WO2006013183A1 - Composition comprising a pulmonary surfactant and a tnf-derived peptide - Google Patents
Composition comprising a pulmonary surfactant and a tnf-derived peptide Download PDFInfo
- Publication number
- WO2006013183A1 WO2006013183A1 PCT/EP2005/053672 EP2005053672W WO2006013183A1 WO 2006013183 A1 WO2006013183 A1 WO 2006013183A1 EP 2005053672 W EP2005053672 W EP 2005053672W WO 2006013183 A1 WO2006013183 A1 WO 2006013183A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical composition
- peptide
- composition according
- pulmonary surfactant
- effective amount
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0082—Lung surfactant, artificial mucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the invention relates to the combination of certain known active compounds for therapeutic purposes.
- the compounds used in the combination according to this invention are known pulmonary surfactants and a known active compound derived from TNF. Their combined use in the sense according to this invention for therapeutic purposes has not yet been described in prior art.
- ARDS Adult Respiratory Distress Syndrome
- ARDS is a descriptive expression which is applied to a large number of acute, diffuse infiltrative pulmonary lesions of differing etiology if they are associated with a severe gas exchange disorder (in particular arterial hypoxemia) [G. R. Bernard et al.: Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination; Intensive Care Medicine, 1994, 20:225-232].
- the expression ARDS is also used for IRDS (Infant Respiratory Distress Syndrome) because of the numerous common clinical and pathological features.
- ARDS a lung surfactant malfunction is caused by the disease of the lung based on differing etiologies.
- Triggering causes for an ALI (Acute Lung Injury) including ARDS can, for example, be (cited in accordance with Harrison's Principles of Internal Medicine 10th Ed. 1983 McGraw-Hill Int. Book Comp.) diffuse pulmonary infections (e.g. due to viruses, bacteria, fungi), aspiration of, for example, gastric juice or in the case of near-drowning, inhalation of toxins or irritants (e.g.
- lung surfactant function is impaired so that the alveolar surfactant layer does not prevent lung atelectasis and does not maintain physiologic lung functions required for oxygenation.
- pulmonary endothelium regulates the exchange of fluid, solutes, macromolecules, and cells between vascular and tissue spaces.
- inflammation abound in ARDS, the endothelial barrier becomes more permissive for exchange leading to interstitial and alveolar edema formation. This process leads to a further impairment of oxygenation.
- the therapy of ARDS mainly consists in the earliest possible application of different forms of ventilation (e.g. raising of the oxygen concentration of the respiratory air) up to extracorporeal mem ⁇ brane oxygenation.
- the specific use of various ventilation techniques has only led to a small lowering of mortality and including the risk of damaging the lungs by ventilation with pressure and high FiO 2 (Fraction of Inspired Oxygen; proportion of oxygen in the respiratory air).
- FiO 2 Fraction of inspired Oxygen; proportion of oxygen in the respiratory air.
- ARDS patients whose lungs have been damaged by ventilation need even higher pressures and higher FiO 2 to obtain an adequate oxygenation of the blood.
- ARDS Because surfactant function is impaired in ARDS, surfactant replacement therapy is thought to im ⁇ prove lung function and oxygenation in ARDS. It has also proven suitable to treat IRDS by introducing pulmonary surfactant preparations into the lungs of the children concerned.
- WO01076619 and WO03033014 describe the use of pulmonary surfactant preparations for the prophylaxis, early treat ⁇ ment or treatment of acute pulmonary diseases such as ARDS, IRDS or ALI.
- Lucas et al. [Lucas R et al. (1994) Science 263: 814] firstly disclosed a new TNF-derived peptide hav ⁇ ing the amino acid sequence CGQRETPEGAEAKPWYC. This peptide has also been subject in the international patent application WO0009149, which describes the use of TNF-derived peptides in the treatment of edema, in particular lung edema.
- the invention relates to pharmaceutical compositions comprising a pulmonary surfactant and a peptide characterized by an amino acid sequence comprising the hexamer TX 1 EX 2 X 3 E, wherein X 1 , X 2 and X 3 can be any natural or unnatural amino acid, its use as a medicament and methods for treating ARDS, IRDS, ALI or lung edema.
- the invention relates in a first aspect to a pharmaceutical composition
- a pharmaceutical composition comprising an ef ⁇ fective amount of a pulmonary surfactant and an effective amount of a peptide characterized by an amino acid sequence comprising the hexamer TX 1 EX 2 X 3 E, wherein X 1 , X 2 and X 3 can be any natural or unnatural amino acid.
- a pharmaceutical composition comprising an effective amount of a pulmonary surfactant and an effective amount of a peptide characterized by an amino acid sequence comprising the hexamer TPEGAE.
- the peptide of the pharmaceutical composition is further charac ⁇ terized by a chain of 7 to 17 or 11-16 or 13-15 contiguous amino acids or a chain of 14 amino acids derived from the region of human TNF- ⁇ from SeMOO to GIu116
- composition comprising an effective amount of a pulmonary surfactant and an effective amount of a peptide characterized by an amino acid sequence comprising QRETPEGAEAKPWY.
- composition comprising an effective amount of a pulmonary surfactant and an effective amount of a peptide characterized by an amino acid sequence comprising CGQRETPEGAEAKPWYC.
- a pharmaceutical composition comprising an effective amount of a pulmonary surfactant and an effective amount of one of the herein before men ⁇ tioned peptides, wherein the peptide is synthetic.
- a pharmaceutical composition comprising an effective amount of a pulmonary surfactant and an effective amount of one of the herein before men ⁇ tioned peptides, wherein the peptide is circularized.
- a pharmaceutical composition comprising an effective amount of a pulmonary surfactant and an effective amount of one of the herein before men ⁇ tioned peptides, wherein the pulmonary surfactant is selected from the group consisting of PORACTANT ALFA, BERACTANT, BOVACTANT, COLFOSCERIL PALMITATE, SURFACTANT-TA, CALFACTANT, PUMACTANT, LUSUPULTIDE and SINAPULTIDE.
- a pharmaceutical composition comprising an effective amount of a pulmonary surfactant and an effective amount of one of the herein before men ⁇ tioned peptides for use as a medicament.
- a pharmaceutical composition in powder form comprising as a fixed combination of (1) an effective amount of a pulmonary surfactant and (2) an effective amount of one of the herein before mentioned peptides, and (3) optionally a pharmaceutically acceptable carrier.
- a pharmaceutical composition in liquid form comprising as a fixed combination of (1 ) an effective amount of a pulmonary surfactant and (2) an effective amount of one of the herein before mentioned peptides, and (3) optionally a pharmaceutically acceptable carrier.
- a pharmaceutical composition for intratra- cheally or intrabronchially instillation comprising as a fixed combination (1 ) an effective amount of a pulmonary surfactant and (2) an effective amount of one of the herein before mentioned peptides, and (3) optionally a pharmaceutically acceptable carrier.
- composition for inhalation comprising as a fixed combination (1) an effective amount of a pulmonary surfactant and (2) an effec ⁇ tive amount of one of the herein before mentioned peptides, and (3) optionally a pharmaceutically acceptable carrier.
- a pharmaceutical composition in liquid form comprising as a free combination (1) an effective amount of a pulmonary surfactant and optionally a pharmaceutically acceptable carrier and (2) an effective amount of one of the herein before mentioned peptides and optionally a pharmaceutically acceptable carrier.
- a pharmaceutical composition in powder form comprising as a free combination (1) an effective amount of a pulmonary surfactant and optionally a pharmaceutically acceptable carrier and (2) an effective amount of one of the herein before mentioned peptides and optionally a pharmaceutically acceptable carrier.
- a pharmaceutical composition for intratra- cheally or intrabronchially instillation comprising as a free combination (1) an effective amount of a pulmonary surfactant and optionally a pharmaceutically acceptable carrier and (2) an effective amount of one of the herein before mentioned peptides and optionally a pharmaceutically acceptable carrier.
- a pharmaceutical composition for inhalation comprising as a free combination (1) an effective amount of a pulmonary surfactant and optionally a pharmaceutically acceptable carrier and (2) an effective amount of one of the herein before mentioned peptides and optionally a pharmaceutically acceptable carrier.
- a pharmaceutical composition comprising an effective amount of a pulmonary surfactant and an effective amount of one of the herein before men ⁇ tioned peptides for use as a medicament.
- a pharmaceutical composition com ⁇ prising an effective amount of a pulmonary surfactant and an effective amount of one of the herein before mentioned peptides for the manufacture of a medicament for the treatment of a disease se ⁇ lected from the group consisting of ALI, IRDS, ARDS and lung edema.
- a pharmaceutical composition com ⁇ prising an effective amount of a pulmonary surfactant and an effective amount of one of the herein before mentioned peptides for the treatment of a disease selected from the group consisting of ARDS, IRDS, ALI and lung edema.
- a method for treating ARDS, IRDS, ALI or lung edema by administering to a patient in need thereof an effective amount of a pharmaceutical composi ⁇ tion pharmaceutical composition comprising an effective amount of a pulmonary surfactant and an effective amount of one of the herein before mentioned peptides.
- a method for treating ARDS, IRDS, ALI or lung edema by simultaneously administering to a patient in need thereof an effective amount of a pharma ⁇ ceutical composition pharmaceutical composition comprising an effective amount of (1) a pulmonary surfactant and (2) a circularized peptide comprising the amino acids CGQRETPEGAEAKPWYC.
- a method for treating ARDS, IRDS, ALI or lung edema by administering in succession, close in time or remote in time, in any order whatever to a pa ⁇ tient in need thereof an effective amount of a pharmaceutical composition pharmaceutical composition comprising an effective amount of (1 ) a pulmonary surfactant and (2) a circularized peptide comprising the amino acids CGQRETPEGAEAKPWYC.
- Subject matter of present invention is a combination comprising a pulmonary surfactant and a TNF- derived peptide and the use of this combination in the treatment of ARDS, IRDS ALI or lung edema.
- the invention thus relates to a pharmaceutical composition comprising an effective amount of a pul ⁇ monary surfactant and an effective amount of a peptide characterized by an amino acid sequence comprising the hexamer TX 1 EX 2 X 3 E, wherein X 1 , X 2 and X 3 can be any natural or unnatural amino acid, and the combined use of these single compounds to treat ARDS, IRDS, ALI or lung edema.
- pulmonary surfactant useful in this invention may be any compound or pulmonary surfactant preparation that is known to have the same surface-active properties as natural pulmonary surfactant; natural pulmonary surfactant reduces, for example, the surface tension in the alveoli.
- a simple and rapid in vitro test with which the surface activity of pulmonary surfactant can be deter ⁇ mined is, for example, the so-called Wilhelmy balance [Goerke, J. Biochim. Biophys. Acta, 344: 241- 261 (1974), King RJ. and Clements J.A., Am. J. Physicol. 223: 715-726 (1972)].
- This method gives information on the pulmonary surfactant quality, measured as the action of a pulmonary surfactant of achieving a surface tension of almost zero mN/m.
- Another measuring device for determining the sur ⁇ face activity of pulmonary surfactant is the pulsating bubble surfactometer [Possmayer F. et al., Prog. Resp.
- the activity of a pulmonary surfactant prepara ⁇ tion can also be determined by means of in vivo tests, for example as described by Hafner et al. [D. Hafner et al.: Effects of rSP-C surfactant on oxygenation and histology in a rat lung lavage model of acute lung injury. Am. J. Respir. Crit. Care Med. 1998, 158: 270-278].
- a group of known pulmonary surfactant preparations and their modifications that may be usefully as pulmonary surfactant employed in the present invention include pulmonary surfactant preparations having the function of natural pulmonary surfactant.
- Preferred pulmonary surfactant preparations are those which, for example, have activity in the tests described above.
- Particularly preferred pulmonary surfactant preparations are those which exhibit increased activity in such a test in comparison with natural, in particular human, pulmonary surfactant.
- these can be compositions which only contain phospholipids, but also compositions which, apart from the phospholipids, inter alia addi ⁇ tionally contain pulmonary surfactant protein.
- Preferred phospholipids according to the invention are dipalmitoylphosphatidylcholine (DPPC), palmi- toyloleylphosphatidylglycerol (POPG) and/or phosphatidylglycerol (PG).
- DPPC dipalmitoylphosphatidylcholine
- POPG palmi- toyloleylphosphatidylglycerol
- PG phosphatidylglycerol
- the phospholipids are mixtures of various phospholipids, in particular mixtures of dipalmitoyl ⁇ phosphatidylcholine (DPPC) and palmitoyloleylphosphatidylglycerol (POPG), preferably in the ratio from 7 to 3 to 3 to 7.
- CUROSURF® (INN: PORACTANT ALFA) (Serono, Pharma GmbH, Unterschlei ⁇ heim), a natural surfactant from homogenized porcine lungs;
- SURVANTA® (INN: BERACTANT) (Abbott GmbH, Wiesbaden), extract of bovine lungs;
- ALVEOFACT® (INN: BOVACTANT) (Boehringer Ingelheim), extract of bovine lungs;
- EXOSURF® (INN: COLFOSCERIL PALMITATE) (Glaxo SmithKline), a synthetic phospholipid containing excipients;
- SURFACTEN® INN: SURFACTANT-TA
- a pulmonary surfactant extracted from bovine lungs INN: SURFACTANT-TA
- INFASURF® (INN: CALFACTANT) (Forest Pharmaceuticals), a surfactant extracted from calf lungs;
- ALEC® (INN: PUMACTANT) (Britannia Pharmaceuticals), an artificial surfactant of DPPC and PG; and
- BLES® BLES Biochemical Inc.
- bovine lipid extract surfactant BLES Biochemical Inc.
- Suitable pulmonary surfactant proteins are both the proteins obtained from natural sources, such as pulmonary lavage or extraction from amniotic fluid, and the proteins prepared by genetic engineering or chemical synthesis.
- the pulmonary surfactant proteins des ⁇ ignated by SP-B (Surfactant Protein-B) and SP-C (Surfactant Protein-C) and their modified derivatives are of interest.
- the amino acid sequences of these pulmonary surfactant proteins, their isolation or preparation by genetic engineering are known (e.g. from WO 8603408, EP 0251449, WO 8904326, WO 8706943, WO 8803170, WO 9100871 , EP 0368823 and EP 0348967).
- SP-C Modified derivatives of the pulmonary surfactant proteins designated by SP-C, which differ from human SP-C by the replacement of a few amino acids, are described, for example, in WO 9118015 and WO 9532992. Particularly to be emphasized in this connection are the recombinant SP-C (rSP-C) derivatives which are disclosed in WO 9532992, in particular those which differ from human SP-C in positions 4 and 5 by the substitution of cysteine by phenylalanine and in position 32 by the substitution of methionine by isoleucine [desig ⁇ nated herein as rSP-C (FF/I) or LUSUPULTIDE (INN) or VENTICUTE®].
- rSP-C recombinant SP-C
- Modified derivatives of pul ⁇ monary surfactant proteins are also understood as meaning those proteins which have a completely originally designed amino acid sequence with respect to their pulmonary surfactant properties, such as are described in EP 0593094 and WO 9222315.
- the polypeptide KL4 (INN: SINAPULTIDE, SURFAXIN®) may be mentioned in this connection.
- the name pulmonary surfactant protein, accord ⁇ ing to the invention also comprises mixtures of different pulmonary surfactant proteins.
- EP 0100910, EP 0110498, EP 0119056, EP 0145005 and EP 0286011 phospholipid compositions with and without pulmonary surfactant proteins are described which are likewise suitable as components of the preparations.
- fatty acids such as palmitic acid may be mentioned.
- the pulmonary surfactant preparations can also contain electrolytes such as calcium, magnesium and/or sodium salts (for example calcium chloride, sodium chloride and/or sodium hydrogencarbonate) in order to establish an advantageous viscosity.
- Preferred pulmo ⁇ nary surfactant preparations according to the invention contain 80 to 95% by weight of phospholipids, 0.5 to 3.0% by weight of pulmonary surfactant proteins, 3 to 15% by weight of fatty acid, preferably palmitic acid, and 0 to 3% by weight of calcium chloride.
- the pulmonary surfactant preparations are prepared by processes known per se and familiar to the person skilled in the art, for example as described in WO 9532992.
- the pulmonary surfactant preparations are preferably lyophilized and in particular spray-dried pulmonary surfactant preparations. Lyophilized preparations are disclosed, for example, in WO 9735882, WO 9100871 and DE 3229179.
- WO 9726863 describes a process for the preparation of powdered pulmonary surfactant preparations by spray drying. According to the invention, preparations prepared in this way are preferred.
- TNF-derived peptides which may be used in a pharmaceutical composition in accordance with present invention are peptides comprising a chain of 7 to 17, preferably a chain of 11 to 16, more preferably a chain of 13 to 15 and most preferably a chain of 14 or 16 contiguous amino acids derived from the region of human TNF- ⁇ from SeMOO to GIu 116 or from the region of mouse TNF- ⁇ from Ser99 to Glu115. These peptides may be used in a combination with a pulmonary surfactant for the manufac ⁇ ture of a medicament for treating ARDS, IRDS, ALI or lung edema.
- peptides of present are those peptides characterized by an amino acid sequence com ⁇ prising the hexamer TX 1 EX 2 XaE, wherein X 1 , X 2 and X 3 can be any natural or unnatural amino acid.
- TNF-derived peptides of present are those peptides, wherein the hexamer has the sequence TPEGAE.
- Particularly preferred is a peptide comprising the amino acids QRETPEGAEAKPWY such as CGQRETPEGAEAKPWYC. This peptide has been described by Lucas et al. [Lucas R et al. (1994) Science 263: 814].
- CGQRETPEGAEAKPWYC may be used in combina ⁇ tion with a pulmonary surfactant either in linear or in circularized form.
- the term "peptide” refers to a polymer of amino acids (aa) derived from the trypanolytic TNF domain having lectin-like affinity as described by Lucas et al. [Lucas R et al. (1994) Science 263: 814]. Moreover, the latter term relates to a polymer of 7, 8, 9, 10, 11 , 12, 13, 14, 15, 16 or 17 contiguous aa derived from the region of human TNF- ⁇ from SeMOO to GIuM 16 or from the region of mouse TNF- ⁇ from Ser99 to GIuM 15.
- peptide more specifically relates to a peptide comprising the hexamer TPEGAE of the latter TNF regions or any peptide comprising the corresponding amino acids T, E and E of the latter hexamer which were shown to be three critical amino acids by Lucas et al. [Lucas R et al. (1994) Sci ⁇ ence 263: 814].
- present invention refers to pharmaceutical compositions comprising a pulmonary surfac ⁇ tant and a TNF-derived peptide as described above wherein said peptide is circularized. More specifi- cally, the present invention refers to pharmaceutical compositions comprising a pulmonary surfactant and a TNF-derived peptide, wherein said peptide is circularized by replacing the NH2- and COOH- terminal amino acids by cysteine so that a disulfide bridge is formed between the latter cysteines.
- the present invention concerns a pharmaceutical composition comprising a pulmonary surfactant and a TNF-derived peptide, wherein said the circularized peptide is CGQRETPEGAEAKPWYC as described by Lucas et al. [Lucas R et al. (1994) Science 263: 814].
- present invention relates to any peptide derived from the latter TNF regions and does not exclude post- translational modifications of the peptides such as glycosylation, acetylation, phosphorylation, modifications with fatty acids and the like. Included within present invention are, for example, peptides containing one or more analogues of an aa (including unnatural aa's), peptides with substituted linkages, mutated versions or natural sequence variations of the peptides, peptides con ⁇ taining disulfide bonds between cysteine residues, as well as other modifications known in the art.
- the peptides of the present invention can be prepared by any method known in the art such as classi ⁇ cal chemical synthesis, as described by Houben-Weyl [Houben-Weyl Methods of Organic Chemistry. Synthesis of Peptides and Peptidomimetics (M. Goodman, A. Felix, L. Moroder, C. Toniolo, Eds), Georg Thieme Verlag, Stuttgart and New York, 2003] or by means of recombinant DNA techniques as described in Molecular Cloning [Molecular Cloning: A Laboratory Manual, by Joseph Sambrook and David Russell, Third Edition, Cold Spring Harbor Laboratory, 2001 , 3 Volumes] and, more specifically, by Lucas et al. [Lucas R et al. (1994) Science 263: 814].
- edema (or oedema) relates to any abnormal excess accumulation of (serous) fluid in con ⁇ nective tissue or in a serous cavity.
- the latter term relates to "pulmonary edema”.
- pulmonary edema is characterized by a shift of liquid from the pulmonary vessels to the interstitial spaces and the alveolar lumen (interstitial or alveolar edema). Based on their genesis, edema may be divided in hydrostatic and permeability edema, with hydrostatic edema having cardiogenic origin (high blood pressure) and permeability edema occurring after alterations which lead to higher permeability of the endothelial and/or epithelial cell layer at the airway/vessel interface in the lung.
- treating pulmonary edema refers to any intervention, therapy, condi ⁇ tion, or alteration that reverses partially or fully the above mentioned mechanisms of liquid-transfer from the pulmonary vessels to the interstitial spaces and the alveolar lumen and reverses both hydro ⁇ static and permeability edema.
- combined use (or “combination”) embraces the administration of a pulmonary surfactant and a peptide of present invention as part of a specific treatment regimen intended to provide a bene ⁇ ficial effect from the co-action of these therapeutic agents.
- Administration of these therapeutic agents in combination typically is carried out over a defined time period (usually minutes, hours, days or weeks depending upon the combination selected).
- “Combined use” generally is not intended to en ⁇ compass the administration of two of these therapeutic agents as part of separate monotherapy regi ⁇ mens that incidentally and arbitrarily result in the combinations of the present invention.
- Combined use or “combination” within the meaning of the present invention is to be understood as meaning that the individual components of the combination can be administered simultaneously (in the form of a combination medicament - "fixed combination") or more or less simultaneously, respectively in succession (from separate pack units - "free combination”; directly in succession or else alterna ⁇ tively at a relatively large time interval) in a manner which is known per se and customary.
- one therapeutic agent could be taken in the morning and one later in the day.
- one therapeutic agent could be taken once daily and the other twice weekly. It is understood, that if individual components are administered directly in succession, the delay in administering the second component should not be such as to lose the beneficial therapeutic effect of the combination.
- present invention covers all combinations of particular and preferred as ⁇ pects of the invention described herein.
- present invention clearly refers to all compounds or preparations mentioned herein as examples of a pulmonary surfactant and to all compounds men ⁇ tioned herein as a peptide and to all possible consequential combinations.
- combinations which may be mentioned as preferred examples of a combination of a pulmonary surfactant and a peptide are a peptide characterized by an amino acid sequence comprising the hexamer TX 1 EX 2 X 3 E, wherein X 1 , X 2 and X 3 can be any natural or unnatural amino acid, and LUSUPULTIDE, a peptide characterized by an amino acid sequence comprising the hexamer TPEGAE and LUSUPULTIDE, a peptide comprising the amino acids QRETPEGAEAKPWY and LUSUPULTIDE, a peptide comprising the amino acids CQRETPEGAEAKPWYC and LUSUPULTIDE, a circularized peptide comprising the amino acids CQRETPEGAEAKPWYC and LUSUPULTIDE, a peptide characterized by an amino acid sequence comprising the hexamer TX 1 EX 2 X 3 E, wherein X 1 , X 2 and X 3
- CALFACTANT a peptide characterized by an amino acid sequence comprising the hexamer TX 1 EX 2 X 3 E, wherein X 1 , X 2 and X 3 can be any natural or unnatural amino acid
- PUMACTANT a peptide characterized by an amino acid sequence comprising the hexamer TPEGAE and
- PUMACTANT a peptide comprising the amino acids QRETPEGAEAKPWY and PUMACTANT, a peptide comprising the amino acids CQRETPEGAEAKPWYC and PUMACTANT, a circularized peptide comprising the amino acids CQRETPEGAEAKPWYC and
- PUMACTANT a peptide characterized by an amino acid sequence comprising the hexamer TX 1 EX 2 X 3 E, wherein X 1 , X 2 and X 3 can be any natural or unnatural amino acid
- BLES a peptide characterized by an amino acid sequence comprising the hexamer TPEGAE and
- BLES a peptide comprising the amino acids QRETPEGAEAKPWY and BLES, a peptide comprising the amino acids CQRETPEGAEAKPWYC and BLES, a circularized peptide comprising the amino acids CQRETPEGAEAKPWYC and BLES, a peptide characterized by an amino acid sequence comprising the hexamer TX 1 EX 2 X 3 E, wherein X 1 , X 2 and X 3 can be any natural or unnatural amino acid, and SINAPULTIDE, a peptide characterized by an amino acid sequence comprising the hexamer TPEGAE and
- SINAPULTIDE a peptide comprising the amino acids QRETPEGAEAKPWY and SINAPULTIDE, a peptide comprising the amino acids CQRETPEGAEAKPWYC and SINAPULTIDE, and a circularized peptide comprising the amino acids CQRETPEGAEAKPWYC and
- LUSUPULTIDE a peptide comprising the amino acids QRETPEGAEAKPWY and LUSUPULTIDE, a peptide comprising the amino acids CQRETPEGAEAKPWYC and LUSUPULTIDE, or a circularized peptide comprising the amino acids CQRETPEGAEAKPWYC and
- More or less simultaneous administration of each therapeutic agent can be effected by, for example, intratracheal or intrabronchial administration to the subject in need thereof either as an instillation of the dissolved therapeutic agents, or as an aerosolised liquid or as a dry powder having a fixed ratio of each therapeutic agent.
- each therapeutic agent in succession can be ef ⁇ fected by any appropriate route, including, but not limited to, intratracheal or intrabronchial instillation or by inhalation.
- the therapeutic agents can be administered by the same route or by different routes.
- a pulmonary surfactant may be administered by intratracheal or intrabroncheal instilla ⁇ tion while the peptide may be administered by inhalation.
- the sequence in which the therapeutic agents are administered is not narrowly critical.
- pulmonary surfactant is the intratracheal or intrabron ⁇ chial route by instillation in liquid form or as aerosolised liquid or as dry powder. It is also preferred that the pulmonary surfactant is administered in form of an aerosolised liquid or a dry powder by inhalation. Dry powder formulations of pulmonary surfactants are preferably prepared by the spray drying process as described in WO 9726863.
- the most preferred route of administration of a peptide of present invention is the intratracheal or in ⁇ trabronchial route by instillation in liquid form or as aerosolised solution or as dry powder.
- a pulmonary surfactant preparation In case of intratracheal or intrabronchial administration of a pulmonary surfactant preparation, it has proven advantageous to administer suspensions or solutions of the preparations according to the in ⁇ vention which contain 10 to 100 mg of phospholipids per ml of suspension.
- the prepara ⁇ tions according to the invention are administered per application in such an amount that the amount of phospholipids is between 10 and 400 mg per kilogram of body weight.
- administration is car ⁇ ried out 1 to 3 times daily over a period of 1 to 7 days.
- a process is preferred in which the pulmonary surfactant suspension or solution employed contains 0.5 to 2.0 mg of rSP-C (FF/I) per ml of solvent. Particular mention may be made of a process in which the pulmonary surfactant solution employed contains 0.75 to 1.5 mg of rSP-C (FF/I) per ml of solvent.
- a peptide of present invention is administered at a dose between 1 microg/kg and 10 mg/kg, more preferably between 10 microg/kg and 5 mg/kg, most preferably between 0. 1 and 2 mg/kg.
- a peptide of present invention is adminis ⁇ tered at a dose of 1-10 mg/ml/kg body weight, particularly preferred at a dose of 1-2 mg/ml/kg body weight.
- the peptide of present invention is administered as an aerosol or by intratracheal nebu- lization
- the peptide is administered in a dose between 1-10 mg/ml/kg body weight, particularly pre ⁇ ferred at a dose of 1-2 mg/ml/kg body weight.
- the therapeutic agent(s) are formulated to give medicaments according to processes known per se and familiar to the person skilled in the art.
- the therapeutic agents are em ⁇ ployed as a medicament, preferably in combination with a salt, such as NaCI, preferably in 0,9 % NACI, the therapeutic agent content advantageously being between 0.1 and 95% by weight of total volume.
- each therapeutic agent is formulated to give a medicament according to processes known per se and familiar to the person skilled in the art.
- Each therapeutic agent is employed as a medica ⁇ ment, preferably in combination with a salt, such as NaCI, preferably in 0,9 % NACI, the therapeutic agent content advantageously being between 0.1 and 95% by weight of total volume.
- the therapeutic agent(s) of the present invention can be administered by a variety of methods known in the art, although for many therapeutic applications, the preferred route of administration is a fixed combination of a pulmonary surfactant and a peptide of present invention whereby the combination product is administered as a dry powder or as an aerosol by inhalation or by intratracheal or intrabron ⁇ chial instillation of a liquid.
- the pulmonary surfactant and the peptide of present invention it may be preferable to administer the pulmonary surfactant and the peptide of present invention as a free combination, whereby the pre ⁇ ferred route of administration is the intrabronchial instillation of single liquid formulations.
- the therapeutic agent(s) are dosed in an order of magnitude customary for the individual dose. It is more likely possible that the individual actions of the therapeutic agents are mutually positively influ ⁇ enced and reinforced and thus the respective doses on the combined administration of the therapeutic agent(s) may be reduced compared with the norm.
- compositions of present inventions comprising a combination of a pulmonary surfac ⁇ tant and a peptide have beneficial effects compared to pharmaceutical compositions comprising solely one of these active ingredients.
- an unexpected therapeutic benefit can be seen by administering a combination of a pulmonary surfactant and a peptide of pre ⁇ sent invention to a patient suffering from ARDS, IRDS, ALI or lung edema.
- a combination of a pulmonary surfactant and a peptide of present invention to superiorly ameliorate oxygenation in a patient in need thereof suffering from ARDS, IRDS, ALI or lung edema.
- This synergistic effect of the combination of a pulmonary surfactant and a peptide of present invention has been shown by in vivo studies as outlined in Example 5 and Fig. 1.
- the amount of the pulmonary surfactant may be significantly reduced when used in a combination with a pep ⁇ tide of present invention.
- pulmonary surfactant are comparatively costly and peptides of present inven ⁇ tion may be produced cost-saving by chemical synthesis, the cost of a treatment of a patient suffering from ARDS, IRDS, ALI or lung edema may be significantly reduced.
- the frequency of ungratefulness related to the application of a pul ⁇ monary surfactant, for example, by instillation may also be reduced compared to the use of a pulmonary surfactant alone.
- Patient packs have an advantage over traditional prescriptions, where a pharmacist divides a patient's supply of a pharma ⁇ ceutical from a bulk supply, in that the patient always has access to the package insert contained in the patient pack, normally missing in traditional prescriptions.
- the inclusion of a package insert has been shown to improve patient compliance with the physician's instructions and, therefore, lead gen ⁇ erally to more successful treatment.
- PaO 2 Arterial blood oxygenation
- TIP refers to a circularized peptide of present invention having the amino acid sequence of CGQRETPEGAEAKPWYC.
- Example 1 Fixed combination LUSUPULTIDE + TIP for intrabronchial instillation
- TIP 180 mg TIP is dissolved in 180 mL 0.9% sodium chloride.
- the 15.34 g of the surfactant composition are added to this solution and suspended.
- 1 ml/kg body weight of this suspension can be instilled intrabronchially guided by a bronchoscope.
- Example 2 Fixed combination LUSUPULTIDE + TIP for intratracheal nebulization
- Example 3 Free combination of BERACTANT for intratracheal instillation + TIP for aerosol administration
- BERACTANT for a single application in humans commercially available BERACTANT (Survanta®) is administered intratracheal ⁇ 100 mg/kg as a suspension in 0.9% sodium chloride containing 25 mg phospholipids per mL (consisting of 11.0 - 15.5 mg/mL disaturated phosphatidycholine, 0.5 - 1.75 mg/mL triglyc ⁇ erides, 1.4 - 3.5 mg/mL free fatty acids, and less than 1.0 mg/mL protein).
- This application is com ⁇ bined with one or several administrations of TIP. Therefore, the TIP 2 mg/mL is dissolved in 0.9% sodium chloride.
- Example 4 Free combination PORACTANT ALPHA for intratracheal instillation + TIP-peptide for intratracheal instillation
- PORACTANT ALPHA (Curosurf®) is ad ⁇ ministered intratracheally 100-200 mg/kg.
- Composition per mL of suspension phospholipid fraction from porcine lung 80 mg/mL, equivalent to about 74 mg/mL of total phospholipids and 0.9 mg/mL of low molecular weight hydrophobic proteins.
- This application is combined with one or several timed intratracheal administrations of 1 mg/kg TIP dissolved in 1 mg/ml 0.9% sodium chloride.
- Example 5 Influence of combined administration of a circularized peptide comprising the amino acid sequence CGQRETPEGAEAKPWYC and LUSUPULTIDE on arterial blood oxygena ⁇ tion after repeated saline lung lavage in rats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/658,727 US8236750B2 (en) | 2004-08-06 | 2005-07-27 | Composition comprising a pulmonary surfactant and a TNF-derived peptide |
AU2005268755A AU2005268755B2 (en) | 2004-08-06 | 2005-07-27 | Composition comprising a pulmonary surfactant and a TNF-derived peptide |
DE602005019416T DE602005019416D1 (en) | 2004-08-06 | 2005-07-27 | COMPOSITION OF A PULMONARY SURFACTANT AND A TNF-DERIVED PEPTIDE |
JP2007524331A JP5108515B2 (en) | 2004-08-06 | 2005-07-27 | Composition comprising pulmonary surfactant and TNF-derived peptide |
EP05767969A EP1781323B1 (en) | 2004-08-06 | 2005-07-27 | Composition comprising a pulmonary surfactant and a tnf-derived peptide |
CA2575513A CA2575513C (en) | 2004-08-06 | 2005-07-27 | Composition comprising a pulmonary surfactant and a tnf-derived peptide |
AT05767969T ATE457736T1 (en) | 2004-08-06 | 2005-07-27 | COMPOSITION OF A PULMONARY SURFACTANT AND A PEPTIDE DERIVED FROM TNF |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04103808.4 | 2004-08-06 | ||
EP04103808 | 2004-08-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006013183A1 true WO2006013183A1 (en) | 2006-02-09 |
Family
ID=34929426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/053672 WO2006013183A1 (en) | 2004-08-06 | 2005-07-27 | Composition comprising a pulmonary surfactant and a tnf-derived peptide |
Country Status (9)
Country | Link |
---|---|
US (1) | US8236750B2 (en) |
EP (1) | EP1781323B1 (en) |
JP (1) | JP5108515B2 (en) |
AT (1) | ATE457736T1 (en) |
AU (1) | AU2005268755B2 (en) |
CA (1) | CA2575513C (en) |
DE (1) | DE602005019416D1 (en) |
ES (1) | ES2339954T3 (en) |
WO (1) | WO2006013183A1 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008148545A1 (en) * | 2007-06-04 | 2008-12-11 | Rentschler Beteiligungs Gmbh | Novel peptides and their use for the treatment of edema |
JP2010503731A (en) * | 2006-09-19 | 2010-02-04 | ディスカバリー ラボラトリーズ,インコーポレイテッド | Lung surfactant formulation and method for promoting mucus clearance |
WO2010099556A1 (en) | 2009-03-05 | 2010-09-10 | Apeptico Forschung Und Entwicklung Gmbh | Method for preventing and treating hyperpermeability |
EP2679239A1 (en) * | 2012-06-28 | 2014-01-01 | Apeptico Forschung und Entwicklung GmbH | Pharmaceutical compound for treating the pulmonary form of altitude sickness caused by oxygen deprivation and reduced air pressure |
US8754049B2 (en) | 2010-01-14 | 2014-06-17 | Apeptico Forschung Und Entwicklung Gmbh | Organic compound for the regulation of vectorial ion channels |
WO2014173842A1 (en) * | 2013-04-23 | 2014-10-30 | Apeptico Forschung Und Entwicklung Gmbh | Lyophilisate containing a cyclic peptide of formula x1-gqretpegaeakpwy-x2 |
WO2014173843A1 (en) | 2013-04-23 | 2014-10-30 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition comprising a cyclic peptide of formula x1 -gqretpegaeakpwy-x2 and use for extracorporeal lung treatment |
WO2015132294A1 (en) * | 2014-03-04 | 2015-09-11 | Apeptico Forschung Und Entwicklung Gmbh | Attenuation of intrapulmonary inflammation |
WO2015140125A2 (en) | 2014-03-18 | 2015-09-24 | Apeptico Forschung Und Entwicklung Gmbh | Dry-powder peptide medicament |
US9359419B2 (en) | 2010-06-21 | 2016-06-07 | Apeptico Forschung Und Entwicklung Gmbh | Treatment of vascular complications of diabetes |
WO2016174269A1 (en) * | 2015-04-30 | 2016-11-03 | University Of Bremen | A novel skin medical and cosmetic care product |
WO2021223894A1 (en) | 2020-05-08 | 2021-11-11 | Apeptico Forschung Und Entwicklung Gmbh | Peptide for prevention or treatment of covid-19 |
US12004506B2 (en) | 2013-04-23 | 2024-06-11 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition comprising a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 and use for extracorporeal lung treatment |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT510585B1 (en) | 2010-11-18 | 2012-05-15 | Apeptico Forschung & Entwicklung Gmbh | COMPOSITION COMPRISING A PEPTIDE AND AN INHIBITOR OF VIRAL NEURAMINIDASE |
CN106821982A (en) * | 2017-01-12 | 2017-06-13 | 东南大学 | A kind of sinapultide microbubble agents and preparation method thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4944941A (en) * | 1987-08-07 | 1990-07-31 | Genentech, Inc. | Methods and compositions for the treatment of lung conditions |
WO2000009149A1 (en) * | 1998-08-14 | 2000-02-24 | Innogenetics N.V. | Tnf-derived peptides for use in treating oedema |
DE19851617A1 (en) * | 1998-11-10 | 2000-05-11 | Byk Gulden Lomberg Chem Fab | Treatment of infant and adult respiratory distress syndrome comprises bronchoalveolar lavage with a dilute lung surfactant solution followed by administration of a lung surfactant |
US20030091509A1 (en) * | 2000-02-11 | 2003-05-15 | Haefner Dietrich | Novel use of pulmonary surfactant for the prophylaxis and treatment of chronic pulmonary diseases |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3229179C2 (en) | 1982-08-05 | 1986-04-17 | A. Nattermann & Cie GmbH, 5000 Köln | Pulmonary surfactant |
DE3369644D1 (en) | 1982-11-22 | 1987-03-12 | Teijin Ltd | Artificial lung surfactant and remedy for respiratory distress syndrome containing it as active principle |
JPS59164724A (en) | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | Surfactant and remedy for respiratory distress syndrome containing the same |
CS938384A1 (en) | 1983-12-08 | 1990-08-14 | Lachmann Burkhardt | Pharmaceutical agent for breathlesness therapy and method of its production |
US4659805A (en) | 1984-12-11 | 1987-04-21 | California Biotechnology, Inc. | Recombinant alveolar surfactant protein |
US5104853A (en) | 1984-12-11 | 1992-04-14 | California Biotechnology Inc. | Alveolar surfactant proteins having cys to ser mutations |
US4933280A (en) | 1984-12-11 | 1990-06-12 | California Biotechnology Inc. | Recombinant DNA sequence encoding Alveolar Surfactant Protein |
EP0273916A4 (en) | 1986-05-06 | 1989-11-30 | Childrens Hosp Medical Center | Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof. |
EP0290516A4 (en) | 1986-10-24 | 1989-11-14 | Jeffrey A Whitsett | Pulmonary hydrophobic surfactant-associated proteins. |
IT1203873B (en) | 1987-04-08 | 1989-02-23 | Chiesi Farma Spa | PHARMACEUTICAL COMPOSITIONS THAT THE NATURAL PULMONARY SURFACTANT CONTAIN. PREPARATION METHOD E |
AU625394B2 (en) | 1987-11-04 | 1992-07-09 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Alveolar surfactant proteins |
US5260273A (en) | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
US5164369A (en) | 1988-01-06 | 1992-11-17 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
AR245141A1 (en) | 1988-07-01 | 1993-12-30 | Merrell Dow Pharma | Procedure for solid-phase sequential or block synthesis, for preparing helicoidal structure polypeptides. |
SE8803713D0 (en) | 1988-10-18 | 1988-10-18 | Kabigen Ab | BIOLOGICALLY ACTIVE LIPOPROTEIN AND ITS USE |
DE4418936A1 (en) | 1994-05-31 | 1996-02-08 | Byk Gulden Lomberg Chem Fab | Polypeptide |
KR100449789B1 (en) | 1996-01-24 | 2005-02-03 | 알타나 파마 아게 | Manufacturing Method of Powdered Lung Surfactant |
WO1997035882A1 (en) | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
ES2271990T3 (en) * | 1997-02-17 | 2007-04-16 | Altana Pharma Ag | COMPOSITIONS FOR THE TREATMENT OF ARDS OR IRDS CONTAINING 3- (CICLOPROPILMETOXI) -N- (3,5-DICLORO-4-PIRIDINIL) -4- (DIFLUOROMETOXI) BENZAMINE AND A PULMONARY TENSIUM. |
ES2253003T3 (en) | 1998-11-10 | 2006-05-16 | Altana Pharma Ag | TREATMENT EQUIPMENT CONTAINING COMPOSITIONS BASED ON PULMONARY TENSIOACTIVE AGENTS. |
JP2003530356A (en) | 2000-04-12 | 2003-10-14 | アルタナ ファルマ アクチエンゲゼルシャフト | Novel use of pulmonary surfactant for prevention or early treatment of acute lung disease |
SE0102055D0 (en) | 2001-06-08 | 2001-06-08 | Astrazeneca Ab | New Compounds |
EP1435994B1 (en) | 2001-10-11 | 2010-05-19 | Nycomed GmbH | Novel use of pulmonary surfactant |
-
2005
- 2005-07-27 AU AU2005268755A patent/AU2005268755B2/en not_active Ceased
- 2005-07-27 CA CA2575513A patent/CA2575513C/en not_active Expired - Fee Related
- 2005-07-27 DE DE602005019416T patent/DE602005019416D1/en active Active
- 2005-07-27 ES ES05767969T patent/ES2339954T3/en active Active
- 2005-07-27 EP EP05767969A patent/EP1781323B1/en not_active Not-in-force
- 2005-07-27 AT AT05767969T patent/ATE457736T1/en not_active IP Right Cessation
- 2005-07-27 JP JP2007524331A patent/JP5108515B2/en not_active Expired - Fee Related
- 2005-07-27 US US11/658,727 patent/US8236750B2/en not_active Expired - Fee Related
- 2005-07-27 WO PCT/EP2005/053672 patent/WO2006013183A1/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4944941A (en) * | 1987-08-07 | 1990-07-31 | Genentech, Inc. | Methods and compositions for the treatment of lung conditions |
WO2000009149A1 (en) * | 1998-08-14 | 2000-02-24 | Innogenetics N.V. | Tnf-derived peptides for use in treating oedema |
US20030185791A1 (en) * | 1998-08-14 | 2003-10-02 | Rudolf Lucas | TNF-derived peptides for use in treating oedema |
DE19851617A1 (en) * | 1998-11-10 | 2000-05-11 | Byk Gulden Lomberg Chem Fab | Treatment of infant and adult respiratory distress syndrome comprises bronchoalveolar lavage with a dilute lung surfactant solution followed by administration of a lung surfactant |
US20030091509A1 (en) * | 2000-02-11 | 2003-05-15 | Haefner Dietrich | Novel use of pulmonary surfactant for the prophylaxis and treatment of chronic pulmonary diseases |
Non-Patent Citations (1)
Title |
---|
FRERKING I ET AL: "Pulmonary surfactant: functions, abnormalities and therapeutic options.", INTENSIVE CARE MEDICINE. NOV 2001, vol. 27, no. 11, November 2001 (2001-11-01), pages 1699 - 1717, XP002312317, ISSN: 0342-4642 * |
Cited By (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010503731A (en) * | 2006-09-19 | 2010-02-04 | ディスカバリー ラボラトリーズ,インコーポレイテッド | Lung surfactant formulation and method for promoting mucus clearance |
EP2009023A1 (en) * | 2007-06-04 | 2008-12-31 | Rentschler Beteiligungs GmbH | Novel peptides and their use for the treatment of edema |
WO2008148545A1 (en) * | 2007-06-04 | 2008-12-11 | Rentschler Beteiligungs Gmbh | Novel peptides and their use for the treatment of edema |
WO2010099556A1 (en) | 2009-03-05 | 2010-09-10 | Apeptico Forschung Und Entwicklung Gmbh | Method for preventing and treating hyperpermeability |
EP2403519A1 (en) * | 2009-03-05 | 2012-01-11 | Apeptico Forschung Und Entwicklung Gmbh | Method for preventing and treating hyperpermeability |
US11639368B2 (en) | 2009-03-05 | 2023-05-02 | Apeptico Forschung Und Entwicklung Gmbh | Method for preventing and treating hyperpermeability |
AU2010220800B2 (en) * | 2009-03-05 | 2014-03-27 | Apeptico Forschung Und Entwicklung Gmbh | Method for preventing and treating hyperpermeability |
EP2403519B1 (en) * | 2009-03-05 | 2017-11-15 | APEPTICO Forschung und Entwicklung GmbH | Method for preventing and treating hyperpermeability |
US8754049B2 (en) | 2010-01-14 | 2014-06-17 | Apeptico Forschung Und Entwicklung Gmbh | Organic compound for the regulation of vectorial ion channels |
US9359419B2 (en) | 2010-06-21 | 2016-06-07 | Apeptico Forschung Und Entwicklung Gmbh | Treatment of vascular complications of diabetes |
EA030384B1 (en) * | 2012-06-28 | 2018-07-31 | Апептико Форшунг Унд Энтвиклунг Гмбх | Therapy of the pulmonary form of altitude sickness |
AU2013283563B2 (en) * | 2012-06-28 | 2017-06-08 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition for treatment of the pulmonary form of altitude sickness caused by lack of oxygen and reduced air pressure |
EP2679239A1 (en) * | 2012-06-28 | 2014-01-01 | Apeptico Forschung und Entwicklung GmbH | Pharmaceutical compound for treating the pulmonary form of altitude sickness caused by oxygen deprivation and reduced air pressure |
WO2014001177A1 (en) * | 2012-06-28 | 2014-01-03 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition for treatment of the pulmonary form of altitude sickness caused by lack of oxygen and reduced air pressure |
US9802985B2 (en) | 2012-06-28 | 2017-10-31 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition for treatment of the pulmonary form of altitude sickness caused by lack of oxygen and reduced air pressure |
US10711041B2 (en) | 2013-04-23 | 2020-07-14 | Apeptico Forschung Und Entwicklung Gmbh | Lyophilisate containing a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 |
CN105188735A (en) * | 2013-04-23 | 2015-12-23 | 阿佩普蒂科研究和开发有限责任公司 | Pharmaceutical composition comprising a cyclic peptide of formula x1 -gqretpegaeakpwy-x2 and use for extracorporeal lung treatment |
WO2014173843A1 (en) | 2013-04-23 | 2014-10-30 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition comprising a cyclic peptide of formula x1 -gqretpegaeakpwy-x2 and use for extracorporeal lung treatment |
US12004506B2 (en) | 2013-04-23 | 2024-06-11 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition comprising a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 and use for extracorporeal lung treatment |
EA038363B1 (en) * | 2013-04-23 | 2021-08-16 | Апептико Форшунг Унд Энтвиклунг Гмбх | Aqueous aerosol for inhalation free of additives and/or stabilizers, comprising a cyclic peptide of formula x1-gqretpegaeakpwy-x2 |
KR20150144757A (en) * | 2013-04-23 | 2015-12-28 | 아펩티코 포어슝 운트 엔트빅크룽 게엠베하 | Pharmaceutical composition comprising a cyclic peptide of formula x_1-gqretpegaeakpwy-x_2 and use for extracorporeal lung treatment |
CN105188734A (en) * | 2013-04-23 | 2015-12-23 | 阿佩普蒂科研究和开发有限责任公司 | Lyophilisate containing a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 |
WO2014173842A1 (en) * | 2013-04-23 | 2014-10-30 | Apeptico Forschung Und Entwicklung Gmbh | Lyophilisate containing a cyclic peptide of formula x1-gqretpegaeakpwy-x2 |
KR102217476B1 (en) | 2013-04-23 | 2021-02-19 | 아펩티코 포어슝 운트 엔트빅크룽 게엠베하 | Lyophilisate containing a cyclic peptide of formula x₁-gqretpegaeakpwy-x₂ |
KR20160002813A (en) * | 2013-04-23 | 2016-01-08 | 아펩티코 포어슝 운트 엔트빅크룽 게엠베하 | Lyophilisate containing a cyclic peptide of formula x_1 -gqretpegaeakpwy-x_2 |
CN105188734B (en) * | 2013-04-23 | 2019-03-01 | 阿佩普蒂科研究和开发有限责任公司 | The lyophilized products of cyclic peptide containing Formula X 1-GQRETPEGAEAKPWY-X2 |
EA032975B1 (en) * | 2013-04-23 | 2019-08-30 | Апептико Форшунг Унд Энтвиклунг Гмбх | Pharmaceutical composition comprising a cyclic peptide of formula x-gqretpegaeakpwy-xand use for extracorporeal lung treatment |
KR102113501B1 (en) * | 2013-04-23 | 2020-05-22 | 아펩티코 포어슝 운트 엔트빅크룽 게엠베하 | Pharmaceutical composition comprising a cyclic peptide of formula x₁-gqretpegaeakpwy-x₂ and use for extracorporeal lung treatment |
CN106061495B (en) * | 2014-03-04 | 2020-02-07 | 阿佩普蒂科研究和开发有限责任公司 | Attenuation of inflammation in the lung |
WO2015132294A1 (en) * | 2014-03-04 | 2015-09-11 | Apeptico Forschung Und Entwicklung Gmbh | Attenuation of intrapulmonary inflammation |
CN106061495A (en) * | 2014-03-04 | 2016-10-26 | 阿佩普蒂科研究和开发有限责任公司 | Attenuation of intrapulmonary inflammation |
WO2015140125A2 (en) | 2014-03-18 | 2015-09-24 | Apeptico Forschung Und Entwicklung Gmbh | Dry-powder peptide medicament |
CN107979996A (en) * | 2015-04-30 | 2018-05-01 | 不莱梅大学 | New transdermal medical and aesthetic care products |
WO2016174269A1 (en) * | 2015-04-30 | 2016-11-03 | University Of Bremen | A novel skin medical and cosmetic care product |
WO2021223894A1 (en) | 2020-05-08 | 2021-11-11 | Apeptico Forschung Und Entwicklung Gmbh | Peptide for prevention or treatment of covid-19 |
Also Published As
Publication number | Publication date |
---|---|
CA2575513C (en) | 2014-09-16 |
ATE457736T1 (en) | 2010-03-15 |
EP1781323A1 (en) | 2007-05-09 |
JP2008509107A (en) | 2008-03-27 |
US8236750B2 (en) | 2012-08-07 |
EP1781323B1 (en) | 2010-02-17 |
US20070299003A1 (en) | 2007-12-27 |
DE602005019416D1 (en) | 2010-04-01 |
AU2005268755B2 (en) | 2011-04-07 |
JP5108515B2 (en) | 2012-12-26 |
AU2005268755A1 (en) | 2006-02-09 |
ES2339954T3 (en) | 2010-05-27 |
CA2575513A1 (en) | 2006-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2005268755B2 (en) | Composition comprising a pulmonary surfactant and a TNF-derived peptide | |
JP5405307B2 (en) | Reconstructed surfactant with improved properties | |
AU734122B2 (en) | Compositions for the treatment of ARDS or IRDS containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4- (difluoromethoxy)benzamide and lung surfactant | |
EP2922868B1 (en) | Reconstituted pulmonary surfactants | |
EP2009023A1 (en) | Novel peptides and their use for the treatment of edema | |
US7053176B1 (en) | Combination of C1-INH and lung surfactant for the treatment of respiratory disorders | |
EP1131055B1 (en) | Treatment set containing lungsurfactant compositions | |
US20030091509A1 (en) | Novel use of pulmonary surfactant for the prophylaxis and treatment of chronic pulmonary diseases | |
US6858223B2 (en) | Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS) | |
CA2405811C (en) | Novel use of pulmonary surfactant for the prophylaxis or early treatment of acute pulmonary diseases | |
CA2372558A1 (en) | Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c) | |
EP1098645B1 (en) | Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ards) and infant respiratory distress syndrome (irds) | |
US20040254112A1 (en) | Use of pulmonary surfactant for the early treatment of acute pulmonary diseases | |
JP2001089391A (en) | Pharmaceutical composition for treating irds and ali and use thereof and product having the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
WWE | Wipo information: entry into national phase |
Ref document number: 11658727 Country of ref document: US Ref document number: 2575513 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007524331 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005767969 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005268755 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2005268755 Country of ref document: AU Date of ref document: 20050727 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2005268755 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 2005767969 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 11658727 Country of ref document: US |