49.142 15.46 AKT3 C
ATOM 2051 CDl TRP A 410 11.607 48.780 51.667 13.42 AKT3 C
ATOM 2052 NEl TRP A 410 12.970 48.615 51.611 14.54 AKT3 N
ATOM 2053 CZ2 TRP A 410 14.491 47.153 50.265 13.47 AKT3 C
ATOM 2054 CZ3 TRP A 410 13.287 45.724 48.737 15.43 AKT3 C
ATOM 2055 CH2 TRP A 410 14.483 46.189 49.298 14.46 AKT3 C
ATOM 2056 C TRP A 410 7.888 48.574 48.624 19.41 AKT3 C
ATOM 2057 O TRP A 410 7.721 47.595 47.904 19.35 AKT3 O
ATOM 2058 N GLN A 411 6.906 49.424 48.890 19.55 AKT3 N
ATOM 2059 CA GLN A 411 5.606 49.183 48.285 19.36 AKT3 C
ATOM 2060 CB GLN A 411 4.545 50.093 48.912 19.81 AKT3 C
ATOM 2061 CG GLN A 411 3.112 49.750 48.526 23.08 AKT3 C C
ATOM 2062 CD GLN A 411 2.736 48.289 48.800 27.21 AKT3 C C
ATOM 2063 OEl GLN A 411 2.801 47.429 47.906 28.17 AKT3 O
ATOM 2064 NE2 GLN A 411 2.341 48.004 50.042 27.61 AKT3 N
ATOM 2065 C GLN A 411 5.738 49.432 46.766 18.04 AKT3 C
ATOM 2066 O GLN A 411 5.152 48.707 45.964 13.83 AKT3 O
ATOM 2067 K ASP A 412 6.522 50.443 46.382 17.16 AKT3 N
ATOM 2068 CA ASP A 412 6.731 50.736 44.962 18.78 AKT3 C
ATOM 2069 CB ASP A 412 7.438 52.078 44.755 18.55 AKT3 C
ATOM 2070 CG ASP A 412 6.533 53.261 44.990 22.15 AKT3 C C
ATOM 2071 ODl ASP A 412 5.345 53.192 44.616 24.78 AKT3 O O
ATOM 2072 OD2 ASP A 412 7.012 54.272 45.538 24.52 AKT3 O
ATOM 2073 C ASP A 412 7.564 49.643 44.290 18.80 AKT3 C
ATOM 2074 O ASP A 412 7.390 49.354 43.109 18.80 AKT3 O
ATOM 2075 N VAL A 413 8.489 49.051 45.037 19.78 AKT3 N
ATOM 2076 CA VAL A 413 9.308 47.987 44.478 19.98 AKT3 C
ATOM 2077 CB VAL A 413 10.205 47.364 45.564 19.40 AKT3 C
ATOM 2078 CGl VAL A 413 10.899 46.122 45.021 19.05 AKT3 C
ATOM 2079 CG2 VAL A 413 11.238 48.395 46.031 21.11 AKT3 C
ATOM 2080 C VAL A 413 8.370 46.922 43.905 20.06 AKT3 C
ATOM 2081 O VAL A 413 8.434 46.577 42.721 19.13 AKT3 O
ATOM 2082 N TYR A 414 7.487 46.436 44.769 19.37 AKT3 N
ATOM 2083 CA TYR A 414 6.500 45.419 44.440 20.35 AKT3 C
ATOM 2084 CB TYR A 414 5.702 45.077 45.689 20.20 AKT3 C
ATOM 2085 CG TYR A 414 4.687 44.003 45.462 20.67 AKT3 C
ATOM 2086 CDl TYR A 414 5.013 42.663 45.641 20.02 AKT3 C
ATOM 2087 CEl TYR A 414 4.094 41.670 45.404 19.28 AKT3 C
ATOM 2088 CD2 TYR A 414 3.411 44.322 45.039 18.99 AKT3 C
ATOM 2089 CE2 TYR A 414 2.490 43.347 44.799 20.56 AKT3 C
ATOM 2090 CZ TYR A 414 2.830 42.017 44.981 21.12 AKT3 C
ATOM 2091 OH TYR A 414 1.891 41.040 44.729 21.76 AKT3 O
ATOM 2092 C TYR A 414 5.529 45.849 43.342 20.26 AKT3 C
ATOM 2093 O TYR A 414 5.174 45.056 42.473 20.69 AKT3 O
ATOM 2094 N ASP A 415 5.097 47.104 43.393 20.37 AKT3 N
ATOM 2095 CA ASP A 415 4.168 47.637 42.408 21.16 AKT3 C
ATOM 2096 CB ASP A 415 3.395 48.816 43.009 19.76 AKT3 C
ATOM 2097 CG ASP A 415 2.679 48.449 44.311 20.09 AKT3 C
ATOM 2098 ODl ASP A 415 2.186 47.305 44.428 18.20 AKT3 O
ATOM 2099 OD2 ASP A 415 2.597 49.307 45.212 19.51 AKT3 O
ATOM 2100 C ASP A 415 4.880 48.065 41.123 22.88 AKT3 C
ATOM 2101 O ASP A 415 4.338 48.818 40.322 1.00 24.62 AKT3 O US2004/026569
ATOM 2102 N LYS A 416 6.096 47.571 40.931 1.00 23.49 AK.T3 N
ATOM 2103 CA LYS A 416 6.892 47.883 39.751 1.00 24.86 AKT3 C
ATOM 2104 CB LYS A 416 6.412 47.043 38.559 1.00 25.51 AKT3 C
ATOM 2105 CG LYS A 416 6.352 45.539 38.852 1.00 26.32 AKT3 C
ATOM 2106 CD LYS A 416 6.507 44.697 37.587 1.00 27.35 AKT3 C
ATOM 2107 CE LYS A 416 5.347 44.890 36.630 1.00 28.73 AKT3 C
ATOM 2108 N2 LYS A 416 5.639 44.318 35.280 1.00 28.84 AKT3 N
ATOM 2109 C LYS A 416 6.872 49.364 39.390 1.00 25.32 AKT3 C
ATOM 2110 O LYS A 416 6.841 49.727 38.214 1.00 25.72 AKT3 O
ATOM 2111 N LYS A 417 6.902 50.219 40.407 1.00 25.99 AKT3 N
ATOM 2112 CA LYS A 417 6.894 51.655 40.191 1.00 26.10 AKT3 C
ATOM 2113 CB LYS A 417 6.077 52.356 41.272 1.00 27.74 AKT3 C
ATOM 2114 CG LYS A 417 4.581 52.202 41.110 1.00 28'.96 AKT3 C
ATOM 2115 CD LYS A 417 3.856 53.270 41.891 1.00 30.72 AKT3 C
ATOM 2116 CE LYS A 417 2.359 53.238 41.636 1.00 34.86 AKT3 C
ATOM 2117 NZ LYS A 417 2.027 53.514 40.199 1.00 36.81 AKT3 N
ATOM 2118 C LYS A 417 8.278 52.295 40.120 1.00 26.47 AKT3 C
ATOM 2119 O LYS A 417 8.407 53.429 39.676 1.00 27.09 AKT3 O
ATOM 2120 N LEU A 418 9.314 51.598 40.567 1.00 25.71 AKT3 N
ATOM 2121 CA LEU A 418 10.643 52.187 40.479 1.00 25.17 AKT3 C
ATOM 2122 CB LEU A 418 11.664 51.431 41.337 1.00 25.41 AKT3 C
ATOM 2123 CG LEU A 418 11.428 51.424 42.846 1.00 26.09 AKT3 C
ATOM 2124 CDl LEU A 418 11.171 52.842 43.332 1.00 27.62 , AKT3 C
ATOM 2125 CD2 LEU A 418 10.228 50.546 43.165 1.00 28.34 AKT3 C
ATOM 2126 C LEU A 418 11.063 52.124 39.021 1.00 25.24 AKT3 C
ATOM 2127 O LEU A 418 10.944 51.084 38.373 1.00 25.42 AKT3 O
ATOM 2128 N VAL A 419 11.535 53.247 38.501 1.00 24.02 AKT3 N
ATOM 2129 CA VAL A 419 11.968 53.309 37.120 1.00 23.18 AKT3 C
ATOM 2130 CB VAL A 419 12.237 54.755 36.704 1.00 24.48 AKT3 C
ATOM 2131 CGl VAL A 419 12.783 54.786 35.293 1.00 24.86 AKT3 C
ATOM 2132 CG2 VAL A 419 10.944 55.563 36.795 1.00 23.15 AKT3 C
ATOM 2133 C VAL A 419 13.238 52.497 36.927 1.00 22.78 AKT3 C
ATOM 2134 O VAL A 419 14.255 52.765 37.563 1.00 21.25 AKT3 O
ATOM 2135 N PRO A 420 13.190 51.477 36.055 1.00 22.59 AKT3 N
ATOM 2136 CD PRO A 420 11.993 50.938 35.387 1.00 21.68 AKT3 C
ATOM 2137 CA PRO A 420 14.360 50.632 35.794 1.00 22.63 AKT3 C
ATOM 2138 CB PRO A 420 13.829 49.606 34.795 1.00 22.32 AKT3 C
ATOM 2139 CG PRO A 420 12.372 49.490 35.178 1.00 20.94 AKT3 C
ATOM 2140 C PRO A 420 15.538 51.443 35.242 1.00 23.57 AKT3 C
ATOM 2141 O PRO A 420 15.356 52.384 34.474 1.00 22.34 AKT3 O
ATOM 2142 N PRO A 421 16.765 51.095 35.656 1.00 24.85 AKT3 N
ATOM 2143 CD PRO A 421 17.052 50.197 36.788 1.00 24.46 . AKT3 C
ATOM 2144 CA PRO A 421 17.983 51.784 35.212 1.00 25.55 AKT3 C
ATOM 2145 CB PRO A 421 19.054 51.237 36.156 1.00 27.18 ■AKT3 C
ATOM 2146 CG PRO A 421 18.257 50.852 37.395 1.00 27.21 AKT3 C
ATOM 2147 C PRO A 421 18.314 51.505 33.749 1.00 25.75 AKT3 C
ATOM 2148 O PRO A 421 18.969 52.311 33.092 1.00 25.62 AKT3 O
ATOM 2149 N PHE A 422 17.848 50.360 33.249 1.00 24.97 AKT3 N
ATOM 2150 CA PHE A 422 18.085 49.949 31.870 1.00 23.16 AKT3 C
ATOM 2151 CB PHE A 422 19.102 48.805 31.835 1.00 23.58 AKT3 C
ATOM , 2152 CG PHE A 422 19.204 48.117 30.501 1.00 23.47 AKT3 C
ATOM 2153 CDl PHE A 422 19.725 48.773 29.400 1.00 23.21 AKT3 C
ATOM 2154 CD2 PHE A 422 18.787 46.810 30.352 1.00 23.91 AKT3 C
ATOM 2155 CEl PHE A 422 19.833 48.142 28.185 1.00 22.29 AKT3 C
ATOM 2156 CE2 PHE A 422 18.892 46.175 29.133 1.00 25.15 AKT3 C
ATOM 2157 CZ PHE A 422 19.418 46.845 28.048 1.00 23.40 AKT3 C
ATOM 2158 C PHE A 422 16.787 49.492 31.233 1.00 22.77 AKT3 C
ATOM 2159 O PHE A 422 16.047 48.702 31.811 1.00 23.02 AKT3 O
ATOM 2160 N LYS A 423 16.515 49.979 30.032 1.00 23.98 AKT3 N
ATOM 2161 CA LYS A 423 15.292 49.614 29.334 1.00 24.95 AKT3 C
ATOM 2162 CB LYS A 423 14.518 50.878 28.927 1.00 24.61 AKT3 C
ATOM 2163 CG LYS A 423 13.352 50.623 27.941 1.00 28.47 AKT3 C
ATOM 2164 CD LYS A 423 12.364 49.558 28.470 1.00 27.67 AKT3 C
ATOM 2165 CE LYS A 423 11.215 49.258 27.491 1.00 27.77 AKT3 C
ATOM 2166 NZ LYS A 423 11.576 48.366 26.336 1.00 26.13 AKT3 N
ATOM 2167 C LYS A 423 15.572 48.771 28.103 1.00 25.78 AKT3 C
ATOM 2168 O LYS A 423 16.152 49.255 27.141 1.00 26.12 AKT3 O
ATOM 2169 N PRO A 424 15.179 47.487 28.126 1.00 27.04 AKT3 N
ATOM 2170 CD PRO A 424 14.597 46.726 29.243 1.00 27.40 AKT3 C
ATOM 2171 CA PRO A 424 15.407 46.617 26.970 1.00 27.39 AKT3 C
ATOM 2172 CB PRO A 424 14.675 45.337 27.360 1.00 27.89 AKT3 C
ATOM 2173 CG PRO A 424 14.889 45.292 28.845 1.00 27.42 AKT3 C
ATOM 2174 C PRO A 424 14.797 47.297 25.749 1.00 27.97 AKT3 C 4 026569
ATOM 2175 O PRO A 424 13.657 47.750 25.787 1.00 27.28 AKT3 O
ATOM 2176 N GLN A 425 15.557 47.370 24.667 1.00 28.82 AKT3 N
ATOM 2177 CA GLN A 425 15.077 48.038 23.465 1.00 30.45 AKT3 C
ATOM 2178 CB GLN A 425 16.252 48.752 22.781 1.00 31.64 AKT3 C
ATOM 2179 CG GLN A 425 16.824 49.909 23.581 1.00 32.33 AKT3 C
ATOM 2180 CD GLN A 425 15.728 50.844 24.097 1.00 36.59 AKT3 C
ATOM 2181 OEl GLN A 425 14.750 51.132 23.389 1.00 36.34 AKT3 O
ATOM 2182 NE2 GLN A 425 15.890 51.330 25.335 1.00 36.96 AKT3 N
ATOM 2183 C GLN A 425 14.353 47.124 22.469 1.00 30.55 AKT3 C
ATOM 2184 O GLN A 425 14.760 47.005 21.311 1.00 31.78 AKT3 O
ATOM 2185 N VAL A 425 13.272 46.496 22.922 1.00 29.84 AKT3 N
ATOM 2186 CA VAL A 426 12.502 45.588 22.083 1.00 30.44 AKT3 C
ATOM 2187 CB VAL A 426 11.943 44.423 22.925 1.00 30.03 AKT3 C
ATOM 2188 CGl VAL A 426 13.099 43.633 23.531 1.00 29.17 AKT3 C
ATOM 2189 CG2 VAL A 426 11.038 44.952 24.024 1.00 29.14 AKT3 C
ATOM 2190 C VAL A 426 11.366 46.311 21.361 1.00 31.55 AKT3 C
ATOM 2191 O VAL A 426 10.709 47.174 21.929 1.00 31.80 AKT3 O
ATOM 2192 H THR A 427 11.143 45.955 20.101 1.00 32.79 AKT3 N
ATOM 2193 CA THR A 427 10.112 46.604 19.296 1.00 34.05 AKT3 C
ATOM 2194 CB THR A 427 10.538 46.654 17.808 1.00 34.35 AKT3 C
ATOM 2195 OGl THR A 427 10.390 45.357 17.217 1.00 34.19 AKT3 O
ATOM 2196 CG2 THR A 427 12.014 47.081 17.694 1.00 34.08 AKT3 C
ATOM 2197 C THR A 427 8.734 45.956 19.392 1.00 35.55 AKT3 ,c
ATOM 2198 O THR A 427 7.715 46.577 19.075 1.00 37.15 AKT3 O
ATOM 2199 N SER A 428 8.690 44.707 19.829 1.00 36.35 AKT3 N
ATOM ' 2200 CA SER A 428 7.415 44.018 19.948 1.00 36.44 AKT3 C
ATOM 2201 CB SER A 428 7.048 43.332 18.628 1.00 35.82 AKT3 C
ATOM 2202 OG SER A 428 8.039 42.392 18.247 1.00 33.51 AKT3 O
ATOM 2203 C SER A 428 7.532 42.985 21.035 1.00 37.20 AKT3 C
ATOM 2204 O SER A 428 8.603 42.409 21.233 1.00 38.77 AKT3 O
ATOM 2205 N GLU A 429 6.431 42.753 21.739 1.00 37.81 AKT3 N
ATOM 2206 CA GLU A 429 6.399 41.771 22.817 1.00 38.46 AKT3 C
ATOM 2207 CB GLU A 429 4.980 41.625 23.348 1.00 39.32 AKT3 C
ATOM 2208 CG GLU A 429 4.042 40.973 22.352 1.00 39.80 AKT3 C
ATOM 2209 CD GLU A 429 2.662 40.766 22.933 1.00 40.94 AKT3 C
ATOM 2210 OEl GLU A 429 2.044 41.775 23.345 1.00 43.72 AKT3 O
ATOM 2211 0E2 GLU A 429 2.196 39.607 22.984 1.00 40.49 AKT3 O
ATOM 2212 C GLU A 429 6.872 40.418 22.289 1.00 37.73 AKT3 C
ATOM 2213 O GLU A 429 6.916 39.425 23.020 1.00 37.56 AKT3 O
ATOM 2214 N THR A 430 7.218 40.391 21.009 1.00 35.91 AKT3 N
ATOM 2215 CA THR A 430 7.678 39.175 20.374 1.00 33.83 AKT3 C
ATOM 2216 CB THR A 430 6.764 38.823 19.163 1.00 35.66 AKT3 C
ATOM 2217 OGl THR A 430 5.980 37.666 19.479 1.00 35.18 AKT3 O
ATOM 2218 CG2 THR A 430 7.590 38.557 17.896 1.00 35.70 AKT3 C
ATOM 2219 C THR A 430 9.120 39.335 19.911 1.00 31.93 AKT3 C
ATOM 2220 O THR A 430 9.764 38.353 19.539 1.00 30.96 AKT3 O
ATOM 2221 N ASP A 431 9.626 40.567 19.962 1.00 29.72 AKT3 N
ATOM 2222 CA ASP A 431 10.985 40.867 19.514 1.00 29.32 AKT3 C
ATOM 2223 CB ASP A 431 11.615 41.953 20.384 1.00 27.77 AKT3 C
ATOM 2224 CG ASP A 431 12.782 42.640 19.691 1.00 26.82 AKT3 C
ATOM 2225 ODl ASP A 431 12.698 43.861 19.424 1.00 25.64 AKT3 O
ATOM 2226 OD2 ASP A 431 13.781 41.952 19.406 1.00 24.92 AKT3 O
ATOM 2227 C ASP A 431 11.894 39.633 19.461 1.00 29.27 AKT3 C
ATOM 2228 O ASP A 431 11.771 38.830 18.538 1.00 32.17 AKT3 O
ATOM 2229 N THR A 432 12.810 39.489 20.418 1.00 27.66 AKT3 N
ATOM 2230 CA THR A 432 13.726 38.335 20.479 1.00 25.92 AKT3 C
ATOM 2231 CB THR A 432 13.331 37.245 19.445 1.00 25.35 AKT3 C
ATOM 2232 OGl THR A 432 12.100 36.634 19.850 1.00 27.60 AKT3 O
ATOM 2233 CG2 THR A 432 14.392 36.172 19.338 1.O0 25.87 AKT3 C
ATOM 2234 C THR A 432 15.214 38.659 20.309 1.00 25.49 AKT3 C
ATOM 2235 O THR A 432 16.074 37.837 20.649 1.00 24.71 AKT3 O
ATOM 2236 N ARG A 433 15.523 39.853 19.809 1.00 24.00 AKT3 N
ATOM 2237 CA ARG A 433 16.912 40.250 19.605 1.00 25.04 AKT3 C
ATOM 2238 CB ARG A 433 17.018 41.756 19.378 1.00 27.14 AKT3 C
ATOM 2239 CG ARG A 433 17.240 42.575 20.646 1.00 29.92 AKT3 C
ATOM 2240 CD ARG A 433 15.946 43.176 21.148 1.00 32.14 AKT3 C
ATOM 2241 NE ARG A 433 15.251 43.855 20.060 1.00 34.82 AKT3 N
ATOM 2242 CZ ARG A 433 15.805 44.781 19.280 1.00 36.00 AKT3 C
ATOM 2243 NHl ARG A 433 17.071 45.141 19.477 1.00 36.68 AKT3 N
ATOM 2244 NH2 ARG A 433 15.102 45.328 18.290 1.00 34.50 AKT3 N
ATOM 2245 C ARG A 433 17.849 39.874 20.752 1.00 24.30 AKT3 C
ATOM 2246 O ARG A 433 18.998 39.510 20.524 1.00 24.44 AKT3 O
ATOM 2247 N TYR A 434 17.371 39.957 21.985 1.00 24.67 AKT3 N ATOM 2248 CA TYR A 434 18.229 39.631 23.109 1.00 24.51 AKT3 C
ATOM 2249 CB TYR A 434 17.588 40.082 24.413 1.00 21.36 AKT3 C
ATOM 22B0 CG TYR A 434 17.603 41.579 24.518 .00 19.61 AKT3 C
ATOM 2251 CDl TYR A 434 18.803 42.276 24.492 .00 18.55 AKT3 C
ATOM 2252 CEl TYR A 434 18.829 43.650 24.513 .00 18.76 AKT3 C
ATOM 2253 CD2 TYR A 434 16.426 42.303 24.574 .00 18.49 AKT3 C
ATOM 2254 CE2 TYR A 434 16.440 43.674 24.597 .00 19.43 AKT3 C
ATOM 2255 CZ TYR A 434 17.644 44.345 24.565 .00 19.67 AKT3 C
ATOM 2256 OH TYR A 434 17.659 45.718 24.581 .00 24.11 AKT3 O
ATOM 2257 C TYR A 434 18.634 38.177 23.180 .00 25.80 AKT3 C
ATOM 2258 O TYR A 434 19.503 37.810 23.966 .00 26.70 AKT3 O
ATOM 2259 N PHE A 435 18.022 37.346 22.350 .00 27.27 AKT3 N
ATOM 2260 CA PHE A 435 18.378 35.934 22.328 .00 28.99 AKT3
ATOM 2261 CB PHE A 435 17.120 35.084 22.507 .00 26.46 AKT3
ATOM 2262 CG PHE A 435 16.332 35.459 23.728 1.00 25.45 AKT3
ATOM 2263 CDl PHE A 435 15.163 36.189 23.621 1.00 24.55 AKT3
ATOM 2264 CD2 PHE A 435 16.811 35.162 24.994 1.00 ,24.50 AKT3
ATOM 2265 CEl PHE A 435 14.492 36.619 24.751 1.00 23.44 AKT3
ATOM 2266 CE2 PHE A 435 16.143 35.590 26.122 1.00 22.49 AKT3 C
ATOM 2267 CZ PHE A 435 14.983 36.320 26.001 22.71 AKT3 C
ATOM 2268 C PHE A 435 19.103 35.635 21.016 30.49 AKT3 C
ATOM 2269 O PHE A 435 19.776 34.615 20.879 29.96 AKT3 O
ATOM 2270 N ASP A 436 18.977 36.570 20.076 33.74 AKT3 N
ATOM 2271 CA ASP A 436 19.610 36.475 18.772 36.76 AKT3 C
ATOM 2272 CB ASP A 436 18.861 37.318 17.731 37.08 AKT3 C
ATOM 2273 CG ASP A 436 17.413 36.891 17.553 38.85 AKT3 C
ATOM 2274 ODl ASP A 436 17.120 35.688 17.719 1.00 39.77 AKT3 O
ATOM 2275 OD2 ASP A 436 16.566 37.755 17.225 .00 39.25 AKT3 O
ATOM 2276 C ASP A 436 21.053 36.966 18.837 .00 40.29 AKT3 C
ATOM 2277 O ASP A 436 21.869 36.397 19.556 .00 40.17 AKT3 O
ATOM 2278 N ASP A 437 21.338 38.038 18.084 .00 44.98 AKT3 N
ATOM 2279 CA ASP A 437 22.675 38.648 17.965 .00 47.25 AKT3 C
ATOM 2280 CB ASP A 437 22.842 39.814 18.946 .00 48.23 AKT3 C
ATOM 2281 CG ASP A 437 22.395 39.464 20.355 .00 48.38 AKT3 C
ATOM 2282 ODl ASP A 437 22.779 38.389 20.862 .00 48.63 AKT3 O
ATOM 2283 OD2 ASP A 437 21.663 40.280 20.957 .00 48.80 AKT3 O
ATOM 2284 C ASP A 437 23.771 37.626 18.199 .00 48.62 AKT3 C
ATOM 2285 O ASP A 437 24.502 37.700 19.202 .00 49.08 AKT3 O
ATOM 2286 N GLU A 438 23.883 36.683 17.259 .00 49.69 AKT3 N
ATOM 2287 CA GLU A 438 24.857 35.592 17.336 .00 50.31 AKT3 C
ATOM 2288 CB GLU A 438 26.294 36.134 17.287 .00 50.02 AKT3 C
ATOM 2289 CG GLU A 438 26.763 36.808 18.574 .00 50.57 AKT3 C
ATOM 2290 CD GLU A 438 27.277 35.819 19.616 .00 50.12 AKT3 C
ATOM 2291 OEl GLU A 438 27.439 36.224 20.794 .00 49.28 AKT3 O
ATOM 2292 OE2 GLU A 438 27.530 34.647 19.251 .00 49.76 AKT3 O
ATOM 2293 C GLU A 438 24.607 34.874 18.663 .00 50.94 AKT3 C
ATOM 2294 O GLU A 438 23.906 35.405 19.525 .00 51.47 AKT3 O
ATOM 2295 N ALA A 439 25.166 33.675 18.825 .00 51.46 AKT3 N
ATOM 2296 CA ALA A 439 24.995 32.897 20.056 .00 51.47 AKT3 C
ATOM 2297 CB ALA A 439 26.357 32.329 20.512 .00 51.06 AKT3 C
ATOM 2298 C ALA A 439 24.376 33.742 21.177 1.00 51.31 AKT3 C
ATOM 2299 O ALA A 439 23.143 33.898 21.265 1.00 51.43 AKT3 O
ATOM 2300 N ALA A 440 25.249 34.284 22.025 .00 50.22 AKT3 N
ATOM 2301 CA ALA A 440 24.847 35.126 23.137 .00 48.91 AKT3 C
ATOM 2302 CB ALA A 440 26.083 35.607 23.874 .00 49.74 AKT3 C
ATOM 2303 C ALA A 440 24.041 36.317 22.624 .00 47.86 AKT3 C
ATOM 2304 O ALA A 440 24.459 37.471 22.874 .00 47.38 AKT3 O
ATOM 2305 OXT ALA A 440 23.002 36.077 21.978 .00 46.51 AKT3 O
ATOM 2306 CL4 INH 1 15.362 23.774 28.423 .00 11.12 CL
ATOM 2307 CL2 INH 1 19.211 27.156 26.562 .00 11.07 CL
ATOM 2308 Cl INH 1 13.044 33.763 26.723 .00 26.41 C
ATOM 2309 Sl INH 1 16.472 31.027 28.571 .00 31.18 S
ATOM 2310 C2 INH 1 14.173 32.976 27.123 .00 26.94 C
ATOM 2311 C3 INH 1 13.966 32.286 28.303 .00 27.07 C
ATOM 2312 N4 INH 1 12.802 32.359 28.995 .00 26.30 N
ATOM 2313 C5 INH 1 11.814 33.105 28.563 .00 26.03 C
ATOM 2314 N6 INH 1 11.862 33.839 27.434 1.00 27.01 N
ATOM 2315 N9 INH 1 10.711 33.104 29.335 1.00 26.73 N
ATOM 2316 ClO INH 1 10.663 32.303 30.565 1.00 23.84 C
ATOM 2317 C15 INH 1 14.899 31.417 29.003 1.00 28.32 C
ATOM 2318 C16 INH 1 14.596 30.816 30.122 1.00 29.79 C
ATOM 2319 Cl7 INH 1 15.632 30.031 30.656 1.00 29.83 C
ATOM 2320 C18 INH 1 16.794 30.023 29.920 1.00 29.74 C ATOM 2321 C22 INH 1 17.885 29.283 30.364 1.00 29.73 C
ATOM 2322 023 INH 1 17.726 28.659 31.422 1.00 34.03 O
ATOM 2323 N24 INH 1 19.047 29.224 29.733 1.00 27.74 N
ATOM 2324 C25 INH 1 20.092 28.413 30.323 1.00 24.29 C
ATOM 2325 C27 INH 1 21.349 29.231 30.564 .00 24.78 C
ATOM 2326 C28 INH 1 20.325 27.206 29.427 .00 22.48 C
ATOM 2327 C30 INH 1 19.087 26.351 29.127 .00 18.61 C
ATOM 2328 C33 INH 1 18.514 26.275 27.855 .00 16.68 C
ATOM 2329 C34 INH 1 17.358 25.484 27.596 .00 15.94 C
ATOM 2330 C35 INH 1 16.117 24.754 28.675 .00 16.33 C
ATOM 2331 C36 INH 1 17.337 24.812 29.974 .00 15.71 C
ATOM 2332 C37 INH 1 18.482 25.607 30.186 .00 15.21 C
ATOM 2333 N43 INH 1 21.031 30.082 31.689 1.00 23.48 N
ATOM 2334 O HOH W 1 17.025 51.022 54.161 1.00 5.71 W O
ATOM 2335 O HOH W 2 20.956 35.256 33.342 11.26 W O
ATOM 2336 O HOH W 3 5.114 34.235 39.714 16.12 W O
ATOM 2337 O HOH W 4 28.391 46.346 57.564 25.35 W O
ATOM 2338 O HOH W 5 16.604 47.052 33.920 5.62 W O
ATOM 2339 O HOH W 6 14.754 39.926 23.097 12.03 W O
ATOM 2340 O HOH W 7 13.291 25.148 46.499 21.27 W O
ATOM 2341 O HOH W 8 10.509 30.852 37.385 18.96 W O
ATOM 2342 O HOH W 9 23.450 53.424 50.141 8.89 W O
ATOM 2343 O HOH W 10 6.801 40.461 48.447 20.14 W O
ATOM 2344 O HOH W 11 19.031 31.134 46.601 11.55 W O
ATOM 2345 O HOH W 12 14.222 28.213 56.756 1.00 25.48 W O
ATOM 2346 O HOH W 13 28.207 33.492 37.051 22.83 W O
ATOM 2347 O HOH W 14 20.076 37.057 26.378 18.13 W O
ATOM 2348 O HOH W 15 25.503 52.861 46.560 27.89 W O
ATOM 2349 O HOH W 16 12.622 31.498 60.783 34.68 W O
ATOM 2350 O HOH W 17 23.688 40.361 60.041 42.21 W O
ATOM 2351 O HOH W 18 16.341 29.406 38.424 29.08 W O
ATOM 2352 O HOH W 19 22.248 49.551 57.855 19.77 W O
ATOM 2353 O HOH W 20 28.964 30.639 47.661 28.50 W O
ATOM 2354 O HOH W 21 42.942 48.370 51.024 42.83 W O
ATOM 2355 O HOH W 22 6.785 12.328 34.360 37.49 W O
ATOM 2356 O HOH W 23 14.815 54.260 54.629 19.39 W O
ATOM 2357 O HOH W 24 5.769 31.621 40.178 1.00 24.55 W O
ATOM 2358 O HOH W 25 295 55.229 44.912 .00 19.43 W O
ATOM 2359 O HOH W 26 18.108 53.731 48.599 .00 15.05 W O
ATOM 2360 O HOH W 27 24.481 20.268 55.671 .00 29.50 W O
ATOM 2361 O HOH W 28 -0.713 20.504 31.083 .00 15.37 W O
ATOM 2362' O HOH W 29 11.521 39.573 22.283 .00 35.51 W O
ATOM 2363 O HOH W 30 32.280 35.072 53.271 .00 31.37 W O
ATOM 2364 O HOH W 31 31.974 32.556 44.476 .00 33.86 W O
ATOM 2365 O HOH W 32 12.122 54.391 46.495 .00 22.05 W O
ATOM 2366 O HOH W 33 21.268 53.830 37.993 .00 35.55 W O
ATOM 2367 O HOH W 34 4.001 30.147 38.431 .00 24.91 W O
ATOM 2368 O HOH W 35 16.944 51.874 42.621 1.00 27.62 W O
ATOM 2369 O HOH W 36 19.909 34.457 26.187 1.0O 31.90 W O
ATOM 2370 O HOH W 37 29.501 49.001 40.793 1.00 22.52 W O
ATOM 2371 O HOH W 38 19.774 31.405 59.472 25.66 W O
ATOM 2372 O HOH W 39 39.890 36.159 54.118 26.48 W O
ATOM 2373 O HOH W 40 1.598 25.449 14.215 27.90 W O
ATOM 2374 O HOH W 41 1.580 39.201 18.379 27.26 W O
ATOM 2375 O HOH W 42 26.415 27.896 62.342 29.36 W O
ATOM 2376 O HOH W 43 38.959 50.608 54.603 27.97 W O
ATOM 2377 O HOH W 44 18.105 30.104 57.480 18.35 W O
ATOM 2378 O HOH W 45 9.751 40.313 15.840 34.92 W O
ATOM 2379 O HOH W 46 21.000 28.687 55.361 35.61 W O
ATOM 2380 O HOH W 47 22.027 46.226 29.755 29.35 W O
ATOM 2381 O HOH W 48 33.451 47.982 41.290 22.67 W O
ATOM 2382 O HOH W 49 -0.751 52.334 41.383 40.68 W O
ATOM 2383 O HOH W 50 1.715 43.978 24.913 39.02 W O
ATOM 2384 O HOH W 51 24.340 16.158 57.406 32.40 W O
ATOM 2385 O HOH W 52 11.878 33.866 58.559 28.56 W O
ATOM 2386 O HOH W 53 10.107 37.188 55.010 20.63 W O
ATOM 2387 O HOH W 54 33.826 36.728 55.101 35.26 W O
ATOM 2388 O HOH W 55 24.993 49.895 35.063 15.87 W O
ATOM 2389 O HOH W 56 20.640 22.625 38.132 29.30 W O
ATOM 2390 O HOH W 57 15.898 33.629 19.021 33.19 W O
ATOM 2391 O HOH W 58 13.338 26.739 42.964 33.28 W O
ATOM 2392 O HOH W 59 33.964 53.490 50.034 25.71 W O
ATOM 2393 O HOH W 60 25.609 31.089 65.428 1.00 32.62 W O ATOM 2394 O HOH W 61 7.425 47.662 16.464 1.00 29.50 W O
ATOM 2395 O HOH W 62 9.291 50.751 51.974 1.00 28.66 W O
ATOM 2396 O HOH W 63 9.817 39.219 58.691 1.00 34.57 W O
ATOM 2397 O HOH W 64 17.397 21.821 36.071 1.00 29.51 W O
ATOM 2398 O HOH W 65 26.833 19.190 35.732 1.00 42.31 W O
ATOM 2399 O HOH W 66 11.481 25.361 50.647 1.00 12.28 W O
ATOM 2400 O HOH W 67 12.784 20.766 49.369 1.00 24.51 W O
ATOM 2401 O HOH W 68 2.321 33.265 53.915 1.00 37.75 W O
ATOM 2402 O HOH W 69 10.057 42.692 50.497 1.00 32.17 W O
ATOM 2403 O HOH W 70 38.067 45.048 51.093 1.00 32.14 W O
ATOM 2404 O HOH W 71 17.979 16.273 42.377 1.00 22.30 W O
ATOM 2405 O HOH W 72 44.010 22.086 46.467 1.00 32.70 W 0
ATOM 2406 O HOH W 73 37.801 48.021 51.275 1.00 29.95 W O
ATOM 2407 O HOH W 74 23.540 18.367 40.346 1.00 35.35 W O
ATOM 2408 O HOH W 75 13.007 40.001 16.677 1.00 29.72 W O
ATOM 2409 O HOH W 76 19.615 33.947 63.378 1.00 28.04 W O
ATOM 2410 O HOH W 77 40.451 48.764 54.387 1.00 41.31 W O
ATOM 2411 O HOH W 78 28.264 52.905 40.602 1.00 23.41 W O
ATOM 2412 O HOH W 79 26.956 27.332 37.927 1.00 39.17 W O
ATOM 2413 O HOH W 80 38.137 34.686 46.471 1.00 28.84 W O
ATOM 2414 O HOH W 81 16.903 26.293 38.627 1.00 25.32 W O
ATOM 2415 O HOH W 82 27.474 18.908 61.532 1.00 40.51 W O
ATOM 2416 O HOH W 83 17.877 52.907 24.666 1.00 40.92 W O
ATOM 2417 O HOH W 84 1.238 15.538 31.751 1.00 28.49 W O
ATOM 2418 O HOH W 85 44.716 51.293 52.435 1.00 32.39 W O
ATOM 2419 O HOH W 86 1.455 22.327 16.762 1.00, 38.77 W O
ATOM 2420 O HOH W 87 10.012 34.669 63.209 1.00 29.66 W O
ATOM 2421 O HOH W 88 31.637 35.769 58.394 1.00 22.65 W O
ATOM 2422 O HOH W 89 9.810 48.722 40.295 1.00 33.32 W O
ATOM 2423 O HOH W 90 20.984 42.266 19.712 1.00 38.98 W O
ATOM 2424 O HOH W 91 19.184 23.665 43.942 1.00 23.49 W O
ATOM 2425 O HOH W 92 5.111 11.444 23.490 1.00 29.60 W O
ATOM 2426 O HOH W 93 14.176 28.713 15.524 1.00 30.95 W O
ATOM 2427 O HOH W 94 16.247 21.448 39.014 1.00 32.81 W O
ATOM 2428 O HOH W 95 44.298 25.721 42.305 1.00 22.17 W O
ATOM 2429 O HOH W 96 24.880 12,037 39.676 1.00 36.02 W O
ATOM 2430 O HOH W 97 17.078 31.720 33.039 1.00 28.38 W O
ATOM 2431 O HOH W 98 2.743 19.206 17.055 1.00 31.40 W O
ATOM 2432 O HOH W 99 25.353 53.880 41.291 1.00 20.65 W O
ATOM 2433 O HOH W 100 8.580 40.456 28.642 1.00 36.12 W O
ATOM 2434 O HOH W 101 22.339 34.010 30.638 1.00 34.75 W O
ATOM 2435 O HOH W 102 16.652 23.732 37.652 1.00 33.85 W O
ATOM 2436 O HOH W 103 14.943 38.181 29.429 1.00 38.38 W O
ATOM 2437 O HOH W 104 5.718 11.431 31.419 1.00 31.59 W O
ATOM 2438 O HOH W 105 7.537 40.142 25.343 1.00 24.71 W O
ATOM 2439 O HOH W 106 10.819 47.723 59.078 1.00 33.82 W O
ATOM 2440 O HOH W 107 6.568 40.819 33.838 1.00 43.47 W O
ATOM 2441 O HOH W 108 11.833 51.125 30.989 1.00 27.61 W O
ATOM 2442 O HOH W 109 3.647 49.838 37.476 1.00 40.05 W O
ATOM 2443 O HOH W 110 28.063 37.388 33.839 1.00 45.21 W O
END
US2004/026569
Table 5. Atomic Coordinates of Akt3 (T305D and S472D) Mutant complexed to N-[(lS)-2-amino-l-(2,4-dichlorobeBzyl)ethyl]-5-[2-(methylamino)pyrimidin-4- yl] thiophene-2-carb oxamide.
REMARK refinement resolution: 30.0 - 2-35 A
REMARK starting r= 0.2797 free_r= 0.3444
REMARK final r= 0.2499 free_r= 0.3023
REMARK sg= P2 (1)2 (1)2(1) a= 48.105 b= 73.526 C= 95.846 alphas 90 beta= 90 gamma= 90
REMARK theoretical total number of refl • in resol. range 14736 ( 100.0 % )
REMARK number of unobserved reflections (no entry or |F| =0): 541 ( 3.7 % )
REMARK number of reflections rejected: 0 ( 0.0 % )
REMARK total number of reflections used.: 14195 ( 96.3 % )
REMARK number of reflections in working set: 13492 ( 91.6 % )
REMARK number of reflections in test set 703 ( 4.8 % )
REMARK
ATOM 1 CB LYS 143 49.130 15.085 75.193 1.00 46.67 C
ATOM 2 CG LYS 143 49.987 14.106 75.959 1.00 47.64 C
ATOM 3 CD LYS 143 51.214 13.704 75.170 1.00 48.12 C
ATOM 4 CE LYS 143 52.226 13.034 76.080 1.00 48.57 C
ATOM 5 NS LYS 143 53.517 12.780 75.383 1.00 49.59 N
ATOM 6 C LYS 143 48.824 17.354 74.213 1.00 46.08 C
ATOM 7 O LYS 143 48.342 18.288 74.859 1.00 45.58 O
ATOM 8 N LYS 143 50.382 17.008 7S.125 1.00 46.82 N
ATOM 9 CA LYS 143 49.825 16.404 74.872 1.00 46.53 C
ATOM 10 N THR 144 48.517 17.092 72.936 1.00 46.14 N
ATOM 11 CA THR 144 47.584 17.893 72.122 1.00 45.39 C
ATOM 12 CB THR 144 48.370 18.877 71.257 1.00 45.98 C
ATOM 13 OGl THR 144 47.467 19.780 70.608 1.00 49.02 O
ATOM 14 CG2 THR 144 49.167 18.122 70.208 1.00 45.29 C
ATOM 15 C THR 144 4S.797 16.948 71.188 1.00 45.01 C
ATOM 16 O THR 144 47.027 15.747 71.218 1.00 44.05 O
ATOM 17 N MET 145 45.883 17.458 70.357 1.00 45.12 N
ATOM 18 CA MET 145 45.130 16.556 69.465 1.00 45.56 C
ATOM 19 CB MET 145 44.161 17.323 68.563 1.00 47.90 C
ATOM 20 CG MET 145 43.042 18.059 69.302 1.00 50.22 C
ATOM 21 SD MET 145 42.112 16.994 70.449 1.00 54.12 S
ATOM 22 CE MET 145 41.932 15.472 69.447 1.00 52.10 C
ATOM 23 C MET 145 46.106 15.762 68.602 1.00 45.52 C
ATOM 24 O MET 145 45.840 14.613 68.237 1.00 44.54 O
ATOM 25 N ASN 146 47.223 16.392 68.247 1.00 45.73 N
ATOM 26 CA ASN 146 48.253 15.705 67.493 1.00 44.96 C
ATOM 27 CB ASN 146 49.353 16.680 67.055 1.00 46.21 C
ATOM 28 CG ASN 146 48.917 17.556 65.900 1.00 46.78 C
ATOM 29 ODl ASN 146 47.788 18.065 65.881 1.00 48.08 O
ATOM 30 ND2 ASN 146 49.812 17.747 64.928 1.00 45.64 N
ATOM 31 C ASN 146 48.803 14.771 68.560 1.00 45.08 C
ATOM 32 O ASN 146 48.427 14.884 69.728 1.00 45.59 O
ATOM 33 N ASP 147 49.707 13.876 68.195 1.00 44.51 N
ATOM 34 CA ASP 147 50.228 12.908 69.166 1.00 42.87 C
ATOM 35 CB ASP 147 50.248 13.471 70.603 1.00 41.59 C
ATOM 36 CG ASP 147 51.107 14.730 70.747 1.00 40.94 C
ATOM 37 ODl ASP 147 51.934 14.999 69.861 1.00 39.27 O
ATOM 38 OD2 ASP 147 50.963 15.445 71.765 1.00 40.46 O
ATOM 39 C ASP 147 49.214 11.781 69.097 1.00 41.17 C
ATOM 40 O ASP 147 49.495 10.634 69.483 1.00 41.85 O
ATOM 41 N PHE 148 48.037 12.139 68.582 1.00 39.35 N
ATOM 42 CA PHE 148 46.907 11.228 68.429 1.00 37.65 C
ATOM 43 CB PHE 148 45.772 11.643 69.358 1.00 37.05 C
ATOM 44 CG PHE 148 46.144 11.655 70.801 1.00 36.10 C
ATOM 45 CDl PHE 148 46.524 10.488 71.440 1.00 35.02 C
ATOM 46 CD2 PHE 148 46.087 12.834 71.530 1.00 35.05 C
ATOM 47 CEl PHE 148 46.840 10.496 72.787 1.00 34.98 C
ATOM 48 CE2 PHE 148 46.399 12.849 72.871 1.00 35.65 C
ATOM 49 CZ PHE 148 46.776 11.673 73.501 1.00 34.69 C
ATOM 50 C PHE 148 46.340 11.181 67.015 1.00 36.40 C
ATOM 51 O PHE 148 46.302 12.190 66.314 1.00 36.63 O
ATOM 52 N ASP 149 45. $84 10.000 66.621 1.00 35.96 N
ATOM 53 CA ASP 149 45.368 9.790 65.322 1.00 35.42 C ATOM 54 CB ASP 149 45.913 8.605 64.585 1.00 37.45 C
ATOM 55 CG ASP 149 47.320 8.909 64.089 1.00 39.00 C
ATOM 56 ODl ASP 149 47.538 10.020 63.549 1.00 39.11 O
ATOM 57 OD2 ASP 149 48.199 8.027 64.222 1.00 38.23 O
ATOM 58 C ASP 149 43.790 9.479 65.549 1.00 35.08 C
ATOM 59 O ASP 149 43.454 8.483 66.193 1.00 33.94 O
ATOM 60 N TYR 150 42.912 10.336 65.040 1.00 34.48 N
ATOM 61 CA TYR 150 41.474 10.116 65.164 1.00 34.23 C
ATOM 62 CB TYR 150 40.711 11.321 64.603 1.00 38.35 C
ATOM 63 CG TYR 150 39.206 11.131 64.506 1.00 42.22 C
ATOM 64 CDl TYR 150 38.670 9.937 64.046 1.00 44.00 C
ATOM 65 CEl TYR 150 37.309 9.773 63.899 1.00 46.07 C
ATOM 66 CD2 TYR 150 38.327 12.163 64.822 1.00 42.95 C
ATOM 67 CE2 TYR 150 36.952 12.008 64.670 1.00 45.37 C
ATOM 68 CZ TYR 150 36.454 10.806 64.204 1.00 45.69 C
ATOM 69 OH TYR 150 35.100 10.625 63.999 1.00 46.77 O
ATOM 70 C TYR 150 41.145 8.860 64.362 1.00 32.62 C
ATOM 71 O TYR 150 41.237 8.860 63.134 1.00 32.18 O
ATOM 72 N LEU 151 40.776 7.786 65.057 1.00 30.75 N
ATOM 73 CA LEU 151 40.446 6.519 64.404 1.00 29.67 C
ATOM 74 CB LEU 151 41.063 5.355 65.181 1.00 29.38 C
ATOM 75 CG LEU 151 42.470 4.923 64.753 1.00 30.77 C
ATOM 76 CDl LEU 151 43.292 6.145 64.379 1.00 30.44 C
ATOM 77 CD2 LEU 151 43.134 4.142 65.887 1.00 30.78 C
ATOM 78 C LEU 151 38.952 6.241 64.195 1.00 30.43 C
ATOM 79 O LEU 151 38.563 '5.711 63.147 1.00 30.28 O
ATOM 80 N LYS 152 38.120 6.580 65.181 1.00 28.82 N
ATOM 81 CA LYS 152 36.688 6.334 65.062 1.00 28.23 C
ATOM 82 CB LYS 152 36.450 4.826 65.017 1.00 28.25 C
ATOM 83 CG LYS 152 34.994 4.410 64.949 1.00 29.79 C
ATOM 84 CD LYS 152 34.869 2.989 64.406 1.00 30.80 C
ATOM 85 CE LYS 152 33.442 2.467 64.508 1.00 33.47 C
ATOM 86 NZ LYS 152 32.438 3.276 63.763 1.00 31.99 N
ATOM 87 C LYS 152 35.863 6.961 66.184 1.00 28.16 C
ATOM 88 O LYS 152 36.327 7.081 67.315 1.00 29.23 O
ATOM 89 N LEU 153 34.639 7.371 65.874 1.00 27.82 N
ATOM 90 CA LEU 153 33.776 7.956 66.896 1.00 27.38 C
ATOM 91 CB LEU 153 32.646 8.752 66.265 1.00 28.33 C
ATOM 92 CG LEU 153 31.569 9.187 67.262 1.00 29.42 C
ATOM 93 CDl LEU 153 31.984 10.483 67.945 1.00 28.58 C
ATOM 94 CD2 LEU 153 30.256 9.385 66.526 1.00 31.06 C
ATOM 95 C LEU 153 33.183 6.819 67.710 1.00 27.01 C
ATOM 96 O LEU 153 32.539 5.936 67.159 1.00 25.01 O
ATOM 97 N LEU 154 33.408 6.843 69.018 1.00 28.17 N
ATOM 98 CA LEU 154 32.908 5.793 69.903 1.00 30.32 C
ATOM 99 CB LEU 154 33.926 5.505 71.011 1.00 26.89 C
ATOM 100 CG LEU 154 35.267 4.911 70.566 1.00 27.17 C
ATOM 101 CDl LEU 154 36.256 4.962 71.699 1.00 25.20 C
ATOM 102 CD2 LEU 154 35.077 3.472 70.105 1.00 26.95 C
ATOM 103 C LEU 154 31.549 6.107 70.526 1.00 32.38 C
ATOM 104 O LEU 154 30.825 5.197 70.915 1.00 34.37 O
ATOM 105 N GLY 155 31.194 7.383 70.623 1.00 34.40 N
ATOM 106 CA GLY 155 29.907 7.724 71.206 1.00 36.15 C
ATOM 107 C GLY 155 29.744 9.214 71.370 1.00 36.72 C
ATOM 108 O GLY 155 30.724 9.911 71.610 1.00 36.34 O
ATOM 109 N LYS 156 28.515 9.711 71.255 1.00 38.79 N
ATOM 110 CA LYS 156 28.281 11.150 71.382 1.00 40.81 C
ATOM 111 CB LYS 156 28.294 11.782 69.990 1.00 41.14 C
ATOM 112 CG LYS 156 28.033 13.279 69.959 1.00 44.74 C
ATOM 113 CD LYS 156 29.006 14.055 70.841 1.00 45.97 C
ATOM 114 CE LYS 156 28.737 15.563 70.786 1.00 46.71 C
ATOM 115 NZ LYS 156 27.343 15.912 71.171 1.00 45.33 N
ATOM 116 C LYS 156 27.019 11.590 72.149 1.00 41.59 C
ATOM 117 O LYS 156 25.895 11.214 71.824 1.00 41.44 O
ATOM 118 N GLY 157 27.240 12.407 73.173 1.00 42.58 N
ATOM 119 CA GLY 157 26.155 12.920 73.985 1.00 42.52 C
ATOM 120 C GLY 157 26.186 14.434 73.964 1.00 41.94 C
ATOM 121 O GLY 157 27.032 15.028 73.298 1.00 42.06 O
ATOM 122 N THR 158 25.272 15.058 74.698 1.00 41.52 N
ATOM 123 CA THR 158 25.174 16.514 74.750 1.00 41.08 C
ATOM 124 CB THR 158 23.824 16.919 75.349 1.00 42.00 C
ATOM 125 OGl THR 158 23.746 16.470 76.715 , 1.00 40.83 O
ATOM 126 CG2 THR 158 22.684 16.268 74.544 1.00 42.12 C ATOM 127 C THR 158 26.300 17.141 75.570 1.00 40.81 C
ATOM 128 O THR 158 26.563 18.342 75.494 1.00 40.19 O
ATOM 129 N PHE 159 26.974 16.307 76.344 1.00 40.40 N
ATOM 130 CA PHE 159 28.062 16.753 77.191 1.00 40.68 C
ATOM 131 CB PHE 159 28.058 15.891 78.450 1.00 44.93 C
ATOM 132 CG PHE 159 27.151 14.676 78.349 1.00 48.83 C
ATOM 133 CDl PHE 159 27.225 13.820 77.252 1.00 49.51 C
ATOM 134 CD2 PHE 159 26.227 14.388 79.354 1.00 50.84 C
ATOM 135 CEl PHE 159 26.396 12.701 77.156 1.00 50.19 C
ATOM 136 CE2 PHE 159 25.386 13.262 79.266 1.00 50.98 C
ATOM 137 CZ PHE 159 25.475 12.424 78.166 1.00 51.00 C
ATOM 138 C PHE 159 29.420 16.675 76.481 1.00 38.87 C
ATOM 139 O PHE 159 30.423 17.177 76.991 1.00 38.72 O
ATOM 140 N GLY 160 29.444 16.050 75.301 1.00 37.18 N
ATOM 141 CA GLY 160 30.684 15.906 74.546 1.00 33.86 C
ATOM 142 C GLY 160 30.743 14.647 73.683 1.00 32.71 C
ATOM 143 O GLY 160 29.713 14.069 73.339 1.00 32.46 O
ATOM 144 N LYS 161 31.947 14.211 73.324 1.00 30.90 N
ATOM 145 CA LYS 161 32.090 13.011 72.507 1.00 29.36 C
ATOM 146 CB LYS 161 32.214 13.374 71.024 1.00 30.04 C
ATOM 147 CG LYS 161 33.298 14.383 70.699 1.00 32.54 C
ATOM 148 CD LYS 161 33.511 14.476 69.182 1.00 36.74 C
ATOM 149 CE LYS 161 34.527 15.559 68.799 1.00 38.62 C
ATOM 150 NZ LYS 161 35.017 15.424 67.379 1.00 40.63 N
ATOM 151 C LYS 161 33.267 12.134 72.906 1.00 28.13 C
ATOM 152 O LYS 161 34.251 12.606 73.469 1.00 25.93 O
ATOM 153 N VAL 162 33.144 10.844 72.616 1.00 25.95 N
ATOM 154 CA VAL 162 34.189 9.882 72.925 1.00 25.24 C
ATOM 155 CB VAL 162 33.649 8.711 73.761 1.00 26.92 C
ATOM 15S CGl VAL 162 34.799 8.023 74.489 1.00 25.52 C
ATOM 157 CG2 VAL 162 32.602 9.214 74.734 1.00 27.36 C
ATOM 158 C VAL 162 34.703 9.347 71.595 1.00 25.07 C
ATOM 159 O VAL 162 33.918 9.069 70.691 1.00 22.53 O
ATOM 160 N ILE 163 36.021 9.209 71.486 1.00 26.20 . N
ATOM 161 CA ILE 163 36.653 8.748 70.258 1.00 25.80 C
ATOM 162 CB ILE 163 37.198 9.945 69.453 1.00 27.16 C
ATOM 163 CG2 ILE 163 37.818 9.465 68.145 1.00 27.88 C
ATOM 164 CGl ILE 163 36.075 10.945 69.193 1.00 28.06 C
ATOM 165 CDl ILE 163 36.489 12.139 68.355 1.00 30.30 C
ATOM 166 C ILE 163 37.825 7.805 70.493 1.00 26.45 C
ATOM 167 O ILE 163 38.580 7.973 71.447 1.00 28.01 O
ATOM 168 N LEU 164 37.970 6.813 69.619 1.00 25.85 N
ATOM 169 CA LEU 164 39.090 5.892 69.696 1.00 26.60 C
ATOM 170 CB LEU 164 38.773 4.598 68.943 1.00 25.84 C
ATOM 171 CG LEU 164 39.989 3.713 68.658 1.00 25.73 C
ATOM 172 CDl LEU 164 40.594 3.236 69.968 1.00 23.32 C
ATOM 173 CD2 LEU 164 39.575 2.538 67.782 1.00 23.20 C
ATOM 174 C LEU 164 40.259 6.617 69.015 1.00 27.91 C
ATOM 175 O LEU 164 40.090 7.222 67.957 1.00 29.55 O
ATOM 176 N VAL 165 41.436 6.574 69.619 1.00 30.02 N
ATOM 177 CA VAL 165 42.588 7.247 69.045 1.00 28.95 C
ATOM 178 CB VAL 165 42.740 8.669 69.633 1.00 29.47 C
ATOM 179 CGl VAL 165 41.403 9.405 69.546 1.00 27.28 C
ATOM 180 CG2 VAL 165 43.218 8.606 71.072 1.00 28.69 C
ATOM 181 C VAL 165 43.834 6.436 69.324 1.00 31.51 C
ATOM 182 O VAL 165 43.873 5.654 70.270 1.00 32.51 O
ATOM 183 N ARG 166 44.851 6.610 68.491 1.00 33.58 N
ATOM 184 CA ARG 166 46.095 5.876 68.656 1.00 35.17 C
ATOM 185 CB ARG 166 46.340 4.955 67.468 1.00 35.25 C
ATOM 186 CG ARG 166 47.697 4.278 67.528 1.00 36.24 C
ATOM 187 CD ARG 166 48.492 4.504 66.255 1.00 35.93 C
ATOM 188 NE ARG 166 47.899 3.809 65.124 1.00 36.90 N
ATOM 189 CZ ARG 166 47.381 4.420 64.063 1.00 37.18 C
ATOM 190 NHl ARG 166 47.388 5.746 63.991 1.00 38.40 N
ATOM 191 NH2 ARG 166 46.849 3.706 63.081 1.00 35.42 N
ATOM 192 C ARG 166 47.252 6.842 68.770 1.00 37.13 C
ATOM 193 O ARG 166 47.614 7.500 67.797 1.00 39.66 O
ATOM 194 N GLU 167 47.836 6.928 69.959 1.00 38.21 N
ATOM 195 CA GLU 167 48.952 7.831 70.181 1.00 38.31 C
ATOM 196 CB GLU 167 49.512 7.645 71.593 1.00 39.76 C
ATOM 197 CG GLU 167 50.627 8.615 71.936 1.00 42.63 C
ATOM 198 CD GLU 157 51.246 8.338 73.287 1.00 43.93 C
ATOM 199 OEl GLU 167 ' 52.207 9.050 73.648 1.00 47.14 O ATOM • 200 OK2 GLU 167 50.777 7.416 73.989 1.00 44.30 O
ATOM 201 C GBU 167 50.024 7.524 69.148 1.00 37.87 C
ATOM 202 O GLU 167 50.504 6.391 69.062 1.00 37.80 O
ATOM 203 N LYS 168 50.386 8.536 68.365 1.00 36.84 N
ATOM 204 CA LYS 168 51.388 8.375 67.321 1.00 37.92 C
ATOM 205 CB LYS 168 51.613 9.690 66.570 1.00 37.36 C
ATOM 206 CG LYS 168 50.407 10.313 65.899 1.00 38.60 C
ATOM 207 CD LYS 168 50.889 11.415 64.954 1.00 39.51 C
ATOM 208 CE LYS 168 49.781 12.384 64.555 1.00 40.94 C
ATOM 209 NZ LYS 168 49.415 13.286 65.682 1.00 41.79 N
ATOM 210 C LYS 168 52.736 7.926 67.884 1.00 37.84 C
ATOM 211 O LYS 168 53.318 6.943 67.423 1.00 36.23 O
ATOM 212 N ALA 169 53.218 8.671 68.877 1.00 39.08 N
ATOM 213 CA ALA 169 54.513 8.417 69.508 1.00 40.92 C
ATOM 214 CB ALA 169 54.704 9.368 70.704 1.00 41.39 C
ATOM 215 C ALA 169 54.740 6.979 69.952 1.00 41.43 C
ATOM 216 O ALA 169 55.801 6.417 69.710 1.00 42.34 O
ATOM 217 N SER 170 53.739 6.381 70.590 1.00 41.94 N
ATOM 218 CA SER 170 53.866 5.010 71.083 1.00 41.58 C
ATOM 219 CB SER 170 53.319 4.910 72.510 1.00 41.47 C
ATOM 220 OG SER 170 51.900 4.917 72.502 1.00 40.64 O
ATOM 221 C SER 170 53.141 3.979 70.228 1.00 41.45 C
ATOM 222 O SER 170 53.568 2.828 70.146 1.00 42.38 O
ATOM 223 N GLY 171 52.033 4.380 69.614 1.00 40.63 N
ATOM 224 CA GLY 171 51.276 3.438 68.813 1.00 40.69 C
ATOM 225 C GLY 171 50.290 2.656 69.669 1.00 39.74 C
ATOM 226 O GLY 171 49.741 1.644 69.235 1.00 39.88 O
ATOM 227 K LYS 172 50.059 3.128 70.890 1.00 39.45 N
ATOM 228 CA LYS 172 49.128 2.468 71.796 1.00 37.45 C
ATOM 229 CB LYS 172 49.613 2.597 73.238 1.00 39.63 C
ATOM 230 CG LYS 172 51.059 2.158 73.429 1.00 41.34 C
ATOM 231 CD LYS 172 51.391 1.935 74.894 1.00 42.32 C
ATOM 232 CE LYS 172 50.806 0.619 75.395 1.00 43.45 C
ATOM 233 NZ LYS 172 51.485 -0.554 74.782 1.00 43.42 N
ATOM 234 C LYS 172 47.755 3.105 71.646 1.00 36.72 C
ATOM 235 O LYS 172 47.638 4.303 71.353 1.00 33.90 O
ATOM 236 N TYR 173 46.716 2.297 71.852 1.00 35.79 N
ATOM 237 CA TYR 173 45.350 2.765 71.705 1.00 34.10 C
ATOM 238 CB TYR 173 44.480 1.665 71.103 1.00 34.55 C
ATOM 239 CG TYR 173 44.964 1.202 69.747 1.00 34.64 C
ATOM 240 CDl TYR 173 45.780 0.081 69.618 1.00 32.00 C
ATOM 241 CEl TYR 173 46.250 -0.313 68.377 1.00 33.44 C
ATOM 242 CD2 TYR 173 44.633 1.912 68.596 1.00 33.03 C
ATOM 243 CE2 TYR 173 45.098 1.528 67.357 1.00 32.11 C
ATOM 244 CZ TYR 173 45.903 0.418 67.249 1.00 32.04 C
ATOM 245 OH TYR 173 46.342 0.027 66.004 1.00 33.95 O
ATOM 246 C TYR 173 44.726 3.244 72.991 1.00 34.33 C
ATOM 247 O TYR 173 45.015 2.717 74.062 1.00 34.95 O
ATOM 248 N TYR 174 43.854 4.242 72.867 1.00 33.96 N
ATOM 249 CA TYR 174 43.163 4.820 74.015 1.00 33.54 C
ATOM 250 CB TYR 174 43.967 5.992 74.603 1.00 34.42 C
ATOM 251 CG TYR 174 45.346 5.626 75.091 1.00 35.78 C
ATOM 252 CDl TYR 174 45.523 4.704 76.113 1.00 36.07 C
ATOM 253 CEl TYR 174 46.798 4.363 76.557 1.00 36.11 C
ATOM 254 CD2 TYR 174 46.475 6.199 74.525 1.00 34.71 C
ATOM 255 CE2 TYR 174 47.741 5.863 74.959 1.00 35.48 C
ATOM 256 CZ TYR 174 47.900 4.948 75.971 1.00 35.50 C
ATOM 257 OH TYR 174 49.171 4.612 76.387 1.00 37.06 O
ATOM 258 C TYR 174 41.796 5.344 73.613 1.00 32.68 C
ATOM 259 O TYR 174 41.429 5.352 72.435 1.00 32.64 O
ATOM 260 N ALA 175 41.048 5.792 74.612 1.00 32.21 N
ATOM 261 CA ALA 175 39.732 6.367 74.393 1.00 31.66 C
ATOM 262 CB ALA 175 38.660 5.550 75.123 1.00 32.73 C
ATOM 263 C ALA 175 39.773 7.793 74.934 1.00 29.89 C
ATOM 264 O ALA 175 40.037 8.005 76.112 1.00 28.94 O
ATOM 265 N MET 176 39.528 8.772 74.068 1.00 30.50 N
ATOM 266 CA MET 176 39.533 10.169 74.492 1.00 30.41 C
ATOM 267 CB MET 176 40.348 11.030 73.528 1.00 29.22 C
ATOM 268 CG MET 176 40.438 12.484 73.964 1.00 28.98 C
ATOM 269 SD MET 176 41.163 13.572 72.706 1.00 29.50 S
ATOM 270 CE MET 176 42.821 12.891 72.577 1.00 27.37 C
ATOM 271 C MET 176 38.132 10.757 74.605 1.00 30.64 C
ATOM 272 O MET 176 37.375 10.773 73.631 1.00 28.75 O ATOM 273 N LYS 177 37.796 11.226 75.806 00 31.04 N
ATOM 274 CA LYS 177 36.505 11.852 76.051 00 32.98 C
ATOM 275 CB LYS 111 35.979 11.542 77.461 00 32.65 C
ATOM 276 CG LYS 111 35.487 10.120 77.662 00 32.24 C
ATOM 277 CD LYS 111 34.524 10.030 78.841 00 33.41 C
ATOM 278 CE LYS 177 34.160 8.571 79.156 00 34.13 C
ATOM 279 NZ LYS 111 33.033 8.423 80.147 00 33.04 N
ATOM 280 C LYS 111 36.660 13.356 75.902 00 32.87 C
ATOM 281 O LYS 111 37.408 13.993 76.637 00 33.08 O
ATOM 282 N ILE 178 35.957 13.918 74.932 00 34.36 N
ATOM 283 CA ILE 178 36.007 15.346 74.697 00 35.23 C
ATOM 284 CB ILE 178 36.085 15.651 73.188 00 37.00 C
ATOM 285 CG2 ILE 178 36.069 17.163 72.949 00 34.57 C
ATOM 286 CGl ILE 178 37.388 15.092 72.622 00 38.10 C
ATOM 287 CDl ILE 178 37.663 13.670 73.022 00 41.54 C
ATOM 288 C ILE 178 34.741 15.950 75.298 00 36.38 C
ATOM 289 O ILE 178 33.629 15.671 74.840 00 35.42 O
ATOM 290 N LEU 179 34.931 16.768 76.334 00 37.19 N
ATOM 291 CA LEU 179 33.839 17.417 77.051 00 37.70 C
ATOM 292 CB LEU 179 34.050 17.234 78.553 00 37.65 C
ATOM 293 CG LEU 179 34.249 15.784 78.996 00 39.23 C
ATOM 294 CDl LEU 179 35.022 15.749 80.291 1.00 39.12 C
ATOM 295 CD2 LEU 179 32.896 15.096 79.148 39.61 C
ATOM 296 C LEU 179 33.752 18.905 76.736 38.00 C
ATOM 297 O LEU 179 34.767 19.600 76.711 37.50 O
ATOM 298 N LYS 180 32.537 19.396 76.512 39.20 N
ATOM 299 CA LYS 180 32.327 20.813 76.205 41.11 C
ATOM 300 CB LYS 180 30.943 21.023 75.606 42.35 C
ATOM 301 CG LYS 180 30.506 19.974 74.622 42.93 C
ATOM 302 CD LYS 180 29.059 20.210 74.235 42.93 C
ATOM 303 CE LYS 180 28.668 19.294 73.102 43.61 C
ATOM 304 NZ LYS 180 29.620 19.471 71.981 43.55 N
ATOM 305 C LYS 180 32.4OO 21.634 77.483 41.57 C
ATOM 306 O LYS 180 31.455 21.613 78.268 40.33 O
ATOM 307 N LYS 181 33.494 22.363 77.702 42.79 N
ATOM 308 CA LYS 181 33.610 23.167 78.930 44.34 C
ATOM 309 CB LYS 181 34.739 24.205 78.807 44.72 C
ATOM 310 CG LYS 181 36.142 23.648 79.077 46.11 C
ATOM 311 CD LYS 181 37.255 24.615 78.627 46.21 C
ATOM 312 CE LYS 181 38.631 24.058 78.981 47.03 C
ATOM 313 NZ LYS 181 39.732 24.691 78.194 47.29 N
ATOM 314 C LYS 181 32.308 23.882 79.275 44.93 C
ATOM 315 O LYS 181 31.729 23.667 80.342 1.00 43.79 O
ATOM 316 N GLU 182 31.844 24.727 78.358 46.99 N
ATOM 317 CA GLU 182 30.620 25.484 78.583 48.77 C
ATOM 318 CB GLU 182 30.319 26.392 77.384 51.03 C
ATOM 319 CG GLU 182 30.882 25.927 76.042 55.17 C
ATOM 320 CD GLU 182 30.062 24.825 75.404 56.88 C
ATOM 321 OEl GLU 182 30.340 24.480 74.235 57.57 O
ATOM 322 OE2 GLU 182 29.140 24.303 76.073 58.99 O
ATOM 323 C GLU 182 29.389 24.654 78.936 48.27 C
ATOM 324 O GLU 182 28.473 25.160 79.594 49.14 O
ATOM 325 N VAL 183 29.346 23.389 78.523 47.25 N
ATOM 326 CA VAL 183 28.189 22.565 78.862 44.75 C
ATOM 327 CB VAL 183 28.011 21.374 77.884 44.52 C
ATOM 328 CGl VAL 183 29.234 20.479 77.907 46.08 C
ATOM 329 CG2 VAL 183 26.771 20.577 78.267 43.47 C
ATOM 330 C VAL 183 28.344 22.061 80.296 43.32 C
ATOM 331 O VAL 183 27.386 22.046 81.063 43.11 O
ATOM 332 N ILE 184 29.557 21.664 80.663 42.44 N
ATOM 333 CA ILE 184 29.824 21.200 82.023 42.45 C
ATOM 334 CB ILE 184 31.309 20.882 82.232 40.71 C
ATOM 335 CG2 ILE 184 31.630 20.895 83.711 40.11 C
ATOM 336 CGl ILE 184 31.653 19.546 81.584 37.82 C
ATOM 337 CDl ILE 184 33.124 19.247 81.585 37.75 C
ATOM 338 C ILE 184 29.484 22.353 82.942 43.92 C
ATOM 339 O ILE 184 28.701 22.218 83.894 45.33 O
ATOM 340 N ILE 185 30.086 23.498 82.652 44.32 N
ATOM 341 CA ILE 185 29 839 24.691 83.447 44.74 C
ATOM 342 CB ILE 185 30 488 25.939 82.807 44.36 C
ATOM 343 CG2 ILE 185 29 871 27.193 83.386 44.28 C
ATOM 344 CGl ILE 185 31.998 25.930 83.043 43.46 C
ATOM 345 CDl ILE 185 32.722 27.072 82.354 1.00 42.05 C 69
ATOM 346 C ILE 185 28.341 24.934 83.565 1.00 44.81 C ATOM 347 0 ILE 185 27.802 24.996 84.660 1.00 44.67 O ATOM 348 N ALA 186 27.671 25.056 82.424 1.00 46.56 N ATOM 349 CA ALA 186 26.234 25.318 82.401 1.00 47.03 C ATOM 350 CB ALA 186 25.746 25.449 80.964 1.00 46.91 C ATOM 351 C ALA 186 25.396 24.285 83.137 00 47.13 C ATOM 352 O ALA 186 24.175 24.363 83.122 00 47.33 O ATOM 353 N LYS 187 26.039 23.321 83.783 00 48.49 N ATOM 354 CA LYS 187 25.300 22.306 84.528 00 50.76 C ATOM 3 35555 C CBB LYS 187 25.274 20.997 83.746 1.00 52.83 C ATOM 335566 CG LYS 187 26.550 20.179 83.873 1.00 54.88 C ATOM 335577 CD LYS 187 26.646 19.532 85.247 1.00 56.43 C ATOM 358 CE LYS 187 25.443 18.621 85.497 57.79 C ATOM 359 NZ LYS 187 24.135 19.344 85:389 58.60 N ATOM 3 36600 C C L LYYSS 187 25.941 22.056 85.890 51.57 C ATOM 3 3 3666111 O O L LYYSS 187 25.393 21.324 86.718 51.42 O ATOM 3 33666222 N N A ASSPP 188 27.108 22.662 86.110 52.14 N ATOM 336633 CA ASP 188 27.861 22.502 87.359 52.33 C ATOM 336644 CB ASP 188 26.969 21.983 88.478 52.44 C ATOM 336655 CG ASP 188 25.759 22.838 88.683 53.58 C ATOM 366 ODl ASP 188 25.908 24.075 88.796 53.83 O ATOM 367 ' OD2 ASP 188 24.651 22.269 88.737 55.29 O ATOM 3 36688 C ASP 188 28.972 21.493 87.130 51.69 C ATOM 336699 O A ASSPP 188 29.861 21.708 86.295 52.48 O ATOM 370 N G GLLUU 189 28.918 20.402 87.889 50.12 N ATOM 371 CA GLU 189 29.895 19.326 87.779 48.66 C ATOM 372 CB GLU 189 29.624 18.504 86.507 49.63 C ATOM 373 CG GLU 189 29.188 17.043 86.754 51.19 C ATOM 374 CD GLU 189 27.897 16.930 87.559 1.00 50.98 C ATOM 375 OEl GLU 189 26.935 17.653 87.214 00 51.39 O ATOM 376 OE2 GLU 189 27.838 16.116 88.518 00 49.58 O ATOM 377 C GLU 189 31.346 19.802 87.763 00 46.30 C ATOM 378 0 G GLLUU 189 32.249 19.040 88.110 00 46.18 O ATOM 379 N V VAALL 190 31.564 21.052 87.362 1.00 4 433..4422 N ATOM 380 CA VAL 190 32.909 21.606 87.272 1.00 4 411..8822 C ATOM 381 CB VAL 190 ■32.890 23.149 87.290 1.00 40.89 C ATOM 382 CGl VAL 190 34.151 23.665 87.950 1.00 40.57 C ATOM 3 38833 CG2 VAL 190 32.801 23.680 85.869 1.00 38.69 C ATOM 338844 C VAL 190 33.835 21.107 88.374 1.00 40.61 C ATOM 338855 O VAL 190 34.900 20.560 88.094 1.00 39.29 O ATOM 338866 N ALA 191 33.426 21.300 89.623 1.00 39.95 N ATOM 387 CA ALA 191 34.221 20.852 90.763 1.00 39.91 C ATOM 388 CB ALA 191 33.590 21.344 92.060 1.00 39.95 C ATOM 389 C ALA 191 34.258 19.326 90.747 1.00 39.92 C ATOM 390 O A ALLAA 191 35.303 18.697 90.933 1.00 39.25 O ATOM 391 N HHIISS 192 33.096 18.737 90.515 1.00 40.28 N ATOM 392 CA HIS 192 32.982 17.294 90.477 00 41.44 C ATOM 393 CB HIS 192 31.590 16.910 90.025 00 42.35 C ATOM 394 CG HIS 192 31.310 15.454 90.157 00 43.21 C ATOM 395 CD2 HIS 192 31.938 14.492 90.873 1.00 43.63 C ATOM 396 NDl HIS 192 30.231 14.847 89.553 1.00 43.93 N ATOM 397 CEl HIS 192 30.204 13.571 89.895 1.00 44.79 C ATOM 398 NE2 HIS 192 31.230 13.331 90.696 ,00 45 ..04 N ATOM 399 C HIS 192 33.980 16.687 89.505 ,00 40.85 C ATOM 400 O HIS 192 34.658 15.700 89.800 ,00 40.61 O ATOM 401 N THR 193 34.051 17.301 88.335 ,00 40.21 N ATOM 402 CA THR 193 34.905 16.846 87.266 ,00 40.51 C ATOM 403 CB THR 193 34.564 17.608 85.989 ,00 40.64 C ATOM 404 OGl THR 193 33.166 17.445 85.721 ,00 41.61 O ATOM 405 CG2 THR 193 35.360 17.081 84.817 ,00 40.46 C ATOM 4 40066 C C T THHRR 193 36.392 16.953 87.551 ,00 40.68 C ATOM 407 O T THHRR 193 37.124 15.976 87.415 .00 40.17 O ATOM 408 N LLEEUU 194 36.850 18.135 87.936 ,00 41.55 N ATOM 409 CA LEU 194 38.268 18.309 88.222 ,00 42.05 C ATOM 410 CB LEU 194 38.562 19.781 88.512 ,00 42.37 C ATOM 411 CG LEU 194 38.099 20.706 87.369 1.00 43.80 C ATOM 412 CDl LEU 194 38.338 22.165 87.764 1.00 43.11 C ATOM 413 CD2 LEU 194 38.846 20.359 86.054 1.00 41.87 C ATOM 414 C LEU 194 38.670 17.428 89.401 1.00 42.72 C ATOM 415 0 L LEEUU 194 39.791 16.917 89.461 1.00 41.75 O ATOM 416 N TTHHRR 195 37.741 17.241 90.334 1.00 43.83 N ATOM 417 CA THR 195 38.015 16.415 91.498 1.00 45.39 C ATOM 418 CB THR 195 36.858 16.484 92.530 1.00 46.78 C US2004/026569
ATOM 419 OGl THR 195 35.599 16.244 91.880 00 49.79 O
ATOM 420 CG2 THR 195 36.823 17.857 93.185 00 47.54 C
ATOM 421 C THR 195 38.246 14.975 91.063 00 44.94 C
ATOM 422 O THR 195 39.368 14.470 91.142 .00 44.58 O
ATOM 423 N GLU 196 37.209 14.310 90.571 ,00 44.52 N
ATOM 424 CA GLU 196 37.406 12.927 90.158 ,00 45.15 C
ATOM 425 CB GLU 196 36.164 12.381 89.460 ,00 45.88 C
ATOM 426 CG GLU 196 35.516 13.326 88.479 ,00 48.31 C
ATOM 427 CD GLU 196 34.387 12.654 87.723 ,00 49.61 C
ATOM 428 OEl GLU 196 33.657 13.352 86.976 ,00 51.19 O
ATOM 429 OE2 GLU 196 34.237 11.417 87.875 .00 49.65 O
ATOM 430 C GLU 196 38.628 12.774 89.260 ,00 44.79 C
ATOM 431 O GLU 196 39.400 11.831 89.411 ,00 44.89 O
ATOM 432 N SER 197 38.819 13.701 88.332 ,00 44.31 N
ATOM 433 CA SER 197 39.968 13.619 87.442 .00 44.56 C
ATOM 434 CB SER 197 39.971 14.789 86.478 .00 44.80 C
ATOM 435 OG SER 197 40.157 15.990 87.202 ,00 46.44 O
ATOM 436 C SER 197 41.292 13.613 88.212 ,00 44.60 C
ATOM 437 O SER 197 42.251 12.980 87.781 .00 44.03 O
ATOM 438 N . ARG 198 41.354 14.331 89.333 .00 45.21 N
ATOM 439 CA ARG 198 42.574 14.365 90.139 ,00 46.16 C
ATOM 440 CB ARG 198 42.589 15.586 91.062 ,00 46.59 C
ATOM 441 CG ARG 198 42.911 16.898 90.356 .00 48.66 C
ATOM 442 CD ARG 198 42.304 18.091 91.093 .00 50.17 C
ATOM 443 NE ARG 198 43.073 18.543 92.255 .00 51.24 N
ATOM 444 CZ ARG 198 42.525 19.153 93.305 .00 5(2.69 C
ATOM 445 NHl ARG 198 41.208 19.365 93.331 .00 52.73 N
ATOM 446 NH2 ARG 198 43.281 19.572 94.318 .00 51.56 N
ATOM 447 C ARG 198 42.652 13.094 90.971 .00 46.61 C
ATOM 448 O ARG 198 43.533 12.947 91.812 .00 47.19 O
ATOM 449 N VAL 199 41.711 12.183 90.734 .00 47.02 N
ATOM 450 CA VAL 199 41.656 10.899 91.426 .00 46.38 C
ATOM 451 CB VAL 199 40.267 10.630 92.052 .00 45.05 C
ATOM 452 CGl VAL 199 40.158 9.155 92.423 .00 44.51 C
ATOM 453 CG2 VAL 199 40.060 11.492 93.282 .00 44.31 C
ATOM 454 C VAL 199 41.901 9.797 90.411 .00 46.84 C
ATOM 455 O VAL 199 42.293 8.687 90.758 .00 47.88 O
ATOM 456 N LEU 200 41.661 10.120 89.150 .00 48.16 N
ATOM 457 CA LEU 200 41.812 9.164 88.064 .00 50.03 C
ATOM 458 CB LEU 200 41.212 9.735 86.776 .00 49.97 C
ATOM 459 CG LEU 200 40.228 8.7S9 86.134 .00 50.46 C
ATOM 460 CDl LEU 200 40.922 7.416 85.886 .00 50.06 C
ATOM 461 CD2 LEU 200 39.034 8.567 87.068 .00 50.58 C
ATOM 462 C LEU 200 43.235 8.708 87.782 .00 50.42 C
ATOM 463 O LEU 200 43.458 7.548 87.404 .00 51.77 O
ATOM 464 N LYS 201 44.195 9.609 87.943 .00 49.81 N
ATOM 465 CA LYS 201 45.582 9.255 87.684 .00 50.86 C
ATOM 466 CB LYS 201 46.323 10.419 87.012 .00 52.08 C
ATOM 467 CG LYS 201 46.388 11.711 87.825 .00 51.71 C
ATOM 468 CD LYS 201 45.027 12.390 87.946 .00 52.33 C
ATOM 469 CE LYS 201 44.177 11.763 89.052 .00 51.21 C
ATOM 470 NZ LYS 201 44.882 11.766 90.352 .00 49.75 N
ATOM 471 C LYS 201 46.310 8.840 .88.948 .00 50.81 C
ATOM 472 O LYS 201 47.262 8.062 88.886 .00 51.96 O
ATOM 473 N ASN 202 45.867 9.353 90.094 .00 50.07 N
ATOM 474 CA ASN 202 46.491 9.006 91.364 .00 49.05 C
ATOM 475 CB ASN 202 46.248 10.096 92.417 .00 51.48 C
ATOM 476 CG ASN 202 46.998 11.378 92.108 .00 54.87 C
ATOM 477 ODl ASN 202 47.037 12.315 92.923 .00 55.74 O
ATOM 478 ND2 ASN 202 47.601 11.434 90.916 .00 56.59 N
ATOM 479 C ASN 202 45.953 7.688 91.883 .00 46.84 C
ATOM 480 O ASN 202 46.026 7.412 93.079 .00 47.06 O
ATOM 481 N THR 203 45.426 6.866 90.983 .00 43.70 N
ATOM 482 CA THR 203 44.860 5.589 91.383 .00 40.55 C
ATOM 483 CB THR 203 43.341 5.704 91.556 .00 39.57 C
ATOM 484 OGl THR 203 42.749 6.072 90.306 .00 37.14 O
ATOM 485 CG2 THR 203 43.010 6.768 92.592 .00 40.93 C
ATOM 486 C THR 203 45.142 4.545 90.325 .00 39.17 C
ATOM 487 O THR 203 45.296 878 89.159 .00 38.34 O
ATOM 488 N ARG 204 45.206 283 90.736 .00 37.30 N
ATOM 489 CA ARG 204 45.456 200 89.803 1.00 36. 89 C
ATOM 490 CB ARG 204 46.959 018 89.638 1.00 41.11 C
ATOM 491 CG ARG 204 47.382 230 88.420 1.00 46.25 C ATOM 492 CD ARG 204 48.847 1.560 88.134 1.00 52.48 C
ATOM 493 NE ARG 204 49.037 2.995 87.862 1.00 56.48 N
ATOM 494 CZ ARG 204 50.136 3.682 88.181 1.00 58.37 C
ATOM 495 NHl ARG 204 51.151 3.070 88.793 1.00 59.09 N
ATOM 496 NH2 ARG 204 50.226 4.980 87.884 1.00 58.63 N
ATOM 497 C ARG 204 44.806 0.903 90.294 1.00 34.31 C
ATOM 498 O ARG 204 45.139 0.383 91.358 1.00 33.46 O
ATOM 499 N HIS 205 43.878 0.381 89.502 1.00 31,93 N
ATOM 500 CA HIS 205 43.171 -0.841 89.865 1.00 28.33 C
ATOM 501 CB HIS 205 42.021 -0.499 90.812 1.00 25.87 C
ATOM 502 CG HIS 205 41.345 -1.695 91.402 1.00 26.19 C
ATOM 503 CD2 HIS 205 40.253 -2.387 91.003 1.00 23.99 C
ATOM 504 NDl HIS 205 41.796 -2.316 92.546 1.00 25.63 N
ATOM 505 CEl HIS 205 41.008 -3.336 92.831 1.00 23.45 C
ATOM 506 NE2 HIS 205 40.065 -3.402 91.910 1.00 25.80 N
ATOM 507 C HIS 205 42.631 -1.535 88.618 1.00 26.81 C
ATOM 508 O HIS 205 42.199 -0.887 87.671 1.00 26.83 O
ATOM 509 N PRO 206 42.643 -2.878 88.612 1.00 26.63 N
ATOM 510 CD PRO 206 43.125 -3.693 89.739 1.00 25.02 C
ATOM 511 CA PRO 206 42.171 -3.731 87.510 1.00 25.91 C
ATOM 512 CB PRO 206 42.254 -5.136 88.098 1.00 26.31 C
ATOM 513 CG PRO 206 43.371 -5.020 89.084 1.00 27.14 C
ATOM 514 C PRO 206 40.754 -3.418 87.059 1.00 25.98 C
ATOM 515 O PRO 206 40.403 -3.582 85.891 1.00 26.29 O
ATOM 516 N PHE 207 39.938 -2.963 87.995 1.00 25.80 N
ATOM 517 CA PHE 207 38.552 -2.680 87.688 1.00 26.67 C
ATOM 518 CB PHE 207 37.688 -3.434 88.698 1.00 25.40 C
ATOM 519 CG PHE 207 38.044 -4.898 88.794 1.00 24.29 C
ATOM 520 CDl PHE 207 38.004 -5.704 87.673 1.00 25.37 C
ATOM 521 CD2 PHE 207 38.461 -5.454 89.981 1.00 24.92 C
ATOM 522 CEl PHE 207 38.372 -7.033 87.731 1.00 24.50 C
ATOM 523 CE2 PHE 207 38.834 -6.791 90.046 1.00 24.80 C
ATOM 524 CZ PHE 207 38.787 -7.577 88.916 1.00 23.90 C
ATOM 525 C PHE 207 38.201 -1.195 87.594 1.00 27.32 C
ATOM 526 O PHE 207 37.033 -0.819 87.607 1.00 27.22 O
ATOM 527 N LEU 208 39.229 -0.361 87.476 1.00 27.94 N
ATOM 528 CA LEU 208 39.049 1.078 87.320 1.00 29.33 C
ATOM 529 CB LEU 208 39.861 1.857 88.353 1.00 29.89 C
ATOM 530 CG LEU 208 39.383 1.840 89.797 1.00 33.61 C
ATOM 531 CDl LEU 208 40.182 2.871 90.585 1.00 33.64 C
ATOM 532 CD2 LEU 208 37.892 2.169 89.855 1.00 33.75 C
ATOM 533 C LEU 208 39.584 1.413 85.941 1.00 29.83 C
ATOM 534 O LEU 208 40.621 0.887 85.548 1.00 29.85 O
ATOM 535 N THR 209 38.892 2.274 85.203 1.00 30.28 N
ATOM 536 CA THR 209 39.371 2.653 83.876 1.00 30.90 C
ATOM 537 CB THR 209 38.253 3.212 83.001 1.00 31.46 C
ATOM 538 OGl THR 209 37.143 2.307 82.386 1.00 34.68 O
ATOM 539 CG2 THR 209 38.759 3.400 81.594 1.00 33.54 C
ATOM 540 C THR 209 40.405 3.756 84.057 1.00 30.88 C
ATOM 541 O THR 209 40.044 4.920 84.229 1.00 32.29 O
ATOM 542 N SER 210 41.685 3.400 83.997 1.00 29.64 N
ATOM 543 CA SER 210 42.754 4.373 84.208 1.00 29.12 C
ATOM 544 CB SER 210 44.111 3.661 84.214 1.00 28.50 C
ATOM 545 OG SER 210 44.269 2.826 83.086 1.00 29.18 O
ATOM 546 C SER 210 42.812 5.587 83.288 1.00 29.27 C
ATOM 547 O SER 210 42.489 5.519 82.102 1.00 29.02 O
ATOM 548 N LEU 211 43.224 6.711 83.867 1.00 30.36 N
ATOM 549 CA LEU 211 43.355 7.980 83.145 1.00 32.59 C
ATOM 550 CB LEU 211 42.952 9.151 84.047 1.00 32.32 C
ATOM 551 CG LEU 211 42.436 10.421 83.363 1.00 33.42 C
ATOM 552 CDl LEU 211 42.562 11.597 84.321 1.00 32.22 C
ATOM 553 CD2 LEU 211 43.222 10.685 82.089 1.00 32.56 C
ATOM 554 C LEU 211 44.818 8.139 82.729 1.00 32.95 C
ATOM 555 O LEU 211 45.701 8.195 83.580 1.00 33.18 O
ATOM 556 N LYS 212 45.065 8.215 81.423 1.00 34.64 N
ATOM 557 CA LYS 212 46.424 8.334 80.892 1.00 35.67 C
ATOM 558 CB LYS 212 46.498 7.672 79.520 1.00 36.44 C
ATOM 559 CG LYS 212 47.720 8.067 78.716 1.00 38.53 C
ATOM 560 CD LYS 212 49.018 7.656 79.386 1.00 41.09 C
ATOM 561 CE LYS 212 49.444 6.238 78.987 1.00 43.42 C
ATOM 562 NZ LYS 212 50.805 5.894 79.516 1.00 43.58 N
ATOM 563 C LYS 212 46.966 9.760 80.798 1.00 36.17 C
ATOM 564 O LYS 212 48.070 10.046 81.274 1.00 36.98 O ATOM 565 N TYR 213 46.209 10 J646 80.164 1.00 35.63 N
ATOM 566 CA TYR 213 46.631 12.040 80.033 1.00 36.94 C
ATOM 567 CB TYR 213 47.327 12.'303 78.694 1.00 36.86 C
ATOM 5G8 CG TYR 213 48.419 11.344 78.287 1.00 36.76 C
ATOM 569 CDl TYR 213 49.620 11 J 277 78.981 1.00 36.66 C
ATOM 570 CEl TYR 213 50.656 10.473 78.535 1.00 36.41 C
ATOM 571 CD2 TYR 213 48.284 10.570 77.143 1.00 36.46 C
ATOM 572 CE2 TYR 213 49.312 9.764 76.695 1.00 36.66 C
ATOM 573 CZ TYR 213 50.498 9- 721 77.391 1.00 36.23 C
ATOM 574 OH TYR 213 51.528 8.933 76.916 1.00 36.40 O
ATOM 575 C TYR 213 45.396 12.919 80.083 1.00 36.11 C
ATOM 576 O TYR 213 44.275 12 -429 79.982 1.00 36.45 O
ATOM 577 N SER 214 45.613 14.221 80.223 1.00 37.27 N
ATOM 578 CA SER 214 44.517 15.193 80.267 1.00 37.68 C
ATOM 579 CB SER 214 43.944 15.296 81.675 1.00 36.31 C
ATOM 580 OG SER 214 43.464 14.045 82.103 1.00 40.46 O
ATOM 581 C SER 214 45.024 16.563 79.842 1.00 37.83 C
ATOM 582 O SER 214 46.153 16.933 80.167 1.00 38.34 O
ATOM 583 N PHE 215 44.194 17.293 79.099 1.00 38.73 N
ATOM 584 CA PHE 215 44.518 18.640 78.639 1.00 39.23 C
ATOM 585 CB PHE 215 45.551 18.623 77.493 1.00 36.92 C
ATOM 586 CG PHE 215 45.109 17.867 76.269 1.00 37.87 C
ATOM 587 CDl PHE 215 45.188 16.483 76.218 1.00 37.20 C
ATOM 588 CD2 PHE 215 44.610 18.543 75.163 1.00 37.24 C
ATOM 589 CEl PHE 215 44.777 15.794 75.093 1.00 36.55 C
ATOM 590 CE2 PHE 215 44.197 17.851 74.033 1.00 37.11 C
ATOM 591 CZ PHE 215 44.280 16.481 73.998 1.00 37.33 C
ATOM 592 C PHE 215 43.245 19.380 78.214 1.00 41.14 C
ATOM 593 O PHE 215 42.155 18.778 78.108 1.00 40.14 O
ATOM 594 N GLN 216 43.378 20.691 77.998 1.00 42.54 N
ATOM 595 CA GLN 216 42.241 21.524 77.607 1.00 44.64 C
ATOM 596 CB GLN 216 41.986 22.605 78.672 1.00 46.88 C
ATOM 597 CG GLN 216 43.189 22.960 79.560 1.00 49.00 C
ATOM 598 CD GLN 216 43.283 22.095 80.828 1.00 50.97 C
ATOM 599 OEl GLN 216 43.447 20.878 80.759 1.00 50.70 O
ATOM 600 NE2 GLN 216 43.175 22.736 81.994 1.00 51.24 N
ATOM 601 C GLN 216 42.392 22.178 76.237 1.00 44.81 C
ATOM 602 O GLN 216 43.431 22.042 75.586 1.00 45.98 O
ATOM 603 N THR 217 41.348 22.884 75.800 1.00 45.83 N
ATOM 604 CA THR 217 41.351 23.563 74.506 1.00 47.00 C
ATOM 605 CB THR 217 40.632 22.747 73.423 1.00 46.17 C
ATOM 606 OGl THR 217 39.231 22.660 73.743 1.00 46.81 O
ATOM 607 CG2 THR 217 41.219 21.361 73.332 1.00 45.91 C
ATOM 608 C THR 217 40.595 24.871 74.626 1.00 48.19 C
ATOM 609 O THR 217 40.475 25.439 75.715 1.00 47.91 O
ATOM 610 N LYS 218 40.076 25.344 73.497 1.00 49.50 N
ATOM 611 CA LYS 218 39.304 26.574 73.505 1.00 50.02 C
ATOM 612 CB LYS 218 38.737 2S .888 72.100 1.00 50.77 C
ATOM 613 CG LYS 218 38.128 25.698 71.349 1.00 50.42 C
ATOM 614 CD LYS 218 37.002 2S.137 70.404 1.00 50.08 C
ATOM 615 CE LYS 218 37.486 27.055 69.289 1.00 49.13 C
ATOM 616 NZ LYS 218 38.304 26.321 68.268 1.00 49.73 N
ATOM 617 C LYS 218 38.181 26.354 74.511 1.00 49.95 C
ATOM 618 O LYS 218 38.228 26.873 75.621 1.00 50.86 O
ATOM 619 N ASP 219 37.191 25.552 74.145 1.00 49.42 N
ATOM 620 CA ASP 219 36.064 25.294 75.048 1.00 49.26 C
ATOM 621 CB ASP 219 34.787 25.845 74.414 1.00 51.11 C
ATOM 622 CG ASP 219 34.360 25.047 73.191 1.00 52.54 C
ATOM 623 ODl ASP 219 34.030 23.852 73.365 1.00 53.56 O
ATOM 624 OD2 ASP 219 34.361 25.598 72.063 1.00 53.57 O
ATOM 625 C ASP 219 35.868 23.793 75.345 1.00 48.05 C
ATOM 626 O ASP 219 34.795 23.380 75.808 1.00 47.50 O
ATOM 627 N ARG 220 36.902 22.989 75.102 1.00 46.58 N
ATOM 628 CA ARG 220 36.808 21.545 75.296 1.00 44.92 C
ATOM 629 CB ARG 220 37.090 20.841 73.960 1.00 46.99 C
ATOM 630 CG ARG 220 36.300 21.381 72.764 1.00 49.79 C
ATOM 631 CD ARG 220 34.85S 2O.884 72.767 1.00 52.44 C
ATOM 632 NE ARG 220 33.993 21.667 71.877 1.00 55.26 N
ATOM 633 CZ ARG 220 32.675 21.491 71.768 1.00 56.57 C
ATOM 634 NHl ARG 220 32.062 20.551 72.492 1.00 56.51 N
ATOM 635 NH2 ARG 220 31.964 22.262 70.949 1.00 56.80 N
ATOM 636 C ARG 220 37.742 20.973 76.364 1.00 43.48 C
ATOM 637 O ARG 220 38.893 21.398 76.510 1.00 42.24 O 69
ATOM S38 N LEU 221 37.240 19.991 77.107 1.00 41.85 N
ATOM 639 CA LEU 221 38.038 19.338 78.139 1.00 39.64 C
ATOM 640 CB LEU 221 37.308 19.353 79.477 1.00 41.88 C
ATOM 641 CG LEU 221 38.211 18.887 80.621 1.00 43.36 C
ATOM 642 CDl LEU 221 39.458 19.771 80.638 1.00 44.74 C
ATOM 643 CD2 LEU 221 37.477 18.965 81.956 1.00 43.38 C
ATOM 644 C LEU 221 38.287 17.900 77.706 1.00 37.35 C
ATOM 645 O LEU 221 37.351 17.119 77.595 1.00 36.50 O
ATOM 646 N CYS 222 39.554 17.557 77.479 1.00 35.75 N
ATOM 647 CA CYS 222 39.926 16.225 77.013 1.00 34.30 C
ATOM 648 CB CYS 222 40.886 16.353 75.832 1.00 34.91 C
ATOM 649 SG CYS 222 40.348 17.530 74.587 1.00 34.27 S
ATOM 650 C CYS 222 40.557 15.304 78.048 1.00 33.58 C
ATOM 651 O CYS 222 41.518 15.673 78.723 1.00 32.10 O
ATOM 652 N PHE 223 40.023 14.090 78.145 1.00 32.81 N
ATOM 653 CA PHE 223 40.536 13.082 79.071 1.00 31.67 C
ATOM 654 CB PHE 223 39.483 12.748 80.133 1.00 32.71 C
ATOM 655 CG PHE 223 39.219 13.866 81.096 1.00 33.11 C
ATOM 656 CDl PHE 223 40.194 14.255 82.012 1.00 33.94 C
ATOM 657 CD2 PHE 223 38.006 14.537 81.085 1.00 32.22 C
ATOM 658 CEl PHE 223 39.959 15.290 82.896 1.00 33.16 C
ATOM 659 CE2 PHE 223 37.765 15.572 81.965 1.00 31.76 C
ATOM 660 CZ PHE 223 38.741 15.950 82.873 1.00 33.12 C
ATOM 661 C PHE 223 40.906 11.816 78.299 1.00 29.94 C
ATOM 662 O PHE 223 40.040 11.171 77.709 1.00 30.00 O
ATOM 663 N VAL 224 42.191 11.469 78.306 1.00 27.77 N
ATOM 664 CA VAL 224 42.665 10.289 77.600 1.00 27.02 C
ATOM 665 CB VAL 224 44.062 10.533 77.019 1.00 27.89 C
ATOM 666 CGl VAL 224 44.448 9.400 76.087 1.00 25.54 C
ATOM 667 CG2 VAL 224 44.072 11.857 76.275 1.00 28.48 C
ATOM 668 C VAL 224 42.690 9.085 78.531 1.00 26.58 C
ATOM 669 O VAL 224 43.504 9.010 79.442 1.00 27.42 O
ATOM 670 N MET 225 41.792 8.140 78.281 1.00 25.08 N
ATOM 671 CA MET 225 41.663 6.949 79.114 1.00 25.02 C
ATOM 672 CB MET 225 40.246 6.886 79.700 1.00 26.49 C
ATOM 673 CG MET 225 39.867 8.075 80.578 1.00 25.57 C
ATOM 674 SD MET 225 38.082 8.169 80.880 1.00 33.54 S
ATOM 675 CE MET 225 37.902 7.211 82.401 1.00 27.55 C
ATOM 676 C MET 225 41.936 5.667 78.346 1.00 24.44 C
ATOM 677 O MET 225 41.976 5.663 77.113 1.00 22.33 O
ATOM 678 N GLU 226 42.116 4.573 79.086 1.00 23.01 N
ATOM 679 CA GLU 226 42.377 3.292 78.458 1.00 23.17 C
ATOM 680 CB GLU 226 42.716 2.216 79.509 1.00 24.98 C
ATOM 681 CG GLU 226 41.564 1.704 80.379 1.00 28.56 C
ATOM 682 CD GLU 226 42.011 0.642 81.404 1.00 29.20 C
ATOM 683 OEl GLU 226 42.292 0.998 82.575 1.00 29.19 O
ATOM 684 OE2 GLU 226 42.093 -0.552 81.034 1.00 27.58 O
ATOM 685 C GLU 226 41.153 2.898 77.647 1.00 24.13 C
ATOM 686 O GLU 226 40.028 3.234 77.999 1.00 21.70 O
ATOM 687 N TYR 227 41.383 2.219 76.532 1.00 25.57 N
ATOM 688 CA TYR 227 40.295 1.782 75.670 1.00 25.99 C
ATOM 689 CB TYR 227 40.815 1.620 74.229 1.00 26.77 C
ATOM 690 CG TYR 227 39.777 1.147 73.238 1.00 26.48 C
ATOM 691 CDl TYR 227 38.571 1.821 73.097 1.00 26.01 C
ATOM 692 CEl TYR 227 37.607 1.383 72.214 1.00 26.56 C
ATOM 693 CD2 TYR 227 39.99-4 0.016 72.459 1.00 25.81 C
ATOM 694 CE2 TYR 227 39.031 -0.436 71.567 1.00 27.15 C
ATOM 695 C2 TYR 227 37.836 0.251 71.450 1.00 27.24 C
ATOM 696 OH TYR 227 36.849 -0.200 70.597 1.00 26.17 O
ATOM 697 C TYR 227 39.724 0.458 76.201 1.00 25.16 C
ATOM 698 O TYR 227 40.463 -0.502 76.405 1.00 25.33 O
ATOM 699 N VAL 228 38.414 0.432 76.440 1.00 24.03 N
ATOM 700 CA VAL 228 37.707 -0.748 76.948 1.00 23.38 C
ATOM 701 CB VAL 228 37.050 -0.431 78.317 1.00 24.16 C
ATOM 702 CGl VAL 228 36.207 -1.600 78.788 1.00 25.19 C
ATOM 703 CG2 VAL 228 38.121 -0.110 79.340 1.00 25.54 C
ATOM 704 C VAL 228 36.618 -1.092 75.926 1.00 24.22 C
ATOM 705 O VAL 228 35.645 -0.351 75.794 1.00 24.70 O
ATOM 706 N ASN 229 36.770 -2.212 75.216 1.00 24.45 N
ATOM 707 CA ASN 229 35.801 -2.584 74.177 1.00 26.38 C
ATOM 708 CB ASN 229 36.524 -2.939 72.878 1.00 27.13 C
ATOM 709 CG ASN 229 37.336 -4.214 72.988 1.00 27.38 C
ATOM 710 ODl ASN 229 37.779 -4.757 71.982 1.00 31.28 O ATOM 711 ND2 ASN 229 37.544 -4.692 74.211 1.00 27.89 N
ATOM 712 C ASN 229 34.809 -3.698 74.475 1.00 26.19 C
ATOM 713 O ASN 229 34.234 -4.283 73.550 1.00 26.44 O
ATOM 714 N GLY 230 34.609 -4.000 75.750 1.00 26.26 N
ATOM 715 CA GLY 230 33.660 -5.036 76.104 1..0000 2 266..1100 C
ATOM 716 C GLY 230 32.252 -4.499 75.957 1..0000 2 255..8822 C
ATOM 717 O GLY 230 31.285 -5.263 75.954 1.00 24.94 O
ATOM 718 N GLY 231 32.149 -3.175 75.825 1.00 25.90 N
ATOM 719 CA GLY 231 30.858 -2.524 75.680 1.00 24.87 C
ATOM 720 C GLY 231 30.272 -2.076 77.008 1.00 25.81 C
ATOM 721 O GLY 231 30.541 -2.674 78.051 1.00 24.57 O
ATOM 722 N GLU 232 29.465 -1.022 76.979 1.00 27.07 N
ATOM 723 CA GLU 232 28.844 -0.524 78.202 1.00 29.02 C
ATOM 724 CB GLU 232 28.127 0.802 77.944 1.00 31.45 C
ATOM 725 CG GLU 232 29.076 1.964 77.644 1 1..0000 3 322..2222 C
ATOM 726 CD GLU 232 28.360 ( 3.301 77.599 1.00 32.73 C
ATOM 727 OEl GLU 232 27.474 3.473 76.727 1.00 32.53 O
ATOM 728 OE2 GLU 232 28.681 4.176 78.437 1.00 33.89 O
ATOM 729 C GLU 232 27.871 -1.555 78.753 1.00 30.54 C
ATOM 730 O GLU 232 27.159 -2.220 77.999 1.00 32.14 O
ATOM 731 N LEU 233 27.849 -1.680 80.073 1.00 29.69 N
ATOM 732 CA LEU 233 27.008 -2.649 80.752 1.00 30.25 C
ATOM 733 CB LEU 233 27.470 -2.752 82.202 1.00 29.42 C
ATOM 734 CG LEU 233 27.145 -4.033 82.957 1.00 28.70 C
ATOM 735 CDl LEU 233 25.649 -4.106 83.153 1.00 30.58 C
ATOM 736 CD2 LEU 233 27.670 -5.246 82.188 1.00 26.93 C
ATOM 737 C LEU 233 25.509 -2.312 80.682 1.00 32.27 C
ATOM 738 O LEU 233 24.656 -3.200 80.607 1.00 31.70 O
ATOM 739 N PHB 234 25.196 -1.024 80.702 1.00 33.60 N
ATOM 740 CA PHE 234 23.813 -0.581 80.633 1.00 35.49 C
ATOM 741 CB PHE 234 23.768 0.955 80.611 1.00 36.90 C
ATOM 742 CG PHE 234 22.463 1.523 80.116 1.00 39.95 C
ATOM 743 CDl PHE 234 22.120 1.441 78.771 1.00 40.82 C
ATOM 744 CD2 PHE 234 21.580 2.142 80.993 1.00 40.96 C
ATOM 745 CEl PHE 234 20.913 1.970 78.305 1.00 43.63 C
ATOM 746 CE2 PHE 234 20.371 2.673 80.540 1.00 42.61 C
ATOM 747 CZ PHE 234 20.033 2.588 79.195 1.00 42.42 C
ATOM 748 C PHE 234 23.116 -1.164 79.404 1.00 34.57 C
ATOM 749 O PHE 234 21.908 -1.395 79.411 1.00 33.82 O
ATOM 750 N PHE 235 23.891 -1.427 78.357 1.00 34.77 N
ATOM 751 CA PHE 235 23.341 -1.971 77.124 1.00 34.63 C
ATOM 752 CB PHE 235 24.240 -1.576 75.950 1.00 36.17 C
ATOM 753 CG PHE 235 24.193 -0.103 75.638 1.00 40.72 C
ATOM 754 CDl PHE 235 25.350 0.601 75.313 1.00 41.48 C
ATOM 755 CD2 PHE 235 22.987 0.591 75.699 1.00 40.72 C
ATOM 756 CEl PHE 235 25.303 1.972 75.061 1.00 41.80 C
ATOM 757 CE2 PHE 235 22.935 1.962 75.446 1.00 41.92 C
ATOM 758 CZ PHE 235 24.092 652 75.129 1.00 41.37 C
ATOM 759 C PHE 235 23.151 -3.476 77.186 1.00 34.06 C
ATOM 760 O PHE 235 22.177 -4.012 76.638 1.00 34.78 O
ATOM 761 N HIS 236 24.070 -4.172 77.843 1.00 32.47 N
ATOM 762 CA HIS 236 23.920 -5.615 77.964 1.00 33.58 C
ATOM 763 CB HIS 236 25.113 -6.226 78.693 1.00 32.09 C
ATOM 764 CG HIS 236 26.405 -6.096 77.947 1.00 31.43 C
ATOM 765 CD2 HIS 236 27.500 -5.338 78.190 1.00 31.29 C
ATOM 766 NDl HIS 236 26.686 -6.823 76.811 1.00 31.85 N
ATOM 767 CEl HIS 236 27.901 -6.524 76.389 1.00 32.07 C
ATOM 768 NE2 HIS 236 28.417 -5.624 77.209 1.00 31.31 N
ATOM 769 C HIS 236 22.647 -5.830 78.764 1.00 33.24 C
ATOM 770 O HIS 236 21.663 -6.369 78.261 1.00 34.16 O
ATOM 771 N LEU 237 22.651 -5.366 80.006 1.00 33.86 N
ATOM 772 CA LEU 237 21.473 -5.516 80.845 1.00 33.82 C
ATOM 773 CB LEU 237 21.570 -4.628 82.080 1.00 30.63 C
ATOM 774 CG LEU 237 20.396 -4.820 83.045 1.00 30.44 C
ATOM 775 CDl LEU 237 20.407 -6.256 83.573 1.00 28.13 C
ATOM 776 CD2 LEU 237 20.486 -3.823 84.195 1.00 29.42 C
ATOM 111 C LEU 237 20.213 -5.144 80.072 1.00 35.17 C
ATOM 778 O LEU 237 19.224 -5.876 80.111 1.00 34.18 O
ATOM 779 N SER 238 20.260 -4.012 79.367 1.00 37.28 N
ATOM 780 CA SER 238 19.106 -3.531 78.607 1.00 40.50 C
ATOM 781 CB SER 238 19.126 -2.004 78.474 1.00 41.28 C
ATOM 782 OG SER 238 20.029 -1.601 77.462 1.00 44.05 O
ATOM 783 C SER 238 19.058 -4.141 77.224 1.00 41.49 C ATOM 784 O SER 238 18.826 -3.445 76.226 1.00 43.25 O
ATOM 785 N ARG 239 19.279 -5.448 77.186 1.00 42.09 N
ATOM 786 CA ARG 239 19.263 -6.243 75.974 1.00 41.36 C
ATOM 787 CB ARG 239 20.650 -6.252 75.325 1.00 44.32 C
ATOM 788 CG ARG 239 20.847 -7.323 74.245 1.00 47.18 C
ATOM 789 CD ARG 239 20.957 -8.737 74.840 1.00 50.09 C
ATOM 790 NE ARG 239 22.191 -8.923 75.609 1.00 52.82 N
ATOM 791 CZ ARG 239 23.377 -9.227 75.078 1.00 53.76 C
ATOM 792 NHl ARG 239 23.500 -9.392 73.761 1.00 53.79 N
ATOM 793 NH2 ARG 239 24.447 -9.342 75.864 1.00 53.93 N
ATOM 794 C ARG 239 18.905 -7.632 76.470 1.00 40.59 C
ATOM 795 O ARG 239 18.404 -8.473 75.722 1.00 41.15 O
ATOM 796 N GLU 240 19.165 -7.866 77.750 1.00 38.41 N
ATOM 797 CA GLU 240 18.868 -9.150 78.354 1.00 36.87 C
ATOM 798 CB GLU 240 20.150 -9.760 78.911 1.00 38.74 C
ATOM 799 CG GLU 240 21.346 -9.524 78.006 1.00 41.42 C
ATOM 800 CD GLU 240 22.574 -10.260 78.460 1.00 42.96 C
ATOM 801 OEl GLU 240 22.758 -10.393 79.690 1.00 45.61 O
ATOM 802 OE2 GLU 240 23.366 -10.692 77.592 1.00 44.85 O
ATOM 803 C GLU 240 17.842 -8.966 79.466 1.00 35.43 C
ATOM 804 O GLU 240 17.429 -9.936 80.096 1.00 35.00 O
ATOM 805 N ARG 241 17.436 -7.714 79.689 1.00 34.34 N
ATOM 806 CA ARG 241 16.457 -7.352 80.719 1.00 34.89 C
ATOM 807 CB ARG 241 15.156 -8.165 80.568 1.00 36.72 C
ATOM 808 CG ARG 241 14.426 -8.081 79.219 1.00 40.04 C
ATOM 809 CD ARG 241 14.064 -6.652 78.829 1.00 42.33 C
ATOM 810 NE ARG 241 15.106 -6.052 78.007 1.00 44.23 N
ATOM 811 CZ ARG 241 15.690 -4.885 78.263 1.00 45.99 C
ATOM 812 NHl ARG 241 15.334 -4.170 79.328 1.00 45.03 N
ATOM 813 NH2 ARG 241 16.648 -4.446 77.462 1.00 45.83 N
ATOM 814 C ARG 241 16.986 -7.560 82.148 1.00 33.77 C
ATOM 815 O ARG 241 16.900 -6.666 82.996 1.00 34.63 O
ATOM 816 N VAL 242 17.536 -8.742 82.405 1.00 31.82 N
ATOM 817 CA VAL 242 18.036 -9.087 83.726 1.00 30.52 C
ATOM 818 CB VAL 242 16.898 -9.738 84.547 1.00 32.05 C
ATOM 819 CGl VAL .242 16.376 -10.973 83.829 1.00 31.29 C
ATOM 820 CG2 VAL 242 17.384 -10.096 85.942 1.00 33.85 C
ATOM 821 C VAL 242 19.234 -10.043 83.648 1.00 29.52 C
ATOM 822 O VAL 242 19.445 -10.698 82.631 1.00 29.86 O
ATOM 823 N PHE 243 20.037 -10.097 84.709 1.00 27.72 N
ATOM 824 CA PHE 243 21.189 -11.000 84.752 1.00 26.69 C
ATOM 825 CB PHE 243 22.474 -10.269 85.154 1.00 25.65 C
ATOM 826 CG PHE 243 22.965 -9.271 84.138 1.00 27.26 C
ATOM 827 CDl PHE 243 22.690 -9.435 82.787 1.00 24.80 C
ATOM 828 CD2 PHE 243 23.735 -8.190 84.535 1.00 25.26 C
ATOM 829 CEl PHE 243 23.174 -8.541 81.853 1.00 25.15 C
ATOM 830 CE2 PHE 243 24.226 -7.289 83.610 1.00 27.38 C
ATOM 831 CZ PHE 243 23.945 -7.464 82.260 1.00 26.77 C
ATOM 832 C PHE 243 20.913 -12.067 85.795 1.00 27.32 C
ATOM 833 O PHE 243 20.053 -11.883 86.659 1.00 27.65 O
ATOM 834 N SER 244 21.635 -13.182 85.727 1.00 26.40 N
ATOM 835 CA SER 244 21.442 -14.229 86.716 1.00 26.19 C
ATOM 836 CB SER 244 22.050 -15.560 86.248 1.00 26.33 C
ATOM 837 OG SER 244 23.465 -15.515 86.218 1.00 29.46 O
ATOM 838 C SER 244 22.134 -13.732 87.986 1.00 25.81 C
ATOM 839 O SER 244 22.910 -12.772 87.934 1.00 24.18 O
ATOM 840 N GLU 245 21.849 -14.369 89.121 1.00 24.92 N
ATOM 841 CA GLU 245 22.451 -13.944 90.381 1.00 26.20 C
ATOM 842 CB GLU 245 21.911 -14.768 91.561 1.00 26.00 C
ATOM 843 CG GLU 245 20.394 -14.861 91.623 1.00 26.76 C
ATOM 844 CD GLU 245 19.839 -14.799 93.038 1.00 29.84 C
ATOM 845 OEl GLU 245 20.585 -15.080 94.007 1.00 30.83 O
ATOM 846 OE2 GLU 245 18.642 -14.474 93.185 1.00 31.58 O
ATOM 847 C GLU 245 23.956 -14.100 90.289 1.00 25.35 C
ATOM 848 O GLU 245 24.713 -13.261 90.758 1.00 23.71 O
ATOM 849 N ASP 246 24.379 -15.181 89.653 1.00 26.00 N
ATOM 850 CA ASP 245 25.791 -15.464 89.500 1.00 26.52 C
ATOM 851 CB ASP 246 25.967 -16.836 88.874 1.00 30.28 C
ATOM 852 CG ASP 246 26.812 -17.737 89.723 1.00 35.62 C
ATOM 853 ODl ASP 246 28.024 -17.446 89.864 1.00 36.95 O
ATOM 854 OD2 ASP 246 26.258 -18.728 90.261 1.00 38.71 O
ATOM 855 C ASP 246 26.530 -14.423 88.667 1.00 25.92 C
ATOM 856 O ASP 246 27.644 -14.021 89.020 1.00 22.99 O ATOM 857 N ARG 247 25.926 -14.003 87.554 1.00 24.05 N
ATOM 858 CA ARG 247 26.570 -13.007 86.719 1.00 23.48 C
ATOM 859 CB ARG 247 25.758 -12.725 85.459 1.00 25.25 C
ATOM 860 ,CG ARG 247 26.461 -11.748 84.534 1.00 25.19 C
ATOM 861 CD ARG 247 25.857 -11.713 83.144 1.00 26.11 C
ATOM 862 NE ARG 247 26.567 -10.762 82.293 1.00 28.53 N
ATOM 863 CZ ARG 247 26.163 -10.368 81.089 1.00 27.29 C
ATOM 864 NHl ARG 247 25.037 -10.842 80.576 1.00 27.31 N
ATOM 865 NH2 ARG 247 26.895 -9.505 80.396 1.00 25.93 N
ATOM 866 C ARG 247 26.686 -11.746 87.565 1.00 24.94 C
ATOM 867 O ARG 247 27.737 -11.101 87.600 1.00 24.43 O
ATOM 868 N THR 248 25.603 -11.411 88.263 1.00 22.80 N
ATOM 869 CA THR 248 25.610 -10.244 89.124 1.00 21.00 C
ATOM 870 CB THR 248 24.224 -9.985 89.729 1.00 21.45 C
ATOM 871 OGl THR 248 23.260 -9.818 88.682 1.00 19.75 O
ATOM 872 CG2 THR 248 24.254 -8.722 90.593 1.00 21.24 C
ATOM 873 C THR 248 26.637 -10.427 90.258 1.00 22.09 C
ATOM 874 O THR 248 27.322 -9.474 90.640 1.00 22.39 O
ATOM 875 N ARG 249 26.755 -11.639 90.798 1.00 18.61 N
ATOM 876 CA ARG 249 27.733 -11.872 91.858 1.00 19.35 C
ATOM 877 CB ARG 249 27.681 -13.322 92.344 1.00 20.68 C
ATOM 878 CG ARG 249 28.844 -13.727 93.255 1.00 22.59 C
ATOM 879 CD ARG 249 28.418 -14.840 94.191 1.00 25.85 C
ATOM 880 NE ARG 249 27.523 -15.740 93.471 1.00 30.68 N
ATOM 881 CZ ARG 249 26.312 -16.107 93.875 1.00 27.79 C
ATOM 882 NHl ARG 249 25.810 -15.670 95.024 1.00 25.86 N
ATOM 883 NH2 ARG 249 25.589 -16.895 93.096 1.00 28.35 N
ATOM 884 C ARG 249 29.145 -11.538 91.369 1.00 18.55 C
ATOM 885 O ARG 249 29.924 -10.920 92.087 1.00 16.93 O
ATOM 886 N PHE 250 29.449 -11.950 90.142 i.oo 18.28 N
ATOM 887 CA PHE 250 30.740 -11.709 89.509 1.00 17.90 C
ATOM 888 CB PHE 250 30.751 -12.349 88.122 1.00 18.41 C
ATOM 889 CG PHE 250 31.961 -12.010 87.307 1.00 22.82 C
ATOM 890 CDl PHE 250 33.147 -12.712 87.468 1.00 23.76 C
ATOM 891 CD2 PHE 250 31.930 -10.960 86.398 1.00 24.77 C
ATOM 892 CEl PHE 250 34.275 -12.374 86.741 1.00 22.72 C
ATOM 893 CE2 PHE 250 33.056 -10.620 85.672 1.00 23.88 C
ATOM 894 CZ PHE 250 34.228 -11.327 85.844 1.00 23.96 C
ATOM 895 C PHE 250 31.056 -10.209 89.376 1.00 19.63 C
ATOM 896 O PHE 250 32.129 -9.749 89.768 1.00 21.18 O
ATOM 897 N TYR 251 30.125 -9.442 88.818 1.00 19.81 N
ATOM 898 CA TYR 251 30.363 -8.019 88.647 1.00 21.03 C
ATOM 899 CB TYR 251 29.249 -7.364 87.810 1.00 21.82 C
ATOM 900 CG TYR 251 29.177 -7.863 86.379 1.00 22.62 C
ATOM 901 CDl TYR 251 30.336 -8.152 85.665 1.00 21.22 C
ATOM 902 CEl TYR 251 30.279 -8.615 84.362 1.00 22.62 C
ATOM 903 CD2 TYR 251 27.951 -8.047 85.744 1.00 21.78 C
ATOM 904 CE2 TYR 251 27.883 -8.510 84.441 1.00 22.02 C
ATOM 905 CZ TYR 251 29.050 -8.796 83.755 1.00 22.28 C
ATOM 906 OH TYR 251 28.993 -9.306 82.481 1.00 22.22 O
ATOM 907 C TYR 251 30.464 -7.340 89.999 1.00 19.73 C
ATOM 908 O TYR 251 31.327 -6.500 90.208 1.00 21.34 O
ATOM 909 N GLY 252 29.576 -7.718 90.910 1.00 18.80 N
ATOM 910 CA GLY 252 29.573 -7.137 92.238 1.00 19.37 C
ATOM 911 C GLY 252 30.877 -7.384 92.969 1.00 20.13 C
ATOM 912 O GLY 252 31.385 -6.503 93.667 1.00 19.10 O
ATOM 913 N ALA 253 31.413 -8.591 92.817 1.00 19.02 N
ATOM 914 CA ALA 253 32.672 -8.941 93.453 1.00 18.48 C
ATOM 915 CB ALA 253 33.045 -10.361 93.114 1.00 17.73 C
ATOM 916 C ALA 253 33.779 -7.982 93.000 1.00 19.31 C
ATOM 917 O ALA 253 34.482 -7.400 93.831 1.00 19.09 O
ATOM 918 N GLU 254 33.910 -7.804 91.688 1.00 19.27 N
ATOM 919 CA GLU 254 34.935 -6.923 91.137 1.00 21.25 C
ATOM 920 CB GLU 254 34.998 -7.064 .89.619 1.00 21.56 C
ATOM 921 CG GLU 254 35.118 -8.501 89.164 1.00 23.81 C
ATOM 922 CD GLU 254 35.643 -8.632 87.749 1.00 24.82 C
ATOM 923 OEl GLU 254 35.153 -7.923 86.852 1.00 24.37 O
ATOM 924 OE2 GLU 254 36.551 -9.460 87.537 1.00 29.23 O
ATOM 925 C GLU 254 34.714 -5.463 91.518 1.00 21.39 C
ATOM 926 O GLU 254 35.668 -4.692 91.639 1.00 22.57 O
ATOM 927 N ILE 255 33.456 -5.086 91.711 1.00 20.27 N
ATOM 928 CA ILE 255 33.127 -3.724 92.109 1.00 18.15 C
ATOM 929 CB ILE 255 31.615 -3.466 91.983 1.00 19.44 C ATOM 930 CG2 ILE 255 31.244 -2.196 92.735 1.00 16.01 C
ATOM 931 CGl ILE 255 31.231 -3.417 90.492 1.00 18.71 C
ATOM 932 CDl ILE 255 29.764 -3.264 90.208 1.00 12.90 C
ATOM 933 C ILE 255 33.561 -3.512 93.557 1.00 19.33 C
ATOM 934 O ILE 255 34.127 -2.472 93.911 1.00 18.20 O
ATOM 935 N VAL 256 33.292 -4.509 94.393 1.00 19.57 N
ATOM 936 CA VAL 256 33.677 -4.440 95.786 1.00 18.16 C
ATOM 937 CB VAL 256 33.194 -5.692 96.552 1.00 18.31 C
ATOM 938 CGl VAL 256 33.804 -5.735 97.948 1.00 17.40 C
ATOM 939 CG2 VAL 256 31.674 -5.688 96.636 1.00 18.01 C
ATOM 940 C VAL 256 35.203 -4.342 95.849 1.00 19.41 C
ATOM 941 O VAL 256 35.741 -3.581 96.644 1.00 18.30 O
ATOM 942 N SER 257 35.893 -5.088 94.990 1.00 20.10 N
ATOM 943 CA SER 257 37.354 -5.071 94.982 1.00 20.74 C
ATOM 944 CB SER 257 37.899 -6.003 93.903 1.00 21.16 C
ATOM 945 OG SER 257 39.317 -6.024 93.928 1.00 24.08 O
ATOM 946 C SER 257 37.871 -3.656 94.749 1.00 21.39 C
ATOM 947 O SER 257 38.719 -3.170 95.491 1.00 20.47 O
ATOM 948 N ALA 258 37.341 -2.994 93.726 1.00 21.10 N
ATOM 949 CA ALA 258 37.750 -1.633 93.416 1.00 20.60 C
ATOM 950 CB ALA 258 37.118 -1.186 92.107 1.00 18.73 C
ATOM 951 C ALA 258 37.395 -0.651 94.547 1.00 22.35 C
ATOM 952 O ALA 258 38.221 0.179 94.916 1.00 20.97 O
ATOM 953 N LEU 259 36.179 -0.743 95.091 1.00 23.90 N
ATOM 954 CA LEU 259 35.770 0.148 96.179 1.00 23.63 C
ATOM 955 CB LEU 259 34.305 -0.085 96.572 1.00 23.80 C
ATOM 956 CG LEU 259 33.216 0.342 95.578 1.00 24.68 C
ATOM 957 CDl LEU 259 31.866 0.393 96.289 1.00 26.36 C
ATOM 958 CD2 LEU 259 33.536 1.715 95.001 1.00 26.36 C
ATOM 959 C LEU 259 36.675 -0.036 97.403 1.00 24.16 C
ATOM 960 O LEU 259 37.125 0.937 98.002 1.00 24.81 O
ATOM 961 N ASP 260 36.942 -1.282 97.769 1.00 23.59 N
ATOM 962 CA ASP 260 37.820 -1.563 98.899 1.0O 24.63 C
ATOM 963 CB ASP 260 38.127 -3.064 98.961 1.00 25.38 C
ATOM 964 CG ASP 260 38.913 -3.463 100.205 1.00 26.14 C
ATOM 965 ODl ASP 260 39.082 -2.636 101.123 1.00 26.02 O
ATOM 966 OD2 ASP 260 39.356 -4.627 100.272 1.00 26.53 O
ATOM 967 C ASP 260 39.118 -0.785 98.700 1.00 25.37 C
ATOM 968 O ASP 260 39.623 -0.144 99.623 1.00 25.96 O
ATOM 969 N TYR 261 39.651 -0.844 97.482 1.00 25.75 N
ATOM 970 CA TYR 261 40.887 -0.158 97.150 1.00 25.78 C
ATOM 971 CB TYR 261 41.249 -0.421 95.699 1.00 26.91 C
ATOM 972 CG TYR 261 42.305 0.519 95.172 1.00 28.44 C
ATOM 973 CDl TYR 261 43.637 0.369 95.532 1.00 30.66 C
ATOM 974 CEl TYR 261 44.612 1.227 95.044 1.00 32.66 C
ATOM 975 CD2 TYR 261 41.971 1.555 94.315 1.00 27.95 C
ATOM 976 CE2 TYR 261 42.931 2.412 93.822 1.00 29.55 C
ATOM 977 CZ TYR 261 44.252 2.245 94.187 1.00 31.59 C
ATOM 978 OH TYR 261 45.220 3.088 93.677 1.00 34.54 O
ATOM 979 C TYR 261 40.835 1.353 97.372 1.00 26.16 C
ATOM 980 O TYR 261 41.685 1.916 98.066 1.00 25.63 O
ATOM 981 N LEU 262 39.840 2.003 96.772 1.00 25.53 N
ATOM 982 CA LEU 262 39.689 3.449 96.887 1.00 25.59 C
ATOM 983 CB LEU 262 38.530 3.930 96.022 1.00 26.58 C
ATOM 984 CG LEU 262 38.787 3.991 94.514 1.00 26.68 C
ATOM 985 CDl LEU 262 37.508 4.411 93.801 1.00 25.01 C
ATOM 986 CD2 LEU 262 39.909 4.999 94.222 1.00 25.65 C
ATOM 987 C LEU 262 39.484 3.920 98.314 1.00 25.90 C
ATOM 988 O LEU 262 40.035 4.934 98.719 1.00 25.97 O
ATOM 989 N HIS 263 38.680 3.181 99.068 1.00 26.22 N
ATOM 990 CA HIS 263 38.402 3.518 100.455 1.00 27.02 C
ATOM 991 CB HIS 263 37.287 2.623 101.011 1.00 25.14 C
ATOM 992 CG HIS 263 35.948 2.873 100.394 1.00 23.13 C
ATOM 993 CD2 HIS 263 35.552 3.763 99.455 1.00 21.66 C
ATOM 994 NDl HIS 263 34.821 2.166 100.751 1.00 21.57 N
ATOM 995 CEl HIS 263 33.789 2.610 100.059 1.00 21.90 C
ATOM 996 NE2 HIS 263 34.205 3.579 99.265 1.00 21.87 N
ATOM 997 C HIS 263 39.646 3.345 101.312 1.00 28.91 C
ATOM ' 998 O HIS 263 39.812 4.035 102.324 1.00 29.49 O
ATOM 999 N SER 264 40.509 2.410 100.931 1.00 30.21 N
ATOM 1000 CA SER 264 41.723 2.187 101.704 1.00 33.01 C
ATOM 1001 CB SER 264 42.498 0.975 101.181 1.00 34.16 C
ATOM 1002 OG SER 264 43.037 1.237 99.897 1.00 40.10 O ATOM 1003 C SER 264 42.558 3.450 101.558 1.00 32.51 C
ATOM 1004 O SER 264 43.289 3.833 102.469 1.00 33.68 O
ATOM 1005 N GLY 265 42.421 4.104 100.408 1.00 31.48 N
ATOM IOOS CA GLY 265 43.153 5.334 100.170 1.00 30.82 C
ATOM 1007 C GLY 265 42.337 6.512 100.663 1.00 31.04 C
ATOM 1008 O GLY 265 42.678 7.S68 100.422 1.00 29.97 O
ATOM 1009 N LYS 266 41.237 6.210 101.343 1.00 31.23 N
ATOM 1010 CA LYS 266 40.352 7.238 101.880 1.00 32.07 C
ATOM 1011 CB LYS 266 41.166 8.244 102.705 1.00 33.74 C
ATOM 1012 CG LYS 266 42.019 7.606 103.793 1.00 36.34 C
ATOM 1013 CD LYS 266 43.497 7.887 103.544 1.00 41.77 C
ATOM 1014 CE LYS 266 44.387 7.411 104.693 1.00 43.76 C
ATOM 1015 NZ LYS 266 45.815 7.863 104.513 1.00 44.71 N
ATOM 1016 C LYS 266 39.541 7.979 100.807 1.00 31.61 C
ATOM 1017 O LYS 266 39.053 9.081 101.046 1.00 31.59 O
ATOM 1018 N ILE 267 39.387 7.375 99.631 1.00 31.38 N
ATOM 1019 CA ILE 267 38.619 8.003 98.560 1.00 30.34 C
ATOM 1020 CB ILE 267 39.284 7.820 97.176 1.00 31.12 C
ATOM 1021 CG2 ILE 267 38.319 8.265 96.070 1.00 30.78 C
ATOM 1022 CGl ILE 267 40.577 8.640 97.104 1.00 32.06 C
ATOM 1023 CDl ILE 267 41.222 8.653 95.737 1.00 33.37 C
ATOM 1024 C ILE 267 37.211 7.444 98.464 1.00 29.92 C
ATOM 1025 O ILE 267 37.002 6.237 98.565 1.00 30.27 O
ATOM 1026 N VAL 268 36.251 8.340 98.263 1.00 29.02 N
ATOM 1027 CA VAL 268 34.845 7.970 98.120 1.00 27.20 C
ATOM 1028 CB VAL 268 33.943 8.846 99.007 1.00 27.25 C
ATOM 1029 CGl VAL 268 32.507 8.327 98.957 1.00 28.81 C
ATOM 1030 CG2 VAL 268 34.466 8.856 100.443 1.00 23.77 C
ATOM 1031 C VAL 268 34.539 8.233 96.651 1.00 27.89 C
ATOM 1032 O VAL 268 34.735 9.347 96.166 1.00 27.01 O
ATOM 1033 N TYR 269 34.070 7.208 95.945 1.00 27.12 N
ATOM 1034 CA TYR 269 33.800 7.321 94.519 1.00 26.40 C
ATOM 1035 CB TYR 269 33.636 5.927 93.904 1.00 26.60 C
ATOM 1036 CG TYR 269 33.844 5.924 92.409 1.00 28.35 C
ATOM 1037 CDl TYR 269 35.086 6.228 91.870 1.00 26.78 C
ATOM 1038 CEl TYR 269 35.272 6.317 90.505 1.00 29.07 C
ATOM 1039 CD2 TYR 269 32.782 5.698 91.529 1.00 29.12 C
ATOM 1040 CE2 TYR 269 32.958 5.787 90.151 1.00 28.61 C
ATOM 1041 CZ TYR 269 34.206 6.099 89.644 1.00 30.19 C
ATOM 1042 OH TYR 269 34.409 6.209 88.274 1.00 34.40 O
ATOM 1043 C TYR 269 32.604 8.192 94.160 1.00 27.35 C
ATOM 1044 O TYR 269 32.636 8.904 93.164 1.00 27.04 O
ATOM 1045 N ARG 270 31.542 8.111 94.956 1.00 28.10 N
ATOM 104S CA ARG 270 30.345 8.919 94.740 1.00 30.37 C
ATOM 1047 CB ARG 270 30.695 10.406 94.911 1.00 31.63 C
ATOM 1048 CG ARG 270 30.819 10.843 96.366 1.00 36.23 C
ATOM 1049 CD ARG 270 31.482 12.229 96.523 1.00 38.78 C
ATOM 1050 NE ARG 270 30.955 13.224 95.591 1.00 40.94 N
ATOM 1051 CZ ARG 270 31.193 14.536 95.670 1.00 42.14 C
ATOM 1052 NHl ARG 270 31.953 15.022 96.651 1.00 42.15 N
ATOM 1053 NH2 ARG 270 30.680 15.364 94.761 1.00 39.90 N
ATOM 1054 C ARG 270 29.583 8.737 93.427 1.00 29.94 C
ATOM 1055 O ARG 270 28.404 9.063 93.353 1.00 29.59 O
ATOM 1056 N ASP 271 30.235 8.220 92.395 1.00 30.32 N
ATOM 1057 CA ASP 271 29.560 8.055 91.111 1.00 30.27 C
ATOM 1058 CB ASP 271 30.342 8.769 90.009 1.00 31.00 C
ATOM 1059 CG ASP 271 30.673 10.205 90.367 1.00 33.47 C
ATOM 1060 ODl ASP 271 29.747 10.938 90.788 1.00 34.39 O
ATOM 1061 OD2 ASP 271 31.856 10.597 90.224 1.00 33.72 O
ATOM 1062 C ASP 271 29.343 6.609 90.688 1.00 30.42 C
ATOM 1063 O ASP 271 29.345 6.313 89.499 1.00 30.03 O
ATOM 1064 N LEU 272 29.169 5.702 91.641 1.00 27.95 N
ATOM 1065 CA LEU 272 28.944 4.321 91.266 1.00 28.08 C
ATOM 1066 CB LEU 272 29.202 3.374 92.435 1.00 28.55 C
ATOM 1067 CG LEU 272 28.779 1.939 92.103 1.00 31.01 C
ATOM 1068 CDl LEU 272 29.495 1.499 90.839 1.00 30.73 C
ATOM 1069 CD2 LEU 272 29.075 0.992 93.271 1.00 31.45 C
ATOM 1070 C LEU 272 27.505 4.176 90.801 1.00 28.61 C
ATOM 1071 O LEU 272 26.575 4.163 91.606 1.00 28.22 O
ATOM 1072 N LYS 273 27.329 4.078 89.492 1.00 27.70 N
ATOM 1073 CA LYS 273 26.009 3.930 88.906 1.00 28.25 C
ATOM 1074 CB LYS 273 25.381 5.318 88.651 1.00 29.29 C
ATOM 1075 CG LYS 273 26.140 6.192 87.673 1.00 31.51 C ATOM 1076 CD LYS 273 25.397 7.491 87.330 1.00 33.12 C
ATOM 1077 CE LYS 273 25.901 8.684 88.129 1.00 34.70 C
ATOM 1078 NZ LYS 273 25.499 8.687 89.575 1.00 40.00 N
ATOM 1079 C LYS 273 26.155 3.136 87.604 1.00 27.62 C
ATOM 1080 O LYS 273 27.159 3.264 86.897 1.00 26.23 O
ATOM 1081 N LEU 274 25.154 2.314 87.304 1.00 27.21 N
ATOM 1082 CA LEU 274 25.152 1.473 86.110 1.00 28.53 C
ATOM 1083 CB LEU 274 23.725 1.006 85.804 1.00 27.70 C
ATOM 1084 CG LEU 274 23.544 0.196 84.513 1.00 28.27 C
ATOM 1085 CDl LEU 274 24.226 -1.159 84.653 1.00 24.52 C
ATOM 1086 CD2 LEU 274 22.052 0.019 84.225 1.00 27.61 C
ATOM 1087 C LEU 274 25.753 2.092 84.843 1.00 29.99 C
ATOM 1088 O LEU 274 26.570 1.468 84.168 1.00 29.88 O
ATOM 1089 N GLU 275 25.348 3.314 84.517 1.00 30.60 N
ATOM 1090 CA GLU 275 25.842 3.975 83.317 1.00 30.91 C
ATOM 1091 CB GLU 275 25.088 5.295 83.115 1.00 32.18 C
ATOM 1092 CG GLU 275 23.576 5.177 83.272 1.00 34.86 C
ATOM 1093 CD GLU 275 23.144 5.241 84.732 1.00 37.73 C
ATOM 1094 OEl GLU 275 23.310 6.321 85.353 1.00 39.16 O
ATOM 1095 OE2 GLU 275 22.648 4.218 85.261 1.00 37.37 O
ATOM 1096 C GLU 275 27.366 4.213 83.316 1.00 30.52 C
ATOM 1097 O GLU 275 27.939 4.589 82.288 1.00 29.88 O
ATOM 1098 N ASN 276 28.016 3.989 84.457 1.00 29.43 N
ATOM 1099 CA ASN 276 29.465 4.164 84.565 1.00 29.18 C
ATOM 1100 CB ASN 276 29.829 4.939 85.833 1.00 29.69 C
ATOM 1101 CG ASN 276 29.443 6.406 85.759 1.00 34.03 C
ATOM 1102 ODl ASN 276 29.831 7.119 84.833 1.00 32.58 O
ATOM 1103 ND2 ASN 276 28.678 6.867 86.744 1.00 34.37 N
ATOM 1104 C ASN 276 30.208 2.825 84.580 1.00 28.88 C
ATOM 1105 O ASN 276 31.409 2.775 84.879 1.00 30.41 O
ATOM 1106 N LEU 277 29.507 1.737 84.270 1.00 26.09 N
ATOM 1107 CA LEU 277 30.146 0.422 84.254 1.00 26.15 C
ATOM 1108 CB LEU 277 29.322 -0.578 85.055 1.00 25.15 C
ATOM 1109 CG LEU 277 29.022 -0.196 86.503 1.00 25.56 C
ATOM 1110 CDl LEU 277 28.103 -1.257 87.100 1.00 23.39 . C
ATOM 1111 CD2 LEU 277 30.313 -0.069 87.299 1.00 24.46 C
ATOM 1112 C LEU 277 30.340 -0.111 82.837 1.00 26.09 C
ATOM 1113 O LEU 277 29.413 -0.089 82.026 1.00 25.08 O
ATOM 1114 N MET 278 31.549 -0.587 82.553 1.00 25.27 N
ATOM 1115 CA MET 278 31.884 -1.136 81.244 1.00 26.52 C
ATOM 1116 CB MET 278 32.806 -0.183 80.488 1.00 28.31 C
ATOM 1117 CG MET 278 32.208 1.164 80.167 1.00 29.97 C
ATOM 1118 SD MET 278 33.346 2.096 79.143 1.00 31.19 S
ATOM 1119 CE MET 278 32.970 1.409 77.500 1.00 30.72 C
ATOM 1120 C MET 278 32.597 -2.479 81.374 1.00 25.07 C
ATOM 1121 O MET 278 33.171 -2.772 82.417 1.00 23.93 O
ATOM 1122 N LEU 279 32.564 -3.280 80.309 1.00 24.28 N
ATOM 1123 CA LEU 279 33.230 -4.581 80.299 1.00 25.35 C
ATOM 1124 CB LEU 279 32.314 -5.672 79.729 1.00 24.54 C
ATOM 1125 CG LEU 279 30.967 -5.963 80.401 1.00 25.49 C
ATOM 1126 CDl LEU 279 30.273 -7.108 79.666 1.00 22.99 C
ATOM 1127 CD2 LEU 279 31.186 -6.325 81.860 1.00 25.24 C
ATOM 1128 C LEU 279 34.476 -4.492 79.432 1.00 25.74 C
ATOM 1129 O LEU 279 34.506 -3.740 78.473 1.00 28.21 O
ATOM 1130 N ASP 280 35.513 -5.247 79.768 1.00 27.83 N
ATOM 1131 CA ASP 280 36.722 -5.224 78.957 1.00 29.37 C
ATOM 1132 CB ASP 280 37.992 -5.326 79.821 1.00 29.84 C
ATOM 1133 CG ASP 280 38.021 -6.574 80.688 1.00 30.99 C
ATOM 1134 ODl ASP 280 37.618 -7.658 80.213 1.00 33.69 O
ATOM 1135 OD2 ASP 280 38.461 -6.473 81.848 1.00 30.31 O
ATOM 1136 C ASP 280 36.672 -6.378 77.968 1.00 28.96 C
ATOM 1137 O ASP 280 35.680 -7.110 77.903 1.00 28.34 O
ATOM 1138 N LYS 281 37.749 -6.524 77.202 1.00 28.63 N
ATOM 1139 CA LYS 281 37.872 -7.565 76.185 1.00 29.82 C
ATOM 1140 CB LYS 281 39.326 -7.626 75.690 1.00 30.90 C
ATOM 1141 CG LYS 281 39.863 -6.267 75.274 1.00 33.88 C
ATOM 1142 CD LYS 281 41.340 -6.279 74.933 1.00 37.74 C
ATOM 1143 CE LYS 281 42.195 -6.556 76.151 1.00 39.54 C
ATOM 1144 NZ LYS 281 41.976 -7.929 76.676 1.00 42.43 N
ATOM 1145 C LYS 281 37.443 -8.937 76.693 1.00 28.69 C
ATOM 1146 O LYS 281 36.631 -9.610 76.064 1.00 30.78 O
ATOM 1147 N ASP 282 37.976 -9.326 77.849 1.00 27.82 N
ATOM 1148 CA ASP 282 37.698 -10.625 78.456 1.00 26.87 C ATOM 1149 CB ASP 282 38.857 -10.990 79.394 1.00 27.19 C
ATOM 1150 CG ASP 282 40.232 -10.805 78.727 1.00 30.95 C
ATOM 1151 ODl ASP 282 40.546 -11.551 77.769 1.00 31.46 O
ATOM 1152 OD2 ASP 282 40.996 -9.900 79.152 1.00 30.80 O
ATOM 1153 C ASP 282 36.357 -10.705 79.206 1.00 26.54 C
ATOM 1154 O ASP 282 35.909 -11.794 79.557 1.00 24.70 O
ATOM 1155 N GLY 283 35.723 -9.555 79.446 1.00 24.70 N
ATOM 1156 CA GLY 283 34.452 -9.544 80.147 1.00 22.49 C
ATOM 1157 C GLY 283 34.519 -9.074 81.593 1.00 23.02 C
ATOM 1158 O GLY 283 33.555 -9.227 82.331 1.00 21.34 O
ATOM 1159 N HIS 284 35.652 -8.509 82.001 1.00 22.66 N
ATOM 1160 CA HIS 284 35.820 -8.007 83.370 1.00 23.68 C
ATOM 1161 CB HIS 284 37.299 -8.037 83.782 1.00 22.54 C
ATOM 1162 CG HIS 284 37.842 -9.417 83.978 1.00 24.71 C
ATOM 1163 CD2 HIS 284 38.679 -10.165 83.219 1.00 25.96 C
ATOM 1164 NDl HIS 284 37.488 -10.210 85.048 1.00 24.67 N
ATOM 1165 CEl HIS 284 38.078 -11.386 84.938 1.00 26.15 C
ATOM 1166 NE2 HIS 284 38.806 -11.386 83.837 1.00 25.53 N
ATOM 1167 C HIS 284 35.291 -6.580 83.490 1.00 23.30 C
ATOM 1168 O HIS 284 35.209 -5.856 82.502 1.00 24.10 O
ATOM 1169 N ILE 285 34.927 -6.187 84.704 1.00 22.95 N
ATOM 1170 CA ILE 285 34.388 -4.856 84.969 1.00 23.46 C
ATOM 1171 CB ILE IBS 33.786 -4.746 86.401 1.00 23.80 C
ATOM 1172 CG2 ILE 285 33.465 -3.289 86.706 1.00 23.54 C
ATOM 1173 CGl ILE 285 32.520 -5.596 86.540 1.00 23.15 C
ATOM 1174 CDl ILE 285 31.246 -4.857 86.209 1.00 20.70 C
ATOM 1175 C ILE 285 35.436 -3.753 84.856 1.00 24.91 C
ATOM 1176 O ILE 285 36.626 -3.966 85.131 1.00 23.60 O
ATOM 1177 N LYS 286 34.966 -2.571 84.471 1.00 24.56 N
ATOM 1178 CA LYS 286 35.801 -1.396 84.339 1.00 25.98 C
ATOM 1179 CB LYS 286 36.349 -1.274 82.915 1.00 27.88 C
ATOM 1180 CG LYS 286 37.714 -1.909 82.736 1.00 29.19 C
ATOM 1181 CD LYS 286 38.791 -1.064 83.406 1.00 32.34 C
ATOM 1182 CE LYS 286 40.099 -1.821 83.537 1.00 34.12 C
ATOM 1183 NZ LYS 286 40.430 -2.575 82.291 1.00 36.37 N
ATOM 1184 C LYS 286 34.958 -0.182 84.681 1.00 26.86 C
ATOM 1185 O LYS 286 34.120 0.253 83.884 1.00 26.80 O
ATOM 1186 N ILE 287 35.175 0.346 85.882 1.00 26.17 N
ATOM 1187 CA ILE 287 34.463 1.521 86.352 1.00 26.31 C
ATOM 1188 CB ILE 287 34.595 1.645 87.864 1.00 27.74 C
ATOM 1189 CG2 ILE 287 33.753 2.798 88.373 1.00 26.57 C
ATOM 1190 CGl ILE 287 34.150 0.330 88.508 1.00 28.12 C
ATOM 1191 CDl ILE 287 34.431 0.232 89.984 1.00 29.55 C
ATOM 1192 C ILE 287 35.092 2.723 85.660 1.00 28.52 C
ATOM 1193 O ILE 287 36.306 2.923 85.729 1.00 27.68 O
ATOM 1194 N THR 288 34.249 3.510 84.993 1.00 29.96 N
ATOM 1195 CA THR 288 34.691 4.670 84.224 1.00 32.42 C
ATOM 1196 CB THR 288 34.309 4.519 82.747 1.00 31.47 C
ATOM 1197 OGl THR 288 34.578 \ 3.181 82.322 1.00 33.16 O
ATOM 1198 CG2 THR 288 35.097 5.491 81.894 1.00 29.93 C
ATOM 1199 C THR 288 34.104 5.997 84.670 1.00 34.00 C
ATOM 1200 O THR 288 32.901 6.116 84.889 1.00 35.78 O
ATOM 1201 N ASP 289 34.950 7.011 84.763 1.00 35.69 N
ATOM 1202 CA ASP 289 34.472 8.319 85.149 1.00 37.81 C
ATOM 1203 CB ASP 289 35.610 9.148 85.738 1.00 39.56 C
ATOM 1204 CG ASP 289 35.613 9.118 87.244 1.00 42.16 C
ATOM 1205 ODl ASP 289 34.511 8.973 87.824 1.00 40.62 O
ATOM 1206 OD2 ASP 289 36.702 9.259 87.843 1.00 43.72 O
ATOM 1207 C ASP 289 33.870 9.062 83.966 1.00 38.18 C
ATOM 1208 O ASP 289 33.857 8.554 82.843 1.00 37.31 O
ATOM 1209 N PHE 290 33.357 10.261 84.246 1.00 38.77 N
ATOM 1210 CA PHE 290 32.774 11.142 83.238 1.00 39.10 C
ATOM 1211 CB PHE 290 33.899 11.762 82.417 1.00 38.01 C
ATOM 1212 CG PHE 290 35.123 12.072 83.220 1.00 36.55 C
ATOM 1213 CDl PHE 290 36.359 11.561 82.848 1.00 37.13 C
ATOM 1214 CD2 PHE 290 35.041 12.871 84.345 1.00 37.44 C
ATOM 1215 CEl PHE 290 37.497 11.842 83.586 1.00 36.80 C
ATOM 1216 CE2 PHE 290 36.176 13.160 85.092 1.00 38.48 C
ATOM 1217 CZ PHE 290 37.409 12.639 84.706 1.00 39.55 C
ATOM 1218 C PHE 290 31.820 10.424 82.302 1.00 40.34 C
ATOM 1219 O PHE 290 31.615 10.851 81.168 1.00 39.25 O
ATOM 1220 N GLY 291 31.240 9.326 82.769 1.00 42.23 N
ATOM 1221 CA GLY 291 30.336 8.587 81.911 1.00 45.05 C ATOM 1222 C GLY 291 28.900 8.942 82.194 1.00 46.85 C
ATOM 1223 O GLY 291 27.983 8.310 81.666 1.00 47.41 O
ATOM 1224 N ALA 292 28.712 9.946 83.046 1.00 48.25 N
ATOM 1225 CA ALA 292 27.381 10.387 83.429 1.00 49.98 C
ATOM 1226 CB ALA 292 27.413 11.017 84.826 1.00 49.98 C
ATOM 1227 C ALA 292 26.883 11.393 82.407 1.00 51.30 C
ATOM 1228 O ALA 292 26.425 12.494 82.811 1.00 50.97 O
ATOM 1229 OXT ALA 292 26.958 11.040 81.206 1.00 51.72 O
ATOM 1230 C GLY 312 22.747 13.032 87.726 1.00 62.83 C
ATOM 1231 O GLY 312 22.832 12.480 86.612 1.00 63.23 O
ATOM 1232 N GLY 312 22.715 15.583 87.887 1.00 62.08 N
ATOM 1233 CA GLY 312 23.516 14.321 88.008 1.00 62.96 C
ATOM 1234 N THR 313 22.004 12.558 88.732 1.00 61.49 N
ATOM 1235 CA THR 313 21.209 11.322 88.647 1.00 60.43 C
ATOM 1236 CB THR 313 22.104 10.096 88.400 1.00 60.61 C
ATOM 1237 OGl THR 313 21.302 8.904 88.437 1.00 61.12 O
ATOM 1238 CG2 THR 313 23.200 10.010 89.480 1.00 60.43 C
ATOM 1239 C THR 313 20.492 11.120 89.983 1.00 59.61 C
ATOM 1240 O THR 313 21.103 10.711 90.974 1.00 59.28 O
ATOM 1241 N PRO 314 19.177 11.385 90.016 1.00 58.60 N
ATOM 1242 CD PRO 314 18.385 11.773 88.830 1.00 58.76 C
ATOM 1243 CA PRO 314 18.315 11.268 91.197 1.00 56.93 C
ATOM 1244 CB PRO 314 17.043 11.987 90.753 1.00 57.28 C
ATOM 1245 CG PRO 314 16.947 11.594 89.316 1.00 58.04 C
ATOM 1246 C PRO 314 18.021 9.875 91.768 1.00 55.04 C
ATOM 1247 O PRO 314 18.190 9.650 92.972 1.00 54.48 O
ATOM 1248 N GLU 315 17.563 8.947 90.932 1.00 52.61 N
ATOM 1249 CA GLU 315 17.237 7.608 91.427 1.00 50.75 C
ATOM 1250 CB GLU 315 16.828 6.686 90.278 1.00 51.66 C
ATOM 1251 CG GLU 315 15.717 7.230 89.389 1.00 53.48 C
ATOM 1252 CD GLU 315 16.247 8.063 88.234 1.00 53.96 C
ATOM 1253 OEl GLU 315 16.739 9.180 88.482 1.00 54.47 O
ATOM 1254 OE2 GLU 315 16.179 7.592 87.075 1.00 54.33 O
ATOM 1255 C GLU 315 18.397 6.977 92.193 1.00 48.44 C
ATOM 1256 O GLU 315 18.203 6.057 92.994 1.00 47.83 O
ATOM 1257 N TYR 316 19.600 7.489 91.966 1.00 46.40 N
ATOM 1258 CA TYR 316 20.779 6.958 92.630 1.00 45.62 C
ATOM 1259 CB TYR 316 21.973 7.025 91.676 1.00 46,77 C
ATOM 1260 CG TYR 316 21.845 6.089 90.496 1.00 49.56 C
ATOM 1261 CDl TYR 316 20.908 6.326 89.492 1.00 51.05 C
ATOM 1262 CEl TYR 316 20.753 5.447 88.431 1.00 51.92 C
ATOM 1263 CD2 TYR 316 22.630 4.945 90.402 1.00 50.92 C
ATOM 1264 CE2 TYR 316 22.480 4.055 89.337 1.00 51.26 C
ATOM 1265 CZ TYR 316 21.543 4.313 88.361 1.00 52.18 C
ATOM 1266 OH TYR 316 21.386 3.436 87.303 1.00 54.26 O
ATOM 1267 C TYR 316 21.151 7.605 93.972 1.00 43.85 C
ATOM 1268 O TYR 316 21.959 7.054 94.718 1.00 43.68 O
ATOM 1269 N LEU 317 20.556 8.755 94.284 1.00 41.16 N
ATOM 1270 CA LEU 317 20.859 9.476 95.526 1.00 38.23 C
ATOM 1271 CB LEU 317 20.053 10.778 95.581 1.00 37.92 C
ATOM 1272 CG LEU 317 20.258 11.743 94.410 1.00 37.87 C
ATOM 1273 CDl LEU 317 19.961 13.165 94.875 1.00 38.13 C
ATOM 1274 CD2 LEU 317 21.692 11.655 93.900 1.00 37.75 C
ATOM 1275 C LEU 317 20.639 8.688 96.819 1.00 36.42 C
ATOM 1276 O LEU 317 19.550 8.164 97.058 1.00 36.55 O
ATOM 1277 N ALA 318 21.679 8.624 97.653 1.00 33.86 N
ATOM 1278 CA ALA 318 21.622 7.907 98.927 1.00 32.05 C
ATOM 1279 CB ALA 318 23.038 7.533 99.389 1.00 33.48 C
ATOM 1280 C ALA 318 20.936 8.753 99.992 1.00 29.98 C
ATOM 1281 O ALA 318 21.082 9.968 100.028 1.00 28.05 O
ATOM 1282 N PRO 319 20.184 8.104 100.888 1.00 30.37 N
ATOM 1283 CD PRO 319 20.057 6.640 100.974 1.00 29.23 C
ATOM 1284 CA PRO 319 19.446 8.748 101.979 1.00 30.55 C
ATOM 1285 CB PRO 319 19.136 7.584 102.903 1.00 29.42 C
ATOM 1286 CG PRO 319 18.906 6.477 101.922 1.00 28.72 C
ATOM 1287 C PRO 319 20.181 9.875 102.690 1.00 30.88 C
ATOM 1288 0 PRO 319 19.635 10.969 102.822 1.00 28.75 O
ATOM 1289 N GLU 320 21.414 9.617 103.141 1.00 30.97 N
ATOM 1290 CA GLU 320 22.187 10.634 103.853 1.00 31.63 C
ATOM 1291 CB GLU 320 23.448 10.038 104.475 1.00 30.90 C
ATOM 1292 CG GLU 320 24.427 9.468 103.473 1.00 31.25 C
ATOM 1293 CD GLU 320 24.104 8.043 103.080 1.00 30.50 C
ATOM 1294 OEl GLU 320 22.904 7.726 102.905 1.00 29.99 O ATOM 1295 OE2 GLU 320 25.056 7.248 102.933 00 29.34 O
ATOM 1296 C GLU 320 22.571 11.804 102.957 00 32.97 C
ATOM 1297 O GLU 320 22.945 12.874 103.439 00 32.23 O
ATOM 1298 N VAL 321 22.492 11.601 101.652 00 33.80 N
ATOM 1299 CA VAL 321 22.806 12.679 100.731 00 35.36 C
ATOM 1300 CB VAL 321 23.137 12.164 99.327 00 35.07 C
ATOM 1301 CGl VAL 321 23.494 13.332 98.429 00 34.41 C
ATOM 1302 CG2 VAL 321 24.284 11.187 99.393 00 36.09 C
ATOM 1303 C VAL 321 21.587 13.580 100.626 00 36.49 C
ATOM 1304 O VAL 321 21.685 14.783 100.834 00 35.87 O
ATOM 1305 N LEU 322 20.439 12.978 100.314 00 38.23 N
ATOM 1306 CA LEU 322 19.190 13.718 100.173 00 40.88 C
ATOM 1307 CB LEU 322 18.014 12.759 99.996 00 39.62 C
ATOM 1308 CG LEU 322 18.056 11.949 98.701 00 40.42 C
ATOM 1309 CDl LEU 322 16.697 11.318 98.427 00 38.95 C
ATOM 1310 CD2 LEU 322 18.449 12.874 97.559 00 40.03 C
ATOM 1311 C LEU 322 18.929 14.626 101.366 00 43.55 C
ATOM 1312 O LEU 322 18.338 15.706 101.228 00 43.01 O
ATOM 1313 N GLU 323 19.366 14.182 102.538 00 45.29 N
ATOM 1314 CA GLU 323 19.185 14.974 103.731 1.00 48.66 C
ATOM 1315 CB GLU 323 19.331 14.092 104.968 00 49.26 C
ATOM 1316 CG GLU 323 18.190 13.120 105.152 00 49.95 C
ATOM 1317 CD GLU 323 18.384 12.218 106.357 00 52.06 C
ATOM 1318 OEl GLU 323 17.441 11.469 106.697 00 52.66 O
ATOM 1319 OE2 GLU 323 19.484 12.249 106.961 00 53.80 O
ATOM 1320 C GLU 323 20.254 16.052 103.704 00 50.31 C
ATOM 1321 O GLU 323 20.834 16.325 102.650 00 50.55 O
ATOM 1322 N ASP 324 20.503 16.683 104.845 00 52.34 N
ATOM 1323 CA ASP 324 21.534 17.711 104.905 00 55.25 C
ATOM 1324 CB ASP 324 21.130 18.863 105.847 00 56.20 C
ATOM 1325 CG ASP 324 20.291 19.942 105.154 00 57.89 C
ATOM 1326 ODl ASP 324 20.068 21.009 105.786 00 58.45 O
ATOM 1327 OD2 ASP 324 19.856 19.734 103.989 00 57.87 O
ATOM 1328 C ASP 324 22.790 17.038 105.448 00 56.40 C
ATOM 1329 O ASP 324 23.917 17.427 105.114 00 57.98 O
ATOM 1330 N ASN 325 22.586 16.023 106.282 00 56.49 N
ATOM 1331 CA ASN 325 23.692 15.302 106.909 00 57.40 C
ATOM 1332 CB ASN 325 23.237 13.908 107.362 00 56.81 C
ATOM 1333 CG ASN 325 23.181 13.786 108.879 00 57.47 C
ATOM 1334 ODl ASN 325 24.210 13.884 109.557 00 55.88 O
ATOM 1335 ND2 ASN 325 21.973 13.582 109.423 1.00 57.68 N
ATOM 1336 C ASN 325 24.952 15.181 106.062 1.00 57.27 C
ATOM 1337 O ASN 325 24.943 15.474 104.867 1.00 58.29 O
ATOM 1338 N ASP 326 26.044 14.764 106.698 1.00 57.28 N
ATOM 1339 CA ASP 326 27.317 14.591 105.999 1.00 57.35 C
ATOM 1340 CB ASP 326 28.423 14.173 106.999 1.00 59.30 C
ATOM 1341 CG- ASP 326 29.003 15.373 107.791 00 62.07 C
ATOM 1342 ODl ASP 326 28.248 16.359 108.043 00 62.18 O
ATOM 1343 OD2 ASP 326 30.213 15.325 108.169 00 61.99 O
ATOM 1344 C ASP 326 27.134 13.528 104.908 00 55.92 C
ATOM 1345 O ASP 326 26.255 13.667 104.037 00 55.85 O
ATOM 1346 N TYR 327 27.962 12.484 104.963 00 53.16 N
ATOM 1347 CA TYR 327 27.931 11.370 104.009 00 50.67 C
ATOM 1348 CB TYR 327 27.095 11.720 102.764 00 51.21 C
ATOM 1349 CG TYR 327 27.850 12.369 101.624 00 53.08 C
ATOM 1350 CDl TYR 327 28.918 11.716 101.005 00 55.54 C
ATOM 1351 CEl TYR 327 29.607 12.289 99.947 00 56.00 C
ATOM 1352 CD2 TYR 327 27.488 13.619 101.147 00 55.22 C
ATOM 1353 CE2 TYR 327 28.167 14.208 100.082 00 56.66 C
ATOM 1354 CZ TYR 327 29.232 13.533 99.485 00 57.89 C
ATOM 1355 OH TYR 327 29.921 14.104 98.421 00 59.39 O
ATOM 1356 C TYR 327 29.356 11.025 103.592 00 47.58 C
ATOM 1357 O TYR 327 30.094 11.899 103.141 00 49.09 O
ATOM 1358 N GLY 328 29.741 9.760 103.750 00 43.26 N
ATOM 1359 CA GLY 328 31.083 9.336 103.377 00 37.58 C
ATOM 1360 C GLY 328 31.117 8.066 102.534 00 34.07 C
ATOM 1361 O GLY 328 30.167 7.779 101.800 00 32.95 O
ATOM 1362 N ARG 329 32.205 7.302 102.659 00 30.38 N
ATOM 1363 CA ARG 329 32.398 6.061 101.907 00 27.34 C
ATOM 1364 CB ARG 329 33.561 5.250 102.496 00 27.99 C
ATOM 1365 CG ARG 329 33.347 4.784 103.925 00 25.86 C
ATOM 1366 CD ARG 329 34.575 4.071 104.472 00 27.88 C
ATOM 1367 NE ARG 329 34.479 3.894 105.916 1.00 28.26 N ATOM 1368 CZ ARG 329 33.575 3.130 106.528 1.00 31.37 C
ATOM 1369 NHl ARG 329 32.679 2.441 105.831 1.00 31.87 N
ATOM 1370 NH2 ARG 329 33.530 3.090 107.850 1.00 31.44 N
ATOM 1371 C ARG 329 31.159 5.183 101.841 1.00 25.98 C
ATOM 1372 O ARG 329 30.998 4.411 100.903 1.00 25.82 O
ATOM 1373 N ALA 330 30.287 5.303 102.837 1.00 24.87 N
ATOM 1374 CA ALA 330 29.066 4.514 102.884 1.00 22.91 C
ATOM 1375 CB ALA 330 28.321 4.777 104.172 1.00 22.20 C
ATOM 1376 C ALA 330 28.150 4.760 101.690 1.00 23.25 C
ATOM 1377 O ALA 330 27.314 3.914 101.385 .00 23.82 O
ATOM 1378 N VAL 331 28.290 5.901 101.016 .00 21.94 N
ATOM 1379 CA VAL 331 27.456 6.167 99.844 00 21.56 C
ATOM 1380 CB VAL 331 27.609 7.620 99.317 ,00 21.31 C
ATOM 1381 CGl VAL 331 27.074 8.614 100.338 .00 24.19 C
ATOM 1382 CG2 VAL 331 29.058 7.905 98.989 ,00 20.81 C
ATOM 1383 C VAL 331 27.837 5.196 98.718 ,00 22.12 C
ATOM 1384 O VAL 331 27.015 4.854 97.873 ,00 21.44 O
ATOM 1385 N ASP 332 29.089 4.752 98.700 ,00 21.45 N
ATOM 1386 CA ASP 332 29.502 3.808 97.675 ,00 21.83 C
ATOM 1387 CB ASP 332 31.016 3.590 97.712 .00 21.08 C
ATOM 1388 CG ASP 332 31.795 4.841 97.322 ,00 21.05 C
ATOM 1389 ODl ASP 332 31.300 5.607 96.461 .00 21.53 O
ATOM 1390 OD2 ASP 332 32.901 5.048 97.867 1.00 18.74 O
ATOM 1391 C ASP 332 28.780 2.472 97.852 1.00 22.23 C
ATOM 1392 O ASP 332 28.428 1.820 96.875 1 ,00 22.57 O
ATOM 1393 N TRP 333 28.557 2.069 99.098 1.00 20.70 N
ATOM 1394 CA TRP 333 27.873 0.811 99.357 1.00 22.31 C
ATOM 1395 CB TRP 333 28.043 0.403 100.818 1.00 20.84 C
ATOM 1396 CG TRP 333 29.476 0.232 101.192 1.00 21.71 C
ATOM 1397 CD2 TRP -333 30.468 -0.514 100.479 1 ,00 21.93 C
ATOM 1398 CE2 TRP 333 31.680 -0.372 101.182 1.00 21.89 C
ATOM 1399 CE3 TRP 333 30.449 -1.291 99.314 1.00 23.41 C
ATOM 1400 CDl TRP 333 30.105 0.777 102.265 1.00 22.62 C
ATOM 1401 KtEl TRP 333 31.428 0.420 102.268 .00 24.32 N
ATOM 1402 CZ2 TRP 333 32.867 -0.972 100.763 .00 24.06 C
ATOM 1403 CZ3 TRP 333 31.626 -1.889 98.897 .00 23.14 C
ATOM 1404 CH2 TRP 333 32.822 -1.725 99.621 .00 24.63 C
ATOM 1405 C TRP 333 26.399 0.924 99.003 .00 22.26 C
ATOM 1406 O TRP 333 25.747 -0.077 98.726 .00 24.29 O
ATOM 1407 N TRP 334 25.872 2.142 99.022 .00 22.85 N
ATOM 1408 CA TRP 334 24.474 2.358 98.650 .00 23.49 C
ATOM 1409 CB TRP 334 23.988 3.729 99.132 .00 23.13 C
ATOM 1410 CG TRP 334 22.661 4.127 98.558 ,00 21.78 C
ATOM 1411 CD2 TRP 334 21.376 3.935 99.157 1.00 20.40 C
ATOM 1412 CE2 TRP 334 20.412 4.392 98.234 21.57 C
ATOM 1413 CE3 TRP 334 20.944 3.416 100.382 20.84 C
ATOM 1414 CDl TRP 334 22.431 4.684 97.330 22.08 C
ATOM 1415 NEl TRP 334 21.084 4.844 97.129 21.47 N
ATOM 1416 CZ2 TRP 334 19.046 4.345 98.496 19.48 C
ATOM 1417 CZ3 TRP 334 19.588 3.372 100.640 22.06 C
ATOM 1418 CH2 TRP 334 18.654 3.834 99.700 20.08 C
ATOM 1419 C TRP 334 24.406 2.274 97.123 22.78 C
ATOM 1420 O TRP 334 23.441 1.766 96.552 21.53 O
ATOM 1421 N GLY 335 25.456 2.774 96.475 21.88 N
ATOM 1422 CA GLY 335 25.527 2.729 95.027 20.72 C
ATOM 1423 C GLY 335 25.601 1.288 94.566 20.57 C
ATOM 1424 O GLY 335 24.921 0.893 93.622 22.76 O
ATOM 1425 N LEU 336 26.426 0.493 95.238 18.84 N
ATOM 1426 CA LEU 336 26.561 -0.913 94.894 18.83 C
ATOM 1427 CB LEU 336 27.547 -1.610 95.829 15.00 C
ATOM 1428 CG LEU 336 27.660 -3.124 95.612 16.79 C
ATOM 1429 CDl LEU 336 28.297 .408 94.247 16.71 C
ATOM 1430 CD2 LEU 336 28.491 .741 96.730 13.09 C
ATOM 1431 C LEU 336 25.205 .608 94.993 19.91 C
ATOM 1432 O LEU 336 24.834 .390 94.118 21.19 O
ATOM 1433 N GLY 337 24.472 .311 96.062 19.56 N
ATOM 1434 CA GLY 337 23.174 1.921 96.262 19.79 C
ATOM 1435 C GLY 337 22.235 -1 585 95.127 20.28 C
ATOM 1436 O GLY 337 21.498 2.433 94.640 19.83 O
ATOM 1437 N VAL 338 22.275 0.336 94.688 20.99 N
ATOM 1438 CA VAL 338 21.412 0.078 93.606 21.38 C
ATOM 1439 CB VAL 338 21.533 1.575 93.356 22.46 C
ATOM 1440 CGl VAL 338 20.757 1.952 92.106 1.00 23.07 C ATOM 1441 CG2 VAL 338 21.008 2.329 94.561 1.00 24.62 C
ATOM 1442 C VAL 338 21.675 -0.673 92.307 1.00 21.46 C
ATOM 1443 O VAL 338 20.746 -1.235 91.736 1.00 23.36 O
ATOM 1444 N VAL 339 22.925 -0.691 91.839 1.00 19.80 N
ATOM 1445 CA VAL 339 23.249 -1.396 90.596 1.00 18.55 C
ATOM 1446 CB VAL 339 24.710 -1.138 90.136 1.00 19.02 C
ATOM 1447 CGl VAL 339 24.984 0.346 90.070 1.00 20.65 C
ATOM 1448 CG2 VAL 339 25.676 -1.809 91.057 1.00 19.99 C
ATOM 1449 C VAL 339 23.026 -2.915 90.672 1.00 18.52 C
ATOM 1450 O VAL 339 22.502 -3.514 89.732 1.00 19.11 O
ATOM 1451 N MET 340 23.417 -3.543 91.776 1.00 18.47 N
ATOM 1452 CA MET 340 23.217 -4.983 91.903 1.00 18.51 C
ATOM 1453 CB MET 340 23.886 -5.524 93.168 1.00 18.30 C
ATOM 1454 CG MET 340 25.400 -5.658 93.038 1.00 17.27 C
ATOM 1455 SD MET 340 26.178 -6.430 94.461 1.00 17.92 S
ATOM 1456 CE MET 340 25.933 -8.166 94.095 1.00 16.83 C
ATOM 1457 C MET 340 21.735 -5.341 91.905 1.00 19.54 C
ATOM 1458 O MET 340 21.349 -6.407 91.430 1.00 17.82 O
ATOM 1459 N TYR 341 20.915 -4.441 92.438 1.00 20.50 N
ATOM 1460 CA TYR 341 19.477 -4.660 92.476 1.00 23.05 C
ATOM 1461 CB TYR 341 18.795 -3.565 93.315 1.00 23.63 C
ATOM 1462 CG TYR 341 17.274 -3.667 93.371 1.00 24.94 C
ATOM 1463 CDl TYR 341 16.489 -3.242 92.305 1.00 24.07 C
ATOM 1464 CEl TYR 341 15.112 -3.360 92.337 1.00 24.96 C
ATOM 1465 CD2 TYR 341 16.630 -4.216 94.479 1.00 25.60 C
ATOM 1466 CE2 TYR 341 15.247 -4.341 94.520 1.00 24.05 C
ATOM 1467 CZ TYR 341 14.499 -3.910 93.443 1.00 24.88 C
ATOM 1468 OH TYR 341 13.141 -4.027 93.463 1.00 22.72 O
ATOM 1469 C TYR 341 18.950 -4.654 91.038 1.00 24.32 C
ATOM 1470 O TYR 341 18.177 -5.525 90.647 1.00 26.09 O
ATOM 1471 N GLU 342 19.397 -3.678 90.253 1.00 24.73 N
ATOM 1472 CA GLU 342 18.992 -3.553 88.857 1.00 25.14 C
ATOM 1473 CB GLU 342 19.618 -2.307 88.241 1.0O 26.93 C
ATOM 1474 CG GLU 342 18.895 -1.015 88.525 1.00 30.49 C
ATOM 1475 CD GLU 342 19.550 0.160 87.817 1.00 34.03 C
ATOM 1476 OEl GLU 342 20.608 0.622 88.297 1.00 32.20 O
ATOM 1477 OE2 GLU 342 19.018 0.606 86.769 1.00 36.46 O
ATOM 1478 C GLU 342 19.393 -4.757 88.014 1.00 24.53 C
ATOM 1479 O GLU 342 18.642 -5.195 87.138 1.00 25.38 O
ATOM 1480 N MET 343 20.588 -5.276 88.265 1.00 23.61 N
ATOM 1481 CA MET 343 21.084 -6.419 87.514 1.00 24.27 C
ATOM 1482 CB MET 343 22.571 -6.658 87.825 1.00 22.77 C
ATOM 1483 CG MET 343 23.510 -5.602 87.247 1.00 24.11 C
ATOM 1484 SD MET 343 25.275 -5.849 87.638 1.00 23.34 S
ATOM 1485 CE MET 343 25.562 -4.447 88.718 1.00 24.71 C
ATOM 1486 C MET 343 20.275 -7.676 87.807 1.00 24.41 C
ATOM 1487 O MET 343 19.914 -8.411 86.894 1.00 25.88 O
ATOM 1488 N MET 344 19.980 -7.911 89.080 1.00 26.28 N
ATOM 1489 CA MET 344 19.224 -9.091 89.477 1.00 28.46 C
ATOM 1490 CB MET 344 19.527 -9.462 90.924 1.00 28.43 C
ATOM 1491 CG MET 344 20.863 -10.160 91.134 1.00 30.52 C
ATOM 1492 SD MET 344 21.054 -10.676 92.854 1.00 30.90 S
ATOM 1493 CE MET 344 21.808 -9.255 93.538 1.00 30.62 I c
ATOM 1494 C MET 344 17.721 -8.950 89.335 1.00 30.14 C
ATOM 1495 O MET 344 17.028 -9.936 89.100 1.00 31.94 O
ATOM 1496 N CYS 345 17.221 -7.729 89.476 1.00 30.80 N
ATOM 1497 CA CYS 345 15.789 -7.483 89.409 1.00 30.91 C
ATOM 1498 CB CYS 345 15.385 -6.561 90.566 1.00 29.48 C
ATOM 1499 SG CYS 345 15.780 -7.263 92.212 1.00 30.60 S
ATOM 1500 C CYS 345 15.330 -6.908 88.076 1.00 31.92 C
ATOM 1501 O CYS 345 14.155 -6.976 87.734 1.00 31.72 O
ATOM 1502 N GLY 346 16.260 -6.341 87.321 1.00 33.13 N
ATOM 1503 CA GLY 346 15.902 -5.784 86.033 1.00 34.12 C
ATOM 1504 C GLY 346 15.153 -4.466 86.088 1.00 34.81 C
ATOM 1505 O GLY 346 14.533 -4.067 85.101 1.00 34.95 O
ATOM 1506 N ARG 347 15.182 -3.789 87.229 1.00 34.88 N
ATOM 1507 CA ARG 347 14.503 -2.495 87.333 1.00 36.21 C
ATOM 1508 CB ARG 347 12.991 -2.676 87.555 1.00 38.73 C
ATOM 1509 CG ARG 347 12.600 -2.948 89.005 1.00 41.75 C
ATOM 1510 CD ARG 347 11.084 -2.937 89.209 1.00 45.08 C
ATOM 1511 NE ARG 347 10.425 -4.034 88.505 1.00 50.00 N
ATOM 1512 CZ ARG 347 9.121 -4.313 88.590 1.00 52.16 C
ATOM 1513 NHl ARG 347 8.320 -3.565 89.350 1.00 52.86 N ATOM 1514 NH2 ARG 347 8.618 -5.357 87.931 1.00 51.98 N
ATOM 1515 C ARG 347 15.090 -1.686 88.480 1.00 35.19 C
ATOM 1516 O ARG 347 15.814 -2.233 89.323 1.00 33.39 O
ATOM 1517 N LEU 348 14.800 -0.386 88.504 1.00 34.11 N
ATOM 1518 CA LEU 348 15.301 0.4S6 89.577 1.00 34.99 C
ATOM 1519 CB LEU 348 15.038 1.950 89.290 1.00 36.79 C
ATOM 1520 CG LEU 348 16.084 2.720 88.466 1.00 38.35 C
ATOM 1521 CDl LEU 348 15.777 4.205 88.503 1.00 38.99 C
ATOM 1522 CD2 LEU 348 17.483 2.486 89.039 1.00 39.82 C
ATOM 1523 C LEU 348 14.639 0.085 90.894 1.00 35.06 C
ATOM 1524 O LEU 348 13.481 -0.345 90.929 1.00 35.14 O
ATOM 1525 N PRO 349 15.376 0.215 91.999 1.00 35.50 N
ATOM 1526 CD PRO 349 16.793 0.607 92.120 1.00 35.23 C
ATOM 1527 CA PRO 349 14.809 -0.128 93.304 1.00 36.61 C
ATOM 1528 CB PRO 349 16.031 -0.125 94.221 1.00 35.98 C
ATOM 1529 CG PRO 349 16.913 0.928 93.590 1.00 34.22 C
ATOM 1530 C PRO 349 13.782 0.910 93.719 1.00 37.47 C
ATOM 1531 O PRO 349 12.815 0.591 94.405 1.00 37.21 O
ATOM 1532 N PHE 350 14.009 2.150 93.283 1.00 39.51 N
ATOM 1533 CA PHE 350 13.139 3.279 93.598 1.00 41.83 C
ATOM 1534 CB PHE 350 13.779 4.143 94.688 1.00 40.23 C
ATOM 1535 CG PHE 350 14.000 - 3.418 95.988 1.00 39.20 C
ATOM 1536 CDl PHE 350 12.932 2.865 96.681 1.00 37.90 C
ATOM 1537 CD2 PHE 350 15.278 3.281 96.514 1.00 37.97 C
ATOM 1538 CEl PHE 350 13.134 2.189 97.868 1.00 37.23 C
ATOM 1539 CE2 PHE 350 15.483 2.604 97.705 1.00 37.53 C
ATOM 1540 CZ PHE 350 14.413 2.059 98.379 1.00 38.13 C
ATOM 1541 C PHE 350 12.868 4.155 92.379 1.00 44.35 C
ATOM 1542 O PHE 350 13.801 4.519 91.645 1.00 43.92 O
ATOM 1543 N TYR 351 11.594 4.500 92.172 1.00 47.32 N
ATOM 1544 CA TYR 351 11.215 5.359 91.049 1.00 50.40 C
ATOM 1545 CB TYR ■351 ■ 11.250 4.578 89.733 1.00 51.97 C
ATOM 1546 CG TYR 351 11.160 5.487 88.521 1.00 53.89 C
ATOM 1547 CDl TYR 351 12.208 6.346 88.195 1.00 55.06 C
ATOM 1548 CEl TYR 351 12.106 7.230 87.118 1.00 54.64 C
ATOM 1549 CD2 TYR 351 10.005 5.531 87.735 1.00 54.09 C
ATOM 1550 CE2 TYR 351 9.898 6.414 86.658 1.00 53.78 C
ATOM 1551 CZ TYR 351 10.948 7.256 86.361 1.00 53.43 C
ATOM 1552 OH TYR 351 10.840 8.142 85.313 1.00 54.28 O
ATOM 1553 C TYR 351 9.860 6.077 91.145 1.00 51.36 C
ATOM 1554 O TYR 351 8.981 5.711 91.930 1.00 51.48 O
ATOM 1555 N ASN 352 9.722 7.112 90.319 1.00 52.70 N
ATOM 1556 CA ASN 352 8.518 7.925 90.227 1.00 52.77 C
ATOM 1557 CB ASN 352 8.043 8.381 91.607 1.00 53.27 C
ATOM 1558 CG ASN 352 6.733 9.164 91.529 1.00 54.15 C
ATOM 1559 ODl ASN 352 6.374 9.683 90.465 1.00 52.43 O
ATOM 1560 ND2 ASN 352 6.020 9.258 92.653 1.00 55.00 N
ATOM 1561 C ASN 352 8.776 9.158 89.360 1.0O 52.88 C
ATOM 1562 O ASN 352 9.841 9.776 89.433 1.00 51.11 O
ATOM 1563 N GLN 353 7.783 9.507 88.547 1.00 54.82 N
ATOM 1564 CA GLN 353 7.860 10.558 87.640 1.00 56.56 C
ATOM 1565 CB GLN 353 6.588 10.729 86.781 1.00 57.53 C
ATOM 1566 CG GLN 353 6.333 9.480 85.928 1.00 59.01 C
ATOM 1567 CD GLN 353 4.903 9.419 85.385 1.00 60.41 C
ATOM 1568 OEl GLN 353 4.472 10.300 84.631 1.00 59.97 O
ATOM 1569 NE2 GLN 353 4.159 8.372 85.773 1.00 60.45 N
ATOM 1570 C GLN 353 8.033 11.973 88.401 1.00 56.31 C
ATOM 1571 O GLN 353 8.516 12.969 87.843 1.00 56.10 O
ATOM 1572 N ASP 354 7.617 11.978 89.666 1.00 56.27 N
ATOM 1573 CA ASP 354 7.740 13.164 90.514 1.00 56.30 C
ATOM 1574 CB ASP 354 6.553 13.261 91.476 1.00 56.06 C
ATOM 1575 CG ASP 354 6.556 14.551 92.292 1.00 56.56 C
ATOM 1576 ODl ASP 354 5.655 14.702 93.147 1.00 57.98 O
ATOM 1577 OD2 ASP 354 7.444 15.417 92.083 1.00 55.51 O
ATOM 1578 C ASP 354 9.047 13.007 91.287 1.00 55.97 C
ATOM 1579 O ASP 354 9.115 12.355 92.333 1.00 55.29 O
ATOM 1580 N HIS 355 10.099 13.600 90.752 1.00 56.74 N
ATOM 1581 CA HIS 355 11.393 13.492 91.387 1.00 57.99 C
ATOM 1582 CB HIS 355 12.424 14.256 90.552 1.00 59.57 C
ATOM 1583 CG HIS 355 12.688 13.612 89.220 1.00 61.21 C
ATOM 1584 CD2 HIS 355 12.441 12.354 88.777 1.00 61.42 C
ATOM 1585 NDl HIS 355 13.273 14.280 88.164 1.00 61.70 N
ATOM 1586 CEl HIS 355 13.375 13.461 87.128 1.00 62.07 C ATOM 1587 NE2 HIS 355 12.878 12.286 87.474 1.00 61.86 N
ATOM 1588 C HIS 355 11.375 13.931 92.852 1.00 57.64 C
ATOM 1589 O HIS 355 12.409 13.870 93.530 1.00 58.54 O
ATOM 1590 N GLU 356 10.205 14.355 93.344 1.00 55.37 N
ATOM 1591 CA GLU 356 10.066 14.745 94.751 1.00 52.91 C
ATOM 1592 CB GLU 356 9.288 16.059 94.912 1.00 53.66 C
ATOM 1593 CG GLU 356 9.122 16.454 96.381 1.00 54.19 C
ATOM 1594 CD GLU 356 8.859 17.942 96.593 1-00 54.27 C
ATOM 1595 OEl GLU 356 7.673 18.336 96.751 1.00 53.45 O
ATOM 1596 OE2 GLU 356 9.846 18.712 96.599 1.00 52.92 O
ATOM 1597 C GLU 356 9.338 13.630 95.501 1.00 50.63 C
ATOM 1598 O GLU 356 9.414 13.519 96.725 1.00 49.18 O
ATOM 1599 N LYS 357 8.612 12.807 94.761 1.00 49.07 N
ATOM 1600 CA LYS 357 7.923 11.695 95.387 1.00 47.47 C
ATOM 1601 CB LYS 357 6.790 11.183 94.498 1.00 47.47 C
ATOM 1602 CG LYS 357 5.391 11.338 95.111 1.00 48.74 C
ATOM 1603 CD LYS 357 4.766 12.698 94.801 1.00 48.98 C
ATOM 1604 CE LYS 357 3.567 12.572 93.839 1.00 50.15 C
ATOM 1605 NZ LYS 357 3.930 12.063 92.474 1.00 48.67 N
ATOM 1606 C LYS 357 9.008 10.640 95.511 1.00 45.87 C
ATOM 1607 O LYS 357 9.081 9.905 96.495 1.00 45.66 O
ATOM 1608 N LEU 358 9.867 10.601 94.500 1.00 44.71 N
ATOM 1609 CA LEU 358 10.975 9.657 94.439 1.00 44.19 C
ATOM 1610 CB LEU 358 11.786 9.932 93.173 1.00 43.83 C
ATOM 1611 CG LEU 358 13.083 9.191 92.853 1.00 44.00 C
ATOM 1612 CDl LEU 358 12.941 7.697 93.043 1.00 42.41 C
ATOM 1613 CD2 LEU 358 13.449 9.518 91.408 1.00 44.03 C
ATOM 1614 C LEU 358 11.857 9.779 95.678 1.00 44.67 C
ATOM 1615 O LEU 358 12.469 8.804 96.119 1.00 42.76 O
ATOM 1616 K PHE 359 11.913 10.979 96.247 1.00 45.00 N
ATOM 1617 CA PHE 359 12.727 11.201 97.434 1.00 46.47 C
ATOM 1618 CB PHE 359 12.936 12.702 97.664 1.00 47.31 C
ATOM 1619 CG PHE 359 13.662 13.384 96.540 1.00 48.24 C
ATOM 1620 CDl PHE 359 14.592 12.685 95.777 1.00 48.67 C
ATOM 1621 CD2 PHE 359 13.443 14.726 96.262 1.00 48.83 C
ATOM 1622 CEl PHE 359 15.290 13.310 94.758 1.00 47.47 C
ATOM 1623 CE2 PHE 359 14.139 15.356 95.244 1.00 48.84 C
ATOM 1624 CZ PHE 359 15.065 14.645 94.493 1.00 48.15 C
ATOM 1625 C PHE 359 12.082 10.582 98.662 1.00 46.03 C
ATOM 1626 O PHE 359 12.772 10.039 99.533 1.00 45.79 O
ATOM 1627 N GLU 360 10.755 10.679 98.719 1.00 46.05 N
ATOM 1628 CA GLU 360 9.955 10.139 99.819 1.00 45.50 C
ATOM 1629 CB GLU 360 8.454 10.294 99.519 1.00 46.56 C
ATOM 1630 CG GLU 360 7.929 11.716 99.563 1.00 48.78 C
ATOM 1631 CD GLU 360 7,604 12.172 100.974 1.00 49.33 C
ATOM 1632 OEl GLU 360 7.243 13.360 101.159 1.00 48.97 O
ATOM 1633 OE2 GLU 360 7.706 11.332 101.898 1.00 50.81 O
ATOM 1634 C GLU 360 10.265 8.669 99.972 1.00 44.52 C
ATOM 1635 O GLU 360 10.580 8.204 101.062 1.00 45.34 O
ATOM 1636 N LEU 361 10.154 7.935 98.870 1.00 43.70 N
ATOM 1637 CA LEU 361 10.427 6.505 98.877 1.00 42.78 C
ATOM 1638 CB LEU 361 10.082 5.890 97.514 1.00 44.18 C
ATOM 1639 CG LEU 361 8.634 6.036 97.031 1.00 45.10 C
ATOM 1640 CDl LEU 361 8.330 7.500 96.729 1.00 44.25 C
ATOM 1641 CD2 LEU 361 8.429 5.190 95.780 1.00 44.21 C
ATOM 1642 C LEU 361 11.897 6.232 99.199 1.00 40.62 C
ATOM 1643 O LEU 361 12.217 5.315 99.944 1.00 40.94 O
ATOM 1644 N ILE 362 12.791 7.032 98.640 1.00 38.34 N
ATOM 1645 CA ILE 362 14.206 6.827 98.889 1.00 38.19 C
ATOM 1646 CB ILE 362 15.053 7.785 98.036 1.00 36.27 C
ATOM 1647 CG2 ILE 362 16.464 7.852 98.570 1.00 34.79 C
ATOM 1648 CGl ILE 362 15.007 7.323 96.575 1.00 36.51 C
ATOM 1649 CDl ILE 362 15.841 8.151 95.629 1.00 35.86 C
ATOM 1650 C ILE 362 14.534 6.998 100.369 1.00 38.78 C
ATOM 1651 O ILE 362 15.472 6.386 100.882 1.00 38.45 O
ATOM 1652 N LEU 363 13.745 7.817 101.057 1.00 39.04 N
ATOM 1653 CA LEU 363 13.960 8.037 102.479 1.00 38.88 C
ATOM 1654 CB LEU 363 13.809 9.523 102.823 1.00 39.01 C
ATOM 1655 CG LEU 363 15.101 10.295 103.140 1.00 39.96 C
ATOM 1656 CDl LEU 363 16.180 9.303 103.539 1.00 41.09 C
ATOM 1657 CD2 LEU 363 15.568 11.098 101.941 1.00 39.59 C
ATOM 1658 C LEU 363 13.012 7.233 103.363 1.00 39.38 C
ATOM 1659 O LEU 363 13.286 7.060 104.547 1.00 39.54 O US2004/026569
ATOM 1660 N MET 364 11.922 6.709 102.797 1.00 39.78 N
ATOM 1661 CA MET 364 10.940 5.990 103.613 1.00 40.94 C
ATOM 1662 CB MET 364 9.648 6.809 103.674 1.00 41.27 C
ATOM 1663 CG MET 364 9.839 8.296 103.963 1.00 43.34 C
ATOM 1664 SD MET 364 9.839 8.728 105.713 1.00 42.65 S
ATOM 1665 CE MET 364 11.535 8.396 106.157 1.00 43.08 C
ATOM 1666 C MET 364 10.548 4.548 103.261 1.00 40.60 C
ATOM 1667 O MET 364 10.260 3.754 104.159 1.00 40.50 O
ATOM 1668 N GLU 365 10.507 4.203 101.978 1.00 40.93 N
ATOM 1669 CA GLU 365 10.082 2.853 101.596 1.00 42.58 C
ATOM 1670 CB GLU 365 9.551 2.858 100.167 1.00 44.63 C
ATOM 1671 CG GLU 365 8.285 3.675 100.016 1.00 48.60 C
ATOM 1672 CD GLU 365 7.269 3.386 101.123 1.00 51.71 C
ATOM 1673 OEl GLU 365 6.840 2.204 101.259 1.00 52.77 O
ATOM 1674 OE2 GLU 365 6.907 4.347 101.854 1.00 51.60 O
ATOM 1675 C GLU 365 11.063 1.699 101.745 1.00 41.58 C
ATOM 1676 O GLU 365 12.263 1.839 101.481 1.00 43.41 O
ATOM 1677 N ASP 366 10.548 0.557 102.186 1.00 40.13 N
ATOM 1678 CA ASP 366 11.383 -0.626 102.319 1.00 40.34 C
ATOM 1679 CB ASP 366 10.700 -1.691 103.188 1.00 41.43 C
ATOM 1680 CG ASP 366 10.505 -1.245 104.627 1.00 43.67 C
ATOM 1681 ODl ASP 366 11.492 -0.786 105.246 1.00 46.08 O
ATOM 1682 OD2 ASP 366 9.368 -1.364 105.155 1.00 44.99 O
ATOM 1683 C ASP 366 11.526 -1.158 100.897 1.00 39.23 C
ATOM 1684 O ASP 366 10.574 -1.080 100.121 1.00 38.83 O
ATOM 1685 N ILE 367 12.701 -1.673 100.535 1.00 38.44 N
ATOM 1686 CA ILE 367 12.863 -2.223 99.192 1.00 36.82 C
ATOM 1687 CB ILE 367 14.327 -2.622 98.870 1.00 37.83 C
ATOM 1688 CG2 ILE 367 14.717 -2.074 97.519 1.00 34.60 C
ATOM 1689 CGl ILE 367 15.274 -2.156 99.982 1.00 39.22 C
ATOM 1690 CDl ILE 367 15.201 -3.013 101.231 1.00 39.63 C
ATOM 1691 C ILE 367 12.029 -3.493 99.074 1.00 36.44 C
ATOM 1692 O ILE 367 11.839 -4.213 100.050 1.00 36.01 O
ATOM 1693 N LYS 368 11.531 -3.760 97.873 1.00 36.78 N
ATOM 1694 CA LYS 368 10.741 -4.963 97.610 1.00 38.41 C
ATOM 1695 CB LYS 368 9.335 ^-4.594 97.108 1.00 38.63 C
ATOM 1696 CG LYS 368 8.329 -4.275 98.218 1.00 40.81 C
ATOM 1697 CD LYS 368 8.744 -3.080 99.088 1.00 43.03 C
ATOM 1698 CE LYS 368 7.845 -2.960 100.336 1.00 44.38 C
ATOM 1699 NZ LYS 368 8.055 -1.693 101.114 1.00 44.84 N
ATOM 1700 C LYS 368 11.493 -5.783 96.557 1.00 37.35 C
ATOM 1701 O LYS 368 12.127 -5.226 95.659 1.00 35.62 O
ATOM 1702 N PHE 369 11.411 -7.104 96.662 1.00 37.00 N
ATOM 1703 CA PHE 369 12.137 -7.973 95.742 1.00 36.81 C
ATOM 1704 CB PHE 369 13.221 -8.752 96.493 1.00 35.24 C
ATOM 1705 CG PHE 369 14.154 -7.903 97.316 1.00 34.37 C
ATOM 1706 CDl PHE 369 15.043 -7.031 96.711 1.00 31.60 C
ATOM 1707 CD2 PHE 369 14.192 -8.046 98.696 1.00 33.18 C
ATOM 1708 CEl PHE 369 15.958 -6.323 97.461 1.00 34.18 C
ATOM 1709 CE2 PHE 369 15.105 -7.343 99.458 1.00 34.58 C
ATOM 1710 CZ PHE 369 15.998 -6.476 98.838 1.00 33.69 C
ATOM 1711 C PHE 369 11.249 -9.010 95.084 1.00 36.99 C
ATOM 1712 O PHE 369 10.155 -9.303 95.573 1.00 37.79 O
ATOM 1713 N PRO 370 11.708 -9.576 93.952 1.00 36.43 N
ATOM 1714 CD PRO 370 12.870 -9.179 93.136 1.00 34.43 C
ATOM 1715 CA PRO 370 10.908 -10.608 93.282 1.00 35.35 C
ATOM 1716 CB PRO 370 11.691 -10.875 91.997 1.00 34.92 C
ATOM 1717 CG PRO 370 12.423 -9.563 91.749 1.00 34.17 C
ATOM 1718 C PRO 370 11.021 -11.771 94.285 1.00 35.71 C
ATOM 1719 O PRO 370 12.017 -11.843 95.009 1.00 34.91 O
ATOM 1720 N ARG 371 10.039 -12.673 94.343 1.00 36.26 N
ATOM 1721 CA ARG 371 10.092 -13.773 95.316 1.00 34.84 C
ATOM 1722 CB ARG 371 8.739 -14.480 95.387 1.00 38.44 C
ATOM 1723 CG ARG 371 7.625 -13.585 95.895 1.00 41.13 C
ATOM 1724 CD ARG 371 8.093 -12.805 97.124 1.00 44.42 C
ATOM 1725 NE ARG 371 8.315 -13.654 98.296 1.00 46.7S N
ATOM 1726 CZ ARG 371 7.339 -14.159 99.050 1.00 48.87 C
ATOM 1727 NHl ARG 371 6.065 -13.902 98.762 1.00 48.66 N
ATOM 1728 NH2 ARG 371 7.634 -14.924 100.098 1.00 48.64 N
ATOM 1729 C ARG 371 11.181 -14.812 95.091 1.00 33.12 C
ATOM 1730 O ARG 371 11.762 -15.343 9S.047 1.00 32.60 O
ATOM 1731 N THR 372 11.463 -15.094 93.827 1.00 31.07 N
ATOM 1732 CA THR 372 12.461 -16.090 93.469 1.00 30.05 C ATOM 1733 CB THR 372 12.292 -16.485 91.992 .00 31.21 C
ATOM 1734 OGl THR 372 12.095 -15.300 91.216 .00 34.22 O
ATOM 1735 CG2 THR 372 11.062 -17.392 91.810 .00 31.07 C
ATOM 1736 C THR 372 13.920 -15.686 93.747 .00 29.38 C
ATOM 1737 O THR 372 14.820 -16.532 93.717 .00 27.55 O
ATOM 1738 N LEU 373 14.162 -14.408 94.026 .00 26.30 N
ATOM 1739 CA LEU 373 15.525 -13.983 94.322 .00 25.54 C
ATOM 1740 CB LEU 373 15.592 -12.484 94.616 .00 25.42 C
ATOM 1741 CG LEU 373 16.722 -11.692 93.945 .00 26.66 C
ATOM 1742 CDl LEU 373 16.422 -11.510 92.450 1.00 25.77 Q
ATOM 1743 CD2 LEU 373 16.858 -10.335 94.616 .00 22.56 C
ATOM 1744 C LEU 373 15.922 -14.761 95.564 00 24.99 C
ATOM 1745 O LEU 373 15.162 -14.797 96.531 .00 27.01 O
ATOM 1746 N SER 374 17.100 -15.385 95.528 .00 23.49 N
ATOM 1747 CA SER 374 17.605 -16.176 96.639 .00 22.32 C
ATOM 1748 CB SER 374 19.031 -16.670 96.363 ,00 22.76 C
ATOM 1749 OG SER 374 19.955 -15.604 96.443 ,00 23.63 O
ATOM 1750 C SER 374 17.631 -15.386 97.924 ,00 22.83 C
ATOM 1751 O SER 374 17.765 -14.160 97.921 .00 23.60 O
ATOM 1752 N SER 375 17.525 -16.110 99.026 ,00 22.10 N
ATOM 1753 CA SER 375 17.547 -15.501 100.343 .00 23.12 C
ATOM 1754 CB SER 375 17.473 -16.591 101.412 .00 20.88 C
ATOM 1755 OG SER 375 17.557 -16.020 102.700 ,00 23.81 O
ATOM 1756 C SER 375 18.799 -14.631 100.551 ,00 21.11 C
ATOM 1757 O SER 375 18.687 -13.482 100.940 .00 20.37 O
ATOM 1758 N ASP . 376 19.984 -15.178 100.293 .00 20.80 N
ATOM 1759 CA ASP 376 21.222 -14.412 100.468 .00 20.42 C
ATOM 1760 CB ASP 376 22.451 -15.247 100.087 .00 21.48 C
ATOM 1761 CG ASP 376 22.698 -16.406 101.037 .00 22.91 C
ATOM 1762 ODl ASP 376 22.280 -16.341 102.215 1.00 25.30 O
ATOM 1763 OD2 ASP 376 23.336 -17.380 100.609 23.17 O
ATOM 1764 C ASP 376 21.212 -13.126 99.635 19.93 C
ATOM 17S5 O ASP 376 21.700 -12.093 100.070 18.84 O
ATOM 1766 N ALA 377 20.663 -13.207 98.429 20.30 N
ATOM 1767 CA ALA 377 20.577 -12.041 97.570 21.18 C
ATOM 1768 CB ALA 377 19.934 -12.415 96.233 19.65 C
ATOM 1769 C ALA 377 19.757 -10.961 98.271 21.23 C
ATOM 1770 O ALA 377 20.219 -9.834 98.439 23.31 O
ATOM 1771 N LYS 378 18.541 -11.314 98.681 22.23 N
ATOM 1772 CA LYS 378 17.663 -10.370 99.364 22.66 C
ATOM 1773 CB LYS 378 16.346 -11.041 99.738 24.37 C
ATOM 1774 CG LYS 378 15.402 -11.251 98.569 25.88 C
ATOM 1775 CD LYS 378 14.225 -12.097 99.011 29.18 C
ATOM 1776 CE LYS 378 13.305 -12.490 97.867 29.84 C
ATOM 1777 N2 LYS 378 12.304 -13.494 98.352 27.09 N
ATOM 1778 C LYS 378 18.316 -9.784 100.607 22.31 C
ATOM 1779 O LYS 378 18.085 -8.629 100.956 22.18 O
ATOM 1780 N SER 379 19.130 -10.589 101.278 22.39 N
ATOM 1781 CA SER 379 19.829 -10.126 102.462 21.38 C
ATOM 1782 CB SER 379 20.549 -11.286 103.138 22.82 C
ATOM 1783 OG SER 379 21.239 -10.832 104.280 22.30 O
ATOM 1784 C SER 379 20.839 -9.059 102.044 22.01 C
ATOM 1785 O SER 379 20.843 -7.954 102.582 21.98 O
ATOM 1786 N LEU 380 21.677 -9.397 101.069 20.41 N
ATOM 1787 CA LEU 380 22.687 -8.474 100.570 20.59 C
ATOM 1788 CB LEU 380 23.356 -9.033 99.315 16.49 C
ATOM 1789 CG LEU 380 24.512 -8.172 98.792 17.40 C
ATOM 1790 CDl LEU 380 25.784 -8.464 99.597 13.77 C
ATOM 1791 CD2 LEU 380 24.757 -8.472 97.327 16.29 C
ATOM 1792 C LEU 380 22.083 -7.118 100.224 20.50 C
ATOM 1793 O LEU 380 22.475 -6.083 100.773 21.45 O
ATOM 1794 N LEU 381 21.131 -7.136 99.302 18.97 N
ATOM 1795 CA LEU 381 20.484 -5.918 98.866 19.68 C
ATOM 1796 CB LEU 381 19.416 -6.243 97.824 17.69 C
ATOM 1797 CG LEU 381 19.981 -6.967 96.600 18.29 C
ATOM 1798 CDl LEU 381 18.856 -7.329 95.652 15.16 C
ATOM 1799 CD2 LEU 381 21.004 -6.081 95.896 17.34 C
ATOM 1800 C LEU 381 19.884 -5.156 100.039 19.97 C
ATOM 1801 O LEU 381 20.064 -3.944 100.149 21.87 O
ATOM 1802 N SER 382 19.187 -5.863 100.920 20.79 N
ATOM 1803 CA SER 382 18.589 -5.212 102.076 21.60 C
ATOM 1804 CB SER 382 17.917 -6.237 102.995 21.27 C
ATOM 1805 OG SER 382 16.716 -6.716 102.434 1.00 21.51 O ATOM 1806 C SER 382 19.656 -4.456 102.852 1.00 20.93 C
ATOM 1807 O SER 382 19.527 -3.253 103.081 1.00 23.23 O
ATOM 1808 N GLY 383 20.708 -5.166 103.250 1.00 20.46 N
ATOM 1809 CA GLY 383 21.786 -4.544 103.995 1.00 19.84 C
ATOM 1810 C GLY 383 22.380 -3.346 103.275 1.00 20.02 C
ATOM 1811 O GLY 383 22.559 -2.278 103.858 1.00 20.84 O
ATOM 1812 N LEU 384 22.684 -3.525 101.996 1.00 19.18 N
ATOM 1813 CA LEU 384 23.258 -2.457 101.200 1.00 20.06 C
ATOM 1814 CB LEU 384 23.632 -2.969 99.804 1.00 19.95 C
ATOM 1815 CG LEU 384 24.802 -3.960 99.686 1.00 18.33 C
ATOM 1816 CDl LEU 384 24.970 -4.384 98.236 1.00 16.33 C
ATOM 1817 CD2 LEU 384 26.087 -3.329 100.208 1.00 14.97 C
ATOM 1818 C LEU 384 22.307 -1.274 101.071 1.00 21.38 C
ATOM 1819 O LEU 384 22.745 -0.142 100.891 1.00 20.83 O
ATOM 1820 N LEU 385 21.008 -1.521 101.176 1.00 21.68 N
ATOM 1821 CA LEU 385 20.062 -0.425 101.044 1.00 21.72 C
ATOM 1822 CB LEU 385 18.936 -0.811 100.079 1.00 19.89 C
ATOM 1823 CG LEU 385 19.431 -1.146 98.665 1.00 21.61 C
ATOM 1824 CDl LEU 385 18.267 -1.510 97.780 1.00 21.57 C
ATOM 1825 CD2 LEU 385 20.194 0.045 98.077 1.00 21.80 C
ATOM 1826 C LEU 385 19.486 0.092 102.364 1.00 23.08 C
ATOM 1827 O LEU 385 18.414 0.693 102.388 1.00 21.57 O
ATOM 1828 N ILE 386 20.204 -0.129 103.459 1.00 23.36 N
ATOM 1829 CA ILE 386 19.743 0.360 104.749 1.00 25.55 C
ATOM 1830 CB ILE 386 20.571 -0.262 105.901 1.00 24.78 C
ATOM 1831 CG2 ILE 386 20.407 0.556 107.181 1.00 25.10 C
ATOM 1832 CGl ILE 386 20.127 -1.716 106.099 1.00 24.60 C
ATOM 1833 CDl ILE 386 20.926 -2.487 107.100 1.00 22.95 C
ATOM 1834 C ILE 386 19.859 1.898 104.747 1.00 27.19 C
ATOM 1835 O ILE 386 20.912 2.449 104.419 1.00 26.87 O
ATOM 1836 N LYS 387 18.760 2.570 105.090 1.00 26.87 N
ATOM 1837 CA LYS 387 18.696 4.031 105.108 1.00 28.64 C
ATOM 1838 CB LYS 387 17.348 4.513 105.676 1.00 28.54 C
ATOM 1839 CG LYS 387 16.104 3.864 105.068 1.00 31.02 C
ATOM 1840 CD LYS 387 16.025 4.040 103.559 1.00 31.30 C
ATOM 1841 CE LYS 387 14.734 3.435 103.014 1.00 32.21 C
ATOM 1842 NZ LYS 387 14.631 3.482 101.532 1.00 31.88 N
ATOM 1843 C LYS 387 19.831 4.654 105.922 1.00 28.80 C
ATOM 1844 O LYS 387 20.560 5.514 105.424 1.00 29.65 O
ATOM 1845 N ASP 388 19.974 4.232 107.173 1.00 26.89 N
ATOM 1846 CA ASP 388 21.036 4.767 108.011 1.00 27.39 C
ATOM 1847 CB ASP 388 20.784 4.458 109.488 1.00 25.08 C
ATOM 1848 CG ASP 388 21.794 5.136 110.398 1.00 27.00 C
ATOM 1849 ODl ASP 388 22.910 5.437 109.924 1.00 24.32 O
ATOM 1850 OD2 ASP 388 21.482 5.357 111.591 1.00 28.25 O
ATOM 1851 C ASP 388 22.370 4.163 107.590 1.00 26.56 C
ATOM 1852 O ASP 388 22.576 2.949 107.676 1.00 28.78 O
ATOM 1853 N PRO 389 23.294 5.014 107.133 1.00 26.04 N
ATOM 1854 CD PRO 389 23.071 6.466 107.074 1.00 24.63 C
ATOM 1855 CA PRO 389 24.643 4.679 106.668 1.00 26.32 C
ATOM 1856 CB PRO 389 25.144 6.002 106.104 1.00 27.24 C
ATOM 1857 CG PRO 389 24.484 7.005 107.006 1.00 24.68 C
ATOM 1858 C PRO 389 25.563 4.152 107.757 1.00 27.61 C
ATOM 1859 O PRO 389 26.655 3.681 107.473 1.00 29.39 O
ATOM 1860 N ASN 390 25.125 4.239 109.004 1.00 28.84 N
ATOM 1861 CA ASN 390 25.935 3.764 110.116 1.00 29.78 C
ATOM 1862 CB ASN 390 25.596 4.538 111.384 1.00 31.55 C
ATOM 1863 CG ASN 390 25.984 5.981 111.287 1.00 32.84 C
ATOM 1864 ODl ASN 390 25.256 6.866 111.740 1.00 34.24 O
ATOM 1865 ND2 ASN 390 27.146 6.237 110.695 1.00 33.31 N
ATOM 1866 C ASN 390 25.726 2.293 110.360 1.00 28.76 C
ATOM 1867 O ASN 390 26.572 1.629 110.944 1.00 29.37 O
ATOM 1868 N LYS 391 24.591 1.780 109.917 1.00 28.53 N
ATOM 1869 CA LYS 391 24.309 0.373 110.115 1.00 29.64 C
ATOM 1870 CB LYS 391 23.139 0.224 111.077 1.00 31.05 C
ATOM 1871 CG LYS 391 21.967 1.075 110.713 1.00 32.11 C
ATOM 1872 CD LYS 391 21.045 1.194 111.894 1.00 34.41 C
ATOM 1873 CE LYS 391 21.767 1.821 113.064 1.00 37.35 C
ATOM 1874 NZ LYS 391 20.828 2.145 114.176 1.00 38.16 N
ATOM 1875 C LYS 391 24.013 -0.325 108.800 1.00 29.00 C
ATOM 1876 O LYS 391 23.443 -1.417 108.774 1.00 27.47 O
ATOM 1877 N ARG 392 24.403 0.321 107.707 1.00 28.01 N
ATOM 1878 CA ARG 392 24.197 -0.239 106.385 1.00 27.27 C ATOM 1879 CB ARG 392 24.291 0.866 105.332 1.00 26.70 C
ATOM 1880 CG ARG 392 23.974 0.420 103.915 1.00 25.94 C
ATOM 1881 CD ARG 392 23.308 1.549 103.154 1.00 25.73 C
ATOM 1882 NE ARG 392 24.236 2.609 102.799 1.00 23.15 N
ATOM 1883 CZ ARG 392 23.968 3.909 102.893 1.00 25.11 C
ATOM 1884 NHl ARG 392 22.791 4.331 103.344 1.00 20.63 N
ATOM 1885 NH2 ARG 392 24.881 4.792 102.518 1.00 22.82 N
ATOM 1886 C ARG 392 25.311 -1.247 106.174 1.00 26.85 C
ATOM 1887 O ARG 392 26.417 -1.031 106.641 1.00 27.91 O
ATOM 1888 N LEU 393 25.031 -2.349 105.487 1.00 25.04 N
ATOM 1889 CA LEU 393 26.074 -3.331 105.240 1.00 23.24 C
ATOM 1890 CB LEU 393 25.572 -4.422 104.301 1.00 22.07 C
ATOM 1891 CG LEU 393 26.585 -5.551 104.096 1.00 24.89 C
ATOM 1892 CDl LEU 393 26.874 -6.240 105.428 1.00 24.23 C
ATOM 1893 CD2 LEU 393 26.042 -6.547 103.087 1.00 24.54 C
ATOM 1894 C LEU 393 27.301 -2.649 104.628 1.00 23.34 C
ATOM 1895 O LEU 393 27.200 -1.947 103.620 1.00 21.20 O
ATOM 1896 N GLY 394 28.458 -2.848 105.253 1.00 22.91 N
ATOM 1897 CA GLY 394 29.678 -2.243 104.748 1.00 22.26 C
ATOM 1898 C GLY 394 29.944 -0.861 105.320 1.00 24.34 C
ATOM 1899 O GLY 394 30.976 -0.255 105.030 1.00 23.96 O
ATOM 1900 N GLY 395 29.015 -0.368 106.137 1.00 23.96 N
ATOM 1901 CA GLY 395 29.164 0.941 106.748 1.00 24.33 C
ATOM 1902 C GLY 395 29.920 0.931 108.069 1.00 24.27 C
ATOM 1903 O GLY 395 30.233 1.987 108.618 1.00 22.28 O
ATOM 1904 N GLY 396 30.206 -0.262 108.587 1.00 24.77 N
ATOM 1905 CA GLY 396 30.949 -0.367 109.836 1.00 24.01 C
ATOM 1906 C GLY 396 32.430 -0.054 109.656 1.00 23.80 C
ATOM 1907 O GLY 396 32.859 0.373 108.581 1.00 23.07 O
ATOM 1908 N PRO 397 33.245 -0.258 110.695 1.00 22.46 N
ATOM 1909 CD PRO 397 32.859 -0.639 112.062 1.00 22.48 C
ATOM 1910 CA PRO 397 34.680 0.019 110.615 1.00 22.47 C
ATOM 1911 CB PRO 397 35.120 -0.058 112.075 1.00 23.99 C
ATOM 1912 CG PRO 397 34.179 -1.052 112.657 1.00 22.42 C
ATOM 1913 C PRO 397 35.497 -0.898 109.701 1.00 22.14 C
ATOM 1914 O PRO 397 36.603 -0.545 109.297 1.00 21.67 O
ATOM 1915 N ASP 398 34.974 -2.072 109.372 1.00 22.01 N
ATOM 1916 CA ASP 398 35.733 -2.948 108.498 1.00 22.21 C
ATOM 1917 CB ASP 398 35.522 -4.414 108.885 1.00 23.69 C
ATOM 1918 CG ASP 398 36.839 -5.176 108.996 1.00 23.19 C
ATOM 1919 ODl ASP 398 37.889 -4.516 109.084 1.00 26.09 O
ATOM 1920 OD2 ASP 398 36.834 -6.421 108.998 1.00 23.27 O
ATOM 1921 C ASP 398 35.410 -2.704 107.021 1.00 23.91 C
ATOM 1922 O ASP 398 35.940 -3.370 106.137 1.00 24.26 O
ATOM 1923 N ASP 39£ 34.538 -1.734 106.761 1.00 23.90 N
ATOM 1924 CA ASP 399 34.186 -1.371 105.392 1.00 24.15 C
ATOM 1925 CB ASP 399 35.332 -0.540 104.788 1.00 24.34 C
ATOM 1926 CG ASP 399 34.937 0.171 103.505 1.00 25.48 C
ATOM 1927 ODl ASP 399 34.006 1.001 103.545 1.00 24.62 O
ATOM 1928 OD2 ASP 399 35.556 -0.092 102.456 1.00 25.27 O
ATOM 1929 C ASP 399 33.869 -2.573 104.484 1.00 22.70 C
ATOM 1930 O ASP 399 33.009 -3.395 104.794 1.00 21.69 O
ATOM 1931 N ALA 400 34.572 -2.661 103.362 1.00 21.11 N
ATOM 1932 CA ALA 400 34.364 -3.729 102.390 1.00 20.82 C
ATOM 1933 CB ALA 400 35.437 -3.656 101.332 1.00 21.13 C
ATOM 1934 C ALA 400 34.290 -5.149 102.960 1.00 22.52 C
ATOM 1935 O ALA 400 33.468 -5.950 102.521 1.00 23.54 O
ATOM 1936 N LYS 401 35.139 -5.459 103.936 1.00 23.06 N
ATOM 1937 CA LYS 401 35.155 -6.789 104.535 1.00 24.03 C
ATOM 1938 CB LYS 401 36.102 -6.818 105.746 1.00 27.60 C
ATOM 1939 CG LYS 401 37.602 -6.770 105.412 1.00 31.00 C
ATOM 1940 CD LYS 401 37.987 -5.487 104.673 1.00 34.30 C
ATOM 1941 CE LYS 401 39.495 -5.423 104.392 1.00 35.75 C
ATOM 1942 NZ LYS 401 39.871 -4.155 103.689 1.00 37.76 N
ATOM 1943 C LYS 401 33.780 -7.316 104.960 1.00 23.56 C
ATOM 1944 O LYS 401 33.512 -8.509 104.838 1.00 24.04 O
ATOM 1945 N GLU 402 32.913 -6.441 105.465 1.00 22.59 N
ATOM 1946 CA GLU 402 31.590 -6.877 105.902 1.00 22.41 C
ATOM 1947 CB GLU 402 30.775 -5.716 106.476 1.00 23.12 C
ATOM 1948 CG GLU 402 31.498 -4.870 107.502 1.00 25.18 C
ATOM 1949 CD GLU 402 30.592 -3.857 108.172 1.00 25.99 C
ATOM 1950 OEl GLU 402 31.112 -3.057 108.976 1.00 29.43 O
ATOM 1951 OE2 GLU 402 29.369 -3.863 107.908 1.00 25.42 O ATOM 1952 C GLU 402 30.844 -7.457 104.718 21.66 C
ATOM 1953 O GLU 402 30.163 -8.464 104.830 20.66 O
ATOM 1954 N ILE 403 30.975 -6.806 103.574 22.60 N
ATOM 1955 CA ILE 403 30.314 -7.276 102.373 22.07 C
ATOM 1956 CB ILE 403 30.330 -6.182 101.299 22.47 C
ATOM 1957 CG2 ILE 403 29.630 -6.663 100.057 23.62 C
ATOM 1958 CGl ILE 403 29.661 -4.920 101.847 20.26 C
ATOM 1959 CDl ILE 403 29.886 -3.702 101.015 20.96 C
ATOM I960 C ILE 403 31.031 -8.532 101.882 22.70 C
ATOM 1961 O ILE 403 30.392 -9.503 101.466 23.89 O
ATOM 1962 N MET 404 32.359 -8.524 101.965 21.48 N
ATOM 1963 CA MET 404 33.158 -9.667 101.534 20.68 C
ATOM 1964 CB MET 404 34.650 -9.349 101.668 19.41 C
ATOM 1965 CG MET 404 35.152 -8.346 100.628 22.67 C
ATOM 1966 SD MET 404 36.901 -7.889 100.805 22.27 S
ATOM 1967 CE MET 404 37.686 -9.436 100.666 25.18 C
ATOM 1968 C MET 404 32.812 -10.938 102.318 20.42 C
ATOM 1969 O MET 404 32.861 -12.043 101.780 18.99 O
ATOM 1970 N ARG 405 32.444 -10.777 103.581 18.43 N
ATOM 1971 CA ARG 405 32.094 -11.924 104.402 21.53 C
ATOM 1972 CB ARG 405 32.498 -11.688 105.865 20.53 C
ATOM 1973 CG ARG 405 34.001 -11.458 106.084 21.07 C
ATOM 1974 CD ARG 405 34.329 -11.325 107.562 21.43 C
ATOM 1975 NE ARG 405 33.628 -10.215 108.206 20.80 N
ATOM 1976 CZ ARG 405 34.166 -9.022 108.448 22.97 C
ATOM 1977 NHl ARG 405 35.419 -8.775 108.102 23.30 N
ATOM 1978 NH2 ARG 405 33.452 -8.073 109.037 1..00 21.98 N
ATOM 1979 C ARG 405 30.613 -12.274 104.340 21.16 C
ATOM 1980 O ARG 405 30.183 -13.239 104.965 20.31 O
ATOM 1981 N HIS 406 29.830 -11.494 103.602 20.51 N
ATOM 1982 CA HIS 406 28.400 -11.777 103.505 21.34 C
ATOM 1983 CB HIS 406 27.674 -10.652 102.754 21.51 C
ATOM 1984 CG HIS 406 26.185 -10.747 102.832 22.21 C
ATOM 1985 CD2 HIS 406 25.296 -10.111 103.629 19.91 C
ATOM 1986 NDl HIS 406 25.454 -11.643 102.079 22.53 N
ATOM 1987 CEl HIS 406 24.180 -11.559 102.414 24.63 C
ATOM 1988 NE2 HIS 406 24.057 -10.637 103.353 23.74 N
ATOM 1989 C HIS 406 28.199 -13.124 102.799 21.18 C
ATOM 1990 O HIS 406 28.934 -13.462 101.860 20.75 O
ATOM 1991 N SER 407 27.209 -13.891 103.256 21.30 N
ATOM 1992 CA SER 407 26.943 -15.221 102.698 20.75 C
ATOM 1993 CB SER 407 25.825 -15.920 103.492 20.28 C
ATOM 1994 OG SER 407 24.561 -15.373 103.207 24.71 O
ATOM 1995 C SER 407 26.643 -15.264 101.191 19.97 C
ATOM 1996 O SER 407 26.868 -16.284 100.542 18.08 O
ATOM 1997 N PHE 408 26.151 -14.163 100.635 18.81 N
ATOM 1998 CA PHE 408 25.879 -14.112 99.206 19.10 C
ATOM 1999 CB PHE 408 25.268 -12.755 98.818 21.05 C
ATOM 2000 CG PHE 408 24.965 -12.621 97.344- 21.60 C
ATOM 2001 CDl PHE 408 23.854 -13.234 96.790 20.37 C
ATOM 2002 CD2 PHE 408 25.835 -11.932 96.505 20.86 C
ATOM 2003 CEl PHE 408 23.612 -13.171 95.423 22.61 C
ATOM 2004 CE2 PHE 408 25.608 -11.860 95.137 1.00 21.38 C
ATOM 2005 CZ PHE 408 24.491 -12.484 94.589 23.60 C
ATOM 2006 C PHE 408 27.196 -14.337 98.455 19.81 C
ATOM 2007 O PHE 408 27.194 -14.768 97.305 20.80 O
ATOM 2008 N PHE 409 28.318 -14.058 99.116 19.13 N
ATOM 2009 CA PHE 409 29.645 -14.234 98.518 19.54 C
ATOM 2010 CB PHE 409 30.488 -12.952 98.639 17.27 C
ATOM 2011 CG PHE 409 29.970 -11.790 97.848 18.84 C
ATOM 2012 CDl PHE 409 29.963 -11.819 96.463 20.49 C
ATOM 2013 CD2 PHE 409 29.522 -10.646 98.490 20.61 C
ATOM 2014 CEl PHE 409 29.524 -10.730 95.729 23.77 C
ATOM 2015 CE2 PHE 409 29.075 -9.542 97.764 23.73 C
ATOM 2016 CZ PHE 409 29.077 -9.583 96.381 22.42 C
ATOM 2017 C PHE 409 30.418 -15.351 99.220 20.56 C
ATOM 2018 O PHE 409 31.638 -15.415 99.114 19.62 O
ATOM 2019 N SER 410 29.712 -16.223 99.927 20.44 N
ATOM 2020 CA SER 410 30.355 -17.293 100.676 22.38 C
ATOM 2021 CB SER 410 29.309 -18.123 101.423 21.00 C
ATOM 2022 OG SER 410 28.612 -18.980 100.538 21.78 O
ATOM 2023 C SER 410 31.246 -18.238 99.872 24.35 C
ATOM 2024 O SER 410 32.107 -18.899 100.442 1.00 27.02 O ATOM 2025 N GLY 411 31.046 -18.329 98.564 1.00 24.04 N
ATOM 2026 CA GLY 411 31.882 -19.226 97.786 1.00 22.77 C
ATOM 2027 C GLY 411 32.982 -18.517 97.013 1.00 23.58 C
ATOM 2028 O GLY 411 33.678 -19.145 96.214 1.00 23.55 O
ATOM 2029 N VAL 412 33.142 -17.218 97.270 1.00 22.22 N
ATOM 2030 CA VAL 412 34.117 -16.382 96.580 1.00 21.66 C
ATOM 2031 CB VAL 412 33.569 -14.947 96.400 1.00 22.88 C
ATOM 2032 CGl VAL 412 34.618 -14.067 95.745 1.00 22.00 C
ATOM 2033 CG2 VAL 412 32.292 -14.970 95.566 1.00 25.26 C
ATOM 2034 C VAL 412 35.501 -16.253 97.206 1.00 21.46 C
ATOM 2035 O VAL 412 35.634 -15.975 98.397 1.00 21.51 O
ATOM 2036 N ASN 413 36.531 -16.452 96.387 1.00 21.04 N
ATOM 2037 CA ASN 413 37.919 -16.297 96.831 1.00 20.86 C
ATOM 2038 CB ASN 413 38.835 -17.317 96.152 1.00 18.90 C
ATOM 2039 CG ASN 413 40.253 -17.296 96.714 1.00 20.04 C
ATOM 2040 ODl ASN 413 40.965 -16.299 96.595 1.00 19.48 O
ATOM 2041 ND2 ASN 413 40.661 -18.394 97.335 1.00 17.94 N
ATOM 2042 C ASN 413 38.292 -14.873 96.413 1.00 21.31 C
ATOM 2043 O ASK 413 38.426 -14.561 95.227 1.00 21.45 O
ATOM 2044 N TRP 414 38.435 -13.999 97.394 1.00 22.43 N
ATOM 2045 CA TRP 414 38.729 -12.608 97.104 1.00 23.15 C
ATOM 2046 CB TRP 414 38.488 -11.769 98.357 1.00 22.07 C
ATOM 2047 CG TRP 414 37.027 -11.686 98.635 1.00 21.17 C
ATOM 2048 CD2 TRP 414 36.084 -10.834 97.969 1.00 19.34 C
ATOM 2049 CE2 TRP 414 34.797 -11.186 98.436 1.00 18.31 C
ATOM 2050 CE3 TRP 414 36.205 -9.813 97.019 1.00 17.40 C
ATOM 2051 CDl TRP 414 36.293 -12.494 99.464 1.00 21.66 C
ATOM 2052 NEl TRP 414 34.952 -12.199 99.344 1.00 20.69 N
ATOM 2053 CZ2 TRP 414 33.642 -10.552 97.984 1.00 19.19 C
ATOM 2054 CZ3 TRP 414 35.062 -9.185 96.572 1.00 17.84 C
ATOM 2055 CH2 TRP 414 33.793 -9.556 97.054 1.00 18.45 C
ATOM 2056 C TRP 414 40.070 -12.280 96.467 1.00 24.53 C
ATOM 2057 O TRP 414 40.166 -11.301 95.729 1.00 24.80 O
ATOM 2058 N GLN 415 41.096 -13.086 96.720 1.00 25.45 N
ATOM 2059 CA GLN 415 42.402 -12.831 96.102 1.00 25.52 C
ATOM 2060 CB GLN 415 . 43.479 -13.735 96.712 1.00 27.33 C
ATOM 2061 CG GLN 415 44.898 -13.429 96.245 1.00 29.32 C
ATOM 2062 CD GLN 415 45.317 -11.981 96.514 1.00 30.67 C
ATOM 2063 OEl GLN 415 45.378 -11.156 95.604 1.00 30.62 O
ATOM 2064 NE2 GLN 415 45.597 -11.673 97.774 1.00 31.33 N
ATOM 2065 C GLN 415 42.276 -13.095 94.593 1.00 25.93 C
ATOM 2066 O GLN 415 42.846 -12.362 93.767 1.00 23.89 O
ATOM 2067 N ASP 416 41.521 -14.136 94.236 1.00 23.86 N
ATOM 2068 CA ASP 416 41.307 -14.447 92.824 1.00 24.69 C
ATOM 2069 CB ASP 416 40.568 -15.777 92.656 1.00 24.51 C
ATOM 2070 CG ASP 416 41.490 -16.975 92.111 1.00 26.17 C
ATOM 2071 ODl ASP 416 42.712 -16.813 92.562 1.00 27.83 O
ATOM 2072 OD2 ASP 416 40.990 -18.077 93.069 1.00 23.31 O
ATOM 2073 C ASP 416 40.524 -13.330 92.122 1.00 23.80 C
ATOM 2074 O ASP 416 40.734 -13.065 90.944 1.00 22.96 O
ATOM 2075 N VAL 417 39.616 -12.680 92.842 1.00 22.30 N
ATOM 2076 CA VAL 417 38.854 -11.586 92.252 1.00 22.19 C
ATOM 2077 CB VAL 417 37.939 -10.921 93.299 1.00 21.53 C
ATOM 2078 CGl VAL 417 37.342 -9.634 92.733 1.00 19.11 C
ATOM 2079 CG2 VAL 417 36.840 -11.898 93.714 1.00 19.57 C
ATOM 2080 C VAL 417 39.832 -10.543 91.708 1.00 22.86 C
ATOM 2081 O VAL 417 39.859 -10.256 90.513 1.00 22.19 O
ATOM 2082 N TYR 418 40.646 -9.998 92.604 1.00 24.63 N
ATOM 2083 CA TYR 418 41.638 -8.986 92.258 1.00 25.30 C
ATOM 2084 CB TYR 418 42.449 -8.618 93.494 1.00 25.99 C
ATOM 2085 CG TYR 418 43.411 -7.496 93.244 1.00 27.98 C
ATOM 2086 CDl TYR 418 42.965 -6.179 93.141 1.00 28.12 C
ATOM 2087 CEl TYR 418 43.844 -5.146 92.877 1.00 28.27 C
ATOM 2088 CD2 TYR 418 44.764 -7.751 93.076 1.00 28.84 C
ATOM 2089 CE2 TYR 418 45.650 -6.737 92.814 1.00 30.95 C
ATOM 2090 C3 TYR 418 45.192 -5.432 92.713 1.00 30.84 C
ATOM 2091 OH TYR 418 46.097 -4.431 92.440 1.00 30.89 O
ATOM 2092 C TYR 418 42.597 -9.433 91.156 1.00 24.45 C
ATOM 2093 O TYR 418 43.002 -8.636 90.313 1.00 24.67 O
ATOM 2094 N ASP 419 42.963 -10.709 91.171 1.00 24.89 N
ATOM 2095 CA ASP 419 43.875 -11.241 90.170 1.00 24.56 C
ATOM 2096 CB ASP 419 44.642 -12.433 90.727 1.00 22.66 C
ATOM 2097 CG ASP 419 45.675 -12.019 91.749 . 1.00 26.08 C ATOM 2098 ODl ASP 419 46.403 -11.042 91.473 1.00 27.34 O
ATOM 2099 OD2 ASP 419 45.765 -12.661 92.820 1.00 25.56 O
ATOM 2100 C ASP 419 43.160 -11.634 88.894 1.00 25.47 C
ATOM 2101 O ASP 419 43.764 -12.191 87.979 1.00 25.70 O
ATOM 2102 N LYS 420 41.872 -11.328 88.833 1.00 24.80 N
ATOM 2103 CA LYS 420 41.079 -11.631 87.658 1.00 25.42 C
ATOM 2104 CB LYS 420 41.548 -10.766 86.485 1.00 26.36 C
ATOM 2105 CG LYS 420 41.585 -9.269 86.802 1.00 28.09 C
ATOM 210S CD LYS 420 41.631 -8.418 85.533 1.00 28.27 C
ATOM 2107 CE LYS 420 42.927 -8.610 84.764 1.00 27.11 C
ATOM 2108 NZ LYS 420 42.814 -8.057 83.387 1.00 27.30 N
ATOM 2109 C LYS 420 41.183 -13.106 87.299 1.00 25.94 C
ATOM 2110 O LYS 420 41.308 -13.464 86.139 1.00 24.51 O
ATOM 2111 N LYS 421 41.132 -13.961 88.311 1.00 27.46 N
ATOM 2112 CA LYS 421 41.216 -15.391 88.093 1.00 29.35 C
ATOM 2113 CB LYS 421 41.970 -16.061 89.251 1.00 .31.50 C
ATOM 2114 CG LYS 421 43.487 -15.818 89.269 1.00 32.49 C
ATOM 2115 CD LYS 421 44.246 -16.972 88.618 1.00 33.69 C
ATOM 2116 CE LYS 421 45.766 -16.933 88.909 1.00 36.08 C
ATOM 2117 NZ LYS 421 46.564 -16.059 87.980 1.00 36.72 N
ATOM 2118 C LYS 421 39.826 -15.995 87.944 1.00 29.61 C
ATOM 2119 O LYS 421 39.684 -17.134 87.516 1.00 32.40 O
ATOM 2120 N LEU 422 38.789 -15.251 88.299 1.00 30.50 N
ATOM 2121 CA LEU 422 37.446 -15.793 88.137 1.00 30.25 C
ATOM 2122 CB LEU 422 36.439 -15.025 88.980 1.00 30.66 C
ATOM 2123 CG LEU 422 36.496 -15.310 90.476 1.00 33.45 C
ATOM 2124 CDl LEU 422 37.881 -14.928 91.003 1.00 35.34 C
ATOM 2125 CD2 LEU 422 35.413 -14.513 91.193 1.00 33.52 C
ATOM 2126 C LEU 422 37.028 -15.726 86.675 1.00 29.46 C
ATOM 2127 O LEU 422. 37.299 -14.746 85.986 1.00 29.89 O
ATOM 2128 N VAL 423 36.371 -16.776 86.206 1.00 30.02 N
ATOM 2129 CA VAL 423 35.896 -16.832 84.827 1.00 29.01 C
ATOM 2130 CB VAL 423 35.508 -18.254 84.433 1.00 29.73 C
ATOM 2131 CGl VAL 423 35.011 -18.274 82.986 1.00 27.90 C
ATOM 2132 CG2 VAL 423 36.700 -19.181 84.634 1.00 30.93 C
ATOM 2133 C VAL 423 34.657 -15.967 84.680 1.00 28.69 C
ATOM 2134 O VAL 423 33.697 -16.116 85.437 1.00 29.83 O
ATOM 2135 N PRO 424 34.670 -15.038 83.719 1.00 27.68 N
ATOM 2136 CD PRO 424 35.857 -14.541 83.004 1.00 27.33 C
ATOM 2137 CA PRO 424 33.515 -14.161 83.503 1.00 27.70 C
ATOM 2138 CB PRO 424 34.049 -13.119 82.521 1.00 27.65 C
ATOM 2139 CG PRO 424 35.541 -13.077 82.853 1.00 27.81 C
ATOM 2140 C PRO 424 32.324 -14.939 82.940 1.O0 28.26 C
ATOM 2141 O PRO 424 32.478 -15.798 82.073 1.00 29.66 O
ATOM 2142 N PRO 425 31.124 -14.662 83.453 1.00 29.27 N
ATOM 2143 CD PRO 425 30.883 -13.768 84.594 1.00 29.32 C
ATOM 2144 CA PRO 425 29.878 -15.309 83.030 1.00 29.60 C
ATOM 2145 CB PRO 425 28.829 -14.651 83.919 1.00 29.85 C
ATOM 2146 CG PRO 425 29.605 -14.328 85.158 1.00 30.56 C
ATOM 2147 C PRO 425 29.600 -15.064 81.551 1.00 29.61 C
ATOM 2148 O PRO 425 29.180 -15.965 80.840 1.00 30.34 O
ATOM 2149 N PHE 426 29.837 -13.836 81.102 1.00 29.69 N
ATOM 2150 CA PHE 426 29.627 -13.458 79.709 1.00 29.00 C
ATOM 2151 CB PHE 426 28.647 -12.292 79.608 1.00 29.64 C
ATOM 2152 CG PHE 426 28.690 -11.580 78.279 1.00 31.36 C
ATOM 2153 CDl PHE 426 28.087 -12.125 77.161 1.00 31.31 C
ATOM 2154 CD2 PHE 426 29.364 -10.381 78.148 1.00 30.93 C
ATOM 2155 CEl PHE 426 28.156 -11.489 75.935 1.00 32.12 C
ATOM 2156 CE2 PHE 426 29.439 -9.742 76.935 1.00 31.94 C
ATOM 2157 CZ PHE 426 28.834 -10.295 75.820 1.00 32.03 C
ATOM 2158 C PHE 426 30.937 -13.032 79.085 1.00 28.88 C
ATOM 2159 O PHE 426 31.604 -12.147 79.606 1.00 28.84 O
ATOM 2160 N LYS 427 31.305 -13.651 77.968 1.00 29.00 N
ATOM 2161 CA LYS 427 32.555 -13.300 77.289 1.00 30.31 C
ATOM 2162 CB LYS 427 33.298 -14.555 76.834 1.00 30.60 C
ATOM 2163 CG LYS 427 34.483 -14.271 75.893 1.00 35.61 C
ATOM 2164 CD LYS 427 35.525 -13.360 76.548 1.00 36.89 C
ATOM 2165 CE LYS 427 36.716 -13.040 75.635 1.00 36.98 C
ATOM 2166 NZ LYS 427 36.409 -12.098 74.513 1.00 36.83 N
ATOM 2167 C LYS 427 32.317 -12.408 76.078 1.00 31.26 C
ATOM 2168 O LYS 427 31.642 -12.809 75.127 1.00 30.69 O
ATOM 2169 N PRO 428 32.869 -11.183 76.100 1.00 32.12 N
ATOM 2170 CD PRO 428 33.599 -10.556 77.213 1.00 33.67 C ATOM 2171 CA PRO 428 32.718 -10.234 74.997 00 33.58 C
ATOM 2172 CB PRO 428 33.510 -9.021 75.479 00 34.14 C
ATOM 2173 CG PRO 428 33.356 -9.085 76.953 00 32.67 C
ATOM 2174 C PRO 428 33.308 -10.849 73.729 00 34.62 C
ATOM 2175 O PRO 428 34.470 -11.246 73.703 00 33.59 O
ATOM 2176 N GLN 429 32.489 -10.923 72.686 00 35.47 N
ATOM 2177 CA GLN 429 32.892 -11.513 71.419 00 37.07 C
ATOM 2178 CB GLN 429 31.651 -12.055 70.703 00 38.27 C
ATOM 2179 CG GLN 429 31.125 -13.328 71.330 00 41.48 C
ATOM 2180 CD GLN 429 32.047 -14.507 71.061 00 43.32 C
ATOM 2181 OKI GLN 429 32.018 -15.102 69.973 1.00 43.78 O
ATOM 2182 NE2 GLN 429 32.891 -14.833 72.034 1.00 44.52 N
ATOM 2183 C GLN 429 33.671 -10.591 70.491 36.56 C
ATOM 2184 O GLN 429 33.452 -10.594 69.279 36.93 O
ATOM 2185 N VAL 430 34.588 -9.811 71.054 37.01 N
ATOM 2186 CA VAL 430 35.391 -8.916 70.240 37.04 C
ATOM 2187 CB VAL 430 36.135 -7.881 71.101 36.75 C
ATOM 2188 CGl VAL 430 35.132 -7.002 71.819 35.21 C
ATOM 2189 CG2 VAL 430 37.052 -8.584 72.098 34.54 C
ATOM 2190 C VAL 430 36.392 -9.748 69.450 38.83 C
ATOM 2191 O VAL 430 36.911 -10.756 69.929 40.27 O
ATOM 2192 N THR 431 36.667 -9.321 68.230 39.74 N
ATOM 2193 CA THR 431 37.575 -10.044 67.358 40.50 C
ATOM 2194 CB THR 431 36.873 -10.322 66.022 1.00 41.07 C
ATOM 2195 OGl THR 431 36.375 -9.084 65.493 41.01 O
ATOM 2196 CG2 THR 431 35.696 -11.266 66.221 39.58 C
ATOM 2197 C THR 431 38.884 -9.296 67.078 41.30 C
ATOM 2198 O THR 431 39.560 -9.578 66.087 41.95 O
ATOM 2199 N SER 432 39.241 -8.339 67.930 41.22 N
ATOM 2200 CA SER 432 40.475 -7.595 67.718 42.36 C
ATOM 2201 CB SER 432 40.536 -7.043 66.285 1.00 43.27 C
ATOM 2202 OG SER 432 39.881 -5.785 66.177 41.78 O
ATOM 2203 C SER 432 40.668 -6.438 68.685 42.88 C
ATOM 2204 O SER 432 39.718 -5.9,49 69.299 43.38 O
ATOM 2205 N GLU 433 41.916 -5.992 68.782 43.27 N
ATOM 2206 CA GLU 433 42.299 -4.882 69.648 44.20 C
ATOM 2207 CB GLU 433 43.594 -4.253 69.109 45.69 C
ATOM 2208 CG GLU 433 44.373 -3.448 70.126 46.53 C
ATOM 2209 CD GLU 433 44.897 -4.315 71.249 48.43 C
ATOM 2210 OEl GLU 433 44.065 -4.963 71.924 1.00 49.43 O
ATOM 2211 OE2 GLU 433 46.134 -4.357 71.455 1.00 49.64 O
ATOM 2212 C GLU 433 41.193 -3.816 69.703 1.00 43.18 C
ATOM 2213 O GLU 433 40.843 -3.309 70.769 42.42 O
ATOM 2214 N THR 434 40.644 -3.505 68.540 42.35 N
ATOM 2215 CA THR 434 39.606 -2.492 68.401 42.82 C
ATOM 2216 CB THR 434 39.806 -1.701 67.133 44.38 C
ATOM 2217 OGl THR 434 41.137 -1.160 67.097 44.88 O
ATOM 2218 CG2 THR 434 38.747 -0.613 67.043 44.66 C
ATOM 2219 C THR 434 38.191 -3.043 68.292 1.00 41.95 C
ATOM 2220 0 THR 434 37.348 -2.926 69.200 44.26 O
ATOM 2221 N ASP 435 37.941 -3.626 67.135 39.52 N
ATOM 2222 CA ASP 435 36.649 -4.183 66.824 37.71 C
ATOM 2223 CB ASP 435 36.305 -5.266 67.822 36.20 C
ATOM 2224 CG ASP 435 35.050 -5.973 67.459 35.43 C
ATOM 2225 ODl ASP 435 35.063 -7.217 67.378 35.95 O
ATOM 2226 OD2 ASP 435 34.049 -5.270 67.252 36.75 O
ATOM 2227 C ASP 435 35.579 -3.082 66.810 36.43 C
ATOM 2228 O ASP 435 35.063 -2.734 65.738 38.45 O
ATOM 2229 N THR 436 35.259 -2.527 67.976 32.78 N
ATOM 2230 CA THR 436 34.261 -1.453 68.084 31.41 C
ATOM 2231 CB THR 436 34.471 -0.368 66.982 31.09 C
ATOM 2232 OGl THR 436 34.367 0.939 67.566 34.43 O
ATOM 2233 CG2 THR 436 33.412 -0.488 65.892 29.54 C
ATOM 2234 C THR 436 32.804 -1.931 68.006 30.14 C
ATOM 2235 O THR 436 31.875 -1.181 68.317 28.83 O
ATOM 2236 N ARG 437 32.612 -3.183 67.607 28.20 N
ATOM 2237 CA ARG 437 31.271 -3.735 67.468 30.54 C
ATOM 2238 CB ARG 437 31.339 -5.257 67.320 30.39 C
ATOM 2239 CG ARG 437 31.601 -5.993 68.611 32.98 C
ATOM 2240 CD ARG 437 31.559 -7.496 68.413 34.97 C
ATOM 2241 NE ARG 437 32.663 -7.956 67.580 36.29 N
ATOM 2242 CZ ARG 437 32.538 -8.322 66.310 37.09 C
ATOM 2243 NHl ARG 437 31.349 -8.292 65.717 1.00 38.62 N ATOM 2244 NH2 ARG 437 33.608 -8.704 65.625 1.00 38.50 N
ATOM 2245 C ARG 437 30.295 -3.380 68.593 1.00 30.07 C
ATOM 2246 O ARG 437 29.131 -3.083 68.332 1.00 30.30 O
ATOM 2247 N TYR 438 30.761 -3.401 69.837 1.00 29.30 N
ATOM 2248 CA TYR 438 29.880 -3.101 70.954 1.00 29.76 C
ATOM 2249 CB TYR 438 30.488 -3.627 72.253 1.00 28.29 C
ATOM 2250 CG TYR 438 30.320 -5.124 72.350 1.00 27.71 C
ATOM 2251 CDl TYR 438 29.052 -5.689 72.482 1.00 25.97 C
ATOM 2252 CEl TYR 438 28.877 -7.060 72.458 1.00 26.84 C
ATOM 2253 CD2 TYR 438 31.407 -5.976 72.205 1.00 26.83 C
ATOM 2254 CE2 TYR 438 31.240 -7.348 72.181 1.00 27.19 C
ATOM 2255 CZ TYR 438 29.978 -7.883 72.306 1.00 28.00 C
ATOM 2256 OH TYR 438 29.825 -9.246 72.265 1.00 30.59 O
ATOM 2257 C TYR 438 29.447 -1.651 71.101 1.00 30.56 C
ATOM 2258 O TYR 438 28.608 -1.330 71.935 1.00 31.66 O
ATOM 2259 N PHE 439 30.009 -0.772 70.290 1.00 30.39 N
ATOM 2260 CA PHE 439 29.603 0.619 70.339 1.00 32.68 C
ATOM 2261 CB PHE 439 30.831 1.535 70.478 1.00 32.41 C
ATOM 2262 CG PHE 439 31.660 1.239 71.701 1.00 31.97 C
ATOM 2263 CDl PHE 439 32.798 0.442 71.617 1.00 31.42 C
ATOM 2264 CD2 PHE 439 31.266 1.702 72.949 1.00 30.11 C
ATOM 2265 CEl PHE 439 33.528 0.110 72.760 1.00 30.63 C
ATOM 2266 CE2 PHE 439 31.988 1.371 74.086 1.00 31.07 C
ATOM 2267 CZ PHE 439 33.122 0.572 73.991 1.00 30.95 C
ATOM 2268 C PHE 439 28.826 0.898 69.052 1.00 33.62 C
ATOM 2269 O PHE 439 28.226 1.948 68.896 1.00 34.00 O
ATOM 2270 N ASP 440 28.853 -0.067 68.136 1.00 36.79 N
ATOM 2271 CA ASP 440 28.134 0.023 66.870 1.00 40.58 C
ATOM 2272 CB ASP 440 28.662 -1.013 65.858 1.00 39.56 C
ATOM 2273 CG ASP 440 29.955 -0.582 65.170 1.00 40.18 C
ATOM 2274 ODl ASP 440 30.583 0.413 65.607 1.00 39.84 O
ATOM 2275 OD2 ASP 440 30.350 -1.259 64.188 1.00 38.26 O
ATOM 2276 C ASP 440 26.665 -0.289 67.176 1.00 43.96 C
ATOM 2277 O ASP 440 26.097 0.242 68.135 1.00 44.15 O
ATOM 2278 N ALA 441 26.066 -1.180 66.383 1.00 48.16 N
ATOM 2279 CA ALA 441 24.657 -1.542 66.558 1.00 50.98 C
ATOM 2280 CB ALA 441 24.468 -2.300 67.874 1.00 51.36 C
ATOM 2281 C ALA 441 23.863 -0.239 66.583 1.00 52.22 C
ATOM 2282 O ALA 441 22.695 -0.215 66.984 1.00 52.66 O
ATOM 2283 N ALA 442 24.518 0.836 66.142 1.00 53.88 N
ATOM 2284 CA ALA 442 23.932 2.168 66.131 1.00 55.81 C
ATOM 2285 CB ALA 442 22.673 2.193 65.265 1.00 55.74 C
ATOM 2286 C ALA 442 23.597 2.472 67.591 1.00 57.73 C
ATOM 2287 O ALA 442 22.414 2.593 67.961 1.00 58.93 O
ATOM 2288 N ALA 443 24.643 2.586 68.417 1.00 58.41 N
ATOM 2289 CA ALA 443 24.490 2.852 69.852 1.00 58.73 C
ATOM 2290 CB ALA 443 23.658 4.116 70.077 1.00 58.80 C
ATOM 2291 C ALA 443 23.793 1.644 70.470 1.00 58.68 C
ATOM 2292 O ALA 443 24.435 0.659 70.848 1.00 58.79 O
ATOM 2293 N ALA 444 22.474 1.732 70.575 1.00 58.75 N
ATOM 2294 CA ALA 444 21.677 0.633 71.090 1.00 58.15 C
ATOM 2295 CB ALA 444 20.542 1.165 71.938 1.00 58.08 C
ATOM 2296 C ALA 444 21.137 -0.032 69.827 1.00 58.43 C
ATOM 2297 O ALA 444 21.476 -1.214 69.567 1.00 59.04 O
ATOM 2298 OXT ALA 444 20.403 0.663 69.088 1.00 57.70 O
ATOM 2299 CL4 INH 1 32.459 13.081 76.363 1.00 29.94 CL
ATOM 2300 CL2 INH 1 28.833 9.640 74.234 1.00 32.44 CL
ATOM 2301 Cl INH 1 35.318 2.998 74.694 1.00 23.99 C
ATOM 2302 Sl INH 1 31.669 5.656 76.307 1.00 37.70 S
ATOM 2303 C2 INH 1 34.148 3.767 75.007 1.00 27.57 C
ATOM 2304 C3 INH 1 34.210 4.397 76.249 1.00 29.72 C
ATOM 2305 N4 INH 1 35.292 4.281 77.059 1.00 25.29 N
ATOM 2306 C5 INH 1 36.332 3.545 76.687 1.00 25.63 C
ATOM 2307 N6 INH 1 36.410 2.876 75.520 1.00 24.06 N
ATOM 2308 N9 INH 1 37.348 3.491 77.561 1.00 24.62 N
ATOM 2309 ClO INH 1 37.283 4.209 78.829 1.00 25.32 C
ATOM 2310 CIS INH 1 33.189 5.232 76.885 1.00 31.74 C
ATOM 2311 C16 INH 1 33.357 5.759 78.054 1.00 34.78 C
ATOM 2312 C17 INH 1 32.260 6.514 78.516 1.00 37.03 C
ATOM 2313 C18 INH 1 31.188 6.575 77.664 1.00 35.33 C
ATOM 2314 i C22 INH 1 30.056 7.295 78.051 1.00 36.13 C
ATOM 2315 023 INH 1 30.134 7.825 79.155 1.00 39.85 O
ATOM 2316 N24 INH 1 28.942 7.430 77.323 1.00 36.41 N ATOM 2317 C25 INH 1 27.825 8.213 77.858 00 35.49 C
ATOM 2318 C27 INH 1 26.552 7.372 77.965 00 36.43 C
ATOM 2319 C28 INH 1 27.615 9.443 76.988 00 34.49 C
ATOM 2320 C30 INH 1 28.822 10.354 76.796 00 32.51 C
ATOM 2321 C33 INH 1 29.444 10.502 75.571 00 31.00 C
ATOM 2322 C34 INH 1 30.578 11.342 75.388 00 30.98 C
ATOM 2323 C35 INH 1 31.076 12.048 76.513 1.00 31.67 C
ATOM 2324 C36 INH 1 30.461 11.921 77.783 1.00 30.53 C
ATOM 2325 C37 INH 1 29.343 11.077 77.911 00 30.57 C
ATOM 2326 N43 INH 1 26.657 6.687 79.238 00 38.52 N
ATOM 2327 O HOH 1 34.033 8.167 104.871 00 27.48 W O
ATOM 2328 O HOH 2 28.081 -0.376 74.800 00 19.48 W ό
ATOM 2329 O HOH 3 43.080 2.114 87.557 00 25.87 W O
ATOM 2330 O HOH 4 44.469 -18.825 92.634 00 16.02 W O
ATOM 2331 O HOH 5 37.993 -0.894 102.786 1.00 20.05 W O
ATOM 2332 O HOH 6 31.387 -14.406 102.201 1.00 22.73 W O
ATOM 2333 0 HOH 7 26.985 1.477 81.269 1.00 29.25 W O
ATOM 2334 O HOH 8 36.069 -18.297 94.258 1.00 16.70 W O
ATOM 2335 O HOH 9 29.441 -16.818 96.657 1.00 23.71 W O
ATOM 2335 O HOH 10 38.318 -11.642 88.861 1.00 33.26 W O
ATOM 2337 O HOH 11 53.066 17.810 77.941 1.00 30.45 W O
ATOM 2338 O HOH 12 31.425 -10.610 81.865 1.00 19.54 W O
ATOM 2339 O HOH 13 39.303 -14.757 99.834 1.00 31.48 W O
ATOM 2340 O HOH 14 24.749 -16.937 97.814 1.00 25.11 W O
ATOM 2341 O HOH 15 47.355 -8.942 95.368 1.00 40.41 W O
ATOM 2342 O HOH 16 41.328 -3.903 96.161 1.00 24.63 W O
ATOM 2343 O HOH 17 45.343 0.849 99.601 1.00 36.81 W O
ATOM 2344 O HOH 18 17.915 2.893 108.527 1.00 38.85 W O
ATOM 2345 O HOH 19 33.204 -18.332 102.933 1.00 32.96 W O
ATOM 2346 O HOH 20 33'.696 -3.637 70.770 23.17 W O
ATOM 2347 O HOH 21 47.345 -0.584 72.822 38.01 W O
ATOM 2348 O HOH 22 18.565 -12.686 88.642 29.26 W O
ATOM 2349 O HOH 23 42.936 19.222 82.463 '42.05 W O
ATOM 2350 O HOH 24 47.213 -9.152 89.606 39.73 W O
ATOM 2351 O HOH 25 42.762 -1.119 85.336 33.99 W O
ATOM 2352 O HOH 26 27.312 7.916 103.617 31.09 W O
ATOM 2353 O HOH 27 36.834 11.453 98.096 35.19 W O
ATOM 2354 O HOH 28 22.787 -16.430 94.394 39.75 W O
ATOM 2355 O HOH 29 23.113 -13.637 82.958 34.33 W O
ATOM 2356 O HOH 30 29.033 5.760 94.638 19.82 W O
ATOM 2357 O HOH 31 43.536 12.032 62.629 29.33 W O
ATOM 2358 O HOH 32 28.995 2.566 111.464 27.60 W O
ATOM 2359 O HOH 33 54.719 8.666 74.949 35.13 W O
ATOM 2360 O HOH 34 29.416 16.620 110.838 43.90 W O
ATOM 2361 O HOH 35 37.655 5.646 86.657 34.27 W O
ATOM 2362 O HOH 36 33.979 -15.112 100.654 14.57 W O
ATOM 2363 O HOH 37 34.835 11.581 94.233 37.75 W O
ATOM 2364 O HOH 38 33.278 16.442 107.042 39.85 W O
ATOM 2365 O HOH 39 37.021 -10.511 107.115 36.22 W O
ATOM 2366 O HOH 40 46.162 11.240 61.826 31.52 W O
ATOM 2367 O HOH 41 40.669 -12.705 81.771 34.50 W O
ATOM 2368 O HOH 42 44.976 -9.658 81.925 42.07 W O
ATOM 2369 O HOH 43 22.738 -17.412 89.187 33.92 W O
ATOM 2370 O HOH 44 45.522 -14.719 85.411 36.50 W O
ATOM 2371 O HOH 45 56.993 3.854 70.321 40.32 W O
ATOM 2372 O HOH 46 33.209 -15.322 66.919 32.58 W O
ATOM 2373 O HOH 47 46.288 5.592 103.608 51.67 W O
ATOM 2374 O HOH 48 16.384 -2.001 103.600 23.58 W 0
ATOM 2375 O HOH 49 19.958 -10.012 106.809 36.38 W O
ATOM 2376 O HOH 50 38.273 4.874 104.158 32.50 W O
ATOM 2377 O HOH 51 48.122 -13.353 93.571 35.47 W O
ATOM 2378 O HOH 52 38.358 -7.718 111.136 25.57 W O
ATOM 2379 O HOH 53 23.874 -18.557 91.650 1.00 41.87 W O
ATOM 2380 O HOH 54 16.838 -3.706 82.426 36.51 W O
ATOM 2381 O HOH 55 44.495 -7.643 88.563 30.18 W O
ATOM 2382 O HOH 56 22.133 -17.662 97.061 25.95 W O
ATOM 2383 O HOH 57 9.060 12.078 85.245 39.91 W O
ATOM 2384 O HOH 58 47.865 -2.424 66.608 44.03 W O
ATOM 2385 O HOH 59 41.291 -8.309 62.947 38.50 W O
ATOM 238S O HOH 60 15.665 1.172 101.644 30.88 W O
ATOM 2387 O HOH 61 29.225 18.556 105.851 46.64 W O
ATOM 2388 O HOH 62 24.876 5.977 93.833 33.45 W O
ATOM 2389 O HOH 63 45.275 -2.177 93.688 1.00 41.77 W O ATOM 2390 O HOH 64 17.055 -12.807 103.028 1.00 32.83 W O
ATOM 2391 O HOH 65 30.771 -10.179 108.712 1.00 33.96 W O
ATOM 2392 O HOH 66. 8.846 -13.411 102.337 1.00 37.47 W O
ATOM 2393 O HOH 67 24.555 8.869 96.575 1.00 41.24 W O
ATOM 2394 O HOH 68 25.937 20.495 73.636 1.00 39.88 W O
ATOM 2395 O HOH 69 29.507 -21.519 99.441 1.00 38.67 W O
ATOM 2396 O HOH 70 11.642 -6.727 88.789 1.00 45.88 W O
ATOM 2397 O HOH 71 40.732 -5.816 81.387 1.00 44.81 W O
END
[0087] The Akt3 binding pocket for N-[(l S)-2-amino-l-(2,4- dich.loroben2yl)etliyl]-5-[2-(methylammo)pyrimidin-4-yl]tliiophene-2-carboxamide corresponding to a 12, 9, an 6 angstrom sphere about the compound is shown in Tables 6, 7, and 8 respectively.
Table 6. Akt 3 binding pocket for N-[(lS)-2-amino-l-(2,4-dichlorobenzyl)ethyI]- 5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide based on an approximate 12 Angstrom sphere.
Figure imgf000204_0001
Table 7. Akt 3 binding pocket for N-[(lS)-2-amino-l-(2,4-dichlorobenzyl)ethyl]- 5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide based on an approximate 9 Angstrom sphere.
Figure imgf000204_0002
6569
Figure imgf000205_0001
Table 8. Akt 3 binding pocket for N-[(lS)-2^amino-l-(2,4-dichlorobenzyl)ethyl]- 5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide based on an approximate 6 Angstrom sphere.
LEU 15 GLY 17 LYS 19 GLY 21 PHE 19
GLY 16 LYS 15 VAL 13 ALA 8 LYS 11
ILE 11 LEU 13 THR 8 MET 6 GLU 5
TYR 7 VAL 10 ASN 12 GLU 22 PHE 15
GLY 17 ALA 20
[0088] The Akt3 binding pocket for N-[6-(ammomethyl)-4-chloro-l,3- benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxainide corresponding to a 12, 9, and 6 Angstrom sphere about the compound is shown in Tables 9, 10, and 11 respectively.
Table 9. Akt 3 binding pocket for N-[6-(aminomethyl)-4-chloro-l,3- benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide based on an approximate 12 Angstrom sphere.
Figure imgf000205_0002
Figure imgf000206_0001
Table 10. Akt 3 binding pocket for N-[6-(aminomethyl)-4-chloro-l,3- benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide based on an approximate 9 Angstrom sphere.
Figure imgf000206_0002
Table 11. Akt 3 binding pocket for N-[6-(aminomethyl)-4-chloro-l,3- benzothiazol-2-yl]-5-(2-aminopyrimidin-4~yl)thiophene-2-carboxamide based on an approximate 6 Angstrom sphere.
Figure imgf000206_0003
Akt3 / Compound Structural Representation.
[0089] As noted above, in one aspect, the invention provides a method for identifying possible therapeutic compounds in the treatment of various disease conditions mediated by Akt3 activity. The method involves the use of a three- dimensional structural representation of the Akt3 / compound complex. [0090] Variants of the atomic coordinates in Tables 1-5 can also be used for the invention such as variants in which the RMS (root mean square) deviation of the x, y, and z coordinates for all heavy (i.e., not hydrogen) atoms are less than about 2.5A, for example, less than about 2A, preferably less than about 1 A, more preferably less than about 0.5A, or most preferably less than about 0.1 A). Coordinate transformations that retain the three-dimensional spatial relationships of atoms can also be used to give suitable variants.
Identification of Akt3 Compounds
[0091] The invention also provides a method for testing and identifying compounds that can interact with Akt3. These compounds are known compounds, are based on known compounds, or are designed de novo. Suitable compounds include the lH-pyrimidino[5,4-e][l,2,4]triazine-5,7-dione derivatives disclosed in WO 2004/007498 and in WO 2004/007499, azepane derivatives disclosed in WO 03/076429, indazole derivatives disclosed in WO 03/064397, pyrroles disclosed in WO 03/091246, isoxazoles disclosed in WO 02/22610, as well as the pyrazoles disclosed in WO 01/56993, WO 01/57022, and WO 02/50065. Additional compounds include the kinase inhibitors disclosed in WO 03/051366 and WO 04/016597.
[0092] The compounds can be useful pharmaceuticals themselves, or can be prototypes that can be used for further pharmaceutical refinement (i.e., lead compounds) in order to improve binding affinity or other pharmacologically important features (e.g., bio-availability, toxicology, metabolism, pharmacokinetics).
[0093] Accordingly, in another aspect, the invention provides (1) a compound identified using the method of the invention; (2) a compound identified using the method of the invention for use as a pharmaceutical; (3) the use of a compound identified using the method of the invention in the manufacture of a medicament for mediating Akt3 activity; and (4) a method of treating a patient afflicted with a condition mediated by Akt3 activity that includes administering an amount of a compound identified using the method of the invention that is effective (to mediate Akt3 activity.
[0094] These compounds preferably interact with Akt3 with a binding constraint in the micromolar or, more preferably, nanomolar range or stronger.
[0095] As well as being useful compounds individually, compounds identified by the structure-based design techniques can also be used to suggest libraries of compounds for traditional in vitro or in vivo screening methods. Important pharmaceutical motifs in the compounds can be identified and mimicked in compound libraries (e.g., combinatorial libraries) for screening for Akt3-binding activity.
[0096] The structural information obtained from the crystallographic data can be used to develop a compound profile useful for the rational design of compounds for mediating Akt3 activity.
[0097] The compound profile can be primarily based on a shape interaction between the compound and the protein compound binding site. The evaluation of the shape interaction can include consideration of the compound's conformational properties, ranking compounds based on their ability to achieve low energy conformations compatible with the compound binding site. The shape interaction can also seek to maximize enthalpic interactions between the compound and the binding site.
[0098] The process of developing a compound profile can vary widely. For example, the profile can be developed by visual inspection of active site structures by experts. Such an inspection can include the consideration of the binding site and compound structures and compound database searching. The development of the profile can also consider biological data and structure activity relationships (SAR) as well the consideration of known compound binding interaction with other similar proteins. [0099] The compound profile is developed by considering compound binding interactions including primary and secondary interactions and results in defining the pharmacophore. The term "pharmacophore" refers to a collection of chemical features and three-dimensional constraints that represent specific characteristics responsible for a compound's activity. The pharmacophore includes surface- accessible features, hydrogen bond donors and acceptors, charged/ionizable groups, and/or hydrophobic patches, among other features.
[0100] In addition to the process for compound profile development noted above, other structure-based drug design techniques can be applied to the structural representation of the Akt3 in order to identify compounds that interact with Akt3 to mediate Akt3 activity. A variety of suitable techniques are available to one of ordinary skill in the art.
[0101] Software packages for implementing molecular modeling techniques for use in structure-based drug design include SYBYL (available from Tripos Inc., http://www/tripos.com); AMBER (available from Oxford Molecular, http://www/oxmol.co.uk/); CERIUS^ (available from Molecular Simulations Inc., http://www/msi.com/); INSIGHT II (available from Molecular Simulations Inc., http://www/msi.com/); CATALYST (available from Molecular Simulations Inc., http://www/msi.com/); QUANTA (available from Molecular Simulations Inc., http://www/msi.com/); HYPERCHEM (available from Hypercube Inc., httρ://www/hyρer.com/); FIRST DISCOVERY (available from Schrodinger Inc., http://www/schrodinger.com), MOE (available from Chemical Computing Group, http://www/chemcomp.com), and CHEMSITE (available from Pyramid Learning, http://www/chemsite.org/), among others.
[0102] The modeling software can be used to determine Akt3 binding surfaces and to reveal features such as van der Waals contacts, electrostatic interactions, and/or hydrogen bonding opportunities. These binding surfaces can be used to model docking of compounds with Akt3, to arrive at pharmacophore hypotheses, and to design possible therapeutic compounds de novo. Akt3 Compound Virtual Screening
[0103] The three-dimensional structure protein, and the structure of the protein's active site in particular, allows for the determination of the fit of compounds into the active site. Utilizing a fast docking program, individual compounds from, for example, a compound database, can be evaluated for active site binding. The fit of a particular compound can be evaluated and scored. Setting a score threshold can then provide a family of compounds as a solution to the virtual screen.
[0104] At the first level, the virtual screen takes into account the three- dimensional structure of the apoprotein's active site. At the second level, the virtual screen considers the compound profile and can utilize information obtained from the determination of the structure of protein with bound compound. A virtual screen is possible even if there is no structural information on a bound compound.
[0105] Information gained from the virtual screen can be considered to further develop the compound profile. Alternatively, where the results of the virtual screen indicate a promising compound, the compound can be obtained and screened for the relevant biological activity.
Docking
[0106] Docking refers to a process in which two or more molecules are aligned based on energy considerations. Docking aligns the three-dimensional structures of two or more molecules to predict the conformation of a complex formed from the molecules (see, e.g., Blaney & Dixon (1993) Perspectives in Drug Discovery and Design 1:301). hi the practice of the present invention molecules are docked with the Akt3 structure to assess their ability to interact with Akt3.
[0107] Docking can be accomplished by either geometric matching of the compound and its receptor or by minimizing the energy of interaction. Various docking and scoring methodologies maybe used (see Brooijmans, N.; Kuntz, ID (2003) Molecular recognition and docking algorithims. Annu. Rev. Biophys. Biomol. Struct, 32: 335-373; Gohlke, H; Klebe, G. (2002) Approaches to the description and prediction of the binding affinity of small molecule ligands to macroniolecular receptors (2002) Angew. Chem. Int. Ed. Engl, 41:2644-2676; and Taylor, R.D.; Jewsbury, P. J.; Essex, J. W. (2002) A review of protein small molecule docking methods, J Comput. Aided MoL Des., 16:151-166).
[0108] Suitable docking algorithms include DOCK (Kuntz et al. (1982) J. MoI. Biol. 161:269-288, available from UCSF), the prototypical program for structure-based drug design; AUTODOCK (Goodsell & Olson (1990) Proteins: Structure, Function and Genetics 8:195-202 and available from Oxford Molecular, http://www/oxmol.co.uk/), which docks compounds in a flexible manner to receptors using grid-based Monte Carlo simulated annealing. The flexible nature of the AUTODOCK procedure helps to avoid bias (e.g., in orientation and conformation of the compound in the active site) introduced by the user searcher (Meyer et al. (1995) Persp. Drug Disc. 3:168-95) because, while the starting conformation in a rigid docking is normally biased towards a minimum energy conformation of the compound, the binding conformation may be of relatively high conformational energy (Nicklaus et al. (1995) Bioorganic & Medicinal Chemistry 3:411).
[0109] Other suitable docking algorithms include MOE DOCK (available from Chemical Computing Group Inc., http://www/chemcomρ.com), in which a simulated annealing search algorithm is used to flexibly dock compounds and a grid-based energy evaluation is used to score docked conformations; FLExX (available from Tripos Inc., http://www/tripos.com), which docks conformationally flexible compounds into a binding site using an incremental construction algorithm that builds the compound in the site, and scores docked conformations based on the strength of compound-receptor interactions; GOLD (Jones et al. (1997) J. MoI. Biol. 267:727- 748), a genetic algorithm for flexible compound docking, with full compound and partial protein flexibility, and in which energy functions are partly based on conformation and non-bonded contact information; AFFINITY (available from Molecular Simulations Inc., http://www/msi.com/)5 which uses a two step process to dock compounds: first, initial placements of the compound within the receptor are made using a Monte Carlo-type procedure to search both conformational and Cartesian space; and second, a simulated annealing phase optimizes the location of each compound placement, during this phase, AFFINITY holds the "bulk" of the receptor (atoms not in the binding site) rigid, while the binding site atoms and compound atoms are movable; C^ CompoundFit (available from Molecular Simulations Inc., http://www/msi.com/), which uses the energy of the compound- receptor complex to automatically find best binding modes and stochastic conformation search techniques, with the best results from the conformational sampling retained. A grid method is used to evaluate non-bonded interactions between the rigid receptor and the flexible compound atoms. DOCKIT (available from Metaphorics LLC) uses distance geometry for fast flexible compound docking. GLIDE (available from Schrodinger Inc.) uses a pre-computed energy grid and an efficiently pruned systematic search for flexible docking.
[0110] Preferably, the docking algorithm is used in a high-throughput mode, in which members of large structural libraries of potential compounds are screened against the receptor structure (Martin (1992) J. Med. Chem. 35:2145-54).
[0111] Suitable structural libraries include the ACD (Available Chemical Directory, form MDL Inc.), AsInEx, Bionet, ComGenex, the Derwent World Drug Index (WDI), the Contact Service Company database, LaboTest, ChemBridge Express Pick, ChemStar, BioByteMasterFile, Orion, SALOR, TRIAD, ILIAD, the National Cancer Institute database (NCl), and the Aldrich, Fluka, Sigma, and Maybridge catalogs. These are commercially available (e.g., the HTS Chemicals collection from Oxford Molecular, or the LeadQuest™ files from Tripos).
de novo Compound Design.
[0112] The binding surface or pharmacophore of the Akt3 / compound complex can be used to map favorable interaction positions for functional groups (e.g., protons, hydroxy! groups, amine groups, acidic groups, hydrophobic groups and/or divalent cations) or small molecule fragments. Compounds can then be designed de novo in which the relevant functional groups are located in the correct spatial relationship to interact with Akt3. [0113] Once functional groups or small molecule fragments which can interact with specific sites in the binding surface of Akt3 have been identified, they can be linked in a single compound using either bridging fragments with the correct size and geometry or frameworks which can support the functional groups at favorable orientations, thereby providing a compound according to the invention. While linking of functional groups in this way can be done manually, perhaps with the help of software such as QUANTA or SYBYL, automated or semi-automated de novo design approaches can also be used.
[0114] Suitable de novo design software includes MCDLNG (Gehlhaar et al. (1995) J. Med. Chem. 38:466-72), which fills a receptor binding site with a close- packed array of generic atoms and uses a Monte Carlo procedure to randomly vary atom types, positions, bonding arrangements and other properties; MCSS/HOOK (Caflish et al. (1993) J. Med. Chem. 36:2142-67; Eisen et al. (1994) Proteins: Str. Funct. Genet. 19:199-221; available from Molecular Simulations Inc., http://www/msi.com), which links multiple functional groups with molecular templates taken from a database; LUDI (Bohm (1992) J. Comp. Aided Molec. Design 6:61-78, available from Molecular Simulations Inc., http://www/msi.com), which computes the points of interaction that would ideally be fulfilled by a compound, places fragments in the binding site based on their ability to interact with the receptor, and then connects them to produce a compound; GROW (Moon and Howe (1991) Proteins: Str. Funct. Genet. 11:314-328), which starts with an initial "seed" fragment (placed manually or automatically) and grows the compound outwards; SPROUT (available from http://chem.leeds.ac.uMCAMS/SPROUT.html), which includes molecules to identify favorable hydrogen bonding and hydrophobic regions within a binding pocket (HIPPO module), selects functional groups and positions them at target sites to form starting fragments for structure generation (EleFanT), generates skeletons that satisfy the steric constraints of the binding pocket by growing spacer fragments onto the start fragments and then connecting the resulting part skeletons (SPIDeR), substitutes hetero atoms into the skeletons to generate molecules with the electrostatic properties that are complementary to those of the receptor site (MARABOU), and the solutions can be clustered and scored using the ALLigaTOR module; LEAPFROG (available from Tripos Inc., http://www/tripos.com), which evaluates compounds by making small stepwise structural changes and rapidly evaluating the binding energy of the new compound, keeps or discards changes based on the altered binding energy, and evolves structures to increase the interaction energy with the receptor; GROUPBUILD (Rorstein et al. (1993) J. Med. Chem. 36:1700), which uses a library of common organic templates and a complete empirical force field description of the non-bonding interactions between a compound and receptor to construct compounds that have chemically reasonable structure and have steric and electrostatic properties complimentary to the receptor binding site; CAVEAT (Lauri and Bartlett (1994) Comp. Aided MoI. Design 8:51-66), which designs linking units to constrain acyclic molecules; and RASSE (Lai (1996) J. Chem. Inf. Comput. Sci. 36:1187-1194).
Akt3 Structural Representation Storage Medium.
[0115] The atomic coordinates of the Akt3 / compound complex can be stored on a medium for subsequent use with a computational device, such as a computer (e.g., supercomputer, mainframe, minicomputer, or microprocessor). Typically, the coordinates are stored on a medium useful to hold large amounts of data, such as magnetic or optical media (e.g., floppy disks, hard disks, compact disks, magneto- optical media ("floptical" disks, or magnetic tape) or electronic media (e.g., random- access memory (RAM), or read-only memory (ROM). The storage medium can be local to the computer, or can be remote (e.g., a networked storage medium, including the Internet). The choice of computer, storage medium, networking, and other devices or techniques will be familiar to those of skill in the structural/computational chemistry arts.
[0116] From the foregoing description, various modifications and changes in the composition and method will occur to those skilled in the art. All such modifications coming within the scope of the appended claims are intended to be included therein.

Claims

CLAIMS What is claimed is:
1. An Akt3 polypeptide crystal wherein said crystal is resolvable using X- ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination of the Akt3 polypeptide.
2. The crystal of Claim 1 wherein said Akt3 polypeptide has at least a 90% amino acid sequence identity to residues 138 to 479 of SEQ ID NO:1 or SEQ ID NO:2.
3. The crystal of Claim 1 wherein at least one of amino acid residues 305 or 472 of the Akt3 polypeptide is an aspartic amino acid.
4. The crystal of Claim 1 having the atomic coordinates set forth in Tables 1 or 2.
5. A co-crystal of an Akt3 polypeptide complexed to an Akt3 binding compound wherein said co-crystal is resolvable using X-ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination of the Akt3 complex.
6. The co-crystal of Claim 5 having the atomic coordinates set forth in Tables 3, 4, or 5.
7. The co-crystal of Claim 5 wherein said Akt3 binding compound is N- [6-(aminomethyl)-4-chloro-l,3-benzothiazol-2-yl]-5-(2-aminopyrimidin-4- yl)thiophene-2-carboxamide or N-[(lS)-2-amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2~ (methylamino)pyrimidin-4-yl]thiophene-2-carboxamide.
8. A method for crystallizing an Akt3 polypeptide comprising: (a) providing an Akt3 polypeptide and
(b) crystallizing the Akt3 polypeptide from a solution to provide a crystal, wherein the crystal is resolvable using X-ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination.
9. A method for crystallizing an Akt3 polypeptide complexed to a compound, comprising:
(a) providing an Akt3 polypeptide;
(b) contacting the Akt3 polypeptide with the compound; and
(c) crystallizing the Akt3 polypeptide and compound from a solution to provide a crystallized complex, wherein the crystallized complex is resolvable using X-ray crystallography to obtain X-ray patterns suitable for three dimensional structural determination.
10. The method of Claims 8 or 9 wherein the Akt3 polypeptide comprises amino acid residues 138-479 of SEQ ID NO: 1.
11. The method of Claims 8 or 9 wherein the Akt3 polypeptide comprises amino acid residues 138-479 of SEQ ID NO: 2.
12. A method for evaluating the ability of a compound to associate with an Akt3 polypeptide, the method comprising the steps of:
(a) providing a three dimensional Akt3 structure using at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5 wherein the atomic coordinate root mean square deviation is less than 3.0 A;
(b) providing a three dimensional compound structure of said compound;
(c) employing a fitting process to dock or superimpose said compound structure onto said three dimensional Akt3 structure; and
(d) analyzing the results of said fitting process.
13. A method for identifying a compound capable of modifying Akt3 activity, the method comprising the steps of: (a) providing a three dimensional AM3 structure using at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5 wherein the atomic coordinate root mean square deviation is less than 3.0 A;
(b) providing a three dimensional compound structure of said compound;
. (c) employing a fitting process to dock or superimpose said three dimensional compound structure onto said three dimensional Akt3 structure;
(d) analyzing the results of said fitting process;
(e) synthesizing the compound; and
(f) contacting the compound with an Akt3 polypeptide to determine the ability of the compound to modify Akt3 activity.
14. The method of Claims 12 or 13 wherein said root mean square deviation is less than 2.5A.
15. The method of Claims 12 or 13 wherein said root mean square deviation is less than 2.0A.
16. The method of Claims 12 or 13 wherein said three dimensional Akt3 structure comprises the amino acids set forth in Tables 6, 7, 8, 9, 10, or 11.
17. The method of Claims 12 or 13 wherein said three dimensional compound structure associates with one or more amino acid set forth in Tables 6, 7, 8, 9, 10, or 11.
18. The method of Claims 12 or 13 wherein said compound structure is a known kinase inhibitor or portion thereof.
19. The method of Claims 12 or 13 wherein said compound structure or portion thereof is N-[(lS).-2-amino-l-(2,4-dichlorobenzyl)ethyl]-5-[2- (methylamino)pyrimidin-4-yl]thiophene-2-carboxamide or N-[6-(aminomethyl)-4- chloro-l,3-benzothiazol-2-yl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide.
20. The method of Claims 12 or 13 wherein said compound structure is selected from a database.
21. The method of Claims 12 or 13 wherein said compound structure is designed de novo.
22. The method of Claim 13 wherein said compound is a competitive ATP inhibitor.
23. A computer for producing a three-dimensional representation of a molecule or molecular complex, wherein said computer comprises:
(a) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5;
(b) a working memory for storing instructions for processing said machine-readable data;
(c) a central-processing unit coupled to said working memory and to said machine-readable data storage medium for processing said machine readable data into said three-dimensional representation; and
(d) a means for displaying said three-dimensional representation.
24. A computer for determining at least a portion of the atomic coordinates corresponding to an X-ray diffraction pattern of a molecule or molecular complex, wherein said computer comprises:
(a) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises at least a portion of the atomic coordinates set forth in Tables 1, 2, 3, 4, or 5;
(b) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises an X-ray diffraction pattern of said molecule or molecular complex;
(c) a working memory for storing instructions for processing said machine-readable data of (a) and (b);
(d) a central-processing unit coupled to said working memory and to said machine-readable data storage medium of (a) and (b) for performing a Fourier transform of the machine readable data of (a) and for processing said machine readable data of (b) into structure coordinates; and
(e) a display coupled to said central-processing unit for displaying said structure coordinates of said molecule or molecular complex.
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Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2000037613A2 (en) * 1998-12-22 2000-06-29 Janssen Pharmaceutica N.V. Human akt-3
WO2003016517A2 (en) * 2001-08-14 2003-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Kinase crystal structures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037613A2 (en) * 1998-12-22 2000-06-29 Janssen Pharmaceutica N.V. Human akt-3
WO2003016517A2 (en) * 2001-08-14 2003-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Kinase crystal structures

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Title
GASSEL MICHAEL ET AL: "Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT).", JOURNAL OF MOLECULAR BIOLOGY, vol. 329, no. 5, 20 June 2003 (2003-06-20), pages 1021 - 1034, XP004457727, ISSN: 0022-2836 *
HARRIS THOMAS K: "PDK1 and PKB/Akt: Ideal targets for development of new strategies to structure-based drug design.", IUBMB LIFE, vol. 55, no. 3, March 2003 (2003-03-01), pages 117 - 126, XP009041386, ISSN: 1521-6543 *
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