WO2006021655A3 - Oxopiperidine derivatives, preparation and therapeutic use thereof - Google Patents

Oxopiperidine derivatives, preparation and therapeutic use thereof Download PDF

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Publication number
WO2006021655A3
WO2006021655A3 PCT/FR2005/001854 FR2005001854W WO2006021655A3 WO 2006021655 A3 WO2006021655 A3 WO 2006021655A3 FR 2005001854 W FR2005001854 W FR 2005001854W WO 2006021655 A3 WO2006021655 A3 WO 2006021655A3
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WO
WIPO (PCT)
Prior art keywords
alkyl
groups
therapeutic use
derivatives
cycloalkyl
Prior art date
Application number
PCT/FR2005/001854
Other languages
French (fr)
Other versions
WO2006021655A8 (en
WO2006021655A2 (en
Inventor
Alain Braun
Gilles Courtemanche
Olivier Crespin
Eykmar Fett
Cecile Pascal
Original Assignee
Sanofis Aventis
Alain Braun
Gilles Courtemanche
Olivier Crespin
Eykmar Fett
Cecile Pascal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34947722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006021655(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to MX2007001139A priority Critical patent/MX2007001139A/en
Priority to BRPI0512680-0A priority patent/BRPI0512680A/en
Priority to DK05790990.5T priority patent/DK1773796T3/en
Priority to JP2007523108A priority patent/JP4871866B2/en
Priority to DE602005019743T priority patent/DE602005019743D1/en
Priority to EP05790990A priority patent/EP1773796B1/en
Priority to AT05790990T priority patent/ATE459608T1/en
Priority to PL05790990T priority patent/PL1773796T3/en
Priority to SI200531010T priority patent/SI1773796T1/en
Priority to AU2005276353A priority patent/AU2005276353C1/en
Application filed by Sanofis Aventis, Alain Braun, Gilles Courtemanche, Olivier Crespin, Eykmar Fett, Cecile Pascal filed Critical Sanofis Aventis
Priority to CA002577177A priority patent/CA2577177A1/en
Publication of WO2006021655A2 publication Critical patent/WO2006021655A2/en
Publication of WO2006021655A3 publication Critical patent/WO2006021655A3/en
Priority to IL180770A priority patent/IL180770A/en
Priority to US11/626,970 priority patent/US20070149562A1/en
Publication of WO2006021655A8 publication Critical patent/WO2006021655A8/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Abstract

The invention concerns oxopiperidine derivatives of general formula (I) wherein: n = 1; Ra, Ra′, Rb et Rb′ represent hydrogen atoms or alkyl or cycloalkyl groups, or Rb and Rb′ together form a carbon bridge; R1 represents an alkyl or cycloalkyl group; R2 represents a heteroaryl group; R3 represents 1 to 3 groups selected among halogen atoms and alkyl, cycloalkyl, -OR, -NRR', -CO-NRR', -NR-CO-R', -NR-CO-NRR1, -NR-COOR', -NO2, -CN and COOR groups; R5 represents a hydrogen atom or an alkyl group; R4 is selected among the groups of formulae (a), (b) and (c), wherein p = 0, 1, 2 or 3, m = 0, 1 or 2, and X represents a -C(R6)(R7)- or -N(R10)- member. The invention also concerns a method for preparing said derivatives and their therapeutic use.
PCT/FR2005/001854 2004-07-29 2005-07-20 Oxopiperidine derivatives, preparation and therapeutic use thereof WO2006021655A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA002577177A CA2577177A1 (en) 2004-07-29 2005-07-20 Oxopiperidine derivatives, preparation and therapeutic use thereof
AU2005276353A AU2005276353C1 (en) 2004-07-29 2005-07-20 Oxopiperidine derivatives, preparation and therapeutic use thereof
SI200531010T SI1773796T1 (en) 2004-07-29 2005-07-20 Oxopiperidine derivatives, preparation and therapeutic use thereof
JP2007523108A JP4871866B2 (en) 2004-07-29 2005-07-20 Oxopiperidine derivatives, their preparation and therapeutic use
BRPI0512680-0A BRPI0512680A (en) 2004-07-29 2005-07-20 oxopiperidine derivatives, their preparation and their application in
EP05790990A EP1773796B1 (en) 2004-07-29 2005-07-20 Oxopiperidine derivatives, preparation and therapeutic use thereof
AT05790990T ATE459608T1 (en) 2004-07-29 2005-07-20 OXOPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE
MX2007001139A MX2007001139A (en) 2004-07-29 2005-07-20 Oxopiperidine derivatives, preparation and therapeutic use thereof.
DK05790990.5T DK1773796T3 (en) 2004-07-29 2005-07-20 Oxopiperidine derivatives, their preparation and their therapeutic use
DE602005019743T DE602005019743D1 (en) 2004-07-29 2005-07-20 OXOPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USES
PL05790990T PL1773796T3 (en) 2004-07-29 2005-07-20 Oxopiperidine derivatives, preparation and therapeutic use thereof
IL180770A IL180770A (en) 2004-07-29 2007-01-17 Oxopiperidine derivatives, their preparation and therapeutic use thereof
US11/626,970 US20070149562A1 (en) 2004-07-29 2007-01-25 Oxopiperidine derivatives, preparation and therapeutic use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0408369 2004-07-29
FR0408369A FR2873690B1 (en) 2004-07-29 2004-07-29 OXOPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/626,970 Continuation US20070149562A1 (en) 2004-07-29 2007-01-25 Oxopiperidine derivatives, preparation and therapeutic use thereof

Publications (3)

Publication Number Publication Date
WO2006021655A2 WO2006021655A2 (en) 2006-03-02
WO2006021655A3 true WO2006021655A3 (en) 2006-04-20
WO2006021655A8 WO2006021655A8 (en) 2007-05-24

Family

ID=34947722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/001854 WO2006021655A2 (en) 2004-07-29 2005-07-20 Oxopiperidine derivatives, preparation and therapeutic use thereof

Country Status (25)

Country Link
US (1) US20070149562A1 (en)
EP (1) EP1773796B1 (en)
JP (1) JP4871866B2 (en)
KR (1) KR20070047802A (en)
CN (1) CN101010309A (en)
AR (1) AR054208A1 (en)
AT (1) ATE459608T1 (en)
AU (1) AU2005276353C1 (en)
BR (1) BRPI0512680A (en)
CA (1) CA2577177A1 (en)
CY (1) CY1110124T1 (en)
DE (1) DE602005019743D1 (en)
DK (1) DK1773796T3 (en)
ES (1) ES2341722T3 (en)
FR (1) FR2873690B1 (en)
IL (1) IL180770A (en)
MX (1) MX2007001139A (en)
PE (1) PE20060563A1 (en)
PL (1) PL1773796T3 (en)
PT (1) PT1773796E (en)
RU (1) RU2376298C2 (en)
SI (1) SI1773796T1 (en)
TW (1) TW200609217A (en)
UY (1) UY29036A1 (en)
WO (1) WO2006021655A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873691B1 (en) * 2004-07-29 2006-10-06 Sanofi Synthelabo AMINO-PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CA2666193A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
EP2020405A1 (en) * 2007-07-30 2009-02-04 Santhera Pharmaceuticals (Schweiz) AG Substituted aryl or heteroarylpiperidine derivatives as melanocortin-4 receptor modulators
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
EP2310372B1 (en) 2008-07-09 2012-05-23 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2683701B1 (en) 2011-03-08 2014-12-24 Sanofi Oxathiazine derivatives substituted with benzyl or heteromethylene groups, method for their preparation, their usage as medicament, medicament containing same and its use
EP2683704B1 (en) 2011-03-08 2014-12-17 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8809325B2 (en) 2011-03-08 2014-08-19 Sanofi Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
EP2683705B1 (en) 2011-03-08 2015-04-22 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US9744171B2 (en) 2012-03-06 2017-08-29 Vanderbilt University Positive allosteric modulators for melanocortin receptors

Citations (6)

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WO2000074679A1 (en) * 1999-06-04 2000-12-14 Merck & Co., Inc. Substituted piperidines as melanocortin-4 receptor agonists
WO2001070708A1 (en) * 2000-03-23 2001-09-27 Merck & Co., Inc. Substituted piperidines as melanocortin receptor agonists
WO2002015909A1 (en) * 2000-08-23 2002-02-28 Merck & Co., Inc. Substituted piperidines as melanocortin receptor agonists
WO2002079146A2 (en) * 2001-03-02 2002-10-10 Bristol-Myers Squibb Company Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same
WO2003007949A1 (en) * 2001-07-18 2003-01-30 Merck & Co., Inc. Bridged piperidine derivatives as melanocortin receptor agonists
WO2003092690A1 (en) * 2002-04-30 2003-11-13 The Procter & Gamble Company N-acyl piperidine derivatives for use as melanocortin receptor ligands in the treatment of feeding disorders

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US5968929A (en) * 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
US6977264B2 (en) * 2001-07-25 2005-12-20 Amgen Inc. Substituted piperidines and methods of use
US7049323B2 (en) * 2003-04-25 2006-05-23 Bristol-Myers Squibb Company Amidoheterocycles as modulators of the melanocortin-4 receptor
KR20050045927A (en) * 2003-11-12 2005-05-17 주식회사 엘지생명과학 Melanocortin receptor agonists
FR2873691B1 (en) * 2004-07-29 2006-10-06 Sanofi Synthelabo AMINO-PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2873693B1 (en) * 2004-07-29 2006-09-15 Sanofi Synthelabo AMINO-TROPANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
WO2000074679A1 (en) * 1999-06-04 2000-12-14 Merck & Co., Inc. Substituted piperidines as melanocortin-4 receptor agonists
WO2001070708A1 (en) * 2000-03-23 2001-09-27 Merck & Co., Inc. Substituted piperidines as melanocortin receptor agonists
WO2002015909A1 (en) * 2000-08-23 2002-02-28 Merck & Co., Inc. Substituted piperidines as melanocortin receptor agonists
WO2002079146A2 (en) * 2001-03-02 2002-10-10 Bristol-Myers Squibb Company Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same
WO2003007949A1 (en) * 2001-07-18 2003-01-30 Merck & Co., Inc. Bridged piperidine derivatives as melanocortin receptor agonists
WO2003092690A1 (en) * 2002-04-30 2003-11-13 The Procter & Gamble Company N-acyl piperidine derivatives for use as melanocortin receptor ligands in the treatment of feeding disorders

Also Published As

Publication number Publication date
BRPI0512680A (en) 2008-04-01
AR054208A1 (en) 2007-06-13
IL180770A0 (en) 2007-06-03
MX2007001139A (en) 2007-04-19
AU2005276353C1 (en) 2012-03-29
JP4871866B2 (en) 2012-02-08
ATE459608T1 (en) 2010-03-15
WO2006021655A8 (en) 2007-05-24
CN101010309A (en) 2007-08-01
US20070149562A1 (en) 2007-06-28
SI1773796T1 (en) 2010-07-30
DK1773796T3 (en) 2010-06-21
EP1773796A2 (en) 2007-04-18
EP1773796B1 (en) 2010-03-03
AU2005276353B2 (en) 2011-12-01
CY1110124T1 (en) 2015-01-14
PL1773796T3 (en) 2010-08-31
ES2341722T3 (en) 2010-06-25
PE20060563A1 (en) 2006-07-12
CA2577177A1 (en) 2006-03-02
TW200609217A (en) 2006-03-16
FR2873690A1 (en) 2006-02-03
FR2873690B1 (en) 2006-10-13
RU2376298C2 (en) 2009-12-20
IL180770A (en) 2011-10-31
WO2006021655A2 (en) 2006-03-02
DE602005019743D1 (en) 2010-04-15
PT1773796E (en) 2010-06-01
AU2005276353A1 (en) 2006-03-02
UY29036A1 (en) 2006-02-24
KR20070047802A (en) 2007-05-07
RU2007107374A (en) 2008-09-10
JP2008508240A (en) 2008-03-21

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